FAM27E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)7.10615953
2negative regulation of translation, ncRNA-mediated (GO:0040033)7.10615953
3regulation of translation, ncRNA-mediated (GO:0045974)7.10615953
4regulation of female gonad development (GO:2000194)6.09932536
5pre-miRNA processing (GO:0031054)5.75427264
6nucleoside transmembrane transport (GO:1901642)5.53684494
7response to pheromone (GO:0019236)5.51928205
8regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.51224643
9positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.51224643
10monoubiquitinated protein deubiquitination (GO:0035520)5.28243896
11regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)5.17998490
12positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO5.17998490
13endothelial cell chemotaxis (GO:0035767)5.00118805
14negative regulation by host of viral transcription (GO:0043922)4.96424153
15regulation of sarcomere organization (GO:0060297)4.87166522
16chemosensory behavior (GO:0007635)4.80635397
17negative regulation of telomere maintenance (GO:0032205)4.79780354
18regulation of telomere maintenance via telomerase (GO:0032210)4.71913380
19positive regulation of mRNA catabolic process (GO:0061014)4.15408016
20response to misfolded protein (GO:0051788)4.01597306
21phosphorelay signal transduction system (GO:0000160)3.96766067
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.86750627
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86317853
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82089186
25protein retention in ER lumen (GO:0006621)3.74578179
26serotonin metabolic process (GO:0042428)3.72456889
27nucleoside transport (GO:0015858)3.72295900
28DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.71565052
29negative regulation of glycogen metabolic process (GO:0070874)3.70267032
30auditory receptor cell stereocilium organization (GO:0060088)3.69466931
31mRNA cleavage (GO:0006379)3.69253704
32tachykinin receptor signaling pathway (GO:0007217)3.65182911
33mesenchymal cell differentiation involved in renal system development (GO:2001012)3.57280371
34mesenchymal cell differentiation involved in kidney development (GO:0072161)3.57280371
35regulation of mRNA catabolic process (GO:0061013)3.56713175
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55918607
37prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.47279874
38positive regulation of mRNA 3-end processing (GO:0031442)3.47215459
39negative regulation of hormone biosynthetic process (GO:0032353)3.45064144
40RNA destabilization (GO:0050779)3.42369771
41DNA damage response, signal transduction resulting in transcription (GO:0042772)3.38145973
42primary amino compound metabolic process (GO:1901160)3.32007996
43glycine transport (GO:0015816)3.30684374
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29120354
45ubiquinone biosynthetic process (GO:0006744)3.28920003
46negative regulation of gluconeogenesis (GO:0045721)3.28902880
47DNA methylation involved in gamete generation (GO:0043046)3.27301417
48positive regulation of CREB transcription factor activity (GO:0032793)3.24141029
49positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.22433592
50postsynaptic membrane organization (GO:0001941)3.21437781
51positive regulation of catecholamine secretion (GO:0033605)3.19908684
52retina vasculature morphogenesis in camera-type eye (GO:0061299)3.17529312
53retinoic acid receptor signaling pathway (GO:0048384)3.14333102
54negative regulation of glycogen biosynthetic process (GO:0045719)3.10247289
55negative regulation of acute inflammatory response (GO:0002674)3.09878377
56regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09794698
57regulation of centriole replication (GO:0046599)3.06326184
58respiratory tube development (GO:0030323)3.05785606
59glomerular visceral epithelial cell development (GO:0072015)3.03973921
60cell differentiation involved in metanephros development (GO:0072202)3.02331384
61snRNA processing (GO:0016180)3.01908583
62regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.00739901
63reflex (GO:0060004)2.97378883
64establishment of apical/basal cell polarity (GO:0035089)2.96683719
