FAM25G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.97244071
2keratinocyte proliferation (GO:0043616)8.34646248
3keratinocyte development (GO:0003334)8.17914844
4keratinocyte differentiation (GO:0030216)7.39778694
5gap junction assembly (GO:0016264)7.15851476
6multicellular organismal water homeostasis (GO:0050891)6.90264454
7epidermal cell differentiation (GO:0009913)6.43458750
8positive regulation of cellular amide metabolic process (GO:0034250)6.31045054
9atrial cardiac muscle cell action potential (GO:0086014)6.25155316
10regulation of transforming growth factor beta1 production (GO:0032908)6.15962461
11positive regulation of glomerulus development (GO:0090193)6.02733698
12water homeostasis (GO:0030104)5.79912157
13regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.68044623
14positive regulation of interleukin-8 secretion (GO:2000484)5.66386564
15endothelium development (GO:0003158)5.55372604
16molting cycle (GO:0042303)5.49215576
17hair cycle (GO:0042633)5.49215576
18regulation of glomerular filtration (GO:0003093)5.26770312
19regulation of cell proliferation involved in kidney development (GO:1901722)5.18369684
20peptide cross-linking (GO:0018149)5.11404430
21skeletal muscle tissue regeneration (GO:0043403)5.00835065
22epithelial cell maturation (GO:0002070)4.99825312
23purine ribonucleotide transport (GO:0015868)4.89931961
24epidermis development (GO:0008544)4.88189803
25adenine nucleotide transport (GO:0051503)4.75456758
26positive regulation of p38MAPK cascade (GO:1900745)4.60178552
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.56477845
28negative regulation of heart growth (GO:0061117)4.43864176
29negative regulation of cardiac muscle tissue growth (GO:0055022)4.43864176
30regulation of glomerulus development (GO:0090192)4.39299666
31polarized epithelial cell differentiation (GO:0030859)4.37961631
32positive regulation of humoral immune response (GO:0002922)4.19846003
33regulation of interleukin-8 secretion (GO:2000482)4.12197305
34regulation of tight junction assembly (GO:2000810)4.10898248
35cellular response to arsenic-containing substance (GO:0071243)4.04469078
36defense response to Gram-negative bacterium (GO:0050829)4.01888106
37regulation of keratinocyte differentiation (GO:0045616)3.99660803
38imidazole-containing compound metabolic process (GO:0052803)3.99467378
39intestinal epithelial cell development (GO:0060576)3.97406549
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.92342619
41renal system process involved in regulation of blood volume (GO:0001977)3.85167642
42positive regulation of T-helper 1 type immune response (GO:0002827)3.83203108
43chronic inflammatory response (GO:0002544)3.74549742
44purine nucleotide transport (GO:0015865)3.70919740
45defense response to fungus (GO:0050832)3.68121153
46lateral sprouting from an epithelium (GO:0060601)3.68076730
47regulation of oxidative phosphorylation (GO:0002082)3.66851826
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.66818161
49antimicrobial humoral response (GO:0019730)3.55882061
50regulation of axon regeneration (GO:0048679)3.55090190
51regulation of neuron projection regeneration (GO:0070570)3.55090190
52regulation of epidermis development (GO:0045682)3.43224921
53hair cell differentiation (GO:0035315)3.43051988
54magnesium ion transport (GO:0015693)3.42325553
55positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.41832477
56regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.41832477
57negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.41308378
58regulation of p38MAPK cascade (GO:1900744)3.37595077
59chemical homeostasis within a tissue (GO:0048875)3.34884675
60fatty acid elongation (GO:0030497)3.26108126
61positive regulation of meiotic cell cycle (GO:0051446)3.22401313
62intermediate filament cytoskeleton organization (GO:0045104)3.21252718
63intermediate filament-based process (GO:0045103)3.17710738
64lipoxygenase pathway (GO:0019372)3.14810372
65regulation of keratinocyte proliferation (GO:0010837)3.14601290
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.12151251
67natural killer cell mediated immunity (GO:0002228)3.11370250
