FAM227A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.01910019
2cilium or flagellum-dependent cell motility (GO:0001539)6.86096584
3behavioral response to nicotine (GO:0035095)5.35303803
4axoneme assembly (GO:0035082)5.26767038
5DNA deamination (GO:0045006)5.20485147
6ribosomal small subunit assembly (GO:0000028)4.89465591
7motile cilium assembly (GO:0044458)4.70206586
8regulation of cilium movement (GO:0003352)4.57802812
9lymphoid progenitor cell differentiation (GO:0002320)4.51522880
10platelet dense granule organization (GO:0060155)4.31239590
11intraciliary transport (GO:0042073)4.24047008
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20386035
13cilium organization (GO:0044782)4.08835657
14viral transcription (GO:0019083)4.04611464
15respiratory chain complex IV assembly (GO:0008535)4.03166098
16cilium assembly (GO:0042384)3.99871477
17facial nerve structural organization (GO:0021612)3.99277218
18ribosomal small subunit biogenesis (GO:0042274)3.98189881
19translational termination (GO:0006415)3.82477557
20cilium morphogenesis (GO:0060271)3.77579980
21protein localization to cilium (GO:0061512)3.72752071
22nonmotile primary cilium assembly (GO:0035058)3.68449782
23mannosylation (GO:0097502)3.64736598
24response to interferon-beta (GO:0035456)3.61060196
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60555606
26cotranslational protein targeting to membrane (GO:0006613)3.55875160
27protein targeting to ER (GO:0045047)3.50464913
28cytochrome complex assembly (GO:0017004)3.46463605
29indole-containing compound catabolic process (GO:0042436)3.44903275
30indolalkylamine catabolic process (GO:0046218)3.44903275
31tryptophan catabolic process (GO:0006569)3.44903275
32protein polyglutamylation (GO:0018095)3.44110174
33polyketide metabolic process (GO:0030638)3.43979947
34doxorubicin metabolic process (GO:0044598)3.43979947
35daunorubicin metabolic process (GO:0044597)3.43979947
36neural tube formation (GO:0001841)3.42330938
37negative regulation of myotube differentiation (GO:0010832)3.38983532
38response to pheromone (GO:0019236)3.36257556
39protein localization to endoplasmic reticulum (GO:0070972)3.34787349
40piRNA metabolic process (GO:0034587)3.31119375
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30148269
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28763335
43indolalkylamine metabolic process (GO:0006586)3.28243732
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28132719
45detection of light stimulus involved in visual perception (GO:0050908)3.27829812
46detection of light stimulus involved in sensory perception (GO:0050962)3.27829812
47GPI anchor biosynthetic process (GO:0006506)3.26805713
48maturation of SSU-rRNA (GO:0030490)3.22367311
49regulation of microtubule-based movement (GO:0060632)3.22200451
50kynurenine metabolic process (GO:0070189)3.20776340
51GTP biosynthetic process (GO:0006183)3.20100992
52regulation of pigment cell differentiation (GO:0050932)3.19108785
53photoreceptor cell maintenance (GO:0045494)3.18158470
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16714146
55transmission of nerve impulse (GO:0019226)3.16683319
56proteasome assembly (GO:0043248)3.16054823
57cellular component assembly involved in morphogenesis (GO:0010927)3.14386056
58cellular ketone body metabolic process (GO:0046950)3.12606434
59cornea development in camera-type eye (GO:0061303)3.10322673
60cellular response to interferon-beta (GO:0035458)3.08804634
61definitive hemopoiesis (GO:0060216)3.08416740
62C-terminal protein lipidation (GO:0006501)3.08273546
63left/right pattern formation (GO:0060972)3.07578498
64postsynaptic membrane organization (GO:0001941)3.06517480
65pyrimidine nucleobase catabolic process (GO:0006208)3.05729299
66left/right axis specification (GO:0070986)3.05377136
67mature B cell differentiation involved in immune response (GO:0002313)3.04486038
68translational elongation (GO:0006414)3.01874216
69cranial nerve morphogenesis (GO:0021602)2.99500578
70L-fucose catabolic process (GO:0042355)2.99331333
71fucose catabolic process (GO:0019317)2.99331333
72L-fucose metabolic process (GO:0042354)2.99331333
73microtubule bundle formation (GO:0001578)2.98950737
74cell proliferation in forebrain (GO:0021846)2.95231318
75viral life cycle (GO:0019058)2.94419369
76cranial nerve structural organization (GO:0021604)2.93908900
77tryptophan metabolic process (GO:0006568)2.93041187
78defense response to protozoan (GO:0042832)2.92726905
79DNA methylation involved in gamete generation (GO:0043046)2.92196964
80tRNA methylation (GO:0030488)2.91458217
81regulation of collateral sprouting (GO:0048670)2.90812906
82telomere maintenance via semi-conservative replication (GO:0032201)2.90705723
83smoothened signaling pathway (GO:0007224)2.88529665
84retinal cone cell development (GO:0046549)2.88408349
85mature B cell differentiation (GO:0002335)2.86034296
86regulation of T cell mediated cytotoxicity (GO:0001914)2.84509527
87sperm motility (GO:0030317)2.84409814
88centriole replication (GO:0007099)2.83577360
89presynaptic membrane assembly (GO:0097105)2.83554632
90axonemal dynein complex assembly (GO:0070286)2.82434613
91negative regulation of transcription by competitive promoter binding (GO:0010944)2.81341572
92ketone body metabolic process (GO:1902224)2.81135515
93neuronal action potential (GO:0019228)2.80813267
94spinal cord motor neuron differentiation (GO:0021522)2.80531015
95gamma-aminobutyric acid transport (GO:0015812)2.80410840
96preassembly of GPI anchor in ER membrane (GO:0016254)2.77949733
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.77860953
98termination of RNA polymerase III transcription (GO:0006386)2.77860953
99somite development (GO:0061053)2.75727228
100cellular protein complex disassembly (GO:0043624)2.75666444
101regulation of action potential (GO:0098900)2.73683112
102CTP biosynthetic process (GO:0006241)2.72595932
103CTP metabolic process (GO:0046036)2.72595932
104negative regulation of telomere maintenance (GO:0032205)2.71709283
105protein complex biogenesis (GO:0070271)2.71709085
106GPI anchor metabolic process (GO:0006505)2.69711965
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69614363
