FAM229A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.82611057
2motile cilium assembly (GO:0044458)9.14222488
3epithelial cilium movement (GO:0003351)9.04611759
4plasma membrane fusion (GO:0045026)8.95974624
5axonemal dynein complex assembly (GO:0070286)8.86777438
6reproduction (GO:0000003)8.85980422
7regulation of cilium movement (GO:0003352)8.38926283
8negative regulation of inclusion body assembly (GO:0090084)8.23270921
9organic cation transport (GO:0015695)7.29982486
10spermatogenesis (GO:0007283)7.20341909
11cilium movement (GO:0003341)7.19189953
12male gamete generation (GO:0048232)7.17699283
13sperm capacitation (GO:0048240)7.16609067
14synaptonemal complex assembly (GO:0007130)7.12497785
15synaptonemal complex organization (GO:0070193)7.11559089
16chromosome condensation (GO:0030261)6.90024715
17single fertilization (GO:0007338)6.81058944
18regulation of inclusion body assembly (GO:0090083)6.78343649
19microtubule depolymerization (GO:0007019)6.65526341
20gamete generation (GO:0007276)6.58843421
21male meiosis (GO:0007140)6.49390895
22DNA packaging (GO:0006323)6.49071244
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.46238711
24cilium or flagellum-dependent cell motility (GO:0001539)6.20838494
25piRNA metabolic process (GO:0034587)6.00391741
26spermatid nucleus differentiation (GO:0007289)5.92799077
27calcium ion-dependent exocytosis (GO:0017156)5.92015884
28fertilization (GO:0009566)5.91413184
29germ cell development (GO:0007281)5.54202783
30sexual reproduction (GO:0019953)5.47773198
31glycerol ether metabolic process (GO:0006662)5.44635469
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.40869626
33multicellular organismal reproductive process (GO:0048609)5.16821876
34cell recognition (GO:0008037)5.09400268
35microtubule severing (GO:0051013)5.08000729
36negative regulation of erythrocyte differentiation (GO:0045647)5.07088937
37ether metabolic process (GO:0018904)5.02978846
38single strand break repair (GO:0000012)4.97155462
39regulation of microtubule-based movement (GO:0060632)4.94276253
40seminiferous tubule development (GO:0072520)4.71128656
41chromosome organization involved in meiosis (GO:0070192)4.69539424
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64566505
43ventricular system development (GO:0021591)4.62982582
44negative regulation of cell killing (GO:0031342)4.59605874
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59605874
46chaperone-mediated protein complex assembly (GO:0051131)4.47055137
47sequestering of actin monomers (GO:0042989)4.41058058
48male meiosis I (GO:0007141)4.35156086
49regulation of ARF GTPase activity (GO:0032312)4.20758452
50multicellular organismal development (GO:0007275)4.17865145
51histone H4 deacetylation (GO:0070933)4.13432075
52histone H3 deacetylation (GO:0070932)4.06799490
53left/right pattern formation (GO:0060972)4.05049462
54positive regulation of gamma-delta T cell activation (GO:0046645)3.98676504
55meiotic nuclear division (GO:0007126)3.92375254
56DNA methylation involved in gamete generation (GO:0043046)3.91370560
57mannose metabolic process (GO:0006013)3.86590422
58histone H3-K4 trimethylation (GO:0080182)3.76723070
59response to muramyl dipeptide (GO:0032495)3.76566359
60positive regulation of macrophage activation (GO:0043032)3.76138672
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.66894373
62protein polyglutamylation (GO:0018095)3.61473202
63histone H3-K9 demethylation (GO:0033169)3.60000298
64regulation of spindle checkpoint (GO:0090231)3.59263187
65protein K11-linked deubiquitination (GO:0035871)3.58614009
66negative regulation of cAMP-mediated signaling (GO:0043951)3.56475713
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.52526094
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.52526094
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.52526094
70modulation by symbiont of host immune response (GO:0052553)3.52526094
71positive regulation by symbiont of host defense response (GO:0052509)3.52526094
72modulation by symbiont of host defense response (GO:0052031)3.52526094
73phosphatidylethanolamine metabolic process (GO:0046337)3.50462293
74polyamine biosynthetic process (GO:0006596)3.48576520
75meiosis I (GO:0007127)3.46559977
76interferon-gamma secretion (GO:0072643)3.46029667
77positive regulation of histone deacetylation (GO:0031065)3.43622640
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.43478684
79tolerance induction (GO:0002507)3.43455990
80protein refolding (GO:0042026)3.41657854
81microtubule polymerization or depolymerization (GO:0031109)3.39492082
82chromatin silencing (GO:0006342)3.36720970
83regulation of histone H3-K27 methylation (GO:0061085)3.34646262
84regulation of Rab GTPase activity (GO:0032313)3.32989469
85positive regulation of Rab GTPase activity (GO:0032851)3.32989469
86positive thymic T cell selection (GO:0045059)3.30361807
87regulation of gamma-delta T cell activation (GO:0046643)3.29586146
88regulation of ARF protein signal transduction (GO:0032012)3.27069224
89nucleus organization (GO:0006997)3.25198490
90RNA destabilization (GO:0050779)3.24994739
91genitalia morphogenesis (GO:0035112)3.21963383
92glycolytic process (GO:0006096)3.21774749
93negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21469042
94positive regulation of CREB transcription factor activity (GO:0032793)3.19806574
95intracellular estrogen receptor signaling pathway (GO:0030520)3.17657364
96mitotic sister chromatid cohesion (GO:0007064)3.16099066
97regulation of chromatin binding (GO:0035561)3.14784465
98regulation of gamma-delta T cell differentiation (GO:0045586)3.13626751
99regulation of T-helper 2 cell differentiation (GO:0045628)3.12255254
100carnitine transport (GO:0015879)3.11673303
101amino-acid betaine transport (GO:0015838)3.11673303
102RNA localization (GO:0006403)3.09036294
103negative regulation of Rho protein signal transduction (GO:0035024)3.05716400
104thymic T cell selection (GO:0045061)3.03829208
105meiotic cell cycle (GO:0051321)3.02725886
106positive regulation of protein deacetylation (GO:0090312)3.02722037
107response to pheromone (GO:0019236)2.99619953
108positive T cell selection (GO:0043368)2.97000314
109mitochondrion degradation (GO:0000422)2.95153702
110positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94897645
111histone lysine demethylation (GO:0070076)2.94019782
112nucleoside diphosphate phosphorylation (GO:0006165)2.93770074
113carnitine transmembrane transport (GO:1902603)2.91699055
114response to peptidoglycan (GO:0032494)2.90704707
115histone H3-K9 modification (GO:0061647)2.90620884
116histone demethylation (GO:0016577)2.89151717
