FAM25BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.64686675
2desmosome organization (GO:0002934)9.03709307
3keratinocyte proliferation (GO:0043616)8.13958266
4epidermal cell differentiation (GO:0009913)7.97786330
5multicellular organismal water homeostasis (GO:0050891)7.47998737
6peptide cross-linking (GO:0018149)7.10362518
7water homeostasis (GO:0030104)6.32686336
8keratinocyte development (GO:0003334)6.30186786
9epidermis development (GO:0008544)6.04236660
10molting cycle (GO:0042303)5.87695632
11hair cycle (GO:0042633)5.87695632
12positive regulation of glomerulus development (GO:0090193)5.65458409
13positive regulation of cellular amide metabolic process (GO:0034250)5.57271034
14gap junction assembly (GO:0016264)4.94545263
15regulation of transforming growth factor beta1 production (GO:0032908)4.91150419
16polarized epithelial cell differentiation (GO:0030859)4.56399564
17regulation of cell proliferation involved in kidney development (GO:1901722)4.36376062
18long-chain fatty acid biosynthetic process (GO:0042759)4.31667351
19bundle of His cell to Purkinje myocyte communication (GO:0086069)4.28301832
20positive regulation of interleukin-8 secretion (GO:2000484)4.17195297
21ectoderm development (GO:0007398)4.01044721
22phosphatidylinositol acyl-chain remodeling (GO:0036149)3.96717719
23negative regulation of cAMP-mediated signaling (GO:0043951)3.96639068
24multicellular organism reproduction (GO:0032504)3.95016296
25defense response to Gram-negative bacterium (GO:0050829)3.88345084
26positive regulation of T-helper 1 type immune response (GO:0002827)3.85342158
27piRNA metabolic process (GO:0034587)3.81801767
28establishment of tissue polarity (GO:0007164)3.81740289
29establishment of planar polarity (GO:0001736)3.81740289
30lateral sprouting from an epithelium (GO:0060601)3.80837490
31epithelial cell maturation (GO:0002070)3.80150906
32cellular response to arsenic-containing substance (GO:0071243)3.76684007
33phosphatidylserine acyl-chain remodeling (GO:0036150)3.71010981
34defense response to fungus (GO:0050832)3.70916170
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70576596
36chemical homeostasis within a tissue (GO:0048875)3.66445701
37regulation of keratinocyte proliferation (GO:0010837)3.63725606
38regulation of glomerulus development (GO:0090192)3.63162081
39negative regulation of keratinocyte proliferation (GO:0010839)3.61818313
40regulation of neuron projection regeneration (GO:0070570)3.61596311
41regulation of axon regeneration (GO:0048679)3.61596311
42positive regulation of p38MAPK cascade (GO:1900745)3.59712995
43regulation of keratinocyte differentiation (GO:0045616)3.59690222
44spermatid development (GO:0007286)3.54061952
45lipoxygenase pathway (GO:0019372)3.52271173
46positive regulation of humoral immune response (GO:0002922)3.48196639
47intermediate filament organization (GO:0045109)3.45440820
48male meiosis (GO:0007140)3.45405209
49regulation of acrosome reaction (GO:0060046)3.45351483
50regulation of p38MAPK cascade (GO:1900744)3.44732489
51negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.40975737
52atrial cardiac muscle cell action potential (GO:0086014)3.40414977
53sperm motility (GO:0030317)3.39216708
54intestinal epithelial cell development (GO:0060576)3.33410598
55skeletal muscle tissue regeneration (GO:0043403)3.33323252
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32242363
57acrosome reaction (GO:0007340)3.31842389
58intermediate filament cytoskeleton organization (GO:0045104)3.31145427
59regulation of oxidative phosphorylation (GO:0002082)3.30445754
60antimicrobial humoral response (GO:0019730)3.27120875
61endothelium development (GO:0003158)3.26966272
62surfactant homeostasis (GO:0043129)3.24352499
63hair cell differentiation (GO:0035315)3.20111896
64intermediate filament-based process (GO:0045103)3.19605544
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.19146541
66regulation of glomerular filtration (GO:0003093)3.11332308
67fatty acid elongation (GO:0030497)3.10906905
68regulation of oxidative stress-induced neuron death (GO:1903203)3.10641478