108limb bud formation (GO:0060174)2.69432320
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68874944
110developmental pigmentation (GO:0048066)2.68120521
111retinal ganglion cell axon guidance (GO:0031290)2.67779228
112ventricular system development (GO:0021591)2.67245193
113behavioral response to ethanol (GO:0048149)2.65275475
114C-terminal protein amino acid modification (GO:0018410)2.63958981
115appendage development (GO:0048736)2.63213895
116limb development (GO:0060173)2.63213895
117fucosylation (GO:0036065)2.63105751
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62209302
119mitochondrial respiratory chain complex I assembly (GO:0032981)2.62209302
120NADH dehydrogenase complex assembly (GO:0010257)2.62209302
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.61702231
122ribosomal large subunit biogenesis (GO:0042273)2.59678504
123endosome to melanosome transport (GO:0035646)2.59537862
124endosome to pigment granule transport (GO:0043485)2.59537862
125determination of left/right symmetry (GO:0007368)2.59513817
126cellular biogenic amine catabolic process (GO:0042402)2.59191225
127amine catabolic process (GO:0009310)2.59191225
128rRNA catabolic process (GO:0016075)2.58842269
129nucleobase catabolic process (GO:0046113)2.58755361
130response to protozoan (GO:0001562)2.58617428
131photoreceptor cell development (GO:0042461)2.56861844
132protein K11-linked deubiquitination (GO:0035871)2.55557792
133neuron fate determination (GO:0048664)2.54891136
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.54621481
135secretory granule organization (GO:0033363)2.52653725
136synaptic transmission, cholinergic (GO:0007271)2.52324677
137reciprocal DNA recombination (GO:0035825)2.51545612
138reciprocal meiotic recombination (GO:0007131)2.51545612
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51533486
140head development (GO:0060322)2.51030542
141inner ear receptor stereocilium organization (GO:0060122)2.50373502
142cell projection assembly (GO:0030031)2.50254428
143mast cell activation (GO:0045576)2.49254794
144cell differentiation in spinal cord (GO:0021515)2.49024299
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49001845
146pseudouridine synthesis (GO:0001522)2.48779380
147nephron epithelium morphogenesis (GO:0072088)2.48633528
148nephron tubule morphogenesis (GO:0072078)2.48633528
149positive regulation of gastrulation (GO:2000543)2.48477208
150positive regulation of granulocyte differentiation (GO:0030854)2.48402622
151amino sugar catabolic process (GO:0046348)2.47420814
152centriole assembly (GO:0098534)2.47192007
153regulation of regulatory T cell differentiation (GO:0045589)2.46777268
154positive regulation of protein sumoylation (GO:0033235)2.46711780
155negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46157262
156telomere maintenance via recombination (GO:0000722)2.46141063
157reflex (GO:0060004)2.45795833
158tRNA modification (GO:0006400)2.45617829
159UTP biosynthetic process (GO:0006228)2.45596960
160indole-containing compound metabolic process (GO:0042430)2.45504882
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45352086
162sulfation (GO:0051923)2.44228286
163antigen processing and presentation via MHC class Ib (GO:0002475)2.43748642
164pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.43679346
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43346559
166male meiosis I (GO:0007141)2.43251966
167negative regulation of mast cell activation (GO:0033004)2.42965899
168determination of bilateral symmetry (GO:0009855)2.42914645
169immunoglobulin mediated immune response (GO:0016064)2.41937562
170mitochondrial respiratory chain complex assembly (GO:0033108)2.39740531
171negative regulation of translation, ncRNA-mediated (GO:0040033)2.39361378
172regulation of translation, ncRNA-mediated (GO:0045974)2.39361378
173negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39361378
174negative regulation of T-helper cell differentiation (GO:0045623)2.39324322
175negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39324322
176water-soluble vitamin biosynthetic process (GO:0042364)2.39248546
177nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37489190
178presynaptic membrane organization (GO:0097090)2.36855117
179epithelial cilium movement (GO:0003351)2.36576945
180protein complex disassembly (GO:0043241)2.36000735
181cilium movement (GO:0003341)2.35774000
182response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.35529829
183iron-sulfur cluster assembly (GO:0016226)2.34431299
184metallo-sulfur cluster assembly (GO:0031163)2.34431299
185response to interferon-alpha (GO:0035455)2.33160818
186guanosine-containing compound biosynthetic process (GO:1901070)2.33084159
187dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.32600019
188translational initiation (GO:0006413)2.32384817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.77386164
2EZH2_22144423_ChIP-Seq_EOC_Human4.42795151
3ZNF274_21170338_ChIP-Seq_K562_Hela3.60263483
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17702194
5VDR_22108803_ChIP-Seq_LS180_Human3.15007234
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96763504
7SCL_19346495_ChIP-Seq_HPC-7_Human2.78666996
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.73595947
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.54586907
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.54538677
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.52169963
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42406104
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40329051
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38204732
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36175948
16GBX2_23144817_ChIP-Seq_PC3_Human2.32351287
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.31355372
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28445189
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21382348
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17381187
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15164340
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.13148783
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06698382
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00793858