65positive regulation of digestive system process (GO:0060456)2.94783181
66regulation of gamma-delta T cell differentiation (GO:0045586)2.90965168
67ubiquinone metabolic process (GO:0006743)2.88330352
68membrane depolarization during action potential (GO:0086010)2.87409272
69negative T cell selection (GO:0043383)2.87047598
70cilium or flagellum-dependent cell motility (GO:0001539)2.87002055
71regulation of telomere maintenance (GO:0032204)2.86077572
72negative regulation of hormone metabolic process (GO:0032351)2.85474178
73regulation of type B pancreatic cell apoptotic process (GO:2000674)2.83124213
74multicellular organismal movement (GO:0050879)2.81775987
75musculoskeletal movement (GO:0050881)2.81775987
76protein localization to cilium (GO:0061512)2.81107161
77glomerular epithelial cell development (GO:0072310)2.77832103
78regulation of mRNA 3-end processing (GO:0031440)2.76038148
79modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.73601779
80actin nucleation (GO:0045010)2.72204415
81positive regulation of growth hormone secretion (GO:0060124)2.69936795
82quinone biosynthetic process (GO:1901663)2.69478768
83negative regulation of actin filament bundle assembly (GO:0032232)2.66652282
84protein K48-linked deubiquitination (GO:0071108)2.66459469
85nitric oxide biosynthetic process (GO:0006809)2.66351844
86mitotic sister chromatid cohesion (GO:0007064)2.62685749
87sperm motility (GO:0030317)2.62377302
88gene silencing by RNA (GO:0031047)2.62182333
89collecting duct development (GO:0072044)2.61205288
90indolalkylamine metabolic process (GO:0006586)2.61165114
91snRNA metabolic process (GO:0016073)2.60026172
92misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.59211748
93modulation by host of viral transcription (GO:0043921)2.58795148
94modulation by host of symbiont transcription (GO:0052472)2.58795148
95positive regulation of synapse maturation (GO:0090129)2.58681072
96ovulation cycle (GO:0042698)2.55990122
97positive regulation of defense response to virus by host (GO:0002230)2.55484675
98cranial nerve morphogenesis (GO:0021602)2.54187535
99NAD biosynthetic process (GO:0009435)2.53799062
100indole-containing compound metabolic process (GO:0042430)2.53487176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human3.10787158
2AR_21572438_ChIP-Seq_LNCaP_Human3.02046722
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71746825
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.62271557
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40660959
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38129558
7VDR_22108803_ChIP-Seq_LS180_Human2.33569559
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.32486481
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15811171
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.14676774
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09104979
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.08481637
13EZH2_22144423_ChIP-Seq_EOC_Human10.9878450
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91289311
15ZNF274_21170338_ChIP-Seq_K562_Hela1.84537734
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82123885
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78408200
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67904902
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61747645
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59639946
21GBX2_23144817_ChIP-Seq_PC3_Human1.59607585
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55167280
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.54640113
24RNF2_27304074_Chip-Seq_NSC_Mouse1.50486011
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50183279
26REST_21632747_ChIP-Seq_MESCs_Mouse1.49951340
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49106625
28OCT4_20526341_ChIP-Seq_ESCs_Human1.44099155
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43375737
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43375737
31BCAT_22108803_ChIP-Seq_LS180_Human1.41488812
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37157461
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36763029
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31810068
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30084643