69negative regulation of interleukin-17 production (GO:0032700)3.09222659
70phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.08589951
71positive regulation of meiotic cell cycle (GO:0051446)3.05759537
72negative regulation of epidermal cell differentiation (GO:0045605)3.05059610
73purine ribonucleotide transport (GO:0015868)3.04297377
74fusion of sperm to egg plasma membrane (GO:0007342)3.04215443
75regulation of interleukin-8 secretion (GO:2000482)3.03578226
76regulation of phosphoprotein phosphatase activity (GO:0043666)3.03270019
77regulation of epidermis development (GO:0045682)3.03089569
78keratinization (GO:0031424)21.1637702
79negative regulation of interferon-gamma production (GO:0032689)2.99827081
80adenine nucleotide transport (GO:0051503)2.97388945
81positive regulation of cholesterol efflux (GO:0010875)2.96731389
82hemidesmosome assembly (GO:0031581)2.96530567
83imidazole-containing compound metabolic process (GO:0052803)2.95340840
84phosphatidylcholine acyl-chain remodeling (GO:0036151)2.88454868
85regulation of T-helper 1 type immune response (GO:0002825)2.88454728
86ether lipid metabolic process (GO:0046485)2.88387187
87motile cilium assembly (GO:0044458)2.87637640
88pyrimidine dimer repair (GO:0006290)2.84200746
89negative regulation of heart growth (GO:0061117)2.80919583
90negative regulation of cardiac muscle tissue growth (GO:0055022)2.80919583
91epithelium development (GO:0060429)2.80859301
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80677636
93regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.79491832
94positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.74219543
95regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.74219543
96cornea development in camera-type eye (GO:0061303)2.73580091
97positive regulation of catecholamine secretion (GO:0033605)2.73270004
98reproduction (GO:0000003)2.73239332
99establishment of skin barrier (GO:0061436)14.0290188
100regulation of water loss via skin (GO:0033561)11.8049283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.15504617
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.81897599
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.57248383
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.93154757
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.40344239
6P63_26484246_Chip-Seq_KERATINOCYTES_Human2.95329507
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.83987987
8IGF1R_20145208_ChIP-Seq_DFB_Human2.41264875
9RXR_22108803_ChIP-Seq_LS180_Human2.29178013
10TP63_23658742_ChIP-Seq_EP156T_Human2.23687375
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10951117
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03204853
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.03204853
14FUS_26573619_Chip-Seq_HEK293_Human1.95924227
15TP53_18474530_ChIP-ChIP_U2OS_Human1.85392689
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.83161607
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73328791
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73328791
19AHR_22903824_ChIP-Seq_MCF-7_Human1.73222514
20VDR_22108803_ChIP-Seq_LS180_Human1.73199962
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70901492
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65706624
23SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62432193
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62305212
25NANOG_20526341_ChIP-Seq_ESCs_Human1.56117291
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.53508193
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50321458
28CBP_20019798_ChIP-Seq_JUKART_Human1.50321458
29CJUN_26792858_Chip-Seq_BT549_Human1.42793822
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40756044
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40629851
32GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.37193728
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33458091
34TAF15_26573619_Chip-Seq_HEK293_Human1.32584240
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31451483
36AR_25329375_ChIP-Seq_VCAP_Human1.30707327
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30669054