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.96075645
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94764794
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93776987
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91862093
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91739922
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90898963
31IRF1_19129219_ChIP-ChIP_H3396_Human1.89324301
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86545138
33ER_23166858_ChIP-Seq_MCF-7_Human1.79960332
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.79093072
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77961594
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76905746
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76153641
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75718069
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71453873
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.68019197
41SMAD4_21799915_ChIP-Seq_A2780_Human1.66939011
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65434276
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65381283
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65250717
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64862797
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.64457417
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64151328
48REST_21632747_ChIP-Seq_MESCs_Mouse1.64111607
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60571693
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60571693
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60349772
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.59837341
53STAT3_23295773_ChIP-Seq_U87_Human1.59116435
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56001855
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.55863904
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55297039
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55177180
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54337429
59TAF15_26573619_Chip-Seq_HEK293_Human1.53954754
60AR_25329375_ChIP-Seq_VCAP_Human1.53679514
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53219501
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53021274
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52626399
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.52551830
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50177881
66CBP_20019798_ChIP-Seq_JUKART_Human1.50177881
67BCAT_22108803_ChIP-Seq_LS180_Human1.49526176
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48117854
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47214861
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46885108
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.45959761
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45813717
73TCF4_23295773_ChIP-Seq_U87_Human1.45641107
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43160283
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41390930
76DROSHA_22980978_ChIP-Seq_HELA_Human1.40768558
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39797909
78VDR_23849224_ChIP-Seq_CD4+_Human1.38361862
79SPI1_23547873_ChIP-Seq_NB4_Human1.38343671
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37015657
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35790791
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35634714
83TP53_22573176_ChIP-Seq_HFKS_Human1.34766441
84RUNX2_22187159_ChIP-Seq_PCA_Human1.32057934
85TCF4_22108803_ChIP-Seq_LS180_Human1.31147513
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30336326
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.29022739
88AR_21572438_ChIP-Seq_LNCaP_Human1.26947601
89RNF2_27304074_Chip-Seq_NSC_Mouse1.25911095
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.23533117
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.23334321
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.23275623
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23275623
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22906406
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22376994
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21696022
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.21338233
98FOXP3_21729870_ChIP-Seq_TREG_Human1.20528450
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.20125525
100P53_22387025_ChIP-Seq_ESCs_Mouse1.19549747
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19508462
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19444033
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.19125812
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18835188
105SOX2_19829295_ChIP-Seq_ESCs_Human1.18773692
106NANOG_19829295_ChIP-Seq_ESCs_Human1.18773692
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18692905
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17973812
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17729552
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17692482
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.16095947
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15074499
113ETS1_20019798_ChIP-Seq_JURKAT_Human1.14581156
114FUS_26573619_Chip-Seq_HEK293_Human1.14452904
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.13837871
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.12686654
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12501139
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.11242870
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.11170448
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10674659
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10437466
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10300646
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.09867286
124NCOR_22424771_ChIP-Seq_293T_Human1.09346570
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08831335
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.08386022
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06746895
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.06109349
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06059151
