ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	9.95616547
2	multicellular organismal water homeostasis (GO:0050891)	8.94709631
3	epidermis development (GO:0008544)	7.87788771
4	hair cycle (GO:0042633)	7.54267789
5	molting cycle (GO:0042303)	7.54267789
6	keratinocyte proliferation (GO:0043616)	7.49208849
7	water homeostasis (GO:0030104)	7.47192520
8	long-chain fatty acid biosynthetic process (GO:0042759)	6.48448298
9	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.10823071
10	lipoxygenase pathway (GO:0019372)	6.10615946
11	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	5.49820950
12	detection of bacterium (GO:0016045)	5.18300240
13	intermediate filament cytoskeleton organization (GO:0045104)	5.01007634
14	regulation of T cell chemotaxis (GO:0010819)	4.88857032
15	positive regulation of T cell chemotaxis (GO:0010820)	4.88857032
16	gap junction assembly (GO:0016264)	4.85707139
17	intermediate filament-based process (GO:0045103)	4.85053372
18	negative regulation of cell fate specification (GO:0009996)	4.80619200
19	negative regulation of interferon-gamma production (GO:0032689)	4.73237468
20	linoleic acid metabolic process (GO:0043651)	4.66867881
21	detection of other organism (GO:0098543)	4.65871872
22	keratinocyte development (GO:0003334)	4.65308156
23	positive regulation of monocyte chemotaxis (GO:0090026)	4.57866129
24	intermediate filament organization (GO:0045109)	4.51350029
25	skin morphogenesis (GO:0043589)	4.41625910
26	regulation of natural killer cell differentiation (GO:0032823)	4.34891587
27	hair cell differentiation (GO:0035315)	4.25575505
28	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.19920648
29	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.02042604
30	negative regulation of cell fate commitment (GO:0010454)	3.95220186
31	negative regulation of interleukin-17 production (GO:0032700)	3.94497538
32	ectoderm development (GO:0007398)	3.92593341
33	sequestering of metal ion (GO:0051238)	3.88825167
34	surfactant homeostasis (GO:0043129)	3.88077524
35	epithelium development (GO:0060429)	3.85520919
36	hemidesmosome assembly (GO:0031581)	3.83687732
37	hair follicle morphogenesis (GO:0031069)	3.82758960
38	positive regulation of epidermis development (GO:0045684)	3.75984618
39	positive regulation of epidermal cell differentiation (GO:0045606)	3.73447292
40	ribosomal small subunit biogenesis (GO:0042274)	3.71693010
41	4-hydroxyproline metabolic process (GO:0019471)	3.58887464
42	positive regulation of keratinocyte differentiation (GO:0045618)	3.56669829
43	intestinal epithelial cell development (GO:0060576)	3.42499848
44	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.35875671
45	epithelial cell differentiation (GO:0030855)	3.34363666
46	chemical homeostasis within a tissue (GO:0048875)	3.34268852
47	regulation of keratinocyte differentiation (GO:0045616)	3.31765527
48	negative regulation of keratinocyte proliferation (GO:0010839)	3.27045440
49	antimicrobial humoral response (GO:0019730)	3.25507628
50	positive regulation of granulocyte chemotaxis (GO:0071624)	3.23436467
51	regulation of monocyte chemotaxis (GO:0090025)	3.14662956
52	embryonic heart tube development (GO:0035050)	3.08666917
53	regulation of transforming growth factor beta1 production (GO:0032908)	3.08537356
54	regulation of mesoderm development (GO:2000380)	3.05536487
55	regulation of T cell migration (GO:2000404)	3.03903840
56	establishment of planar polarity (GO:0001736)	3.03661152
57	establishment of tissue polarity (GO:0007164)	3.03661152
58	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.03439048
59	keratinization (GO:0031424)	25.5347771
60	defense response to fungus (GO:0050832)	2.98453200
61	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.98092543