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29356066
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28006521
40ERG_20517297_ChIP-Seq_VCAP_Human1.27643702
41GATA6_21074721_ChIP-Seq_CACO-2_Human1.27400407
42TP63_22573176_ChIP-Seq_HFKS_Human1.26745898
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.26490481
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23886280
45SOX2_19829295_ChIP-Seq_ESCs_Human1.23151850
46NANOG_19829295_ChIP-Seq_ESCs_Human1.23151850
47P300_19829295_ChIP-Seq_ESCs_Human1.23143947
48CDX2_22108803_ChIP-Seq_LS180_Human1.22849810
49EGR1_19032775_ChIP-ChIP_M12_Human1.22098124
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20951212
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20617563
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20557906
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20557906
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.18693061
55HTT_18923047_ChIP-ChIP_STHdh_Human1.16500477
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16396027
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14872523
58SMAD4_21799915_ChIP-Seq_A2780_Human1.14464173
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13129463
60AR_21572438_ChIP-Seq_LNCaP_Human1.11556913
61GATA3_24758297_ChIP-Seq_MCF-7_Human1.10373652
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08993943
63BCAT_22108803_ChIP-Seq_LS180_Human1.07847524
64ER_23166858_ChIP-Seq_MCF-7_Human1.07807359
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07430448
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04212124
67NCOR_22424771_ChIP-Seq_293T_Human1.02560484
68OCT1_27270436_Chip-Seq_PROSTATE_Human1.00096119
69CEBPB_22108803_ChIP-Seq_LS180_Human0.99435117
70FOXH1_21741376_ChIP-Seq_EPCs_Human0.99040846
71GATA3_21878914_ChIP-Seq_MCF-7_Human0.98577441
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98029013
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96517067
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96246905
75TCF4_22108803_ChIP-Seq_LS180_Human0.96212659
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96056405
77TBL1_22424771_ChIP-Seq_293T_Human0.96043356
78PIAS1_25552417_ChIP-Seq_VCAP_Human0.95846277
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94229768
80RBPJ_21746931_ChIP-Seq_IB4_Human0.94156610
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93938475
82CTCF_27219007_Chip-Seq_Bcells_Human0.93836711
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93539624
84GATA4_25053715_ChIP-Seq_YYC3_Human0.93240176
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93195202
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93099351
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92997484
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.92881523
89P53_21459846_ChIP-Seq_SAOS-2_Human0.91678953
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91196090
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91193618
92RAC3_21632823_ChIP-Seq_H3396_Human0.90406261
93ERA_21632823_ChIP-Seq_H3396_Human0.90272653
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90091355
95P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89134041
96HNFA_21074721_ChIP-Seq_CACO-2_Human0.88274247
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87921783
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87735892
99CBP_21632823_ChIP-Seq_H3396_Human0.87660612
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86546289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.49287157
2MP0010234_abnormal_vibrissa_follicle8.12879972
3MP0005501_abnormal_skin_physiology5.23210992
4MP0005275_abnormal_skin_tensile5.12671056
5MP0000579_abnormal_nail_morphology4.04923486
6MP0003941_abnormal_skin_development3.75365646
7MP0010678_abnormal_skin_adnexa3.45206566
8MP0010771_integument_phenotype2.67208655
9MP0001216_abnormal_epidermal_layer2.63376623
10MP0003453_abnormal_keratinocyte_physiol2.59969649
11MP0004381_abnormal_hair_follicle2.44709316
12MP0000383_abnormal_hair_follicle2.27318640
13MP0002098_abnormal_vibrissa_morphology2.23152894
