FAM27E3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.34254324
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.33609841
3negative regulation of translation, ncRNA-mediated (GO:0040033)5.33609841
4regulation of translation, ncRNA-mediated (GO:0045974)5.33609841
5pre-miRNA processing (GO:0031054)4.92903758
6mRNA cleavage (GO:0006379)4.90665009
7response to pheromone (GO:0019236)4.62696785
8cilium or flagellum-dependent cell motility (GO:0001539)4.36772970
9response to misfolded protein (GO:0051788)4.28931173
10regulation of female gonad development (GO:2000194)4.24432652
11microtubule depolymerization (GO:0007019)4.09592380
12sperm motility (GO:0030317)4.08869103
13acrosome reaction (GO:0007340)3.92437043
14chromosome condensation (GO:0030261)3.90992511
15DNA packaging (GO:0006323)3.82432881
16endothelial cell chemotaxis (GO:0035767)3.74333840
17positive regulation of CREB transcription factor activity (GO:0032793)3.74248167
18motile cilium assembly (GO:0044458)3.68478445
19chromatin silencing (GO:0006342)3.67986765
20misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.61534202
21cellular ketone body metabolic process (GO:0046950)3.61469023
22microtubule polymerization or depolymerization (GO:0031109)3.53304362
23regulation of sarcomere organization (GO:0060297)3.50704688
24cranial nerve morphogenesis (GO:0021602)3.45834619
25protein retention in ER lumen (GO:0006621)3.44926164
26peptidyl-threonine dephosphorylation (GO:0035970)3.40996377
27chemosensory behavior (GO:0007635)3.39163118
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33661945
29axonemal dynein complex assembly (GO:0070286)3.32309671
30DNA replication checkpoint (GO:0000076)3.28982806
31snRNA processing (GO:0016180)3.25905807
32neural tube development (GO:0021915)3.22062937
33ketone body metabolic process (GO:1902224)3.17060459
34snRNA metabolic process (GO:0016073)3.14084707
35positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.09482878
36regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.09482878
37glucocorticoid receptor signaling pathway (GO:0042921)3.09407370
38behavioral response to nicotine (GO:0035095)3.07373662
39DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.03803487
40histone lysine methylation (GO:0034968)3.03514461
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02173937
42phosphorelay signal transduction system (GO:0000160)3.01174592
43regulation of centriole replication (GO:0046599)3.00278281
44negative regulation of gene expression, epigenetic (GO:0045814)2.98733420
45cilium movement (GO:0003341)2.98715111
46positive regulation of synapse maturation (GO:0090129)2.97654937
47NAD biosynthetic process (GO:0009435)2.97148266
48histone H3-K9 methylation (GO:0051567)2.97035002
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95965440
50musculoskeletal movement (GO:0050881)2.93415962
51multicellular organismal movement (GO:0050879)2.93415962
52regulation of histone H3-K4 methylation (GO:0051569)2.93125820
53centriole replication (GO:0007099)2.92879078
54peptidyl-lysine dimethylation (GO:0018027)2.91050247
55microtubule severing (GO:0051013)2.90802940
56coenzyme catabolic process (GO:0009109)2.89527453
57spermatid nucleus differentiation (GO:0007289)2.88166424
58gene silencing (GO:0016458)2.87716600
59membrane depolarization during action potential (GO:0086010)2.85867542
60protein K48-linked deubiquitination (GO:0071108)2.84402093
61protein polyglutamylation (GO:0018095)2.83826497
62histone H3-K4 methylation (GO:0051568)2.83463793
63ventricular system development (GO:0021591)2.83027747
64sensory perception of smell (GO:0007608)2.81224192
65positive regulation of gene expression, epigenetic (GO:0045815)2.81172809
66sperm-egg recognition (GO:0035036)2.79437314
67interkinetic nuclear migration (GO:0022027)2.75516232
68negative regulation of histone methylation (GO:0031061)2.75302542
69snRNA transcription (GO:0009301)2.73379500
70calcium ion-dependent exocytosis (GO:0017156)2.72988470
71DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72835587
72prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.71685819
73centriole assembly (GO:0098534)2.71635501
74regulation of ARF GTPase activity (GO:0032312)2.69913908
75histone H3-K9 modification (GO:0061647)2.68028638
76regulation of cilium movement (GO:0003352)2.67322612
77meiotic chromosome segregation (GO:0045132)2.66898530
