FAM228A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.67140935
2cell wall macromolecule metabolic process (GO:0044036)9.67140935
3multicellular organism reproduction (GO:0032504)9.25121242
4sperm motility (GO:0030317)8.76910714
5acrosome reaction (GO:0007340)8.28845869
6plasma membrane fusion (GO:0045026)8.17573676
7sperm-egg recognition (GO:0035036)7.92524562
8regulation of meiosis I (GO:0060631)7.82899270
9regulation of female gonad development (GO:2000194)7.67895835
10regulation of DNA methylation (GO:0044030)7.59611726
11piRNA metabolic process (GO:0034587)7.51534272
12axonemal dynein complex assembly (GO:0070286)7.48295527
13reproduction (GO:0000003)7.33122087
14epithelial cilium movement (GO:0003351)7.27596856
15motile cilium assembly (GO:0044458)7.10224238
16male meiosis (GO:0007140)7.08414857
17cell-cell recognition (GO:0009988)7.04684639
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.76939134
19regulation of acrosome reaction (GO:0060046)6.75773161
20binding of sperm to zona pellucida (GO:0007339)6.51086781
21cilium movement (GO:0003341)6.41980709
22regulation of histone H3-K9 methylation (GO:0051570)6.33717146
23spermatid development (GO:0007286)6.12624530
24oocyte development (GO:0048599)5.85005386
25gene silencing by RNA (GO:0031047)5.81459280
26retinal cone cell development (GO:0046549)5.69479703
27female gamete generation (GO:0007292)5.67009902
28single fertilization (GO:0007338)5.56806701
29regulation of cilium movement (GO:0003352)5.53222263
30positive regulation of histone H3-K4 methylation (GO:0051571)5.42001537
31synaptonemal complex organization (GO:0070193)5.36633633
32negative regulation of reproductive process (GO:2000242)5.18963382
33DNA methylation involved in gamete generation (GO:0043046)5.16107156
34central nervous system myelination (GO:0022010)5.16063141
35axon ensheathment in central nervous system (GO:0032291)5.16063141
36sperm capacitation (GO:0048240)5.14768498
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03786183
38DNA alkylation (GO:0006305)5.02057966
39DNA methylation (GO:0006306)5.02057966
40synaptonemal complex assembly (GO:0007130)4.96570796
41ventricular system development (GO:0021591)4.91381234
42negative regulation of inclusion body assembly (GO:0090084)4.79814684
43male meiosis I (GO:0007141)4.72107953
44fertilization (GO:0009566)4.68954543
45positive regulation of gastrulation (GO:2000543)4.46708029
46meiotic cell cycle process (GO:1903046)4.46446847
47positive regulation of meiosis (GO:0045836)4.45124651
48histone H3-K9 demethylation (GO:0033169)4.43134905
49spermatid nucleus differentiation (GO:0007289)4.34621068
50glycine transport (GO:0015816)4.28293854
51regulation of meiosis (GO:0040020)4.21490806
52protein kinase C signaling (GO:0070528)4.21020379
53positive regulation of meiotic cell cycle (GO:0051446)4.16459744
54regulation of steroid hormone secretion (GO:2000831)4.13512418
55negative regulation of histone methylation (GO:0031061)4.10573188
56chromosome organization involved in meiosis (GO:0070192)4.01507843
57cell recognition (GO:0008037)3.96998791
58calcium ion-dependent exocytosis (GO:0017156)3.96671465
59spermatogenesis (GO:0007283)3.96665999
60male gamete generation (GO:0048232)3.94911395
61phosphorelay signal transduction system (GO:0000160)3.93081727
62organic cation transport (GO:0015695)3.92655706
63regulation of meiotic cell cycle (GO:0051445)3.82980267
64regulation of cell maturation (GO:1903429)3.81559039
65gene silencing (GO:0016458)3.77434320
66cellular process involved in reproduction in multicellular organism (GO:0022412)3.76465643
67microtubule depolymerization (GO:0007019)3.72711130
68regulation of inclusion body assembly (GO:0090083)3.70830922
69gamete generation (GO:0007276)3.68499886
70L-amino acid import (GO:0043092)3.66765988
71axoneme assembly (GO:0035082)3.66535250
72positive regulation of histone methylation (GO:0031062)3.66455656
73regulation of female receptivity (GO:0045924)3.66371430
74DNA methylation or demethylation (GO:0044728)3.66144490
75phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.64432143
76meiotic nuclear division (GO:0007126)3.62969360
77oogenesis (GO:0048477)3.58352541
78protein polyglutamylation (GO:0018095)3.56431478
79negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.55058720
80germ cell development (GO:0007281)3.52340963
81mitotic chromosome condensation (GO:0007076)3.49991030
82positive regulation of humoral immune response (GO:0002922)3.45287372
83meiosis I (GO:0007127)3.43499828
84positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.42529914
85base-excision repair, AP site formation (GO:0006285)3.41004189
86positive regulation of cellular amide metabolic process (GO:0034250)3.39653265
87interkinetic nuclear migration (GO:0022027)3.34894703
88intraciliary transport (GO:0042073)3.32757061
89sister chromatid cohesion (GO:0007062)3.30795816
90primitive streak formation (GO:0090009)3.30023243
91microtubule severing (GO:0051013)3.28914051
92synapsis (GO:0007129)3.26749698
93cilium morphogenesis (GO:0060271)3.25028523
94pyrimidine-containing compound transmembrane transport (GO:0072531)3.24551748
95regulation of microtubule-based movement (GO:0060632)3.24381901
96regulation of histone H3-K4 methylation (GO:0051569)3.21741258
97amino acid import (GO:0043090)3.19331047
98DNA modification (GO:0006304)3.19145197
99monoubiquitinated protein deubiquitination (GO:0035520)3.14260371
100female mating behavior (GO:0060180)3.13028972
101attachment of spindle microtubules to kinetochore (GO:0008608)3.11867366
102left/right pattern formation (GO:0060972)3.10307614
103positive regulation of reproductive process (GO:2000243)3.06426456
104resolution of meiotic recombination intermediates (GO:0000712)3.06089321
105regulation of retinoic acid receptor signaling pathway (GO:0048385)3.05289686
