

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 7.14266857 |
| 2 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 7.14266857 |
| 3 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.42952375 |
| 4 | type I interferon signaling pathway (GO:0060337) | 6.30397125 |
| 5 | cellular response to type I interferon (GO:0071357) | 6.30397125 |
| 6 | response to type I interferon (GO:0034340) | 6.27461821 |
| 7 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.97389247 |
| 8 | response to interferon-alpha (GO:0035455) | 5.61955902 |
| 9 | positive regulation of interferon-alpha production (GO:0032727) | 5.41117994 |
| 10 | regulation of interferon-alpha production (GO:0032647) | 5.10752187 |
| 11 | response to interferon-beta (GO:0035456) | 4.79695933 |
| 12 | negative regulation of viral genome replication (GO:0045071) | 4.78181390 |
| 13 | cellular response to interferon-beta (GO:0035458) | 4.66709033 |
| 14 | immunoglobulin mediated immune response (GO:0016064) | 4.66015564 |
| 15 | defense response to protozoan (GO:0042832) | 4.64235854 |
| 16 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 4.63917179 |
| 17 | interferon-gamma-mediated signaling pathway (GO:0060333) | 4.57663721 |
| 18 | cellular response to interferon-alpha (GO:0035457) | 4.53390224 |
| 19 | modulation by symbiont of host immune response (GO:0052553) | 4.35736158 |
| 20 | positive regulation by symbiont of host defense response (GO:0052509) | 4.35736158 |
| 21 | modulation by symbiont of host defense response (GO:0052031) | 4.35736158 |
| 22 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.35736158 |
| 23 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.35736158 |
| 24 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.35736158 |
| 25 | positive regulation of natural killer cell differentiation (GO:0032825) | 4.26330698 |
| 26 | cellular response to exogenous dsRNA (GO:0071360) | 4.22338928 |
| 27 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.19389487 |
| 28 | T cell migration (GO:0072678) | 4.13123279 |
| 29 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.12279706 |
| 30 | response to protozoan (GO:0001562) | 4.06443197 |
| 31 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.95457344 |
| 32 | response to peptidoglycan (GO:0032494) | 3.94813978 |
| 33 | neutrophil activation involved in immune response (GO:0002283) | 3.94509584 |
| 34 | detection of bacterium (GO:0016045) | 3.93708321 |
| 35 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.93632065 |
| 36 | detection of other organism (GO:0098543) | 3.93194887 |
| 37 | positive regulation of interferon-beta production (GO:0032728) | 3.91115633 |
| 38 | myeloid dendritic cell differentiation (GO:0043011) | 3.77675555 |
| 39 | mature B cell differentiation involved in immune response (GO:0002313) | 3.76492979 |
| 40 | negative regulation of interleukin-12 production (GO:0032695) | 3.76478425 |
| 41 | regulation of RIG-I signaling pathway (GO:0039535) | 3.76437273 |
| 42 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.75161359 |
| 43 | cellular response to virus (GO:0098586) | 3.72862794 |
| 44 | B cell mediated immunity (GO:0019724) | 3.71396524 |
| 45 | positive regulation of cAMP-mediated signaling (GO:0043950) | 3.69873448 |
| 46 | cellular response to interferon-gamma (GO:0071346) | 3.69518049 |
| 47 | natural killer cell mediated immunity (GO:0002228) | 3.67096887 |
| 48 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.67096887 |
| 49 | positive regulation of antigen processing and presentation (GO:0002579) | 3.63372749 |
| 50 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.61803061 |
| 51 | myeloid dendritic cell activation (GO:0001773) | 3.57107893 |
| 52 | aggressive behavior (GO:0002118) | 3.52609345 |
| 53 | respiratory burst (GO:0045730) | 3.52522416 |
| 54 | defense response to virus (GO:0051607) | 3.51238407 |
| 55 | T-helper 1 type immune response (GO:0042088) | 3.49237524 |
| 56 | negative regulation of cell killing (GO:0031342) | 3.46917108 |
| 57 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.46917108 |
| 58 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.44627417 |
| 59 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.44491306 |
| 60 | lymphocyte chemotaxis (GO:0048247) | 3.42893029 |
| 61 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.42186374 |
| 62 | response to interferon-gamma (GO:0034341) | 3.41210767 |
| 63 | regulation of hypersensitivity (GO:0002883) | 3.40117842 |
| 64 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.36205693 |
| 65 | regulation of T cell tolerance induction (GO:0002664) | 3.33990256 |
| 66 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.33542698 |
| 67 | regulation of antigen processing and presentation (GO:0002577) | 3.30373781 |
| 68 | positive regulation of T cell cytokine production (GO:0002726) | 3.29653027 |
| 69 | regulation of tolerance induction (GO:0002643) | 3.23774331 |
| 70 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.22921761 |
| 71 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.22765265 |
| 72 | detection of external biotic stimulus (GO:0098581) | 3.21821322 |
| 73 | regulation of natural killer cell differentiation (GO:0032823) | 3.18549370 |
| 74 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.18036806 |
| 75 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.17877689 |
| 76 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.17420201 |
| 77 | regulation of type 2 immune response (GO:0002828) | 3.17101947 |
| 78 | response to host immune response (GO:0052572) | 3.13587168 |
| 79 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.13587168 |
| 80 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.11164323 |
