ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.54423754
2	spermatid development (GO:0007286)	9.54336362
3	motile cilium assembly (GO:0044458)	9.44338800
4	cilium movement (GO:0003341)	8.37291807
5	cilium or flagellum-dependent cell motility (GO:0001539)	8.29116966
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.69976623
7	single fertilization (GO:0007338)	7.38375124
8	spermatid nucleus differentiation (GO:0007289)	7.26661714
9	sperm capacitation (GO:0048240)	7.26039253
10	regulation of cilium movement (GO:0003352)	7.00607194
11	synaptonemal complex assembly (GO:0007130)	7.00233169
12	male meiosis (GO:0007140)	6.94787133
13	synaptonemal complex organization (GO:0070193)	6.92525094
14	negative regulation of inclusion body assembly (GO:0090084)	6.38985393
15	piRNA metabolic process (GO:0034587)	6.38895925
16	spermatogenesis (GO:0007283)	6.26290916
17	male gamete generation (GO:0048232)	6.23983877
18	fertilization (GO:0009566)	6.23685494
19	sexual reproduction (GO:0019953)	6.15602387
20	microtubule depolymerization (GO:0007019)	6.01619549
21	single strand break repair (GO:0000012)	5.99472466
22	calcium ion-dependent exocytosis (GO:0017156)	5.73809296
23	gamete generation (GO:0007276)	5.73515582
24	organic cation transport (GO:0015695)	5.73355314
25	regulation of inclusion body assembly (GO:0090083)	5.37238424
26	germ cell development (GO:0007281)	5.35820426
27	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.26320413
28	cell recognition (GO:0008037)	5.13536130
29	glycerol ether metabolic process (GO:0006662)	4.96120655
30	protein K11-linked deubiquitination (GO:0035871)	4.92844292
31	ventricular system development (GO:0021591)	4.82824458
32	chromosome organization involved in meiosis (GO:0070192)	4.65365237
33	ether metabolic process (GO:0018904)	4.57930768
34	microtubule severing (GO:0051013)	4.57808998
35	multicellular organismal reproductive process (GO:0048609)	4.49184789
36	seminiferous tubule development (GO:0072520)	4.40828335
37	monoubiquitinated protein deubiquitination (GO:0035520)	4.35010269
38	DNA methylation involved in gamete generation (GO:0043046)	4.24199714
39	chromosome condensation (GO:0030261)	4.22736321
40	regulation of microtubule-based movement (GO:0060632)	4.18116168
41	sequestering of actin monomers (GO:0042989)	4.11135077
42	DNA packaging (GO:0006323)	3.95540309
43	meiotic nuclear division (GO:0007126)	3.90747318
44	chaperone-mediated protein complex assembly (GO:0051131)	3.81439168
45	male meiosis I (GO:0007141)	3.80835057
46	genitalia morphogenesis (GO:0035112)	3.77681446
47	left/right pattern formation (GO:0060972)	3.74281220
48	multicellular organismal development (GO:0007275)	3.62260239
49	GTP biosynthetic process (GO:0006183)	3.27093816
50	polyol catabolic process (GO:0046174)	3.24999893
51	microtubule polymerization or depolymerization (GO:0031109)	3.20486873
52	glycolytic process (GO:0006096)	3.15223877
53	chromatin silencing (GO:0006342)	3.11875114
54	nucleoside diphosphate phosphorylation (GO:0006165)	3.06379272
55	alditol metabolic process (GO:0019400)	2.99407239
56	meiosis I (GO:0007127)	2.96926174
57	nucleus organization (GO:0006997)	2.93437665
58	positive regulation of macrophage activation (GO:0043032)	2.89606091
59	UTP biosynthetic process (GO:0006228)	2.88046664
60	cilium organization (GO:0044782)	2.86786233
61	centriole assembly (GO:0098534)	2.86379317
62	macroautophagy (GO:0016236)	2.84421869
63	lactate metabolic process (GO:0006089)	2.83745594
64	meiotic cell cycle (GO:0051321)	2.79152664
65	protein refolding (GO:0042026)	2.78614355
66	protein polyglutamylation (GO:0018095)	2.78394313
67	amino-acid betaine transport (GO:0015838)	2.77769843
68	carnitine transport (GO:0015879)	2.77769843
69	cilium assembly (GO:0042384)	2.77602109
70	cellular component assembly involved in morphogenesis (GO:0010927)	2.76397546
71	glycerol metabolic process (GO:0006071)	2.68891875
72	microtubule-based movement (GO:0007018)	2.67926596
73	interferon-gamma secretion (GO:0072643)	2.67432792
74	carnitine transmembrane transport (GO:1902603)	2.65829112
75	protein localization to cilium (GO:0061512)	2.64952364
76	UTP metabolic process (GO:0046051)	2.58981844
77	cellular response to arsenic-containing substance (GO:0071243)	2.57597419
78	gene silencing by RNA (GO:0031047)	2.56077789
