FAM228B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)6.04530129
2L-amino acid import (GO:0043092)5.84904483
3presynaptic membrane assembly (GO:0097105)5.22921518
4amino acid import (GO:0043090)5.14350689
5fatty acid elongation (GO:0030497)4.88571460
6myelination (GO:0042552)4.59970207
7axon ensheathment (GO:0008366)4.52969751
8ensheathment of neurons (GO:0007272)4.52969751
9tryptophan catabolic process (GO:0006569)4.49386652
10indole-containing compound catabolic process (GO:0042436)4.49386652
11indolalkylamine catabolic process (GO:0046218)4.49386652
12indolalkylamine metabolic process (GO:0006586)4.47642967
13oligodendrocyte differentiation (GO:0048709)4.42274707
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.39563302
15C4-dicarboxylate transport (GO:0015740)4.38370006
16cilium or flagellum-dependent cell motility (GO:0001539)4.32832858
17kynurenine metabolic process (GO:0070189)4.21939192
18establishment of mitochondrion localization (GO:0051654)4.19337902
19negative regulation of cytosolic calcium ion concentration (GO:0051481)4.15122653
20behavioral response to nicotine (GO:0035095)4.08805130
21positive regulation of developmental pigmentation (GO:0048087)4.06041377
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.92378586
23neurotransmitter uptake (GO:0001504)3.85108768
24detection of light stimulus involved in visual perception (GO:0050908)3.83579069
25detection of light stimulus involved in sensory perception (GO:0050962)3.83579069
26response to dietary excess (GO:0002021)3.82852431
27tryptophan metabolic process (GO:0006568)3.82627885
28glycerophospholipid catabolic process (GO:0046475)3.79129131
29glutamate receptor signaling pathway (GO:0007215)3.78070577
30establishment of protein localization to Golgi (GO:0072600)3.77377429
31signal peptide processing (GO:0006465)3.74917625
32purine ribonucleotide transport (GO:0015868)3.65943137
33purine nucleotide transport (GO:0015865)3.65335404
34monoubiquitinated protein deubiquitination (GO:0035520)3.56650560
35L-fucose catabolic process (GO:0042355)3.56553124
36fucose catabolic process (GO:0019317)3.56553124
37L-fucose metabolic process (GO:0042354)3.56553124
38interkinetic nuclear migration (GO:0022027)3.55977019
39gamma-aminobutyric acid transport (GO:0015812)3.55334515
40neural tube formation (GO:0001841)3.54725822
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54510335
42photoreceptor cell differentiation (GO:0046530)3.54327094
43eye photoreceptor cell differentiation (GO:0001754)3.54327094
44cerebral cortex radially oriented cell migration (GO:0021799)3.52781926
45negative regulation of protein localization to cell surface (GO:2000009)3.52678344
46synaptic transmission, glutamatergic (GO:0035249)3.51456190
47motile cilium assembly (GO:0044458)3.51352210
48long-chain fatty acid biosynthetic process (GO:0042759)3.51027952
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47149382
50adenine nucleotide transport (GO:0051503)3.43601335
51snRNA transcription (GO:0009301)3.41108407
52regulation of hippo signaling (GO:0035330)3.40603311
53neuron cell-cell adhesion (GO:0007158)3.40086340
54negative regulation of translation, ncRNA-mediated (GO:0040033)3.38601086
55regulation of translation, ncRNA-mediated (GO:0045974)3.38601086
56negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38601086
57behavioral response to ethanol (GO:0048149)3.34877873
58limb bud formation (GO:0060174)3.34750143
59indole-containing compound metabolic process (GO:0042430)3.32417384
60protein K11-linked deubiquitination (GO:0035871)3.29605880
61oxidative demethylation (GO:0070989)3.27076844
62protein K48-linked deubiquitination (GO:0071108)3.26241058
63cholesterol biosynthetic process (GO:0006695)3.25138004
64regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23109839
65photoreceptor cell maintenance (GO:0045494)3.23042405
66acrosome reaction (GO:0007340)3.21822536
67cerebellar granule cell differentiation (GO:0021707)3.20364392
68negative regulation of neurotransmitter transport (GO:0051589)3.18924008
69import into cell (GO:0098657)3.14098916
70regulation of inclusion body assembly (GO:0090083)3.13368911
71transmission of nerve impulse (GO:0019226)3.11568106
72myelin maintenance (GO:0043217)3.08770544
73membrane depolarization during action potential (GO:0086010)3.07824915
74negative regulation of astrocyte differentiation (GO:0048712)3.07158200
75reflex (GO:0060004)3.05700403
76cellular ketone body metabolic process (GO:0046950)3.05149252
77serotonin metabolic process (GO:0042428)3.03739226
78auditory behavior (GO:0031223)3.01979334
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00982626
80regulation of gene silencing by RNA (GO:0060966)3.00739729
81regulation of posttranscriptional gene silencing (GO:0060147)3.00739729
82regulation of gene silencing by miRNA (GO:0060964)3.00739729
83neuronal action potential (GO:0019228)2.99666187
84NAD biosynthetic process (GO:0009435)2.98024987
85negative regulation of macroautophagy (GO:0016242)2.96754123
86neuron-neuron synaptic transmission (GO:0007270)2.96378334
87L-serine metabolic process (GO:0006563)2.94414872
88magnesium ion transport (GO:0015693)2.94050723
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93962270
90primary amino compound metabolic process (GO:1901160)2.92474385
91response to lipoprotein particle (GO:0055094)2.91962454
92nucleotide transport (GO:0006862)2.91241171
93acidic amino acid transport (GO:0015800)2.91154782
94regulation of sarcomere organization (GO:0060297)2.90895479
95negative regulation of systemic arterial blood pressure (GO:0003085)2.90752360
96thyroid hormone metabolic process (GO:0042403)2.90712202