| 81 | positive regulation of interleukin-17 production (GO:0032740) | 3.10141110 |
| 82 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 3.10078796 |
| 83 | regulation of chemokine biosynthetic process (GO:0045073) | 3.09305070 |
| 84 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.07881583 |
| 85 | macrophage activation involved in immune response (GO:0002281) | 3.06532877 |
| 86 | dendritic cell differentiation (GO:0097028) | 3.06045174 |
| 87 | regulation of defense response to virus by host (GO:0050691) | 3.05142977 |
| 88 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.04227685 |
| 89 | positive regulation of interleukin-10 production (GO:0032733) | 3.03988795 |
| 90 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.03874833 |
| 91 | regulation of mast cell degranulation (GO:0043304) | 3.02906089 |
| 92 | microglial cell activation (GO:0001774) | 3.02731921 |
| 93 | positive regulation of type 2 immune response (GO:0002830) | 3.01790222 |
| 94 | granulocyte activation (GO:0036230) | 3.01411105 |
| 95 | regulation of response to interferon-gamma (GO:0060330) | 3.01081189 |
| 96 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.01025013 |
| 97 | positive regulation of T-helper cell differentiation (GO:0045624) | 3.00737885 |
| 98 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.00644226 |
| 99 | positive thymic T cell selection (GO:0045059) | 2.99185681 |
| 100 | response to muramyl dipeptide (GO:0032495) | 2.98880836 |
| 101 | positive regulation of interleukin-12 production (GO:0032735) | 2.97426831 |
| 102 | regulation of viral genome replication (GO:0045069) | 2.96431923 |
| 103 | neutrophil activation (GO:0042119) | 2.93667834 |
| 104 | NIK/NF-kappaB signaling (GO:0038061) | 2.93031532 |
| 105 | regulation of interferon-beta production (GO:0032648) | 2.92054344 |
| 106 | positive regulation of B cell mediated immunity (GO:0002714) | 2.91542349 |
| 107 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.91542349 |
| 108 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.91495880 |
| 109 | regulation of interleukin-10 production (GO:0032653) | 2.89891634 |
| 110 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.89614874 |
| 111 | mature B cell differentiation (GO:0002335) | 2.88971885 |
| 112 | negative regulation of viral process (GO:0048525) | 2.88289215 |
| 113 | detection of biotic stimulus (GO:0009595) | 2.87155241 |
| 114 | myeloid cell activation involved in immune response (GO:0002275) | 2.87012330 |
| 115 | regulation of gamma-delta T cell activation (GO:0046643) | 2.86998154 |
| 116 | JAK-STAT cascade (GO:0007259) | 2.85442265 |
| 117 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.85436097 |
| 118 | positive regulation of mast cell degranulation (GO:0043306) | 2.85436097 |
| 119 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.85189292 |
| 120 | lymphocyte mediated immunity (GO:0002449) | 2.85121884 |
| 121 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 2.84541937 |
| 122 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.84427887 |
| 123 | positive regulation of isotype switching (GO:0045830) | 2.83707728 |
| 124 | positive regulation of defense response to virus by host (GO:0002230) | 2.81578830 |
| 125 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 2.81362550 |
| 126 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.81242247 |
| 127 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.81135752 |
| 128 | response to host (GO:0075136) | 2.81135752 |
| 129 | response to host defenses (GO:0052200) | 2.81135752 |
| 130 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.80014520 |
| 131 | natural killer cell differentiation (GO:0001779) | 2.79754656 |
| 132 | positive regulation of B cell differentiation (GO:0045579) | 2.79478650 |
| 133 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.79441353 |
| 134 | regulation of B cell differentiation (GO:0045577) | 2.77188638 |
| 135 | female mating behavior (GO:0060180) | 2.77126482 |
| 136 | positive regulation of tolerance induction (GO:0002645) | 2.77095420 |
| 137 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.77033519 |
| 138 | reactive oxygen species biosynthetic process (GO:1903409) | 2.77018813 |
| 139 | regulation of female receptivity (GO:0045924) | 2.75342155 |
| 140 | positive regulation of neutrophil chemotaxis (GO:0090023) | 2.73774160 |
| 141 | positive regulation of neutrophil migration (GO:1902624) | 2.73774160 |
| 142 | regulation of mast cell activation (GO:0033003) | 2.73736970 |
| 143 | regulation of interleukin-12 production (GO:0032655) | 2.73105374 |
| 144 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.72885223 |
| 145 | regulation of T-helper cell differentiation (GO:0045622) | 2.72786890 |
| 146 | detection of molecule of bacterial origin (GO:0032490) | 2.72393477 |
| 147 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.72324364 |
| 148 | Peyers patch development (GO:0048541) | 2.72324364 |
| 149 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.70895970 |
| 150 | B cell receptor signaling pathway (GO:0050853) | 2.70640305 |
| 151 | regulation of interleukin-17 production (GO:0032660) | 2.70497467 |
| 152 | positive regulation of T cell migration (GO:2000406) | 2.68508319 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 7.90842247 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 6.68689244 |
| 3 | * IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 5.96498835 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 5.62905962 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.81105221 |
| 6 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.74753253 |