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29977429
37CTCF_27219007_Chip-Seq_Bcells_Human1.26735550
38STAT3_23295773_ChIP-Seq_U87_Human1.26234513
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25279851
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25279851
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22504705
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.19146731
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16118751
44TAF15_26573619_Chip-Seq_HEK293_Human1.14631775
45NFYB_21822215_ChIP-Seq_K562_Human1.14330286
46NFYA_21822215_ChIP-Seq_K562_Human1.10879977
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.10150677
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09762047
49PHF8_20622853_ChIP-Seq_HELA_Human1.08982974
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08405544
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.07585222
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06163820
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.06151298
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05744341
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04566831
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.03640894
57E2F1_20622854_ChIP-Seq_HELA_Human1.03104397
58TCF4_23295773_ChIP-Seq_U87_Human1.02771425
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.02273324
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02210648
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01964986
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00335694
63ER_23166858_ChIP-Seq_MCF-7_Human1.00184801
64ETV1_20927104_ChIP-Seq_GIST48_Human0.98857703
65MYC_19829295_ChIP-Seq_ESCs_Human0.98407654
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97903548
67BCL6_27268052_Chip-Seq_Bcells_Human0.97734459
68WDR5_24793694_ChIP-Seq_LNCAP_Human0.96811734
69GATA1_26923725_Chip-Seq_HPCs_Mouse0.96321787
70KDM2B_26808549_Chip-Seq_REH_Human0.96164988
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96005598
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94985164
73LXR_22292898_ChIP-Seq_THP-1_Human0.94533528
74SMAD3_21741376_ChIP-Seq_EPCs_Human0.93829187
75PHF8_20622854_ChIP-Seq_HELA_Human0.93760119
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93268058
77PRDM14_20953172_ChIP-Seq_ESCs_Human0.93232471
78SMC4_20622854_ChIP-Seq_HELA_Human0.93122816
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93055392
80BCOR_27268052_Chip-Seq_Bcells_Human0.92980339
81HNFA_21074721_ChIP-Seq_CACO-2_Human0.92297730
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.92245321
83TBL1_22424771_ChIP-Seq_293T_Human0.92030501
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91848387
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91445879
86CBP_20019798_ChIP-Seq_JUKART_Human0.91445879
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.91354201
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91038791
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.90651030
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90127137
91RARB_27405468_Chip-Seq_BRAIN_Mouse0.89795216
92CTCF_20526341_ChIP-Seq_ESCs_Human0.89062840
93ERA_21632823_ChIP-Seq_H3396_Human0.88707641
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88558312
95AR_19668381_ChIP-Seq_PC3_Human0.88076040
96RBPJ_21746931_ChIP-Seq_IB4_Human0.87185655
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86554933
98SMAD4_21799915_ChIP-Seq_A2780_Human0.86041070
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.85586260
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85525506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous4.53568591
2MP0003283_abnormal_digestive_organ4.17115189
3MP0001501_abnormal_sleep_pattern3.73676754
4MP0003646_muscle_fatigue3.04824527
5MP0000678_abnormal_parathyroid_gland2.90227963
6MP0003878_abnormal_ear_physiology2.71921246
7MP0005377_hearing/vestibular/ear_phenot2.71921246
8MP0004145_abnormal_muscle_electrophysio2.24931508
9MP0005410_abnormal_fertilization2.24587828
10MP0001440_abnormal_grooming_behavior2.22650598
11MP0001905_abnormal_dopamine_level2.21547245
12MP0002249_abnormal_larynx_morphology2.19918482