117membrane protein intracellular domain proteolysis (GO:0031293)2.88646301
118cell-cell junction maintenance (GO:0045217)2.86028076
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84540757
120negative regulation of lymphocyte mediated immunity (GO:0002707)2.83582625
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81770731
122regulation of interferon-beta biosynthetic process (GO:0045357)2.81445587
123negative thymic T cell selection (GO:0045060)2.80058184
124regulation of cilium assembly (GO:1902017)2.79205948
1253-UTR-mediated mRNA stabilization (GO:0070935)2.78139986
126modulation by virus of host process (GO:0019054)2.77761479
127T cell selection (GO:0045058)2.76996249
128erythrocyte maturation (GO:0043249)2.76769314
129negative regulation of histone methylation (GO:0031061)2.76526778
130regulation of histone deacetylation (GO:0031063)2.76329398
131detection of bacterium (GO:0016045)2.73686998
132antigen processing and presentation of endogenous antigen (GO:0019883)2.72452994
133negative regulation of granulocyte differentiation (GO:0030853)2.72394871
134protein-DNA complex disassembly (GO:0032986)2.72316260
135nucleosome disassembly (GO:0006337)2.72316260
136polyol catabolic process (GO:0046174)2.71566145
137GTP biosynthetic process (GO:0006183)2.71479985
138alditol metabolic process (GO:0019400)2.70774812
139macrophage activation involved in immune response (GO:0002281)2.70006358
140meiotic cell cycle process (GO:1903046)2.67194653
141protein localization to cilium (GO:0061512)2.64410327
142leukocyte aggregation (GO:0070486)2.63679567
143regulation of granulocyte differentiation (GO:0030852)2.63496594
144response to acidic pH (GO:0010447)2.63132935
145detection of other organism (GO:0098543)2.62129289
146negative regulation of T cell mediated immunity (GO:0002710)2.61985966
147response to interleukin-15 (GO:0070672)2.61270886
148negative T cell selection (GO:0043383)2.60903335
149peptidyl-lysine trimethylation (GO:0018023)2.60616719
150negative regulation of gene expression, epigenetic (GO:0045814)2.57996450
151germinal center formation (GO:0002467)2.57050992
152T cell homeostasis (GO:0043029)2.56725605
153synapsis (GO:0007129)2.56285957
154protein targeting to Golgi (GO:0000042)2.56260387
155histone H3-K36 demethylation (GO:0070544)2.55833453
156peptide catabolic process (GO:0043171)2.55527082
157protein demethylation (GO:0006482)2.54218757
158protein dealkylation (GO:0008214)2.54218757
159cell migration in hindbrain (GO:0021535)2.52443681
160histone deubiquitination (GO:0016578)2.52124843
161antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52107484
162regulation of mast cell degranulation (GO:0043304)2.51756090
163NIK/NF-kappaB signaling (GO:0038061)2.50366889
164retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49918367
165monoubiquitinated protein deubiquitination (GO:0035520)2.47324178
166histone H3-K4 methylation (GO:0051568)2.46868291
167oxygen transport (GO:0015671)2.44568485
168peptidyl-glutamic acid modification (GO:0018200)2.44189935
169cilium organization (GO:0044782)2.43929854
170positive regulation of glycolytic process (GO:0045821)2.43721346
171natural killer cell differentiation (GO:0001779)2.43490872
172cellular component assembly involved in morphogenesis (GO:0010927)2.43390113
173positive regulation of granulocyte differentiation (GO:0030854)2.43125588
174protein localization to chromosome, centromeric region (GO:0071459)2.43086312
175UTP biosynthetic process (GO:0006228)2.42634214
176cilium morphogenesis (GO:0060271)2.36595401
177amine biosynthetic process (GO:0009309)2.35564547
178sperm motility (GO:0030317)14.4982757
179cell wall macromolecule catabolic process (GO:0016998)14.0503498
180cell wall macromolecule metabolic process (GO:0044036)14.0503498
181acrosome reaction (GO:0007340)13.1056220
182acrosome assembly (GO:0001675)12.0502300
183fusion of sperm to egg plasma membrane (GO:0007342)11.7887475
184sperm-egg recognition (GO:0035036)11.7168540
185binding of sperm to zona pellucida (GO:0007339)10.7967970
186cell-cell recognition (GO:0009988)10.5039393
187spermatid development (GO:0007286)10.0994541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.73670141
2EZH2_22144423_ChIP-Seq_EOC_Human4.01648804
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.71511044
4VDR_21846776_ChIP-Seq_THP-1_Human3.18892386
5LXR_22292898_ChIP-Seq_THP-1_Human3.01411807
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00691274
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95573382
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.94715873
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93242798
10MYC_22102868_ChIP-Seq_BL_Human2.92576179
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.77776006
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73538580
13VDR_22108803_ChIP-Seq_LS180_Human2.67349612
14KDM2B_26808549_Chip-Seq_DND41_Human2.63330497
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.60053784
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.52786769
17TCF7_22412390_ChIP-Seq_EML_Mouse2.49599496
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40812106
19P68_20966046_ChIP-Seq_HELA_Human2.38121195
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34816731
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.31746468
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25646965
23MAF_26560356_Chip-Seq_TH2_Human2.21922506
24MAF_26560356_Chip-Seq_TH1_Human2.16755022
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.11394613
26KDM2B_26808549_Chip-Seq_K562_Human2.07558255
27ZNF274_21170338_ChIP-Seq_K562_Hela2.06368999
28UTX_26944678_Chip-Seq_JUKART_Human2.04230844
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03037311
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01788286
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.98014145
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97970851
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94662941
34SMC4_20622854_ChIP-Seq_HELA_Human1.93069805
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.89691405
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86798197
37VDR_24763502_ChIP-Seq_THP-1_Human1.86625411
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.84435847
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82016139
40KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80297571
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.79951493
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79321073
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.76373061