62	mRNA transcription (GO:0009299)	2.92183267
63	mature B cell differentiation involved in immune response (GO:0002313)	2.87377198
64	ceramide biosynthetic process (GO:0046513)	2.84635890
65	defense response to Gram-negative bacterium (GO:0050829)	2.84603061
66	regulation of epidermis development (GO:0045682)	2.83110982
67	phosphatidylserine metabolic process (GO:0006658)	2.82797965
68	regulation of lymphocyte chemotaxis (GO:1901623)	2.79620907
69	regulation of epidermal cell differentiation (GO:0045604)	2.74690458
70	regulation of neuron projection regeneration (GO:0070570)	2.73687384
71	regulation of axon regeneration (GO:0048679)	2.73687384
72	positive regulation of skeletal muscle tissue development (GO:0048643)	2.73640368
73	positive regulation of T cell migration (GO:2000406)	2.72138871
74	one-carbon compound transport (GO:0019755)	2.70214119
75	detection of external biotic stimulus (GO:0098581)	2.65445883
76	embryonic foregut morphogenesis (GO:0048617)	2.63541884
77	eyelid development in camera-type eye (GO:0061029)	2.57759775
78	membrane raft organization (GO:0031579)	2.54113054
79	viral transcription (GO:0019083)	2.53417902
80	regulation of transcription involved in cell fate commitment (GO:0060850)	2.52581864
81	mRNA transcription from RNA polymerase II promoter (GO:0042789)	2.49816581
82	chronic inflammatory response (GO:0002544)	2.48647387
83	renal system development (GO:0072001)	2.47934660
84	regulation of keratinocyte proliferation (GO:0010837)	2.47833259
85	regulation of tight junction assembly (GO:2000810)	2.44503072
86	regulation of vitamin D biosynthetic process (GO:0060556)	2.40179806
87	proline metabolic process (GO:0006560)	2.38888037
88	ncRNA 3-end processing (GO:0043628)	2.38262583
89	translational termination (GO:0006415)	2.36390931
90	positive regulation of glomerulus development (GO:0090193)	2.35605303
91	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.35459116
92	viral protein processing (GO:0019082)	2.30881644
93	cellular modified amino acid catabolic process (GO:0042219)	2.28474585
94	regulation of interleukin-17 production (GO:0032660)	2.26778930
95	virion assembly (GO:0019068)	2.24871845
96	establishment of skin barrier (GO:0061436)	16.0064447
97	regulation of water loss via skin (GO:0033561)	13.8949594
98	keratinocyte differentiation (GO:0030216)	13.7089518
99	peptide cross-linking (GO:0018149)	11.5027971
100	epidermal cell differentiation (GO:0009913)	10.9436337

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	6.39892872
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.98282435
3	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.97788153
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.74150971
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.21108141
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.11685425
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.10115219
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.07221658
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.64052121
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.52801612
11	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.50495696
12	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.44897556
13	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.44897556
14	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.31952521
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.2714358
16	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.83500656
17	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.76442683
18	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.76272921
19	TP63_23658742_ChIP-Seq_EP156T_Human	1.73697191
20	TP63_22573176_ChIP-Seq_HFKS_Human	1.72900053