68natural killer cell mediated cytotoxicity (GO:0042267)3.11370250
69regulation of epidermal cell differentiation (GO:0045604)3.11150177
70positive regulation of transforming growth factor beta production (GO:0071636)3.10659705
71adult heart development (GO:0007512)3.08684724
72one-carbon compound transport (GO:0019755)3.05159708
73nucleoside transport (GO:0015858)3.02570460
74negative regulation of keratinocyte proliferation (GO:0010839)3.02552729
75phosphatidylcholine acyl-chain remodeling (GO:0036151)3.00417943
76surfactant homeostasis (GO:0043129)2.94167560
77cardiac muscle cell action potential involved in contraction (GO:0086002)2.93330480
78regulation of T-helper 1 type immune response (GO:0002825)2.92565177
79multicellular organism reproduction (GO:0032504)2.91429693
80intermediate filament organization (GO:0045109)2.90582852
81parturition (GO:0007567)2.90440447
82negative regulation of cardiac muscle tissue development (GO:0055026)2.90374757
83long-chain fatty acid biosynthetic process (GO:0042759)2.87072034
84hair follicle morphogenesis (GO:0031069)2.86532887
85early endosome to late endosome transport (GO:0045022)2.86441443
86phosphatidylserine acyl-chain remodeling (GO:0036150)2.86289129
87cardiac muscle cell action potential (GO:0086001)2.83617718
88renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.79801362
89G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79281313
90ribosomal small subunit biogenesis (GO:0042274)2.77408075
91reflex (GO:0060004)2.77075085
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75360625
93positive regulation of epidermis development (GO:0045684)2.74120890
94phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.73954501
95pyrimidine-containing compound transmembrane transport (GO:0072531)2.71671409
96regulation of membrane repolarization (GO:0060306)2.71488983
97antibacterial humoral response (GO:0019731)2.71478714
98keratinization (GO:0031424)18.6598404
99establishment of skin barrier (GO:0061436)13.2997419
100regulation of water loss via skin (GO:0033561)11.2282730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.16954839
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.64669868
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.60950906
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.32727200
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.81253188
6P63_26484246_Chip-Seq_KERATINOCYTES_Human3.20632253
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69544153
8IGF1R_20145208_ChIP-Seq_DFB_Human2.65904581
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.65424873
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62692234
11TP63_23658742_ChIP-Seq_EP156T_Human2.23238075
12FUS_26573619_Chip-Seq_HEK293_Human2.15949101
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15600772
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99537395
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99537395
16EGR1_19032775_ChIP-ChIP_M12_Human1.91653036
17RXR_22108803_ChIP-Seq_LS180_Human1.76218355
18TP53_18474530_ChIP-ChIP_U2OS_Human1.74431871
19FOXM1_26456572_ChIP-Seq_MCF-7_Human1.68117289
20AHR_22903824_ChIP-Seq_MCF-7_Human1.66512161
21SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64225121
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60457390
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60457390
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.54327300
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48566495
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.46831142
27ER_23166858_ChIP-Seq_MCF-7_Human1.46762278
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44666668
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44666668
30CDX2_22108803_ChIP-Seq_LS180_Human1.44581712
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43550758
32AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43382492
33CBP_20019798_ChIP-Seq_JUKART_Human1.39758419
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39758419
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.36468283
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35768155