44NCOR1_26117541_ChIP-Seq_K562_Human1.75460897
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70151511
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69621553
47STAT1_17558387_ChIP-Seq_HELA_Human1.69323950
48FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66419763
49E2F1_20622854_ChIP-Seq_HELA_Human1.64627922
50CREB1_26743006_Chip-Seq_LNCaP_Human1.63410459
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62125415
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60575725
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.60541543
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60124370
55RACK7_27058665_Chip-Seq_MCF-7_Human1.59994240
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59991721
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57631182
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56469736
59GATA1_19941826_ChIP-Seq_K562_Human1.56191354
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.54702119
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54213726
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.50052495
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49870530
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49378322
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48105717
66P53_21459846_ChIP-Seq_SAOS-2_Human1.47361983
67SPI1_23127762_ChIP-Seq_K562_Human1.47023673
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.46089688
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43264707
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.42423245
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.40108764
72CIITA_25753668_ChIP-Seq_RAJI_Human1.39516220
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.39275797
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39154191
75SA1_27219007_Chip-Seq_Bcells_Human1.37899620
76KDM2B_26808549_Chip-Seq_REH_Human1.36261858
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.35736067
78REST_21632747_ChIP-Seq_MESCs_Mouse1.35158835
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35137118
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34874969
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34077574
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34056026
83CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33341883
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32669861
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32105020
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31293473
87OCT4_19829295_ChIP-Seq_ESCs_Human1.30929480
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.30377376
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30144032
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29423769
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29230585
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29101853
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.28953927
94SPI1_26923725_Chip-Seq_HPCs_Mouse1.28661459
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.28552595
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28549672
97CBP_20019798_ChIP-Seq_JUKART_Human1.28543279
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28543279
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28147057
100GF1_26923725_Chip-Seq_HPCs_Mouse1.27953949
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27098146
102MYB_26560356_Chip-Seq_TH1_Human1.25863736
103RUNX_20019798_ChIP-Seq_JUKART_Human1.25550315
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25034626
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24513426
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24108796
107GATA1_19941827_ChIP-Seq_MEL86_Mouse1.23264563
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23171533
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23087477
110TP63_22573176_ChIP-Seq_HFKS_Human1.23004282
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22661581
112CTCF_21964334_Chip-Seq_Bcells_Human1.22510398
113SCL_19346495_ChIP-Seq_HPC-7_Human1.21911294
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21816873
115MYC_27129775_Chip-Seq_CORNEA_Mouse1.21749918
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20708658
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.20494133
118KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20092282
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.18632683
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17759960
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17665859
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.17615157
123DROSHA_22980978_ChIP-Seq_HELA_Human1.16742588
124P300_27268052_Chip-Seq_Bcells_Human1.16638432
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15616968
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15410608
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15368594
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15187075
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.14886518
130NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14664826
131RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14371405
132BCOR_27268052_Chip-Seq_Bcells_Human1.13559320
133CTCF_20526341_ChIP-Seq_ESCs_Human1.13219273
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13078784
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11822458
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11617089
137ESET_19884257_ChIP-Seq_ESCs_Mouse1.11345147
138ERG_21242973_ChIP-ChIP_JURKAT_Human1.11283051
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10506120
140SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10135637
141ERG_20517297_ChIP-Seq_VCAP_Human1.09736448
142ERA_21632823_ChIP-Seq_H3396_Human1.09560648
143CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09215094
144RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09197634
145ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09078826
146ELF1_20517297_ChIP-Seq_JURKAT_Human1.07930976
147TP53_22127205_ChIP-Seq_IMR90_Human1.07454787
148FOXP1_21924763_ChIP-Seq_HESCs_Human1.06220893
149SOX11_22085726_ChIP-Seq_ESNs_Mouse1.06060189
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06057496
151BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05641416
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05176025
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05176025
154ETS1_21867929_ChIP-Seq_TH2_Mouse1.04972970
155SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04937580
156SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04756445
157RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04222444