106somite rostral/caudal axis specification (GO:0032525)3.04767924
107substrate-independent telencephalic tangential migration (GO:0021826)3.04228586
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.04228586
109regulation of steroid hormone biosynthetic process (GO:0090030)3.02644664
110regulation of histone methylation (GO:0031060)3.02494556
111auditory behavior (GO:0031223)3.02478034
112cilium organization (GO:0044782)3.01565370
113positive regulation of catecholamine secretion (GO:0033605)3.00839581
114cilium assembly (GO:0042384)3.00596813
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00452978
116protein localization to chromosome (GO:0034502)3.00027977
117positive regulation of mitotic sister chromatid separation (GO:1901970)2.97558995
118positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97558995
119positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97558995
120protein localization to cilium (GO:0061512)2.97015470
121regulation of chromatin silencing (GO:0031935)2.96107109
122N-terminal protein amino acid acetylation (GO:0006474)2.96082228
123mitotic metaphase plate congression (GO:0007080)2.95423277
124meiotic chromosome segregation (GO:0045132)2.93480728
125positive regulation of uterine smooth muscle contraction (GO:0070474)2.93422519
126negative regulation of gene silencing (GO:0060969)2.90339814
127pyrimidine dimer repair (GO:0006290)2.89782625
128regulation of reproductive process (GO:2000241)2.89768859
129multicellular organismal reproductive process (GO:0048609)2.83961292
130fatty acid elongation (GO:0030497)2.83357043
131cellular component assembly involved in morphogenesis (GO:0010927)2.82575396
132mechanosensory behavior (GO:0007638)2.82496813
133metaphase plate congression (GO:0051310)2.77753669
134establishment of protein localization to Golgi (GO:0072600)2.77402788
135negative regulation of astrocyte differentiation (GO:0048712)2.77357067
136regulation of calcium ion-dependent exocytosis (GO:0017158)2.76709597
137protein targeting to Golgi (GO:0000042)2.75271633
138establishment of chromosome localization (GO:0051303)2.74932132
139negative regulation of hormone biosynthetic process (GO:0032353)2.72966382
140cellular response to pH (GO:0071467)2.72666708
141citrulline biosynthetic process (GO:0019240)2.72319624
142relaxation of smooth muscle (GO:0044557)2.70525159
143regulation of inositol phosphate biosynthetic process (GO:0010919)2.70234648
144negative regulation of execution phase of apoptosis (GO:1900118)2.69932788
145lactate metabolic process (GO:0006089)2.69500201
146centriole assembly (GO:0098534)2.68906244
147DNA replication-dependent nucleosome organization (GO:0034723)2.67526558
148DNA replication-dependent nucleosome assembly (GO:0006335)2.67526558
149microtubule polymerization or depolymerization (GO:0031109)2.67088706
150presynaptic membrane assembly (GO:0097105)2.66160952
151negative regulation of neurotransmitter secretion (GO:0046929)2.64421352
152activated T cell proliferation (GO:0050798)2.62478318
153regulation of pigment cell differentiation (GO:0050932)2.62061506
154negative regulation of neurotransmitter transport (GO:0051589)2.61715092
155nonmotile primary cilium assembly (GO:0035058)2.60281880
156centriole replication (GO:0007099)2.59634668
157presynaptic membrane organization (GO:0097090)2.54658435
158microtubule-based movement (GO:0007018)2.49752905
159retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49417175
160C4-dicarboxylate transport (GO:0015740)2.47528049
161cerebral cortex radially oriented cell migration (GO:0021799)2.45425595
162protein K11-linked deubiquitination (GO:0035871)2.44798747
163response to auditory stimulus (GO:0010996)2.44503511
164meiotic cell cycle (GO:0051321)2.44000815
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43824309
166fat-soluble vitamin biosynthetic process (GO:0042362)2.42898574
167glycerol ether metabolic process (GO:0006662)2.42771500
168cyclic nucleotide catabolic process (GO:0009214)2.41531768
169calcium ion import (GO:0070509)2.37247222
170preassembly of GPI anchor in ER membrane (GO:0016254)2.36192512
171cAMP catabolic process (GO:0006198)2.35009431
172regulation of response to osmotic stress (GO:0047484)2.34532509
173response to methylmercury (GO:0051597)2.33452529
174multicellular organismal development (GO:0007275)2.25278475
175cilium or flagellum-dependent cell motility (GO:0001539)11.6970592
176fusion of sperm to egg plasma membrane (GO:0007342)10.7504077
177acrosome assembly (GO:0001675)10.4371779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.48683301
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.32593384
3EZH2_22144423_ChIP-Seq_EOC_Human4.00109333
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.88263022
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.11581087
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82659344
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74198466
8GBX2_23144817_ChIP-Seq_PC3_Human2.57472860
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37314217
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35642495
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34081276
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28568567
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.25449638
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22138904
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22138904
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22138904
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18633735
18VDR_22108803_ChIP-Seq_LS180_Human2.18199047
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.14240436
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96169305
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91531232
