FAM25C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte proliferation (GO:0043616)8.53066880
2sphingoid metabolic process (GO:0046519)7.87605554
3multicellular organismal water homeostasis (GO:0050891)7.82049365
4keratinocyte differentiation (GO:0030216)7.55209320
5long-chain fatty acid biosynthetic process (GO:0042759)7.46427513
6water homeostasis (GO:0030104)6.66033518
7sphingosine metabolic process (GO:0006670)6.59932374
8linoleic acid metabolic process (GO:0043651)6.14116260
9epidermal cell differentiation (GO:0009913)5.95503926
10viral transcription (GO:0019083)5.94334009
11diol metabolic process (GO:0034311)5.92067167
12glucosamine-containing compound catabolic process (GO:1901072)5.89864429
13interferon-gamma secretion (GO:0072643)5.69976400
14translational termination (GO:0006415)5.62387862
15regulation of cell proliferation involved in kidney development (GO:1901722)5.51738878
16regulation of phospholipase A2 activity (GO:0032429)5.50701225
17ribosomal small subunit biogenesis (GO:0042274)5.41682131
18regulation of ruffle assembly (GO:1900027)5.41302939
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.40798640
20peptide cross-linking (GO:0018149)5.39407119
21hair cycle (GO:0042633)5.31398196
22molting cycle (GO:0042303)5.31398196
23fatty acid elongation (GO:0030497)5.24134421
24positive regulation of interleukin-8 secretion (GO:2000484)5.09379424
25epidermis development (GO:0008544)5.07234185
26lipoxygenase pathway (GO:0019372)4.86343514
27hemidesmosome assembly (GO:0031581)4.84106133
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.68717912
29regulation of chemokine secretion (GO:0090196)4.67556983
30regulation of transforming growth factor beta1 production (GO:0032908)4.61191394
31cyclooxygenase pathway (GO:0019371)4.49182186
32translational elongation (GO:0006414)4.46909067
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46451832
34viral life cycle (GO:0019058)4.41258689
35protein targeting to ER (GO:0045047)4.39593254
36cotranslational protein targeting to membrane (GO:0006613)4.36977564
37cellular protein complex disassembly (GO:0043624)4.26748798
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25051761
39intermediate filament organization (GO:0045109)4.19339459
40positive regulation of glomerulus development (GO:0090193)4.15701266
41detection of bacterium (GO:0016045)4.11861580
42protein localization to endoplasmic reticulum (GO:0070972)4.11481221
43maturation of SSU-rRNA (GO:0030490)4.11053236
44prostaglandin biosynthetic process (GO:0001516)4.09889684
45prostanoid biosynthetic process (GO:0046457)4.09889684
46keratinocyte development (GO:0003334)4.09713833
47ribosomal small subunit assembly (GO:0000028)4.06694728
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04478347
49positive regulation of chemokine secretion (GO:0090197)4.03841130
50regulation of interleukin-8 secretion (GO:2000482)3.90210013
51regulation of hypersensitivity (GO:0002883)3.86226206
52phosphatidylinositol acyl-chain remodeling (GO:0036149)3.82346835
53ectoderm development (GO:0007398)3.81173998
54long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.79149047
55retinal metabolic process (GO:0042574)3.77104956
56negative regulation of stress fiber assembly (GO:0051497)3.73574935
57eyelid development in camera-type eye (GO:0061029)3.69471066
58primary alcohol catabolic process (GO:0034310)3.69003754
59chemical homeostasis within a tissue (GO:0048875)3.59212438
60cardiolipin metabolic process (GO:0032048)3.58994876
61protein complex disassembly (GO:0043241)3.53265210
62translational initiation (GO:0006413)3.53177913
63skin morphogenesis (GO:0043589)3.51565873
64detection of other organism (GO:0098543)3.36853018
65prostanoid metabolic process (GO:0006692)3.35478923
66prostaglandin metabolic process (GO:0006693)3.35478923
67phosphatidylserine acyl-chain remodeling (GO:0036150)3.35168407
68phospholipid efflux (GO:0033700)3.34589835
69fatty-acyl-CoA metabolic process (GO:0035337)3.33561476
70unsaturated fatty acid biosynthetic process (GO:0006636)3.31703652
