FAM227B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.99367185
2reproduction (GO:0000003)9.20170031
3male meiosis (GO:0007140)9.12593468
4spermatid development (GO:0007286)9.01064676
5motile cilium assembly (GO:0044458)9.00000235
6cilium movement (GO:0003341)8.96754580
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.77427092
8regulation of cilium movement (GO:0003352)8.08556590
9synaptonemal complex organization (GO:0070193)7.96938664
10synaptonemal complex assembly (GO:0007130)7.72962796
11single fertilization (GO:0007338)7.47761919
12sperm capacitation (GO:0048240)7.06729264
13DNA methylation involved in gamete generation (GO:0043046)6.42015151
14fertilization (GO:0009566)6.37462108
15negative regulation of inclusion body assembly (GO:0090084)6.24297509
16spermatogenesis (GO:0007283)5.96430943
17male gamete generation (GO:0048232)5.94154435
18ventricular system development (GO:0021591)5.87718212
19male meiosis I (GO:0007141)5.79455753
20gamete generation (GO:0007276)5.47602652
21chromosome organization involved in meiosis (GO:0070192)5.42708894
22organic cation transport (GO:0015695)5.27621439
23cellular process involved in reproduction in multicellular organism (GO:0022412)5.23507433
24germ cell development (GO:0007281)5.18206361
25cell recognition (GO:0008037)5.12216670
26meiotic nuclear division (GO:0007126)5.07512132
27microtubule depolymerization (GO:0007019)5.07022880
28regulation of inclusion body assembly (GO:0090083)5.04321997
29calcium ion-dependent exocytosis (GO:0017156)5.01309176
30microtubule severing (GO:0051013)4.99414070
31spermatid nucleus differentiation (GO:0007289)4.76949775
32regulation of microtubule-based movement (GO:0060632)4.76876101
33meiosis I (GO:0007127)4.64471361
34seminiferous tubule development (GO:0072520)4.51292894
35protein localization to cilium (GO:0061512)4.45228526
36multicellular organismal reproductive process (GO:0048609)4.29596608
37meiotic cell cycle (GO:0051321)4.25400824
38left/right pattern formation (GO:0060972)4.24417585
39protein complex biogenesis (GO:0070271)4.21295175
40mitochondrial respiratory chain complex I assembly (GO:0032981)4.11878831
41NADH dehydrogenase complex assembly (GO:0010257)4.11878831
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11878831
43protein polyglutamylation (GO:0018095)4.01564651
44genitalia morphogenesis (GO:0035112)3.87990520
45DNA deamination (GO:0045006)3.85549983
46mitochondrial respiratory chain complex assembly (GO:0033108)3.84387477
47intraciliary transport (GO:0042073)3.83982609
48platelet dense granule organization (GO:0060155)3.77657513
49monoubiquitinated protein deubiquitination (GO:0035520)3.69452869
50chaperone-mediated protein complex assembly (GO:0051131)3.60955042
51respiratory chain complex IV assembly (GO:0008535)3.60754563
52behavioral response to nicotine (GO:0035095)3.57963622
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56375616
54maturation of 5.8S rRNA (GO:0000460)3.49076710
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46187426
56axoneme assembly (GO:0035082)3.44931145
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.44387394
58microtubule-based movement (GO:0007018)3.44253453
59multicellular organismal development (GO:0007275)3.42893368
60negative regulation of organelle assembly (GO:1902116)3.42227790
61response to pheromone (GO:0019236)3.40324036
62water-soluble vitamin biosynthetic process (GO:0042364)3.38914589
63neural tube formation (GO:0001841)3.37549374
64gene silencing by RNA (GO:0031047)3.32687452
65protein K11-linked deubiquitination (GO:0035871)3.31201657
66carnitine transport (GO:0015879)3.29476866
67amino-acid betaine transport (GO:0015838)3.29476866
68carnitine transmembrane transport (GO:1902603)3.29264367
69cytochrome complex assembly (GO:0017004)3.29082985
70synapsis (GO:0007129)3.27745923
71nonmotile primary cilium assembly (GO:0035058)3.24282665
72cilium organization (GO:0044782)3.21882459
73cilium morphogenesis (GO:0060271)3.11753474
74centriole replication (GO:0007099)3.06175833
75meiotic cell cycle process (GO:1903046)3.04425694
76glycerol ether metabolic process (GO:0006662)3.04357172
77nucleoside diphosphate phosphorylation (GO:0006165)3.04041850
78cilium assembly (GO:0042384)3.04032083
79cellular component assembly involved in morphogenesis (GO:0010927)3.03764066
80chromosome condensation (GO:0030261)3.02715327
81protein-cofactor linkage (GO:0018065)3.02076629
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00369398
83protein neddylation (GO:0045116)3.00181905
84ubiquinone biosynthetic process (GO:0006744)2.98367018
85indolalkylamine metabolic process (GO:0006586)2.97909591
86cellular ketone body metabolic process (GO:0046950)2.97769535
87fucose catabolic process (GO:0019317)2.95303804
88L-fucose metabolic process (GO:0042354)2.95303804
89L-fucose catabolic process (GO:0042355)2.95303804
90regulation of centriole replication (GO:0046599)2.94860314
91DNA double-strand break processing (GO:0000729)2.94407986
92sulfation (GO:0051923)2.93145663
93proteasome assembly (GO:0043248)2.91718551
94DNA packaging (GO:0006323)2.90038462
95negative regulation of protein oligomerization (GO:0032460)2.87567817
96mannosylation (GO:0097502)2.87098616
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87066526
98lactate metabolic process (GO:0006089)2.87036279
99protein refolding (GO:0042026)2.86722504
100regulation of spindle checkpoint (GO:0090231)2.86145824
101centriole assembly (GO:0098534)2.85939308
102alditol metabolic process (GO:0019400)2.84686456
103ATP synthesis coupled proton transport (GO:0015986)2.84177041
104energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84177041
105intracellular protein transmembrane import (GO:0044743)2.83086544
106tryptophan catabolic process (GO:0006569)2.82133281
107indole-containing compound catabolic process (GO:0042436)2.82133281
108indolalkylamine catabolic process (GO:0046218)2.82133281
