FAM231D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.83234575
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.67900448
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58180024
4negative regulation of cell killing (GO:0031342)5.58180024
5regulation of B cell receptor signaling pathway (GO:0050855)5.49544463
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99015851
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.88736569
8antigen processing and presentation of endogenous antigen (GO:0019883)4.69859520
9cellular response to interleukin-15 (GO:0071350)4.57667682
10response to interleukin-15 (GO:0070672)4.54668977
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52743594
12regulation of gamma-delta T cell activation (GO:0046643)4.50908473
13activated T cell proliferation (GO:0050798)4.44996686
14regulation of gamma-delta T cell differentiation (GO:0045586)4.37403214
15negative T cell selection (GO:0043383)4.21614433
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.20135984
17modulation by symbiont of host defense response (GO:0052031)4.13759875
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13759875
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13759875
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.13759875
21modulation by symbiont of host immune response (GO:0052553)4.13759875
22positive regulation by symbiont of host defense response (GO:0052509)4.13759875
23negative thymic T cell selection (GO:0045060)3.97296407
24leukocyte aggregation (GO:0070486)3.84049969
25cilium or flagellum-dependent cell motility (GO:0001539)3.82649955
26neutrophil activation involved in immune response (GO:0002283)3.77795659
27negative regulation of T cell mediated immunity (GO:0002710)3.76621440
28positive regulation of granulocyte differentiation (GO:0030854)3.73828988
29macrophage activation involved in immune response (GO:0002281)3.72672635
30detection of other organism (GO:0098543)3.68161905
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66011349
32B cell receptor signaling pathway (GO:0050853)3.63997072
33neutrophil activation (GO:0042119)3.63457787
34detection of bacterium (GO:0016045)3.59142735
35negative regulation of leukocyte mediated immunity (GO:0002704)3.56741444
36positive T cell selection (GO:0043368)3.52910060
37T cell selection (GO:0045058)3.43379020
38regulation of interferon-beta biosynthetic process (GO:0045357)3.39149748
39cellular extravasation (GO:0045123)3.33490377
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31926321
41negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.28033105
42T cell migration (GO:0072678)3.27813794
43regulation of alpha-beta T cell proliferation (GO:0046640)3.27625124
44microglial cell activation (GO:0001774)3.21533475
45regulation of T cell mediated cytotoxicity (GO:0001914)3.14744275
46positive thymic T cell selection (GO:0045059)3.12209030
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11990149
48tolerance induction (GO:0002507)3.11197892
49regulation of B cell differentiation (GO:0045577)3.09478911
50negative regulation of interleukin-12 production (GO:0032695)3.08998414
51granulocyte activation (GO:0036230)3.08932435
52response to type I interferon (GO:0034340)3.08142140
53myeloid cell activation involved in immune response (GO:0002275)3.07628825
54negative regulation of T-helper cell differentiation (GO:0045623)3.05527913
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05527913
56type I interferon signaling pathway (GO:0060337)3.02380866
57cellular response to type I interferon (GO:0071357)3.02380866
58negative regulation of B cell mediated immunity (GO:0002713)3.02353460
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.02353460
60detection of external biotic stimulus (GO:0098581)3.02053540
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99343355
62neutrophil mediated immunity (GO:0002446)2.97777236
63negative regulation of adaptive immune response (GO:0002820)2.97582687
64mast cell activation (GO:0045576)2.97348053
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97294193
66response to host immune response (GO:0052572)2.97294193