71negative regulation of interleukin-2 production (GO:0032703)3.25901060
72macromolecular complex disassembly (GO:0032984)3.23145627
73ribosomal large subunit biogenesis (GO:0042273)3.21593934
74negative regulation of lipase activity (GO:0060192)3.19127396
75negative regulation of kidney development (GO:0090185)3.18265330
76cardiac right ventricle morphogenesis (GO:0003215)3.17047007
77negative regulation of interferon-gamma production (GO:0032689)3.16302359
78amino sugar catabolic process (GO:0046348)3.15851525
79gland morphogenesis (GO:0022612)3.13918923
80protein targeting to membrane (GO:0006612)3.08986628
81phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.03488931
82phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.97863733
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97459502
84intestinal epithelial cell development (GO:0060576)2.96798193
85glutathione biosynthetic process (GO:0006750)2.95656329
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91783943
87sphingolipid biosynthetic process (GO:0030148)2.90554870
88establishment of planar polarity (GO:0001736)2.88759854
89establishment of tissue polarity (GO:0007164)2.88759854
90positive regulation of interleukin-4 production (GO:0032753)2.86474727
91regulation of glomerulus development (GO:0090192)2.84277363
92transepithelial transport (GO:0070633)2.83930169
93negative regulation of T cell mediated immunity (GO:0002710)2.82523693
94negative regulation of acute inflammatory response (GO:0002674)2.81784074
95phospholipid scrambling (GO:0017121)2.80758676
96surfactant homeostasis (GO:0043129)2.80415780
97desmosome organization (GO:0002934)14.9928726
98establishment of skin barrier (GO:0061436)12.6515686
99regulation of water loss via skin (GO:0033561)11.5149411
100keratinization (GO:0031424)10.3617704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.60115252
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.27235908
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.85865830
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.61578898
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.45456951
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34990743
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31287805
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.18450217
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.10754028
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01945121
11TP63_17297297_ChIP-ChIP_HaCaT_Human16.1078353
12SRY_22984422_ChIP-ChIP_TESTIS_Rat1.99627566
13ZNF263_19887448_ChIP-Seq_K562_Human1.95806515
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90473834
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90473834
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.87629314
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68813452
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65634062
19BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.47313040
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.45502942
21SOX2_20726797_ChIP-Seq_SW620_Human1.43277671
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42983326
23TP63_23658742_ChIP-Seq_EP156T_Human1.35685045
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35348753
25GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.33422106
26* TP63_22573176_ChIP-Seq_HFKS_Human1.29810158
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24702110
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24325406
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24325406
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24325406
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23420177
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.22978682
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22931218
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22309934
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22302890
36GATA4_25053715_ChIP-Seq_YYC3_Human1.20137000
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19793487
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.19065327
39CJUN_26792858_Chip-Seq_BT549_Human1.10267627