97cellular biogenic amine catabolic process (GO:0042402)2.90348104
98amine catabolic process (GO:0009310)2.90348104
99axoneme assembly (GO:0035082)2.89322817
100adult walking behavior (GO:0007628)2.89305227
101retinal cone cell development (GO:0046549)2.87848137
102cellular potassium ion homeostasis (GO:0030007)2.86465190
103phospholipid translocation (GO:0045332)2.84889883
104lipid translocation (GO:0034204)2.84889883
105cilium movement (GO:0003341)2.84868524
106response to pheromone (GO:0019236)2.84371468
107negative regulation of inclusion body assembly (GO:0090084)2.84039791
108astrocyte development (GO:0014002)2.83982940
109response to auditory stimulus (GO:0010996)2.82062860
110mannosylation (GO:0097502)2.81209998
111regulation of establishment of cell polarity (GO:2000114)2.78739438
112response to methylmercury (GO:0051597)2.78282459
113positive regulation of synapse assembly (GO:0051965)2.78013957
114mechanosensory behavior (GO:0007638)2.76285562
115regulation of pigment cell differentiation (GO:0050932)2.76038280
116neuronal ion channel clustering (GO:0045161)2.75737244
117sulfation (GO:0051923)2.75372494
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75064766
119membrane tubulation (GO:0097320)2.74774071
120GPI anchor metabolic process (GO:0006505)2.74743213
121regulation of collateral sprouting (GO:0048670)2.74526921
122tachykinin receptor signaling pathway (GO:0007217)2.74032866
123neuron recognition (GO:0008038)2.72049009
124ketone body metabolic process (GO:1902224)2.71018997
125nucleotide transmembrane transport (GO:1901679)2.70894194
126sterol biosynthetic process (GO:0016126)2.70875994
127cilium morphogenesis (GO:0060271)2.70264247
128negative regulation of sodium ion transport (GO:0010766)2.67984158
129cellular response to sterol (GO:0036315)2.67749510
130epithelial cilium movement (GO:0003351)2.67514525
131positive regulation of oligodendrocyte differentiation (GO:0048714)2.66224773
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65392862
133benzene-containing compound metabolic process (GO:0042537)2.64772536
134apical protein localization (GO:0045176)2.64743973
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64022085
136mitochondrion transport along microtubule (GO:0047497)2.64022085
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.63968625
138cilium organization (GO:0044782)2.63757366
139positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.63439364
140negative regulation of mast cell activation (GO:0033004)2.61516844
141aggressive behavior (GO:0002118)2.61462710
142protein K63-linked deubiquitination (GO:0070536)2.61360758
143negative regulation of smoothened signaling pathway (GO:0045879)2.60696587
144asymmetric protein localization (GO:0008105)2.60316021
145cilium assembly (GO:0042384)2.59334309
146protein polyglutamylation (GO:0018095)2.58792479
147histone H3-K9 methylation (GO:0051567)2.58457558
148histone H3-K4 trimethylation (GO:0080182)2.57797063
149cAMP catabolic process (GO:0006198)2.57677825
150positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.57141305
151GPI anchor biosynthetic process (GO:0006506)2.54956463
152atrial cardiac muscle cell action potential (GO:0086014)2.54371354
153negative regulation of neurotransmitter secretion (GO:0046929)2.53807624
154startle response (GO:0001964)2.53462824
155positive regulation of cellular amine metabolic process (GO:0033240)2.52274689
156regulation of establishment or maintenance of cell polarity (GO:0032878)2.51819897
157negative regulation of cAMP-mediated signaling (GO:0043951)2.51779742
158drug catabolic process (GO:0042737)2.51490368
159axon development (GO:0061564)2.50814979
160protein targeting to Golgi (GO:0000042)2.50627064
161behavioral fear response (GO:0001662)2.50456120
162behavioral defense response (GO:0002209)2.50456120
163regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50181196
164sperm motility (GO:0030317)2.49718174
165dendrite morphogenesis (GO:0048813)2.49685381
166neuronal action potential propagation (GO:0019227)2.47935189
167protein localization to synapse (GO:0035418)2.47773874
168glial cell development (GO:0021782)2.47769629
169auditory receptor cell stereocilium organization (GO:0060088)2.47269065
170low-density lipoprotein particle remodeling (GO:0034374)2.47144473
171L-glutamate transport (GO:0015813)2.45566230
172regulation of astrocyte differentiation (GO:0048710)2.45373430
173flavonoid metabolic process (GO:0009812)2.44818940
174cyclic nucleotide catabolic process (GO:0009214)2.44645298
175appendage development (GO:0048736)2.44474194
176limb development (GO:0060173)2.44474194
177regulation of synaptic transmission, glutamatergic (GO:0051966)2.44188257
178cellular response to ATP (GO:0071318)2.43492788
179piRNA metabolic process (GO:0034587)2.43239613
180retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43179617
181negative regulation of synaptic transmission (GO:0050805)2.43167055
182creatine metabolic process (GO:0006600)2.42976647
183cellular response to ethanol (GO:0071361)2.41050548
184aromatic amino acid family catabolic process (GO:0009074)2.40614370
185endosome to melanosome transport (GO:0035646)2.40115684
186endosome to pigment granule transport (GO:0043485)2.40115684
187central nervous system neuron axonogenesis (GO:0021955)2.39332613
188nonmotile primary cilium assembly (GO:0035058)2.39226799
189central nervous system myelination (GO:0022010)10.0866770
190axon ensheathment in central nervous system (GO:0032291)10.0866770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.34162372
2EZH2_22144423_ChIP-Seq_EOC_Human3.61834162
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09788704