67thymic T cell selection (GO:0045061)2.95507905
68regulation of natural killer cell mediated immunity (GO:0002715)2.91373239
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91373239
70regulation of regulatory T cell differentiation (GO:0045589)2.89465842
71regulation of tolerance induction (GO:0002643)2.88695469
72regulation of T cell tolerance induction (GO:0002664)2.88285289
73positive regulation of B cell differentiation (GO:0045579)2.84780626
74regulation of mast cell activation (GO:0033003)2.84563505
75leukocyte degranulation (GO:0043299)2.84176734
76detection of molecule of bacterial origin (GO:0032490)2.80890799
77antigen receptor-mediated signaling pathway (GO:0050851)2.80450203
78myeloid leukocyte mediated immunity (GO:0002444)2.80403224
79regulation of mast cell activation involved in immune response (GO:0033006)2.78583038
80response to peptidoglycan (GO:0032494)2.77782425
81interferon-gamma production (GO:0032609)2.75990372
82defense response to protozoan (GO:0042832)2.74412582
83regulation of mast cell degranulation (GO:0043304)2.74057540
84negative regulation of alpha-beta T cell activation (GO:0046636)2.73528092
85positive regulation of tolerance induction (GO:0002645)2.73472112
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71145112
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71112998
88establishment of protein localization to Golgi (GO:0072600)2.70931224
89mast cell degranulation (GO:0043303)2.70325959
90mast cell activation involved in immune response (GO:0002279)2.70325959
91respiratory burst (GO:0045730)2.70174045
92dendritic cell migration (GO:0036336)2.67704346
93regulation of granulocyte differentiation (GO:0030852)2.67645806
94T cell homeostasis (GO:0043029)2.67184021
95macrophage activation (GO:0042116)2.67140724
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.65812243
97regulation of necroptotic process (GO:0060544)2.65791878
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64382924
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63935596
100response to host defenses (GO:0052200)2.63935596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.84330315
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33299898
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.67269455
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.38974938
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.04202300
6RUNX_20019798_ChIP-Seq_JUKART_Human2.97967633
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91754160
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49441681
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46388642
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38462263
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.29460445
12MYB_26560356_Chip-Seq_TH2_Human2.29273244
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.13346619
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96336599
15SCL_19346495_ChIP-Seq_HPC-7_Human1.94974698
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94085415
17SPI1_23127762_ChIP-Seq_K562_Human1.90085096
18GATA3_27048872_Chip-Seq_THYMUS_Human1.88312421
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84384852
20VDR_24787735_ChIP-Seq_THP-1_Human1.72707187
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72499477
22MYB_26560356_Chip-Seq_TH1_Human1.71494794
23GATA3_26560356_Chip-Seq_TH2_Human1.63717168
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63094522
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61406488
26SPI1_23547873_ChIP-Seq_NB4_Human1.58980428
27ER_23166858_ChIP-Seq_MCF-7_Human1.53759142
28VDR_24763502_ChIP-Seq_THP-1_Human1.50181930
29UTX_26944678_Chip-Seq_JUKART_Human1.48140514
30DROSHA_22980978_ChIP-Seq_HELA_Human1.47366883
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47127589
32MAF_26560356_Chip-Seq_TH1_Human1.46910907
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46466537
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.44452925
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44290442
36GBX2_23144817_ChIP-Seq_PC3_Human1.42171309
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37395445