13MP0002735_abnormal_chemical_nociception2.18050683
14MP0005423_abnormal_somatic_nervous2.16263083
15MP0002733_abnormal_thermal_nociception2.15245344
16MP0005645_abnormal_hypothalamus_physiol2.10229581
17MP0005083_abnormal_biliary_tract2.05105569
18MP0003879_abnormal_hair_cell2.03379744
19MP0002822_catalepsy2.03155832
20MP0009745_abnormal_behavioral_response2.00124498
21MP0003195_calcinosis1.92481824
22MP0001984_abnormal_olfaction1.85220707
23MP0001970_abnormal_pain_threshold1.83414680
24MP0005646_abnormal_pituitary_gland1.79124488
25MP0003635_abnormal_synaptic_transmissio1.77097475
26MP0004142_abnormal_muscle_tone1.75239345
27MP0008995_early_reproductive_senescence1.73191699
28MP0002557_abnormal_social/conspecific_i1.73149277
29MP0009046_muscle_twitch1.69690923
30MP0002572_abnormal_emotion/affect_behav1.66532693
31MP0009278_abnormal_bone_marrow1.52656378
32MP0002184_abnormal_innervation1.51397210
33MP0002734_abnormal_mechanical_nocicepti1.49105848
34MP0001765_abnormal_ion_homeostasis1.46120204
35MP0002638_abnormal_pupillary_reflex1.45670366
36MP0002063_abnormal_learning/memory/cond1.44114721
37MP0001963_abnormal_hearing_physiology1.43717983
38MP0000026_abnormal_inner_ear1.41161273
39MP0008872_abnormal_physiological_respon1.41157344
40MP0004885_abnormal_endolymph1.40993467
41MP0002009_preneoplasia1.39816145
42MP0004859_abnormal_synaptic_plasticity1.36070115
43MP0003942_abnormal_urinary_system1.30983991
44MP0001486_abnormal_startle_reflex1.27734620
45MP0003880_abnormal_central_pattern1.27139359
46MP0003698_abnormal_male_reproductive1.27041341
47MP0002067_abnormal_sensory_capabilities1.25532179
48MP0010386_abnormal_urinary_bladder1.21209273
49MP0004133_heterotaxia1.20520981
50MP0000955_abnormal_spinal_cord1.19689412
51MP0001879_abnormal_lymphatic_vessel1.18767708
52MP0005448_abnormal_energy_balance1.18607464
53MP0000372_irregular_coat_pigmentation1.16296473
54MP0002272_abnormal_nervous_system1.14694646
55MP0002653_abnormal_ependyma_morphology1.11114701
56MP0001485_abnormal_pinna_reflex1.09459933
57MP0003953_abnormal_hormone_level1.07571044
58MP0002064_seizures1.06693305
59MP0002089_abnormal_postnatal_growth/wei1.06199246
60MP0001929_abnormal_gametogenesis1.05728487
61MP0005451_abnormal_body_composition1.04542629
62MP0008569_lethality_at_weaning1.04065859
63MP0004233_abnormal_muscle_weight1.03984977
64MP0010329_abnormal_lipoprotein_level1.03108713
65MP0003137_abnormal_impulse_conducting1.02497578
66MP0002909_abnormal_adrenal_gland1.02236302
67MP0004043_abnormal_pH_regulation1.00279424
68MP0001348_abnormal_lacrimal_gland0.98407653
69MP0000230_abnormal_systemic_arterial0.97415586
70MP0002210_abnormal_sex_determination0.96994261
71MP0000631_abnormal_neuroendocrine_gland0.96331018
72MP0000534_abnormal_ureter_morphology0.95160858
73MP0002166_altered_tumor_susceptibility0.93832255
74MP0005220_abnormal_exocrine_pancreas0.93702958
75MP0001727_abnormal_embryo_implantation0.93655500
76MP0008770_decreased_survivor_rate0.93212546
77MP0000639_abnormal_adrenal_gland0.90842310
78MP0002928_abnormal_bile_duct0.89166996
79MP0005636_abnormal_mineral_homeostasis0.88781134
80MP0002752_abnormal_somatic_nervous0.87167682
81MP0005551_abnormal_eye_electrophysiolog0.85840205
82MP0001944_abnormal_pancreas_morphology0.84630503
83MP0001968_abnormal_touch/_nociception0.83292159
84MP0002229_neurodegeneration0.80845055
85MP0001986_abnormal_taste_sensitivity0.80797612
86MP0002933_joint_inflammation0.80652053
87MP0004147_increased_porphyrin_level0.80067185
88MP0000653_abnormal_sex_gland0.79599962
89MP0003119_abnormal_digestive_system0.78471498
90MP0005647_abnormal_sex_gland0.78180951
91MP0010368_abnormal_lymphatic_system0.78177049
92MP0008961_abnormal_basal_metabolism0.76382428
93MP0004085_abnormal_heartbeat0.76123099
94MP0004130_abnormal_muscle_cell0.75519603
95MP0002161_abnormal_fertility/fecundity0.74814431
96MP0002876_abnormal_thyroid_physiology0.74580138
97MP0002693_abnormal_pancreas_physiology0.74472003
98MP0001145_abnormal_male_reproductive0.72326264
99MP0001919_abnormal_reproductive_system0.68184017
100MP0002882_abnormal_neuron_morphology0.65894613

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)8.52153924
2Retinal dysplasia (HP:0007973)8.46965185