| 7 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.29182610 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.26708420 |
| 9 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.23122387 |
| 10 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.20659825 |
| 11 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.18572499 |
| 12 | GATA1_22025678_ChIP-Seq_K562_Human | 3.09313396 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.02394776 |
| 14 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.82465975 |
| 15 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.75094541 |
| 16 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.64724192 |
| 17 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.48804882 |
| 18 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.46580242 |
| 19 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.44168624 |
| 20 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.21655482 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.17888801 |
| 22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.08437576 |
| 23 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.07558875 |
| 24 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.06570968 |
| 25 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.03189099 |
| 26 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.02410491 |
| 27 | MYB_26560356_Chip-Seq_TH2_Human | 1.99827455 |
| 28 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.96923565 |
| 29 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.92149820 |
| 30 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.88773752 |
| 31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.86232779 |
| 32 | MAF_26560356_Chip-Seq_TH1_Human | 1.82912217 |
| 33 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.73568570 |
| 34 | * MYB_26560356_Chip-Seq_TH1_Human | 1.69960181 |
| 35 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.65719926 |
| 36 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.64282701 |
| 37 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.63420196 |
| 38 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.56274878 |
| 39 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.51569459 |
| 40 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.50087765 |
| 41 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.50084376 |
| 42 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.49317626 |
| 43 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.47136734 |
| 44 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.43410728 |
| 45 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.41801086 |
| 46 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39190854 |
| 47 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.38611031 |
| 48 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37780506 |
| 49 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.37489912 |
| 50 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.37375809 |
| 51 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35659200 |
| 52 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.34545708 |
| 53 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.33994083 |
| 54 | UTX_26944678_Chip-Seq_JUKART_Human | 1.33639377 |
| 55 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30755591 |
| 56 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.29843341 |
| 57 | MYC_22102868_ChIP-Seq_BL_Human | 1.29819992 |
| 58 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.29062392 |
| 59 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.26128157 |
| 60 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.23810749 |
| 61 | MAF_26560356_Chip-Seq_TH2_Human | 1.22868194 |
| 62 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.21296348 |
| 63 | GATA3_26560356_Chip-Seq_TH2_Human | 1.20329162 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.20180647 |
| 65 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19931095 |
| 66 | SPI1_23127762_ChIP-Seq_K562_Human | 1.19415517 |
| 67 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.17280724 |
| 68 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.17129129 |
| 69 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.16923035 |
| 70 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.16819446 |
| 71 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.16297310 |
| 72 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.13570172 |
| 73 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.13253548 |
| 74 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.12513674 |
| 75 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.12483491 |
| 76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.12366793 |
| 77 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.10638085 |
| 78 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.09968267 |
| 79 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.08831085 |
| 80 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.08064373 |
| 81 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07991216 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.07240509 |
| 83 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.05894751 |
| 84 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.04807826 |
| 85 | * PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.02926215 |
| 86 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00434766 |
| 87 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.98444289 |
| 88 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.98191744 |
| 89 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97908020 |
| 90 | P300_27268052_Chip-Seq_Bcells_Human | 0.97135877 |