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32624885
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32502614
40MAF_26560356_Chip-Seq_TH2_Human1.32234757
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31131259
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27882505
43PRDM14_20953172_ChIP-Seq_ESCs_Human1.27746713
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23816868
45IGF1R_20145208_ChIP-Seq_DFB_Human1.21441216
46SMRT_27268052_Chip-Seq_Bcells_Human1.20051516
47AR_21572438_ChIP-Seq_LNCaP_Human1.17145960
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16351818
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15818953
50ZNF274_21170338_ChIP-Seq_K562_Hela1.11363132
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10745878
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08832916
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08637624
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08497797
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08058842
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04542614
57EZH2_22144423_ChIP-Seq_EOC_Human1.04318532
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01175127
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01175127
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.00769508
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98899271
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97986070
63GATA1_19941827_ChIP-Seq_MEL_Mouse0.97610457
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97315683
65VDR_21846776_ChIP-Seq_THP-1_Human0.96856841
66GATA2_21666600_ChIP-Seq_HMVEC_Human0.96647110
67FLI1_27457419_Chip-Seq_LIVER_Mouse0.95976890
68NOTCH1_21737748_ChIP-Seq_TLL_Human0.95576337
69VDR_22108803_ChIP-Seq_LS180_Human0.94809289
70TAF15_26573619_Chip-Seq_HEK293_Human0.94653632
71STAT3_23295773_ChIP-Seq_U87_Human0.94531887
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93944177
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92632385
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92373812
75BCAT_22108803_ChIP-Seq_LS180_Human0.90931961
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.90378623
77GATA3_26560356_Chip-Seq_TH1_Human0.90273466
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90088103
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89747492
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89587997
81ESR1_20079471_ChIP-ChIP_T-47D_Human0.87934157
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87862268
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86398534
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86178830
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85991079
86CBP_20019798_ChIP-Seq_JUKART_Human0.85991079
87MYC_22102868_ChIP-Seq_BL_Human0.85686301
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85116021
89KDM2B_26808549_Chip-Seq_DND41_Human0.83589023
90GATA1_22025678_ChIP-Seq_K562_Human0.83497177
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83427452
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82532188
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81219580
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.81104141
95OCT4_20526341_ChIP-Seq_ESCs_Human0.80298001
96RXR_22108803_ChIP-Seq_LS180_Human0.80187141
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79688482
98AR_25329375_ChIP-Seq_VCAP_Human0.79410555
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78742358
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78697017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.42786873
2MP0001835_abnormal_antigen_presentation3.33767096
3MP0005671_abnormal_response_to3.32758480
4MP0003436_decreased_susceptibility_to3.12465895
5MP0003763_abnormal_thymus_physiology3.09426707
6MP0001986_abnormal_taste_sensitivity3.00659700
7MP0001800_abnormal_humoral_immune2.97234644
8MP0005387_immune_system_phenotype2.73375797
9MP0001790_abnormal_immune_system2.73375797
10MP0003303_peritoneal_inflammation2.66898603
11MP0002419_abnormal_innate_immunity2.55622144
12MP0000685_abnormal_immune_system2.52534442
13MP0005025_abnormal_response_to2.51509642