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06347728
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64998576
6IGF1R_20145208_ChIP-Seq_DFB_Human2.36234736
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22124993
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13792712
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88475738
10CBX2_27304074_Chip-Seq_ESCs_Mouse1.87701121
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83754607
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.82973122
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81623367
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79015912
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77782692
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76309223
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.75085768
18EWS_26573619_Chip-Seq_HEK293_Human1.74668893
19TAF15_26573619_Chip-Seq_HEK293_Human1.74652303
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72267926
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72267926
22VDR_22108803_ChIP-Seq_LS180_Human1.72259530
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71851382
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70610380
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.69638273
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69004210
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68691474
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68509330
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67529713
30AR_21572438_ChIP-Seq_LNCaP_Human1.67024559
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66960305
32ER_23166858_ChIP-Seq_MCF-7_Human1.66947442
33BCAT_22108803_ChIP-Seq_LS180_Human1.66245789
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.64852390
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64690882
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64611572
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63515119
38REST_21632747_ChIP-Seq_MESCs_Mouse1.63397952
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62468842
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.62240105
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60974248
42TP53_16413492_ChIP-PET_HCT116_Human1.60664393
43CBP_20019798_ChIP-Seq_JUKART_Human1.60482264
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60482264
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.57925185
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57368925
47P300_19829295_ChIP-Seq_ESCs_Human1.55309556
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55218635
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.55192092
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53010308
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52092716
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.49526459
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49340709
54FUS_26573619_Chip-Seq_HEK293_Human1.47644174
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.44598714
56IRF1_19129219_ChIP-ChIP_H3396_Human1.44501232
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.44132394
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42402673
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.41049039
60SMAD4_21799915_ChIP-Seq_A2780_Human1.39642123
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38999840
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38264709
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38079158
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36157197
65TCF4_22108803_ChIP-Seq_LS180_Human1.35990032
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.34824246
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.34132082
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33610652
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33539729
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.33032250
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.31260893
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31078674
73STAT3_23295773_ChIP-Seq_U87_Human1.30853040
74P300_18555785_Chip-Seq_ESCs_Mouse1.29870964
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29516805
76RUNX2_22187159_ChIP-Seq_PCA_Human1.29408077
77P53_22387025_ChIP-Seq_ESCs_Mouse1.29188979
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27082674
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26437335
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.24962929
81AHR_22903824_ChIP-Seq_MCF-7_Human1.24612401
82RNF2_27304074_Chip-Seq_NSC_Mouse1.24378480
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.23860859
84AR_25329375_ChIP-Seq_VCAP_Human1.23737381
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23201552
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22960356
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22845611
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22838010
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22389994
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20587228
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20398663
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.19459898
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19238506
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18239632
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17766112
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.17414358
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.17114021
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17039975
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.16799332