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05580879
131P300_18555785_Chip-Seq_ESCs_Mouse1.05564392
132TP53_16413492_ChIP-PET_HCT116_Human1.05412001
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04775656
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03320055
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.02999410
136JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02992941
137AR_20517297_ChIP-Seq_VCAP_Human1.02345209
138HOXB7_26014856_ChIP-Seq_BT474_Human1.01266894
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00848774
140MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00401806
141SOX2_21211035_ChIP-Seq_LN229_Gbm1.00341874
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.99357731
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99267355
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99214284
145MYC_18940864_ChIP-ChIP_HL60_Human0.98953216
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.97630268
147SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97512284
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97110392
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.96718666
150ZFX_18555785_Chip-Seq_ESCs_Mouse0.96594855
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96437379
152PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95406377
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95387729
154GATA1_22025678_ChIP-Seq_K562_Human0.94772177
155ELK1_19687146_ChIP-ChIP_HELA_Human0.94456584
156P300_19829295_ChIP-Seq_ESCs_Human0.93914520
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.92972895
158CTCF_18555785_Chip-Seq_ESCs_Mouse0.92842241
159SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92710645
160EWS_26573619_Chip-Seq_HEK293_Human0.92571764
161TP63_19390658_ChIP-ChIP_HaCaT_Human0.91884900
162MYC_18555785_ChIP-Seq_MESCs_Mouse0.91877481
163PU1_27457419_Chip-Seq_LIVER_Mouse0.91381212
164LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91281796
165KLF4_18555785_Chip-Seq_ESCs_Mouse0.91227443
166FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91153879
167CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90937115
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89964727
169CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87984081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.82724679
2MP0006292_abnormal_olfactory_placode3.80299958
3MP0001188_hyperpigmentation3.64086786
4MP0005174_abnormal_tail_pigmentation3.54092552
5MP0002653_abnormal_ependyma_morphology3.47540674
6MP0003136_yellow_coat_color3.39498325
7MP0005409_darkened_coat_color3.17892083
8MP0000015_abnormal_ear_pigmentation2.97368251
9MP0005075_abnormal_melanosome_morpholog2.82321291
10MP0004381_abnormal_hair_follicle2.67160560
11MP0003880_abnormal_central_pattern2.66358485
12MP0008877_abnormal_DNA_methylation2.62613102
13MP0001986_abnormal_taste_sensitivity2.57072596
14MP0001835_abnormal_antigen_presentation2.40533796
15MP0003724_increased_susceptibility_to2.29284932
16MP0005671_abnormal_response_to2.24418407
17MP0002095_abnormal_skin_pigmentation2.20714469
18MP0008875_abnormal_xenobiotic_pharmacok2.19284364
19MP0009785_altered_susceptibility_to2.17317704
20MP0003195_calcinosis2.16271884
21MP0004133_heterotaxia2.05631270
22MP0009046_muscle_twitch2.01442231
23MP0002102_abnormal_ear_morphology1.99204857
24MP0000372_irregular_coat_pigmentation1.98995397
25MP0001485_abnormal_pinna_reflex1.96249998
26MP0003787_abnormal_imprinting1.91765197
27MP0000685_abnormal_immune_system1.86706380
28MP0006072_abnormal_retinal_apoptosis1.80892970
29MP0009745_abnormal_behavioral_response1.78956082
30MP0004043_abnormal_pH_regulation1.78778471
31MP0002148_abnormal_hypersensitivity_rea1.77319652
32MP0002638_abnormal_pupillary_reflex1.70395283
33MP0000778_abnormal_nervous_system1.65189147
34MP0005025_abnormal_response_to1.64431163
35MP0004147_increased_porphyrin_level1.63524620
36MP0004885_abnormal_endolymph1.62539851
37MP0000569_abnormal_digit_pigmentation1.62232076
38MP0002396_abnormal_hematopoietic_system1.57684602
39MP0005377_hearing/vestibular/ear_phenot1.57491318
40MP0003878_abnormal_ear_physiology1.57491318
41MP0008058_abnormal_DNA_repair1.55369975
42MP0000427_abnormal_hair_cycle1.52484039
43MP0002928_abnormal_bile_duct1.52150882
44MP0003763_abnormal_thymus_physiology1.51151523
45MP0002735_abnormal_chemical_nociception1.50864388
46MP0005000_abnormal_immune_tolerance1.44222916
47MP0002572_abnormal_emotion/affect_behav1.43315665
48MP0003646_muscle_fatigue1.42007055
49MP0005423_abnormal_somatic_nervous1.41157245
50MP0000681_abnormal_thyroid_gland1.40600360
51MP0000566_synostosis1.38627826
52MP0000383_abnormal_hair_follicle1.37177901
53MP0002876_abnormal_thyroid_physiology1.37159831
54MP0002723_abnormal_immune_serum1.36755584
55MP0008872_abnormal_physiological_respon1.36741275
56MP0002557_abnormal_social/conspecific_i1.36638185
57MP0003122_maternal_imprinting1.34924293
58MP0002132_abnormal_respiratory_system1.33478612
59MP0002837_dystrophic_cardiac_calcinosis1.31421401
60MP0008995_early_reproductive_senescence1.31413634
61MP0003121_genomic_imprinting1.30871168
62MP0002420_abnormal_adaptive_immunity1.30631100
63MP0005394_taste/olfaction_phenotype1.30107053
64MP0005499_abnormal_olfactory_system1.30107053
65MP0001529_abnormal_vocalization1.29405312
66MP0004742_abnormal_vestibular_system1.28999464
67MP0001819_abnormal_immune_cell1.28573167
68MP0002419_abnormal_innate_immunity1.28455782
69MP0002234_abnormal_pharynx_morphology1.28432655
70MP0001800_abnormal_humoral_immune1.26643217
71MP0002734_abnormal_mechanical_nocicepti1.26564421
72MP0002452_abnormal_antigen_presenting1.26483132
73MP0002064_seizures1.26270202
74MP0004142_abnormal_muscle_tone1.25465825
75MP0003436_decreased_susceptibility_to1.24228679
76MP0001501_abnormal_sleep_pattern1.24126974
77MP0005195_abnormal_posterior_eye1.22832740
78MP0001970_abnormal_pain_threshold1.21884540
79MP0002160_abnormal_reproductive_system1.20139604
80MP0002063_abnormal_learning/memory/cond1.17789573
81MP0003635_abnormal_synaptic_transmissio1.17558388
82MP0000465_gastrointestinal_hemorrhage1.16763061
83MP0008260_abnormal_autophagy1.16228469
84MP0001293_anophthalmia1.16196794