78histone methylation (GO:0016571)2.64195087
79regulation of somitogenesis (GO:0014807)2.63886332
80nuclear pore complex assembly (GO:0051292)2.60818304
81negative regulation of translational initiation (GO:0045947)2.60427266
82spermatid development (GO:0007286)2.58352821
83fusion of sperm to egg plasma membrane (GO:0007342)2.56873964
84corticosteroid receptor signaling pathway (GO:0031958)2.56848572
85regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.56360047
86positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.56360047
87histone H3-K9 demethylation (GO:0033169)2.55101913
88DNA replication initiation (GO:0006270)2.54108921
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.54056599
90regulation of centrosome cycle (GO:0046605)2.53171505
91axoneme assembly (GO:0035082)2.53070158
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51861416
93regulation of centrosome duplication (GO:0010824)2.51354699
94peristalsis (GO:0030432)2.49835890
95binding of sperm to zona pellucida (GO:0007339)2.49735023
96epithelial cilium movement (GO:0003351)2.49711551
97sperm capacitation (GO:0048240)2.49221257
98regulation of glutamate receptor signaling pathway (GO:1900449)2.47571643
99protein localization to synapse (GO:0035418)2.45021778
100protein-DNA complex disassembly (GO:0032986)2.44368577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.22584714
2E2F7_22180533_ChIP-Seq_HELA_Human3.81725459
3DROSHA_22980978_ChIP-Seq_HELA_Human3.28924958
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.08823576
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72394239
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42886463
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35563694
8VDR_22108803_ChIP-Seq_LS180_Human2.08510857
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05087311
10AR_21572438_ChIP-Seq_LNCaP_Human2.04724543
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.02987917
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97650325
13FOXM1_23109430_ChIP-Seq_U2OS_Human1.94828117
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.92120498
15REST_21632747_ChIP-Seq_MESCs_Mouse1.79777794
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69672074
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69672074
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.68229073
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62287301
20P68_20966046_ChIP-Seq_HELA_Human1.62053966
21SMC4_20622854_ChIP-Seq_HELA_Human1.61642075
22CTCF_27219007_Chip-Seq_Bcells_Human1.60621425
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.59812977
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57134636
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56573537
26LXR_22292898_ChIP-Seq_THP-1_Human1.55254908
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54608656
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.54219981
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.48210036
30E2F1_20622854_ChIP-Seq_HELA_Human1.47543812
31ZNF274_21170338_ChIP-Seq_K562_Hela1.46406453
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43595685
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42476849
34E2F1_17053090_ChIP-ChIP_MCF-7_Human1.41387026
35PHF8_20622854_ChIP-Seq_HELA_Human1.40931258
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40752274
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.38687926
38OCT4_20526341_ChIP-Seq_ESCs_Human1.38647767
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38267947
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.37618685
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35583419
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33383099
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30718051
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27933597
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27933597
46ERA_21632823_ChIP-Seq_H3396_Human1.27471982
47RNF2_27304074_Chip-Seq_NSC_Mouse1.26380865
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26296779
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.25382898
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25117137
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25012056
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24987576
53KDM5A_27292631_Chip-Seq_BREAST_Human1.23223261
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21520774