14MP0000566_synostosis2.15481677
15MP0005410_abnormal_fertilization2.11122320
16MP0004782_abnormal_surfactant_physiolog2.08414003
17MP0008004_abnormal_stomach_pH1.84228804
18MP0001188_hyperpigmentation1.79806605
19MP0003191_abnormal_cellular_cholesterol1.79355774
20MP0009379_abnormal_foot_pigmentation1.77580743
21MP0002060_abnormal_skin_morphology1.73161512
22MP0000678_abnormal_parathyroid_gland1.59627799
23MP0003315_abnormal_perineum_morphology1.57701313
24MP0000377_abnormal_hair_follicle1.56712710
25MP0000427_abnormal_hair_cycle1.53298830
26MP0003950_abnormal_plasma_membrane1.51287627
27MP0004947_skin_inflammation1.46539327
28MP0005503_abnormal_tendon_morphology1.44916868
29MP0005360_urolithiasis1.44537976
30MP0004885_abnormal_endolymph1.41308498
31MP0000467_abnormal_esophagus_morphology1.33673369
32MP0003195_calcinosis1.31781138
33MP0009384_cardiac_valve_regurgitation1.26879798
34MP0003718_maternal_effect1.24578417
35MP0002160_abnormal_reproductive_system1.21673437
36MP0002095_abnormal_skin_pigmentation1.20446643
37MP0000762_abnormal_tongue_morphology1.19448344
38MP0004264_abnormal_extraembryonic_tissu1.17380464
39MP0009931_abnormal_skin_appearance1.15131932
40MP0000015_abnormal_ear_pigmentation1.10506453
41MP0001191_abnormal_skin_condition1.07703420
42MP0000367_abnormal_coat/_hair1.03748189
43MP0008057_abnormal_DNA_replication1.02139622
44MP0001984_abnormal_olfaction1.00100067
45MP0009780_abnormal_chondrocyte_physiolo0.97676652
46MP0000465_gastrointestinal_hemorrhage0.95570395
47MP0005377_hearing/vestibular/ear_phenot0.92690817
48MP0003878_abnormal_ear_physiology0.92690817
49MP0008789_abnormal_olfactory_epithelium0.88834647
50MP0001784_abnormal_fluid_regulation0.80852515
51MP0003698_abnormal_male_reproductive0.80526573
52MP0000647_abnormal_sebaceous_gland0.79270127
53MP0005394_taste/olfaction_phenotype0.79238781
54MP0005499_abnormal_olfactory_system0.79238781
55MP0005646_abnormal_pituitary_gland0.78149130
56MP0001929_abnormal_gametogenesis0.71400112
57MP0002876_abnormal_thyroid_physiology0.71135079
58MP0004043_abnormal_pH_regulation0.70224734
59MP0005389_reproductive_system_phenotype0.69127930
60MP0001501_abnormal_sleep_pattern0.68004287
61MP0001664_abnormal_digestion0.67193353
62MP0008995_early_reproductive_senescence0.64948896
63MP0009053_abnormal_anal_canal0.62696025
64MP0001853_heart_inflammation0.60482639
65MP0003011_delayed_dark_adaptation0.59094318
66MP0006072_abnormal_retinal_apoptosis0.57779868
67MP0002108_abnormal_muscle_morphology0.56406158
68MP0002009_preneoplasia0.55673450
69MP0010386_abnormal_urinary_bladder0.55576215
70MP0005409_darkened_coat_color0.55228078
71MP0003045_fibrosis0.55203580
72MP0004484_altered_response_of0.54421082
73MP0000230_abnormal_systemic_arterial0.50902945
74MP0001542_abnormal_bone_strength0.48116619
75MP0000681_abnormal_thyroid_gland0.47935913
76MP0005647_abnormal_sex_gland0.46754771
77MP0000049_abnormal_middle_ear0.46740353
78MP0002233_abnormal_nose_morphology0.44287808
79MP0003755_abnormal_palate_morphology0.44087466
80MP0002210_abnormal_sex_determination0.43031256
81MP0000627_abnormal_mammary_gland0.41341991
82MP0005174_abnormal_tail_pigmentation0.40788952
83MP0005395_other_phenotype0.40758856
84MP0001881_abnormal_mammary_gland0.39666058
85MP0001756_abnormal_urination0.38501503
86MP0001919_abnormal_reproductive_system0.38253176
87MP0001851_eye_inflammation0.36902591
88MP0002638_abnormal_pupillary_reflex0.36408927
89MP0005187_abnormal_penis_morphology0.35109778
90MP0000750_abnormal_muscle_regeneration0.34625370
91MP0003936_abnormal_reproductive_system0.33802051
92MP0002971_abnormal_brown_adipose0.33687358
93MP0002234_abnormal_pharynx_morphology0.33564351
94MP0005197_abnormal_uvea_morphology0.33410802
95MP0004197_abnormal_fetal_growth/weight/0.32814856
96MP0009278_abnormal_bone_marrow0.32717035
97MP0005023_abnormal_wound_healing0.32018424
98MP0004215_abnormal_myocardial_fiber0.30738507
99MP0002998_abnormal_bone_remodeling0.30585636
100MP0009333_abnormal_splenocyte_physiolog0.30216500

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.39313161
2Congenital ichthyosiform erythroderma (HP:0007431)7.11695977