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80660547
110ether metabolic process (GO:0018904)2.80263211
111ubiquinone metabolic process (GO:0006743)2.80244162
112electron transport chain (GO:0022900)2.79715312
113replication fork processing (GO:0031297)2.79208526
114regulation of rhodopsin mediated signaling pathway (GO:0022400)2.79088701
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78773606
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.78773606
117regulation of hexokinase activity (GO:1903299)2.78042997
118regulation of glucokinase activity (GO:0033131)2.78042997
119anterograde synaptic vesicle transport (GO:0048490)2.78018712
120photoreceptor cell maintenance (GO:0045494)2.77833435
121rhodopsin mediated signaling pathway (GO:0016056)2.77530267
122respiratory electron transport chain (GO:0022904)2.76640248
123inositol phosphate catabolic process (GO:0071545)2.75941993
124regulation of hippo signaling (GO:0035330)2.75241200
125polyol catabolic process (GO:0046174)2.74640004
126microtubule polymerization or depolymerization (GO:0031109)2.71726755
127adaptation of signaling pathway (GO:0023058)2.69609638
128chaperone-mediated protein transport (GO:0072321)2.69272268
129cornea development in camera-type eye (GO:0061303)2.68478832
130GTP biosynthetic process (GO:0006183)2.66438733
131nucleotide transmembrane transport (GO:1901679)2.65470928
132protein import into peroxisome matrix (GO:0016558)2.65180849
133peptidyl-glutamic acid modification (GO:0018200)2.64109697
134regulation of meiosis I (GO:0060631)2.62604115
135protein prenylation (GO:0018342)2.61981418
136prenylation (GO:0097354)2.61981418
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60893630
138negative regulation of mast cell activation (GO:0033004)2.60579475
139glycerol metabolic process (GO:0006071)2.59843678
140regulation of protein polyubiquitination (GO:1902914)2.59738725
141ketone body metabolic process (GO:1902224)2.59629248
142termination of RNA polymerase III transcription (GO:0006386)2.59332296
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.59332296
144positive regulation of meiosis (GO:0045836)2.58853448
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58670815
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58670815
147recombinational repair (GO:0000725)2.58309924
148double-strand break repair via homologous recombination (GO:0000724)2.58000268
149kynurenine metabolic process (GO:0070189)2.56423655
150single strand break repair (GO:0000012)2.55494345
151retinal ganglion cell axon guidance (GO:0031290)2.55385597
152nucleus organization (GO:0006997)2.51755118
153protein K6-linked ubiquitination (GO:0085020)2.47965639
154negative regulation of telomere maintenance (GO:0032205)2.47256607
155glycolytic process (GO:0006096)2.46210737
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45637451
157inositol phosphate dephosphorylation (GO:0046855)2.45637451
158behavioral response to ethanol (GO:0048149)2.44656663
159reciprocal DNA recombination (GO:0035825)2.44277761
160reciprocal meiotic recombination (GO:0007131)2.44277761
161tryptophan metabolic process (GO:0006568)2.43819899
162dopamine transport (GO:0015872)2.43132139
163negative regulation of skeletal muscle tissue development (GO:0048642)2.41989873
164preassembly of GPI anchor in ER membrane (GO:0016254)2.41539821
165mitotic sister chromatid cohesion (GO:0007064)2.40073132
166calcium ion import (GO:0070509)2.34260113
167gene silencing (GO:0016458)2.33931295
168left/right axis specification (GO:0070986)2.32282619
169DNA alkylation (GO:0006305)2.29864935
170cilium or flagellum-dependent cell motility (GO:0001539)14.6905461
171fusion of sperm to egg plasma membrane (GO:0007342)13.2100130
172sperm motility (GO:0030317)12.3385528
173acrosome assembly (GO:0001675)12.1309817
174multicellular organism reproduction (GO:0032504)11.2429267
175sperm-egg recognition (GO:0035036)11.2321261
176acrosome reaction (GO:0007340)10.8776001
177cell wall macromolecule catabolic process (GO:0016998)10.7964320
178cell wall macromolecule metabolic process (GO:0044036)10.7964320
179axonemal dynein complex assembly (GO:0070286)10.7206063
180binding of sperm to zona pellucida (GO:0007339)10.1818863
181epithelial cilium movement (GO:0003351)10.1779690
182plasma membrane fusion (GO:0045026)10.0590739
183cell-cell recognition (GO:0009988)10.0068345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.29802440
2EZH2_22144423_ChIP-Seq_EOC_Human5.62471441
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.73294925
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20415155
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00180247
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67961098
7IGF1R_20145208_ChIP-Seq_DFB_Human2.62328832
8GBX2_23144817_ChIP-Seq_PC3_Human2.61008817
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56312081
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53879255
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.53451586
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38602965
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37574165
14EWS_26573619_Chip-Seq_HEK293_Human2.33488618
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33198160
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32615693
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26843326
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.24730777
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.23956192
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10890010
21P300_19829295_ChIP-Seq_ESCs_Human2.10537958
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09468723
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07615843
24VDR_22108803_ChIP-Seq_LS180_Human2.07337602
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05404827
26ZNF274_21170338_ChIP-Seq_K562_Hela2.02464954
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97854044
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93970547