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21303919
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.19970752
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.17710202
58OCT4_19829295_ChIP-Seq_ESCs_Human1.15523283
59MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13522576
60BCL6_27268052_Chip-Seq_Bcells_Human1.13503994
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.13076521
62CREB1_26743006_Chip-Seq_LNCaP_Human1.13057825
63TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12369554
64BCOR_27268052_Chip-Seq_Bcells_Human1.11881590
65CTCF_20526341_ChIP-Seq_ESCs_Human1.10051220
66STAT3_23295773_ChIP-Seq_U87_Human1.09339399
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.09178256
68KDM2B_26808549_Chip-Seq_K562_Human1.04953937
69P53_21459846_ChIP-Seq_SAOS-2_Human1.04729710
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04698174
71TP63_22573176_ChIP-Seq_HFKS_Human1.04454054
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04188941
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03473230
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03447170
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.03386320
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99662377
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99386313
78NFYB_21822215_ChIP-Seq_K562_Human0.99316382
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99182776
80AR_19668381_ChIP-Seq_PC3_Human0.98531877
81RING1B_27294783_Chip-Seq_NPCs_Mouse0.97531020
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96769261
83MYC_22102868_ChIP-Seq_BL_Human0.96752228
84SA1_27219007_Chip-Seq_Bcells_Human0.96539366
85RAC3_21632823_ChIP-Seq_H3396_Human0.96204978
86TP53_20018659_ChIP-ChIP_R1E_Mouse0.96105855
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95790244
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95767810
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92841385
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92129025
91TCF4_23295773_ChIP-Seq_U87_Human0.91836883
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91266275
93TBL1_22424771_ChIP-Seq_293T_Human0.90498545
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89900842
95TAF2_19829295_ChIP-Seq_ESCs_Human0.88620701
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87569313
97NFYA_21822215_ChIP-Seq_K562_Human0.86877091
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85595325
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85505402
100P300_27268052_Chip-Seq_Bcells_Human0.85160389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland3.02980781
2MP0002249_abnormal_larynx_morphology2.89866245
3MP0003878_abnormal_ear_physiology2.89372358
4MP0005377_hearing/vestibular/ear_phenot2.89372358
5MP0005410_abnormal_fertilization2.85433081
6MP0005670_abnormal_white_adipose2.60054799
7MP0006276_abnormal_autonomic_nervous2.44556844
8MP0001501_abnormal_sleep_pattern2.40508451
9MP0009046_muscle_twitch2.08427785
10MP0002735_abnormal_chemical_nociception2.04863287
11MP0003698_abnormal_male_reproductive2.02418129
12MP0008057_abnormal_DNA_replication1.99806076
13MP0009745_abnormal_behavioral_response1.95143885
14MP0010094_abnormal_chromosome_stability1.93269779
15MP0001348_abnormal_lacrimal_gland1.92526609
16MP0002822_catalepsy1.85305557
17MP0002733_abnormal_thermal_nociception1.85282447
18MP0001929_abnormal_gametogenesis1.85144615
19MP0004859_abnormal_synaptic_plasticity1.84464164
20MP0005645_abnormal_hypothalamus_physiol1.79902311
21MP0003879_abnormal_hair_cell1.76694597
22MP0004233_abnormal_muscle_weight1.72810453
23MP0001970_abnormal_pain_threshold1.61246087
24MP0001905_abnormal_dopamine_level1.58423277
25MP0008058_abnormal_DNA_repair1.57119973
26MP0002557_abnormal_social/conspecific_i1.55806247
27MP0003635_abnormal_synaptic_transmissio1.55569730
28MP0003646_muscle_fatigue1.53598773
29MP0002572_abnormal_emotion/affect_behav1.50607378
30MP0003111_abnormal_nucleus_morphology1.49806074
31MP0005423_abnormal_somatic_nervous1.49173825
32MP0001440_abnormal_grooming_behavior1.49135421
33MP0002638_abnormal_pupillary_reflex1.48738142
34MP0008995_early_reproductive_senescence1.47503734
35MP0002734_abnormal_mechanical_nocicepti1.40068306
36MP0002938_white_spotting1.39136580
37MP0003077_abnormal_cell_cycle1.36975774
38MP0000955_abnormal_spinal_cord1.36653435
39MP0002067_abnormal_sensory_capabilities1.35350380