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34848980
38CJUN_26792858_Chip-Seq_BT549_Human1.34432818
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34185409
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30875591
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29468087
42AR_21909140_ChIP-Seq_LNCAP_Human1.27897568
43P300_19829295_ChIP-Seq_ESCs_Human1.27440902
44VDR_22108803_ChIP-Seq_LS180_Human1.27083343
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25571493
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25478660
47EWS_26573619_Chip-Seq_HEK293_Human1.24416585
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.22278461
49AR_25329375_ChIP-Seq_VCAP_Human1.21276348
50ERG_20517297_ChIP-Seq_VCAP_Human1.18542853
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18226392
52ELF5_23300383_ChIP-Seq_T47D_Human1.17016240
53NANOG_19829295_ChIP-Seq_ESCs_Human1.16614223
54SOX2_19829295_ChIP-Seq_ESCs_Human1.16614223
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16587435
56ELK1_19687146_ChIP-ChIP_HELA_Human1.12674485
57GATA4_25053715_ChIP-Seq_YYC3_Human1.12463765
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10756948
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08574470
60TAF15_26573619_Chip-Seq_HEK293_Human1.07272851
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.07153035
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03925036
63TCF4_22108803_ChIP-Seq_LS180_Human1.00530594
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00395531
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.00133586
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00086087
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98329283
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97019089
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.96610100
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94750313
71SOX2_20726797_ChIP-Seq_SW620_Human0.94415784
72P53_21459846_ChIP-Seq_SAOS-2_Human0.93857468
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93819539
74GABP_17652178_ChIP-ChIP_JURKAT_Human0.93221499
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.93045023
76BCAT_22108803_ChIP-Seq_LS180_Human0.91959834
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89760052
78NCOR_22424771_ChIP-Seq_293T_Human0.89330037
79* TP63_22573176_ChIP-Seq_HFKS_Human0.88452964
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88011607
81TP53_16413492_ChIP-PET_HCT116_Human0.87450339
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87296591
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.87021642
84RBPJ_21746931_ChIP-Seq_IB4_Human0.86859299
85CEBPB_22108803_ChIP-Seq_LS180_Human0.86548681
86NANOG_20526341_ChIP-Seq_ESCs_Human0.85766231
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.85475460
88SMAD4_21799915_ChIP-Seq_A2780_Human0.85473346
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84941804
90TBL1_22424771_ChIP-Seq_293T_Human0.84066964
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83553982
92AR_21572438_ChIP-Seq_LNCaP_Human0.82905075
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82794100
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81583080
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79386945
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.78759710
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78347094
98MYC_18940864_ChIP-ChIP_HL60_Human0.77404009
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76586497
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75292864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.27589675
2MP0010234_abnormal_vibrissa_follicle7.16180794
3MP0005501_abnormal_skin_physiology5.05625779
4MP0005275_abnormal_skin_tensile5.03244925
5MP0003941_abnormal_skin_development4.19388189
6MP0000579_abnormal_nail_morphology3.82882632
7MP0009379_abnormal_foot_pigmentation3.62243628
8MP0010678_abnormal_skin_adnexa3.04478659
9MP0009384_cardiac_valve_regurgitation2.80042999
10MP0008004_abnormal_stomach_pH2.74914913
11MP0001216_abnormal_epidermal_layer2.68088986
12MP0003453_abnormal_keratinocyte_physiol2.57903662