| 91 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.88681862 |
| 92 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.88334452 |
| 93 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.88148600 |
| 94 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.86591348 |
| 95 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.85259606 |
| 96 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.85077746 |
| 97 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.84011121 |
| 98 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.81029998 |
| 99 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.80813255 |
| 100 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.79965375 |
| 101 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.78570483 |
| 102 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.77891591 |
| 103 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.77697868 |
| 104 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.77628360 |
| 105 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75887148 |
| 106 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.74778228 |
| 107 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.72519077 |
| 108 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.68323785 |
| 109 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.67657863 |
| 110 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.66318566 |
| 111 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.65783308 |
| 112 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.65556051 |
| 113 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.64956391 |
| 114 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.64761865 |
| 115 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.64617099 |
| 116 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.62038005 |
| 117 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.61460118 |
| 118 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.60807258 |
| 119 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.59798264 |
| 120 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.59775469 |
| 121 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.58508755 |
| 122 | GATA1_19941826_ChIP-Seq_K562_Human | 0.55888913 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.91699149 |
| 2 | MP0009785_altered_susceptibility_to | 4.33270742 |
| 3 | MP0003436_decreased_susceptibility_to | 3.59289349 |
| 4 | MP0005671_abnormal_response_to | 3.43822188 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 3.37364963 |
| 6 | MP0003724_increased_susceptibility_to | 3.35919022 |
| 7 | MP0005025_abnormal_response_to | 3.30180793 |
| 8 | MP0000685_abnormal_immune_system | 3.29595781 |
| 9 | MP0006082_CNS_inflammation | 3.26888086 |
| 10 | MP0005000_abnormal_immune_tolerance | 3.18208126 |
| 11 | MP0005387_immune_system_phenotype | 3.17350881 |
| 12 | MP0001790_abnormal_immune_system | 3.17350881 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 3.15690555 |
| 14 | MP0004510_myositis | 2.97803468 |
| 15 | MP0001800_abnormal_humoral_immune | 2.88165760 |
| 16 | MP0002419_abnormal_innate_immunity | 2.80827147 |
| 17 | MP0002452_abnormal_antigen_presenting | 2.77150383 |
| 18 | MP0002723_abnormal_immune_serum | 2.75231717 |
| 19 | MP0003303_peritoneal_inflammation | 2.74387815 |
| 20 | MP0001819_abnormal_immune_cell | 2.43863492 |
| 21 | MP0002420_abnormal_adaptive_immunity | 2.39350063 |
| 22 | MP0002166_altered_tumor_susceptibility | 2.10549201 |
| 23 | MP0005464_abnormal_platelet_physiology | 2.09261179 |
| 24 | MP0004947_skin_inflammation | 2.04681550 |
| 25 | MP0002006_tumorigenesis | 2.01796664 |
| 26 | MP0001853_heart_inflammation | 1.99623352 |
| 27 | MP0002398_abnormal_bone_marrow | 1.98130040 |
| 28 | MP0001533_abnormal_skeleton_physiology | 1.96132745 |
| 29 | MP0010155_abnormal_intestine_physiology | 1.95319710 |
| 30 | MP0001845_abnormal_inflammatory_respons | 1.92889575 |
| 31 | MP0000716_abnormal_immune_system | 1.92627955 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 1.92432599 |
| 33 | MP0001545_abnormal_hematopoietic_system | 1.91029772 |
| 34 | MP0005397_hematopoietic_system_phenotyp | 1.91029772 |
| 35 | MP0003763_abnormal_thymus_physiology | 1.87401556 |
| 36 | MP0008469_abnormal_protein_level | 1.85615003 |
| 37 | MP0005058_abnormal_lysosome_morphology | 1.81083306 |
| 38 | MP0005451_abnormal_body_composition | 1.79981884 |
| 39 | MP0009764_decreased_sensitivity_to | 1.77873599 |
| 40 | MP0003448_altered_tumor_morphology | 1.73379541 |
| 41 | MP0003191_abnormal_cellular_cholesterol | 1.66296780 |
| 42 | MP0002405_respiratory_system_inflammati | 1.65830170 |
| 43 | MP0009278_abnormal_bone_marrow | 1.65213020 |
| 44 | MP0000689_abnormal_spleen_morphology | 1.64684431 |
| 45 | MP0002429_abnormal_blood_cell | 1.58014135 |
| 46 | MP0002722_abnormal_immune_system | 1.53972624 |
| 47 | MP0009840_abnormal_foam_cell | 1.53741468 |
| 48 | MP0005645_abnormal_hypothalamus_physiol | 1.47531507 |
| 49 | MP0008004_abnormal_stomach_pH | 1.46858703 |
| 50 | MP0003183_abnormal_peptide_metabolism | 1.44224812 |
| 51 | MP0002132_abnormal_respiratory_system | 1.43751051 |
| 52 | MP0005310_abnormal_salivary_gland | 1.42194447 |
| 53 | MP0004808_abnormal_hematopoietic_stem | 1.34963743 |
| 54 | MP0003172_abnormal_lysosome_physiology | 1.34179499 |
| 55 | MP0000858_altered_metastatic_potential | 1.30816801 |
| 56 | MP0002396_abnormal_hematopoietic_system | 1.27018966 |
| 57 | MP0000343_altered_response_to | 1.25653341 |
| 58 | MP0003075_altered_response_to | 1.22514288 |
| 59 | MP0003300_gastrointestinal_ulcer | 1.18610927 |
| 60 | MP0010307_abnormal_tumor_latency | 1.12372546 |
| 61 | MP0002998_abnormal_bone_remodeling | 1.12095605 |