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89459110
23TAF15_26573619_Chip-Seq_HEK293_Human1.82261690
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.77687724
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75751269
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.75268475
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.67578900
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67205297
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.66545001
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61750868
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59611509
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.58306240
33RNF2_27304074_Chip-Seq_NSC_Mouse1.57450625
34CMYC_18555785_Chip-Seq_ESCs_Mouse1.56486635
35EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56350503
36P53_22387025_ChIP-Seq_ESCs_Mouse1.55207726
37REST_21632747_ChIP-Seq_MESCs_Mouse1.54646128
38OCT4_18555785_Chip-Seq_ESCs_Mouse1.54585266
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54286767
40P300_18555785_Chip-Seq_ESCs_Mouse1.53698596
41STAT3_18555785_Chip-Seq_ESCs_Mouse1.51116818
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50745802
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50660902
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.50525246
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47941563
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.47742423
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46897418
48AR_25329375_ChIP-Seq_VCAP_Human1.44174016
49KDM2B_26808549_Chip-Seq_REH_Human1.43630236
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43333588
51ER_23166858_ChIP-Seq_MCF-7_Human1.43126228
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43048322
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.42110039
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41533794
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.41013286
56KLF4_18555785_Chip-Seq_ESCs_Mouse1.39111575
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.38717050
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37821645
59FUS_26573619_Chip-Seq_HEK293_Human1.37480113
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36457057
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36079216
62RUNX2_22187159_ChIP-Seq_PCA_Human1.35957273
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35273738
64PU1_27457419_Chip-Seq_LIVER_Mouse1.34372970
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34287271
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.33202485
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32796596
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32767582
69SMAD4_21799915_ChIP-Seq_A2780_Human1.32448163
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32018430
71STAT3_23295773_ChIP-Seq_U87_Human1.31233762
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31082215
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30544794
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30170120
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29911316
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.29675022
77SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29186978
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.28872105
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28485785
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26688802
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26415961
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.25251990
83TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25078205
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24919602
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24818472
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.24772671
87BCAT_22108803_ChIP-Seq_LS180_Human1.23313944
88ZFX_18555785_Chip-Seq_ESCs_Mouse1.22934453
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.21727598
90TCF4_23295773_ChIP-Seq_U87_Human1.20348206
91CTCF_18555785_Chip-Seq_ESCs_Mouse1.19873604
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19733960
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.19716268
94P300_19829295_ChIP-Seq_ESCs_Human1.18133513
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17970520
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17481368
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.16427452
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16422306
99IGF1R_20145208_ChIP-Seq_DFB_Human1.15910002
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15683995
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15656354
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15274649
103CBP_20019798_ChIP-Seq_JUKART_Human1.15274649
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14954031
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13012844
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.11296572
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.10937129
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09072293
109EWS_26573619_Chip-Seq_HEK293_Human1.09032257
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08516040
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08032168
112STAT1_17558387_ChIP-Seq_HELA_Human1.07629872
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07371685
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.06980543
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05967175
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05825289
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.05310706
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04875888
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04636275
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04581407
121ZNF274_21170338_ChIP-Seq_K562_Hela1.04473140