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03898596
159RARB_24833708_ChIP-Seq_LIVER_Mouse1.03411767
160SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02712858
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02682774
162BCL6_27268052_Chip-Seq_Bcells_Human1.01352848
163PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00796977
164RAC3_21632823_ChIP-Seq_H3396_Human1.00614328
165RUNX1_27514584_Chip-Seq_MCF-7_Human1.00505192
166CBX2_27304074_Chip-Seq_ESCs_Mouse1.00420257
167DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99908395
168FLI1_21867929_ChIP-Seq_CD8_Mouse0.99662874
169SPI1_20517297_ChIP-Seq_HL60_Human0.99554095
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99095083
171TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98908868
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98540434
173PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98344944
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.97187465
175PHF8_20622854_ChIP-Seq_HELA_Human0.95927108
176TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95611198
177ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95520135
178CTCF_27219007_Chip-Seq_Bcells_Human0.95012353
179NANOG_20526341_ChIP-Seq_ESCs_Human0.93163603
180PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93049521
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92146022
182LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91379063
183CTCF_26484167_Chip-Seq_Bcells_Mouse0.91278636
184NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90274084
185CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90234977
186CRX_20693478_ChIP-Seq_RETINA_Mouse0.88238625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.01753403
2MP0001929_abnormal_gametogenesis5.57046979
3MP0003436_decreased_susceptibility_to3.62575068
4MP0008877_abnormal_DNA_methylation3.50989019
5MP0002161_abnormal_fertility/fecundity3.28881446
6MP0002210_abnormal_sex_determination3.20109036
7MP0005670_abnormal_white_adipose3.16884037
8MP0005451_abnormal_body_composition3.01709649
9MP0003172_abnormal_lysosome_physiology3.00728227
10MP0001145_abnormal_male_reproductive2.73799659
11MP0003303_peritoneal_inflammation2.64024589
12MP0002132_abnormal_respiratory_system2.48848961
13MP0000653_abnormal_sex_gland2.35335420
14MP0001348_abnormal_lacrimal_gland2.27080216
15MP0000678_abnormal_parathyroid_gland2.17528152
16MP0001873_stomach_inflammation2.00389082
17MP0005410_abnormal_fertilization16.9544445
18MP0008260_abnormal_autophagy1.96592948
19MP0000685_abnormal_immune_system1.85873431
20MP0001800_abnormal_humoral_immune1.84235079
21MP0003763_abnormal_thymus_physiology1.78652512
22MP0002653_abnormal_ependyma_morphology1.74684801
23MP0002249_abnormal_larynx_morphology1.74388962
24MP0002419_abnormal_innate_immunity1.73799170
25MP0009333_abnormal_splenocyte_physiolog1.73768959
26MP0005025_abnormal_response_to1.71649890
27MP0003724_increased_susceptibility_to1.68097543
28MP0004233_abnormal_muscle_weight1.66871947
29MP0003656_abnormal_erythrocyte_physiolo1.64100769
30MP0002723_abnormal_immune_serum1.61019789
31MP0000703_abnormal_thymus_morphology1.60991214
32MP0003646_muscle_fatigue1.59486008
33MP0002398_abnormal_bone_marrow1.58344886
34MP0002420_abnormal_adaptive_immunity1.54370780
35MP0001819_abnormal_immune_cell1.52882886
36MP0001790_abnormal_immune_system1.52726834
37MP0005387_immune_system_phenotype1.52726834
38MP0005000_abnormal_immune_tolerance1.51295541
39MP0005423_abnormal_somatic_nervous1.49519208
40MP0004947_skin_inflammation1.49044585
41MP0005464_abnormal_platelet_physiology1.47481428
42MP0004510_myositis1.45366926
43MP0002160_abnormal_reproductive_system1.44230241
44MP0002138_abnormal_hepatobiliary_system1.41937929
45MP0003123_paternal_imprinting1.40971299
46MP0005360_urolithiasis1.39106149
47MP0001986_abnormal_taste_sensitivity1.37716713
48MP0001835_abnormal_antigen_presentation1.36663968
49MP0002933_joint_inflammation1.35926206
50MP0002405_respiratory_system_inflammati1.35336355
51MP0005083_abnormal_biliary_tract1.35265683
52MP0002452_abnormal_antigen_presenting1.34571423
53MP0000716_abnormal_immune_system1.34224241
54MP0001502_abnormal_circadian_rhythm1.30378691
55MP0004130_abnormal_muscle_cell1.28312365
56MP0001533_abnormal_skeleton_physiology1.27808068
57MP0002722_abnormal_immune_system1.27735009
58MP0005058_abnormal_lysosome_morphology1.26876903
59MP0002234_abnormal_pharynx_morphology1.24564767
60MP0005671_abnormal_response_to1.21845267
61MP0004859_abnormal_synaptic_plasticity1.19602662
62MP0002429_abnormal_blood_cell1.19452691
63MP0000689_abnormal_spleen_morphology1.12662329
64MP0003300_gastrointestinal_ulcer1.08687342
65MP0001984_abnormal_olfaction1.06470160
66MP0008961_abnormal_basal_metabolism1.05273926
67MP0005535_abnormal_body_temperature1.05198820
68MP0004381_abnormal_hair_follicle1.04863533
69MP0001663_abnormal_digestive_system1.04577852
70MP0001765_abnormal_ion_homeostasis1.03299750
71MP0005623_abnormal_meninges_morphology1.01673624
72MP0005310_abnormal_salivary_gland1.00005907
73MP0009785_altered_susceptibility_to0.99745602
74MP0009764_decreased_sensitivity_to0.99132978
75MP0004185_abnormal_adipocyte_glucose0.97600525
76MP0003122_maternal_imprinting0.97442060
77MP0003866_abnormal_defecation0.96167636
78MP0005076_abnormal_cell_differentiation0.95693401
79MP0002396_abnormal_hematopoietic_system0.95076425
80MP0000681_abnormal_thyroid_gland0.92749018
81MP0004858_abnormal_nervous_system0.92403703
82MP0002998_abnormal_bone_remodeling0.91280877
83MP0000609_abnormal_liver_physiology0.91270339
84MP0003191_abnormal_cellular_cholesterol0.89126147
85MP0005409_darkened_coat_color0.88770115
86MP0010155_abnormal_intestine_physiology0.88301926
87MP0003705_abnormal_hypodermis_morpholog0.85187256
88MP0002282_abnormal_trachea_morphology0.84373269
89MP0001188_hyperpigmentation0.82725529
90MP0000003_abnormal_adipose_tissue0.82390762
91MP0002970_abnormal_white_adipose0.80893680
92MP0006292_abnormal_olfactory_placode0.80810902
93MP0008469_abnormal_protein_level0.79713257
94MP0003828_pulmonary_edema0.79208176
95MP0001845_abnormal_inflammatory_respons0.77378308
96MP0005334_abnormal_fat_pad0.76635583
97MP0008058_abnormal_DNA_repair0.74056394
98MP0000015_abnormal_ear_pigmentation0.72017138
99MP0005389_reproductive_system_phenotype0.68652404
100MP0003115_abnormal_respiratory_system0.67735744
101MP0005636_abnormal_mineral_homeostasis0.67120691
102MP0000955_abnormal_spinal_cord0.66645540
103MP0002736_abnormal_nociception_after0.65140134
104MP0005647_abnormal_sex_gland0.64916554
105MP0004036_abnormal_muscle_relaxation0.64878823
106MP0003329_amyloid_beta_deposits0.64283103