21	SOX2_20726797_ChIP-Seq_SW620_Human	1.68712070
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.66379523
23	ERG_20517297_ChIP-Seq_VCAP_Human	1.65279333
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64876277
25	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.63041493
26	ATF3_27146783_Chip-Seq_COLON_Human	1.60196773
27	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.59353711
28	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.55847308
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53847180
30	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.52723400
31	EGR1_19032775_ChIP-ChIP_M12_Human	1.50988903
32	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.49228707
33	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.46587204
34	KLF5_25053715_ChIP-Seq_YYC3_Human	1.43952567
35	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.42959675
36	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.37838032
37	RACK7_27058665_Chip-Seq_MCF-7_Human	1.36828310
38	CTCF_27219007_Chip-Seq_Bcells_Human	1.27329507
39	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.27312048
40	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.27305624
41	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.23356232
42	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21742351
43	SMC4_20622854_ChIP-Seq_HELA_Human	1.21187161
44	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.19029524
45	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.15789304
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15205125
47	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.14852446
48	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.12923117
49	CTCF_20526341_ChIP-Seq_ESCs_Human	1.11297583
50	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07767711
51	RXR_22108803_ChIP-Seq_LS180_Human	1.07672915
52	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07517506
53	CJUN_26792858_Chip-Seq_BT549_Human	1.06964065
54	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.05558064
55	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04644342
56	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.03888165
57	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.02623488
58	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.02394748
59	ELF5_23300383_ChIP-Seq_T47D_Human	1.02391630
60	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00716974
61	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.98508602
62	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97380534
63	GATA6_25053715_ChIP-Seq_YYC3_Human	0.93530997
64	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92751452
65	BCOR_27268052_Chip-Seq_Bcells_Human	0.91665268
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90457590
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.89404146
68	E2F1_20622854_ChIP-Seq_HELA_Human	0.86164109
69	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.85884127
70	AHR_22903824_ChIP-Seq_MCF-7_Human	0.84255103
71	TP53_16413492_ChIP-PET_HCT116_Human	0.83212800
72	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.80756066
73	VDR_22108803_ChIP-Seq_LS180_Human	0.80503995
74	RBPJ_21746931_ChIP-Seq_IB4_Human	0.80168802
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.79739482
76	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.79471298
77	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.78224247
78	SPI1_20517297_ChIP-Seq_HL60_Human	0.77718036
79	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.76485681
80	BCL6_27268052_Chip-Seq_Bcells_Human	0.76470761
81	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.76079215
82	CREB1_26743006_Chip-Seq_LNCaP_Human	0.75808702
83	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.75031805