| 62 | MP0003186_abnormal_redox_activity | 1.11867085 |
| 63 | MP0000604_amyloidosis | 1.11664762 |
| 64 | MP0004782_abnormal_surfactant_physiolog | 1.11517357 |
| 65 | MP0009763_increased_sensitivity_to | 1.08358090 |
| 66 | MP0002139_abnormal_hepatobiliary_system | 1.05886720 |
| 67 | MP0001873_stomach_inflammation | 1.05511941 |
| 68 | MP0000703_abnormal_thymus_morphology | 1.04003451 |
| 69 | MP0005174_abnormal_tail_pigmentation | 1.02305089 |
| 70 | MP0002933_joint_inflammation | 1.01737993 |
| 71 | MP0002277_abnormal_respiratory_mucosa | 1.00263416 |
| 72 | MP0005166_decreased_susceptibility_to | 0.88754066 |
| 73 | MP0000490_abnormal_crypts_of | 0.87843699 |
| 74 | MP0001851_eye_inflammation | 0.85576212 |
| 75 | MP0005165_increased_susceptibility_to | 0.85219356 |
| 76 | MP0006036_abnormal_mitochondrial_physio | 0.84535986 |
| 77 | MP0005390_skeleton_phenotype | 0.83640778 |
| 78 | MP0005164_abnormal_response_to | 0.83491982 |
| 79 | MP0003866_abnormal_defecation | 0.80773425 |
| 80 | MP0005167_abnormal_blood-brain_barrier | 0.80137526 |
| 81 | MP0000465_gastrointestinal_hemorrhage | 0.76815464 |
| 82 | MP0002019_abnormal_tumor_incidence | 0.71835524 |
| 83 | MP0005535_abnormal_body_temperature | 0.71207831 |
| 84 | MP0003656_abnormal_erythrocyte_physiolo | 0.65408647 |
| 85 | MP0003453_abnormal_keratinocyte_physiol | 0.65360931 |
| 86 | MP0002136_abnormal_kidney_physiology | 0.63584597 |
| 87 | MP0009765_abnormal_xenobiotic_induced | 0.62969992 |
| 88 | MP0000249_abnormal_blood_vessel | 0.61704224 |
| 89 | MP0005367_renal/urinary_system_phenotyp | 0.60531018 |
| 90 | MP0000516_abnormal_urinary_system | 0.60531018 |
| 91 | MP0008260_abnormal_autophagy | 0.60191096 |
| 92 | MP0005319_abnormal_enzyme/_coenzyme | 0.59648922 |
| 93 | MP0002254_reproductive_system_inflammat | 0.58553609 |
| 94 | MP0004858_abnormal_nervous_system | 0.57275559 |
| 95 | MP0005075_abnormal_melanosome_morpholog | 0.57273521 |
| 96 | MP0004883_abnormal_blood_vessel | 0.56762127 |
| 97 | MP0003828_pulmonary_edema | 0.56269147 |
| 98 | MP0005023_abnormal_wound_healing | 0.56009422 |
| 99 | MP0002693_abnormal_pancreas_physiology | 0.55860440 |
| 100 | MP0001663_abnormal_digestive_system | 0.54589668 |
| 101 | MP0000015_abnormal_ear_pigmentation | 0.54210720 |
| 102 | MP0000598_abnormal_liver_morphology | 0.53876210 |
| 103 | MP0000609_abnormal_liver_physiology | 0.52460397 |
| 104 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.52252490 |
| 105 | MP0008874_decreased_physiological_sensi | 0.51322471 |
| 106 | MP0010352_gastrointestinal_tract_polyps | 0.50747562 |
| 107 | MP0009643_abnormal_urine_homeostasis | 0.50743989 |
| 108 | MP0002138_abnormal_hepatobiliary_system | 0.50267224 |
| 109 | MP0005381_digestive/alimentary_phenotyp | 0.50255576 |
| 110 | MP0009379_abnormal_foot_pigmentation | 0.50150317 |
| 111 | MP0003795_abnormal_bone_structure | 0.49979298 |
| 112 | MP0008873_increased_physiological_sensi | 0.48775760 |
| 113 | MP0001986_abnormal_taste_sensitivity | 0.48010848 |
| 114 | MP0003943_abnormal_hepatobiliary_system | 0.47203665 |
| 115 | MP0009697_abnormal_copulation | 0.47043742 |
| 116 | MP0003690_abnormal_glial_cell | 0.44173155 |
| 117 | MP0000372_irregular_coat_pigmentation | 0.42731312 |
| 118 | MP0003045_fibrosis | 0.41776420 |
| 119 | MP0001881_abnormal_mammary_gland | 0.41269395 |
| 120 | MP0001764_abnormal_homeostasis | 0.40513595 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 6.04432976 |
| 2 | Chronic otitis media (HP:0000389) | 6.00870140 |
| 3 | Eczematoid dermatitis (HP:0000976) | 5.90506956 |
| 4 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.79694242 |
| 5 | Recurrent bacterial skin infections (HP:0005406) | 5.70170093 |
| 6 | Autoimmune thrombocytopenia (HP:0001973) | 4.74565480 |
| 7 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.49962960 |
| 8 | Agammaglobulinemia (HP:0004432) | 4.44710437 |
| 9 | Nasal polyposis (HP:0100582) | 4.42573934 |
| 10 | Abnormality of macrophages (HP:0004311) | 4.42538526 |
| 11 | Mediastinal lymphadenopathy (HP:0100721) | 4.31517736 |
| 12 | Myositis (HP:0100614) | 4.26679805 |
| 13 | Increased IgM level (HP:0003496) | 4.25229358 |
| 14 | Abnormality of the nasal mucosa (HP:0000433) | 4.06306097 |
| 15 | Recurrent bronchitis (HP:0002837) | 3.99660622 |
| 16 | Recurrent viral infections (HP:0004429) | 3.84855701 |
| 17 | Recurrent skin infections (HP:0001581) | 3.82217673 |
| 18 | Recurrent fungal infections (HP:0002841) | 3.76589849 |
| 19 | Abnormality of B cell number (HP:0010975) | 3.69344688 |
| 20 | Vasculitis (HP:0002633) | 3.66046551 |
| 21 | Hypergammaglobulinemia (HP:0010702) | 3.64136080 |
| 22 | Basal ganglia calcification (HP:0002135) | 3.51009519 |
| 23 | B lymphocytopenia (HP:0010976) | 3.46683573 |
| 24 | Vacuolated lymphocytes (HP:0001922) | 3.45434266 |
| 25 | Orchitis (HP:0100796) | 3.44979048 |
| 26 | Interstitial pulmonary disease (HP:0006530) | 3.38223785 |
| 27 | Stomatitis (HP:0010280) | 3.32467096 |
| 28 | Increased cerebral lipofuscin (HP:0011813) | 3.27901001 |
| 29 | Chest pain (HP:0100749) | 3.25461835 |
| 30 | Petechiae (HP:0000967) | 3.25050133 |
| 31 | Systemic lupus erythematosus (HP:0002725) | 3.22870601 |
| 32 | Chronic sinusitis (HP:0011109) | 3.21524413 |
| 33 | Pustule (HP:0200039) | 3.20733166 |
| 34 | Chronic obstructive pulmonary disease (HP:0006510) | 3.19418650 |
| 35 | Obstructive lung disease (HP:0006536) | 3.19418650 |
| 36 | Thrombocytosis (HP:0001894) | 3.17733462 |
| 37 | Cellulitis (HP:0100658) | 3.07968117 |
| 38 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.05446410 |
| 39 | Recurrent cutaneous fungal infections (HP:0011370) | 3.05446410 |
| 40 | Gingivitis (HP:0000230) | 3.04719966 |