107MP0009046_muscle_twitch0.61289107
108MP0002269_muscular_atrophy0.60897235
109MP0003011_delayed_dark_adaptation0.60547886
110MP0006036_abnormal_mitochondrial_physio0.58871888
111MP0005666_abnormal_adipose_tissue0.54388129
112MP0001764_abnormal_homeostasis0.54270754
113MP0004133_heterotaxia0.53249864
114MP0005377_hearing/vestibular/ear_phenot0.53038815
115MP0003878_abnormal_ear_physiology0.53038815
116MP0000534_abnormal_ureter_morphology0.47881097
117MP0005397_hematopoietic_system_phenotyp0.47498687
118MP0001545_abnormal_hematopoietic_system0.47498687
119MP0000604_amyloidosis0.46962882
120MP0001293_anophthalmia0.44653253
121MP0000358_abnormal_cell_content/0.43618218
122MP0003699_abnormal_female_reproductive0.43196345
123MP0009278_abnormal_bone_marrow0.42459152
124MP0008995_early_reproductive_senescence0.41309873
125MP0001324_abnormal_eye_pigmentation0.41005781
126MP0001968_abnormal_touch/_nociception0.39298809
127MP0009115_abnormal_fat_cell0.34450184
128MP0004811_abnormal_neuron_physiology0.33720321
129MP0002139_abnormal_hepatobiliary_system0.31617967
130MP0001730_embryonic_growth_arrest0.31617202
131MP0003942_abnormal_urinary_system0.31107174
132MP0005253_abnormal_eye_physiology0.30685350
133MP0003111_abnormal_nucleus_morphology0.29746212
134MP0002169_no_abnormal_phenotype0.28880729
135MP0002873_normal_phenotype0.28691107
136MP0010094_abnormal_chromosome_stability0.27140408
137MP0003633_abnormal_nervous_system0.27102184
138MP0006035_abnormal_mitochondrial_morpho0.26428758
139MP0001849_ear_inflammation0.26011768
140MP0005551_abnormal_eye_electrophysiolog0.25861492
141MP0003806_abnormal_nucleotide_metabolis0.25782040
142MP0002909_abnormal_adrenal_gland0.25699990
143MP0002928_abnormal_bile_duct0.25073131
144MP0004084_abnormal_cardiac_muscle0.23993730
145MP0003948_abnormal_gas_homeostasis0.23784690
146MP0005391_vision/eye_phenotype0.23611619
147MP0003861_abnormal_nervous_system0.23299249
148MP0003879_abnormal_hair_cell0.22432718
149MP0002971_abnormal_brown_adipose0.22064693
150MP0003631_nervous_system_phenotype0.21747178
151MP0004145_abnormal_muscle_electrophysio0.21259823
152MP0008875_abnormal_xenobiotic_pharmacok0.21184445
153MP0002152_abnormal_brain_morphology0.20831380
154MP0000462_abnormal_digestive_system0.20549908
155MP0003950_abnormal_plasma_membrane0.18838272
156MP0003787_abnormal_imprinting0.18317190
157MP0001119_abnormal_female_reproductive0.17092998
158MP0000001_mammalian_phenotype0.16780036
159MP0002295_abnormal_pulmonary_circulatio0.16755428
160MP0004043_abnormal_pH_regulation0.16313674
161MP0004019_abnormal_vitamin_homeostasis0.16284233
162MP0000569_abnormal_digit_pigmentation0.16033299
163MP0005319_abnormal_enzyme/_coenzyme0.15937999
164MP0005375_adipose_tissue_phenotype0.15120500
165MP0008770_decreased_survivor_rate0.15032796
166MP0010307_abnormal_tumor_latency0.14486636
167MP0004270_analgesia0.14412734
168MP0008569_lethality_at_weaning0.14206049
169MP0002106_abnormal_muscle_physiology0.12854654
170MP0005365_abnormal_bile_salt0.12821155
171MP0002092_abnormal_eye_morphology0.12787026
172MP0002837_dystrophic_cardiac_calcinosis0.12753411
173MP0000313_abnormal_cell_death0.12733619
174MP0002822_catalepsy0.12576041
175MP0002084_abnormal_developmental_patter0.11856647
176MP0002229_neurodegeneration0.11465309
177MP0004742_abnormal_vestibular_system0.11417385
178MP0001697_abnormal_embryo_size0.11202436
179MP0002693_abnormal_pancreas_physiology0.11040780
180MP0002118_abnormal_lipid_homeostasis0.10973570

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31467793
2Abnormal respiratory epithelium morphology (HP:0012253)9.07281082
3Abnormal respiratory motile cilium morphology (HP:0005938)9.07281082
4Chronic bronchitis (HP:0004469)7.63666243
5Infertility (HP:0000789)7.39160498
6Rhinitis (HP:0012384)7.36928676
7Abnormal ciliary motility (HP:0012262)7.06414292
8Nasal polyposis (HP:0100582)6.52201521
9Abnormality of the nasal mucosa (HP:0000433)5.36097008
10Male infertility (HP:0003251)5.16598153
11Bronchitis (HP:0012387)4.58270992
12Bronchiectasis (HP:0002110)4.33063627
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.20755224
14Nephronophthisis (HP:0000090)3.91924140
15Abnormal spermatogenesis (HP:0008669)3.86867828
16Severe visual impairment (HP:0001141)3.82689033
17Obstructive lung disease (HP:0006536)3.62285199
18Chronic obstructive pulmonary disease (HP:0006510)3.62285199
19Reticulocytosis (HP:0001923)3.61965958
20Eczematoid dermatitis (HP:0000976)3.58301243
21Hypochromic microcytic anemia (HP:0004840)3.57694437
22Hyperthyroidism (HP:0000836)3.57277362
23Hypochromic anemia (HP:0001931)3.51308485
24Abnormality of the fingertips (HP:0001211)3.39787799
25Obstructive sleep apnea (HP:0002870)3.32709300
26Recurrent otitis media (HP:0000403)3.22977149
27Panhypogammaglobulinemia (HP:0003139)3.17081722
28Seborrheic dermatitis (HP:0001051)3.08879384
29Recurrent sinusitis (HP:0011108)3.01204895
30Gastrointestinal infarctions (HP:0005244)2.99162310
31Truncus arteriosus (HP:0001660)2.91878078
32Prolonged bleeding time (HP:0003010)2.91189189
33Abnormality of the aortic arch (HP:0012303)2.90041598
34Abnormality of the renal medulla (HP:0100957)2.87077332
35Cholecystitis (HP:0001082)2.84099323
36Abnormal gallbladder physiology (HP:0012438)2.84099323
37Deep palmar crease (HP:0006191)2.82440151
38Hypertensive crisis (HP:0100735)2.76324559
39Elevated erythrocyte sedimentation rate (HP:0003565)2.72045826
40Neonatal hypoglycemia (HP:0001998)2.72015394
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.71617431
42Myositis (HP:0100614)2.69034873
43Abnormality of reticulocytes (HP:0004312)2.66380481
44Colitis (HP:0002583)2.64896890
45Impulsivity (HP:0100710)2.62986804
46Tubular atrophy (HP:0000092)2.62185358
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.59494184
48Aplasia/Hypoplasia of the thymus (HP:0010515)2.58997112
49Molar tooth sign on MRI (HP:0002419)2.57649342
50Abnormality of midbrain morphology (HP:0002418)2.57649342
51Bowel incontinence (HP:0002607)2.57581355
52Recurrent bronchitis (HP:0002837)2.54674158
53Congenital malformation of the right heart (HP:0011723)2.52254887
54Double outlet right ventricle (HP:0001719)2.52254887
55Gingivitis (HP:0000230)2.50974578
56Recurrent fungal infections (HP:0002841)2.50377187
57Hypoplasia of the thymus (HP:0000778)2.48549412
58Meningitis (HP:0001287)2.46442557
59Atelectasis (HP:0100750)2.45752337
60Abnormality of macrophages (HP:0004311)2.45015672
61Gastrointestinal inflammation (HP:0004386)2.42954716
62Tubulointerstitial nephritis (HP:0001970)2.41478005
63Azoospermia (HP:0000027)2.40356138
64Metaphyseal cupping (HP:0003021)2.39753250