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03974782
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03974782
124GF1_26923725_Chip-Seq_HPCs_Mouse1.02584136
125TP53_22573176_ChIP-Seq_HFKS_Human0.99606767
126IRF1_19129219_ChIP-ChIP_H3396_Human0.99287792
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98722082
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96115211
129FOXH1_21741376_ChIP-Seq_EPCs_Human0.94435541
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92201001
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91290976
132NANOG_20526341_ChIP-Seq_ESCs_Human0.90960285
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.90073358
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88455054
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88367020
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87842568
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87308823
138HTT_18923047_ChIP-ChIP_STHdh_Human0.85969237
139TCF4_22108803_ChIP-Seq_LS180_Human0.85360046
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85174553
141RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84441374
142KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82657829
143FOXM1_23109430_ChIP-Seq_U2OS_Human0.81683233
144CBP_21632823_ChIP-Seq_H3396_Human0.80148232
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.79202590
146TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78503703
147BP1_19119308_ChIP-ChIP_Hs578T_Human0.77970630
148TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77729627
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77432618
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75887215
151FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.75684115
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74717700
153KLF4_19829295_ChIP-Seq_ESCs_Human0.74259006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.06785576
2MP0008789_abnormal_olfactory_epithelium4.01540445
3MP0003698_abnormal_male_reproductive3.87863048
4MP0005394_taste/olfaction_phenotype3.66341174
5MP0005499_abnormal_olfactory_system3.66341174
6MP0001929_abnormal_gametogenesis3.24806547
7MP0008877_abnormal_DNA_methylation3.13156139
8MP0005409_darkened_coat_color2.75429879
9MP0003890_abnormal_embryonic-extraembry2.67268821
10MP0003136_yellow_coat_color2.53786114
11MP0003950_abnormal_plasma_membrane2.45783704
12MP0009046_muscle_twitch2.40020355
13MP0001486_abnormal_startle_reflex2.34636746
14MP0005623_abnormal_meninges_morphology2.30847902
15MP0003879_abnormal_hair_cell2.29573769
16MP0003693_abnormal_embryo_hatching2.26638636
17MP0000566_synostosis2.26155525
18MP0005395_other_phenotype2.20463753
19MP0008058_abnormal_DNA_repair2.16841389
20MP0003699_abnormal_female_reproductive2.15550023
21MP0002210_abnormal_sex_determination2.15380414
22MP0003690_abnormal_glial_cell2.03562545
23MP0005410_abnormal_fertilization10.2196096
24MP0005171_absent_coat_pigmentation1.97875970
25MP0002161_abnormal_fertility/fecundity1.87906433
26MP0001986_abnormal_taste_sensitivity1.87527433
27MP0001145_abnormal_male_reproductive1.77184690
28MP0005167_abnormal_blood-brain_barrier1.74366977
29MP0003880_abnormal_central_pattern1.73916296
30MP0005551_abnormal_eye_electrophysiolog1.72869451
31MP0006292_abnormal_olfactory_placode1.72554171
32MP0003121_genomic_imprinting1.72477540
33MP0001984_abnormal_olfaction1.68674499
34MP0010030_abnormal_orbit_morphology1.66317957
35MP0002638_abnormal_pupillary_reflex1.65826703
36MP0006276_abnormal_autonomic_nervous1.63839494
37MP0004381_abnormal_hair_follicle1.62346354
38MP0002234_abnormal_pharynx_morphology1.60992075
39MP0000920_abnormal_myelination1.60900106
40MP0000653_abnormal_sex_gland1.57821230
41MP0002139_abnormal_hepatobiliary_system1.53760410
42MP0002653_abnormal_ependyma_morphology1.46514857
43MP0001119_abnormal_female_reproductive1.45461631
44MP0003329_amyloid_beta_deposits1.43375624
45MP0000372_irregular_coat_pigmentation1.39749849
46MP0004885_abnormal_endolymph1.36964916
47MP0009745_abnormal_behavioral_response1.34088749
48MP0001188_hyperpigmentation1.33939490
49MP0003633_abnormal_nervous_system1.32846521
50MP0003635_abnormal_synaptic_transmissio1.32002226
51MP0002233_abnormal_nose_morphology1.31427027
52MP0010368_abnormal_lymphatic_system1.31406042
53MP0002272_abnormal_nervous_system1.31345722
54MP0001293_anophthalmia1.30062557
55MP0004043_abnormal_pH_regulation1.29523096
56MP0009780_abnormal_chondrocyte_physiolo1.27934836
57MP0000647_abnormal_sebaceous_gland1.27345165
58MP0009384_cardiac_valve_regurgitation1.23049544
59MP0003631_nervous_system_phenotype1.22336295
60MP0002138_abnormal_hepatobiliary_system1.21910330
61MP0004270_analgesia1.21140624
62MP0005360_urolithiasis1.20951557
63MP0002064_seizures1.20716061
64MP0002572_abnormal_emotion/affect_behav1.19658925
65MP0003119_abnormal_digestive_system1.19228438
66MP0001502_abnormal_circadian_rhythm1.18568323
67MP0005253_abnormal_eye_physiology1.15243458
68MP0000049_abnormal_middle_ear1.13806406
69MP0008995_early_reproductive_senescence1.12259172
70MP0008569_lethality_at_weaning1.11266081
71MP0001485_abnormal_pinna_reflex1.10896291
72MP0005647_abnormal_sex_gland1.08772937
73MP0000383_abnormal_hair_follicle1.07924962
74MP0005377_hearing/vestibular/ear_phenot1.07311217
75MP0003878_abnormal_ear_physiology1.07311217
76MP0009379_abnormal_foot_pigmentation1.04407448
77MP0002102_abnormal_ear_morphology1.04376634
78MP0002160_abnormal_reproductive_system1.04359911
79MP0005451_abnormal_body_composition1.03966054
80MP0001963_abnormal_hearing_physiology1.03835606
81MP0003077_abnormal_cell_cycle1.03076624
82MP0005646_abnormal_pituitary_gland1.02620702
83MP0003634_abnormal_glial_cell1.02084137
84MP0002557_abnormal_social/conspecific_i0.99561439
85MP0004019_abnormal_vitamin_homeostasis0.99034020