14MP0009785_altered_susceptibility_to2.51259657
15MP0002723_abnormal_immune_serum2.50838000
16MP0005000_abnormal_immune_tolerance2.47731803
17MP0002420_abnormal_adaptive_immunity2.42997193
18MP0001819_abnormal_immune_cell2.39625417
19MP0006082_CNS_inflammation2.34142004
20MP0002452_abnormal_antigen_presenting2.29421046
21MP0003866_abnormal_defecation2.03342743
22MP0002405_respiratory_system_inflammati1.98479732
23MP0000569_abnormal_digit_pigmentation1.88572884
24MP0002398_abnormal_bone_marrow1.86207976
25MP0000716_abnormal_immune_system1.85551620
26MP0002132_abnormal_respiratory_system1.84545132
27MP0004381_abnormal_hair_follicle1.83224078
28MP0002148_abnormal_hypersensitivity_rea1.76194992
29MP0005310_abnormal_salivary_gland1.75656172
30MP0010155_abnormal_intestine_physiology1.66058376
31MP0003172_abnormal_lysosome_physiology1.64906254
32MP0003300_gastrointestinal_ulcer1.64458669
33MP0000689_abnormal_spleen_morphology1.64216449
34MP0002722_abnormal_immune_system1.62664250
35MP0002138_abnormal_hepatobiliary_system1.60732776
36MP0000703_abnormal_thymus_morphology1.60276179
37MP0001873_stomach_inflammation1.54895412
38MP0001845_abnormal_inflammatory_respons1.51967850
39MP0000465_gastrointestinal_hemorrhage1.46945702
40MP0001533_abnormal_skeleton_physiology1.45964233
41MP0002396_abnormal_hematopoietic_system1.43003673
42MP0001968_abnormal_touch/_nociception1.39948949
43MP0005075_abnormal_melanosome_morpholog1.37191038
44MP0001501_abnormal_sleep_pattern1.36729721
45MP0005410_abnormal_fertilization1.33937652
46MP0002429_abnormal_blood_cell1.33750555
47MP0005464_abnormal_platelet_physiology1.31088873
48MP0003183_abnormal_peptide_metabolism1.30396518
49MP0002277_abnormal_respiratory_mucosa1.28953417
50MP0003045_fibrosis1.27854083
51MP0009333_abnormal_splenocyte_physiolog1.25464082
52MP0008469_abnormal_protein_level1.17375867
53MP0009764_decreased_sensitivity_to1.17332858
54MP0003787_abnormal_imprinting1.17295997
55MP0002928_abnormal_bile_duct1.17077738
56MP0004883_abnormal_blood_vessel1.12841219
57MP0009278_abnormal_bone_marrow1.08893217
58MP0008260_abnormal_autophagy1.05448997
59MP0001851_eye_inflammation0.98490469
60MP0003828_pulmonary_edema0.95722480
61MP0002693_abnormal_pancreas_physiology0.95593714
62MP0005174_abnormal_tail_pigmentation0.94182707
63MP0004947_skin_inflammation0.93142315
64MP0000427_abnormal_hair_cycle0.91764706
65MP0002933_joint_inflammation0.91210473
66MP0001545_abnormal_hematopoietic_system0.90576361
67MP0005397_hematopoietic_system_phenotyp0.90576361
68MP0005083_abnormal_biliary_tract0.88190255
69MP0000015_abnormal_ear_pigmentation0.86889554
70MP0003690_abnormal_glial_cell0.85488356
71MP0002653_abnormal_ependyma_morphology0.85474920
72MP0002735_abnormal_chemical_nociception0.84449650
73MP0004510_myositis0.79603916
74MP0005164_abnormal_response_to0.77884502
75MP0002166_altered_tumor_susceptibility0.77754549
76MP0002998_abnormal_bone_remodeling0.72881410
77MP0005084_abnormal_gallbladder_morpholo0.72838257
78MP0005377_hearing/vestibular/ear_phenot0.72291119
79MP0003878_abnormal_ear_physiology0.72291119
80MP0003252_abnormal_bile_duct0.69457341
81MP0001663_abnormal_digestive_system0.67946187
82MP0004484_altered_response_of0.64679405
83MP0002733_abnormal_thermal_nociception0.64309978
84MP0002822_catalepsy0.63981628
85MP0009115_abnormal_fat_cell0.63562903
86MP0000604_amyloidosis0.62786052
87MP0008874_decreased_physiological_sensi0.61983374
88MP0005376_homeostasis/metabolism_phenot0.60624729
89MP0001486_abnormal_startle_reflex0.60091809
90MP0001664_abnormal_digestion0.58842684
91MP0003698_abnormal_male_reproductive0.58720963
92MP0004130_abnormal_muscle_cell0.58561817
93MP0003656_abnormal_erythrocyte_physiolo0.57542810
94MP0002332_abnormal_exercise_endurance0.57030299
95MP0000470_abnormal_stomach_morphology0.56694621
96MP0005334_abnormal_fat_pad0.55599438
97MP0005535_abnormal_body_temperature0.55251207
98MP0001970_abnormal_pain_threshold0.54857628
99MP0002168_other_aberrant_phenotype0.54486234
100MP0005166_decreased_susceptibility_to0.54257756

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.27493059
2Myositis (HP:0100614)4.95074995