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.88723702
30ELK1_19687146_ChIP-ChIP_HELA_Human1.76977938
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75235642
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74711777
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.73051291
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70729934
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.69616248
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69109660
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68023447
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66677692
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65407157
40IRF1_19129219_ChIP-ChIP_H3396_Human1.63830285
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62613989
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58267400
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57582879
44KDM2B_26808549_Chip-Seq_REH_Human1.54276411
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.54266731
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52121143
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51925155
48STAT1_17558387_ChIP-Seq_HELA_Human1.49873946
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48746062
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.48704466
51MYC_18940864_ChIP-ChIP_HL60_Human1.48640456
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48494363
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48374005
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47276718
55VDR_23849224_ChIP-Seq_CD4+_Human1.45951552
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44136138
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44065345
58TP53_22573176_ChIP-Seq_HFKS_Human1.43331787
59RNF2_27304074_Chip-Seq_NSC_Mouse1.43254471
60STAT3_23295773_ChIP-Seq_U87_Human1.40148240
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.38707902
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38520547
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38152666
64CBP_20019798_ChIP-Seq_JUKART_Human1.38152666
65AR_25329375_ChIP-Seq_VCAP_Human1.37040671
66REST_21632747_ChIP-Seq_MESCs_Mouse1.36561003
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.36093399
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.34917806
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.34578191
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34527577
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33652738
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33450119
73SOX2_19829295_ChIP-Seq_ESCs_Human1.33358972
74NANOG_19829295_ChIP-Seq_ESCs_Human1.33358972
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31939123
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.30682750
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29177194
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.27292842
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.27198559
80P53_22387025_ChIP-Seq_ESCs_Mouse1.26943893
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25786855
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.25735280
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25735280
84TCF4_22108803_ChIP-Seq_LS180_Human1.24028549
85P300_18555785_Chip-Seq_ESCs_Mouse1.23906149
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22160578
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.21824869
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21478312
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.21192517
90FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20782097
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.20433988
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20401920
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.19598535
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.19260504
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19225061
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19205976
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18614757
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18329872
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18329872
100SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17794818
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.17413329
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16987884
103RUNX2_22187159_ChIP-Seq_PCA_Human1.16744569
104GATA3_21867929_ChIP-Seq_TH1_Mouse1.16135057
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15120585
106AR_20517297_ChIP-Seq_VCAP_Human1.14636658
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13927373
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.13862928
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13333639
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13250852
111SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12748066
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12674271
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11214478
114TAF15_26573619_Chip-Seq_HEK293_Human1.10614244
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09856980
116PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09512753
117SRF_21415370_ChIP-Seq_HL-1_Mouse1.08801348
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08460938
119GF1_26923725_Chip-Seq_HPCs_Mouse1.08029131
120ER_23166858_ChIP-Seq_MCF-7_Human1.07967583
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07683399
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06841974
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.06406694
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05895911
125NCOR_22424771_ChIP-Seq_293T_Human1.05596869
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05518426
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.05044112
128JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04836663
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04595167