86MP0004859_abnormal_synaptic_plasticity0.98198179
87MP0005379_endocrine/exocrine_gland_phen0.97215445
88MP0005174_abnormal_tail_pigmentation0.96631984
89MP0002063_abnormal_learning/memory/cond0.96558284
90MP0003632_abnormal_nervous_system0.95097380
91MP0002734_abnormal_mechanical_nocicepti0.95076986
92MP0010234_abnormal_vibrissa_follicle0.93977546
93MP0000015_abnormal_ear_pigmentation0.93931738
94MP0003252_abnormal_bile_duct0.93402030
95MP0000778_abnormal_nervous_system0.92692171
96MP0002938_white_spotting0.92425524
97MP0001905_abnormal_dopamine_level0.91645294
98MP0002229_neurodegeneration0.89542524
99MP0001440_abnormal_grooming_behavior0.89304388
100MP0005423_abnormal_somatic_nervous0.89166500
101MP0010094_abnormal_chromosome_stability0.88292704
102MP0003183_abnormal_peptide_metabolism0.85498482
103MP0001730_embryonic_growth_arrest0.85394608
104MP0000026_abnormal_inner_ear0.84557064
105MP0003011_delayed_dark_adaptation0.83965914
106MP0002067_abnormal_sensory_capabilities0.82605014
107MP0001529_abnormal_vocalization0.80292259
108MP0002735_abnormal_chemical_nociception0.79515041
109MP0004742_abnormal_vestibular_system0.78707996
110MP0005645_abnormal_hypothalamus_physiol0.77947744
111MP0003111_abnormal_nucleus_morphology0.76244783
112MP0001664_abnormal_digestion0.75861278
113MP0005389_reproductive_system_phenotype0.75632282
114MP0005195_abnormal_posterior_eye0.74166633
115MP0006138_congestive_heart_failure0.74015793
116MP0000427_abnormal_hair_cycle0.73689875
117MP0001968_abnormal_touch/_nociception0.73176022
118MP0004811_abnormal_neuron_physiology0.72277416
119MP0005187_abnormal_penis_morphology0.72229764
120MP0002752_abnormal_somatic_nervous0.71824535
121MP0003861_abnormal_nervous_system0.70398456
122MP0006072_abnormal_retinal_apoptosis0.70174006
123MP0002736_abnormal_nociception_after0.69846910
124MP0004142_abnormal_muscle_tone0.67747038
125MP0000678_abnormal_parathyroid_gland0.67614883
126MP0002751_abnormal_autonomic_nervous0.66322352
127MP0001177_atelectasis0.65571271
128MP0002882_abnormal_neuron_morphology0.65195523
129MP0001324_abnormal_eye_pigmentation0.63412271
130MP0005083_abnormal_biliary_tract0.63321045
131MP0008932_abnormal_embryonic_tissue0.62695244
132MP0005670_abnormal_white_adipose0.62168300
133MP0003279_aneurysm0.62153163
134MP0000631_abnormal_neuroendocrine_gland0.60682445
135MP0000579_abnormal_nail_morphology0.59963170
136MP0002127_abnormal_cardiovascular_syste0.59638625
137MP0002066_abnormal_motor_capabilities/c0.59152965
138MP0000762_abnormal_tongue_morphology0.58349863
139MP0010678_abnormal_skin_adnexa0.57347843
140MP0000955_abnormal_spinal_cord0.57244472
141MP0008057_abnormal_DNA_replication0.57219737
142MP0004134_abnormal_chest_morphology0.56878680
143MP0002254_reproductive_system_inflammat0.56761145
144MP0003935_abnormal_craniofacial_develop0.56118542
145MP0009840_abnormal_foam_cell0.55976480
146MP0001970_abnormal_pain_threshold0.55805881
147MP0002084_abnormal_developmental_patter0.55257231
148MP0004924_abnormal_behavior0.54878787
149MP0005386_behavior/neurological_phenoty0.54878787
150MP0001501_abnormal_sleep_pattern0.54782139
151MP0002152_abnormal_brain_morphology0.54197763

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.99056178
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.99056178
3Abnormal respiratory motile cilium physiology (HP:0012261)7.15146224
4Abnormal respiratory motile cilium morphology (HP:0005938)6.79876921
5Abnormal respiratory epithelium morphology (HP:0012253)6.79876921
6Abnormal ciliary motility (HP:0012262)6.29879997
7Rhinitis (HP:0012384)5.82868277
8Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.41936139
9Papillary thyroid carcinoma (HP:0002895)4.74977115
10Abdominal situs inversus (HP:0003363)4.59863833
11Abnormality of abdominal situs (HP:0011620)4.59863833
12Anterior segment dysgenesis (HP:0007700)4.55320348
13Osteomalacia (HP:0002749)4.34726733
14Chronic bronchitis (HP:0004469)4.19528065
15Facial hemangioma (HP:0000329)4.15468606
16Infertility (HP:0000789)4.01106251
17Oligodactyly (hands) (HP:0001180)3.96059266
18Nephronophthisis (HP:0000090)3.94334057
19Impulsivity (HP:0100710)3.80097356
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.52596511
21Hypoplasia of the fovea (HP:0007750)3.52596511
22Medial flaring of the eyebrow (HP:0010747)3.49636181
23Lip pit (HP:0100267)3.45793296
24Neurofibrillary tangles (HP:0002185)3.37485694
25Nasal polyposis (HP:0100582)3.25586407
26Abnormality of the renal medulla (HP:0100957)3.23493363
27Short tibia (HP:0005736)3.22426626
28Apathy (HP:0000741)3.18459665
29Tubulointerstitial nephritis (HP:0001970)3.18247712
30Myokymia (HP:0002411)3.15721888
31Bronchiectasis (HP:0002110)3.14052734
32Abnormality of the labia minora (HP:0012880)2.97465492
33Hypophosphatemic rickets (HP:0004912)2.97329045
34Hemiparesis (HP:0001269)2.95772022
35Diminished motivation (HP:0000745)2.94464209
36Abnormality of the fovea (HP:0000493)2.94285800
37Premature ovarian failure (HP:0008209)2.94042438
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.89683656
39Molar tooth sign on MRI (HP:0002419)2.86801632
40Abnormality of midbrain morphology (HP:0002418)2.86801632
41Oligodactyly (HP:0012165)2.72928502
42Truncal obesity (HP:0001956)2.72215981
43Pancreatic fibrosis (HP:0100732)2.65414699
44Abnormality of the nasal mucosa (HP:0000433)2.61636094
45Recurrent sinusitis (HP:0011108)2.60859697
46Supernumerary spleens (HP:0009799)2.60614747
47Gait imbalance (HP:0002141)2.59047830
48Thyroid carcinoma (HP:0002890)2.58548506
49Wrist flexion contracture (HP:0001239)2.53145449
50Postaxial foot polydactyly (HP:0001830)2.52001774
51Sensory axonal neuropathy (HP:0003390)2.50976287
52Congenital primary aphakia (HP:0007707)2.49621063
53Abnormality of the renal cortex (HP:0011035)2.49130890
54Malnutrition (HP:0004395)2.44572511