3Elevated erythrocyte sedimentation rate (HP:0003565)4.63331299
4Retrobulbar optic neuritis (HP:0100654)4.43830725
5Optic neuritis (HP:0100653)4.43830725
6Orchitis (HP:0100796)4.41206743
7Eczematoid dermatitis (HP:0000976)4.36452277
8Recurrent abscess formation (HP:0002722)4.34742972
9Recurrent bacterial skin infections (HP:0005406)4.23351739
10Hypochromic microcytic anemia (HP:0004840)4.18797992
11T lymphocytopenia (HP:0005403)4.09368111
12Abnormality of T cell number (HP:0011839)4.00208905
13Recurrent fungal infections (HP:0002841)3.96403088
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.89673373
15Recurrent cutaneous fungal infections (HP:0011370)3.80118445
16Chronic mucocutaneous candidiasis (HP:0002728)3.80118445
17Abnormality of macrophages (HP:0004311)3.54979771
18Chronic otitis media (HP:0000389)3.51420233
19Encephalitis (HP:0002383)3.49532131
20Recurrent skin infections (HP:0001581)3.42482792
21Hypochromic anemia (HP:0001931)3.30074294
22Gastrointestinal infarctions (HP:0005244)3.18006415
23Abnormality of T cells (HP:0002843)3.15889410
24Keratoconjunctivitis sicca (HP:0001097)3.15497030
25Keratoconjunctivitis (HP:0001096)3.14474886
26Mediastinal lymphadenopathy (HP:0100721)3.12477473
27Meningitis (HP:0001287)3.11407019
28Recurrent gram-negative bacterial infections (HP:0005420)3.10562375
29Hyperventilation (HP:0002883)3.00304589
30Vasculitis (HP:0002633)2.99785244
31Panhypogammaglobulinemia (HP:0003139)2.92350743
32Spontaneous hematomas (HP:0007420)2.86725055
33Prolonged bleeding time (HP:0003010)2.77531576
34Chronic sinusitis (HP:0011109)2.73271440
35Hemoptysis (HP:0002105)2.72606766
36Pustule (HP:0200039)2.68799008
37Gingivitis (HP:0000230)2.68743225
38Obstructive lung disease (HP:0006536)2.66358525
39Chronic obstructive pulmonary disease (HP:0006510)2.66358525
40Protruding tongue (HP:0010808)2.63558158
41Recurrent sinusitis (HP:0011108)2.58114864
42Recurrent bronchitis (HP:0002837)2.57897849
43Leukocytosis (HP:0001974)2.51990580
44Inflammation of the large intestine (HP:0002037)2.50774564
45Chest pain (HP:0100749)2.50184216
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48998876
47Clumsiness (HP:0002312)2.46743736
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46128797
49Papilledema (HP:0001085)2.44291022
50Pulmonary infiltrates (HP:0002113)2.41704497
51Recurrent viral infections (HP:0004429)2.36521611
52Abnormality of T cell physiology (HP:0011840)2.35060463
53Episodic fever (HP:0001954)2.34785044
54Stomach cancer (HP:0012126)2.34300183
55Pulmonary embolism (HP:0002204)2.31811015
56Gastrointestinal inflammation (HP:0004386)2.29581460
57Microcytic anemia (HP:0001935)2.26554907
58Lymphopenia (HP:0001888)2.24528039
59Eosinophilia (HP:0001880)2.23288029
60Acute hepatic failure (HP:0006554)2.23248415
61Autoimmune hemolytic anemia (HP:0001890)2.23011988
62Granulocytopenia (HP:0001913)2.22102556
63Abnormality of eosinophils (HP:0001879)2.19402209
64Attenuation of retinal blood vessels (HP:0007843)2.17907078
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15047243
66Absent speech (HP:0001344)2.13922230
67Progressive cerebellar ataxia (HP:0002073)2.13887194
68Increased IgE level (HP:0003212)2.13646378
69Abnormal respiratory motile cilium morphology (HP:0005938)2.13094432
70Abnormal respiratory epithelium morphology (HP:0012253)2.13094432
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.12660464
72Epistaxis (HP:0000421)2.12561959
73Absent/shortened dynein arms (HP:0200106)2.12125960
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.12125960
75Urticaria (HP:0001025)2.11851935
76IgG deficiency (HP:0004315)2.08576860
77Anorexia (HP:0002039)2.07682574
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.07185234
79Arterial thrombosis (HP:0004420)2.04981345
80Widely spaced teeth (HP:0000687)2.04534662
81Abnormal rod and cone electroretinograms (HP:0008323)2.03488134
82Hypoplasia of the thymus (HP:0000778)2.02646997
83Severe combined immunodeficiency (HP:0004430)2.01729067
84Gingival bleeding (HP:0000225)2.00907758
85Genetic anticipation (HP:0003743)1.98702654
86Abnormality of B cell number (HP:0010975)1.97105164