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02378281
131CDX2_22108803_ChIP-Seq_LS180_Human1.01695721
132PU1_27457419_Chip-Seq_LIVER_Mouse1.01626035
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01226333
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00746297
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00562156
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.00459517
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.99953528
138P53_21459846_ChIP-Seq_SAOS-2_Human0.99259565
139FOXP3_21729870_ChIP-Seq_TREG_Human0.99236804
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98667347
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98401563
142NMYC_18555785_Chip-Seq_ESCs_Mouse0.97083903
143TCF4_23295773_ChIP-Seq_U87_Human0.96640104
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.96452940
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95664075
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94464655
147FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93660778
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.93320695
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92745568
150FUS_26573619_Chip-Seq_HEK293_Human0.90298155
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.90137374
152SMAD4_21799915_ChIP-Seq_A2780_Human0.89125487
153BCAT_22108803_ChIP-Seq_LS180_Human0.88633496
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88479246
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88125695
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.86933974
157TBL1_22424771_ChIP-Seq_293T_Human0.85173218
158SOX9_26525672_Chip-Seq_HEART_Mouse0.84685288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.83287846
2MP0001929_abnormal_gametogenesis5.30860315
3MP0008877_abnormal_DNA_methylation4.75442038
4MP0002210_abnormal_sex_determination3.73570616
5MP0002161_abnormal_fertility/fecundity3.10632753
6MP0002653_abnormal_ependyma_morphology3.07145289
7MP0001145_abnormal_male_reproductive3.06807019
8MP0006292_abnormal_olfactory_placode2.73331660
9MP0000653_abnormal_sex_gland2.68492167
10MP0005623_abnormal_meninges_morphology2.63879180
11MP0002837_dystrophic_cardiac_calcinosis2.51912624
12MP0003787_abnormal_imprinting2.51472829
13MP0003880_abnormal_central_pattern2.29751513
14MP0002160_abnormal_reproductive_system2.05687933
15MP0006072_abnormal_retinal_apoptosis2.04742281
16MP0005410_abnormal_fertilization14.9286535
17MP0004133_heterotaxia1.93143622
18MP0005670_abnormal_white_adipose1.88458395
19MP0001529_abnormal_vocalization1.86789073
20MP0009046_muscle_twitch1.84773489
21MP0000372_irregular_coat_pigmentation1.80547687
22MP0002938_white_spotting1.79615254
23MP0003195_calcinosis1.78391036
24MP0003890_abnormal_embryonic-extraembry1.75629742
25MP0004142_abnormal_muscle_tone1.74333905
26MP0002254_reproductive_system_inflammat1.69932359
27MP0008789_abnormal_olfactory_epithelium1.69720139
28MP0001968_abnormal_touch/_nociception1.65158269
29MP0000631_abnormal_neuroendocrine_gland1.63032978
30MP0003646_muscle_fatigue1.62689326
31MP0001485_abnormal_pinna_reflex1.61486933
32MP0003718_maternal_effect1.59054793
33MP0002638_abnormal_pupillary_reflex1.55552875
34MP0004145_abnormal_muscle_electrophysio1.55076049
35MP0003121_genomic_imprinting1.45517731
36MP0002282_abnormal_trachea_morphology1.43072750
37MP0008875_abnormal_xenobiotic_pharmacok1.40475134
38MP0001764_abnormal_homeostasis1.34936432
39MP0004147_increased_porphyrin_level1.34721424
40MP0001984_abnormal_olfaction1.33321793
41MP0008872_abnormal_physiological_respon1.32499744
42MP0004885_abnormal_endolymph1.26763217
43MP0010386_abnormal_urinary_bladder1.24395382
44MP0005647_abnormal_sex_gland1.17267341
45MP0005394_taste/olfaction_phenotype1.13366757
46MP0005499_abnormal_olfactory_system1.13366757
47MP0004215_abnormal_myocardial_fiber1.12042602
48MP0003122_maternal_imprinting1.10476152
49MP0002277_abnormal_respiratory_mucosa1.08229117
50MP0002735_abnormal_chemical_nociception1.05646421
51MP0004233_abnormal_muscle_weight1.04160735
52MP0003011_delayed_dark_adaptation1.02870659
53MP0001986_abnormal_taste_sensitivity1.02420953
54MP0000383_abnormal_hair_follicle1.01604878
55MP0001905_abnormal_dopamine_level1.01556260
56MP0005379_endocrine/exocrine_gland_phen1.00642809
57MP0003950_abnormal_plasma_membrane0.97464579
58MP0005389_reproductive_system_phenotype0.96641517
59MP0005174_abnormal_tail_pigmentation0.94750131
60MP0003567_abnormal_fetal_cardiomyocyte0.94351923
61MP0003119_abnormal_digestive_system0.94250208
62MP0005084_abnormal_gallbladder_morpholo0.93913389
63MP0001765_abnormal_ion_homeostasis0.92653287
64MP0008057_abnormal_DNA_replication0.92452223
65MP0002067_abnormal_sensory_capabilities0.92181224
66MP0004043_abnormal_pH_regulation0.88869534
67MP0001970_abnormal_pain_threshold0.86625515
68MP0002751_abnormal_autonomic_nervous0.86576034
69MP0009697_abnormal_copulation0.86470543
70MP0001919_abnormal_reproductive_system0.84348311
71MP0002095_abnormal_skin_pigmentation0.83332728
72MP0003937_abnormal_limbs/digits/tail_de0.83231560
73MP0003186_abnormal_redox_activity0.81074270
74MP0002064_seizures0.80588123
75MP0005075_abnormal_melanosome_morpholog0.80543197
76MP0002733_abnormal_thermal_nociception0.80366597
77MP0008058_abnormal_DNA_repair0.79978716
78MP0002184_abnormal_innervation0.79796045
79MP0000566_synostosis0.79746362
80MP0003252_abnormal_bile_duct0.79744128
81MP0009780_abnormal_chondrocyte_physiolo0.79193300
82MP0005386_behavior/neurological_phenoty0.79049240
83MP0004924_abnormal_behavior0.79049240
84MP0005377_hearing/vestibular/ear_phenot0.78920200
85MP0003878_abnormal_ear_physiology0.78920200
86MP0002102_abnormal_ear_morphology0.73197382
87MP0001440_abnormal_grooming_behavior0.72071995
88MP0003136_yellow_coat_color0.71236517
89MP0003329_amyloid_beta_deposits0.69667352
90MP0004134_abnormal_chest_morphology0.68082349
91MP0005646_abnormal_pituitary_gland0.67312269
92MP0005551_abnormal_eye_electrophysiolog0.66683559