3Palmoplantar hyperkeratosis (HP:0000972)6.82659644
4Palmar hyperkeratosis (HP:0010765)6.53971933
5Erythroderma (HP:0001019)6.51895632
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.22305096
7Plantar hyperkeratosis (HP:0007556)5.60587136
8Parakeratosis (HP:0001036)5.38829828
9Hypotrichosis (HP:0001006)5.23495303
10Abnormality of secondary sexual hair (HP:0009888)5.18793153
11Abnormality of the axillary hair (HP:0100134)5.18793153
12Thick nail (HP:0001805)4.98851939
13Erythema (HP:0010783)4.88065776
14Fragile nails (HP:0001808)4.77540095
15Oral leukoplakia (HP:0002745)4.74610789
16Onycholysis (HP:0001806)4.67711462
17Corneal erosion (HP:0200020)4.48740561
18Alopecia of scalp (HP:0002293)4.25774621
19Sparse scalp hair (HP:0002209)3.93950617
20Abnormality of the columella (HP:0009929)3.76667202
21Palmoplantar keratoderma (HP:0000982)3.76074503
22Lip pit (HP:0100267)3.71767448
23Dry hair (HP:0011359)3.71259082
24Ectropion (HP:0000656)3.67246833
25Hypohidrosis (HP:0000966)3.65933863
26Aplasia involving bones of the upper limbs (HP:0009823)3.52050980
27Aplasia of the phalanges of the hand (HP:0009802)3.52050980
28Aplasia involving bones of the extremities (HP:0009825)3.52050980
29Thyroid-stimulating hormone excess (HP:0002925)3.22578708
30Right ventricular cardiomyopathy (HP:0011663)3.20030344
31Selective tooth agenesis (HP:0001592)3.18356887
32Oligodontia (HP:0000677)3.08481706
33Long nose (HP:0003189)3.06805315
34Gangrene (HP:0100758)3.01778156
35Short middle phalanx of the 5th finger (HP:0004220)3.00308074
36Broad alveolar ridges (HP:0000187)3.00020402
37Hypoplastic labia majora (HP:0000059)2.79041524
38Nail dystrophy (HP:0008404)2.78612225
39Abnormality of the dental root (HP:0006486)2.77553936
40Taurodontia (HP:0000679)2.77553936
41Abnormality of permanent molar morphology (HP:0011071)2.77553936
42Woolly hair (HP:0002224)2.68527309
43Absent eyelashes (HP:0000561)2.62357646
44Abnormality of molar morphology (HP:0011070)2.61576243
45Abnormality of molar (HP:0011077)2.61576243
46Follicular hyperkeratosis (HP:0007502)2.52556123
47Abnormality of the labia majora (HP:0012881)2.50956866
48Abnormality of the salivary glands (HP:0010286)2.50331446
49Slow-growing hair (HP:0002217)2.49377510
50Abnormality of hair growth rate (HP:0011363)2.49377510
51Conjunctival hamartoma (HP:0100780)2.47830284
52Pustule (HP:0200039)2.47114980
53Abnormality of the dental pulp (HP:0006479)2.46421040
54Pruritus (HP:0000989)2.46191860
55Duplicated collecting system (HP:0000081)2.38391944
56Nasolacrimal duct obstruction (HP:0000579)2.29950336
57Furrowed tongue (HP:0000221)2.28440269
58Hyporeflexia of lower limbs (HP:0002600)2.27045057
59Xerostomia (HP:0000217)2.24189713
60Thickened helices (HP:0000391)2.23650686
61Median cleft lip (HP:0000161)2.20609317
62Absent hair (HP:0002298)2.19892704
63Sparse eyelashes (HP:0000653)2.19724954
64Abnormality of the renal collecting system (HP:0004742)2.18138873
65Non-midline cleft lip (HP:0100335)2.17674081
66Abnormal blistering of the skin (HP:0008066)2.16770431
67Tetraparesis (HP:0002273)2.14991154
68Hyperhidrosis (HP:0000975)2.13686384
69Abnormal hair laboratory examination (HP:0003328)2.12846263
70Sensory axonal neuropathy (HP:0003390)2.12809482
71Curly hair (HP:0002212)2.12194102
72Pili torti (HP:0003777)2.09178709
73Hypoplasia of the uterus (HP:0000013)2.06819468
74Laryngomalacia (HP:0001601)2.05373964
75Abnormality of the alveolar ridges (HP:0006477)2.05264556
76Milia (HP:0001056)2.01552217
77Brittle hair (HP:0002299)2.01021994
78Abnormality of nail color (HP:0100643)10.0918243
79Depressed nasal tip (HP:0000437)1.98658978
80Lack of skin elasticity (HP:0100679)1.97813840
81Split foot (HP:0001839)1.91805761
82Dehydration (HP:0001944)1.88557683
83Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84737235
84Conical tooth (HP:0000698)1.84680997
85Dry skin (HP:0000958)1.82544278
86Abnormality of the lacrimal duct (HP:0011481)1.75783196
87Hypoplasia of dental enamel (HP:0006297)1.74050824
88Sex reversal (HP:0012245)1.69900646
89Abnormal sex determination (HP:0012244)1.69900646