85MP0002398_abnormal_bone_marrow1.15812062
86MP0005646_abnormal_pituitary_gland1.15608213
87MP0003890_abnormal_embryonic-extraembry1.14687140
88MP0000049_abnormal_middle_ear1.13896444
89MP0006276_abnormal_autonomic_nervous1.13771691
90MP0002752_abnormal_somatic_nervous1.12655416
91MP0001984_abnormal_olfaction1.12299568
92MP0003011_delayed_dark_adaptation1.11803279
93MP0003718_maternal_effect1.10041761
94MP0002938_white_spotting1.09064357
95MP0005387_immune_system_phenotype1.08386551
96MP0001790_abnormal_immune_system1.08386551
97MP0000955_abnormal_spinal_cord1.08256634
98MP0002277_abnormal_respiratory_mucosa1.07507571
99MP0002282_abnormal_trachea_morphology1.07014599
100MP0001853_heart_inflammation1.06909240
101MP0002177_abnormal_outer_ear1.06886451
102MP0000490_abnormal_crypts_of1.06862708
103MP0003698_abnormal_male_reproductive1.06010513
104MP0002733_abnormal_thermal_nociception1.06001555
105MP0005389_reproductive_system_phenotype1.05295632
106MP0005171_absent_coat_pigmentation1.05266852
107MP0001905_abnormal_dopamine_level1.04928470
108MP0005379_endocrine/exocrine_gland_phen1.04850258
109MP0009333_abnormal_splenocyte_physiolog1.04579163
110MP0002184_abnormal_innervation1.03739755
111MP0000716_abnormal_immune_system1.03578982
112MP0001545_abnormal_hematopoietic_system1.03554052
113MP0005397_hematopoietic_system_phenotyp1.03554052
114MP0005386_behavior/neurological_phenoty1.02734317
115MP0004924_abnormal_behavior1.02734317
116MP0002751_abnormal_autonomic_nervous1.02323972
117MP0001968_abnormal_touch/_nociception0.98986759
118MP0000631_abnormal_neuroendocrine_gland0.98635508
119MP0002882_abnormal_neuron_morphology0.97226718
120MP0005464_abnormal_platelet_physiology0.96970896
121MP0001873_stomach_inflammation0.96145207
122MP0001324_abnormal_eye_pigmentation0.96080239
123MP0003937_abnormal_limbs/digits/tail_de0.95503483
124MP0000689_abnormal_spleen_morphology0.90406734
125MP0001929_abnormal_gametogenesis0.89479583
126MP0005645_abnormal_hypothalamus_physiol0.89170746
127MP0005391_vision/eye_phenotype0.89160335
128MP0005410_abnormal_fertilization0.89019863
129MP0000026_abnormal_inner_ear0.88778756
130MP0003786_premature_aging0.88632474
131MP0003938_abnormal_ear_development0.88438366
132MP0002429_abnormal_blood_cell0.87926884
133MP0000647_abnormal_sebaceous_gland0.87516442
134MP0003119_abnormal_digestive_system0.86518039
135MP0002210_abnormal_sex_determination0.86051271
136MP0002405_respiratory_system_inflammati0.85098029
137MP0002909_abnormal_adrenal_gland0.82678325
138MP0002249_abnormal_larynx_morphology0.82280431
139MP0005084_abnormal_gallbladder_morpholo0.82137366
140MP0002722_abnormal_immune_system0.81823993
141MP0002075_abnormal_coat/hair_pigmentati0.81132311
142MP0005551_abnormal_eye_electrophysiolog0.80721038
143MP0001486_abnormal_startle_reflex0.80695283
144MP0004808_abnormal_hematopoietic_stem0.80614976
145MP0002006_tumorigenesis0.79781145
146MP0009697_abnormal_copulation0.78652919
147MP0003866_abnormal_defecation0.77884218
148MP0002009_preneoplasia0.77176332
149MP0010386_abnormal_urinary_bladder0.76501678
150MP0002272_abnormal_nervous_system0.75122037
151MP0001186_pigmentation_phenotype0.73882683
152MP0001963_abnormal_hearing_physiology0.73165577
153MP0004145_abnormal_muscle_electrophysio0.72060000
154MP0002166_altered_tumor_susceptibility0.71865381
155MP0001502_abnormal_circadian_rhythm0.70865139
156MP0002067_abnormal_sensory_capabilities0.69118924
157MP0002736_abnormal_nociception_after0.68283093
158MP0000678_abnormal_parathyroid_gland0.67934277
159MP0005253_abnormal_eye_physiology0.67823205
160MP0002933_joint_inflammation0.66498922
161MP0008789_abnormal_olfactory_epithelium0.65717295
162MP0010155_abnormal_intestine_physiology0.65519628

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.65375604
2Abnormality of midbrain morphology (HP:0002418)4.62356534
3Molar tooth sign on MRI (HP:0002419)4.62356534
4Nephronophthisis (HP:0000090)4.40937938
5Aplastic anemia (HP:0001915)4.08722857
6Reduced antithrombin III activity (HP:0001976)4.06483210
7Abnormality of cells of the erythroid lineage (HP:0012130)3.77571734
8Abnormal number of erythroid precursors (HP:0012131)3.73120380
9Abnormality of the renal medulla (HP:0100957)3.72261627
10Cystic liver disease (HP:0006706)3.57884739
11Chronic hepatic failure (HP:0100626)3.56450234
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.49133528
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.42869235
14Absent/shortened dynein arms (HP:0200106)3.42869235
15Severe visual impairment (HP:0001141)3.34857955
16Abnormal protein N-linked glycosylation (HP:0012347)3.32245992
17Abnormal protein glycosylation (HP:0012346)3.32245992
18Abnormal glycosylation (HP:0012345)3.32245992
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.32245992
20Reticulocytopenia (HP:0001896)3.28669281
21Type II lissencephaly (HP:0007260)3.21533501
22Nonprogressive disorder (HP:0003680)3.20955317
23Tubular atrophy (HP:0000092)3.15439088
24Hypothermia (HP:0002045)3.13057053
25Congenital stationary night blindness (HP:0007642)3.05835629
26Abnormal ciliary motility (HP:0012262)3.04998057
27Abnormal respiratory epithelium morphology (HP:0012253)3.03673485
28Abnormal respiratory motile cilium morphology (HP:0005938)3.03673485
29Gait imbalance (HP:0002141)3.03157355
30Abnormality of the columella (HP:0009929)2.98691527
31Type 2 muscle fiber atrophy (HP:0003554)2.98460259
32Congenital primary aphakia (HP:0007707)2.95707797
33Abnormality of the renal cortex (HP:0011035)2.93793817
34Occipital encephalocele (HP:0002085)2.93131176
35True hermaphroditism (HP:0010459)2.91942607
36Bronchiectasis (HP:0002110)2.91121809
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.89261054
38Sclerocornea (HP:0000647)2.86898768
39Hyperventilation (HP:0002883)2.84658975
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.84142672
41Postaxial foot polydactyly (HP:0001830)2.81324115
42Chronic bronchitis (HP:0004469)2.77658202
43Thyroid-stimulating hormone excess (HP:0002925)2.74325720
44Abnormal respiratory motile cilium physiology (HP:0012261)2.74133661
45Elevated erythrocyte sedimentation rate (HP:0003565)2.73953949
46Cerebellar dysplasia (HP:0007033)2.73410037
47Polydipsia (HP:0001959)2.69274903