55Bronchitis (HP:0012387)2.44110144
56Congenital hepatic fibrosis (HP:0002612)2.41906415
57True hermaphroditism (HP:0010459)2.41350351
58Maternal diabetes (HP:0009800)2.40187485
59Optic nerve hypoplasia (HP:0000609)2.37417880
60Generalized aminoaciduria (HP:0002909)2.35609171
61Dysdiadochokinesis (HP:0002075)2.28034680
62Aplasia involving bones of the upper limbs (HP:0009823)2.26531112
63Aplasia of the phalanges of the hand (HP:0009802)2.26531112
64Aplasia involving bones of the extremities (HP:0009825)2.26531112
65Abnormal drinking behavior (HP:0030082)2.24785129
66Polydipsia (HP:0001959)2.24785129
67Renal cortical cysts (HP:0000803)2.23774230
68Chronic hepatic failure (HP:0100626)2.21914496
69Nephrogenic diabetes insipidus (HP:0009806)2.20647265
70Esotropia (HP:0000565)2.18832087
71Cerebral inclusion bodies (HP:0100314)2.18664454
72Abnormal gallbladder physiology (HP:0012438)2.17763409
73Cholecystitis (HP:0001082)2.17763409
74Capillary hemangiomas (HP:0005306)2.16973919
75Abnormal lung lobation (HP:0002101)2.15515110
76Parakeratosis (HP:0001036)2.13120823
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.12117705
78Recurrent otitis media (HP:0000403)2.11641493
79Polyphagia (HP:0002591)2.10295346
80Type II lissencephaly (HP:0007260)2.10085214
81Abnormal spermatogenesis (HP:0008669)2.08838079
82Hypercortisolism (HP:0001578)2.08129720
83Hyperventilation (HP:0002883)2.07668723
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07283886
85Increased circulating renin level (HP:0000848)2.06618538
86Chromsome breakage (HP:0040012)2.06517138
87Hypokinesia (HP:0002375)2.05938594
88Genital tract atresia (HP:0001827)2.04927015
89Tubulointerstitial abnormality (HP:0001969)2.04105880
90Vaginal atresia (HP:0000148)2.02178928
91Cone-rod dystrophy (HP:0000548)2.01498309
92Horizontal nystagmus (HP:0000666)2.00591834
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.5454028
94Aplasia/Hypoplasia of the macula (HP:0008059)1.99888509
95Decreased central vision (HP:0007663)1.99493952
96Proximal tubulopathy (HP:0000114)1.98625593
97Hypergonadotropic hypogonadism (HP:0000815)1.97963657
98Abnormality of molar morphology (HP:0011070)1.97312763
99Abnormality of molar (HP:0011077)1.97312763
100Abnormality of the dental root (HP:0006486)1.96884034
101Taurodontia (HP:0000679)1.96884034
102Abnormality of permanent molar morphology (HP:0011071)1.96884034
103Septo-optic dysplasia (HP:0100842)1.95447795
104Complete atrioventricular canal defect (HP:0001674)1.94778783
105Microglossia (HP:0000171)1.94180137
106Clumsiness (HP:0002312)1.94148263
107Postaxial hand polydactyly (HP:0001162)1.93745833
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93303301
109Bundle branch block (HP:0011710)1.93060761
110Azoospermia (HP:0000027)1.92732776
111Aplasia of the musculature (HP:0100854)1.91741671
112Atrioventricular canal defect (HP:0006695)1.90715133
113Conjunctival telangiectasia (HP:0000524)1.90533160
114Stage 5 chronic kidney disease (HP:0003774)1.89808959
115Poor coordination (HP:0002370)1.89554693
116Abnormality of the dental pulp (HP:0006479)1.88534606
117Abnormality of the anterior chamber (HP:0000593)1.87215680
118Occipital encephalocele (HP:0002085)1.87178044
119Absent septum pellucidum (HP:0001331)1.87020594
120Fair hair (HP:0002286)1.86706165
121Enlarged penis (HP:0000040)1.85687603
122Widely patent fontanelles and sutures (HP:0004492)1.84911735
123White forelock (HP:0002211)1.84129327
124Hypoplastic pelvis (HP:0008839)1.84017298
125Renal dysplasia (HP:0000110)1.83532185
126Abnormality of the phalanges of the hallux (HP:0010057)1.83058302
127Aplasia/Hypoplasia of the lens (HP:0008063)1.82804554
128Nephropathy (HP:0000112)1.82291430
129Skin pits (HP:0100276)1.82291329
130Median cleft lip (HP:0000161)1.81338819
131Bicornuate uterus (HP:0000813)1.81121000
132Prolonged neonatal jaundice (HP:0006579)1.80806522
133Aplasia/Hypoplasia affecting the retina (HP:0008061)1.80798164
134Patchy hypopigmentation of hair (HP:0011365)1.80493455
135Lissencephaly (HP:0001339)1.79668176
136Abnormal eating behavior (HP:0100738)1.79454012
137Pancreatic cysts (HP:0001737)1.78752531
138J-shaped sella turcica (HP:0002680)1.78568453
139Heterotopia (HP:0002282)1.77442675
140Congenital sensorineural hearing impairment (HP:0008527)1.76741723
141Retinal dysplasia (HP:0007973)1.75980725
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74806559
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.74806559
144Methylmalonic acidemia (HP:0002912)1.73597748
145Muscle stiffness (HP:0003552)1.73283977
146Abnormality of renal excretion (HP:0011036)1.72514077
147Non-midline cleft lip (HP:0100335)1.72287605
148Peripheral hypomyelination (HP:0007182)1.72160036
149Supranuclear gaze palsy (HP:0000605)1.72080739
150Pachygyria (HP:0001302)1.71132527
151Bell-shaped thorax (HP:0001591)1.70849024
152Gaze-evoked nystagmus (HP:0000640)1.70544731
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70086632
154Volvulus (HP:0002580)1.69074065
155Atonic seizures (HP:0010819)1.68718795
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68576451
157Tubular atrophy (HP:0000092)1.68111771
158Hypoplastic left heart (HP:0004383)1.66614775
159Hypomagnesemia (HP:0002917)1.65894864
160Metabolic alkalosis (HP:0200114)1.62501004
161Abnormal biliary tract physiology (HP:0012439)1.60816907
162Bile duct proliferation (HP:0001408)1.60816907
163Abnormal urine output (HP:0012590)1.60787116
164Abnormality of the septum pellucidum (HP:0007375)1.60220399
165Abnormality of saccadic eye movements (HP:0000570)1.59673400
166Slow saccadic eye movements (HP:0000514)1.57261566
167Gonadotropin excess (HP:0000837)1.56339856
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.55081723
169Preaxial hand polydactyly (HP:0001177)1.53292558