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15856737
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.15626215
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15294397
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15281641
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14986143
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14562425
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.14185374
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13520968
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13520968
109KDM2B_26808549_Chip-Seq_REH_Human1.13152163
110NANOG_19829295_ChIP-Seq_ESCs_Human1.12916319
111SOX2_19829295_ChIP-Seq_ESCs_Human1.12916319
112HTT_18923047_ChIP-ChIP_STHdh_Human1.12038416
113RXR_22108803_ChIP-Seq_LS180_Human1.11691562
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11111090
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10707337
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10414343
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10312854
118PU1_27457419_Chip-Seq_LIVER_Mouse1.10074384
119TP53_22573176_ChIP-Seq_HFKS_Human1.09986946
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.09969241
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09870648
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.09491677
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09152520
124DROSHA_22980978_ChIP-Seq_HELA_Human1.08492614
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06314806
126ZNF274_21170338_ChIP-Seq_K562_Hela1.04784585
127CDX2_22108803_ChIP-Seq_LS180_Human1.04645635
128TCF4_23295773_ChIP-Seq_U87_Human1.04615099
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04280349
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.03920906
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03516888
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03286452
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02844965
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.99792315
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99745576
136AR_19668381_ChIP-Seq_PC3_Human0.99215225
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.98949850
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98855216
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97692627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.92618523
2MP0000569_abnormal_digit_pigmentation4.48447467
3MP0003195_calcinosis3.37565097
4MP0005171_absent_coat_pigmentation3.21655277
5MP0004885_abnormal_endolymph3.06624535
6MP0003880_abnormal_central_pattern3.00838843
7MP0000920_abnormal_myelination2.95748522
8MP0005410_abnormal_fertilization2.91969835
9MP0003646_muscle_fatigue2.91627182
10MP0003950_abnormal_plasma_membrane2.91450387
11MP0004270_analgesia2.89431589
12MP0003690_abnormal_glial_cell2.79980723
13MP0005451_abnormal_body_composition2.64874747
14MP0001486_abnormal_startle_reflex2.64676002
15MP0004859_abnormal_synaptic_plasticity2.61286818
16MP0005409_darkened_coat_color2.54024501
17MP0005670_abnormal_white_adipose2.49244370
18MP0003787_abnormal_imprinting2.46860453
19MP0003635_abnormal_synaptic_transmissio2.17541438
20MP0002272_abnormal_nervous_system2.16497034
21MP0002064_seizures2.10093594
22MP0005423_abnormal_somatic_nervous2.09745705
23MP0001440_abnormal_grooming_behavior2.04674182
24MP0000462_abnormal_digestive_system2.02284758
25MP0009745_abnormal_behavioral_response2.01914552
26MP0001485_abnormal_pinna_reflex1.99141755
27MP0003329_amyloid_beta_deposits1.97198950
28MP0000372_irregular_coat_pigmentation1.94686355
29MP0000778_abnormal_nervous_system1.91009794
30MP0006276_abnormal_autonomic_nervous1.88860269
31MP0000427_abnormal_hair_cycle1.88777998
32MP0006292_abnormal_olfactory_placode1.87888573
33MP0002876_abnormal_thyroid_physiology1.86758703
34MP0002837_dystrophic_cardiac_calcinosis1.82139876
35MP0005646_abnormal_pituitary_gland1.80925492
36MP0002572_abnormal_emotion/affect_behav1.80789323
37MP0003634_abnormal_glial_cell1.75415347
38MP0000566_synostosis1.75368139
39MP0004742_abnormal_vestibular_system1.71713912
40MP0002735_abnormal_chemical_nociception1.70544893
41MP0003045_fibrosis1.67220675
42MP0002938_white_spotting1.66262481
43MP0002063_abnormal_learning/memory/cond1.65667462
44MP0004381_abnormal_hair_follicle1.64766788
45MP0001905_abnormal_dopamine_level1.64716621
46MP0002734_abnormal_mechanical_nocicepti1.62968761
47MP0002736_abnormal_nociception_after1.58524676
48MP0001986_abnormal_taste_sensitivity1.58100183
49MP0001968_abnormal_touch/_nociception1.57879713
50MP0009046_muscle_twitch1.57014696
51MP0005174_abnormal_tail_pigmentation1.56280510
52MP0008872_abnormal_physiological_respon1.52439218
53MP0004142_abnormal_muscle_tone1.52367221
54MP0008961_abnormal_basal_metabolism1.46778080
55MP0001529_abnormal_vocalization1.46317518
56MP0002102_abnormal_ear_morphology1.46198643
57MP0003938_abnormal_ear_development1.43923395
58MP0004130_abnormal_muscle_cell1.40346629
59MP0002557_abnormal_social/conspecific_i1.39814570
60MP0002067_abnormal_sensory_capabilities1.36359558
61MP0008260_abnormal_autophagy1.35397271
62MP0004134_abnormal_chest_morphology1.33852765
63MP0009840_abnormal_foam_cell1.32426243
64MP0001661_extended_life_span1.32219439
65MP0003806_abnormal_nucleotide_metabolis1.31930270
66MP0002653_abnormal_ependyma_morphology1.31792741
67MP0001502_abnormal_circadian_rhythm1.31200141
68MP0001984_abnormal_olfaction1.29848055
69MP0005551_abnormal_eye_electrophysiolog1.27852627
70MP0004147_increased_porphyrin_level1.27620178
71MP0004924_abnormal_behavior1.26748016
72MP0005386_behavior/neurological_phenoty1.26748016
73MP0002638_abnormal_pupillary_reflex1.26586106