84	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.73638955
85	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.73039164
86	ERA_21632823_ChIP-Seq_H3396_Human	0.72684595
87	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.71613810
88	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.68804316
89	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.68316108
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.68311264
91	NCOR_22424771_ChIP-Seq_293T_Human	0.68190710
92	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.68070800
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.67759314
94	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.67555674
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.67038858
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.66798234
97	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.66783134
98	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.66503915
99	LXR_22292898_ChIP-Seq_THP-1_Human	0.65562780
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.65219055

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	9.40695648
2	MP0010234_abnormal_vibrissa_follicle	8.21515846
3	MP0005275_abnormal_skin_tensile	6.63093944
4	MP0005501_abnormal_skin_physiology	5.27027813
5	MP0000579_abnormal_nail_morphology	4.53004597
6	MP0010678_abnormal_skin_adnexa	3.01767753
7	MP0001216_abnormal_epidermal_layer	3.00189093
8	MP0003941_abnormal_skin_development	2.89253741
9	MP0003453_abnormal_keratinocyte_physiol	2.85342213
10	MP0004381_abnormal_hair_follicle	2.75014972
11	MP0002098_abnormal_vibrissa_morphology	2.72131723
12	MP0010771_integument_phenotype	2.64374240
13	MP0009379_abnormal_foot_pigmentation	2.60314325
14	MP0003878_abnormal_ear_physiology	2.53716081
15	MP0005377_hearing/vestibular/ear_phenot	2.53716081
16	MP0004885_abnormal_endolymph	2.26388221
17	MP0002060_abnormal_skin_morphology	2.21915309
18	MP0000467_abnormal_esophagus_morphology	2.19134043
19	MP0000377_abnormal_hair_follicle	2.04205129
20	MP0004947_skin_inflammation	2.02759210
21	MP0000383_abnormal_hair_follicle	1.88207179
22	MP0005409_darkened_coat_color	1.78740783
23	MP0004264_abnormal_extraembryonic_tissu	1.62320430
24	MP0003191_abnormal_cellular_cholesterol	1.58872508
25	MP0000762_abnormal_tongue_morphology	1.57553029
26	MP0004043_abnormal_pH_regulation	1.50546763
27	MP0002095_abnormal_skin_pigmentation	1.49551175
28	MP0000647_abnormal_sebaceous_gland	1.39787080
29	MP0009931_abnormal_skin_appearance	1.38485359
30	MP0004782_abnormal_surfactant_physiolog	1.36449386
31	MP0000566_synostosis	1.35557822
32	MP0000367_abnormal_coat/_hair	1.22802981
33	MP0010352_gastrointestinal_tract_polyps	1.19248881
34	MP0000427_abnormal_hair_cycle	1.18385334
35	MP0001191_abnormal_skin_condition	1.17354137
36	MP0001851_eye_inflammation	1.14567588
37	MP0001188_hyperpigmentation	1.12165874
38	MP0000465_gastrointestinal_hemorrhage	1.11090544
39	MP0003315_abnormal_perineum_morphology	1.06885819
40	MP0004185_abnormal_adipocyte_glucose	0.96688451
41	MP0005503_abnormal_tendon_morphology	0.96214846
42	MP0003566_abnormal_cell_adhesion	0.91222452
43	MP0003705_abnormal_hypodermis_morpholog	0.88834528
44	MP0002877_abnormal_melanocyte_morpholog	0.85722781
45	MP0003011_delayed_dark_adaptation	0.83223360
46	MP0000372_irregular_coat_pigmentation	0.79932252
47	MP0005023_abnormal_wound_healing	0.78125856
48	MP0001243_abnormal_dermal_layer	0.75694851
49	MP0005174_abnormal_tail_pigmentation	0.74191655
50	MP0003806_abnormal_nucleotide_metabolis	0.69706246
51	MP0009333_abnormal_splenocyte_physiolog	0.68790050
52	MP0001784_abnormal_fluid_regulation	0.67931319
53	MP0002177_abnormal_outer_ear	0.63979328
54	MP0009053_abnormal_anal_canal	0.60909650
