FAM234A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1basement membrane organization (GO:0071711)4.42630086
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.37203193
3COPI coating of Golgi vesicle (GO:0048205)3.97765075
4Golgi transport vesicle coating (GO:0048200)3.97765075
5proline biosynthetic process (GO:0006561)3.97236305
6epithelial cell-cell adhesion (GO:0090136)3.94023861
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.91743855
8COPII vesicle coating (GO:0048208)3.87121095
9intestinal absorption (GO:0050892)3.84226216
10intestinal cholesterol absorption (GO:0030299)3.69594128
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68559937
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64200618
13L-phenylalanine catabolic process (GO:0006559)3.64200618
14fatty acid beta-oxidation (GO:0006635)3.52896736
15L-phenylalanine metabolic process (GO:0006558)3.51963565
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.51963565
17protein maturation by protein folding (GO:0022417)3.47006195
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43581899
19barbed-end actin filament capping (GO:0051016)3.39916357
20regulation of triglyceride catabolic process (GO:0010896)3.33875706
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.32476370
22convergent extension (GO:0060026)3.29921276
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.28133915
24protein heterotrimerization (GO:0070208)3.26688921
25pentose-phosphate shunt (GO:0006098)3.23827283
26fatty acid oxidation (GO:0019395)3.22975029
27fatty acid catabolic process (GO:0009062)3.22458955
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22028021
29glucose 6-phosphate metabolic process (GO:0051156)3.22002216
30glucose catabolic process (GO:0006007)3.21587542
31endocrine pancreas development (GO:0031018)3.20197600
32lipid oxidation (GO:0034440)3.20104279
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.20061867
34alpha-linolenic acid metabolic process (GO:0036109)3.19478962
35sulfur amino acid catabolic process (GO:0000098)3.14411042
36regulation of cholesterol homeostasis (GO:2000188)3.12332054
37glyoxylate metabolic process (GO:0046487)3.11586120
38protein retention in ER lumen (GO:0006621)3.11377820
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.07164516
40adherens junction assembly (GO:0034333)3.05713599
41actin filament depolymerization (GO:0030042)3.00967941
42cell-cell junction maintenance (GO:0045217)3.00506005
43negative regulation of cell size (GO:0045792)2.99676181
44positive regulation of triglyceride metabolic process (GO:0090208)2.99067659
45desmosome organization (GO:0002934)2.98965668
46positive regulation of triglyceride lipase activity (GO:0061365)2.98638986
47positive regulation of lipoprotein lipase activity (GO:0051006)2.98638986
48regulation of sequestering of triglyceride (GO:0010889)2.96956520
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.96912398
50NADPH regeneration (GO:0006740)2.96530305
51regulation of extracellular matrix disassembly (GO:0010715)2.93954965
52phospholipid efflux (GO:0033700)2.91862704
53atrioventricular valve morphogenesis (GO:0003181)2.90808481
54amino-acid betaine metabolic process (GO:0006577)2.89509434
55peptide hormone processing (GO:0016486)2.89020404
56gluconeogenesis (GO:0006094)2.88661116
57regulation of cholesterol metabolic process (GO:0090181)2.87046298
58peptidyl-proline hydroxylation (GO:0019511)2.85678402
59proline metabolic process (GO:0006560)2.85084096
60semaphorin-plexin signaling pathway (GO:0071526)2.81726754
61monocarboxylic acid catabolic process (GO:0072329)2.81425815
62plasma lipoprotein particle clearance (GO:0034381)2.81142781
63hormone catabolic process (GO:0042447)2.81015748
64carnitine shuttle (GO:0006853)2.80710649
65biotin metabolic process (GO:0006768)2.80314635
66regulation of cholesterol esterification (GO:0010872)2.79818756
67monosaccharide biosynthetic process (GO:0046364)2.79641309
68positive regulation of fatty acid biosynthetic process (GO:0045723)2.78247250
69regulation of cardioblast differentiation (GO:0051890)2.78074388
70low-density lipoprotein particle clearance (GO:0034383)2.77738828
71positive regulation of glycolytic process (GO:0045821)2.77182741
72fatty acid transmembrane transport (GO:1902001)2.76419671
73skin morphogenesis (GO:0043589)2.75953653
74regulation of establishment of planar polarity (GO:0090175)2.75341097
75apoptotic process involved in morphogenesis (GO:0060561)2.74954216
76cholesterol homeostasis (GO:0042632)2.74650180
77triglyceride homeostasis (GO:0070328)2.74553785
78acylglycerol homeostasis (GO:0055090)2.74553785
79amyloid precursor protein catabolic process (GO:0042987)2.74150896
80cell-substrate adherens junction assembly (GO:0007045)2.73011507
81focal adhesion assembly (GO:0048041)2.73011507
82peptidyl-arginine omega-N-methylation (GO:0035247)2.72112562
83carnitine metabolic process (GO:0009437)2.71766256
84peptide catabolic process (GO:0043171)2.71496397
85lysine catabolic process (GO:0006554)2.71397962
86lysine metabolic process (GO:0006553)2.71397962
87reverse cholesterol transport (GO:0043691)2.70818847
88homocysteine metabolic process (GO:0050667)2.70715396
89endodermal cell differentiation (GO:0035987)2.70374668
90sterol homeostasis (GO:0055092)2.69615301
91paraxial mesoderm development (GO:0048339)2.69002354
92lipoprotein metabolic process (GO:0042157)2.68175428
93tricarboxylic acid metabolic process (GO:0072350)2.67467563
94hexose biosynthetic process (GO:0019319)2.66884393
95non-canonical Wnt signaling pathway (GO:0035567)2.66769245
964-hydroxyproline metabolic process (GO:0019471)2.66745201
97endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65305181
98short-chain fatty acid metabolic process (GO:0046459)2.65211815
99peptidyl-glutamic acid carboxylation (GO:0017187)2.65072940
100protein carboxylation (GO:0018214)2.65072940
101regulation of early endosome to late endosome transport (GO:2000641)2.64721009
102cell-substrate junction assembly (GO:0007044)2.64556442