93MP0004742_abnormal_vestibular_system0.61110809
94MP0005409_darkened_coat_color0.58520253
95MP0008995_early_reproductive_senescence0.57956729
96MP0002234_abnormal_pharynx_morphology0.57882622
97MP0000569_abnormal_digit_pigmentation0.57744680
98MP0000920_abnormal_myelination0.56352838
99MP0005253_abnormal_eye_physiology0.56166796
100MP0010094_abnormal_chromosome_stability0.54494670
101MP0006276_abnormal_autonomic_nervous0.53162016
102MP0003690_abnormal_glial_cell0.52706054
103MP0002796_impaired_skin_barrier0.52663766
104MP0004270_analgesia0.49399950
105MP0003879_abnormal_hair_cell0.49315219
106MP0001486_abnormal_startle_reflex0.48277087
107MP0003699_abnormal_female_reproductive0.46814771
108MP0002229_neurodegeneration0.46254351
109MP0004036_abnormal_muscle_relaxation0.46122701
110MP0001293_anophthalmia0.45891517
111MP0001346_abnormal_lacrimal_gland0.45886444
112MP0001727_abnormal_embryo_implantation0.45798119
113MP0000778_abnormal_nervous_system0.45263927
114MP0002272_abnormal_nervous_system0.44282957
115MP0000751_myopathy0.44258983
116MP0009250_abnormal_appendicular_skeleto0.44041134
117MP0003634_abnormal_glial_cell0.43549526
118MP0002572_abnormal_emotion/affect_behav0.42983369
119MP0002152_abnormal_brain_morphology0.42224699
120MP0000647_abnormal_sebaceous_gland0.41612421
121MP0003633_abnormal_nervous_system0.41357691
122MP0005423_abnormal_somatic_nervous0.40946198
123MP0005391_vision/eye_phenotype0.39749651
124MP0003861_abnormal_nervous_system0.39580595
125MP0002928_abnormal_bile_duct0.38260726
126MP0001324_abnormal_eye_pigmentation0.37823589
127MP0004381_abnormal_hair_follicle0.36245988
128MP0003115_abnormal_respiratory_system0.35815913
129MP0003631_nervous_system_phenotype0.34980847
130MP0003786_premature_aging0.34902179
131MP0000026_abnormal_inner_ear0.34582875
132MP0005636_abnormal_mineral_homeostasis0.34493862
133MP0000015_abnormal_ear_pigmentation0.34470029
134MP0005645_abnormal_hypothalamus_physiol0.34270522
135MP0002882_abnormal_neuron_morphology0.33152734
136MP0000427_abnormal_hair_cycle0.33035354
137MP0005666_abnormal_adipose_tissue0.32195537
138MP0009745_abnormal_behavioral_response0.31892776
139MP0002063_abnormal_learning/memory/cond0.31545047
140MP0001963_abnormal_hearing_physiology0.31288700
141MP0008569_lethality_at_weaning0.30372491
142MP0000358_abnormal_cell_content/0.29964689
143MP0001119_abnormal_female_reproductive0.29733564
144MP0003948_abnormal_gas_homeostasis0.29635442
145MP0002557_abnormal_social/conspecific_i0.29122630
146MP0004811_abnormal_neuron_physiology0.28845750
147MP0000955_abnormal_spinal_cord0.28638656
148MP0002971_abnormal_brown_adipose0.28559337
149MP0003635_abnormal_synaptic_transmissio0.28486608
150MP0002163_abnormal_gland_morphology0.27411418
151MP0000750_abnormal_muscle_regeneration0.26620042
152MP0005195_abnormal_posterior_eye0.26204016
153MP0002876_abnormal_thyroid_physiology0.26048256
154MP0000432_abnormal_head_morphology0.25701757
155MP0002736_abnormal_nociception_after0.25611383
156MP0009384_cardiac_valve_regurgitation0.25541779
157MP0002752_abnormal_somatic_nervous0.25527218

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.44758876
2Abnormal respiratory motile cilium morphology (HP:0005938)8.82068357
3Abnormal respiratory epithelium morphology (HP:0012253)8.82068357
4Rhinitis (HP:0012384)8.03068289
5Abnormal ciliary motility (HP:0012262)7.88129244
6Chronic bronchitis (HP:0004469)6.90125193
7Infertility (HP:0000789)6.11293513
8Nasal polyposis (HP:0100582)6.01585577
9Abnormality of the nasal mucosa (HP:0000433)4.89470542
10Bronchiectasis (HP:0002110)4.49533021
11Pancreatic cysts (HP:0001737)4.43303317
12Nephronophthisis (HP:0000090)4.36486426
13Bronchitis (HP:0012387)4.15668208
14Chronic hepatic failure (HP:0100626)3.75692871
15Male infertility (HP:0003251)3.42573845
16Abnormality of the renal medulla (HP:0100957)3.41492853
17Abnormality of the lower motor neuron (HP:0002366)3.21724043
18Recurrent sinusitis (HP:0011108)3.16580550
19Recurrent otitis media (HP:0000403)3.11630581
20Type II lissencephaly (HP:0007260)3.03903241
21Medial flaring of the eyebrow (HP:0010747)3.03163229
22Tubulointerstitial nephritis (HP:0001970)2.91841164
23Acute necrotizing encephalopathy (HP:0006965)2.90928280
243-Methylglutaconic aciduria (HP:0003535)2.80198921
25Abnormal spermatogenesis (HP:0008669)2.78739756
26Mitochondrial inheritance (HP:0001427)2.75769291
27Male pseudohermaphroditism (HP:0000037)2.75565265
28Acute encephalopathy (HP:0006846)2.66552442
29Tubular atrophy (HP:0000092)2.65625820
30Abnormality of midbrain morphology (HP:0002418)2.62598186
31Molar tooth sign on MRI (HP:0002419)2.62598186
32Progressive macrocephaly (HP:0004481)2.61392677
33Increased CSF lactate (HP:0002490)2.59518713
34Hepatocellular necrosis (HP:0001404)2.58973320
35Renal cortical cysts (HP:0000803)2.58817154
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.54396856
37Sclerocornea (HP:0000647)2.53428201
38Asplenia (HP:0001746)2.52372302
39Abnormal mitochondria in muscle tissue (HP:0008316)2.46197116
40Tubulointerstitial abnormality (HP:0001969)2.45915133
41Hepatic necrosis (HP:0002605)2.45804960
42Gonadotropin excess (HP:0000837)2.44876882
43Intestinal atresia (HP:0011100)2.41817584
44Attenuation of retinal blood vessels (HP:0007843)2.40398714
45Furrowed tongue (HP:0000221)2.38667775
46Pendular nystagmus (HP:0012043)2.36026871
47Abnormality of the dental root (HP:0006486)2.34522606
48Taurodontia (HP:0000679)2.34522606
49Abnormality of permanent molar morphology (HP:0011071)2.34522606
50Abolished electroretinogram (ERG) (HP:0000550)2.34374098
51Occipital encephalocele (HP:0002085)2.33152587
52Amyotrophic lateral sclerosis (HP:0007354)2.33085718
53Recurrent bronchitis (HP:0002837)2.32696885
54Methylmalonic acidemia (HP:0002912)2.32498656
55Anencephaly (HP:0002323)2.29991029
56Congenital stationary night blindness (HP:0007642)2.28673422
57Abnormality of molar (HP:0011077)2.23811012