13MP0004381_abnormal_hair_follicle2.52634108
14MP0010771_integument_phenotype2.52162533
15MP0001188_hyperpigmentation2.51292493
16MP0002098_abnormal_vibrissa_morphology2.18553072
17MP0003191_abnormal_cellular_cholesterol1.96996023
18MP0000383_abnormal_hair_follicle1.94806955
19MP0004782_abnormal_surfactant_physiolog1.79071069
20MP0001853_heart_inflammation1.76452481
21MP0003950_abnormal_plasma_membrane1.74626840
22MP0003806_abnormal_nucleotide_metabolis1.73287761
23MP0004947_skin_inflammation1.68797053
24MP0002060_abnormal_skin_morphology1.68336028
25MP0000377_abnormal_hair_follicle1.64226992
26MP0000566_synostosis1.61968630
27MP0003718_maternal_effect1.55465528
28MP0000427_abnormal_hair_cycle1.54159256
29MP0003315_abnormal_perineum_morphology1.46149843
30MP0001984_abnormal_olfaction1.43263108
31MP0001542_abnormal_bone_strength1.37789353
32MP0005410_abnormal_fertilization1.34248596
33MP0001191_abnormal_skin_condition1.32856866
34MP0000367_abnormal_coat/_hair1.30038849
35MP0005503_abnormal_tendon_morphology1.26605537
36MP0002095_abnormal_skin_pigmentation1.22215629
37MP0003279_aneurysm1.14662604
38MP0000750_abnormal_muscle_regeneration1.06966825
39MP0009931_abnormal_skin_appearance1.05212841
40MP0000647_abnormal_sebaceous_gland1.03521422
41MP0003011_delayed_dark_adaptation1.03245495
42MP0005174_abnormal_tail_pigmentation1.03241691
43MP0008995_early_reproductive_senescence0.92429229
44MP0000762_abnormal_tongue_morphology0.91969661
45MP0000015_abnormal_ear_pigmentation0.87807246
46MP0002009_preneoplasia0.83804551
47MP0002160_abnormal_reproductive_system0.81084506
48MP0001881_abnormal_mammary_gland0.80855481
49MP0000465_gastrointestinal_hemorrhage0.80190379
50MP0004264_abnormal_extraembryonic_tissu0.78982737
51MP0004215_abnormal_myocardial_fiber0.73626588
52MP0000467_abnormal_esophagus_morphology0.73117907
53MP0008057_abnormal_DNA_replication0.71795864
54MP0001851_eye_inflammation0.69063331
55MP0006072_abnormal_retinal_apoptosis0.65467831
56MP0001784_abnormal_fluid_regulation0.65147232
57MP0000627_abnormal_mammary_gland0.64042444
58MP0002277_abnormal_respiratory_mucosa0.63068439
59MP0002638_abnormal_pupillary_reflex0.62416644
60MP0002090_abnormal_vision0.61937519
61MP0005197_abnormal_uvea_morphology0.61198832
62MP0001440_abnormal_grooming_behavior0.60958484
63MP0002877_abnormal_melanocyte_morpholog0.59815336
64MP0001756_abnormal_urination0.58543517
65MP0002233_abnormal_nose_morphology0.58405675
66MP0001340_abnormal_eyelid_morphology0.55754805
67MP0000049_abnormal_middle_ear0.55268175
68MP0000372_irregular_coat_pigmentation0.54099366
69MP0000230_abnormal_systemic_arterial0.52118130
70MP0004272_abnormal_basement_membrane0.52041641
71MP0009697_abnormal_copulation0.51912360
72MP0002876_abnormal_thyroid_physiology0.50269978
73MP0004510_myositis0.49070618
74MP0000428_abnormal_craniofacial_morphol0.49041831
75MP0003936_abnormal_reproductive_system0.48363581
76MP0010386_abnormal_urinary_bladder0.46426724
77MP0005171_absent_coat_pigmentation0.46373551
78MP0010030_abnormal_orbit_morphology0.45575962
79MP0004885_abnormal_endolymph0.44639612
80MP0008789_abnormal_olfactory_epithelium0.43860821
81MP0005508_abnormal_skeleton_morphology0.42269646
82MP0003638_abnormal_response/metabolism_0.41085546
83MP0004484_altered_response_of0.39951049
84MP0003698_abnormal_male_reproductive0.38787524
85MP0008961_abnormal_basal_metabolism0.37620746
86MP0009672_abnormal_birth_weight0.36683664
87MP0005389_reproductive_system_phenotype0.36422380
88MP0003755_abnormal_palate_morphology0.36378802
89MP0005193_abnormal_anterior_eye0.36146959
90MP0002177_abnormal_outer_ear0.35940176
91MP0005647_abnormal_sex_gland0.35453975
92MP0003137_abnormal_impulse_conducting0.34654851
93MP0002998_abnormal_bone_remodeling0.33419544
94MP0003786_premature_aging0.31804383
95MP0000462_abnormal_digestive_system0.31727342
96MP0005395_other_phenotype0.30932203
97MP0001664_abnormal_digestion0.30901005
98MP0001929_abnormal_gametogenesis0.29896370
99MP0003221_abnormal_cardiomyocyte_apopto0.29704866
100MP0009333_abnormal_splenocyte_physiolog0.29418954

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.90409062
2Increased IgE level (HP:0003212)6.84273407