55	MP0000678_abnormal_parathyroid_gland	0.60089862
56	MP0000015_abnormal_ear_pigmentation	0.57836995
57	MP0008789_abnormal_olfactory_epithelium	0.57450863
58	MP0005084_abnormal_gallbladder_morpholo	0.55438093
59	MP0002928_abnormal_bile_duct	0.54136149
60	MP0003136_yellow_coat_color	0.51498345
61	MP0003638_abnormal_response/metabolism_	0.51438731
62	MP0002277_abnormal_respiratory_mucosa	0.49503438
63	MP0005408_hypopigmentation	0.48155203
64	MP0003950_abnormal_plasma_membrane	0.47688994
65	MP0003763_abnormal_thymus_physiology	0.46210662
66	MP0002234_abnormal_pharynx_morphology	0.44662340
67	MP0000627_abnormal_mammary_gland	0.44631127
68	MP0004858_abnormal_nervous_system	0.43979537
69	MP0005171_absent_coat_pigmentation	0.43024435
70	MP0005075_abnormal_melanosome_morpholog	0.42392757
71	MP0010030_abnormal_orbit_morphology	0.40128500
72	MP0001186_pigmentation_phenotype	0.38018722
73	MP0000685_abnormal_immune_system	0.34120298
74	MP0005394_taste/olfaction_phenotype	0.32820424
75	MP0005499_abnormal_olfactory_system	0.32820424
76	MP0008004_abnormal_stomach_pH	0.32783907
77	MP0004019_abnormal_vitamin_homeostasis	0.32566935
78	MP0000750_abnormal_muscle_regeneration	0.32348392
79	MP0001485_abnormal_pinna_reflex	0.31183005
80	MP0003755_abnormal_palate_morphology	0.30009090
81	MP0001853_heart_inflammation	0.29335864
82	MP0005332_abnormal_amino_acid	0.28419592
83	MP0001340_abnormal_eyelid_morphology	0.28122289
84	MP0001756_abnormal_urination	0.27411967
85	MP0003828_pulmonary_edema	0.27284031
86	MP0005193_abnormal_anterior_eye	0.24431865
87	MP0000470_abnormal_stomach_morphology	0.23027545
88	MP0005508_abnormal_skeleton_morphology	0.22964153
89	MP0000371_diluted_coat_color	0.20988952
90	MP0002111_abnormal_tail_morphology	0.20260091
91	MP0009780_abnormal_chondrocyte_physiolo	0.18983579
92	MP0001502_abnormal_circadian_rhythm	0.18587402
93	MP0005375_adipose_tissue_phenotype	0.18037992
94	MP0001919_abnormal_reproductive_system	0.17207591
95	MP0005666_abnormal_adipose_tissue	0.16654486
96	MP0003646_muscle_fatigue	0.16643233
97	MP0002249_abnormal_larynx_morphology	0.16052418
98	MP0002075_abnormal_coat/hair_pigmentati	0.15941307
99	MP0001765_abnormal_ion_homeostasis	0.15089223
100	MP0002108_abnormal_muscle_morphology	0.14545628

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.00816615
2	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	8.44635997
3	Palmoplantar hyperkeratosis (HP:0000972)	8.27371743
4	Congenital ichthyosiform erythroderma (HP:0007431)	8.04640267
5	Erythroderma (HP:0001019)	7.92008163
6	Palmar hyperkeratosis (HP:0010765)	7.84995936
7	Oral leukoplakia (HP:0002745)	7.57996689
8	Plantar hyperkeratosis (HP:0007556)	6.77995762
9	Alopecia of scalp (HP:0002293)	6.42785740
10	Erythema (HP:0010783)	6.14736137
11	Parakeratosis (HP:0001036)	5.94526770
12	Onycholysis (HP:0001806)	5.60232682
13	Hypotrichosis (HP:0001006)	5.50477138
14	Corneal erosion (HP:0200020)	5.14054018
15	Thick nail (HP:0001805)	5.12319659
16	Abnormality of the axillary hair (HP:0100134)	5.10455954
17	Abnormality of secondary sexual hair (HP:0009888)	5.10455954
18	Fragile nails (HP:0001808)	4.92392209
19	Pustule (HP:0200039)	4.25846705
20	Right ventricular cardiomyopathy (HP:0011663)	4.10004354
21	Palmoplantar keratoderma (HP:0000982)	4.06728601
22	Hypohidrosis (HP:0000966)	3.92867680
23	Ectropion (HP:0000656)	3.79979312
24	Nail dystrophy (HP:0008404)	3.67487980
25	Eczematoid dermatitis (HP:0000976)	3.61875239
26	Gangrene (HP:0100758)	3.59708120
27	Lip pit (HP:0100267)	3.53729328
28	Woolly hair (HP:0002224)	3.46917825
29	Sparse scalp hair (HP:0002209)	3.45100661
30	Sparse eyelashes (HP:0000653)	3.38884496
31	Absent eyelashes (HP:0000561)	3.10749704
32	Absent hair (HP:0002298)	3.01834771
33	Brittle hair (HP:0002299)	2.99844662