170Male infertility (HP:0003251)1.52165657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.75200898
2MAP3K95.47937342
3ARAF4.97072180
4PDK44.81699705
5PDK34.81699705
6STK393.54034119
7PDK23.46319830
8TAOK32.98177150
9CASK2.90013049
10MET2.81042946
11BRAF2.42593853
12STK242.37484989
13BLK2.23941587
14WNK42.23002050
15TNIK2.16940163
16MUSK2.12900056
17PNCK2.12836172
18MOS1.95403690
19ICK1.87120111
20AURKA1.86401997
21PTK2B1.83551120
22EPHA41.83294243
23TESK21.82773372
24OXSR11.77144729
25GRK11.77058956
26CAMK1G1.70471559
27CDK91.66821559
28RAF11.66600626
29MAP3K41.64003209
30TRIM281.62057753
31TESK11.54396180
32PRKCI1.53102033
33CLK11.51820860
34NEK61.49823988
35KSR21.48432939
36CDK121.47837388
37IRAK11.45663709
38PRKD31.41177417
39KSR11.39886732
40RIPK41.37116720
41WNK11.31636760
42MAPKAPK51.31338432
43PLK11.26893397
44PKN11.16865121
45GRK71.13162289
46NTRK21.09375341
47CSNK1G11.08032029
48CAMK1D1.03790582
49BMX1.03342329
50PHKG21.02947267
51PHKG11.02947267
52CDK71.02554799
53IRAK30.97662403
54ZAK0.92521578
55STK380.92314636
56MAPK150.91815738
57TEC0.89294136
58NLK0.88137358
59CDK190.87275281
60IRAK20.87079539
61FGR0.84751742
62PTK20.84456424
63NUAK10.83310060
64NTRK30.83272710
65BMPR20.81132180
66YES10.80939469
67MELK0.80755914
68CDC70.79873896
69CHEK10.78623773
70ATR0.77052705
71NEK20.76148425
72MARK30.75363487
73CSNK1E0.74643085
74CSF1R0.73816670
75CDK30.73506501
76ACVR1B0.73237293
77CSNK1G30.72873603
78SGK2230.71851353
79SGK4940.71851353
80ATM0.71076640
81INSRR0.68513875
82PDK10.68440318
83CSNK1G20.68341324
84MARK20.68217736
85PRKCE0.68072727
86CAMK2A0.66090645
87PIK3CA0.65598000
88PRKCZ0.65495219
89MAPK130.65383237
90MAP2K20.65383113
91EPHB10.65064387
92BMPR1B0.63893802
93MAP3K130.62968763
94BRSK10.62686540
95PINK10.62430574
96EIF2AK20.62087701
97MAP2K70.61411351
98PIM10.61154068
99CDK20.60448513
100PRKCG0.60232299
101PAK10.58408396
102TNK20.57757368
103GRK50.56284522
104BUB10.55346677
105PRPF4B0.54118925
106CSNK1A1L0.53760307
107MAP3K140.53196536
108NEK90.52008838
109TYRO30.51667762
110ADRBK20.50106386
111PLK40.49115678
112MAP3K20.49075207
113PRKG10.47534467
114VRK10.46419835
115MINK10.46138531
116CDK10.45994566
117TXK0.45634107
118MAPK40.45311387
119PDPK10.44962353
120MAPK120.44925792
121CDK50.43666787
122MKNK20.43558275
123WNK30.41670813
124UHMK10.41487879
125MAP3K50.41382601
126CCNB10.41023502
127PRKACB0.40674788
128CAMK2B0.40067550
129PRKCQ0.39976990
130SRPK10.39826687
131MTOR0.39474611
132STK30.38865465
133PRKACA0.38707857
134STK38L0.38202133
135CAMK10.38011006
136CDK11A0.37729955
137MAPK70.37677612
138IRAK40.37654525
139GSK3B0.37186975
140CAMK40.36529274
141DYRK1A0.36250002
142CDK80.34258577
143TLK10.32954742
144MARK10.32772310
145MAPK100.32589203
146SGK20.32448422
147PBK0.31430899
148PLK20.30889717
149LMTK20.29852262
150FYN0.29585835
151CAMK2D0.28810582
152TTK0.28661186
153FES0.28098441
154PLK30.27236023
155PRKAA10.26656859
156AKT20.26646396
157DYRK20.25481594
158CAMK2G0.24531611
159ABL10.22675869
160STK110.22098727
161PAK30.22006534
162CSNK1D0.20889397
163HIPK20.20011766
164DYRK1B0.19551353

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.58168299
2Oocyte meiosis_Homo sapiens_hsa041143.28930241
3Cell cycle_Homo sapiens_hsa041103.08011861
4Ether lipid metabolism_Homo sapiens_hsa005652.98435316
5Steroid biosynthesis_Homo sapiens_hsa001002.93817365
6Fatty acid elongation_Homo sapiens_hsa000622.86254191
7Base excision repair_Homo sapiens_hsa034102.66218607
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62956198
9Propanoate metabolism_Homo sapiens_hsa006402.58545764
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48848649
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.45041851
12Linoleic acid metabolism_Homo sapiens_hsa005912.41603592
13Mismatch repair_Homo sapiens_hsa034302.31648014
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.23703186
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.13985441
16Vitamin B6 metabolism_Homo sapiens_hsa007502.06129761
17Nicotine addiction_Homo sapiens_hsa050332.04087393
18RNA degradation_Homo sapiens_hsa030181.99512859
19Dorso-ventral axis formation_Homo sapiens_hsa043201.94837449
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.89774957
21Glutamatergic synapse_Homo sapiens_hsa047241.88644094
22Morphine addiction_Homo sapiens_hsa050321.84753411
23Caffeine metabolism_Homo sapiens_hsa002321.80338955
24Gap junction_Homo sapiens_hsa045401.79042638
25Sphingolipid metabolism_Homo sapiens_hsa006001.74699772
26mRNA surveillance pathway_Homo sapiens_hsa030151.68794087
27Fanconi anemia pathway_Homo sapiens_hsa034601.65676572
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65212844
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.64868112
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60214832
31Salivary secretion_Homo sapiens_hsa049701.55436023
32Renin secretion_Homo sapiens_hsa049241.53266474
33Glycerolipid metabolism_Homo sapiens_hsa005611.43863992
34RNA transport_Homo sapiens_hsa030131.41213403
35Mineral absorption_Homo sapiens_hsa049781.39099764
36Fatty acid metabolism_Homo sapiens_hsa012121.39000232
37p53 signaling pathway_Homo sapiens_hsa041151.38928072
38Circadian entrainment_Homo sapiens_hsa047131.37569740
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36833275
40Nucleotide excision repair_Homo sapiens_hsa034201.34579329
41PPAR signaling pathway_Homo sapiens_hsa033201.34278669
42GABAergic synapse_Homo sapiens_hsa047271.33175019
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31352510
44Insulin secretion_Homo sapiens_hsa049111.28850931
45Regulation of autophagy_Homo sapiens_hsa041401.28062616
46Arachidonic acid metabolism_Homo sapiens_hsa005901.25761442
47Calcium signaling pathway_Homo sapiens_hsa040201.22997209
48ABC transporters_Homo sapiens_hsa020101.22797670
49Basal transcription factors_Homo sapiens_hsa030221.22401714