40KLF5_25053715_ChIP-Seq_YYC3_Human1.10191686
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.09734131
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09344409
43GATA3_24758297_ChIP-Seq_MCF-7_Human1.06619280
44* CEBPB_22108803_ChIP-Seq_LS180_Human1.06421898
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05058561
46ATF3_27146783_Chip-Seq_COLON_Human1.04862806
47YY1_22570637_ChIP-Seq_MALME-3M_Human1.04713739
48* GATA6_21074721_ChIP-Seq_CACO-2_Human1.03739891
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02543565
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00768569
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99044000
52RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98009564
53TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97490331
54VDR_22108803_ChIP-Seq_LS180_Human0.96804582
55CDX2_20551321_ChIP-Seq_CACO-2_Human0.96251630
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95396907
57RACK7_27058665_Chip-Seq_MCF-7_Human0.94892665
58RXR_22108803_ChIP-Seq_LS180_Human0.91107097
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90201901
60TP53_18474530_ChIP-ChIP_U2OS_Human0.89508517
61NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87999965
62SA1_27219007_Chip-Seq_ERYTHROID_Human0.87959303
63LXR_22158963_ChIP-Seq_LIVER_Mouse0.87651612
64GATA6_25053715_ChIP-Seq_YYC3_Human0.86188683
65CTCF_27219007_Chip-Seq_Bcells_Human0.84314679
66TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83702505
67SA1_27219007_Chip-Seq_Bcells_Human0.77577929
68AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76758939
69GATA3_21867929_ChIP-Seq_TH1_Mouse0.76549024
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75386209
71* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75236587
72BCAT_22108803_ChIP-Seq_LS180_Human0.74527266
73PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.73919768
74ERG_21242973_ChIP-ChIP_JURKAT_Human0.73629783
75* UBF1/2_26484160_Chip-Seq_HMECs_Human0.73162885
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71993111
77SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71603082
78LXR_22292898_ChIP-Seq_THP-1_Human0.71369562
79HNFA_21074721_ChIP-Seq_CACO-2_Human0.70554422
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70550852
81RBPJ_21746931_ChIP-Seq_IB4_Human0.70520809
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70092277
83CTCF_20526341_ChIP-Seq_ESCs_Human0.69998654
84CSB_26484114_Chip-Seq_FIBROBLAST_Human0.69722930
85GATA1_22025678_ChIP-Seq_K562_Human0.69299330
86TCF4_22108803_ChIP-Seq_LS180_Human0.69206990
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.68719511
88NANOG_18692474_ChIP-Seq_MESCs_Mouse0.67248340
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66338542
90NANOG_20526341_ChIP-Seq_ESCs_Human0.66103831
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65811936
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65269144
93BCOR_27268052_Chip-Seq_Bcells_Human0.64076756
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.63198811
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.63198811
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.62440832
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.62236780
98PHF8_20622853_ChIP-Seq_HELA_Human0.62094335
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.62083257
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60943351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.33592075
2MP0003941_abnormal_skin_development6.65889504
3MP0010234_abnormal_vibrissa_follicle5.38851210
4MP0005501_abnormal_skin_physiology5.11970941
5MP0005275_abnormal_skin_tensile4.77421892
6MP0004381_abnormal_hair_follicle4.32449614
7MP0001216_abnormal_epidermal_layer3.44732060
8MP0005451_abnormal_body_composition3.40811552
9MP0002060_abnormal_skin_morphology3.37879094
10MP0003453_abnormal_keratinocyte_physiol3.16408406
11MP0010771_integument_phenotype3.10468563
12MP0002254_reproductive_system_inflammat3.00622905
13MP0002098_abnormal_vibrissa_morphology2.90764568
14MP0000566_synostosis2.89154780
15MP0010678_abnormal_skin_adnexa2.77782671