34	Follicular hyperkeratosis (HP:0007502)	2.96130959
35	Abnormal blistering of the skin (HP:0008066)	2.94555100
36	Furrowed tongue (HP:0000221)	2.86194784
37	Conjunctival hamartoma (HP:0100780)	2.84905866
38	Hydroureter (HP:0000072)	2.77838476
39	Pruritus (HP:0000989)	2.69661834
40	Villous atrophy (HP:0011473)	2.65876364
41	Abnormality of small intestinal villus morphology (HP:0011472)	2.65876364
42	Abnormality of the salivary glands (HP:0010286)	2.46051777
43	Split foot (HP:0001839)	2.42915102
44	Dehydration (HP:0001944)	2.40717689
45	Abnormality of placental membranes (HP:0011409)	2.39208593
46	Amniotic constriction ring (HP:0009775)	2.39208593
47	Urticaria (HP:0001025)	2.31644977
48	Hypergammaglobulinemia (HP:0010702)	2.27899746
49	Blepharitis (HP:0000498)	2.17628394
50	Acanthosis nigricans (HP:0000956)	2.15648283
51	Lack of skin elasticity (HP:0100679)	2.15439364
52	Hydroxyprolinuria (HP:0003080)	2.14913771
53	Abnormality of proline metabolism (HP:0010907)	2.14913771
54	Abnormality of the dental root (HP:0006486)	2.12999234
55	Taurodontia (HP:0000679)	2.12999234
56	Abnormality of permanent molar morphology (HP:0011071)	2.12999234
57	Hyperhidrosis (HP:0000975)	2.11865005
58	Corneal dystrophy (HP:0001131)	2.11820696
59	Multifactorial inheritance (HP:0001426)	2.07545318
60	Laryngomalacia (HP:0001601)	2.03948062
61	Abnormality of molar (HP:0011077)	2.01162938
62	Abnormality of molar morphology (HP:0011070)	2.01162938
63	Abnormality of nail color (HP:0100643)	11.4579934
64	Ridged nail (HP:0001807)	1.99479514
65	Milia (HP:0001056)	1.94367590
66	Abnormality of the dental pulp (HP:0006479)	1.90432805
67	Abnormality of hair growth rate (HP:0011363)	1.90253866
68	Slow-growing hair (HP:0002217)	1.90253866
69	Autoamputation (HP:0001218)	1.86831156
70	Dry skin (HP:0000958)	1.86250743
71	Recurrent corneal erosions (HP:0000495)	1.86170699
72	Oligodontia (HP:0000677)	1.78796715
73	Hypoplastic labia majora (HP:0000059)	1.77713948
74	Dry hair (HP:0011359)	1.75728275
75	Natal tooth (HP:0000695)	1.72604591
76	Fine hair (HP:0002213)	1.71609384
77	Paralysis (HP:0003470)	1.71360923
78	Abnormal hair laboratory examination (HP:0003328)	1.69883305
79	Pili torti (HP:0003777)	1.68795438
80	Sepsis (HP:0100806)	1.67852953
81	Anonychia (HP:0001798)	1.66207263
82	Skin ulcer (HP:0200042)	1.65704942
83	Carious teeth (HP:0000670)	1.61764436
84	Abnormality of the labia majora (HP:0012881)	1.60607003
85	Conical tooth (HP:0000698)	1.58749159
86	Hamartoma of the eye (HP:0010568)	1.57761452
87	Verrucae (HP:0200043)	1.55433959
88	Papilloma (HP:0012740)	1.55433959
89	Nasolacrimal duct obstruction (HP:0000579)	1.54493695
90	Hyporeflexia of lower limbs (HP:0002600)	1.54330288
91	Selective tooth agenesis (HP:0001592)	1.53736195
92	Popliteal pterygium (HP:0009756)	1.52911177
93	Recurrent bacterial skin infections (HP:0005406)	1.52644198
94	Absent hand (HP:0004050)	1.47630754
95	Abnormality of the fingernails (HP:0001231)	1.46109316
96	Xerostomia (HP:0000217)	1.45245059
97	Seborrheic dermatitis (HP:0001051)	1.43975843
98	Nonprogressive disorder (HP:0003680)	1.43567376
99	Hypoplastic toenails (HP:0001800)	1.41082599
100	Squamous cell carcinoma (HP:0002860)	1.40767958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	8.98621944
2	LATS2	5.05820918
3	STK24	3.76436196
4	MAP3K3	2.99248008
5	TGFBR1	2.89741792
6	MAPKAPK3	2.31444231
7	NME1	2.24506743
8	MST4	2.21877882
9	RIPK1	2.16301068
10	MAP3K2	2.07762901
11	IRAK3	2.05579536
12	MAP3K12	2.01074342
13	FGFR1	1.85067245
14	NME2	1.72254385
15	MAP3K9	1.71933321
16	ERN1	1.71352643
17	MARK3	1.65285095
18	GRK6	1.51929079
19	FER	1.49954077
20	RPS6KB2	1.42944572
21	TRPM7	1.35630943
22	SGK494	1.34602302
23	SGK223	1.34602302
24	LATS1	1.09851958
25	ABL2	1.07474397