79	cell redox homeostasis (GO:0045454)	2.55651412
80	protein-DNA complex disassembly (GO:0032986)	2.53481306
81	nucleosome disassembly (GO:0006337)	2.53481306
82	gene silencing (GO:0016458)	2.52689708
83	mitotic sister chromatid cohesion (GO:0007064)	2.51911267
84	intraciliary transport (GO:0042073)	2.47529164
85	regulation of spindle checkpoint (GO:0090231)	2.47120117
86	cilium morphogenesis (GO:0060271)	2.42002045
87	synapsis (GO:0007129)	2.40562126
88	cell wall macromolecule catabolic process (GO:0016998)	15.8299640
89	cell wall macromolecule metabolic process (GO:0044036)	15.8299640
90	fusion of sperm to egg plasma membrane (GO:0007342)	13.9413845
91	sperm motility (GO:0030317)	13.6748228
92	acrosome assembly (GO:0001675)	12.4092856
93	sperm-egg recognition (GO:0035036)	11.5021583
94	acrosome reaction (GO:0007340)	11.2783452
95	multicellular organism reproduction (GO:0032504)	11.2183035
96	epithelial cilium movement (GO:0003351)	10.6947443
97	plasma membrane fusion (GO:0045026)	10.6883021
98	binding of sperm to zona pellucida (GO:0007339)	10.6651195
99	cell-cell recognition (GO:0009988)	10.3467419
100	reproduction (GO:0000003)	10.0933525

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.29080392
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.98507500
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.82095869
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.57217506
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.00757584
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.86881291
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.63823516
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.34421691
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.32858159
10	VDR_22108803_ChIP-Seq_LS180_Human	2.25180552
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.13700587
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.07142431
13	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.04833934
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04421658
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.04249281
16	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.01576303
17	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.96237896
18	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.84049153
19	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.82427860
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.78427006
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.77766859
22	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.75997272
23	KDM2B_26808549_Chip-Seq_REH_Human	1.75422442
24	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.64650724
25	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.63203740
26	STAT1_17558387_ChIP-Seq_HELA_Human	1.63177423
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62722582
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.62433448
29	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.61959498
30	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.60780005
31	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.57817757
32	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.56844597
33	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.51547210
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.51342102
35	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.49498938
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48925664
37	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.47587426
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47054817
39	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.43213239
40	P53_22387025_ChIP-Seq_ESCs_Mouse	1.42261553
41	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.41705549
42	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.40272833
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38680547
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.38680547
45	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.38521220
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37488570
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.36032595
48	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34084027
49	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33538869