16MP0000383_abnormal_hair_follicle2.76930563
17MP0000647_abnormal_sebaceous_gland2.57523843
18MP0004947_skin_inflammation2.46109406
19MP0000579_abnormal_nail_morphology2.35236683
20MP0000377_abnormal_hair_follicle2.15908182
21MP0000467_abnormal_esophagus_morphology2.10071227
22MP0002009_preneoplasia2.03654630
23MP0009379_abnormal_foot_pigmentation1.93879737
24MP0000427_abnormal_hair_cycle1.78781018
25MP0009931_abnormal_skin_appearance1.74237945
26MP0001191_abnormal_skin_condition1.72902347
27MP0003566_abnormal_cell_adhesion1.69121388
28MP0003136_yellow_coat_color1.64264263
29MP0004185_abnormal_adipocyte_glucose1.63516686
30MP0001346_abnormal_lacrimal_gland1.55074377
31MP0000762_abnormal_tongue_morphology1.51074261
32MP0003011_delayed_dark_adaptation1.42843343
33MP0003191_abnormal_cellular_cholesterol1.42661238
34MP0000367_abnormal_coat/_hair1.36506892
35MP0001243_abnormal_dermal_layer1.33870500
36MP0003705_abnormal_hypodermis_morpholog1.30881220
37MP0010352_gastrointestinal_tract_polyps1.21656770
38MP0008004_abnormal_stomach_pH1.13676441
39MP0004782_abnormal_surfactant_physiolog1.10601075
40MP0001340_abnormal_eyelid_morphology1.06922795
41MP0001851_eye_inflammation1.04304805
42MP0004019_abnormal_vitamin_homeostasis1.03411668
43MP0001984_abnormal_olfaction0.81266795
44MP0002877_abnormal_melanocyte_morpholog0.80610167
45MP0005075_abnormal_melanosome_morpholog0.79498107
46MP0000465_gastrointestinal_hemorrhage0.78492625
47MP0005085_abnormal_gallbladder_physiolo0.73282462
48MP0005023_abnormal_wound_healing0.72095455
49MP0000627_abnormal_mammary_gland0.71959787
50MP0002006_tumorigenesis0.71195316
51MP0002277_abnormal_respiratory_mucosa0.69308588
52MP0003315_abnormal_perineum_morphology0.68207472
53MP0005076_abnormal_cell_differentiation0.65965125
54MP0001666_abnormal_nutrient_absorption0.65303929
55MP0003950_abnormal_plasma_membrane0.57304506
56MP0002166_altered_tumor_susceptibility0.56667011
57MP0002177_abnormal_outer_ear0.56642415
58MP0003718_maternal_effect0.56584028
59MP0009053_abnormal_anal_canal0.54874499
60MP0010030_abnormal_orbit_morphology0.54442309
61MP0003195_calcinosis0.53865333
62MP0003638_abnormal_response/metabolism_0.51551478
63MP0000516_abnormal_urinary_system0.50273727
64MP0005367_renal/urinary_system_phenotyp0.50273727
65MP0004264_abnormal_extraembryonic_tissu0.50090989
66MP0003436_decreased_susceptibility_to0.48797199
67MP0001784_abnormal_fluid_regulation0.48501231
68MP0002249_abnormal_larynx_morphology0.47449582
69MP0002132_abnormal_respiratory_system0.47224552
70MP0005508_abnormal_skeleton_morphology0.46834625
71MP0005666_abnormal_adipose_tissue0.46043351
72MP0008875_abnormal_xenobiotic_pharmacok0.44944723
73MP0005360_urolithiasis0.44343127
74MP0002234_abnormal_pharynx_morphology0.42484272
75MP0003938_abnormal_ear_development0.42436460
76MP0000470_abnormal_stomach_morphology0.42192923
77MP0002090_abnormal_vision0.42001709
78MP0002111_abnormal_tail_morphology0.40191961
79MP0009384_cardiac_valve_regurgitation0.39713858
80MP0003763_abnormal_thymus_physiology0.39342470
81MP0005647_abnormal_sex_gland0.37585983
82MP0005248_abnormal_Harderian_gland0.37381242
83MP0003755_abnormal_palate_morphology0.36532209
84MP0002095_abnormal_skin_pigmentation0.35194490
85MP0000372_irregular_coat_pigmentation0.33935335
86MP0005083_abnormal_biliary_tract0.33251091
87MP0002148_abnormal_hypersensitivity_rea0.30758309
88MP0000613_abnormal_salivary_gland0.28899543
89MP0000537_abnormal_urethra_morphology0.28775616
90MP0002282_abnormal_trachea_morphology0.28759822
91MP0005187_abnormal_penis_morphology0.25497561
92MP0005365_abnormal_bile_salt0.24931764
93MP0004197_abnormal_fetal_growth/weight/0.24157311
94MP0008961_abnormal_basal_metabolism0.23265507
95MP0000432_abnormal_head_morphology0.23069554
96MP0003936_abnormal_reproductive_system0.22239546
97MP0000538_abnormal_urinary_bladder0.21382174
98MP0005375_adipose_tissue_phenotype0.20822574
99MP0002233_abnormal_nose_morphology0.19346845
100MP0005165_increased_susceptibility_to0.19144978

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)9.00517788