74MP0001970_abnormal_pain_threshold1.23316740
75MP0002928_abnormal_bile_duct1.23151308
76MP0010386_abnormal_urinary_bladder1.22630695
77MP0004043_abnormal_pH_regulation1.22465397
78MP0001963_abnormal_hearing_physiology1.20791032
79MP0003937_abnormal_limbs/digits/tail_de1.19748201
80MP0001501_abnormal_sleep_pattern1.19348879
81MP0000955_abnormal_spinal_cord1.18468488
82MP0008569_lethality_at_weaning1.15025877
83MP0003879_abnormal_hair_cell1.13989917
84MP0005167_abnormal_blood-brain_barrier1.13174203
85MP0000647_abnormal_sebaceous_gland1.11808391
86MP0002138_abnormal_hepatobiliary_system1.11436557
87MP0003633_abnormal_nervous_system1.10300147
88MP0000230_abnormal_systemic_arterial1.09993843
89MP0001188_hyperpigmentation1.09563649
90MP0002095_abnormal_skin_pigmentation1.09483635
91MP0002168_other_aberrant_phenotype1.08871267
92MP0003252_abnormal_bile_duct1.07194418
93MP0002733_abnormal_thermal_nociception1.07084017
94MP0002066_abnormal_motor_capabilities/c1.06334031
95MP0003137_abnormal_impulse_conducting1.06034948
96MP0003698_abnormal_male_reproductive1.05574907
97MP0002229_neurodegeneration1.05378945
98MP0004133_heterotaxia1.05332931
99MP0003890_abnormal_embryonic-extraembry1.05112111
100MP0002882_abnormal_neuron_morphology1.00543786
101MP0008877_abnormal_DNA_methylation0.97420379
102MP0003631_nervous_system_phenotype0.96692519
103MP0003632_abnormal_nervous_system0.95318339
104MP0003121_genomic_imprinting0.93500372
105MP0000026_abnormal_inner_ear0.91963215
106MP0005266_abnormal_metabolism0.91489475
107MP0005253_abnormal_eye_physiology0.91420990
108MP0001299_abnormal_eye_distance/0.89815405
109MP0005310_abnormal_salivary_gland0.88783990
110MP0002752_abnormal_somatic_nervous0.87767240
111MP0000015_abnormal_ear_pigmentation0.87722851
112MP0008775_abnormal_heart_ventricle0.86154013
113MP0009780_abnormal_chondrocyte_physiolo0.85576900
114MP0004145_abnormal_muscle_electrophysio0.85570254
115MP0003183_abnormal_peptide_metabolism0.84111716
116MP0002152_abnormal_brain_morphology0.83121047
117MP0002909_abnormal_adrenal_gland0.82084056
118MP0004215_abnormal_myocardial_fiber0.81456506
119MP0002184_abnormal_innervation0.81318163
120MP0001324_abnormal_eye_pigmentation0.78728189
121MP0000604_amyloidosis0.78672700
122MP0000383_abnormal_hair_follicle0.78399348
123MP0004085_abnormal_heartbeat0.77448016
124MP0000538_abnormal_urinary_bladder0.76053327
125MP0005075_abnormal_melanosome_morpholog0.75781713
126MP0005085_abnormal_gallbladder_physiolo0.75040823
127MP0001929_abnormal_gametogenesis0.71676800
128MP0000631_abnormal_neuroendocrine_gland0.67258604
129MP0005645_abnormal_hypothalamus_physiol0.67248946
130MP0006072_abnormal_retinal_apoptosis0.67158794
131MP0009384_cardiac_valve_regurgitation0.66540927
132MP0009697_abnormal_copulation0.66300106
133MP0003718_maternal_effect0.65519152
134MP0008057_abnormal_DNA_replication0.65019809
135MP0005391_vision/eye_phenotype0.64425237
136MP0005195_abnormal_posterior_eye0.63458783
137MP0010678_abnormal_skin_adnexa0.63229971
138MP0005377_hearing/vestibular/ear_phenot0.62020253
139MP0003878_abnormal_ear_physiology0.62020253
140MP0005647_abnormal_sex_gland0.61922319

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.56350516
2Genetic anticipation (HP:0003743)4.53675548
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.16615091
4Absent/shortened dynein arms (HP:0200106)4.16615091
5Parakeratosis (HP:0001036)4.11120945
6Gaze-evoked nystagmus (HP:0000640)4.08334808
7Cerebral inclusion bodies (HP:0100314)3.96408236
8Progressive cerebellar ataxia (HP:0002073)3.86523350
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.75359045
10Protruding tongue (HP:0010808)3.67944338
11Split foot (HP:0001839)3.65077430
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.64053079
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.64053079
14Aplasia involving bones of the upper limbs (HP:0009823)3.56581162
15Aplasia of the phalanges of the hand (HP:0009802)3.56581162
16Aplasia involving bones of the extremities (HP:0009825)3.56581162
17Abnormality of the axillary hair (HP:0100134)3.56230736
18Abnormality of secondary sexual hair (HP:0009888)3.56230736
19Congenital stationary night blindness (HP:0007642)3.52134705
20Abnormality of the renal cortex (HP:0011035)3.40566507
21Abnormality of the renal medulla (HP:0100957)3.32756106
22Clumsiness (HP:0002312)3.28354028
23Hypoplastic pelvis (HP:0008839)3.27712514
24Attenuation of retinal blood vessels (HP:0007843)3.26691008
25Cystic liver disease (HP:0006706)3.23323466
26Medial flaring of the eyebrow (HP:0010747)3.18020712
27Febrile seizures (HP:0002373)3.10104001
28Abnormality of the corticospinal tract (HP:0002492)3.08437832
29Supranuclear gaze palsy (HP:0000605)3.07296172
30Spastic tetraparesis (HP:0001285)3.02497914
31Broad-based gait (HP:0002136)3.01869824
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.98322357
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.93649688
34Humeroradial synostosis (HP:0003041)2.91159198
35Synostosis involving the elbow (HP:0003938)2.91159198
36Abnormal respiratory epithelium morphology (HP:0012253)2.84693043
37Abnormal respiratory motile cilium morphology (HP:0005938)2.84693043
38Tubular atrophy (HP:0000092)2.81440383
39Hyperventilation (HP:0002883)2.79488057
40Occipital encephalocele (HP:0002085)2.78492289
41Fair hair (HP:0002286)2.75097590
42Abnormal respiratory motile cilium physiology (HP:0012261)2.74237644
43Focal seizures (HP:0007359)2.74031930
44Focal motor seizures (HP:0011153)2.72737103
45Gait imbalance (HP:0002141)2.70700742
46Type II lissencephaly (HP:0007260)2.67839748
47Absent speech (HP:0001344)2.67341709