50	P300_18555785_Chip-Seq_ESCs_Mouse	1.33288826
51	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.33250819
52	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.33020939
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30255487
54	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28740077
55	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.24637203
56	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.22849160
57	SOX9_26525672_Chip-Seq_HEART_Mouse	1.19661334
58	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.19245128
59	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.19013914
60	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.18393432
61	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.18159077
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17316656
63	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.16635596
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15749184
65	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.14512950
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13849697
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13849697
68	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.12281380
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11962092
70	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10962510
71	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.09979676
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09735294
73	PU1_27457419_Chip-Seq_LIVER_Mouse	1.07811031
74	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.07576975
75	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06754591
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06262018
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05975150
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05040592
79	GF1_26923725_Chip-Seq_HPCs_Mouse	1.04371842
80	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.03850219
81	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.03331524
82	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.02976149
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.02322642
84	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.01958589
85	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.00078773
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99797117
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98911843
88	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.98010850
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96270211
90	NFYB_21822215_ChIP-Seq_K562_Human	0.95848064
91	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93988784
92	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.93503230
93	TBL1_22424771_ChIP-Seq_293T_Human	0.92375932
94	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.91668097
95	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.91402861
96	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.90541994
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89187525
98	FUS_26573619_Chip-Seq_HEK293_Human	0.88195537
99	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.88180814
100	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.87435709

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.12424081
2	MP0001929_abnormal_gametogenesis	5.58244163
3	MP0008877_abnormal_DNA_methylation	4.36565434
4	MP0002161_abnormal_fertility/fecundity	3.31226037
5	MP0002210_abnormal_sex_determination	3.26838618
6	MP0001145_abnormal_male_reproductive	2.82652947
7	MP0000653_abnormal_sex_gland	2.43849082
8	MP0005670_abnormal_white_adipose	2.26486481
9	MP0005410_abnormal_fertilization	16.1823626
10	MP0002160_abnormal_reproductive_system	1.60027638
11	MP0004233_abnormal_muscle_weight	1.56047703
12	MP0002653_abnormal_ependyma_morphology	1.41766686
13	MP0001765_abnormal_ion_homeostasis	1.27516864
14	MP0002282_abnormal_trachea_morphology	1.24517245
15	MP0005623_abnormal_meninges_morphology	1.22565068
16	MP0009046_muscle_twitch	1.17224057
17	MP0005647_abnormal_sex_gland	1.12856440
18	MP0008058_abnormal_DNA_repair	1.03812002
19	MP0003646_muscle_fatigue	1.01177637
20	MP0002736_abnormal_nociception_after	0.91056367
21	MP0004270_analgesia	0.90425098
22	MP0003329_amyloid_beta_deposits	0.89485789
23	MP0005389_reproductive_system_phenotype	0.85179347