3Progressive cerebellar ataxia (HP:0002073)6.14053352
4Dysmetric saccades (HP:0000641)5.34497991
5Type II lissencephaly (HP:0007260)4.84218566
6Neonatal respiratory distress (HP:0002643)4.65324200
7Abnormality of binocular vision (HP:0011514)3.93347871
8Diplopia (HP:0000651)3.93347871
9Impaired smooth pursuit (HP:0007772)3.81318475
10Fetal akinesia sequence (HP:0001989)3.72694376
11Gaze-evoked nystagmus (HP:0000640)3.53499668
12Oral leukoplakia (HP:0002745)3.51960780
13Abnormality of the diencephalon (HP:0010662)3.36756824
14Truncal ataxia (HP:0002078)3.16327335
15Dysautonomia (HP:0002459)3.14210655
16Abnormality of the fingertips (HP:0001211)3.08811544
17Narrow nasal bridge (HP:0000446)3.07746119
18Aplastic anemia (HP:0001915)3.06675930
19Hypoplasia of the iris (HP:0007676)2.98293070
20Autoimmune thrombocytopenia (HP:0001973)2.97940669
21Lip pit (HP:0100267)2.95685986
22Urinary bladder sphincter dysfunction (HP:0002839)2.90239625
23Abnormality of the labia majora (HP:0012881)2.87651547
24Abnormality of the vitreous humor (HP:0004327)2.83517225
25Rib fusion (HP:0000902)2.80472320
26Depressed nasal tip (HP:0000437)2.71460525
27Long clavicles (HP:0000890)2.67334345
28Popliteal pterygium (HP:0009756)2.61359180
29Congenital stationary night blindness (HP:0007642)2.58132826
30Febrile seizures (HP:0002373)2.56991033
31Homocystinuria (HP:0002156)2.54645523
32Abnormality of homocysteine metabolism (HP:0010919)2.54645523
33Urethral obstruction (HP:0000796)2.54406790
34Aplasia of the musculature (HP:0100854)2.54048456
35Intellectual disability, progressive (HP:0006887)2.53341150
36Hypoproteinemia (HP:0003075)2.48105324
37Abnormality of ocular smooth pursuit (HP:0000617)2.47013602
38Mesangial abnormality (HP:0001966)2.45235651
39Congenital sensorineural hearing impairment (HP:0008527)2.43089544
40Abnormality of cochlea (HP:0000375)2.42122057
41Abnormal pancreas size (HP:0012094)2.41827705
42Cholecystitis (HP:0001082)2.41410340
43Abnormal gallbladder physiology (HP:0012438)2.41410340
44Akinesia (HP:0002304)2.36326830
45Morphological abnormality of the inner ear (HP:0011390)2.35503643
46Hemiparesis (HP:0001269)2.33250786
47Retinal detachment (HP:0000541)2.31638180
48Self-mutilation (HP:0000742)2.30308573
49Protruding tongue (HP:0010808)2.29836274
50Downturned corners of mouth (HP:0002714)2.27290574
51Hypoalbuminemia (HP:0003073)2.23373214
52Abnormal albumin level (HP:0012116)2.23373214
53Venous insufficiency (HP:0005293)2.22906514
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21948827
55Facial shape deformation (HP:0011334)2.20783355
56Potter facies (HP:0002009)2.20783355
57Decreased central vision (HP:0007663)2.20206062
58Morphological abnormality of the middle ear (HP:0008609)2.19821540
59Spinal muscular atrophy (HP:0007269)2.19666810
60Ectopic kidney (HP:0000086)2.16239684
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15906120
62Short 5th finger (HP:0009237)2.15134753
63Hypergonadotropic hypogonadism (HP:0000815)2.14795676
64Hypoplasia of the pons (HP:0012110)2.14012487
65Attenuation of retinal blood vessels (HP:0007843)2.13554051
66Abnormality of macular pigmentation (HP:0008002)2.12889117
67Bicornuate uterus (HP:0000813)2.12396269
68Abnormality of the columella (HP:0009929)2.12264160
69Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10726754
70Areflexia of lower limbs (HP:0002522)2.09364573
71Postural instability (HP:0002172)2.08329759
72Poikiloderma (HP:0001029)2.07632671
73Abnormality of the pupil (HP:0000615)2.06885262
74Abnormality of saccadic eye movements (HP:0000570)2.04740386
75Stereotypic behavior (HP:0000733)2.01635731
76Hypoplastic nipples (HP:0002557)2.01231599
77Amniotic constriction ring (HP:0009775)2.00033482
78Abnormality of placental membranes (HP:0011409)2.00033482
79Symphalangism affecting the phalanges of the hand (HP:0009773)1.98410981
80Renovascular hypertension (HP:0100817)1.94926733
81Rough bone trabeculation (HP:0100670)1.93479296
82Sparse lateral eyebrow (HP:0005338)1.92627757
83Truncal obesity (HP:0001956)1.91970968
84Tubular atrophy (HP:0000092)1.90235978
85Epileptic encephalopathy (HP:0200134)1.89693892
86Chronic hepatic failure (HP:0100626)1.88979971
87Sclerocornea (HP:0000647)1.87085845