40MP0001486_abnormal_startle_reflex1.34818858
41MP0005551_abnormal_eye_electrophysiolog1.33314951
42MP0002063_abnormal_learning/memory/cond1.33289203
43MP0004142_abnormal_muscle_tone1.32978523
44MP0003942_abnormal_urinary_system1.32516433
45MP0001485_abnormal_pinna_reflex1.32501411
46MP0002210_abnormal_sex_determination1.26485934
47MP0000026_abnormal_inner_ear1.26360315
48MP0003136_yellow_coat_color1.24641264
49MP0001968_abnormal_touch/_nociception1.22764839
50MP0004885_abnormal_endolymph1.22636076
51MP0002272_abnormal_nervous_system1.22183037
52MP0000681_abnormal_thyroid_gland1.17915019
53MP0000569_abnormal_digit_pigmentation1.17807558
54MP0002161_abnormal_fertility/fecundity1.16938003
55MP0000631_abnormal_neuroendocrine_gland1.16898990
56MP0004145_abnormal_muscle_electrophysio1.15928641
57MP0006292_abnormal_olfactory_placode1.14224527
58MP0005646_abnormal_pituitary_gland1.14128159
59MP0001963_abnormal_hearing_physiology1.09561806
60MP0004043_abnormal_pH_regulation1.08653809
61MP0000778_abnormal_nervous_system1.08344627
62MP0003861_abnormal_nervous_system1.07598158
63MP0001188_hyperpigmentation1.06932824
64MP0003283_abnormal_digestive_organ1.05787724
65MP0002229_neurodegeneration1.04769656
66MP0002184_abnormal_innervation1.04212420
67MP0000653_abnormal_sex_gland1.03224949
68MP0001145_abnormal_male_reproductive1.02391116
69MP0002752_abnormal_somatic_nervous1.02125575
70MP0002064_seizures1.01537149
71MP0009278_abnormal_bone_marrow1.00166307
72MP0002882_abnormal_neuron_morphology1.00136868
73MP0005174_abnormal_tail_pigmentation0.95858665
74MP0002928_abnormal_bile_duct0.94361886
75MP0001765_abnormal_ion_homeostasis0.93134126
76MP0003693_abnormal_embryo_hatching0.92734384
77MP0008770_decreased_survivor_rate0.91757657
78MP0008569_lethality_at_weaning0.90638885
79MP0005220_abnormal_exocrine_pancreas0.89894125
80MP0003119_abnormal_digestive_system0.87683915
81MP0003937_abnormal_limbs/digits/tail_de0.87581725
82MP0002152_abnormal_brain_morphology0.87427288
83MP0003385_abnormal_body_wall0.87189559
84MP0003045_fibrosis0.85882058
85MP0004147_increased_porphyrin_level0.84939926
86MP0002653_abnormal_ependyma_morphology0.84155063
87MP0003718_maternal_effect0.83413225
88MP0003705_abnormal_hypodermis_morpholog0.83129560
89MP0001944_abnormal_pancreas_morphology0.79638433
90MP0003632_abnormal_nervous_system0.79317002
91MP0003786_premature_aging0.78775670
92MP0008872_abnormal_physiological_respon0.78439280
93MP0006072_abnormal_retinal_apoptosis0.77359381
94MP0005076_abnormal_cell_differentiation0.76677557
95MP0005195_abnormal_posterior_eye0.76033070
96MP0004742_abnormal_vestibular_system0.75477118
97MP0005171_absent_coat_pigmentation0.73351816
98MP0004811_abnormal_neuron_physiology0.72255075
99MP0009053_abnormal_anal_canal0.71492496
100MP0008961_abnormal_basal_metabolism0.71318504

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)6.84557789
2Dysmetric saccades (HP:0000641)5.27721087
3Progressive cerebellar ataxia (HP:0002073)4.66533655
4Retinal dysplasia (HP:0007973)4.41400437
5Gaze-evoked nystagmus (HP:0000640)4.00085533
6Impaired smooth pursuit (HP:0007772)3.50863272
7Abnormality of the aortic arch (HP:0012303)3.50061701
8Abnormality of the diencephalon (HP:0010662)3.30463077
9Urethral obstruction (HP:0000796)3.26550041
10Abnormality of binocular vision (HP:0011514)3.17276919
11Diplopia (HP:0000651)3.17276919
12Abnormality of the fingertips (HP:0001211)3.07305893
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03918570
14Ectopic kidney (HP:0000086)3.02016257
15Sclerocornea (HP:0000647)2.83580377
16Severe visual impairment (HP:0001141)2.82594934
17Chromsome breakage (HP:0040012)2.82540374
18Absent/shortened dynein arms (HP:0200106)2.81917916
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.81917916
20Duplicated collecting system (HP:0000081)2.80077731
21Hypoplasia of the pons (HP:0012110)2.74000325
22Lip pit (HP:0100267)2.67030255
23Abnormal ciliary motility (HP:0012262)2.65998749
24Abnormality of the renal collecting system (HP:0004742)2.59731476
25Intestinal fistula (HP:0100819)2.56592484
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54081146
27Hyperthyroidism (HP:0000836)2.52663723
28Abnormality of the pons (HP:0007361)2.48658544
29Hypoplasia of the iris (HP:0007676)2.43377467
30Abnormality of ocular smooth pursuit (HP:0000617)2.40792683
31Abnormality of DNA repair (HP:0003254)2.40325780
32Dysautonomia (HP:0002459)2.37880400