| 41 | Retrobulbar optic neuritis (HP:0100654) | 3.04611926 |
| 42 | Optic neuritis (HP:0100653) | 3.04611926 |
| 43 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.02998013 |
| 44 | Periodontitis (HP:0000704) | 2.95118613 |
| 45 | Abnormality of the pleura (HP:0002103) | 2.89780376 |
| 46 | Abnormality of T cell physiology (HP:0011840) | 2.85074837 |
| 47 | Gingival bleeding (HP:0000225) | 2.80444246 |
| 48 | Abnormality of T cells (HP:0002843) | 2.80159066 |
| 49 | Meningitis (HP:0001287) | 2.73209359 |
| 50 | Severe combined immunodeficiency (HP:0004430) | 2.70947071 |
| 51 | Autoimmune hemolytic anemia (HP:0001890) | 2.70658840 |
| 52 | Keratoconjunctivitis sicca (HP:0001097) | 2.67286896 |
| 53 | Increased IgE level (HP:0003212) | 2.64965041 |
| 54 | Abnormality of T cell number (HP:0011839) | 2.62419320 |
| 55 | Purpura (HP:0000979) | 2.61823629 |
| 56 | Skin rash (HP:0000988) | 2.58610854 |
| 57 | Pulmonary infiltrates (HP:0002113) | 2.58427890 |
| 58 | IgM deficiency (HP:0002850) | 2.57047255 |
| 59 | Gangrene (HP:0100758) | 2.55743499 |
| 60 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.53462005 |
| 61 | Amaurosis fugax (HP:0100576) | 2.51153575 |
| 62 | Urticaria (HP:0001025) | 2.50264919 |
| 63 | Keratoconjunctivitis (HP:0001096) | 2.48583528 |
| 64 | T lymphocytopenia (HP:0005403) | 2.48328732 |
| 65 | Prostate neoplasm (HP:0100787) | 2.45757454 |
| 66 | IgG deficiency (HP:0004315) | 2.45269339 |
| 67 | Tetraparesis (HP:0002273) | 2.44096314 |
| 68 | Pulmonary embolism (HP:0002204) | 2.43359779 |
| 69 | Loss of speech (HP:0002371) | 2.43211871 |
| 70 | Leukocytosis (HP:0001974) | 2.42841615 |
| 71 | Porencephaly (HP:0002132) | 2.37897426 |
| 72 | Recurrent pneumonia (HP:0006532) | 2.37323173 |
| 73 | Emphysema (HP:0002097) | 2.35523050 |
| 74 | Spontaneous hematomas (HP:0007420) | 2.33664524 |
| 75 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.33478137 |
| 76 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.33478137 |
| 77 | Abnormality of glycolipid metabolism (HP:0010969) | 2.33478137 |
| 78 | Recurrent lower respiratory tract infections (HP:0002783) | 2.33214435 |
| 79 | Thrombophlebitis (HP:0004418) | 2.32458899 |
| 80 | Amyloidosis (HP:0011034) | 2.31813964 |
| 81 | Hemoptysis (HP:0002105) | 2.31399823 |
| 82 | Hepatosplenomegaly (HP:0001433) | 2.31132801 |
| 83 | Lymphopenia (HP:0001888) | 2.30747620 |
| 84 | Epistaxis (HP:0000421) | 2.30684696 |
| 85 | Osteomyelitis (HP:0002754) | 2.29881346 |
| 86 | Poor head control (HP:0002421) | 2.28751746 |
| 87 | Hypertensive crisis (HP:0100735) | 2.28671965 |
| 88 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.28282567 |
| 89 | Vertigo (HP:0002321) | 2.28176823 |
| 90 | Gastrointestinal infarctions (HP:0005244) | 2.27345669 |
| 91 | Premature loss of primary teeth (HP:0006323) | 2.27207042 |
| 92 | Abnormality of the prostate (HP:0008775) | 2.26994325 |
| 93 | Sepsis (HP:0100806) | 2.24998379 |
| 94 | Abnormality of male internal genitalia (HP:0000022) | 2.23080733 |
| 95 | Hematochezia (HP:0002573) | 2.22930293 |
| 96 | Arterial thrombosis (HP:0004420) | 2.21687642 |
| 97 | Combined immunodeficiency (HP:0005387) | 2.21520893 |
| 98 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.19434788 |
| 99 | Stomach cancer (HP:0012126) | 2.18760144 |
| 100 | IgA deficiency (HP:0002720) | 2.18102515 |
| 101 | Bronchitis (HP:0012387) | 2.17515112 |
| 102 | Prolonged bleeding time (HP:0003010) | 2.16980305 |
| 103 | Cleft eyelid (HP:0000625) | 2.16753534 |
| 104 | Gastrointestinal inflammation (HP:0004386) | 2.16686775 |
| 105 | Inflammation of the large intestine (HP:0002037) | 2.14697530 |
| 106 | Gastrointestinal stroma tumor (HP:0100723) | 2.14166809 |
| 107 | Skin ulcer (HP:0200042) | 2.12568821 |
| 108 | Glomerulonephritis (HP:0000099) | 2.11979630 |
| 109 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.11094219 |
| 110 | Eosinophilia (HP:0001880) | 2.08663228 |
| 111 | Polyneuropathy (HP:0001271) | 2.08423142 |
| 112 | Colitis (HP:0002583) | 2.07797582 |
| 113 | Abnormality of eosinophils (HP:0001879) | 2.07530341 |
| 114 | Panhypogammaglobulinemia (HP:0003139) | 2.07527625 |
| 115 | Xerostomia (HP:0000217) | 2.07136360 |
| 116 | Spontaneous abortion (HP:0005268) | 2.06790965 |
| 117 | Chronic diarrhea (HP:0002028) | 2.06703209 |
| 118 | Encephalitis (HP:0002383) | 2.06102362 |
| 119 | Increased serum ferritin (HP:0003281) | 2.04449104 |
| 120 | Joint swelling (HP:0001386) | 2.04295287 |
| 121 | Episodic fever (HP:0001954) | 2.03889982 |
| 122 | Anorexia (HP:0002039) | 2.02135948 |
| 123 | Glomerulopathy (HP:0100820) | 1.99332540 |
| 124 | Lymphoma (HP:0002665) | 1.98639733 |
| 125 | Thyroiditis (HP:0100646) | 1.98062786 |
| 126 | Neutropenia (HP:0001875) | 1.94949698 |
| 127 | Granulocytopenia (HP:0001913) | 1.93332545 |
| 128 | Abnormality of the pericardium (HP:0001697) | 1.92419887 |
| 129 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.91388961 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TYK2 | 3.94202742 |
| 2 | TBK1 | 3.83932504 |
| 3 | IKBKE | 3.63389015 |
| 4 | MAP3K14 | 3.28801422 |
| 5 | KIT | 3.27403405 |
| 6 | BLK | 3.24795800 |
| 7 | JAK3 | 3.04996348 |
| 8 | MAP4K1 | 2.94610498 |
| 9 | IRAK4 | 2.89990823 |
| 10 | PBK | 2.83492453 |
| 11 | SCYL2 | 2.73856162 |
| 12 | PIM2 | 2.66359694 |
| 13 | FGFR4 | 2.60076590 |
| 14 | TXK | 2.57671408 |
| 15 | TESK2 | 2.45689452 |
| 16 | JAK1 | 2.31454115 |
| 17 | ERN1 | 2.31128212 |
| 18 | RIPK4 | 2.28297940 |
| 19 | IKBKB | 2.11476887 |
| 20 | ZAP70 | 2.06264921 |
| 21 | NME2 | 1.96729459 |
| 22 | IRAK3 | 1.72500544 |
| 23 | SYK | 1.68931630 |
| 24 | TEC | 1.59937788 |
| 25 | BTK | 1.57990069 |
| 26 | FGFR3 | 1.50023814 |