103creatine metabolic process (GO:0006600)2.64275277
104aromatic amino acid family catabolic process (GO:0009074)2.62739294
105virion attachment to host cell (GO:0019062)2.62497978
106adhesion of symbiont to host cell (GO:0044650)2.62497978
107branched-chain amino acid catabolic process (GO:0009083)2.59357452
108plasma lipoprotein particle assembly (GO:0034377)2.59354835
109regulation of triglyceride metabolic process (GO:0090207)2.59309208
110regulation of energy homeostasis (GO:2000505)2.58600676
111cholesterol efflux (GO:0033344)2.58222688
112phospholipid homeostasis (GO:0055091)2.57959757
113UV protection (GO:0009650)2.56900068
114branching involved in salivary gland morphogenesis (GO:0060445)2.56256198
115signal peptide processing (GO:0006465)2.56184477
116vascular endothelial growth factor signaling pathway (GO:0038084)2.56053139
117stress fiber assembly (GO:0043149)2.56000527
118endothelial cell morphogenesis (GO:0001886)2.55869473
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55052268
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52792536
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52792536
122amino-acid betaine transport (GO:0015838)2.52201332
123carnitine transport (GO:0015879)2.52201332
124drug transmembrane transport (GO:0006855)2.52033148
125embryo implantation (GO:0007566)2.50804113
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.50793320
127fatty acid homeostasis (GO:0055089)2.49811819
128adhesion of symbiont to host (GO:0044406)2.49734827
129carnitine transmembrane transport (GO:1902603)2.48995988
130positive regulation of lipid catabolic process (GO:0050996)2.48339858
131protein-lipid complex assembly (GO:0065005)2.48280073
132regulation of cholesterol biosynthetic process (GO:0045540)2.48132323
133very-low-density lipoprotein particle assembly (GO:0034379)2.47895655
134cysteine metabolic process (GO:0006534)2.45510644
135angiotensin maturation (GO:0002003)2.44218936
136type B pancreatic cell proliferation (GO:0044342)2.43004103
137hemidesmosome assembly (GO:0031581)2.42919247
138cochlea morphogenesis (GO:0090103)2.42860056
139branched-chain amino acid metabolic process (GO:0009081)2.42753322
140negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42153431
1412-oxoglutarate metabolic process (GO:0006103)2.42117650
142transcytosis (GO:0045056)2.42012362
143extracellular fibril organization (GO:0043206)2.41785625
144nuclear envelope reassembly (GO:0031468)2.41637216
145mitotic nuclear envelope reassembly (GO:0007084)2.41637216
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.40910553
147positive regulation of triglyceride biosynthetic process (GO:0010867)2.40192439
148response to mercury ion (GO:0046689)2.39547832
149sequestering of metal ion (GO:0051238)2.39537868
150complement activation, alternative pathway (GO:0006957)2.39079325
151aspartate family amino acid catabolic process (GO:0009068)2.38553052
152regulation of cholesterol storage (GO:0010885)2.37628904
153hyaluronan catabolic process (GO:0030214)2.37549682
154NADH metabolic process (GO:0006734)2.37406618
155glutamine family amino acid biosynthetic process (GO:0009084)2.37399879
156regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.36873112
157lipid homeostasis (GO:0055088)2.36586569
158high-density lipoprotein particle remodeling (GO:0034375)2.36439289
159glandular epithelial cell differentiation (GO:0002067)2.35862399
160endothelial cell chemotaxis (GO:0035767)2.35411888
161branching involved in mammary gland duct morphogenesis (GO:0060444)2.33007484
162amyloid precursor protein metabolic process (GO:0042982)2.32477404
163apoptotic cell clearance (GO:0043277)2.31692345
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31194469
165glycolytic process (GO:0006096)2.30907626
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30411017
167maternal placenta development (GO:0001893)2.28228168
168glomerular basement membrane development (GO:0032836)2.28184089
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.27901084
170negative regulation of chondrocyte differentiation (GO:0032331)2.26981502
171L-serine transport (GO:0015825)2.26824307
172establishment of apical/basal cell polarity (GO:0035089)2.25693029
173fructose metabolic process (GO:0006000)2.25372715
174oxaloacetate metabolic process (GO:0006107)2.24892027
175regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.24776938
176activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24072213
177negative regulation of catenin import into nucleus (GO:0035414)2.23936050
178neuron projection extension involved in neuron projection guidance (GO:1902284)2.22901392
179axon extension involved in axon guidance (GO:0048846)2.22901392
180negative regulation of smooth muscle cell migration (GO:0014912)2.22693565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.50448311
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.14267296
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.49782046
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.35836152
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.02731145
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.70175295
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.86224357
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59962939
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.41849359
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.38761365
11CLOCK_20551151_ChIP-Seq_293T_Human2.36548220
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33291038
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.32292475
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32200553
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.32038997
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.27044713
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20956095
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.18985504
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18876267