48Abnormal drinking behavior (HP:0030082)2.69274903
49Nephrogenic diabetes insipidus (HP:0009806)2.68821295
503-Methylglutaconic aciduria (HP:0003535)2.67759222
51Congenital hepatic fibrosis (HP:0002612)2.67348722
52Muscle fiber atrophy (HP:0100295)2.61370465
53Broad face (HP:0000283)2.60127005
54Abnormal rod and cone electroretinograms (HP:0008323)2.59856904
55Renal Fanconi syndrome (HP:0001994)2.59579850
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.57115669
57Increased hepatocellular lipid droplets (HP:0006565)2.55259265
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53748117
59Pallor (HP:0000980)2.53027564
60Abolished electroretinogram (ERG) (HP:0000550)2.52120686
61Abnormality of secondary sexual hair (HP:0009888)2.50790473
62Abnormality of the axillary hair (HP:0100134)2.50790473
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49905993
64Genital tract atresia (HP:0001827)2.48011378
65Myositis (HP:0100614)2.46894987
66Male pseudohermaphroditism (HP:0000037)2.44709501
67Pancreatic fibrosis (HP:0100732)2.44126311
68Vaginal atresia (HP:0000148)2.41958010
69Attenuation of retinal blood vessels (HP:0007843)2.40936047
70Dry hair (HP:0011359)2.35795103
71Chronic otitis media (HP:0000389)2.32846234
72IgM deficiency (HP:0002850)2.32285610
73Hepatocellular necrosis (HP:0001404)2.31989524
74Recurrent abscess formation (HP:0002722)2.30982510
75Postaxial hand polydactyly (HP:0001162)2.30699641
76Furrowed tongue (HP:0000221)2.30588877
77Petechiae (HP:0000967)2.27298488
78Thrombocytosis (HP:0001894)2.22681848
79Abnormal biliary tract physiology (HP:0012439)2.22159570
80Bile duct proliferation (HP:0001408)2.22159570
81Prolonged bleeding time (HP:0003010)2.22134821
82Exertional dyspnea (HP:0002875)2.20771009
83Pancreatic cysts (HP:0001737)2.20636194
84Decreased central vision (HP:0007663)2.18610001
85Poor coordination (HP:0002370)2.17998128
86Preaxial hand polydactyly (HP:0001177)2.17458361
87Mitochondrial inheritance (HP:0001427)2.16170731
88Decreased circulating renin level (HP:0003351)2.15557816
89Lissencephaly (HP:0001339)2.15346587
90Bony spicule pigmentary retinopathy (HP:0007737)2.14023404
91Microvesicular hepatic steatosis (HP:0001414)2.12841584
92Meningitis (HP:0001287)2.11252650
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11044547
94Macrocytic anemia (HP:0001972)2.10088547
95Polyuria (HP:0000103)2.09850912
96Chronic sinusitis (HP:0011109)2.09642145
97Agammaglobulinemia (HP:0004432)2.09159426
98Pendular nystagmus (HP:0012043)2.07954708
99Panhypogammaglobulinemia (HP:0003139)2.07813879
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06607778
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06607778
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06481232
103Patchy hypopigmentation of hair (HP:0011365)2.05954927
104Hypoproteinemia (HP:0003075)2.05678458
105Pancytopenia (HP:0001876)2.04508198
106Lipid accumulation in hepatocytes (HP:0006561)2.03755898
107Progressive cerebellar ataxia (HP:0002073)2.00204657
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.97985481
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.97714503
110Chronic mucocutaneous candidiasis (HP:0002728)1.97407393
111Recurrent cutaneous fungal infections (HP:0011370)1.97407393
112Abnormality of DNA repair (HP:0003254)1.97284028
113Broad-based gait (HP:0002136)1.94339876
114Chromsome breakage (HP:0040012)1.92897384
115Tubulointerstitial abnormality (HP:0001969)1.91153034
116Recurrent sinusitis (HP:0011108)1.90951666
117Genetic anticipation (HP:0003743)1.89733499
118Tubulointerstitial nephritis (HP:0001970)1.88686198
119Abnormality of the labia minora (HP:0012880)1.88026889
120Absent speech (HP:0001344)1.87581111
121Rhinitis (HP:0012384)1.87200608
122Medial flaring of the eyebrow (HP:0010747)1.86818802
123Retinal dysplasia (HP:0007973)1.86562575
124Abnormality of B cell number (HP:0010975)1.86188779
125B lymphocytopenia (HP:0010976)1.86188779
126Abnormality of renal resorption (HP:0011038)1.85593686
127Increased corneal curvature (HP:0100692)1.84634592
128Keratoconus (HP:0000563)1.84634592
129Obstructive lung disease (HP:0006536)1.84059105
130Chronic obstructive pulmonary disease (HP:0006510)1.84059105
131Oligodactyly (hands) (HP:0001180)1.83178959
132Inability to walk (HP:0002540)1.82346011
133Febrile seizures (HP:0002373)1.82302599
134Dandy-Walker malformation (HP:0001305)1.82266009
135Abnormality of the prostate (HP:0008775)1.81790330
136Asplenia (HP:0001746)1.81456723
137Retinitis pigmentosa (HP:0000510)1.80270188
138Increased intramyocellular lipid droplets (HP:0012240)1.79742237
139Recurrent bacterial skin infections (HP:0005406)1.78739051
140Optic neuritis (HP:0100653)1.78553401
141Retrobulbar optic neuritis (HP:0100654)1.78553401
142Gaze-evoked nystagmus (HP:0000640)1.78466945
143Protruding tongue (HP:0010808)1.78392061
144Stomatitis (HP:0010280)1.77695110
145Abnormality of magnesium homeostasis (HP:0004921)1.76892148
146White forelock (HP:0002211)1.75929870
147Optic nerve hypoplasia (HP:0000609)1.75508998
148Acute necrotizing encephalopathy (HP:0006965)1.75305494
149Narrow forehead (HP:0000341)1.74354843
150Anophthalmia (HP:0000528)1.73727282
151Optic disc pallor (HP:0000543)1.73582455
152Albinism (HP:0001022)1.73445800
153Median cleft lip (HP:0000161)1.73262179
154Abnormality of the preputium (HP:0100587)1.73080046
155Clubbing of toes (HP:0100760)1.73068816
156Recurrent bronchitis (HP:0002837)1.72945112
157Oculomotor apraxia (HP:0000657)1.72924486
158Pachygyria (HP:0001302)1.72454378
159Multicystic kidney dysplasia (HP:0000003)1.72282606
160Mediastinal lymphadenopathy (HP:0100721)1.72118570
161Supernumerary spleens (HP:0009799)1.71880157
162Aganglionic megacolon (HP:0002251)1.70725139
163Increased CSF lactate (HP:0002490)1.70207183
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69463915
165Hepatic necrosis (HP:0002605)1.69463167
166Infertility (HP:0000789)1.69313209
167Specific learning disability (HP:0001328)1.69282625
168Anencephaly (HP:0002323)1.69227762
169Intestinal atresia (HP:0011100)1.66352025
170Patellar aplasia (HP:0006443)1.64845591
171Astigmatism (HP:0000483)1.63894835
172Abnormal urine output (HP:0012590)1.63312214