| 27 | EPHA3 | 1.44833439 |
| 28 | MATK | 1.44599541 |
| 29 | IRAK1 | 1.36247270 |
| 30 | NLK | 1.33321960 |
| 31 | EPHB1 | 1.33128509 |
| 32 | CSK | 1.33110969 |
| 33 | CDK19 | 1.31651605 |
| 34 | LCK | 1.27839359 |
| 35 | HCK | 1.22464330 |
| 36 | NUAK1 | 1.20884117 |
| 37 | MST4 | 1.20221965 |
| 38 | RPS6KA4 | 1.19812381 |
| 39 | TGFBR2 | 1.18678515 |
| 40 | PIM1 | 1.17080410 |
| 41 | MAP3K13 | 1.17047873 |
| 42 | CSF1R | 1.14539333 |
| 43 | CHUK | 1.14125199 |
| 44 | LYN | 1.12215476 |
| 45 | MAP2K3 | 1.10176871 |
| 46 | TAOK2 | 1.03650211 |
| 47 | TAOK3 | 1.02726859 |
| 48 | JAK2 | 1.02675498 |
| 49 | TLK1 | 0.97337832 |
| 50 | STK10 | 0.90258791 |
| 51 | PIK3CG | 0.88427456 |
| 52 | FES | 0.86166213 |
| 53 | EIF2AK2 | 0.85841357 |
| 54 | MAP3K5 | 0.79497033 |
| 55 | STK4 | 0.79021888 |
| 56 | PRPF4B | 0.73539525 |
| 57 | ZAK | 0.71911734 |
| 58 | IRAK2 | 0.70924154 |
| 59 | NEK9 | 0.70389625 |
| 60 | LRRK2 | 0.70099470 |
| 61 | ABL2 | 0.67540486 |
| 62 | CDC42BPA | 0.66357310 |
| 63 | FLT3 | 0.65780206 |
| 64 | MAP3K12 | 0.65608221 |
| 65 | MUSK | 0.65321557 |
| 66 | SIK2 | 0.64947457 |
| 67 | KDR | 0.64403306 |
| 68 | ITK | 0.64390774 |
| 69 | SIK3 | 0.64201252 |
| 70 | TNIK | 0.63206887 |
| 71 | BMX | 0.62677090 |
| 72 | DAPK1 | 0.62483760 |
| 73 | TGFBR1 | 0.61538839 |
| 74 | VRK2 | 0.60239656 |
| 75 | BMPR2 | 0.59470652 |
| 76 | MARK3 | 0.58016467 |
| 77 | MAP4K2 | 0.55845205 |
| 78 | RAF1 | 0.53381611 |
| 79 | RPS6KA5 | 0.52400818 |
| 80 | ARAF | 0.51667087 |
| 81 | DAPK2 | 0.50361456 |
| 82 | PRKCD | 0.50307687 |
| 83 | MAP3K1 | 0.48502366 |
| 84 | MAP3K11 | 0.47634012 |
| 85 | DYRK1B | 0.47632936 |
| 86 | ABL1 | 0.47415572 |
| 87 | YES1 | 0.46419656 |
| 88 | MAPK11 | 0.46237478 |
| 89 | ADRBK2 | 0.46105541 |
| 90 | CLK1 | 0.45516336 |
| 91 | GRK6 | 0.44054301 |
| 92 | MAP2K2 | 0.42622208 |
| 93 | MAPKAPK3 | 0.42216695 |
| 94 | MAPK4 | 0.40002328 |
| 95 | FGR | 0.39593402 |
| 96 | CAMKK2 | 0.39080288 |
| 97 | EIF2AK3 | 0.36953521 |
| 98 | FYN | 0.36629720 |
| 99 | MYLK | 0.36116569 |
| 100 | PKN2 | 0.35022362 |
| 101 | EIF2AK1 | 0.34206075 |
| 102 | RPS6KB2 | 0.34175300 |
| 103 | CDK4 | 0.33290984 |
| 104 | EGFR | 0.32366941 |
| 105 | GRK7 | 0.32031943 |
| 106 | PRKD2 | 0.31580558 |
| 107 | RPS6KL1 | 0.30446281 |
| 108 | RPS6KC1 | 0.30446281 |
| 109 | ALK | 0.29816049 |
| 110 | MAP3K3 | 0.29644830 |
| 111 | MOS | 0.28935647 |
| 112 | TAOK1 | 0.28820932 |
| 113 | HIPK2 | 0.28606913 |
| 114 | DAPK3 | 0.28559216 |
| 115 | IGF1R | 0.28532571 |
| 116 | PRKCH | 0.27944940 |
| 117 | MAP2K6 | 0.27378414 |
| 118 | RPS6KA6 | 0.27163738 |
| 119 | CCNB1 | 0.26746748 |
| 120 | MAP3K8 | 0.26251398 |
| 121 | TNK2 | 0.25652131 |
| 122 | TESK1 | 0.25553050 |
| 123 | PRKCQ | 0.25252559 |
| 124 | MAPKAPK2 | 0.22179944 |
| 125 | PRKG2 | 0.21002469 |
| 126 | BCKDK | 0.20883217 |
| 127 | RIPK1 | 0.20201277 |
| 128 | CDK6 | 0.17432982 |
| 129 | MAPK3 | 0.16078720 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 3.54795758 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.13734369 |
| 3 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 3.02468641 |
| 4 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 3.01705578 |
| 5 | Allograft rejection_Homo sapiens_hsa05330 | 2.98009596 |
| 6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.69754411 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.68305517 |
| 8 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.59884065 |
| 9 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.54317891 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.52173182 |
| 11 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.50424829 |
| 12 | Influenza A_Homo sapiens_hsa05164 | 2.27503782 |
| 13 | Herpes simplex infection_Homo sapiens_hsa05168 | 2.26591665 |
| 14 | Pertussis_Homo sapiens_hsa05133 | 2.14990393 |
| 15 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.14600643 |
| 16 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.11577254 |
| 17 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.10988821 |
| 18 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.01840782 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.96271712 |
| 20 | Malaria_Homo sapiens_hsa05144 | 1.91492923 |
| 21 | Legionellosis_Homo sapiens_hsa05134 | 1.86215776 |
| 22 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.84325375 |
| 23 | Tuberculosis_Homo sapiens_hsa05152 | 1.78678163 |
| 24 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.69659102 |
| 25 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.66546801 |
| 26 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.58850231 |
| 27 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.58587101 |
| 28 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.51693409 |
| 29 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.48051754 |
| 30 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.47355086 |
| 31 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.42825481 |
| 32 | Hepatitis C_Homo sapiens_hsa05160 | 1.41874412 |
| 33 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.39952104 |
| 34 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.35604203 |
| 35 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.35168705 |
| 36 | Apoptosis_Homo sapiens_hsa04210 | 1.31313672 |
| 37 | Shigellosis_Homo sapiens_hsa05131 | 1.27426191 |
| 38 | Salmonella infection_Homo sapiens_hsa05132 | 1.26694835 |
| 39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.26353914 |
| 40 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.24374756 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.21703036 |
| 42 | Ribosome_Homo sapiens_hsa03010 | 1.19726760 |
| 43 | Lysosome_Homo sapiens_hsa04142 | 1.16448256 |