3Erythroderma (HP:0001019)6.49847641
4Congenital ichthyosiform erythroderma (HP:0007431)6.36967753
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.31372008
6Fragile nails (HP:0001808)6.17179920
7Palmoplantar hyperkeratosis (HP:0000972)5.81010596
8Palmar hyperkeratosis (HP:0010765)5.67012401
9Aplasia involving bones of the extremities (HP:0009825)5.30513420
10Aplasia involving bones of the upper limbs (HP:0009823)5.30513420
11Aplasia of the phalanges of the hand (HP:0009802)5.30513420
12Parakeratosis (HP:0001036)5.29365538
13Hypotrichosis (HP:0001006)5.22357810
14Dry hair (HP:0011359)5.09244171
15Abnormality of the axillary hair (HP:0100134)5.06258331
16Abnormality of secondary sexual hair (HP:0009888)5.06258331
17Plantar hyperkeratosis (HP:0007556)4.84034342
18Short middle phalanx of the 5th finger (HP:0004220)4.81462283
19Selective tooth agenesis (HP:0001592)4.66862197
20Erythema (HP:0010783)4.61596317
21Long nose (HP:0003189)4.27454633
22Thick nail (HP:0001805)4.27371729
23Abnormality of the columella (HP:0009929)4.13327423
24Tetraparesis (HP:0002273)3.89553834
25Abnormality of the dental root (HP:0006486)3.74061062
26Taurodontia (HP:0000679)3.74061062
27Abnormality of permanent molar morphology (HP:0011071)3.74061062
28Sparse scalp hair (HP:0002209)3.71287413
29Alopecia of scalp (HP:0002293)3.63455636
30Corneal erosion (HP:0200020)3.61591076
31Onycholysis (HP:0001806)3.59450857
32Lip pit (HP:0100267)3.51658399
33Abnormality of molar morphology (HP:0011070)3.48839376
34Abnormality of molar (HP:0011077)3.48839376
35Palmoplantar keratoderma (HP:0000982)3.46460531
36Oral leukoplakia (HP:0002745)3.44970250
37Abnormality of the dental pulp (HP:0006479)3.36788984
38Broad alveolar ridges (HP:0000187)3.20576279
39Woolly hair (HP:0002224)3.10324198
40Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.02911794
41Conjunctival hamartoma (HP:0100780)2.94817111
42Nasolacrimal duct obstruction (HP:0000579)2.83440626
43Median cleft lip (HP:0000161)2.74437357
44Sensory axonal neuropathy (HP:0003390)2.69586437
45Atrioventricular block (HP:0001678)2.69269815
46Ectropion (HP:0000656)2.69180537
47Hypohidrosis (HP:0000966)2.69031466
48Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.67809293
49Slow-growing hair (HP:0002217)2.63349644
50Abnormality of hair growth rate (HP:0011363)2.63349644
51Mixed hearing impairment (HP:0000410)2.59801672
52Gangrene (HP:0100758)2.56231505
53Hypoplastic labia majora (HP:0000059)2.56030479
54Oligodontia (HP:0000677)2.52438480
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.52287416
56Right ventricular cardiomyopathy (HP:0011663)2.41337273
57Hypoplasia of dental enamel (HP:0006297)2.36980657
58Abnormality of the labia majora (HP:0012881)2.36214569
59Nail dystrophy (HP:0008404)2.34820155
60Curly hair (HP:0002212)2.33705988
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.25815584
62Pruritus (HP:0000989)2.25645418
63Abnormality of the lacrimal duct (HP:0011481)2.23763093
64Non-midline cleft lip (HP:0100335)2.20001519
65Absent eyelashes (HP:0000561)2.19595411
66Abnormality of the alveolar ridges (HP:0006477)2.19403331
67Hypoplasia of the uterus (HP:0000013)2.19085393
68Hyperhidrosis (HP:0000975)2.18589241
69Aplasia cutis congenita (HP:0001057)2.17774353
70Hypoplastic left heart (HP:0004383)2.15132163
71Hyporeflexia of lower limbs (HP:0002600)2.14246655
72Follicular hyperkeratosis (HP:0007502)2.11588140
73Conical tooth (HP:0000698)2.11182375
74Narrow nasal bridge (HP:0000446)2.08807096
75Pustule (HP:0200039)2.05810513
76Short hallux (HP:0010109)2.04860018
77Corneal dystrophy (HP:0001131)2.01613787
78Abnormality of the nasolacrimal system (HP:0000614)2.01224242
79Sparse eyelashes (HP:0000653)1.99518011
80Furrowed tongue (HP:0000221)1.93702275
81Abnormality of the salivary glands (HP:0010286)1.93250347
82Aplasia/hypoplasia of the uterus (HP:0008684)1.92595763
83Absent hair (HP:0002298)1.91635100
84Congenital, generalized hypertrichosis (HP:0004540)1.91303805
85Abnormal sex determination (HP:0012244)1.90782824
86Sex reversal (HP:0012245)1.90782824
87Brittle hair (HP:0002299)1.89622385
88Xerostomia (HP:0000217)1.88845884