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08775890
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98922128
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97836875
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96016630
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.88380605
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87215982
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81281425
27GATA4_25053715_ChIP-Seq_YYC3_Human1.80002420
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79391787
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.76700340
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76003957
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.74497987
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71180000
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69536816
34VDR_21846776_ChIP-Seq_THP-1_Human1.63441942
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62727558
36SOX2_20726797_ChIP-Seq_SW620_Human1.61977333
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61736393
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59976475
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57007708
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56344874
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55323910
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54824949
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54581605
44P68_20966046_ChIP-Seq_HELA_Human1.50648073
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.50573681
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49940486
47KDM2B_26808549_Chip-Seq_K562_Human1.49876199
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48719733
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47919644
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.45471091
51RACK7_27058665_Chip-Seq_MCF-7_Human1.43809721
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43188563
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42615641
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40612648
55KDM2B_26808549_Chip-Seq_DND41_Human1.40328554
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39534797
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38463871
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37726859
59CTCF_27219007_Chip-Seq_Bcells_Human1.35861343
60SMC4_20622854_ChIP-Seq_HELA_Human1.34876966
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33882203
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33296907
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31947600
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31856885
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31692097
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30586267
67TP53_22127205_ChIP-Seq_IMR90_Human1.30381197
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29728611
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26473666
70SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25703848
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24979725
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24796304
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24635953
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24182796
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23872784
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.23870672
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.23870672
78CREB1_26743006_Chip-Seq_LNCaP_Human1.23824881
79GATA6_25053715_ChIP-Seq_YYC3_Human1.23353188
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22748650
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22096640
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21131450
83GATA1_22025678_ChIP-Seq_K562_Human1.20937900
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.20692719
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20287565
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18561463
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18441364
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17948914
89LXR_22292898_ChIP-Seq_THP-1_Human1.17934599
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17809925
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17398962
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15888328
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15465645
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14888103
95TCF7_22412390_ChIP-Seq_EML_Mouse1.14528892
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13802560
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.12451786
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11762247
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11387268
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.09841586
101XRN2_22483619_ChIP-Seq_HELA_Human1.09145890
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.09049322
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08912135
104GATA3_24758297_ChIP-Seq_MCF-7_Human1.08908342
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08799349
106ATF3_27146783_Chip-Seq_COLON_Human1.08780931
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08738293
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08640527
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08519505
110CDX2_20551321_ChIP-Seq_CACO-2_Human1.07927345
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.07817188
112SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07467717
113MYC_22102868_ChIP-Seq_BL_Human1.06854394
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.05636000
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.05503180
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05271462
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02552429
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01559582
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01360082
120GATA1_19941826_ChIP-Seq_K562_Human1.01120439