2Congenital ichthyosiform erythroderma (HP:0007431)8.66656612
3Hypotrichosis (HP:0001006)7.30801438
4Lip pit (HP:0100267)6.60486391
5Parakeratosis (HP:0001036)6.29274430
6Woolly hair (HP:0002224)6.04874498
7Erythema (HP:0010783)5.70567178
8Right ventricular cardiomyopathy (HP:0011663)5.56514601
9Erythroderma (HP:0001019)5.18486234
10Increased IgE level (HP:0003212)5.18012680
11Plantar hyperkeratosis (HP:0007556)5.10204787
12Palmoplantar hyperkeratosis (HP:0000972)4.88783396
13Ectropion (HP:0000656)4.70730789
14Abnormality of secondary sexual hair (HP:0009888)4.68113057
15Abnormality of the axillary hair (HP:0100134)4.68113057
16Gangrene (HP:0100758)4.64414123
17Abnormality of nail color (HP:0100643)4.60031303
18Palmar hyperkeratosis (HP:0010765)4.60013381
19Corneal erosion (HP:0200020)4.41144502
20Hypohidrosis (HP:0000966)4.28470162
21Fragile nails (HP:0001808)4.26144898
22Onycholysis (HP:0001806)4.02084320
23Popliteal pterygium (HP:0009756)3.87342391
24Distal lower limb muscle weakness (HP:0009053)3.65954786
25Abnormality of the salivary glands (HP:0010286)3.63596654
26Concave nail (HP:0001598)3.62740062
27Pruritus (HP:0000989)3.61846743
28Hyporeflexia of lower limbs (HP:0002600)3.61064138
29Sparse eyelashes (HP:0000653)3.48984378
30Abnormality of cells of the erythroid lineage (HP:0012130)3.47502537
31Abnormal blistering of the skin (HP:0008066)3.47175290
32Sparse scalp hair (HP:0002209)3.41339761
33Conjunctival hamartoma (HP:0100780)3.22191389
34Areflexia of lower limbs (HP:0002522)3.20870747
35Curly hair (HP:0002212)3.19693291
36Reticulocytopenia (HP:0001896)3.14302285
37Palmoplantar keratoderma (HP:0000982)3.11370111
38Nail dystrophy (HP:0008404)2.99265538
39Ventricular tachycardia (HP:0004756)2.97950798
40Pili torti (HP:0003777)2.95411621
41Abnormal hemoglobin (HP:0011902)2.90645109
42Abnormal number of erythroid precursors (HP:0012131)2.88843783
43Natal tooth (HP:0000695)2.88829467
44Acanthosis nigricans (HP:0000956)2.88058829
45Hypoplastic labia majora (HP:0000059)2.79803393
46Brittle hair (HP:0002299)2.78716144
47Dry skin (HP:0000958)2.71463428
48Dehydration (HP:0001944)2.64126941
49Advanced eruption of teeth (HP:0006288)2.63841238
50Lack of skin elasticity (HP:0100679)2.59282578
51Macrocytic anemia (HP:0001972)2.58095397
52Milia (HP:0001056)2.56186604
53Congenital, generalized hypertrichosis (HP:0004540)2.55017314
54Abnormality of the labia majora (HP:0012881)2.53235354
55Anhidrosis (HP:0000970)2.46070239
56Paralysis (HP:0003470)2.39343148
57Abnormal hair laboratory examination (HP:0003328)2.31288067
58Oligodontia (HP:0000677)2.30522814
59Severe Myopia (HP:0011003)2.23414976
60Conical tooth (HP:0000698)2.17183060
61Septate vagina (HP:0001153)2.16981540
62Stenosis of the external auditory canal (HP:0000402)2.15329986
63Thick nail (HP:0001805)2.10321541
64Pallor (HP:0000980)2.07323676
65Premature ovarian failure (HP:0008209)2.02535254
66Pterygium (HP:0001059)2.00199147
67Intrahepatic cholestasis (HP:0001406)1.94581108
68Type I diabetes mellitus (HP:0100651)1.93624394
69Abnormality of the gastric mucosa (HP:0004295)1.93339509
70Malignant hyperthermia (HP:0002047)1.92615661
71Ulnar claw (HP:0001178)1.90553432
72Achilles tendon contracture (HP:0001771)1.89649869
73Abnormality of the Achilles tendon (HP:0005109)1.86617717
74Skin pits (HP:0100276)1.83617046
75Pustule (HP:0200039)1.79869041
76Down-sloping shoulders (HP:0200021)1.75026773
77Bifid scrotum (HP:0000048)1.74566304
78Ridged nail (HP:0001807)1.73933169
79Abnormality of the distal phalanges of the toes (HP:0010182)1.72646138
80Hypodontia (HP:0000668)1.71678773
81Labial hypoplasia (HP:0000066)1.71666650
82Alopecia of scalp (HP:0002293)1.70558416
83Absent eyebrow (HP:0002223)1.70284766
84Blepharitis (HP:0000498)1.69208494
85Xanthomatosis (HP:0000991)1.67039625
86Hypoplasia of the uterus (HP:0000013)1.66800471
87Sepsis (HP:0100806)1.65355196
88Hamartoma of the eye (HP:0010568)1.63496562
89Aplasia/hypoplasia of the uterus (HP:0008684)1.61303152
90Hypoplastic female external genitalia (HP:0012815)1.60308204
91Fasciculations (HP:0002380)1.60106332