90Abnormality of the nasolacrimal system (HP:0000614)1.69247562
91Mixed hearing impairment (HP:0000410)1.67310395
92Eczematoid dermatitis (HP:0000976)1.65579263
93Carious teeth (HP:0000670)1.62679348
94Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62418155
95Aplasia cutis congenita (HP:0001057)1.61358188
96Recurrent corneal erosions (HP:0000495)1.61223598
97Corneal dystrophy (HP:0001131)1.61169638
98Labial hypoplasia (HP:0000066)1.60350634
99Fine hair (HP:0002213)1.59962457
100Hamartoma (HP:0010566)1.59846823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.44518851
2STK246.38144689
3FRK4.63723735
4EPHA24.43615763
5TGFBR13.19103973
6ADRBK23.05622664
7MARK32.79055309
8STK38L2.22660665
9MAP3K92.10315231
10DYRK32.08523448
11MOS2.06851626
12STK32.06847297
13GRK71.60575434
14IRAK11.57381030
15TGFBR21.48331549
16IRAK21.46954911
17MAPK71.46940323
18ADRBK11.40383433
19ZAK1.37889322
20ARAF1.35571475
21PRKCE1.23395439
22MAPK121.23354701
23GRK51.18558694
24IRAK31.15931733
25MAP4K21.12503788
26LATS11.02161832
27TLK10.98556165
28MAP3K20.98386961
29PRKCG0.97291552
30FGFR20.97158577
31TAOK30.97013481
32BMPR1B0.96458878
33RPS6KA50.96388932
34STK160.95670137
35SGK2230.93839084
36SGK4940.93839084
37MST1R0.91091027
38ABL20.87242421
39MAP3K10.83448006
40MYLK0.82830407
41FGFR10.81928076
42PKN10.81446875
43IKBKB0.78194710
44MAP3K30.77547415
45MAPK150.76094836
46ICK0.75748459
47IRAK40.72974089
48CDK30.71029913
49CSNK1A1L0.69859587
50TAF10.69274651
51ILK0.69179346
52PIK3CG0.67836787
53GRK10.66037853
54STK100.64689402
55EIF2AK30.63617598
56MAPKAPK50.60248369
57DMPK0.59074505
58NUAK10.58688196
59MELK0.56592649
60EPHA40.56091896
61OBSCN0.55797928
62RPS6KB10.55561327
63PIM20.55082792
64MAPKAPK30.54597465
65KIT0.51961051
66NEK90.47163976
67MET0.46904728
68STK380.46298573
69LATS20.44811742
70CASK0.43005577
71BRAF0.42600527
72PLK20.42291117
73PRKCI0.41675550
74NEK20.40641824
75CDK120.40515861
76SGK20.39053047
77PRKCQ0.37513174
78FLT30.36476389
79TIE10.35736077
80CSNK1G30.35583743
81MTOR0.33743743
82MST40.32834907
83CDK90.30190149
84TRPM70.30140367
85RET0.29986464
86SGK10.29962275
87PLK40.28942947
88CAMK10.27579340
89FER0.26975386
90CSNK1D0.26381099
91BRSK20.26183762
92ACVR1B0.24844847
93MAP2K70.24592490
94WNK10.23407077
95IKBKE0.23132327
96ABL10.23085280
97CSNK1G10.22370457
98ATM0.19839223
99AKT30.19642495
100AURKA0.18829180

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.44073384
2Linoleic acid metabolism_Homo sapiens_hsa005913.91649010
3Dorso-ventral axis formation_Homo sapiens_hsa043203.83795169
4Sphingolipid metabolism_Homo sapiens_hsa006003.17262728
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.88390773
6Ether lipid metabolism_Homo sapiens_hsa005652.77966652
7Arachidonic acid metabolism_Homo sapiens_hsa005902.71124854
8Circadian rhythm_Homo sapiens_hsa047102.50841707
9Gap junction_Homo sapiens_hsa045402.37228935
10Olfactory transduction_Homo sapiens_hsa047402.35923327
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.13004800
12Hedgehog signaling pathway_Homo sapiens_hsa043402.09806278
13Histidine metabolism_Homo sapiens_hsa003402.06743330
14Nitrogen metabolism_Homo sapiens_hsa009101.92113440
15Phototransduction_Homo sapiens_hsa047441.88972609
16Ovarian steroidogenesis_Homo sapiens_hsa049131.76468293
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.70633165
18Renin secretion_Homo sapiens_hsa049241.60378905
19ABC transporters_Homo sapiens_hsa020101.58818726
20Retinol metabolism_Homo sapiens_hsa008301.52533838
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.51613636
22Salivary secretion_Homo sapiens_hsa049701.33051673
23p53 signaling pathway_Homo sapiens_hsa041151.25258428
24Long-term depression_Homo sapiens_hsa047301.18107501
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13946070
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12624189
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08847756
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05914685
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01705199
30Serotonergic synapse_Homo sapiens_hsa047260.99919510