48Follicular hyperkeratosis (HP:0007502)2.66514783
49Thyroid-stimulating hormone excess (HP:0002925)2.65233645
50Bony spicule pigmentary retinopathy (HP:0007737)2.64776453
51Spastic gait (HP:0002064)2.61202962
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.58491241
53Abnormal ciliary motility (HP:0012262)2.58204799
54Congenital primary aphakia (HP:0007707)2.57175265
55Cerebral hypomyelination (HP:0006808)2.55771530
56Abolished electroretinogram (ERG) (HP:0000550)2.53682994
57Hemiparesis (HP:0001269)2.51083462
58Dialeptic seizures (HP:0011146)2.49444519
59Bell-shaped thorax (HP:0001591)2.48797799
60Megalencephaly (HP:0001355)2.43320354
61Absent septum pellucidum (HP:0001331)2.43021393
62Inability to walk (HP:0002540)2.42649104
63Alacrima (HP:0000522)2.41942418
64Long nose (HP:0003189)2.36961980
65Diplopia (HP:0000651)2.36878994
66Abnormality of binocular vision (HP:0011514)2.36878994
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.33657179
68Abnormal drinking behavior (HP:0030082)2.32904410
69Polydipsia (HP:0001959)2.32904410
70Nephrogenic diabetes insipidus (HP:0009806)2.32186988
71Congenital hepatic fibrosis (HP:0002612)2.32120995
72Ankle clonus (HP:0011448)2.31882802
73Cerebellar dysplasia (HP:0007033)2.30884330
74Abnormal biliary tract physiology (HP:0012439)2.30836514
75Bile duct proliferation (HP:0001408)2.30836514
76Decreased circulating renin level (HP:0003351)2.29952565
77Peripheral hypomyelination (HP:0007182)2.29517648
78Morphological abnormality of the inner ear (HP:0011390)2.27594214
79Scanning speech (HP:0002168)2.26840360
80Genital tract atresia (HP:0001827)2.26205118
81Spastic paraparesis (HP:0002313)2.26146483
82Widely spaced teeth (HP:0000687)2.26074398
83Increased corneal curvature (HP:0100692)2.24549638
84Keratoconus (HP:0000563)2.24549638
85Central scotoma (HP:0000603)2.24283796
86Decreased lacrimation (HP:0000633)2.23367447
87Decreased central vision (HP:0007663)2.22686739
88Nephronophthisis (HP:0000090)2.22452323
89Epileptic encephalopathy (HP:0200134)2.22028505
90Generalized hypopigmentation of hair (HP:0011358)2.21483805
91Coronal craniosynostosis (HP:0004440)2.19847981
92Abnormal rod and cone electroretinograms (HP:0008323)2.19770189
93Sclerocornea (HP:0000647)2.19610068
94Furrowed tongue (HP:0000221)2.18745161
95Poor coordination (HP:0002370)2.17337065
96Large for gestational age (HP:0001520)2.17238899
97Vaginal atresia (HP:0000148)2.16787434
983-Methylglutaconic aciduria (HP:0003535)2.16446269
99Confusion (HP:0001289)2.15665028
100Renal cortical cysts (HP:0000803)2.15028782
101Lissencephaly (HP:0001339)2.14954264
102Molar tooth sign on MRI (HP:0002419)2.14163864
103Abnormality of midbrain morphology (HP:0002418)2.14163864
104Pancreatic fibrosis (HP:0100732)2.12413865
105Abnormality of alanine metabolism (HP:0010916)2.10195531
106Hyperalaninemia (HP:0003348)2.10195531
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10195531
108Hyperlipoproteinemia (HP:0010980)2.10062766
109Lower limb muscle weakness (HP:0007340)2.09940789
110Volvulus (HP:0002580)2.09643306
111Dysmetria (HP:0001310)2.09567862
112Congenital sensorineural hearing impairment (HP:0008527)2.09291607
113Onion bulb formation (HP:0003383)2.08921250
114Stomach cancer (HP:0012126)2.08019620
115Blue irides (HP:0000635)2.06628890
116Anencephaly (HP:0002323)2.05543678
117Absence seizures (HP:0002121)2.05333936
118Chronic hepatic failure (HP:0100626)2.05190652
119Hypoplastic left heart (HP:0004383)2.04955241
120Intellectual disability, moderate (HP:0002342)2.02737319
121Patellar aplasia (HP:0006443)2.02629976
122Progressive inability to walk (HP:0002505)2.02229342
123Abnormality of serine family amino acid metabolism (HP:0010894)2.01123144
124Abnormality of glycine metabolism (HP:0010895)2.01123144
125Pheochromocytoma (HP:0002666)1.99452643
126Abnormality of the columella (HP:0009929)1.99037073
127Short foot (HP:0001773)1.98420291
128Postaxial foot polydactyly (HP:0001830)1.98276489
129Intestinal atresia (HP:0011100)1.97311953
130Abnormal auditory evoked potentials (HP:0006958)1.97297723
131True hermaphroditism (HP:0010459)1.96500195
132Atonic seizures (HP:0010819)1.96387291
133Thickened helices (HP:0000391)1.95539131
134Myokymia (HP:0002411)1.94523368
135Hypoplastic ischia (HP:0003175)1.93205543
136Postural instability (HP:0002172)1.92549390
137Duplicated collecting system (HP:0000081)1.90462674
138Mixed hearing impairment (HP:0000410)1.89395311
139Pancreatic cysts (HP:0001737)1.89009228
140Slow saccadic eye movements (HP:0000514)1.88459638
141Septo-optic dysplasia (HP:0100842)1.88349037
142Adrenal hypoplasia (HP:0000835)1.88167688
143Leukodystrophy (HP:0002415)1.86757149
144Paraparesis (HP:0002385)1.86717940
145Alopecia of scalp (HP:0002293)1.85845966
146Abnormality of the septum pellucidum (HP:0007375)1.85068924
147Abnormality of macular pigmentation (HP:0008002)1.84320458
148Male pseudohermaphroditism (HP:0000037)1.84294052
149Aplasia/Hypoplasia of the patella (HP:0006498)1.83876047
150Polyuria (HP:0000103)1.83833889
151Rhinitis (HP:0012384)1.83210482
152Drooling (HP:0002307)1.81842665
153Excessive salivation (HP:0003781)1.81842665
154Abnormality of the ischium (HP:0003174)1.80906518
155Anteriorly placed anus (HP:0001545)1.80753453
156Scotoma (HP:0000575)1.80098354
157Cerebral hemorrhage (HP:0001342)1.79336880
158Tubulointerstitial nephritis (HP:0001970)1.79270265
159Increased cerebral lipofuscin (HP:0011813)1.78105493
160Hypoplastic iliac wings (HP:0002866)1.77853491
161Highly arched eyebrow (HP:0002553)1.77343308
162Hyperglycinuria (HP:0003108)1.76719613
163Preaxial hand polydactyly (HP:0001177)1.76513808
164Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76434348