26	CDK12	1.06939206
27	MYLK	1.05724059
28	ILK	1.05505031
29	DMPK	1.04777060
30	MAP3K6	1.02872673
31	MST1R	1.01004287
32	STK3	0.99844014
33	IKBKE	0.89326591
34	PTK2	0.86081298
35	MAP3K1	0.85129058
36	TAOK1	0.83437758
37	PIK3CG	0.81758718
38	IKBKB	0.80707807
39	IRAK2	0.79903905
40	GSK3A	0.78979002
41	TBK1	0.76635361
42	MET	0.74473934
43	WNK1	0.72884396
44	IRAK1	0.71057636
45	PRKCI	0.70348317
46	TAOK3	0.68236811
47	RPS6KB1	0.67977800
48	AURKB	0.66737659
49	SIK1	0.65427777
50	TGFBR2	0.65155880
51	BCR	0.64812159
52	ADRBK1	0.63957851
53	TLK1	0.63864018
54	ERBB3	0.63772066
55	MAPK7	0.63034218
56	FGFR3	0.62494305
57	KIT	0.62065783
58	LRRK2	0.58751548
59	EPHA3	0.58638523
60	FLT3	0.58098496
61	TESK1	0.55743919
62	PBK	0.51839300
63	MAPKAPK2	0.50871152
64	PIM2	0.50814440
65	BMPR2	0.49981254
66	CDK7	0.49719547
67	SGK2	0.47812281
68	IRAK4	0.47734680
69	STK10	0.47719037
70	MAPK15	0.45180502
71	MARK2	0.44214544
72	MAPK12	0.44114536
73	NLK	0.39629150
74	OBSCN	0.39347042
75	PDGFRB	0.39261777
76	CSNK1E	0.37243150
77	PRKD2	0.36753609
78	AKT2	0.35794899
79	PRKD1	0.35386353
80	SGK3	0.34679434
81	MTOR	0.32833934
82	RPS6KA1	0.32658579
83	PRKCE	0.31290176
84	PINK1	0.27569780
85	SGK1	0.26919517
86	MAP4K1	0.26843806
87	GRK7	0.26132673
88	NTRK2	0.25828856
89	RPS6KA6	0.23985162
90	RPS6KL1	0.23914618
91	RPS6KC1	0.23914618
92	IGF1R	0.23669603
93	GRK5	0.23463546
94	PDPK1	0.23122535
95	MATK	0.20658885
96	PTK6	0.20298258
97	CSNK2A2	0.20181516
98	CSNK1A1	0.16974323
99	ABL1	0.16251023
100	TRIB3	0.16221772

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	5.49673256
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.39747614
3	Arachidonic acid metabolism_Homo sapiens_hsa00590	3.78034347
4	Ribosome_Homo sapiens_hsa03010	3.64196801
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.74538833
6	Phototransduction_Homo sapiens_hsa04744	2.11864225
7	Sphingolipid metabolism_Homo sapiens_hsa00600	1.76308490
8	Circadian rhythm_Homo sapiens_hsa04710	1.68978031
9	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68887728
10	GnRH signaling pathway_Homo sapiens_hsa04912	1.62570398
11	Histidine metabolism_Homo sapiens_hsa00340	1.59992905
12	Sulfur relay system_Homo sapiens_hsa04122	1.55071117
13	Salivary secretion_Homo sapiens_hsa04970	1.53477847
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.47224275
15	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.41454252
16	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.40019589
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.38147353
18	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.37804881
19	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.37161750
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.34977401
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.32704822
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.24441642
23	RNA polymerase_Homo sapiens_hsa03020	1.24250642
24	Tight junction_Homo sapiens_hsa04530	1.20881372
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20636224
26	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.20142142
27	Adherens junction_Homo sapiens_hsa04520	1.19572288
28	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.16183002
29	Asthma_Homo sapiens_hsa05310	1.13489162
30	Amoebiasis_Homo sapiens_hsa05146	1.13193700
31	Ras signaling pathway_Homo sapiens_hsa04014	1.11528885
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10817747
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07085351
34	VEGF signaling pathway_Homo sapiens_hsa04370	1.04222109
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.02122066
36	Endocytosis_Homo sapiens_hsa04144	1.01281071
37	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.00003653
38	Alzheimers disease_Homo sapiens_hsa05010	0.95669732