89Maternal diabetes (HP:0009800)1.87497323
90Eczematoid dermatitis (HP:0000976)1.85825147
91Abnormality of the renal collecting system (HP:0004742)1.84956787
92Premature loss of primary teeth (HP:0006323)1.83261593
93Duplicated collecting system (HP:0000081)1.83230339
94Abnormality of small intestinal villus morphology (HP:0011472)1.82151986
95Villous atrophy (HP:0011473)1.82151986
96Split foot (HP:0001839)1.81302980
97Aplasia/Hypoplasia of the hallux (HP:0008362)1.79828370
98Basal ganglia calcification (HP:0002135)1.77879785
99Abnormal blistering of the skin (HP:0008066)1.76059841
100Laryngomalacia (HP:0001601)1.74818539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK247.84124575
2EPHA25.09246387
3PINK14.23142258
4MAP3K123.55517872
5FRK3.40509637
6TGFBR12.67566501
7MYLK2.42713257
8MARK32.36877392
9STK32.27479218
10MAPK72.27346580
11TLK12.08716796
12MAPK122.00958649
13DYRK31.74638363
14ERBB31.70579700
15BMPR1B1.54726501
16ILK1.43818765
17LATS11.43232182
18PRKCE1.42797912
19CDK121.40064400
20GRK71.37081967
21STK38L1.31682774
22TGFBR21.28172257
23MST41.26295000
24ADRBK11.23730881
25BMPR21.23440285
26MOS1.18383629
27ZAK1.14634836
28BRSK21.05577024
29RPS6KA51.05007720
30TAOK31.04205953
31ABL21.02162442
32CDK31.00399263
33MAP3K20.99705234
34FGFR10.95876546
35TAF10.95095060
36KIT0.93108250
37EIF2AK30.90513993
38MAP3K30.89691035
39PIK3CG0.86735423
40PRKCG0.85617020
41IRAK20.84355704
42MKNK20.82553100
43PKN10.82374478
44STK100.81690534
45PIM20.80670283
46ADRBK20.76680769
47FGFR20.69588147
48WNK10.68236818
49GRK50.67782377
50IKBKB0.67466068
51MST1R0.66244156
52MAPK150.66006352
53LATS20.65784191
54CSNK1A1L0.65636375
55DMPK0.64216921
56STK160.63794397
57MAP2K70.63707954
58TRPM70.63014188
59NUAK10.58213088
60GRK10.56984761
61ARAF0.53706752
62AKT30.53646547
63DAPK30.50385599
64CSNK1G30.50121090
65RPS6KB10.49477894
66PBK0.49296196
67NLK0.48646682
68RPS6KA40.47864345
69NEK20.45713801
70EIF2AK20.44889950
71TRIM280.43149969
72IGF1R0.42955601
73RPS6KB20.42010357
74TESK10.40908866
75CSNK1G10.40854952
76PLK20.38375729
77CSNK1D0.37266427
78CSNK1G20.35342000
79ACVR1B0.34860245
80MAP3K90.34224963
81MAP3K50.33443416
82PRKG10.31490064
83IRAK10.31468141
84CSNK1E0.29697175
85CDK70.29467792
86MAPKAPK30.28481246
87ABL10.26980216
88SGK2230.26036336
89SGK4940.26036336
90VRK10.25603508
91MAPKAPK50.24974670
92MAP3K10.24804616
93FER0.24242296
94PRKCI0.23178351
95AURKA0.23092893
96MKNK10.23080084
97SGK20.22006758
98BCR0.21824485
99PDGFRB0.21664912
100IKBKE0.19612053

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.20569098
2Ribosome_Homo sapiens_hsa030104.11460986
3Linoleic acid metabolism_Homo sapiens_hsa005913.57386093
4Oxidative phosphorylation_Homo sapiens_hsa001903.32960966
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.98102548
6Sphingolipid metabolism_Homo sapiens_hsa006002.51475636
7Histidine metabolism_Homo sapiens_hsa003402.49017033
8Parkinsons disease_Homo sapiens_hsa050122.48835407
9Circadian rhythm_Homo sapiens_hsa047102.45991161
10Dorso-ventral axis formation_Homo sapiens_hsa043202.41879673
11Ether lipid metabolism_Homo sapiens_hsa005652.32383417
12Arachidonic acid metabolism_Homo sapiens_hsa005902.28868870
13Gap junction_Homo sapiens_hsa045402.17365202
14Protein export_Homo sapiens_hsa030602.09690156
15Alzheimers disease_Homo sapiens_hsa050101.87225278
16Basal transcription factors_Homo sapiens_hsa030221.78895816
17Hedgehog signaling pathway_Homo sapiens_hsa043401.77653598
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.68891837
19Huntingtons disease_Homo sapiens_hsa050161.62976682
20p53 signaling pathway_Homo sapiens_hsa041151.62871421
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56312473
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43093446
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41586277
24Chemical carcinogenesis_Homo sapiens_hsa052041.41393444
25Collecting duct acid secretion_Homo sapiens_hsa049661.41004037
26Retinol metabolism_Homo sapiens_hsa008301.26312506
27Ovarian steroidogenesis_Homo sapiens_hsa049131.21354693
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14899115
29Regulation of autophagy_Homo sapiens_hsa041401.13622007