88Hypoplastic ischia (HP:0003175)1.86715142
89Constricted visual fields (HP:0001133)1.82917287
90Proximal tubulopathy (HP:0000114)1.82522615
91Hyperthyroidism (HP:0000836)1.82327250
92Severe combined immunodeficiency (HP:0004430)1.80989944
93Abnormality of the pons (HP:0007361)1.80594901
94Decreased circulating renin level (HP:0003351)1.79046788
95Hypertensive crisis (HP:0100735)1.74817474
96IgG deficiency (HP:0004315)1.73953419
97Absence seizures (HP:0002121)1.73161825
98Megalocornea (HP:0000485)1.71808106
99Large for gestational age (HP:0001520)1.71503716
100Slow saccadic eye movements (HP:0000514)1.71487484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.94241851
2TAOK14.83604155
3INSRR4.41334966
4SIK23.95134889
5RIPK43.51835387
6PASK3.31553267
7ICK3.18884907
8NTRK32.73016846
9MAP3K72.27208774
10PLK41.93124974
11MAP3K41.84828137
12MAP2K71.73911650
13CDK121.66953090
14TNIK1.66853345
15MARK31.54148322
16DAPK21.52468807
17ZAP701.42837577
18TAOK21.42250912
19BMX1.42132689
20MAPK151.41805153
21BMPR21.41225809
22CAMKK11.39639264
23CDK41.33253766
24TRIB31.33000385
25TYRO31.31445906
26SIK31.16882406
27STK161.16254754
28MAPKAPK31.15431024
29BRD41.06289476
30MATK1.03372246
31PRKAA11.02815331
32NEK21.02269802
33TAOK30.89733118
34CAMKK20.89039695
35TRPM70.88364016
36NME10.87715761
37PIM10.87031748
38PIK3CG0.84905936
39DDR20.84858746
40PRKCE0.84455214
41TEC0.82576237
42WNK40.80814582
43MTOR0.80148476
44MAP3K110.77632754
45WNK10.77258052
46CAMK1D0.71937108
47PKN10.71696963
48PNCK0.70714690
49PIM20.68663368
50KIT0.67290275
51CAMK1G0.66630227
52MAPKAPK20.66380023
53BTK0.65988209
54SCYL20.65031906
55MAP3K10.64654559
56TNK20.64252990
57ERBB20.63212846
58PTK2B0.62900025
59SIK10.62783805
60MAP4K10.61128215
61STK110.60769132
62ACVR1B0.58717684
63PRKCH0.58348178
64BMPR1B0.57781936
65CLK10.55802580
66DAPK10.55091006
67PRKAA20.51698582
68EGFR0.50363668
69NLK0.49996404
70MAP3K100.48947031
71PRKD20.48866713
72RPS6KA30.48792806
73SYK0.48282703
74ITK0.46680356
75NEK60.45648527
76RPS6KA60.44016983
77KDR0.43939383
78ADRBK20.41328888
79MAPK130.40393466
80WNK30.39824263
81MAPK110.39477788
82GSK3B0.38563512
83SGK10.38144818
84CDC42BPA0.38142195
85ADRBK10.37463341
86CSNK1A10.37168131
87CDC70.36818587
88PRKCA0.35787614
89BRSK20.34951450
90MAPK90.33975597
91EEF2K0.33568645
92MARK20.33354035
93PRKG10.31366650
94PHKG10.30899312
95PHKG20.30899312
96PRKCG0.30881814
97CHEK20.30850794
98LCK0.29990632
99MARK10.29858852
100MAP2K60.29779877

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.67579429
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.87272195
3Taste transduction_Homo sapiens_hsa047423.19371286
4Morphine addiction_Homo sapiens_hsa050323.17212074
5GABAergic synapse_Homo sapiens_hsa047273.03642260
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.94195224
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70815052
8Type II diabetes mellitus_Homo sapiens_hsa049302.52870994
9Insulin secretion_Homo sapiens_hsa049112.19226554
10Butanoate metabolism_Homo sapiens_hsa006502.06515040
11Serotonergic synapse_Homo sapiens_hsa047261.94332787
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91606214
13Lysine degradation_Homo sapiens_hsa003101.84440323
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81714311
15Circadian entrainment_Homo sapiens_hsa047131.64995741
16Primary immunodeficiency_Homo sapiens_hsa053401.64992203
17Olfactory transduction_Homo sapiens_hsa047401.54252978
18mTOR signaling pathway_Homo sapiens_hsa041501.38029101
19Cholinergic synapse_Homo sapiens_hsa047251.37599224
20One carbon pool by folate_Homo sapiens_hsa006701.37080768
21Selenocompound metabolism_Homo sapiens_hsa004501.36132833
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32506531
23Glutamatergic synapse_Homo sapiens_hsa047241.32210824
24Dopaminergic synapse_Homo sapiens_hsa047281.24878307
25Calcium signaling pathway_Homo sapiens_hsa040201.23729780
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.20566980
27Synaptic vesicle cycle_Homo sapiens_hsa047211.20159812
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19086057
29Ether lipid metabolism_Homo sapiens_hsa005651.13961457
30ABC transporters_Homo sapiens_hsa020101.12013001