58Abnormality of molar morphology (HP:0011070)2.23811012
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.23266626
60Abnormal rod and cone electroretinograms (HP:0008323)2.20193980
61Hyperventilation (HP:0002883)2.17695732
62Fibular hypoplasia (HP:0003038)2.14863063
63Abnormality of the dental pulp (HP:0006479)2.14459866
64Microglossia (HP:0000171)2.14149906
65Impaired proprioception (HP:0010831)2.11202710
66Azoospermia (HP:0000027)2.10881569
67Impulsivity (HP:0100710)2.10798180
68Methylmalonic aciduria (HP:0012120)2.07197494
69Median cleft lip (HP:0000161)2.06660084
70Postaxial foot polydactyly (HP:0001830)2.06260499
71Hypomagnesemia (HP:0002917)2.05963406
72Abnormality of the labia minora (HP:0012880)2.05777097
73Congenital, generalized hypertrichosis (HP:0004540)2.04845802
74Hyperglycinuria (HP:0003108)2.04211308
75Cerebellar dysplasia (HP:0007033)2.03501189
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01876448
77Retinal dysplasia (HP:0007973)2.00068518
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4047467
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.2848657
80Absent/shortened dynein arms (HP:0200106)12.2848657
81Optic nerve hypoplasia (HP:0000609)1.99059666
82Congenital hepatic fibrosis (HP:0002612)1.98623697
83Hyperglycinemia (HP:0002154)1.94947172
84Stage 5 chronic kidney disease (HP:0003774)1.94345371
85Tubulointerstitial fibrosis (HP:0005576)1.93678888
86Absent frontal sinuses (HP:0002688)1.91716052
87Supernumerary spleens (HP:0009799)1.91329703
88Ketoacidosis (HP:0001993)1.90771497
89Colon cancer (HP:0003003)1.89770080
90Short tibia (HP:0005736)1.89237434
91J-shaped sella turcica (HP:0002680)1.88917889
92Progressive cerebellar ataxia (HP:0002073)1.87103408
93Increased serum lactate (HP:0002151)1.86646115
94Preaxial hand polydactyly (HP:0001177)1.86483134
95Oligodactyly (hands) (HP:0001180)1.85726085
96Cerebral edema (HP:0002181)1.84635771
97Abnormal drinking behavior (HP:0030082)1.84578041
98Polydipsia (HP:0001959)1.84578041
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84563888
100Large for gestational age (HP:0001520)1.83887968
101Bony spicule pigmentary retinopathy (HP:0007737)1.82338428
102Abnormality of the pons (HP:0007361)1.82241347
103Chronic sinusitis (HP:0011109)1.81836913
104Polyuria (HP:0000103)1.81354236
105Abnormality of the renal cortex (HP:0011035)1.80725077
106Short ribs (HP:0000773)1.80712129
107Multicystic kidney dysplasia (HP:0000003)1.79384580
108Renal dysplasia (HP:0000110)1.79256974
109Increased hepatocellular lipid droplets (HP:0006565)1.77415685
110Abnormality of glycine metabolism (HP:0010895)1.77007528
111Abnormality of serine family amino acid metabolism (HP:0010894)1.77007528
112Hypothermia (HP:0002045)1.76538819
113Dandy-Walker malformation (HP:0001305)1.76228202
114Hypoplasia of the pons (HP:0012110)1.75974523
115Optic disc pallor (HP:0000543)1.75661790
116Hyperalaninemia (HP:0003348)1.75186702
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75186702
118Abnormality of alanine metabolism (HP:0010916)1.75186702
119Gait imbalance (HP:0002141)1.73105955
120Brushfield spots (HP:0001088)1.72690135
121Lipid accumulation in hepatocytes (HP:0006561)1.70834034
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70257068
123Increased corneal curvature (HP:0100692)1.70147654
124Congenital primary aphakia (HP:0007707)1.69543596
125Oculomotor apraxia (HP:0000657)1.67770268
126Postaxial hand polydactyly (HP:0001162)1.66678097
127Neurofibrillary tangles (HP:0002185)1.64533778
128Abnormality of dentin (HP:0010299)1.63498058
129Pancreatic fibrosis (HP:0100732)1.59694956
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.56669212
131Upper motor neuron abnormality (HP:0002127)1.55019671
132Abnormal gallbladder physiology (HP:0012438)1.54741674
133Cholecystitis (HP:0001082)1.54741674
134Abnormality of renal excretion (HP:0011036)1.54329655
135Spastic tetraparesis (HP:0001285)1.52777068
136Bell-shaped thorax (HP:0001591)1.49132209
137Pachygyria (HP:0001302)1.47372737
138Aplasia/Hypoplasia of the lens (HP:0008063)1.46641485
139Supranuclear gaze palsy (HP:0000605)1.46445184
140Abnormal biliary tract physiology (HP:0012439)1.44416630
141Bile duct proliferation (HP:0001408)1.44416630
142Facial cleft (HP:0002006)1.44179105
143Broad distal phalanx of finger (HP:0009836)1.43981038
144Selective tooth agenesis (HP:0001592)1.43953696
145Nephrogenic diabetes insipidus (HP:0009806)1.41300601
146Heterotopia (HP:0002282)1.40789926
147Dyschromatopsia (HP:0007641)1.40467816
148Genital tract atresia (HP:0001827)1.38916420
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36776440
150Short thorax (HP:0010306)1.36557562
151Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.36517953
152Aplasia involving bones of the extremities (HP:0009825)1.35112643
153Aplasia involving bones of the upper limbs (HP:0009823)1.35112643
154Aplasia of the phalanges of the hand (HP:0009802)1.35112643
155Abnormality of ocular smooth pursuit (HP:0000617)1.35017704
156Vaginal atresia (HP:0000148)1.34887884
157Hypoplasia of dental enamel (HP:0006297)1.33578262
158Deformed sella turcica (HP:0002681)1.33554439
159Cystic liver disease (HP:0006706)1.33185931
160Decreased central vision (HP:0007663)1.33136623
161Poor coordination (HP:0002370)1.32725704
162Aplasia/Hypoplasia of the fibula (HP:0006492)1.32393020
163True hermaphroditism (HP:0010459)1.30843849
164Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29952581
165Absent epiphyses (HP:0010577)1.29952581
166Gaze-evoked nystagmus (HP:0000640)1.29381407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.68017558
2PDK48.68017558
3PDK25.80168566
4FRK4.81212445
5TESK14.62557353
6PRKD33.48267633
7STK393.06613034
8ICK2.72987669
9PTK2B2.68808998
10MST42.65008598
11WNK42.61926085
12PNCK2.57344924
13MAP4K22.51569894
14WNK32.47031405
15ADRBK22.42178323
16NUAK12.28434597
17ACVR1B2.18413848
18ZAK2.01799235
19TRIM281.88329746
20STK161.87082694
21INSRR1.78304018
22CASK1.76441775