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.00758340
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99151303
123NCOR1_26117541_ChIP-Seq_K562_Human0.99113605
124CJUN_26792858_Chip-Seq_BT549_Human0.98915382
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98792071
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.98684730
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98645468
128FOXP1_21924763_ChIP-Seq_HESCs_Human0.98017020
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96654610
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96654610
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.95635413
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93594693
133TP63_22573176_ChIP-Seq_HFKS_Human0.93588063
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92420011
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92257807
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92150662
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.91699981
138ZNF263_19887448_ChIP-Seq_K562_Human0.89258578
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86958603
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86814325
141BCOR_27268052_Chip-Seq_Bcells_Human0.86410339
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86142135
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85364789
144GATA2_19941826_ChIP-Seq_K562_Human0.83341176
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.82922105
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82303513
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82194444
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.81163472
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81016057
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80893241
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80716708
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79725015
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79654727
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79179335
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79058685
156FOXH1_21741376_ChIP-Seq_ESCs_Human0.78773627
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78437912
158RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77072847
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76490297
160KLF5_25053715_ChIP-Seq_YYC3_Human0.76244048
161NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75914075
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75758120
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74641794
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73875923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.16464806
2MP0005360_urolithiasis3.79151023
3MP0002139_abnormal_hepatobiliary_system3.57885330
4MP0003195_calcinosis3.41550194
5MP0010030_abnormal_orbit_morphology3.24856915
6MP0000751_myopathy3.17638460
7MP0004858_abnormal_nervous_system2.96768742
8MP0004043_abnormal_pH_regulation2.96456943
9MP0003252_abnormal_bile_duct2.84022284
10MP0005058_abnormal_lysosome_morphology2.82542341
11MP0005365_abnormal_bile_salt2.68447672
12MP0002138_abnormal_hepatobiliary_system2.60493664
13MP0005085_abnormal_gallbladder_physiolo2.58458703
14MP0001666_abnormal_nutrient_absorption2.43758483
15MP0003279_aneurysm2.12474631
16MP0002837_dystrophic_cardiac_calcinosis2.07364787
17MP0008875_abnormal_xenobiotic_pharmacok2.04824281
18MP0010329_abnormal_lipoprotein_level2.00512417
19MP0000566_synostosis1.98152150
20MP0003191_abnormal_cellular_cholesterol1.95381407
21MP0009643_abnormal_urine_homeostasis1.92377430
22MP0008438_abnormal_cutaneous_collagen1.88704264
23MP0002877_abnormal_melanocyte_morpholog1.84580680
24MP0005670_abnormal_white_adipose1.83775311
25MP0003806_abnormal_nucleotide_metabolis1.81459372
26MP0005332_abnormal_amino_acid1.80035641
27MP0004019_abnormal_vitamin_homeostasis1.79678252
28MP0008260_abnormal_autophagy1.74460199
29MP0002118_abnormal_lipid_homeostasis1.69179948
30MP0005503_abnormal_tendon_morphology1.68424422
31MP0004233_abnormal_muscle_weight1.65265294
32MP0003283_abnormal_digestive_organ1.61751893
33MP0003705_abnormal_hypodermis_morpholog1.55744843
34MP0005451_abnormal_body_composition1.49370760
35MP0005508_abnormal_skeleton_morphology1.47552589
36MP0000537_abnormal_urethra_morphology1.46075173
37MP0005666_abnormal_adipose_tissue1.45774379
38MP0003183_abnormal_peptide_metabolism1.44930274
39MP0003878_abnormal_ear_physiology1.41203950
40MP0005377_hearing/vestibular/ear_phenot1.41203950
41MP0000462_abnormal_digestive_system1.40830482
42MP0000678_abnormal_parathyroid_gland1.40332642
43MP0002249_abnormal_larynx_morphology1.40012599
44MP0000747_muscle_weakness1.37970997
45MP0004264_abnormal_extraembryonic_tissu1.37773759
46MP0005275_abnormal_skin_tensile1.36749598
47MP0001756_abnormal_urination1.36737638
48MP0000609_abnormal_liver_physiology1.36049595
49MP0003300_gastrointestinal_ulcer1.36025916
50MP0010368_abnormal_lymphatic_system1.33759259
51MP0005501_abnormal_skin_physiology1.32632634
52MP0004185_abnormal_adipocyte_glucose1.31918197
53MP0000013_abnormal_adipose_tissue1.31665962
54MP0004087_abnormal_muscle_fiber1.31127212
55MP0000759_abnormal_skeletal_muscle1.25477637
56MP0005319_abnormal_enzyme/_coenzyme1.24278151
57MP0005409_darkened_coat_color1.23346138
58MP0003942_abnormal_urinary_system1.22443326
59MP0002796_impaired_skin_barrier1.22257569
60MP0004084_abnormal_cardiac_muscle1.20380389
61MP0002909_abnormal_adrenal_gland1.19162141
62MP0004036_abnormal_muscle_relaxation1.18402425
63MP0002089_abnormal_postnatal_growth/wei1.16815423
64MP0005083_abnormal_biliary_tract1.16510429
65MP0005375_adipose_tissue_phenotype1.15042182
66MP0000767_abnormal_smooth_muscle1.14610917
67MP0002060_abnormal_skin_morphology1.14259859
68MP0000534_abnormal_ureter_morphology1.13338577
69MP0010630_abnormal_cardiac_muscle1.12758556
70MP0004130_abnormal_muscle_cell1.12451625
71MP0002693_abnormal_pancreas_physiology1.09936569
72MP0010386_abnormal_urinary_bladder1.08547258
73MP0002078_abnormal_glucose_homeostasis1.07816968