50Amphetamine addiction_Homo sapiens_hsa050311.21815848
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17111537
52Vitamin digestion and absorption_Homo sapiens_hsa049771.16937405
53Rheumatoid arthritis_Homo sapiens_hsa053231.16030734
54Pyruvate metabolism_Homo sapiens_hsa006201.12843720
55Glucagon signaling pathway_Homo sapiens_hsa049221.10398605
56TGF-beta signaling pathway_Homo sapiens_hsa043501.09035875
57Gastric acid secretion_Homo sapiens_hsa049711.07568384
58Pancreatic secretion_Homo sapiens_hsa049721.06650572
59Bile secretion_Homo sapiens_hsa049761.05610633
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04072820
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02115254
62Olfactory transduction_Homo sapiens_hsa047401.01202423
63Taste transduction_Homo sapiens_hsa047420.99347625
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99140021
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.98498773
66cAMP signaling pathway_Homo sapiens_hsa040240.96917937
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95852731
68Ovarian steroidogenesis_Homo sapiens_hsa049130.95628817
69Huntingtons disease_Homo sapiens_hsa050160.94353499
70Dopaminergic synapse_Homo sapiens_hsa047280.93917027
71Serotonergic synapse_Homo sapiens_hsa047260.92846486
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89358182
73Renin-angiotensin system_Homo sapiens_hsa046140.88379416
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87148215
75Cocaine addiction_Homo sapiens_hsa050300.84666787
76Pentose phosphate pathway_Homo sapiens_hsa000300.84395058
77DNA replication_Homo sapiens_hsa030300.83324504
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82099159
79Sulfur metabolism_Homo sapiens_hsa009200.80176204
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80084534
81Long-term potentiation_Homo sapiens_hsa047200.79062557
82Phototransduction_Homo sapiens_hsa047440.78844142
83Cardiac muscle contraction_Homo sapiens_hsa042600.75522896
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72655138
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71205513
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69348213
87Inositol phosphate metabolism_Homo sapiens_hsa005620.69256572
88Homologous recombination_Homo sapiens_hsa034400.67764991
89Hedgehog signaling pathway_Homo sapiens_hsa043400.67599361
90Peroxisome_Homo sapiens_hsa041460.66943937
91Synaptic vesicle cycle_Homo sapiens_hsa047210.66733235
92Collecting duct acid secretion_Homo sapiens_hsa049660.66369451
93Fatty acid degradation_Homo sapiens_hsa000710.64560359
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64156823
95Oxytocin signaling pathway_Homo sapiens_hsa049210.63893270
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60083026
97Hippo signaling pathway_Homo sapiens_hsa043900.58781737
98Folate biosynthesis_Homo sapiens_hsa007900.58370974
99Axon guidance_Homo sapiens_hsa043600.58240351
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57612334
101Ras signaling pathway_Homo sapiens_hsa040140.56927521
102Phagosome_Homo sapiens_hsa041450.55277896
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55206926
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.53262639
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53015656
106Wnt signaling pathway_Homo sapiens_hsa043100.52530818
107mTOR signaling pathway_Homo sapiens_hsa041500.51781018
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51636469
109Retinol metabolism_Homo sapiens_hsa008300.49720677
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48782699
111Melanogenesis_Homo sapiens_hsa049160.47377742
112Cholinergic synapse_Homo sapiens_hsa047250.46251144
113Vibrio cholerae infection_Homo sapiens_hsa051100.45160603
114Nitrogen metabolism_Homo sapiens_hsa009100.45046394
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44180663
116Metabolic pathways_Homo sapiens_hsa011000.43732622
117Selenocompound metabolism_Homo sapiens_hsa004500.43366437
118Long-term depression_Homo sapiens_hsa047300.43308586
119Histidine metabolism_Homo sapiens_hsa003400.43115877
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.42878053
121Purine metabolism_Homo sapiens_hsa002300.42284327
122Circadian rhythm_Homo sapiens_hsa047100.40955445
123Choline metabolism in cancer_Homo sapiens_hsa052310.40273760
124ErbB signaling pathway_Homo sapiens_hsa040120.39427592
125Thyroid hormone synthesis_Homo sapiens_hsa049180.38122130
126Alzheimers disease_Homo sapiens_hsa050100.37749258
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37611279
128Adherens junction_Homo sapiens_hsa045200.36223176
129African trypanosomiasis_Homo sapiens_hsa051430.35311647
130RNA polymerase_Homo sapiens_hsa030200.33945224
131Butanoate metabolism_Homo sapiens_hsa006500.33905296
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.33528731
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.33163839
134Arginine and proline metabolism_Homo sapiens_hsa003300.32881261
135AMPK signaling pathway_Homo sapiens_hsa041520.32495041
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32255215
137Endocytosis_Homo sapiens_hsa041440.32031587
138Basal cell carcinoma_Homo sapiens_hsa052170.31890023
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31723059
140Estrogen signaling pathway_Homo sapiens_hsa049150.30445978
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27366532
142FoxO signaling pathway_Homo sapiens_hsa040680.26766758
143MAPK signaling pathway_Homo sapiens_hsa040100.26092802
144Tight junction_Homo sapiens_hsa045300.25113680
145Endometrial cancer_Homo sapiens_hsa052130.24479587
146Rap1 signaling pathway_Homo sapiens_hsa040150.23170738
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19511100
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17858291

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