165Aplasia/hypoplasia of the uterus (HP:0008684)1.76305705
166Dry hair (HP:0011359)1.76031908
167Preaxial foot polydactyly (HP:0001841)1.75503412
168Vascular calcification (HP:0004934)1.75384517
169Retinitis pigmentosa (HP:0000510)1.75327888
170Tented upper lip vermilion (HP:0010804)1.73584131
171Meningocele (HP:0002435)1.71391831
172Aplasia/Hypoplasia of the fovea (HP:0008060)1.70567119
173Hypoplasia of the fovea (HP:0007750)1.70567119
174Abnormality of the middle phalanges of the toes (HP:0010183)1.69892902
175Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69568271
176Retinal dysplasia (HP:0007973)1.69509433
177Abnormality of the dental pulp (HP:0006479)1.69233052
178Sensory axonal neuropathy (HP:0003390)1.69141786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.65673623
2TNIK5.45611837
3MKNK25.32419871
4STK393.42719143
5STK163.08558456
6ACVR1B2.97866878
7MKNK12.88824052
8PNCK2.87701179
9OXSR12.58385599
10CASK2.32411048
11NTRK22.18348409
12TAOK32.04446175
13EPHA42.01507489
14EPHB11.82891350
15MST41.80896385
16GRK11.74964686
17NUAK11.69250713
18AKT31.62102025
19MARK11.59716306
20BMPR1B1.50022013
21PKN11.49725011
22CSNK1A1L1.43556197
23ZAK1.37474809
24ADRBK11.34301626
25MAP4K21.34200454
26CAMK1G1.30570563
27MUSK1.29583966
28CDK191.28661892
29PHKG21.26912564
30PHKG11.26912564
31WNK11.24747502
32NTRK31.24287900
33STK38L1.23922874
34MET1.22221099
35PINK11.21678074
36PRKCG1.21286782
37FGFR41.19861733
38MAPKAPK51.17485513
39CSNK1G31.16142274
40NEK61.15654930
41DAPK21.14059711
42WNK31.13998092
43DYRK21.12328816
44BCR1.10792900
45MAPK131.10315832
46FGR1.10143140
47PIK3CG1.09563565
48TEC1.08298679
49SGK4941.04849908
50SGK2231.04849908
51CLK11.04215481
52MAP2K71.03190735
53MARK21.01627085
54CSNK1G11.00532013
55PIK3CA0.99005605
56TGFBR10.98775693
57WNK40.97987353
58CAMK2G0.95033044
59FGFR20.94428244
60INSRR0.94047558
61CAMK1D0.93805281
62CSNK1G20.93368604
63MAP3K40.91155367
64TXK0.89262165
65ADRBK20.88519385
66SGK20.88188773
67UHMK10.85084881
68CAMK2A0.84148942
69CAMK2B0.82865665
70PDK30.82206584
71PDK40.82206584
72NTRK10.81817517
73CAMKK20.77782189
74PRKCE0.77331634
75KIT0.76654833
76TNK20.73902376
77CDK50.73896070
78STK380.73806270
79PRKCH0.72296339
80PRKAA20.71038501
81LATS10.69416944
82PRKCQ0.68455797
83CSNK1A10.68019035
84MAP3K70.67847849
85STK30.66007264
86DYRK1A0.65926230
87NLK0.64632185
88SIK20.64629234
89CAMK2D0.63771158
90PRKD30.63684757
91OBSCN0.63522229
92TLK10.63315243
93PRPF4B0.62770487
94FES0.61682381
95IRAK20.59971881
96MAP2K60.59584881
97STK110.59177145
98CHUK0.58616262
99BRD40.58165887
100CDK30.58131552
101PBK0.56966997
102ROCK20.56846821
103LIMK10.56481945
104PRKACB0.55759652
105PAK30.54277309
106CAMK40.53168042
107ERBB20.52763649
108PRKG10.52138169
109FER0.50222385
110BMPR20.48709478
111PRKAA10.48556609
112ERBB40.48462473
113CSNK1D0.48113671
114PDK20.47828092
115PLK20.47151241
116EPHA30.45037960
117ITK0.44161458
118GRK70.43827565
119MELK0.43689024
120IRAK10.41776333
121DDR20.41014915
122PAK60.39326592
123IKBKB0.39009148
124MARK30.38669256
125MAPK70.37424378
126MAPK150.37327734
127CAMK10.36931245
128PRKACA0.36479642
129SGK10.36161774
130TIE10.35916207
131PRKCA0.35911986
132SYK0.35305912
133CDK150.34057869
134RPS6KA30.33724313
135CDK180.32705497
136PRKCB0.31769529
137CDK140.31101161
138MAPK120.31060646
139PRKCZ0.30798116
140TRPM70.30733264
141CSNK1E0.29785124
142PRKD20.29758567
143CDK11A0.29621589
144PTK2B0.29097984
145YES10.28976738

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.03332206
2Steroid biosynthesis_Homo sapiens_hsa001003.67024888
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.12186524
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95414386
5Fatty acid elongation_Homo sapiens_hsa000622.90979568
6Nicotine addiction_Homo sapiens_hsa050332.81761032
7Nitrogen metabolism_Homo sapiens_hsa009102.78505382
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57504973
9Fatty acid biosynthesis_Homo sapiens_hsa000612.54891264
10ABC transporters_Homo sapiens_hsa020102.25439723
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10296672
12Ether lipid metabolism_Homo sapiens_hsa005652.08162084
13Histidine metabolism_Homo sapiens_hsa003402.03892966
14Glutamatergic synapse_Homo sapiens_hsa047241.93999600
15Arginine and proline metabolism_Homo sapiens_hsa003301.92075024
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86485968
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79852819
18GABAergic synapse_Homo sapiens_hsa047271.65985871
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64264961
20Sulfur metabolism_Homo sapiens_hsa009201.59721442
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49344728
22Fatty acid metabolism_Homo sapiens_hsa012121.47610042
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.44851320
24Homologous recombination_Homo sapiens_hsa034401.44536058
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43008906
26Butanoate metabolism_Homo sapiens_hsa006501.39274546
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36148696
28Morphine addiction_Homo sapiens_hsa050321.34385679
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33632501
30Fanconi anemia pathway_Homo sapiens_hsa034601.27101423
31Linoleic acid metabolism_Homo sapiens_hsa005911.25415947
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24797768
33Cocaine addiction_Homo sapiens_hsa050301.23797408
34beta-Alanine metabolism_Homo sapiens_hsa004101.22364913
35Lysine degradation_Homo sapiens_hsa003101.18266330
36Vitamin digestion and absorption_Homo sapiens_hsa049771.17473733
37Serotonergic synapse_Homo sapiens_hsa047261.17216328
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15243708