24	MP0003787_abnormal_imprinting	0.83464265
25	MP0002132_abnormal_respiratory_system	0.82367560
26	MP0006035_abnormal_mitochondrial_morpho	0.80187451
27	MP0008995_early_reproductive_senescence	0.78706660
28	MP0006036_abnormal_mitochondrial_physio	0.78604518
29	MP0002234_abnormal_pharynx_morphology	0.75335681
30	MP0004036_abnormal_muscle_relaxation	0.74107541
31	MP0005551_abnormal_eye_electrophysiolog	0.72227812
32	MP0005636_abnormal_mineral_homeostasis	0.68061923
33	MP0003011_delayed_dark_adaptation	0.67970024
34	MP0001968_abnormal_touch/_nociception	0.67012412
35	MP0002971_abnormal_brown_adipose	0.66371494
36	MP0001984_abnormal_olfaction	0.65924926
37	MP0003631_nervous_system_phenotype	0.63194774
38	MP0004019_abnormal_vitamin_homeostasis	0.62531561
39	MP0003633_abnormal_nervous_system	0.60983298
40	MP0001324_abnormal_eye_pigmentation	0.60251877
41	MP0003632_abnormal_nervous_system	0.57925594
42	MP0004859_abnormal_synaptic_plasticity	0.53399474
43	MP0005253_abnormal_eye_physiology	0.51735571
44	MP0003635_abnormal_synaptic_transmissio	0.49230867
45	MP0005248_abnormal_Harderian_gland	0.48269509
46	MP0000604_amyloidosis	0.46493069
47	MP0003699_abnormal_female_reproductive	0.43251699
48	MP0000534_abnormal_ureter_morphology	0.42293544
49	MP0004043_abnormal_pH_regulation	0.42244039
50	MP0002064_seizures	0.41667844
51	MP0004811_abnormal_neuron_physiology	0.40655334
52	MP0003115_abnormal_respiratory_system	0.39467503
53	MP0005646_abnormal_pituitary_gland	0.39152959
54	MP0009745_abnormal_behavioral_response	0.38977165
55	MP0002139_abnormal_hepatobiliary_system	0.38575923
56	MP0004130_abnormal_muscle_cell	0.38211118
57	MP0004133_heterotaxia	0.37900378
58	MP0004084_abnormal_cardiac_muscle	0.37728688
59	MP0008569_lethality_at_weaning	0.37545197
60	MP0000955_abnormal_spinal_cord	0.37528322
61	MP0004145_abnormal_muscle_electrophysio	0.37221791
62	MP0005535_abnormal_body_temperature	0.37140755
63	MP0002063_abnormal_learning/memory/cond	0.36946239
64	MP0000920_abnormal_myelination	0.35161657
65	MP0002102_abnormal_ear_morphology	0.34955388
66	MP0002272_abnormal_nervous_system	0.34885798
67	MP0001764_abnormal_homeostasis	0.34773724
68	MP0002269_muscular_atrophy	0.34771681
69	MP0006072_abnormal_retinal_apoptosis	0.33798583
70	MP0001440_abnormal_grooming_behavior	0.33393446
71	MP0010094_abnormal_chromosome_stability	0.32970625
72	MP0002572_abnormal_emotion/affect_behav	0.32566672
73	MP0006082_CNS_inflammation	0.32262830
74	MP0002152_abnormal_brain_morphology	0.31599463
75	MP0002693_abnormal_pancreas_physiology	0.30237970
76	MP0000358_abnormal_cell_content/	0.29586924
77	MP0003879_abnormal_hair_cell	0.29563124
78	MP0002909_abnormal_adrenal_gland	0.28362201
79	MP0005391_vision/eye_phenotype	0.27241013
80	MP0005666_abnormal_adipose_tissue	0.26900613
81	MP0002928_abnormal_bile_duct	0.26887103
82	MP0002229_neurodegeneration	0.26653902
83	MP0005195_abnormal_posterior_eye	0.26608678
84	MP0001502_abnormal_circadian_rhythm	0.26388366
85	MP0000751_myopathy	0.25941786
86	MP0005423_abnormal_somatic_nervous	0.24262125
87	MP0009115_abnormal_fat_cell	0.24220607
88	MP0002734_abnormal_mechanical_nocicepti	0.23921970
89	MP0003950_abnormal_plasma_membrane	0.23659670
90	MP0000569_abnormal_digit_pigmentation	0.23582809
91	MP0002067_abnormal_sensory_capabilities	0.23525926
92	MP0008057_abnormal_DNA_replication	0.23410943
93	MP0002169_no_abnormal_phenotype	0.23254171
94	MP0002873_normal_phenotype	0.23229930
95	MP0001486_abnormal_startle_reflex	0.22029920
96	MP0001293_anophthalmia	0.21314070
97	MP0002277_abnormal_respiratory_mucosa	0.21284174
98	MP0003634_abnormal_glial_cell	0.20706841
99	MP0010030_abnormal_orbit_morphology	0.20430673
100	MP0003045_fibrosis	0.20269103

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.44882953
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.44882953
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.38359226
4	Abnormal ciliary motility (HP:0012262)	7.76078954
5	Chronic bronchitis (HP:0004469)	7.63043092
6	Rhinitis (HP:0012384)	7.29739362
7	Infertility (HP:0000789)	6.27680370
8	Nasal polyposis (HP:0100582)	6.06340855
9	Abnormality of the nasal mucosa (HP:0000433)	4.96501167
10	Bronchitis (HP:0012387)	4.26417432
11	Bronchiectasis (HP:0002110)	4.15992497
12	Male infertility (HP:0003251)	3.86410059