31Systemic lupus erythematosus_Homo sapiens_hsa053220.97539196
32Chemical carcinogenesis_Homo sapiens_hsa052040.97055385
33Choline metabolism in cancer_Homo sapiens_hsa052310.95631046
34Phagosome_Homo sapiens_hsa041450.94951997
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94155183
36Basal transcription factors_Homo sapiens_hsa030220.94116183
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90802441
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90628286
39Sphingolipid signaling pathway_Homo sapiens_hsa040710.89418714
40Staphylococcus aureus infection_Homo sapiens_hsa051500.89210682
41Oxytocin signaling pathway_Homo sapiens_hsa049210.87865349
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87082428
43Fanconi anemia pathway_Homo sapiens_hsa034600.86720371
44Arginine biosynthesis_Homo sapiens_hsa002200.83353794
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81478124
46VEGF signaling pathway_Homo sapiens_hsa043700.77049500
47Mineral absorption_Homo sapiens_hsa049780.76180297
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76058670
49Tight junction_Homo sapiens_hsa045300.75379408
50Alcoholism_Homo sapiens_hsa050340.74296187
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71779975
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71559393
53Apoptosis_Homo sapiens_hsa042100.71085333
54Glutathione metabolism_Homo sapiens_hsa004800.70861678
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69132217
56Inositol phosphate metabolism_Homo sapiens_hsa005620.68991053
57GnRH signaling pathway_Homo sapiens_hsa049120.67668183
58Pancreatic secretion_Homo sapiens_hsa049720.67295033
59Circadian entrainment_Homo sapiens_hsa047130.66221589
60Wnt signaling pathway_Homo sapiens_hsa043100.64869096
61Glutamatergic synapse_Homo sapiens_hsa047240.63136911
62MAPK signaling pathway_Homo sapiens_hsa040100.62821607
63Taste transduction_Homo sapiens_hsa047420.61074893
64Calcium signaling pathway_Homo sapiens_hsa040200.61018606
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60860278
66Platelet activation_Homo sapiens_hsa046110.56004589
67Glycerolipid metabolism_Homo sapiens_hsa005610.55332015
68Butanoate metabolism_Homo sapiens_hsa006500.54256311
69Glucagon signaling pathway_Homo sapiens_hsa049220.53835067
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52530872
71Ras signaling pathway_Homo sapiens_hsa040140.52503399
72FoxO signaling pathway_Homo sapiens_hsa040680.46332041
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46223334
74Estrogen signaling pathway_Homo sapiens_hsa049150.45976023
75Oocyte meiosis_Homo sapiens_hsa041140.45142996
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43427594
77Regulation of autophagy_Homo sapiens_hsa041400.43346359
78Collecting duct acid secretion_Homo sapiens_hsa049660.42999228
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40294059
80Gastric acid secretion_Homo sapiens_hsa049710.40279754
81Fatty acid elongation_Homo sapiens_hsa000620.40142423
82PPAR signaling pathway_Homo sapiens_hsa033200.39322042
83MicroRNAs in cancer_Homo sapiens_hsa052060.38448738
84Melanogenesis_Homo sapiens_hsa049160.37927386
85ECM-receptor interaction_Homo sapiens_hsa045120.34180039
86Amoebiasis_Homo sapiens_hsa051460.33974348
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33904814
88ErbB signaling pathway_Homo sapiens_hsa040120.33831285
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33561189
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29565299
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.29508508
92TGF-beta signaling pathway_Homo sapiens_hsa043500.28822109
93Hippo signaling pathway_Homo sapiens_hsa043900.28792961
94Phenylalanine metabolism_Homo sapiens_hsa003600.28775754
95Caffeine metabolism_Homo sapiens_hsa002320.28433604
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27756068
97Basal cell carcinoma_Homo sapiens_hsa052170.26580135
98Tyrosine metabolism_Homo sapiens_hsa003500.24247181
99Adherens junction_Homo sapiens_hsa045200.22862211
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20905698

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