65Papilledema (HP:0001085)2.37467532
66Recurrent abscess formation (HP:0002722)2.37249423
67Abnormal large intestine physiology (HP:0012700)2.37006122
68Tubulointerstitial abnormality (HP:0001969)2.36457109
69Increased IgE level (HP:0003212)2.34841154
70Orchitis (HP:0100796)2.30076140
71Recurrent bacterial skin infections (HP:0005406)2.29907084
72Hypoparathyroidism (HP:0000829)2.28872532
73Dyschromatopsia (HP:0007641)2.28037778
74Broad face (HP:0000283)2.28007304
75Recurrent gram-negative bacterial infections (HP:0005420)2.25846424
76Choroideremia (HP:0001139)2.24975014
77Medial flaring of the eyebrow (HP:0010747)2.23962197
78Inflammation of the large intestine (HP:0002037)2.19809471
79Thin bony cortex (HP:0002753)2.19727698
80Deep venous thrombosis (HP:0002625)2.18831277
81Disproportionate tall stature (HP:0001519)2.17585200
82Tubulointerstitial fibrosis (HP:0005576)2.15499732
83Aplasia/Hypoplasia of the earlobes (HP:0009906)2.15337320
84Optic neuritis (HP:0100653)2.12800575
85Retrobulbar optic neuritis (HP:0100654)2.12800575
86Poikilocytosis (HP:0004447)2.10060315
87Mediastinal lymphadenopathy (HP:0100721)2.09596073
88Rectal prolapse (HP:0002035)2.04912988
89Spontaneous hematomas (HP:0007420)2.04742138
90Cellulitis (HP:0100658)2.04383471
91Decreased central vision (HP:0007663)2.03787812
92Peripheral hypomyelination (HP:0007182)2.03618616
93Abnormality of DNA repair (HP:0003254)2.02343676
94Bony spicule pigmentary retinopathy (HP:0007737)2.00317173
95Dynein arm defect of respiratory motile cilia (HP:0012255)13.0967896
96Absent/shortened dynein arms (HP:0200106)13.0967896
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9081999
98Polycythemia (HP:0001901)1.98553784
99Gonadotropin excess (HP:0000837)1.98300168
100Hypertriglyceridemia (HP:0002155)1.98050997
101Long palpebral fissure (HP:0000637)1.97731047
102Encephalitis (HP:0002383)1.96520413
103Microcytic anemia (HP:0001935)1.95481037
104Truncal obesity (HP:0001956)1.94907553
105Supernumerary ribs (HP:0005815)1.94573674
106Peritonitis (HP:0002586)1.94536274
107Epistaxis (HP:0000421)1.93978438
108Segmental peripheral demyelination/remyelination (HP:0003481)1.93733165
109Neurofibrillary tangles (HP:0002185)1.90827465
110Pustule (HP:0200039)1.90471123
111Abnormal rod and cone electroretinograms (HP:0008323)1.90438853
112Slow saccadic eye movements (HP:0000514)1.89565643
113Hemorrhage of the eye (HP:0011885)1.88426391
114Stomatitis (HP:0010280)1.87456993
115Poikiloderma (HP:0001029)1.86828676
116Abnormal hemoglobin (HP:0011902)1.85968271
117Abnormality of the thymus (HP:0000777)1.85859879
118Abnormal drinking behavior (HP:0030082)1.85113005
119Polydipsia (HP:0001959)1.85113005
120Purpura (HP:0000979)1.84095411
121Chronic mucocutaneous candidiasis (HP:0002728)1.83539438
122Recurrent cutaneous fungal infections (HP:0011370)1.83539438
123Spastic tetraparesis (HP:0001285)1.83520683
124Exercise-induced myalgia (HP:0003738)1.83440629
125Episodic fever (HP:0001954)1.82013409
126Basal cell carcinoma (HP:0002671)1.81044191
127Abnormality of the thoracic spine (HP:0100711)1.79620231
128Thoracic kyphosis (HP:0002942)1.78862743
129Joint hemorrhage (HP:0005261)1.77854408
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77703609
131Vasculitis (HP:0002633)1.77120742
132Germ cell neoplasia (HP:0100728)1.75078511
133Diastasis recti (HP:0001540)1.70571102
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70354665
135Recurrent skin infections (HP:0001581)1.69271352
136Myoglobinuria (HP:0002913)1.67695912
137Increased serum ferritin (HP:0003281)1.67409250
138Stage 5 chronic kidney disease (HP:0003774)1.66517391
139Abnormality of renal excretion (HP:0011036)1.65790855
140Chest pain (HP:0100749)1.65607010
141Easy fatigability (HP:0003388)1.65583715
142Amblyopia (HP:0000646)1.64668240
143Postaxial foot polydactyly (HP:0001830)1.60207429
144Bile duct proliferation (HP:0001408)1.59832093
145Abnormal biliary tract physiology (HP:0012439)1.59832093
146Congenital hepatic fibrosis (HP:0002612)1.58828461
147Exercise-induced muscle cramps (HP:0003710)1.56567273
148Asymmetric septal hypertrophy (HP:0001670)1.55760552
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55317596
150Cerebral inclusion bodies (HP:0100314)1.53926017
151Aplasia/Hypoplasia of the lens (HP:0008063)1.53709861
152Rhabdomyolysis (HP:0003201)1.52039355
153Fatigable weakness (HP:0003473)1.49076005
154Abnormality of the neuromuscular junction (HP:0003398)1.49076005
155Heterotopia (HP:0002282)1.48305570
156Abnormal urine output (HP:0012590)1.47282158
157Sensory axonal neuropathy (HP:0003390)1.46662477
158Bundle branch block (HP:0011710)1.46374140
159Abnormality of the renal cortex (HP:0011035)1.43161845
160Oculomotor apraxia (HP:0000657)1.43092852
161Short ribs (HP:0000773)1.39010280
162Loss of speech (HP:0002371)1.38614802
163Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.36271905
164Hypercholesterolemia (HP:0003124)1.36151965
165Bell-shaped thorax (HP:0001591)1.34892091
166Cerebellar dysplasia (HP:0007033)1.34447828
167Constricted visual fields (HP:0001133)1.34365984
168Abnormal connection of the cardiac segments (HP:0011545)1.34153773
169Abnormal ventriculo-arterial connection (HP:0011563)1.34153773
170Transposition of the great arteries (HP:0001669)1.34153773
171Retinal dysplasia (HP:0007973)1.33852801
172Facial cleft (HP:0002006)1.32782459
173Decreased muscle mass (HP:0003199)1.31441502
174Renal dysplasia (HP:0000110)1.31141984
175Neoplasm of the heart (HP:0100544)1.29764045
176Postaxial hand polydactyly (HP:0001162)1.29411799
177Deformed sella turcica (HP:0002681)1.28344990
178Type 2 muscle fiber atrophy (HP:0003554)1.27778021
179Generalized muscle weakness (HP:0003324)1.26287783
180Abnormality of dentin (HP:0010299)1.26233650
181Bulbar palsy (HP:0001283)1.26081900
182Abnormality of permanent molar morphology (HP:0011071)1.25151726
183Abnormality of the dental root (HP:0006486)1.25151726
184Taurodontia (HP:0000679)1.25151726
185Cystic liver disease (HP:0006706)1.22662866
186Abnormality of saccadic eye movements (HP:0000570)1.21524481
187Aplasia/Hypoplasia affecting the retina (HP:0008061)1.21384296
188Cleft eyelid (HP:0000625)1.21089394
189Global brain atrophy (HP:0002283)1.20774985
190Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.20380003
191Absent epiphyses (HP:0010577)1.20380003
192Polyuria (HP:0000103)1.20329214
193Abnormality of the dental pulp (HP:0006479)1.19394360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.48035106
2PDK47.48035106
3TESK17.37124170
4PRKD35.21353881
5ICK5.15194462
6PDK24.89874704
7PRPF4B3.02436225
8ERN12.90672474