13	Recurrent sinusitis (HP:0011108)	3.74795996
14	Nephronophthisis (HP:0000090)	3.67176259
15	Recurrent otitis media (HP:0000403)	3.12993701
16	Tubulointerstitial nephritis (HP:0001970)	2.95846485
17	Progressive inability to walk (HP:0002505)	2.93409399
18	Abnormal spermatogenesis (HP:0008669)	2.88056515
19	Abnormality of the renal medulla (HP:0100957)	2.80106261
20	Facial diplegia (HP:0001349)	2.77263700
21	Medial flaring of the eyebrow (HP:0010747)	2.67680398
22	Molar tooth sign on MRI (HP:0002419)	2.51070315
23	Abnormality of midbrain morphology (HP:0002418)	2.51070315
24	Tubulointerstitial abnormality (HP:0001969)	2.17064589
25	Tubular atrophy (HP:0000092)	2.12206410
26	Abnormality of permanent molar morphology (HP:0011071)	2.05293746
27	Abnormality of the dental root (HP:0006486)	2.05293746
28	Taurodontia (HP:0000679)	2.05293746
29	Recurrent bronchitis (HP:0002837)	2.02000326
30	Gonadotropin excess (HP:0000837)	2.00044558
31	Absent/shortened dynein arms (HP:0200106)	13.9459621
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.9459621
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.9987411
34	Azoospermia (HP:0000027)	1.90781946
35	Abnormality of molar morphology (HP:0011070)	1.90424683
36	Abnormality of molar (HP:0011077)	1.90424683
37	Abnormality of the dental pulp (HP:0006479)	1.88987976
38	Cholecystitis (HP:0001082)	1.87357350
39	Abnormal gallbladder physiology (HP:0012438)	1.87357350
40	Asymmetric septal hypertrophy (HP:0001670)	1.85727267
41	Dyschromatopsia (HP:0007641)	1.83380597
42	Delayed gross motor development (HP:0002194)	1.82601593
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.82490057
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.82490057
45	Stage 5 chronic kidney disease (HP:0003774)	1.74874746
46	Absent frontal sinuses (HP:0002688)	1.74772962
47	Inability to walk (HP:0002540)	1.73856975
48	Weak cry (HP:0001612)	1.67765995
49	Gait imbalance (HP:0002141)	1.61311023
50	Oculomotor apraxia (HP:0000657)	1.59070042
51	Bundle branch block (HP:0011710)	1.58753220
52	Decreased central vision (HP:0007663)	1.58487845
53	Congenital primary aphakia (HP:0007707)	1.57767152
54	Postaxial foot polydactyly (HP:0001830)	1.57162913
55	Abnormality of dentin (HP:0010299)	1.56481761
56	Aplasia/Hypoplasia of the lens (HP:0008063)	1.54002934
57	Abnormality of the renal cortex (HP:0011035)	1.53733577
58	Abnormality of renal excretion (HP:0011036)	1.50727027
59	Double outlet right ventricle (HP:0001719)	1.48960861
60	Congenital malformation of the right heart (HP:0011723)	1.48960861
61	Tubulointerstitial fibrosis (HP:0005576)	1.48901977
62	Congenital hepatic fibrosis (HP:0002612)	1.47653463
63	Vascular calcification (HP:0004934)	1.47415480
64	Constricted visual fields (HP:0001133)	1.45058827
65	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.43157737
66	Abnormality of renal resorption (HP:0011038)	1.42597616
67	Nephrogenic diabetes insipidus (HP:0009806)	1.41927552
68	Optic nerve hypoplasia (HP:0000609)	1.40934208
69	Choroideremia (HP:0001139)	1.40894606
70	Chronic sinusitis (HP:0011109)	1.40569439
71	Impulsivity (HP:0100710)	1.38856780
72	Abnormality of saccadic eye movements (HP:0000570)	1.37376862
73	Retrobulbar optic neuritis (HP:0100654)	1.35815204
74	Optic neuritis (HP:0100653)	1.35815204
75	Abnormality of ocular smooth pursuit (HP:0000617)	1.35594618
76	Postaxial hand polydactyly (HP:0001162)	1.34427294
77	J-shaped sella turcica (HP:0002680)	1.33552661
78	Impaired smooth pursuit (HP:0007772)	1.32802281
79	Sensory axonal neuropathy (HP:0003390)	1.32273665
80	Cardiovascular calcification (HP:0011915)	1.31856079
81	Heterotopia (HP:0002282)	1.31258205
82	Ragged-red muscle fibers (HP:0003200)	1.30956073
83	Fibular hypoplasia (HP:0003038)	1.29319187
84	Spastic tetraparesis (HP:0001285)	1.28965286
85	Polydipsia (HP:0001959)	1.27846166
86	Abnormal drinking behavior (HP:0030082)	1.27846166
87	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.26114168
88	Hemorrhage of the eye (HP:0011885)	1.22980794
89	Gowers sign (HP:0003391)	1.22711020
90	Neurofibrillary tangles (HP:0002185)	1.22436775
91	Short ribs (HP:0000773)	1.20868164
92	Abnormal biliary tract physiology (HP:0012439)	1.20363151
93	Bile duct proliferation (HP:0001408)	1.20363151
94	Truncal obesity (HP:0001956)	1.19988118