| 44 | Viral myocarditis_Homo sapiens_hsa05416 | 1.08687783 |
| 45 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.08265214 |
| 46 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.08039468 |
| 47 | Proteasome_Homo sapiens_hsa03050 | 1.05396160 |
| 48 | Other glycan degradation_Homo sapiens_hsa00511 | 1.04546056 |
| 49 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.99369643 |
| 50 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.95840923 |
| 51 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.95690570 |
| 52 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.92776419 |
| 53 | Phagosome_Homo sapiens_hsa04145 | 0.88501560 |
| 54 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.82890089 |
| 55 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82786700 |
| 56 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.80605731 |
| 57 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.76752723 |
| 58 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.73596653 |
| 59 | DNA replication_Homo sapiens_hsa03030 | 0.71693108 |
| 60 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.67260197 |
| 61 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.63173211 |
| 62 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.59747643 |
| 63 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.59178917 |
| 64 | Platelet activation_Homo sapiens_hsa04611 | 0.55866144 |
| 65 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.52830868 |
| 66 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.52060329 |
| 67 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.51710211 |
| 68 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.50829896 |
| 69 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.49628301 |
| 70 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.48589987 |
| 71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.47439167 |
| 72 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.46989466 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46256091 |
| 74 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.45038836 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44858832 |
| 76 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.43691904 |
| 77 | Base excision repair_Homo sapiens_hsa03410 | 0.43339688 |
| 78 | Prion diseases_Homo sapiens_hsa05020 | 0.43066101 |
| 79 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.43062125 |
| 80 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41507997 |
| 81 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40920014 |
| 82 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.40715531 |
| 83 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.38900627 |
| 84 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.37244742 |
| 85 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.35030076 |
| 86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.35016728 |
| 87 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.34793156 |
| 88 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.34739960 |
| 89 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.33990850 |
| 90 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.32426212 |
| 91 | HTLV-I infection_Homo sapiens_hsa05166 | 0.31045418 |
| 92 | Amoebiasis_Homo sapiens_hsa05146 | 0.30875044 |
| 93 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.30656263 |
| 94 | Sulfur relay system_Homo sapiens_hsa04122 | 0.29772804 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.29078398 |
| 96 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.28041616 |
| 97 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.26147273 |
| 98 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.24149041 |
| 99 | Peroxisome_Homo sapiens_hsa04146 | 0.22685104 |
| 100 | Parkinsons disease_Homo sapiens_hsa05012 | 0.21713721 |
| 101 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.21691180 |
| 102 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.21110025 |
| 103 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.21014660 |
| 104 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.19734385 |
| 105 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.19678935 |
| 106 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.18778538 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.17916496 |
| 108 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.17197170 |
| 109 | ABC transporters_Homo sapiens_hsa02010 | 0.16609453 |
| 110 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.16423459 |
| 111 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.15839735 |
| 112 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.15777098 |
| 113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.15435519 |
| 114 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.15409595 |
| 115 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.15217072 |
| 116 | Olfactory transduction_Homo sapiens_hsa04740 | 0.14678254 |
| 117 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.13905722 |
| 118 | Mismatch repair_Homo sapiens_hsa03430 | 0.13281507 |
| 119 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.11794295 |
| 120 | Thyroid cancer_Homo sapiens_hsa05216 | 0.11247061 |
| 121 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.10096460 |
| 122 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.09165230 |
| 123 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.05945508 |
| 124 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.05857473 |
| 125 | Endocytosis_Homo sapiens_hsa04144 | 0.05005465 |
| 126 | Salivary secretion_Homo sapiens_hsa04970 | 0.03057221 |
| 127 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.0045178 |