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10059479
32Sulfur relay system_Homo sapiens_hsa041221.08196369
33Regulation of autophagy_Homo sapiens_hsa041401.02716277
34Circadian rhythm_Homo sapiens_hsa047101.02162139
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.00621958
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95031073
37Linoleic acid metabolism_Homo sapiens_hsa005910.93504683
38Phototransduction_Homo sapiens_hsa047440.90205311
39Gastric acid secretion_Homo sapiens_hsa049710.85334320
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85156752
41Oxytocin signaling pathway_Homo sapiens_hsa049210.84446744
42mRNA surveillance pathway_Homo sapiens_hsa030150.84269430
43Folate biosynthesis_Homo sapiens_hsa007900.83107749
44Ras signaling pathway_Homo sapiens_hsa040140.82996711
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.82497438
46Tryptophan metabolism_Homo sapiens_hsa003800.80764521
47Renin secretion_Homo sapiens_hsa049240.80467065
48AMPK signaling pathway_Homo sapiens_hsa041520.79894954
49Insulin resistance_Homo sapiens_hsa049310.79747737
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78760318
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77925179
52VEGF signaling pathway_Homo sapiens_hsa043700.74801704
53Homologous recombination_Homo sapiens_hsa034400.74263020
54Cocaine addiction_Homo sapiens_hsa050300.73027780
55Ovarian steroidogenesis_Homo sapiens_hsa049130.72524535
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.72332294
57Type I diabetes mellitus_Homo sapiens_hsa049400.71857556
58T cell receptor signaling pathway_Homo sapiens_hsa046600.71043179
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68724910
60Hedgehog signaling pathway_Homo sapiens_hsa043400.68213191
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.67901907
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65930903
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63625525
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62984230
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62141516
66Salivary secretion_Homo sapiens_hsa049700.58955725
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58876844
68Mismatch repair_Homo sapiens_hsa034300.58813584
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57729722
70Nitrogen metabolism_Homo sapiens_hsa009100.57667672
71Chemical carcinogenesis_Homo sapiens_hsa052040.53740409
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53529756
73Non-small cell lung cancer_Homo sapiens_hsa052230.53463475
74Retinol metabolism_Homo sapiens_hsa008300.53408705
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53224577
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51168212
77Amphetamine addiction_Homo sapiens_hsa050310.48629202
78HIF-1 signaling pathway_Homo sapiens_hsa040660.48343327
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47903206
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.46419759
81Fructose and mannose metabolism_Homo sapiens_hsa000510.43051407
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42866157
83Choline metabolism in cancer_Homo sapiens_hsa052310.42734793
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39460207
85beta-Alanine metabolism_Homo sapiens_hsa004100.38492524
86Dorso-ventral axis formation_Homo sapiens_hsa043200.37605101
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32910366
88Wnt signaling pathway_Homo sapiens_hsa043100.31654066
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30519105
90Herpes simplex infection_Homo sapiens_hsa051680.30456834
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29746228
92cAMP signaling pathway_Homo sapiens_hsa040240.29166834
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28688856
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27391635
95Measles_Homo sapiens_hsa051620.27302922
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.26465305
97Estrogen signaling pathway_Homo sapiens_hsa049150.25673486
98Inositol phosphate metabolism_Homo sapiens_hsa005620.25340768
99Renin-angiotensin system_Homo sapiens_hsa046140.25178451
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24420256

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