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14557159
40Circadian entrainment_Homo sapiens_hsa047131.14358125
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14315159
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12199399
43Sphingolipid metabolism_Homo sapiens_hsa006001.09901095
44Amphetamine addiction_Homo sapiens_hsa050311.09521324
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.09518261
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07295133
47PPAR signaling pathway_Homo sapiens_hsa033201.04377435
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03574697
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.03264841
50Selenocompound metabolism_Homo sapiens_hsa004501.02904368
51Cholinergic synapse_Homo sapiens_hsa047250.98642006
52Oxytocin signaling pathway_Homo sapiens_hsa049210.96361092
53Axon guidance_Homo sapiens_hsa043600.95731869
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95624428
55Taste transduction_Homo sapiens_hsa047420.93858209
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92372638
57Cardiac muscle contraction_Homo sapiens_hsa042600.91983394
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.90758385
59Salivary secretion_Homo sapiens_hsa049700.90569019
60Autoimmune thyroid disease_Homo sapiens_hsa053200.90036944
61Glycerolipid metabolism_Homo sapiens_hsa005610.88663752
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87913645
63Chemical carcinogenesis_Homo sapiens_hsa052040.85665637
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84010687
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80685637
66Circadian rhythm_Homo sapiens_hsa047100.80436023
67Oxidative phosphorylation_Homo sapiens_hsa001900.80055363
68Mineral absorption_Homo sapiens_hsa049780.76583002
69Peroxisome_Homo sapiens_hsa041460.75397679
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75129478
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73981118
72Fatty acid degradation_Homo sapiens_hsa000710.71579905
73Retinol metabolism_Homo sapiens_hsa008300.71331663
74Propanoate metabolism_Homo sapiens_hsa006400.69834583
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69660899
76RNA polymerase_Homo sapiens_hsa030200.69178600
77Insulin secretion_Homo sapiens_hsa049110.68583814
78Folate biosynthesis_Homo sapiens_hsa007900.64761036
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64346368
80Gastric acid secretion_Homo sapiens_hsa049710.63112378
81Metabolic pathways_Homo sapiens_hsa011000.62663477
82Bile secretion_Homo sapiens_hsa049760.62433169
83Caffeine metabolism_Homo sapiens_hsa002320.62181094
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.61101859
85cAMP signaling pathway_Homo sapiens_hsa040240.59712282
86Calcium signaling pathway_Homo sapiens_hsa040200.58749762
87Type II diabetes mellitus_Homo sapiens_hsa049300.57586221
88Asthma_Homo sapiens_hsa053100.55851942
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54182182
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53664053
91Graft-versus-host disease_Homo sapiens_hsa053320.52891611
92Glutathione metabolism_Homo sapiens_hsa004800.52539634
93Long-term potentiation_Homo sapiens_hsa047200.50790920
94Arachidonic acid metabolism_Homo sapiens_hsa005900.50754990
95Long-term depression_Homo sapiens_hsa047300.50075577
96Regulation of autophagy_Homo sapiens_hsa041400.48811274
97Platelet activation_Homo sapiens_hsa046110.47618465
98Renin secretion_Homo sapiens_hsa049240.46671658
99Ovarian steroidogenesis_Homo sapiens_hsa049130.46613204
100Basal transcription factors_Homo sapiens_hsa030220.46586184
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46335929
102Alzheimers disease_Homo sapiens_hsa050100.46196300
103Olfactory transduction_Homo sapiens_hsa047400.45806650
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45692957
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45269520
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45098335
107Parkinsons disease_Homo sapiens_hsa050120.44660367
108Purine metabolism_Homo sapiens_hsa002300.41367172
109Dorso-ventral axis formation_Homo sapiens_hsa043200.39924492
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39220264
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.39013468
112Protein export_Homo sapiens_hsa030600.38450261
113MAPK signaling pathway_Homo sapiens_hsa040100.38295313
114Hedgehog signaling pathway_Homo sapiens_hsa043400.37925687
115Tryptophan metabolism_Homo sapiens_hsa003800.36712652
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35960464
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35757319
118Arginine biosynthesis_Homo sapiens_hsa002200.33814152
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31353576
120Ras signaling pathway_Homo sapiens_hsa040140.30226562
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29863949
122Malaria_Homo sapiens_hsa051440.29779359
123Phototransduction_Homo sapiens_hsa047440.29488705
124RNA degradation_Homo sapiens_hsa030180.29217323
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29153082
126Fat digestion and absorption_Homo sapiens_hsa049750.28773937
127Dilated cardiomyopathy_Homo sapiens_hsa054140.28669042
128Type I diabetes mellitus_Homo sapiens_hsa049400.28580561
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.27047320
130One carbon pool by folate_Homo sapiens_hsa006700.26728764
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26324245
132Dopaminergic synapse_Homo sapiens_hsa047280.25750532
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.24202596
134Pancreatic secretion_Homo sapiens_hsa049720.21524853

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