173Focal motor seizures (HP:0011153)1.62387219
174Tubulointerstitial fibrosis (HP:0005576)1.62149575
175Focal seizures (HP:0007359)1.61778621
176Stage 5 chronic kidney disease (HP:0003774)1.60519714
177Highly arched eyebrow (HP:0002553)1.59757613
178Polyphagia (HP:0002591)1.58319697
179Congenital, generalized hypertrichosis (HP:0004540)1.57918207
180Renal cortical cysts (HP:0000803)1.57797463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.83194923
2FRK5.61621923
3MUSK4.40142249
4STK164.29913625
5CASK3.32933181
6WNK32.77148731
7MAP4K22.74446271
8NME22.71355343
9MKNK22.55649215
10INSRR2.22694706
11MAP3K42.19649516
12IRAK42.10898638
13CDK192.02368311
14KIT1.96560056
15TEC1.95435689
16WNK41.92758015
17NLK1.92622513
18MAP2K71.90685226
19PNCK1.81977587
20MKNK11.80765047
21MARK11.77728203
22VRK11.64701892
23ADRBK21.64653044
24MAP3K121.62688190
25PIM21.60007072
26EIF2AK31.58083988
27IRAK31.56127618
28CAMKK21.51469939
29OXSR11.47439719
30CAMK11.43052526
31TXK1.41231624
32BLK1.39286267
33BCR1.38059095
34SRPK11.38025286
35MAPK151.33086077
36BTK1.32464175
37STK391.29179323
38YES11.27208014
39EIF2AK21.27051590
40FES1.24640939
41MAP3K141.22140533
42TLK11.21282338
43WEE11.17297641
44BMPR1B1.16216929
45PTK2B1.15934366
46FLT31.14802358
47IRAK11.14089231
48PAK31.13165503
49GRK71.12705858
50MAPKAPK51.11775152
51IKBKE1.10441034
52TRIM281.10204433
53DYRK31.09554954
54NTRK21.09159356
55CLK11.07556617
56MAPK131.07538812
57ADRBK11.06416329
58IKBKB1.04925095
59CDK31.02546209
60ACVR1B0.99052263
61TIE10.98357559
62PRKCG0.96681787
63EPHA40.96116126
64PLK20.95878015
65STK38L0.94659114
66TBK10.94205548
67DAPK20.94123697
68PRKCE0.92873995
69FGFR20.90705514
70TNK20.90530044
71CSNK1G20.89491454
72IRAK20.88981586
73SYK0.87884664
74LYN0.84055071
75GRK10.83501948
76MARK20.82911782
77CSF1R0.79042700
78RIPK40.78934385
79CSNK1A1L0.78494301
80SIK30.73735924
81PIK3CA0.73368887
82KDR0.72938235
83NEK20.72918032
84STK110.68823351
85TGFBR20.68635744
86CCNB10.67471227
87MAP4K10.67283250
88BMPR20.67188308
89ERBB30.66091306
90NME10.65838751
91EPHA30.65743066
92AKT30.65653976
93MAP3K70.65630300
94ZAK0.64906877
95MAPKAPK30.64387276
96NTRK30.61933070
97CAMK40.60918607
98CDK80.60715710
99BCKDK0.59992972
100MST40.59743422
101PINK10.59125117
102JAK30.57203387
103MAP2K40.56761503
104MARK30.54967436
105BRSK20.54862766
106LCK0.54662474
107TAOK20.53592770
108CAMK2A0.53279991
109CAMK1G0.53115564
110PLK40.51728656
111ZAP700.51378851
112PRKG20.50167165
113MATK0.50144072
114PRKCI0.50016134
115ERBB20.49921004
116PKN10.49848591
117NEK60.49068466
118DYRK20.48561917
119PRKACA0.48536883
120PRKCZ0.48131809
121MAPK40.47879029
122TSSK60.47765368
123HIPK20.47525621
124PRKAA10.47339554
125CAMK1D0.46145387
126PRKCQ0.46116950
127CSNK1G10.45528686
128MAP2K60.45291640
129PHKG20.44233401
130PHKG10.44233401
131CDK70.44002820
132TGFBR10.43306050
133PLK30.43061602
134CSNK1A10.42560831
135RPS6KA50.39854350
136TAOK30.39583270
137CHUK0.39010439
138PLK10.38268089
139MAP3K60.37640876
140PRKG10.37474050
141MYLK0.37032120
142CSNK1G30.36796703
143CHEK20.36147780
144STK30.35853240
145CAMKK10.35809866
146MAP2K20.35418056
147PRKAA20.35142065
148CAMK2D0.34249153
149PIK3CG0.31860825
150PRKD20.31768931
151HCK0.29903128
152SIK20.29616246
153DYRK1A0.28153365
154NUAK10.27607440
155TYK20.27459212
156CSNK2A10.27102440
157CAMK2B0.26377927
158PIM10.25690930
159MAP2K30.24578621
160ATR0.22616858

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16580475
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87495827
3DNA replication_Homo sapiens_hsa030302.75492526
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.70974512
5Protein export_Homo sapiens_hsa030602.63230919
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.62251774
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53323164
8Homologous recombination_Homo sapiens_hsa034402.52013170
9Butanoate metabolism_Homo sapiens_hsa006502.33487106
10Fanconi anemia pathway_Homo sapiens_hsa034602.21409644
11RNA polymerase_Homo sapiens_hsa030202.19891070
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18977938
13Nitrogen metabolism_Homo sapiens_hsa009102.00924136
14Pyrimidine metabolism_Homo sapiens_hsa002401.98632562
15Primary immunodeficiency_Homo sapiens_hsa053401.89030325
16Caffeine metabolism_Homo sapiens_hsa002321.80951975
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.79268858
18Base excision repair_Homo sapiens_hsa034101.75871966
19Mismatch repair_Homo sapiens_hsa034301.73701823
20Tryptophan metabolism_Homo sapiens_hsa003801.64946432
21Selenocompound metabolism_Homo sapiens_hsa004501.63810374
22Phototransduction_Homo sapiens_hsa047441.55519737
23Allograft rejection_Homo sapiens_hsa053301.53522051
24Non-homologous end-joining_Homo sapiens_hsa034501.52037523
25Chemical carcinogenesis_Homo sapiens_hsa052041.50020739
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49353798
27Basal transcription factors_Homo sapiens_hsa030221.48007120
28Spliceosome_Homo sapiens_hsa030401.47829523
29Proteasome_Homo sapiens_hsa030501.47720030
30ABC transporters_Homo sapiens_hsa020101.46521696
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44796386
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44773093
33Purine metabolism_Homo sapiens_hsa002301.44420108
34Nucleotide excision repair_Homo sapiens_hsa034201.44400861
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41248409
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41004151
37N-Glycan biosynthesis_Homo sapiens_hsa005101.39048748
38Oxidative phosphorylation_Homo sapiens_hsa001901.36784949
39Propanoate metabolism_Homo sapiens_hsa006401.34429393
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33973904
41Sphingolipid metabolism_Homo sapiens_hsa006001.33203187
42Other glycan degradation_Homo sapiens_hsa005111.32527081
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32227209
44Hematopoietic cell lineage_Homo sapiens_hsa046401.30992489
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30992364
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.29233785
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28522884
48Asthma_Homo sapiens_hsa053101.26805930
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.26543071