9SIK22.66672647
10MAP4K12.58941039
11PTK2B2.28726526
12STK382.23421513
13CDK122.16759721
14WNK42.14385508
15SIK12.13757689
16MAP2K32.11407007
17STK392.07259965
18TNK21.86023104
19DYRK1B1.78229464
20SIK31.71291286
21NEK21.68536584
22MAP3K111.65973064
23BRD41.63813254
24MAP3K71.57261615
25PDK11.44185976
26SMG11.43121929
27KSR21.42864620
28GRK61.42840850
29FGFR41.33949497
30IRAK41.31095270
31PRKD21.23978201
32BTK1.19740802
33PNCK1.18073015
34CSK1.16822186
35CAMK1D1.15313439
36DDR21.14737122
37BLK1.14572891
38TYK21.14396517
39FES1.08530000
40PDPK11.07211071
41DYRK31.04997838
42RPS6KA21.04238571
43TAOK11.04159857
44RPS6KL11.03221483
45RPS6KC11.03221483
46SGK31.02045628
47CDK190.99936914
48MAP3K130.99383321
49JAK30.96731566
50RIPK40.94995108
51CDC42BPA0.93680079
52MAP3K60.93193090
53HIPK20.91132602
54EPHB10.90842269
55RPS6KA60.90818412
56IRAK10.85971648
57TYRO30.85834937
58HCK0.85812340
59EEF2K0.84337095
60MAP2K40.83239995
61SYK0.82355955
62CAMK40.81892795
63PTK60.81457402
64MAP2K20.81375746
65MAPK150.79434876
66FGFR30.77082040
67TAOK20.74651092
68PRKCH0.74318190
69PINK10.72969013
70SGK2230.72511963
71SGK4940.72511963
72CCNB10.72242437
73MAPK120.72240287
74TBK10.71270270
75STK160.69522869
76WNK10.68755986
77LCK0.66170334
78PASK0.65036143
79JAK20.64571175
80ITK0.63778154
81TTK0.63333921
82TESK20.61825719
83TXK0.61810690
84CHEK20.60402941
85IRAK30.59891809
86STK38L0.58579904
87CAMK10.58465990
88MUSK0.58389083
89IKBKE0.57625557
90CDK40.57260241
91STK30.56715763
92UHMK10.56165212
93SGK20.55464591
94MAP3K140.54360922
95MAP3K100.53045436
96NTRK20.52626060
97MAP3K30.52208812
98PRKAA20.51541295
99IRAK20.49335362
100RET0.49232119
101PKN20.48751073
102MAPK110.48470946
103SGK10.47571290
104AKT30.47100768
105PRKCG0.47016919
106PAK10.41544680
107MAP2K60.40691137
108LMTK20.37971362
109PAK40.37925830
110MAPKAPK50.35626063
111BRAF0.34522288
112BRSK20.33343064
113CHEK10.31189975
114BRSK10.28061563
115PRKCZ0.27927957
116MARK20.27349748
117CAMKK10.26060420
118CDK150.25447587
119PAK20.22566486
120CDK180.22173559
121CDK11A0.21000205
122PRKCQ0.20167195
123ATM0.19996139
124WEE10.18642829
125MTOR0.18267527
126PRKG20.17622410
127STK100.16923680
128PRKAA10.16486656
129CDK140.16300358
130CAMK1G0.14845902
131ATR0.14681126
132RPS6KA10.13492343
133MARK30.13125507
134BUB10.12617848
135RPS6KB10.10671296
136PLK10.10075036
137AURKA0.09930566
138CSNK2A10.09686464
139PRKCD0.09560825
140PIM10.09123167
141CSF1R0.08503188
142GSK3B0.05288502
143CLK10.04441998
144STK110.04307617
145NEK60.03894218
146CAMK2A0.03591275
147ZAP700.03182542
148PRKACG0.03062833
149MAPK80.03004530
150CDK60.02984639
151PRKCA0.02489056
152TRIB30.01595736
153PRKCB0.01485815
154PLK40.01102338
155CSNK2A20.00883468
156CDK10.00568712
157CDK20.00465812
158PRKG10.00236306
159IGF1R-0.0655559
160PRKACB-0.0584682
161MAP3K5-0.0512233
162MAP3K4-0.0496382
163PAK6-0.0487442
164RPS6KA3-0.0461194
165PRKACA-0.0426312
166PDGFRB-0.0351940
167CDC7-0.0348584
168MAP3K1-0.0210223
169EGFR-0.0202758
170PKN1-0.0056874

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.01062357
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43010958
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.58814767
4Linoleic acid metabolism_Homo sapiens_hsa005913.50858304
5Vitamin B6 metabolism_Homo sapiens_hsa007503.16419814
6Pyruvate metabolism_Homo sapiens_hsa006203.10760673
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.95991475
8Acute myeloid leukemia_Homo sapiens_hsa052212.52407025
9Glucagon signaling pathway_Homo sapiens_hsa049222.48301698
10Other glycan degradation_Homo sapiens_hsa005112.44348226
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40040211
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.24779887
13Propanoate metabolism_Homo sapiens_hsa006402.23714566
14Notch signaling pathway_Homo sapiens_hsa043302.12726716
15Basal transcription factors_Homo sapiens_hsa030222.12030162
16Osteoclast differentiation_Homo sapiens_hsa043802.07385903
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06974797
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02733929
19Non-small cell lung cancer_Homo sapiens_hsa052231.94345140
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93043539
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.89850093
22Fat digestion and absorption_Homo sapiens_hsa049751.88798536
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.85156110
24Selenocompound metabolism_Homo sapiens_hsa004501.82086429
25Glycerolipid metabolism_Homo sapiens_hsa005611.81651491
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79150632
27PPAR signaling pathway_Homo sapiens_hsa033201.78666871
28T cell receptor signaling pathway_Homo sapiens_hsa046601.76768398
29Chronic myeloid leukemia_Homo sapiens_hsa052201.76745253
30Ether lipid metabolism_Homo sapiens_hsa005651.68763050
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65970401
32Fructose and mannose metabolism_Homo sapiens_hsa000511.63546945
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58895313
34Pentose phosphate pathway_Homo sapiens_hsa000301.57955074
35Amphetamine addiction_Homo sapiens_hsa050311.57486507
36Mineral absorption_Homo sapiens_hsa049781.56294326
37Fatty acid degradation_Homo sapiens_hsa000711.52575796
38Leishmaniasis_Homo sapiens_hsa051401.49548220
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46455111
40Fatty acid metabolism_Homo sapiens_hsa012121.45604267
41Cardiac muscle contraction_Homo sapiens_hsa042601.43853090
42Oocyte meiosis_Homo sapiens_hsa041141.41541400
43Prolactin signaling pathway_Homo sapiens_hsa049171.40380538
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.38249938
45mTOR signaling pathway_Homo sapiens_hsa041501.37295339
46Choline metabolism in cancer_Homo sapiens_hsa052311.37146158
47Carbon metabolism_Homo sapiens_hsa012001.36718593
48Primary immunodeficiency_Homo sapiens_hsa053401.35664480
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33803700
50Pancreatic cancer_Homo sapiens_hsa052121.33177259
51ErbB signaling pathway_Homo sapiens_hsa040121.29857394
52Glutathione metabolism_Homo sapiens_hsa004801.28165501
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.27254064
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.26696401
55Endometrial cancer_Homo sapiens_hsa052131.25889526
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25607190
57FoxO signaling pathway_Homo sapiens_hsa040681.23294134
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22054667
59Influenza A_Homo sapiens_hsa051641.18124258
60Collecting duct acid secretion_Homo sapiens_hsa049661.16721094
61Chemokine signaling pathway_Homo sapiens_hsa040621.16464003