74MP0009384_cardiac_valve_regurgitation1.07294326
75MP0002108_abnormal_muscle_morphology1.07002607
76MP0009780_abnormal_chondrocyte_physiolo1.03419717
77MP0005623_abnormal_meninges_morphology1.02720782
78MP0005220_abnormal_exocrine_pancreas1.01963121
79MP0002269_muscular_atrophy1.01831269
80MP0000538_abnormal_urinary_bladder1.00655143
81MP0000762_abnormal_tongue_morphology0.99828168
82MP0010234_abnormal_vibrissa_follicle0.99600828
83MP0000003_abnormal_adipose_tissue0.99552167
84MP0003941_abnormal_skin_development0.99382890
85MP0001661_extended_life_span0.99182677
86MP0003690_abnormal_glial_cell0.98959859
87MP0001765_abnormal_ion_homeostasis0.98371541
88MP0009672_abnormal_birth_weight0.96290652
89MP0005636_abnormal_mineral_homeostasis0.95863570
90MP0000604_amyloidosis0.95359930
91MP0002971_abnormal_brown_adipose0.95157224
92MP0009379_abnormal_foot_pigmentation0.95131423
93MP0002295_abnormal_pulmonary_circulatio0.93441542
94MP0001944_abnormal_pancreas_morphology0.92905992
95MP0005076_abnormal_cell_differentiation0.92394015
96MP0005330_cardiomyopathy0.92144081
97MP0003172_abnormal_lysosome_physiology0.92110414
98MP0002098_abnormal_vibrissa_morphology0.92102371
99MP0002254_reproductive_system_inflammat0.91978077
100MP0003566_abnormal_cell_adhesion0.91941844
101MP0000733_abnormal_muscle_development0.91610093
102MP0005023_abnormal_wound_healing0.91520573
103MP0002896_abnormal_bone_mineralization0.88945413
104MP0003186_abnormal_redox_activity0.88023045
105MP0003950_abnormal_plasma_membrane0.87912583
106MP0004272_abnormal_basement_membrane0.87352524
107MP0005408_hypopigmentation0.87332454
108MP0000049_abnormal_middle_ear0.86228049
109MP0000230_abnormal_systemic_arterial0.84214229
110MP0002106_abnormal_muscle_physiology0.83528642
111MP0005334_abnormal_fat_pad0.83148898
112MP0005369_muscle_phenotype0.82484018
113MP0005257_abnormal_intraocular_pressure0.82303611
114MP0001299_abnormal_eye_distance/0.81432479
115MP0000749_muscle_degeneration0.81265100
116MP0004947_skin_inflammation0.80434905
117MP0002136_abnormal_kidney_physiology0.80026533
118MP0003385_abnormal_body_wall0.79893730
119MP0000750_abnormal_muscle_regeneration0.79061348
120MP0003123_paternal_imprinting0.77812398
121MP0009278_abnormal_bone_marrow0.77796697
122MP0000579_abnormal_nail_morphology0.77506713
123MP0003091_abnormal_cell_migration0.77179252
124MP0001958_emphysema0.76742972
125MP0004145_abnormal_muscle_electrophysio0.75802454
126MP0006036_abnormal_mitochondrial_physio0.75799180
127MP0001533_abnormal_skeleton_physiology0.74034145
128MP0002932_abnormal_joint_morphology0.73830441
129MP0003329_amyloid_beta_deposits0.73516582
130MP0010678_abnormal_skin_adnexa0.73061836
131MP0006138_congestive_heart_failure0.72790305
132MP0005584_abnormal_enzyme/coenzyme_acti0.72657953
133MP0009642_abnormal_blood_homeostasis0.72509268
134MP0001849_ear_inflammation0.71735710
135MP0002972_abnormal_cardiac_muscle0.71417097
136MP0005171_absent_coat_pigmentation0.71347045
137MP0003115_abnormal_respiratory_system0.71060767
138MP0001243_abnormal_dermal_layer0.70792632
139MP0001614_abnormal_blood_vessel0.70257500
140MP0009053_abnormal_anal_canal0.69158291
141MP0004782_abnormal_surfactant_physiolog0.68939233
142MP0003646_muscle_fatigue0.68748462
143MP0003724_increased_susceptibility_to0.68373063
144MP0003453_abnormal_keratinocyte_physiol0.68249851
145MP0002928_abnormal_bile_duct0.67817222
146MP0005167_abnormal_blood-brain_barrier0.66952490
147MP0000467_abnormal_esophagus_morphology0.66555134
148MP0008932_abnormal_embryonic_tissue0.66203602
149MP0005448_abnormal_energy_balance0.66193251
150MP0002116_abnormal_craniofacial_bone0.65116300
151MP0001542_abnormal_bone_strength0.63588396
152MP0005197_abnormal_uvea_morphology0.63371561
153MP0005165_increased_susceptibility_to0.62671145

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.30573643
2Hypoglycemic coma (HP:0001325)4.92328084
3Ketoacidosis (HP:0001993)3.89854218
4Hyperglycinuria (HP:0003108)3.79258503
5Xanthomatosis (HP:0000991)3.75822533
6Right ventricular cardiomyopathy (HP:0011663)3.67834797
7Hyperinsulinemic hypoglycemia (HP:0000825)3.65080750
8Vertebral compression fractures (HP:0002953)3.60380569
9Vacuolated lymphocytes (HP:0001922)3.55873607
10Hypoglycemic seizures (HP:0002173)3.40257665
11Dysostosis multiplex (HP:0000943)3.39501770
12Type 1 muscle fiber predominance (HP:0003803)3.39216743
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38929531
14Generalized aminoaciduria (HP:0002909)3.33021597
15Abnormality of glycine metabolism (HP:0010895)3.25149362
16Abnormality of serine family amino acid metabolism (HP:0010894)3.25149362
17Symptomatic seizures (HP:0011145)3.24598236
18Spinal rigidity (HP:0003306)3.23089246
19Ketosis (HP:0001946)3.21094432
20Abnormality of fatty-acid metabolism (HP:0004359)3.19278064
21Dicarboxylic aciduria (HP:0003215)3.15525146
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.15525146
23Shallow orbits (HP:0000586)3.11965054
24Intrahepatic cholestasis (HP:0001406)3.10395992
25Urinary glycosaminoglycan excretion (HP:0003541)3.09109365
26Mucopolysacchariduria (HP:0008155)3.09109365
27Mildly elevated creatine phosphokinase (HP:0008180)3.02510465
28Increased variability in muscle fiber diameter (HP:0003557)3.01997421
29Distal lower limb muscle weakness (HP:0009053)2.99999888
30Hyperglycemia (HP:0003074)2.98740986
31Myopathic facies (HP:0002058)2.87196630
32Abnormality of polysaccharide metabolism (HP:0011012)2.87121126
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87121126
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87121126
35Increased connective tissue (HP:0009025)2.83027683
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79980616
37Late onset (HP:0003584)2.79826172
38Abnormality of dentin (HP:0010299)2.79548127
39Ankle contracture (HP:0006466)2.76230656
40Distal upper limb amyotrophy (HP:0007149)2.74340593
41Upper limb amyotrophy (HP:0009129)2.74340593
42Abnormality of skeletal muscle fiber size (HP:0012084)2.72393353