92Ventricular fibrillation (HP:0001663)1.59824387
93Trismus (HP:0000211)1.58513444
94Hypergammaglobulinemia (HP:0010702)1.55447586
95Hypoparathyroidism (HP:0000829)1.51672014
96Partial duplication of thumb phalanx (HP:0009944)1.51056629
97Aplasia involving bones of the extremities (HP:0009825)1.51031525
98Aplasia involving bones of the upper limbs (HP:0009823)1.51031525
99Aplasia of the phalanges of the hand (HP:0009802)1.51031525
100Abnormality of small intestinal villus morphology (HP:0011472)1.50098337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK36.07987564
2MST1R5.16735103
3MST44.66580869
4MAP3K34.23822014
5RPS6KB23.34883808
6FER2.82660759
7PIM22.40714351
8MAP3K22.32958111
9EPHA21.91987197
10MAP3K111.85205856
11STK101.78087006
12ERN11.77994236
13MET1.73083548
14TRPM71.72243976
15EPHB21.61950870
16LRRK21.60125806
17LATS11.59661986
18STK241.54680626
19NME21.48348362
20MAPKAPK51.47982305
21BLK1.44418827
22TESK11.43990643
23PIK3CG1.43332160
24GRK11.39531778
25DYRK1B1.35855877
26BCR1.33668637
27FGFR21.27285157
28GRK71.26193160
29MAP3K141.24881585
30FGFR41.24390586
31MAP2K61.23469966
32NTRK21.17966634
33ERBB31.10133417
34CDK61.07765116
35RIPK11.05544050
36IRAK30.99592272
37TGFBR20.98982652
38EIF2AK20.97879443
39TAOK10.91671354
40GRK50.87911093
41MAP3K60.82835341
42MAPK150.80047624
43PTK60.79678913
44CDK30.79617932
45MAP3K10.78222538
46MAPKAPK20.76837585
47TYRO30.74855095
48EEF2K0.74825463
49MAP3K50.73359703
50LATS20.71660549
51MAP3K120.70722899
52MAP2K30.69800512
53IKBKB0.68716764
54ADRBK10.66313939
55PRKCI0.64392431
56ITK0.64318235
57MAP2K40.61385512
58EPHA30.59729230
59LIMK10.57858173
60TYK20.57264818
61FGFR30.56863647
62EPHA40.53954042
63AURKA0.52779975
64TTK0.51024521
65STK38L0.50696629
66BCKDK0.49967534
67TAOK20.48885653
68BMPR1B0.48775092
69MAP3K70.46098415
70MOS0.45814058
71BMPR20.44864422
72STK110.44105927
73FGFR10.43552422
74PBK0.42961438
75TLK10.42092461
76MAP2K20.41628525
77RIPK40.41479197
78TNK20.41174997
79SIK10.41118697
80CDK190.39099431
81CSNK1D0.39079605
82FRK0.36384075
83PRKD10.35521347
84SRPK10.35028911
85ILK0.33357293
86RPS6KA40.32792358
87DYRK30.32460395
88BRAF0.32279153
89MAPK40.31279941
90ERBB40.30964881
91GSK3A0.28538915
92AURKB0.27564631
93PRKCE0.27232339
94OBSCN0.26684568
95TTN0.26643534
96ABL10.26015408
97CSNK1E0.23440824
98JAK20.23268546
99DYRK20.22588942
100RPS6KA10.22197020

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.21894904
2Ribosome_Homo sapiens_hsa030105.29300476
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.82920802
4Sphingolipid metabolism_Homo sapiens_hsa006003.73166689
5Arachidonic acid metabolism_Homo sapiens_hsa005903.57791921
6Linoleic acid metabolism_Homo sapiens_hsa005913.35077445
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.19791527
8Fatty acid elongation_Homo sapiens_hsa000622.90458096
9Histidine metabolism_Homo sapiens_hsa003402.51605133
10Phenylalanine metabolism_Homo sapiens_hsa003602.51107240
11Retinol metabolism_Homo sapiens_hsa008302.48402050
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16564880
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15616755
14Chemical carcinogenesis_Homo sapiens_hsa052041.91741715
15Ether lipid metabolism_Homo sapiens_hsa005651.83956554
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.70037368
17Tyrosine metabolism_Homo sapiens_hsa003501.61661489
18Staphylococcus aureus infection_Homo sapiens_hsa051501.47195746
19ABC transporters_Homo sapiens_hsa020101.31459433
20Glutathione metabolism_Homo sapiens_hsa004801.28219754
21p53 signaling pathway_Homo sapiens_hsa041151.25264567
22beta-Alanine metabolism_Homo sapiens_hsa004101.21522439
23Basal cell carcinoma_Homo sapiens_hsa052171.15740340
24Folate biosynthesis_Homo sapiens_hsa007901.15468119
25Fat digestion and absorption_Homo sapiens_hsa049751.13761541
26Steroid biosynthesis_Homo sapiens_hsa001001.12893816
27Bladder cancer_Homo sapiens_hsa052190.99232628
28Caffeine metabolism_Homo sapiens_hsa002320.98614597
29Complement and coagulation cascades_Homo sapiens_hsa046100.97607297
30Steroid hormone biosynthesis_Homo sapiens_hsa001400.96709319