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.25620470
51GABAergic synapse_Homo sapiens_hsa047271.23620040
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20768320
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19262254
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18747497
55Retinol metabolism_Homo sapiens_hsa008301.18734370
56Insulin secretion_Homo sapiens_hsa049111.18450785
57Steroid biosynthesis_Homo sapiens_hsa001001.16725650
58Nicotine addiction_Homo sapiens_hsa050331.15943271
59beta-Alanine metabolism_Homo sapiens_hsa004101.14573192
60Peroxisome_Homo sapiens_hsa041461.14433589
61Cardiac muscle contraction_Homo sapiens_hsa042601.10913420
62Histidine metabolism_Homo sapiens_hsa003401.10726174
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.09225448
64Arachidonic acid metabolism_Homo sapiens_hsa005901.07763279
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07652197
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07421234
67Measles_Homo sapiens_hsa051621.06954812
68Herpes simplex infection_Homo sapiens_hsa051681.04716000
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02962000
70RNA degradation_Homo sapiens_hsa030181.01787884
71Parkinsons disease_Homo sapiens_hsa050121.00688393
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98427270
73Graft-versus-host disease_Homo sapiens_hsa053320.95534460
74Autoimmune thyroid disease_Homo sapiens_hsa053200.95332425
75Leishmaniasis_Homo sapiens_hsa051400.95294063
76Ovarian steroidogenesis_Homo sapiens_hsa049130.93201867
77Salivary secretion_Homo sapiens_hsa049700.92294059
78Huntingtons disease_Homo sapiens_hsa050160.90133753
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89262059
80Glycerolipid metabolism_Homo sapiens_hsa005610.87832364
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.84837324
82Hedgehog signaling pathway_Homo sapiens_hsa043400.83853864
83Ether lipid metabolism_Homo sapiens_hsa005650.82830529
84Malaria_Homo sapiens_hsa051440.79453539
85Alzheimers disease_Homo sapiens_hsa050100.78427162
86Taste transduction_Homo sapiens_hsa047420.77993137
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77791067
88Dopaminergic synapse_Homo sapiens_hsa047280.75856394
89Cocaine addiction_Homo sapiens_hsa050300.73826282
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73711537
91Basal cell carcinoma_Homo sapiens_hsa052170.72979999
92Folate biosynthesis_Homo sapiens_hsa007900.71844245
93B cell receptor signaling pathway_Homo sapiens_hsa046620.70997985
94Rheumatoid arthritis_Homo sapiens_hsa053230.70540188
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68781050
96Sulfur relay system_Homo sapiens_hsa041220.67135461
97Fat digestion and absorption_Homo sapiens_hsa049750.64781101
98Serotonergic synapse_Homo sapiens_hsa047260.62474459
99Axon guidance_Homo sapiens_hsa043600.61189142
100Pertussis_Homo sapiens_hsa051330.61120611
101cAMP signaling pathway_Homo sapiens_hsa040240.59029478
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58706091
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57699481
104Regulation of autophagy_Homo sapiens_hsa041400.57461467
105Amphetamine addiction_Homo sapiens_hsa050310.57079987
106Collecting duct acid secretion_Homo sapiens_hsa049660.56911151
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56203004
108African trypanosomiasis_Homo sapiens_hsa051430.55789440
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55546359
110Type I diabetes mellitus_Homo sapiens_hsa049400.54248227
111Morphine addiction_Homo sapiens_hsa050320.53873189
112Calcium signaling pathway_Homo sapiens_hsa040200.52569303
113One carbon pool by folate_Homo sapiens_hsa006700.52399019
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.52147979
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52102580
116Cholinergic synapse_Homo sapiens_hsa047250.51970237
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51749867
118Fatty acid degradation_Homo sapiens_hsa000710.50259859
119Linoleic acid metabolism_Homo sapiens_hsa005910.49801727
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49210304
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48288742
122Glutamatergic synapse_Homo sapiens_hsa047240.48050712
123Olfactory transduction_Homo sapiens_hsa047400.47572143
124Long-term depression_Homo sapiens_hsa047300.43953473
125Systemic lupus erythematosus_Homo sapiens_hsa053220.43619887
126Alcoholism_Homo sapiens_hsa050340.43576990
127Epstein-Barr virus infection_Homo sapiens_hsa051690.43482669
128Influenza A_Homo sapiens_hsa051640.43325420
129Antigen processing and presentation_Homo sapiens_hsa046120.42569090
130Osteoclast differentiation_Homo sapiens_hsa043800.41444612
131p53 signaling pathway_Homo sapiens_hsa041150.41355995
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40640026
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.40602749
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.38652147
135Metabolic pathways_Homo sapiens_hsa011000.37954308
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37900780
137Hippo signaling pathway_Homo sapiens_hsa043900.37328433
138Mineral absorption_Homo sapiens_hsa049780.36403167
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36205507
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36045646
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36011555
142Oxytocin signaling pathway_Homo sapiens_hsa049210.35932263
143Acute myeloid leukemia_Homo sapiens_hsa052210.35714756
144Gastric acid secretion_Homo sapiens_hsa049710.34316531
145Tuberculosis_Homo sapiens_hsa051520.33906774
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.33838774
147Fatty acid biosynthesis_Homo sapiens_hsa000610.33616207
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33168501
149Circadian rhythm_Homo sapiens_hsa047100.33132037
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30708872
151T cell receptor signaling pathway_Homo sapiens_hsa046600.29014159
152Salmonella infection_Homo sapiens_hsa051320.26048236
153Cell cycle_Homo sapiens_hsa041100.24999078
154Vitamin digestion and absorption_Homo sapiens_hsa049770.22298562
155Circadian entrainment_Homo sapiens_hsa047130.22227750

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