43Thin bony cortex (HP:0002753)2.69073873
44Systemic lupus erythematosus (HP:0002725)2.68677690
45Hypobetalipoproteinemia (HP:0003563)2.67846048
46Protuberant abdomen (HP:0001538)2.65564625
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.64575573
48Cerebral aneurysm (HP:0004944)2.60101309
49Muscle fiber splitting (HP:0003555)2.59298171
50Gout (HP:0001997)2.59031498
51Back pain (HP:0003418)2.56532275
52Myoglobinuria (HP:0002913)2.55578816
53Fragile skin (HP:0001030)2.53532308
54Stridor (HP:0010307)2.53476359
55Ventricular tachycardia (HP:0004756)2.52663114
56Achilles tendon contracture (HP:0001771)2.52392769
57Bladder diverticulum (HP:0000015)2.51609453
58Broad metatarsal (HP:0001783)2.51578822
59Hypolipoproteinemia (HP:0010981)2.49202870
60Ileus (HP:0002595)2.49063334
61Increased cerebral lipofuscin (HP:0011813)2.48637617
62Insulin-resistant diabetes mellitus (HP:0000831)2.46911849
63Hyperammonemia (HP:0001987)2.46845379
64Biconcave vertebral bodies (HP:0004586)2.45941980
65Exercise-induced myalgia (HP:0003738)2.45788628
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.44575468
67Abdominal distention (HP:0003270)2.44495533
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43952421
69Abnormality of glycolipid metabolism (HP:0010969)2.38417158
70Abnormality of liposaccharide metabolism (HP:0010968)2.38417158
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.38417158
72Blue sclerae (HP:0000592)2.38148164
73Atrophic scars (HP:0001075)2.38132750
74Abnormality of purine metabolism (HP:0004352)2.36931312
75Fat malabsorption (HP:0002630)2.34418324
76Asymmetric septal hypertrophy (HP:0001670)2.34299058
77Hydroxyprolinuria (HP:0003080)2.33873189
78Abnormality of proline metabolism (HP:0010907)2.33873189
79Hypoalphalipoproteinemia (HP:0003233)2.33737230
80Ulnar bowing (HP:0003031)2.32340856
81Generalized amyotrophy (HP:0003700)2.31941207
82Wormian bones (HP:0002645)2.31725859
83Turricephaly (HP:0000262)2.31722810
84Abnormality of the Achilles tendon (HP:0005109)2.31570737
85Proximal tubulopathy (HP:0000114)2.31034342
86Complement deficiency (HP:0004431)2.30582723
87Axonal loss (HP:0003447)2.30572987
88Hyperglycinemia (HP:0002154)2.30204123
89Conjugated hyperbilirubinemia (HP:0002908)2.29308794
90Hyperlipoproteinemia (HP:0010980)2.28904621
91Distal lower limb amyotrophy (HP:0008944)2.27764494
92Neurofibrillary tangles (HP:0002185)2.26853262
93Breech presentation (HP:0001623)2.25889151
94Hyperactive renin-angiotensin system (HP:0000841)2.25866488
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25634121
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.24489177
97Premature rupture of membranes (HP:0001788)2.24258644
98Large for gestational age (HP:0001520)2.21060504
99Hyperacusis (HP:0010780)2.20916849
100Deep venous thrombosis (HP:0002625)2.14741213
101Skin nodule (HP:0200036)2.13754056
102Lymphangioma (HP:0100764)2.13434501
103Hand muscle atrophy (HP:0009130)2.12310554
104Cholecystitis (HP:0001082)2.12146843
105Abnormal gallbladder physiology (HP:0012438)2.12146843
106Malnutrition (HP:0004395)2.10207004
107Mitral regurgitation (HP:0001653)2.10076618
108Abnormality of urine glucose concentration (HP:0011016)2.07149013
109Glycosuria (HP:0003076)2.07149013
110J-shaped sella turcica (HP:0002680)2.06095715
111Abnormality of the intrinsic pathway (HP:0010989)2.05881654
112Abnormality of the acetabulum (HP:0003170)2.05672874
113Ragged-red muscle fibers (HP:0003200)2.05402689
114Premature skin wrinkling (HP:0100678)2.04864144
115Hypokalemia (HP:0002900)2.04762110
116Disproportionate tall stature (HP:0001519)2.03218482
117Vascular calcification (HP:0004934)2.02491566
118Palpitations (HP:0001962)2.01717747
119Elbow flexion contracture (HP:0002987)2.01231018
120Abnormality of chloride homeostasis (HP:0011422)2.00328624
121Bulbar palsy (HP:0001283)1.99944534
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99529030
123Aortic dissection (HP:0002647)1.99195326
124Soft skin (HP:0000977)1.95842490
125Neonatal short-limb short stature (HP:0008921)1.94770952
126Hyporeflexia of lower limbs (HP:0002600)1.94665639
127Difficulty climbing stairs (HP:0003551)1.94620913
128Prolonged partial thromboplastin time (HP:0003645)1.94567660
129Abnormality of complement system (HP:0005339)1.94337284
130Abnormal delivery (HP:0001787)1.93742535
131Glomerulonephritis (HP:0000099)1.93700155
132Long palpebral fissure (HP:0000637)1.93295354
133Cardiovascular calcification (HP:0011915)1.92337814
134Genu recurvatum (HP:0002816)1.92077914
135Cervical subluxation (HP:0003308)1.91619719
136Metabolic acidosis (HP:0001942)1.91466941
137Joint stiffness (HP:0001387)1.89827032
138Hypoventilation (HP:0002791)1.89812139
139Slender build (HP:0001533)1.88276882
140Rhabdomyolysis (HP:0003201)1.87105087
141Hypokalemic alkalosis (HP:0001949)1.86728273
142Syncope (HP:0001279)1.86427732
143Bundle branch block (HP:0011710)1.86305545
144Long toe (HP:0010511)1.86254294
145Irritability (HP:0000737)1.85577229
146Trismus (HP:0000211)1.85471468
147Hypercholesterolemia (HP:0003124)1.85439773
148Insulin resistance (HP:0000855)1.85204971
149Vascular tortuosity (HP:0004948)1.84713504
150Flat acetabular roof (HP:0003180)1.84447737
151Abnormality of the common coagulation pathway (HP:0010990)1.83798997
152Thin ribs (HP:0000883)1.82609653
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82308530
154Round ear (HP:0100830)1.82058591
155Nausea (HP:0002018)1.81898863
156Epidermoid cyst (HP:0200040)1.81100894
157Methylmalonic aciduria (HP:0012120)1.80425402
158Lethargy (HP:0001254)1.80013608
159Joint laxity (HP:0001388)1.79747407
160Myocardial infarction (HP:0001658)1.79561927
161Abnormal pancreas size (HP:0012094)1.79005180
162Hepatic necrosis (HP:0002605)1.77856331
163Decreased circulating renin level (HP:0003351)1.77287224
164Abnormal enzyme/coenzyme activity (HP:0012379)1.77244036
165Short nail (HP:0001799)1.76962252
166Aortic aneurysm (HP:0004942)1.76724067
167Nuclear cataract (HP:0100018)1.74855187