31Tight junction_Homo sapiens_hsa045300.92710646
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87180817
33VEGF signaling pathway_Homo sapiens_hsa043700.85377384
34Sphingolipid signaling pathway_Homo sapiens_hsa040710.84872482
35Fatty acid degradation_Homo sapiens_hsa000710.83506958
36Adherens junction_Homo sapiens_hsa045200.77896254
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77646694
38Serotonergic synapse_Homo sapiens_hsa047260.76728734
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71783469
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70669307
41Fatty acid biosynthesis_Homo sapiens_hsa000610.70577352
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69965767
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68767785
44Hippo signaling pathway_Homo sapiens_hsa043900.67448972
45Axon guidance_Homo sapiens_hsa043600.63822850
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.63583759
47PPAR signaling pathway_Homo sapiens_hsa033200.62966438
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62442267
49Tryptophan metabolism_Homo sapiens_hsa003800.62113899
50Peroxisome_Homo sapiens_hsa041460.61990314
51Phototransduction_Homo sapiens_hsa047440.61239122
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60574696
53Hedgehog signaling pathway_Homo sapiens_hsa043400.59898177
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57476650
55Arginine biosynthesis_Homo sapiens_hsa002200.55215644
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53658693
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53111888
58Ovarian steroidogenesis_Homo sapiens_hsa049130.52768131
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48648590
60GnRH signaling pathway_Homo sapiens_hsa049120.45574778
61Mineral absorption_Homo sapiens_hsa049780.44612973
62Pancreatic secretion_Homo sapiens_hsa049720.44384944
63Renin secretion_Homo sapiens_hsa049240.43506983
64Fatty acid metabolism_Homo sapiens_hsa012120.43213553
65Hepatitis C_Homo sapiens_hsa051600.43171404
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41217944
67Oxidative phosphorylation_Homo sapiens_hsa001900.40816108
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39240066
69ECM-receptor interaction_Homo sapiens_hsa045120.38692485
70Vitamin digestion and absorption_Homo sapiens_hsa049770.38532710
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38369803
72Proteoglycans in cancer_Homo sapiens_hsa052050.38139942
73Ras signaling pathway_Homo sapiens_hsa040140.37984238
74Melanogenesis_Homo sapiens_hsa049160.37909642
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36625461
76MicroRNAs in cancer_Homo sapiens_hsa052060.36121901
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34228598
78Sulfur metabolism_Homo sapiens_hsa009200.32802562
79Collecting duct acid secretion_Homo sapiens_hsa049660.32754022
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30636823
81TGF-beta signaling pathway_Homo sapiens_hsa043500.29020602
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28231739
83Metabolic pathways_Homo sapiens_hsa011000.27648905
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26076880
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25777888
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.23169994
87Thyroid cancer_Homo sapiens_hsa052160.22170237
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.20851829
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.19218486
90Long-term depression_Homo sapiens_hsa047300.19024271
91Platelet activation_Homo sapiens_hsa046110.17381578
92Wnt signaling pathway_Homo sapiens_hsa043100.17062959
93Amoebiasis_Homo sapiens_hsa051460.16893637
94Pertussis_Homo sapiens_hsa051330.15893725
95Glycerolipid metabolism_Homo sapiens_hsa005610.15459988
96Protein digestion and absorption_Homo sapiens_hsa049740.13829214
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.13020662
98Proteasome_Homo sapiens_hsa030500.12435738
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12339898
100ErbB signaling pathway_Homo sapiens_hsa040120.10829369

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