87Abnormality of the pleura (HP:0002103)1.90803640
88Diplopia (HP:0000651)1.90213499
89Abnormality of binocular vision (HP:0011514)1.90213499
90Colitis (HP:0002583)1.89912132
91Increased cerebral lipofuscin (HP:0011813)1.89883782
92Increased IgM level (HP:0003496)1.89682442
93Postural instability (HP:0002172)1.87919481
94Increased density of long bones (HP:0006392)1.86601207
95Hemiplegia (HP:0002301)1.85553397
96Autoimmune thrombocytopenia (HP:0001973)1.85089789
97Pancreatic cysts (HP:0001737)1.82434448
98IgM deficiency (HP:0002850)1.79499268
99Keratitis (HP:0000491)1.78812921
100Gangrene (HP:0100758)1.77242464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.28908788
2MAP4K14.06047910
3FRK3.73959909
4FES2.70396239
5TNK22.60410657
6BLK2.26330349
7TXK2.23358921
8TAOK32.09699726
9GRK62.04019481
10CSK2.00618912
11TYK21.98259562
12BTK1.80526373
13MARK31.78992638
14IRAK41.72426078
15SIK21.69562472
16SYK1.66345225
17ZAP701.65940592
18TAOK11.58787437
19PINK11.55601947
20HCK1.55392212
21ERN11.48030754
22ITK1.47665747
23TEC1.42461057
24EPHB11.40583658
25KIT1.40542340
26IKBKE1.40239324
27CAMKK21.38323423
28NLK1.37246528
29MAP2K31.37199408
30INSRR1.31784975
31STK381.30455023
32CASK1.28775281
33LYN1.26542784
34JAK11.25731040
35SIK31.24634557
36MAPK131.23807503
37JAK31.21423926
38LCK1.21346217
39MAP4K21.13453558
40CSF1R1.10067632
41FGR1.08879472
42PDK11.06631663
43SGK21.06624675
44PIK3CG1.04127291
45JAK21.00651641
46PRKCQ1.00407056
47PTK2B1.00186899
48TESK20.99273968
49MAP3K140.95650351
50MAP3K30.95391248
51IKBKB0.93858866
52MAP3K110.93078666
53DAPK20.92465289
54MAP3K70.92061296
55MAP3K10.91249232
56YES10.91163841
57PRKD20.90161592
58MAP3K130.87967564
59MARK20.86307234
60ACVR1B0.86164169
61ADRBK20.81940732
62KSR20.79513923
63TBK10.74540374
64HIPK20.74286319
65IRAK10.73937992
66CAMKK10.71026294
67PRPF4B0.71001538
68SGK2230.68511292
69SGK4940.68511292
70PDPK10.65840730
71SGK30.64864035
72TGFBR20.64705406
73MAP3K20.64426686
74PRKCH0.61747662
75GRK70.60911572
76MATK0.59551064
77STK110.57938247
78MAPK150.54456780
79STK100.51067340
80GRK10.50862938
81MAPK120.50241560
82ADRBK10.48582225
83MAPK70.48568327
84FGFR30.46301208
85MAP2K60.45660600
86CAMK40.44462419
87FYN0.44304957
88BMPR1B0.43944426
89RPS6KA60.39892684
90PRKD30.39434853
91TNIK0.39053101
92MELK0.38330536
93RAF10.33903144
94CDK190.30823190
95PIM10.30600554
96NTRK30.29734246
97KSR10.28602719
98RPS6KC10.28463469
99RPS6KL10.28463469
100PRKCZ0.28309279

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82169103
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46815109
3Graft-versus-host disease_Homo sapiens_hsa053322.38710741
4Osteoclast differentiation_Homo sapiens_hsa043802.17236968
5T cell receptor signaling pathway_Homo sapiens_hsa046602.15815377
6Allograft rejection_Homo sapiens_hsa053302.14684370
7B cell receptor signaling pathway_Homo sapiens_hsa046622.07459491
8Autoimmune thyroid disease_Homo sapiens_hsa053202.05941136
9Leishmaniasis_Homo sapiens_hsa051401.91213839
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82412968
11Type I diabetes mellitus_Homo sapiens_hsa049401.74525244
12Staphylococcus aureus infection_Homo sapiens_hsa051501.73802632
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70518311
14Chemokine signaling pathway_Homo sapiens_hsa040621.62317850
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61943517
16Measles_Homo sapiens_hsa051621.60761271
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60097742
18Acute myeloid leukemia_Homo sapiens_hsa052211.58353487
19Hematopoietic cell lineage_Homo sapiens_hsa046401.55805458
20Dorso-ventral axis formation_Homo sapiens_hsa043201.52877667
21Antigen processing and presentation_Homo sapiens_hsa046121.49822946
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.47494232
23Tuberculosis_Homo sapiens_hsa051521.45017410
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40007090
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.39148061
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.38365886
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34144816
28Platelet activation_Homo sapiens_hsa046111.21263267
29Malaria_Homo sapiens_hsa051441.21127090