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.19420172
96	Vaginal atresia (HP:0000148)	1.18959049
97	Cystic liver disease (HP:0006706)	1.17946717
98	Pancreatic fibrosis (HP:0100732)	1.17118568
99	Chronic hepatic failure (HP:0100626)	1.16235222
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.16170420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	9.99715809
2	PDK4	9.99715809
3	PDK2	6.50246326
4	TESK1	3.70499732
5	ICK	2.83054316
6	PRKD3	2.71044105
7	PTK2B	1.74485014
8	STK39	1.56526941
9	WNK4	1.51310211
10	PDK1	1.28548712
11	PNCK	1.23411147
12	DYRK1B	1.17819693
13	STK38	1.17348262
14	RIPK4	0.99850807
15	NEK2	0.99194267
16	IRAK1	0.88828238
17	LMTK2	0.72608301
18	WNK1	0.70651816
19	PDPK1	0.64611822
20	CCNB1	0.53475820
21	MAP2K6	0.50212385
22	DYRK3	0.49177790
23	TYRO3	0.44520163
24	STK3	0.42719658
25	PINK1	0.42196298
26	PASK	0.40766095
27	IRAK2	0.40695498
28	CAMKK1	0.39880198
29	BRSK2	0.39144305
30	TTK	0.32129015
31	CHEK2	0.31664270
32	MUSK	0.30517267
33	PRKCG	0.28950568
34	MAPK15	0.28774718
35	NTRK2	0.26794636
36	MAP3K4	0.24548011
37	CHEK1	0.24004427
38	PKN1	0.23243137
39	CDK6	0.21166548
40	PRKCQ	0.20013566
41	MAP2K7	0.19326054
42	EEF2K	0.18423275
43	MARK3	0.18309340
44	PAK1	0.17877953
45	PLK4	0.16508636
46	TESK2	0.16440133
47	RPS6KB1	0.16183890
48	CAMK1G	0.16101912
49	CDK19	0.15848809
50	OXSR1	0.15091341
51	ATM	0.14545277
52	CAMKK2	0.14347707
53	STK38L	0.14318814
54	PRKG1	0.13637341
55	CAMK2A	0.13621595
56	MARK2	0.12024467
57	NEK6	0.11902932
58	PRKG2	0.10925892
59	NTRK3	0.10813780
60	PAK2	0.10199465
61	MAPKAPK5	0.10179160
62	BRSK1	0.09974138
63	CDK15	0.09757192
64	DYRK1A	0.09207220
65	BRAF	0.08621046
66	PRKACG	0.08564551
67	CDK18	0.08105169
68	PRKAA1	0.08017231
69	CDK5	0.07822682
70	EPHA4	0.07793342
71	UHMK1	0.07022911
72	ATR	0.06081851
73	PRKCZ	0.05833342
74	CDK11A	0.05691231
75	CDK14	0.05595553
76	MAPK8	0.05377507
77	MINK1	0.05322083
78	YES1	0.04694419
79	PLK2	0.04568934
80	RPS6KA3	0.04131596
81	BMPR1B	0.04112154
82	MAP3K10	0.04098579
83	FGFR3	0.03978942
84	MAPK10	0.03760998
85	GSK3B	0.03715020
86	MTOR	0.03133388
87	STK11	0.02699399
88	EGFR	0.02139226
89	CAMK2B	0.02061474
90	GSK3A	0.01885454
91	PRKACA	0.01654195
92	PRKCB	0.01561060
93	CSNK1E	0.01496214
94	PRKCA	0.01468004
95	CDC7	0.01403516
96	MAP3K5	0.01342264
97	NTRK1	0.01290479
98	CSNK1D	0.01079656
99	PRKACB	0.00980942
100	CSNK2A2	0.00975260

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.28233402
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.21913232
3	Pyruvate metabolism_Homo sapiens_hsa00620	3.82221182
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.30767655
5	Propanoate metabolism_Homo sapiens_hsa00640	2.90748868
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.88163403
7	Glucagon signaling pathway_Homo sapiens_hsa04922	2.79868612
8	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.65490281
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.56532316
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.54781214
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.53076786
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52112246
13	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.16391960
14	Basal transcription factors_Homo sapiens_hsa03022	1.90106607
15	Oocyte meiosis_Homo sapiens_hsa04114	1.86555076
16	Amphetamine addiction_Homo sapiens_hsa05031	1.82521904
17	Glycerolipid metabolism_Homo sapiens_hsa00561	1.63815580
18	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.61532998
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.61053272
20	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.57250463
21	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.53698021
22	Pentose phosphate pathway_Homo sapiens_hsa00030	1.47915868
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46930583
24	Renin secretion_Homo sapiens_hsa04924	1.45788667
25	Mineral absorption_Homo sapiens_hsa04978	1.42996366
26	PPAR signaling pathway_Homo sapiens_hsa03320	1.42870217
27	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.37948437
28	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.30459785
29	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.29849232
30	Carbon metabolism_Homo sapiens_hsa01200	1.28117638
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.27238791