62Staphylococcus aureus infection_Homo sapiens_hsa051501.14877909
63Hepatitis B_Homo sapiens_hsa051611.14714844
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10521577
65Renal cell carcinoma_Homo sapiens_hsa052111.07639039
66Insulin signaling pathway_Homo sapiens_hsa049101.06666556
67Tuberculosis_Homo sapiens_hsa051521.06440782
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.06372469
69Hedgehog signaling pathway_Homo sapiens_hsa043401.06236668
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05796960
71Type II diabetes mellitus_Homo sapiens_hsa049301.04732337
72MAPK signaling pathway_Homo sapiens_hsa040101.04075424
73Arachidonic acid metabolism_Homo sapiens_hsa005901.04066495
74Jak-STAT signaling pathway_Homo sapiens_hsa046301.03976577
75Insulin resistance_Homo sapiens_hsa049311.03489611
76Colorectal cancer_Homo sapiens_hsa052101.03205939
77NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02810954
78Herpes simplex infection_Homo sapiens_hsa051681.02697112
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01169401
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.99877884
81Antigen processing and presentation_Homo sapiens_hsa046120.99447860
82Measles_Homo sapiens_hsa051620.98390557
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98085532
84Purine metabolism_Homo sapiens_hsa002300.96273702
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94365227
86Toxoplasmosis_Homo sapiens_hsa051450.94010040
87Renin secretion_Homo sapiens_hsa049240.92557960
88TNF signaling pathway_Homo sapiens_hsa046680.91629859
89GnRH signaling pathway_Homo sapiens_hsa049120.91120635
90Dorso-ventral axis formation_Homo sapiens_hsa043200.90791261
91Chemical carcinogenesis_Homo sapiens_hsa052040.90581383
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90240253
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.89900324
94Systemic lupus erythematosus_Homo sapiens_hsa053220.89142649
95Biosynthesis of amino acids_Homo sapiens_hsa012300.87993013
96Insulin secretion_Homo sapiens_hsa049110.86256853
97Hepatitis C_Homo sapiens_hsa051600.86041505
98Graft-versus-host disease_Homo sapiens_hsa053320.84868939
99Glioma_Homo sapiens_hsa052140.83013996
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82658037
101Allograft rejection_Homo sapiens_hsa053300.82266417
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82201716
103Autoimmune thyroid disease_Homo sapiens_hsa053200.82051539
104Thyroid hormone synthesis_Homo sapiens_hsa049180.81626578
105Bladder cancer_Homo sapiens_hsa052190.77495822
106Long-term potentiation_Homo sapiens_hsa047200.77383125
107Malaria_Homo sapiens_hsa051440.77352819
108Bile secretion_Homo sapiens_hsa049760.76929165
109Huntingtons disease_Homo sapiens_hsa050160.73823532
110Estrogen signaling pathway_Homo sapiens_hsa049150.72287721
111Fanconi anemia pathway_Homo sapiens_hsa034600.70797354
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68874931
113Prostate cancer_Homo sapiens_hsa052150.67207084
114mRNA surveillance pathway_Homo sapiens_hsa030150.66332221
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.65453148
116Platelet activation_Homo sapiens_hsa046110.64314751
117Lysine degradation_Homo sapiens_hsa003100.63182755
118Hematopoietic cell lineage_Homo sapiens_hsa046400.62486606
119Cholinergic synapse_Homo sapiens_hsa047250.61942731
120Pancreatic secretion_Homo sapiens_hsa049720.61656202
121Apoptosis_Homo sapiens_hsa042100.61393537
122Renin-angiotensin system_Homo sapiens_hsa046140.61228659
123HTLV-I infection_Homo sapiens_hsa051660.59821476
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.59741038
125Epstein-Barr virus infection_Homo sapiens_hsa051690.59004272
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58036015
127Viral myocarditis_Homo sapiens_hsa054160.57479033
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.57349457
129Thyroid cancer_Homo sapiens_hsa052160.57346590
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56934291
131Synaptic vesicle cycle_Homo sapiens_hsa047210.55938867
132Prion diseases_Homo sapiens_hsa050200.55747599
133Legionellosis_Homo sapiens_hsa051340.54309084
134Salivary secretion_Homo sapiens_hsa049700.53509176
135Alcoholism_Homo sapiens_hsa050340.53120682
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51797779
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49545552
138African trypanosomiasis_Homo sapiens_hsa051430.45377985
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.45315415
140RNA transport_Homo sapiens_hsa030130.44692106
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44547896
142Sulfur metabolism_Homo sapiens_hsa009200.43383814
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42690247
144Endocytosis_Homo sapiens_hsa041440.42106298
145AMPK signaling pathway_Homo sapiens_hsa041520.40572201
146Calcium signaling pathway_Homo sapiens_hsa040200.39571138
147ABC transporters_Homo sapiens_hsa020100.39411784
148Type I diabetes mellitus_Homo sapiens_hsa049400.39298635
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39004220
150Metabolic pathways_Homo sapiens_hsa011000.38887897
151Gastric acid secretion_Homo sapiens_hsa049710.38601689
152Regulation of autophagy_Homo sapiens_hsa041400.38500663
153Protein digestion and absorption_Homo sapiens_hsa049740.38492988
154Pyrimidine metabolism_Homo sapiens_hsa002400.37624706
155Ras signaling pathway_Homo sapiens_hsa040140.37497043
156Olfactory transduction_Homo sapiens_hsa047400.37223550
157VEGF signaling pathway_Homo sapiens_hsa043700.36943174
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32969924
159Cocaine addiction_Homo sapiens_hsa050300.26841396
160Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24728015
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24489006
162cAMP signaling pathway_Homo sapiens_hsa040240.24462089
163Inositol phosphate metabolism_Homo sapiens_hsa005620.20685094
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20363108
165HIF-1 signaling pathway_Homo sapiens_hsa040660.15939645
166Salmonella infection_Homo sapiens_hsa051320.13243930
167Sulfur relay system_Homo sapiens_hsa041220.13032242
168Circadian entrainment_Homo sapiens_hsa047130.11822633
169Taste transduction_Homo sapiens_hsa047420.10376951
170Wnt signaling pathway_Homo sapiens_hsa043100.10085887
171B cell receptor signaling pathway_Homo sapiens_hsa046620.09564083
172Basal cell carcinoma_Homo sapiens_hsa052170.08873168
173Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07539760
174DNA replication_Homo sapiens_hsa030300.06241087
175Viral carcinogenesis_Homo sapiens_hsa052030.05849258

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