168Advanced eruption of teeth (HP:0006288)1.74318983
169Hypophosphatemia (HP:0002148)1.73690620
170Pterygium (HP:0001059)1.73236466
171Muscle stiffness (HP:0003552)1.72463097
172Abnormality of alkaline phosphatase activity (HP:0004379)1.72119659
173Platyspondyly (HP:0000926)1.72071476
174Coronal craniosynostosis (HP:0004440)1.69829429
175Ulnar deviation of the wrist (HP:0003049)1.68701628
176Cupped ribs (HP:0000887)1.67896080
177Aneurysm (HP:0002617)1.67593207
178Congenital glaucoma (HP:0001087)1.67502169
179Natal tooth (HP:0000695)1.67261607
180Atelectasis (HP:0100750)1.66759354
181Testicular atrophy (HP:0000029)1.66244318
182Hyperextensible skin (HP:0000974)1.65673590
183Bronchomalacia (HP:0002780)1.64767184
184Broad face (HP:0000283)1.63431414
185Neck muscle weakness (HP:0000467)1.63007199
186Bowel diverticulosis (HP:0005222)1.62470181
187Reticulocytosis (HP:0001923)1.62146698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.54705160
2INSRR3.47538616
3TRIB33.11455885
4BCKDK2.99721867
5SMG12.85679649
6MST1R2.68341140
7MET2.66462553
8EPHB12.45509196
9MAPK152.44348279
10LMTK22.25565544
11EPHA22.22879970
12MAP2K22.20465208
13IRAK32.12551093
14EEF2K2.11725583
15ICK2.10253764
16TTN2.03094989
17NME22.02031797
18WNK42.01094288
19SIK11.84336331
20PTK61.83571375
21RIPK11.70658701
22VRK21.68445240
23ARAF1.62803352
24FGFR41.62572582
25LIMK11.58787099
26MST41.49633646
27MAP3K31.48023264
28TESK21.44584604
29AKT31.41210161
30TAOK31.40028123
31PRPF4B1.34448362
32PRKD21.34239726
33PASK1.32579626
34TAOK21.28466306
35MAPKAPK31.23229072
36FRK1.22966735
37PRKD31.22440174
38FLT31.22197668
39EPHA31.21946925
40RPS6KA21.19541900
41DMPK1.14613102
42MYLK1.13699639
43PTK21.13240287
44STK38L1.13178274
45MAP3K21.12518822
46MUSK1.11351007
47BMX1.11326061
48OBSCN1.09838211
49PDGFRA1.09262139
50STK391.09079341
51TGFBR21.08621952
52PDK31.04932000
53PDK41.04932000
54MAP3K11.03543283
55PDK21.03500807
56PIK3CG1.00555380
57NLK0.99023900
58DDR20.97997899
59NEK90.96472489
60PAK30.92760477
61PKN20.90977992
62TRPM70.90685335
63RPS6KB20.87301611
64IRAK10.86184106
65DYRK1B0.85956318
66MAP3K100.85393857
67PRKG20.85206265
68PHKG20.83609809
69PHKG10.83609809
70PAK20.80753576
71FER0.79758324
72GSK3A0.77414310
73NUAK10.77162605
74TYK20.76874656
75LATS20.75661785
76LATS10.75465254
77CDK70.74925825
78NTRK10.74076292
79TBK10.73165613
80PIK3CA0.72527690
81RPS6KL10.72013316
82RPS6KC10.72013316
83WNK30.70969131
84EPHB20.70770118
85PRKD10.69970583
86PRKAA20.69072678
87CAMK2D0.68999936
88HIPK20.66822522
89KSR20.66573809
90ABL20.65811055
91MAP2K10.65014011
92CAMK1D0.64333929
93PIM20.63422059
94PINK10.62266970
95DAPK30.59932612
96MAP3K60.59027004
97NME10.56914053
98MAP3K70.52506314
99PRKCE0.51978422
100SCYL20.51474143
101PRKAA10.51411057
102CSK0.48319994
103MAPKAPK50.48286059
104CSNK1G30.47979512
105TIE10.47534845
106PDPK10.46828265
107RPS6KA60.46764825
108STK380.46760900
109MARK20.46560524
110AKT20.46435955
111TESK10.46001934
112PRKCI0.45826902
113PAK10.45683270
114CDC42BPA0.44714753
115ROCK20.44375512
116JAK20.43142601
117MAP3K80.42612646
118MAP2K30.42250282
119TYRO30.42060758
120JAK10.41577782
121CSNK1G10.41293575
122PRKACG0.41196006
123MAPK110.41194758
124RET0.41162275
125KDR0.39119844
126MOS0.38074937
127SGK4940.37593738
128SGK2230.37593738
129MAP3K110.37368532
130OXSR10.37303025
131LRRK20.37168760
132ERBB20.36918117
133CDK90.36570767
134ILK0.35468555
135BRAF0.35370371
136CDK11A0.35095879
137JAK30.34833391
138STK30.34810881
139CAMK2G0.34754917
140MTOR0.34493980
141PAK40.34268801
142CDK120.33728869
143ZAP700.33203064
144CSNK1A1L0.32185591
145ROCK10.31441761
146TAOK10.29681341

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.43575391
2Sulfur metabolism_Homo sapiens_hsa009203.02956889
3Fatty acid degradation_Homo sapiens_hsa000712.68408445
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60143989
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.53384227
6Fat digestion and absorption_Homo sapiens_hsa049752.21388470
7Folate biosynthesis_Homo sapiens_hsa007902.11941901
8Fatty acid metabolism_Homo sapiens_hsa012122.07062687
9Tryptophan metabolism_Homo sapiens_hsa003802.02573467
10Histidine metabolism_Homo sapiens_hsa003402.01788109
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96121816
12Butanoate metabolism_Homo sapiens_hsa006501.94444793
13Fatty acid elongation_Homo sapiens_hsa000621.92490664
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87760358
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86877636
16Propanoate metabolism_Homo sapiens_hsa006401.82023816
17Vitamin digestion and absorption_Homo sapiens_hsa049771.78483081
18PPAR signaling pathway_Homo sapiens_hsa033201.77167564
19Other glycan degradation_Homo sapiens_hsa005111.76837455
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72384824
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72027600
22Starch and sucrose metabolism_Homo sapiens_hsa005001.65763239
23Lysosome_Homo sapiens_hsa041421.65668719
24Protein export_Homo sapiens_hsa030601.65279568
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.64758279
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62771744
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62759849
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.59397596
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.52945724
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52934101
31Peroxisome_Homo sapiens_hsa041461.51844436
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46201002
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43494378
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40744388
35Mineral absorption_Homo sapiens_hsa049781.40256327
36Dilated cardiomyopathy_Homo sapiens_hsa054141.38493150
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37002689
38Notch signaling pathway_Homo sapiens_hsa043301.35020365
39beta-Alanine metabolism_Homo sapiens_hsa004101.34153039
40Steroid biosynthesis_Homo sapiens_hsa001001.33425501
41Staphylococcus aureus infection_Homo sapiens_hsa051501.33238823