32	Long-term potentiation_Homo sapiens_hsa04720	1.22455315
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.21688637
34	Insulin secretion_Homo sapiens_hsa04911	1.10449512
35	Taste transduction_Homo sapiens_hsa04742	1.07403546
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02426113
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98989943
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.97832836
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.97554778
40	Purine metabolism_Homo sapiens_hsa00230	0.97177636
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.93747482
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93034604
43	Salivary secretion_Homo sapiens_hsa04970	0.92298782
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.92092317
45	Circadian entrainment_Homo sapiens_hsa04713	0.89610918
46	Huntingtons disease_Homo sapiens_hsa05016	0.89537231
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89049691
48	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.88743565
49	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.88685931
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85670169
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.84224443
52	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.77083431
53	Bile secretion_Homo sapiens_hsa04976	0.76518162
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.75724509
55	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.74405558
56	Gastric acid secretion_Homo sapiens_hsa04971	0.74223217
57	Fatty acid degradation_Homo sapiens_hsa00071	0.74015322
58	Pancreatic secretion_Homo sapiens_hsa04972	0.71323448
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71082117
60	Glutathione metabolism_Homo sapiens_hsa00480	0.70615609
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.62397387
62	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62274747
63	Sulfur metabolism_Homo sapiens_hsa00920	0.61285267
64	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61277459
65	Estrogen signaling pathway_Homo sapiens_hsa04915	0.60275397
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.60123071
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.59266748
68	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.59020602
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58547277
70	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57988869
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.57861163
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55341755
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54534608
74	VEGF signaling pathway_Homo sapiens_hsa04370	0.50913866
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49900038
76	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49121041
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47169956
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46355256
79	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.45134503
80	ABC transporters_Homo sapiens_hsa02010	0.44976087
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42715765
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42567845
83	Metabolic pathways_Homo sapiens_hsa01100	0.37496949
84	RNA transport_Homo sapiens_hsa03013	0.36567168
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.34560517
86	Endocytosis_Homo sapiens_hsa04144	0.32608114
87	Nicotine addiction_Homo sapiens_hsa05033	0.32156906
88	AMPK signaling pathway_Homo sapiens_hsa04152	0.31804016
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31040410
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.29846362
91	Alcoholism_Homo sapiens_hsa05034	0.29505669
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28840877
93	Olfactory transduction_Homo sapiens_hsa04740	0.28095559
94	Legionellosis_Homo sapiens_hsa05134	0.27506384
95	Morphine addiction_Homo sapiens_hsa05032	0.25953358
96	Cocaine addiction_Homo sapiens_hsa05030	0.25693441
97	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.23920340
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.21092896
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.19782863
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.18898910

FAM24A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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