39	Pertussis_Homo sapiens_hsa05133	0.92527258
40	Olfactory transduction_Homo sapiens_hsa04740	0.92346500
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.90826832
42	Renin secretion_Homo sapiens_hsa04924	0.89351938
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87194369
44	Long-term depression_Homo sapiens_hsa04730	0.86299496
45	Retinol metabolism_Homo sapiens_hsa00830	0.83976486
46	Serotonergic synapse_Homo sapiens_hsa04726	0.83246936
47	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80330730
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.79569414
49	Renin-angiotensin system_Homo sapiens_hsa04614	0.77821079
50	Salmonella infection_Homo sapiens_hsa05132	0.72491333
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71814054
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71731014
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70600914
54	ECM-receptor interaction_Homo sapiens_hsa04512	0.70572903
55	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.70356400
56	Parkinsons disease_Homo sapiens_hsa05012	0.69790512
57	Huntingtons disease_Homo sapiens_hsa05016	0.68346435
58	ABC transporters_Homo sapiens_hsa02010	0.65346944
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64512734
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.63125463
61	Proteasome_Homo sapiens_hsa03050	0.60715391
62	p53 signaling pathway_Homo sapiens_hsa04115	0.60624296
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57594420
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56918297
65	Thyroid cancer_Homo sapiens_hsa05216	0.56587818
66	Mineral absorption_Homo sapiens_hsa04978	0.56466382
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.55731430
68	Insulin signaling pathway_Homo sapiens_hsa04910	0.54593514
69	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.53727921
70	Malaria_Homo sapiens_hsa05144	0.53572542
71	Hepatitis C_Homo sapiens_hsa05160	0.53129884
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52158067
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51741437
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51455376
75	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.51045797
76	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.50948799
77	MAPK signaling pathway_Homo sapiens_hsa04010	0.50803713
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49967124
79	Legionellosis_Homo sapiens_hsa05134	0.49278388
80	Influenza A_Homo sapiens_hsa05164	0.48802995
81	Melanogenesis_Homo sapiens_hsa04916	0.48334728
82	Shigellosis_Homo sapiens_hsa05131	0.47975319
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47361962
84	Toxoplasmosis_Homo sapiens_hsa05145	0.45381927
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45319490
86	Renal cell carcinoma_Homo sapiens_hsa05211	0.44492481
87	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.44040515
88	Tuberculosis_Homo sapiens_hsa05152	0.44000322
89	Glioma_Homo sapiens_hsa05214	0.42784329
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41357231
91	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.39650412
92	Phagosome_Homo sapiens_hsa04145	0.38529647
93	Long-term potentiation_Homo sapiens_hsa04720	0.38495888
94	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36349728
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.34981221
96	Bladder cancer_Homo sapiens_hsa05219	0.34861221
97	Pancreatic secretion_Homo sapiens_hsa04972	0.33962728
98	Estrogen signaling pathway_Homo sapiens_hsa04915	0.33705112
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32471712
100	Sulfur metabolism_Homo sapiens_hsa00920	0.31677113

FAM25A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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