42Nitrogen metabolism_Homo sapiens_hsa009101.33233703
43Complement and coagulation cascades_Homo sapiens_hsa046101.31114844
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30031236
45Caffeine metabolism_Homo sapiens_hsa002321.28507293
46Selenocompound metabolism_Homo sapiens_hsa004501.26451384
47Bladder cancer_Homo sapiens_hsa052191.23977273
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23649810
49Arginine and proline metabolism_Homo sapiens_hsa003301.20793386
50Focal adhesion_Homo sapiens_hsa045101.19804871
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19264633
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19194653
53Carbon metabolism_Homo sapiens_hsa012001.18510110
54Sphingolipid metabolism_Homo sapiens_hsa006001.17661145
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17364307
56Linoleic acid metabolism_Homo sapiens_hsa005911.17301245
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16588064
58Galactose metabolism_Homo sapiens_hsa000521.15576017
59Vitamin B6 metabolism_Homo sapiens_hsa007501.14750813
60ABC transporters_Homo sapiens_hsa020101.11580861
61Pyruvate metabolism_Homo sapiens_hsa006201.09832340
62Arginine biosynthesis_Homo sapiens_hsa002201.05182172
63Bile secretion_Homo sapiens_hsa049761.04629221
64Basal cell carcinoma_Homo sapiens_hsa052171.03034687
65Base excision repair_Homo sapiens_hsa034101.02442451
66Chemical carcinogenesis_Homo sapiens_hsa052041.02297374
67Fructose and mannose metabolism_Homo sapiens_hsa000511.02192895
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01615428
69Glutathione metabolism_Homo sapiens_hsa004800.99503769
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98817823
71Glycerolipid metabolism_Homo sapiens_hsa005610.96215153
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93964191
73Insulin signaling pathway_Homo sapiens_hsa049100.93415854
74Retinol metabolism_Homo sapiens_hsa008300.92316695
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91443290
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90645990
77Renin-angiotensin system_Homo sapiens_hsa046140.85552477
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85155993
79Tight junction_Homo sapiens_hsa045300.84058494
80Phenylalanine metabolism_Homo sapiens_hsa003600.83837913
81Arachidonic acid metabolism_Homo sapiens_hsa005900.81321699
82Sulfur relay system_Homo sapiens_hsa041220.80372663
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.80256887
84Glucagon signaling pathway_Homo sapiens_hsa049220.80217651
85Tyrosine metabolism_Homo sapiens_hsa003500.79767933
86Protein digestion and absorption_Homo sapiens_hsa049740.78306839
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.77931772
88Proteoglycans in cancer_Homo sapiens_hsa052050.74987245
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.72612676
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72191509
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71119189
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70204276
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68541280
94Thyroid cancer_Homo sapiens_hsa052160.68366942
95Insulin resistance_Homo sapiens_hsa049310.67135427
96Pentose phosphate pathway_Homo sapiens_hsa000300.64269088
97Lysine degradation_Homo sapiens_hsa003100.63245036
98Endometrial cancer_Homo sapiens_hsa052130.61457326
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59254744
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58887129
101Melanogenesis_Homo sapiens_hsa049160.58830115
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57998213
103Hedgehog signaling pathway_Homo sapiens_hsa043400.57881492
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56850685
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.56473879
106Hippo signaling pathway_Homo sapiens_hsa043900.55967011
107Metabolic pathways_Homo sapiens_hsa011000.55951555
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55318669
109Biosynthesis of amino acids_Homo sapiens_hsa012300.54227059
110Regulation of autophagy_Homo sapiens_hsa041400.53796788
111Axon guidance_Homo sapiens_hsa043600.53176695
112Chronic myeloid leukemia_Homo sapiens_hsa052200.52101354
113Ether lipid metabolism_Homo sapiens_hsa005650.51597966
114Small cell lung cancer_Homo sapiens_hsa052220.51281796
115Acute myeloid leukemia_Homo sapiens_hsa052210.48708478
116VEGF signaling pathway_Homo sapiens_hsa043700.47767309
117Prion diseases_Homo sapiens_hsa050200.47765770
118Adherens junction_Homo sapiens_hsa045200.47624330
119Fatty acid biosynthesis_Homo sapiens_hsa000610.47222982
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47069400
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42157478
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41277567
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41169844
124Cardiac muscle contraction_Homo sapiens_hsa042600.39156779
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36024515
126Vibrio cholerae infection_Homo sapiens_hsa051100.35706348
127ECM-receptor interaction_Homo sapiens_hsa045120.34851568
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34504956
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34253904
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.33006492
131N-Glycan biosynthesis_Homo sapiens_hsa005100.32302764
132mTOR signaling pathway_Homo sapiens_hsa041500.31584121
133Oxidative phosphorylation_Homo sapiens_hsa001900.31228467
134Amoebiasis_Homo sapiens_hsa051460.30761156
135Legionellosis_Homo sapiens_hsa051340.30337490
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28073280
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.24407069
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23665329
139Thyroid hormone synthesis_Homo sapiens_hsa049180.22573942
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21745721
141Pancreatic secretion_Homo sapiens_hsa049720.21083745
142AMPK signaling pathway_Homo sapiens_hsa041520.20380740

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