23TAOK31.63037842
24MAPK131.57375439
25VRK11.55052100
26VRK21.53130968
27STK381.47558155
28NEK21.40884428
29DYRK21.36374237
30WNK11.30223931
31BCR1.29653112
32CDK191.24418927
33PAK31.21741243
34EIF2AK31.20679661
35MAPK151.19775587
36TLK11.18391759
37ERBB31.16092789
38MKNK21.09560416
39SRPK11.07775613
40TYRO31.01759950
41PLK21.00578119
42NEK60.96445074
43PLK30.94291544
44CSNK1G20.93523435
45PDK10.93417352
46STK30.93009165
47CDC70.92566839
48NME10.91277386
49NTRK30.88323593
50DYRK1B0.86243191
51PHKG10.80249747
52PHKG20.80249747
53CDK120.79801900
54BCKDK0.79506481
55ADRBK10.77919519
56DYRK30.77297614
57PINK10.75653671
58PRKCE0.75163228
59CSNK1G10.71775191
60TXK0.71563855
61CSNK1G30.71358202
62TAF10.71220051
63PIK3CA0.69088465
64MKNK10.67347362
65CAMK1G0.67180513
66TEC0.64191253
67CCNB10.62553289
68MAP2K70.60725259
69IRAK10.57765345
70CSNK1A1L0.56506972
71BUB10.55963257
72TTK0.55407888
73LMTK20.53818035
74MUSK0.53425295
75CHEK20.53208410
76WEE10.51974963
77MAPKAPK50.51523985
78RIPK40.50349602
79ITK0.50194151
80TGFBR10.49955017
81PASK0.49179134
82PRKCG0.48657290
83PDPK10.45278866
84TIE10.44775536
85LIMK10.44648198
86MAP3K120.43206282
87NLK0.43155015
88PIK3CG0.40402186
89BRSK20.39010054
90NTRK20.38586303
91CHEK10.37863768
92STK38L0.37675099
93DAPK20.35269030
94PKN10.34169776
95IRAK20.33482720
96TNK20.33481735
97RPS6KA50.33437749
98MAP3K70.31268643
99FGFR20.29705834
100ATM0.29420364
101BRAF0.28968487
102CSNK1A10.28962939
103CAMKK20.28727863
104CSNK1E0.27356140
105MAP3K40.26709358
106PAK10.25608136
107CAMKK10.25294209
108OXSR10.25071543
109TESK20.24653353
110YES10.23251945
111CAMK2A0.22718317
112ATR0.22711676
113EPHA40.22206975
114PLK40.21668236
115PAK60.20649071
116CDK30.19512837
117PRKAA10.19452402
118STK110.18344563
119PAK20.17101958
120MAPK70.14828959
121TNIK0.14456821
122MARK10.14288432
123MINK10.14240374
124PRKCQ0.14212535
125PRKG10.13875635
126MTOR0.13400704
127FES0.13015562
128CSNK1D0.11946439
129MAPK120.11917753
130RPS6KB10.11802955
131PDGFRB0.11450071
132CDK60.11126427
133GSK3B0.10911442
134PLK10.09932199
135MAPK100.09700746
136MARK20.09637628
137PRKDC0.09481711
138BMPR1B0.09110773
139BMX0.08722172
140PRKACB0.07848417
141MAPK80.07708404
142FER0.06981221
143CDK50.06616691
144CAMK10.05884921
145OBSCN0.05406076
146CDK10.04889870
147CDK150.04882563
148PRKCB0.04404589
149MAP2K60.04330309
150MARK30.04221417
151PRKACA0.04182502
152GRK10.03333669
153CSNK2A10.03297994
154PRKACG0.03269940
155BRSK10.02622709
156EPHB10.02009114
157PRKCA0.02005288

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.43672693
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.78176850
3Pyruvate metabolism_Homo sapiens_hsa006203.77985105
4Protein export_Homo sapiens_hsa030603.24172009
5Oxidative phosphorylation_Homo sapiens_hsa001903.21812818
6Propanoate metabolism_Homo sapiens_hsa006403.12680059
7Basal transcription factors_Homo sapiens_hsa030223.11906869
8Linoleic acid metabolism_Homo sapiens_hsa005912.95869838
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.93715931
10Dorso-ventral axis formation_Homo sapiens_hsa043202.90271533
11Fatty acid biosynthesis_Homo sapiens_hsa000612.89715300
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80971821
13Phototransduction_Homo sapiens_hsa047442.77317090
14Glucagon signaling pathway_Homo sapiens_hsa049222.67260282
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.64647049
16Parkinsons disease_Homo sapiens_hsa050122.58878039
17RNA polymerase_Homo sapiens_hsa030202.26681913
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.24675884
19Pentose phosphate pathway_Homo sapiens_hsa000302.24232295
20Butanoate metabolism_Homo sapiens_hsa006502.21881720
21Fanconi anemia pathway_Homo sapiens_hsa034602.11806846
22Huntingtons disease_Homo sapiens_hsa050162.11723006
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99552915
24Selenocompound metabolism_Homo sapiens_hsa004501.97865644
25Homologous recombination_Homo sapiens_hsa034401.92955919
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91033251
27Amphetamine addiction_Homo sapiens_hsa050311.89900690
28Ether lipid metabolism_Homo sapiens_hsa005651.89151436
29Glycerolipid metabolism_Homo sapiens_hsa005611.83216956
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82579744
31Cardiac muscle contraction_Homo sapiens_hsa042601.80230484
32Oocyte meiosis_Homo sapiens_hsa041141.74916572
33Proteasome_Homo sapiens_hsa030501.74350694
34Renin secretion_Homo sapiens_hsa049241.65384537
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63465407
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61966770
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58729598
38RNA degradation_Homo sapiens_hsa030181.56255041
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55054176
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.53642232
41Ribosome_Homo sapiens_hsa030101.49761643
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.49243009
43Tryptophan metabolism_Homo sapiens_hsa003801.48397145
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45158812
45Nitrogen metabolism_Homo sapiens_hsa009101.44640456
46Peroxisome_Homo sapiens_hsa041461.43112599
47Caffeine metabolism_Homo sapiens_hsa002321.41275200
48Long-term potentiation_Homo sapiens_hsa047201.32311333
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31528175
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30701216
51Mineral absorption_Homo sapiens_hsa049781.30308697
52Sphingolipid metabolism_Homo sapiens_hsa006001.24842261
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23541044
54PPAR signaling pathway_Homo sapiens_hsa033201.22780823
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.22185544
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19483361
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18638138
58One carbon pool by folate_Homo sapiens_hsa006701.17699048
59Regulation of autophagy_Homo sapiens_hsa041401.15702527
60Mismatch repair_Homo sapiens_hsa034301.11505281