30African trypanosomiasis_Homo sapiens_hsa051431.15917474
31Influenza A_Homo sapiens_hsa051641.12715008
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12304095
33TNF signaling pathway_Homo sapiens_hsa046681.10688839
34Herpes simplex infection_Homo sapiens_hsa051681.08494152
35Regulation of autophagy_Homo sapiens_hsa041401.04739834
36Toxoplasmosis_Homo sapiens_hsa051451.02361162
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01092115
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00744672
39Viral myocarditis_Homo sapiens_hsa054160.99519504
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95085798
41Olfactory transduction_Homo sapiens_hsa047400.94467546
42Non-small cell lung cancer_Homo sapiens_hsa052230.93322345
43ABC transporters_Homo sapiens_hsa020100.92540013
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92073768
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90470188
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89207769
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85623158
48Hepatitis B_Homo sapiens_hsa051610.85358704
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85162072
50Choline metabolism in cancer_Homo sapiens_hsa052310.84768730
51Legionellosis_Homo sapiens_hsa051340.82929426
52Prolactin signaling pathway_Homo sapiens_hsa049170.81390004
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.80494669
54Hepatitis C_Homo sapiens_hsa051600.80345496
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78918723
56Asthma_Homo sapiens_hsa053100.74876260
57VEGF signaling pathway_Homo sapiens_hsa043700.74494202
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.74081976
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73802345
60MAPK signaling pathway_Homo sapiens_hsa040100.70783841
61FoxO signaling pathway_Homo sapiens_hsa040680.70750827
62Phototransduction_Homo sapiens_hsa047440.70093016
63Inositol phosphate metabolism_Homo sapiens_hsa005620.69184628
64Morphine addiction_Homo sapiens_hsa050320.68778111
65Estrogen signaling pathway_Homo sapiens_hsa049150.66768619
66Type II diabetes mellitus_Homo sapiens_hsa049300.66445555
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.66304181
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65928272
69mTOR signaling pathway_Homo sapiens_hsa041500.65809197
70Taste transduction_Homo sapiens_hsa047420.65035701
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.64652293
72Phagosome_Homo sapiens_hsa041450.62806338
73Cholinergic synapse_Homo sapiens_hsa047250.62617022
74Apoptosis_Homo sapiens_hsa042100.62332950
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62306696
76Circadian entrainment_Homo sapiens_hsa047130.61330282
77Salivary secretion_Homo sapiens_hsa049700.60924439
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.59821783
79Pancreatic cancer_Homo sapiens_hsa052120.59770745
80Endometrial cancer_Homo sapiens_hsa052130.58964097
81Endocytosis_Homo sapiens_hsa041440.58094039
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.57256036
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57045818
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55619236
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55144209
86Renal cell carcinoma_Homo sapiens_hsa052110.54561614
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53678293
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51971967
89Ras signaling pathway_Homo sapiens_hsa040140.51877792
90Colorectal cancer_Homo sapiens_hsa052100.51230006
91Rheumatoid arthritis_Homo sapiens_hsa053230.50590178
92Long-term potentiation_Homo sapiens_hsa047200.50532026
93Chronic myeloid leukemia_Homo sapiens_hsa052200.50495466
94GnRH signaling pathway_Homo sapiens_hsa049120.50458418
95Calcium signaling pathway_Homo sapiens_hsa040200.50399850
96Linoleic acid metabolism_Homo sapiens_hsa005910.49575281
97Oxytocin signaling pathway_Homo sapiens_hsa049210.49376301
98Insulin resistance_Homo sapiens_hsa049310.48974987
99cAMP signaling pathway_Homo sapiens_hsa040240.48884522
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48481755

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