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13484284
31Nitrogen metabolism_Homo sapiens_hsa009101.11595454
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10947915
33Systemic lupus erythematosus_Homo sapiens_hsa053221.07110916
34Fatty acid elongation_Homo sapiens_hsa000621.06650522
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.03447628
36Phagosome_Homo sapiens_hsa041451.02892010
37Vascular smooth muscle contraction_Homo sapiens_hsa042700.99974649
38Renin secretion_Homo sapiens_hsa049240.99323463
39Olfactory transduction_Homo sapiens_hsa047400.99206172
40ABC transporters_Homo sapiens_hsa020100.96682264
41Arginine biosynthesis_Homo sapiens_hsa002200.95439804
42Cardiac muscle contraction_Homo sapiens_hsa042600.93939628
43Mineral absorption_Homo sapiens_hsa049780.86972994
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85397667
45Vitamin digestion and absorption_Homo sapiens_hsa049770.84176132
46Tight junction_Homo sapiens_hsa045300.80904327
47Proteasome_Homo sapiens_hsa030500.80866420
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79926342
49Staphylococcus aureus infection_Homo sapiens_hsa051500.78587099
50Phototransduction_Homo sapiens_hsa047440.75528613
51Serotonergic synapse_Homo sapiens_hsa047260.75309321
52Wnt signaling pathway_Homo sapiens_hsa043100.71228593
53Nucleotide excision repair_Homo sapiens_hsa034200.70357111
54Asthma_Homo sapiens_hsa053100.70291102
55Alcoholism_Homo sapiens_hsa050340.65784879
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65138376
57Oocyte meiosis_Homo sapiens_hsa041140.64958579
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62643249
59Pancreatic secretion_Homo sapiens_hsa049720.62137305
60Caffeine metabolism_Homo sapiens_hsa002320.61144293
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60054057
62Long-term depression_Homo sapiens_hsa047300.58753586
63RNA transport_Homo sapiens_hsa030130.56615660
64Glutathione metabolism_Homo sapiens_hsa004800.56060173
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55499544
66Tyrosine metabolism_Homo sapiens_hsa003500.53515538
67Tryptophan metabolism_Homo sapiens_hsa003800.51570811
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51244241
69Metabolic pathways_Homo sapiens_hsa011000.50338321
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47813315
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.46979497
72Endocytosis_Homo sapiens_hsa041440.46970865
73Apoptosis_Homo sapiens_hsa042100.46028136
74Renal cell carcinoma_Homo sapiens_hsa052110.45922565
75Ras signaling pathway_Homo sapiens_hsa040140.45178731
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45159130
77Renin-angiotensin system_Homo sapiens_hsa046140.44664176
78Oxytocin signaling pathway_Homo sapiens_hsa049210.44313105
79Choline metabolism in cancer_Homo sapiens_hsa052310.44017755
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43638502
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41182787
82Platelet activation_Homo sapiens_hsa046110.40784345
83Gastric acid secretion_Homo sapiens_hsa049710.39705236
84GnRH signaling pathway_Homo sapiens_hsa049120.38917904
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38016003
86TGF-beta signaling pathway_Homo sapiens_hsa043500.36546354
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35059767
88Inositol phosphate metabolism_Homo sapiens_hsa005620.34647017
89Amoebiasis_Homo sapiens_hsa051460.33696347
90MAPK signaling pathway_Homo sapiens_hsa040100.30963215
91RNA degradation_Homo sapiens_hsa030180.29342874
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27845459
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.25472016
94Salivary secretion_Homo sapiens_hsa049700.24226775
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23749660
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23252173
97Glutamatergic synapse_Homo sapiens_hsa047240.22655485
98Calcium signaling pathway_Homo sapiens_hsa040200.22414893
99Rheumatoid arthritis_Homo sapiens_hsa053230.21137679
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19570307

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