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.11097355
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10467830
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.09835123
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05438061
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03022821
66beta-Alanine metabolism_Homo sapiens_hsa004101.02013409
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98509846
68Nucleotide excision repair_Homo sapiens_hsa034200.95145631
69Carbon metabolism_Homo sapiens_hsa012000.94761343
70mRNA surveillance pathway_Homo sapiens_hsa030150.93501715
71Arachidonic acid metabolism_Homo sapiens_hsa005900.93076169
72Calcium signaling pathway_Homo sapiens_hsa040200.91890207
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89923292
74Fat digestion and absorption_Homo sapiens_hsa049750.87225289
75Fatty acid elongation_Homo sapiens_hsa000620.86258217
76Pyrimidine metabolism_Homo sapiens_hsa002400.84382280
77Non-homologous end-joining_Homo sapiens_hsa034500.84366733
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83037447
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81864156
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78758469
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78564324
82Purine metabolism_Homo sapiens_hsa002300.77423582
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77073724
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76732145
85Insulin secretion_Homo sapiens_hsa049110.76266966
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75185862
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74888918
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74027639
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73507762
90Fructose and mannose metabolism_Homo sapiens_hsa000510.72759784
91Taste transduction_Homo sapiens_hsa047420.72237696
92ABC transporters_Homo sapiens_hsa020100.71676311
93Salivary secretion_Homo sapiens_hsa049700.71182364
94Estrogen signaling pathway_Homo sapiens_hsa049150.69701303
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69542098
96Folate biosynthesis_Homo sapiens_hsa007900.69535115
97Glutamatergic synapse_Homo sapiens_hsa047240.67899220
98Antigen processing and presentation_Homo sapiens_hsa046120.65744027
99Fatty acid metabolism_Homo sapiens_hsa012120.65556169
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63295439
101Serotonergic synapse_Homo sapiens_hsa047260.62200247
102Gastric acid secretion_Homo sapiens_hsa049710.61354241
103Circadian entrainment_Homo sapiens_hsa047130.59372949
104Biosynthesis of amino acids_Homo sapiens_hsa012300.59166535
105VEGF signaling pathway_Homo sapiens_hsa043700.58117657
106Base excision repair_Homo sapiens_hsa034100.57003233
107Steroid biosynthesis_Homo sapiens_hsa001000.56807962
108Pancreatic secretion_Homo sapiens_hsa049720.56300696
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55780922
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54630315
111Fatty acid degradation_Homo sapiens_hsa000710.53963314
112Inositol phosphate metabolism_Homo sapiens_hsa005620.53826657
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.53295820
114Chemical carcinogenesis_Homo sapiens_hsa052040.53190033
115GABAergic synapse_Homo sapiens_hsa047270.52999141
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49582342
117Nicotine addiction_Homo sapiens_hsa050330.48139079
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47802855
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.46609295
120Glutathione metabolism_Homo sapiens_hsa004800.46411921
121Collecting duct acid secretion_Homo sapiens_hsa049660.46113228
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45635779
123Sulfur relay system_Homo sapiens_hsa041220.45420751
124Hedgehog signaling pathway_Homo sapiens_hsa043400.45174304
125Circadian rhythm_Homo sapiens_hsa047100.44051707
126Metabolic pathways_Homo sapiens_hsa011000.43907784
127cAMP signaling pathway_Homo sapiens_hsa040240.43829426
128Histidine metabolism_Homo sapiens_hsa003400.43037455
129RNA transport_Homo sapiens_hsa030130.42237330
130Oxytocin signaling pathway_Homo sapiens_hsa049210.41439454
131Endocytosis_Homo sapiens_hsa041440.40784794
132Bile secretion_Homo sapiens_hsa049760.39433533
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39271705
134Axon guidance_Homo sapiens_hsa043600.39216331
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37712821
136Basal cell carcinoma_Homo sapiens_hsa052170.37540538
137Renin-angiotensin system_Homo sapiens_hsa046140.37170257
138Systemic lupus erythematosus_Homo sapiens_hsa053220.37102426
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.36688246
140Spliceosome_Homo sapiens_hsa030400.35200707
141Alzheimers disease_Homo sapiens_hsa050100.34578760
142Olfactory transduction_Homo sapiens_hsa047400.32543042
143Ovarian steroidogenesis_Homo sapiens_hsa049130.32397625
144Sulfur metabolism_Homo sapiens_hsa009200.32326863
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.31425353
146Synaptic vesicle cycle_Homo sapiens_hsa047210.31243529
147Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31146643
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31003254
149Lysine degradation_Homo sapiens_hsa003100.30640923
150AMPK signaling pathway_Homo sapiens_hsa041520.30106651
151Cocaine addiction_Homo sapiens_hsa050300.29621945
152Thyroid hormone synthesis_Homo sapiens_hsa049180.28893272
153Type I diabetes mellitus_Homo sapiens_hsa049400.28838784
154Wnt signaling pathway_Homo sapiens_hsa043100.25235054
155Morphine addiction_Homo sapiens_hsa050320.19775296
156B cell receptor signaling pathway_Homo sapiens_hsa046620.18439970
157Dopaminergic synapse_Homo sapiens_hsa047280.17984065
158Retinol metabolism_Homo sapiens_hsa008300.17508555
159Alcoholism_Homo sapiens_hsa050340.16421168
160Vitamin digestion and absorption_Homo sapiens_hsa049770.14305166

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