33Abnormality of cochlea (HP:0000375)2.36569964
34Postural instability (HP:0002172)2.34065770
35Nephronophthisis (HP:0000090)2.32758713
36Bony spicule pigmentary retinopathy (HP:0007737)2.31357443
37Truncus arteriosus (HP:0001660)2.30562876
38Urinary bladder sphincter dysfunction (HP:0002839)2.30427216
39Oligodontia (HP:0000677)2.27680866
40Abnormal respiratory motile cilium physiology (HP:0012261)2.27375319
41Abnormal respiratory motile cilium morphology (HP:0005938)2.26477515
42Abnormal respiratory epithelium morphology (HP:0012253)2.26477515
43Birth length less than 3rd percentile (HP:0003561)2.25020835
44Morphological abnormality of the inner ear (HP:0011390)2.17752960
45Hypoplastic ischia (HP:0003175)2.17158184
46Cystic liver disease (HP:0006706)2.17140636
47Pancreatic fibrosis (HP:0100732)2.16663218
48Autoimmune thrombocytopenia (HP:0001973)2.16423097
49Truncal ataxia (HP:0002078)2.14597378
50Stereotypic behavior (HP:0000733)2.14159591
51Attenuation of retinal blood vessels (HP:0007843)2.14144439
52Renovascular hypertension (HP:0100817)2.12251374
53Sparse lateral eyebrow (HP:0005338)2.10070983
54Congenital stationary night blindness (HP:0007642)2.10045113
55Abnormality of homocysteine metabolism (HP:0010919)2.08768274
56Homocystinuria (HP:0002156)2.08768274
57Tubulointerstitial nephritis (HP:0001970)2.08595421
58Chronic hepatic failure (HP:0100626)2.04297619
59Poikiloderma (HP:0001029)2.03329470
60Bell-shaped thorax (HP:0001591)2.01900693
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99367337
62Obsessive-compulsive behavior (HP:0000722)1.97044669
63Narrow nasal bridge (HP:0000446)1.96072416
64Polycystic kidney dysplasia (HP:0000113)1.96049018
65Patellar aplasia (HP:0006443)1.94434188
66Abnormality of the renal medulla (HP:0100957)1.92833053
67True hermaphroditism (HP:0010459)1.91023875
68Pancreatic cysts (HP:0001737)1.88859291
69Polydipsia (HP:0001959)1.88427602
70Abnormal drinking behavior (HP:0030082)1.88427602
71Abnormality of the ischium (HP:0003174)1.87583369
72Atelectasis (HP:0100750)1.86660418
73Protruding tongue (HP:0010808)1.84435794
74Epileptic encephalopathy (HP:0200134)1.84147032
75Hyperventilation (HP:0002883)1.83977456
76Male infertility (HP:0003251)1.83264092
77Abnormality of the columella (HP:0009929)1.82587123
78Bowel incontinence (HP:0002607)1.81928482
79Impulsivity (HP:0100710)1.81913361
80Abnormality of the vitreous humor (HP:0004327)1.80430638
81Hyperacusis (HP:0010780)1.77768094
82Aplasia/Hypoplasia of the patella (HP:0006498)1.77466740
83Long eyelashes (HP:0000527)1.77091162
84Attention deficit hyperactivity disorder (HP:0007018)1.77081577
85Anal stenosis (HP:0002025)1.76503558
86Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76464394
87Rhinitis (HP:0012384)1.76117193
88Highly arched eyebrow (HP:0002553)1.76052107
89Self-mutilation (HP:0000742)1.75975774
90Febrile seizures (HP:0002373)1.74971162
91Decreased central vision (HP:0007663)1.74323932
92Truncal obesity (HP:0001956)1.69775254
93Broad-based gait (HP:0002136)1.69585517
94Prominent nose (HP:0000448)1.68312891
95Absent epiphyses (HP:0010577)1.67746514
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67746514
97Central scotoma (HP:0000603)1.67683437
98Abnormality of macular pigmentation (HP:0008002)1.67621308
99Trigonocephaly (HP:0000243)1.67380632
100Tubular atrophy (HP:0000092)1.66210552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.82420577
2FRK4.17128845
3CDK123.79170322
4TRIB33.60575427
5SIK23.50144462
6ICK3.12164463
7EEF2K2.93782120
8CDC72.72596118
9PLK42.62623725
10NTRK32.33847941
11CAMK1G2.26331250
12PNCK2.21774951
13CAMK1D1.98903168
14MAPK151.89700607
15NEK21.83345070
16BRD41.82916310
17TAOK31.79534957
18MTOR1.53921144
19ADRBK21.50169796
20PRKD31.40439912
21WNK11.37246552
22CHEK21.33892761
23DAPK21.32322799
24WNK41.28966374
25PRKAA11.25932680
26DDR21.25812398
27MAPK111.23531592
28ATR1.15530183
29MAP3K101.14918858
30TLK11.13040384
31MARK21.12711783
32TNK21.11667274
33BRSK21.04011308
34CDK41.03886603
35WEE11.02638373
36PASK1.02011564
37CAMKK11.01328126
38BRSK11.00907656
39MAPK130.98914322
40AKT30.91813631
41CHEK10.90381985
42PKN20.88895282
43PKN10.87462947
44MAP3K70.84364843
45STK160.84249703
46TYRO30.84105017
47TTK0.83044442
48PRKAA20.80952515
49NME10.79157931
50CDK20.77200711
51CDK10.76685021
52PLK10.75038447
53MAPKAPK50.73774367
54MST1R0.71779542
55PRKCH0.71750301
56NTRK20.71197883
57SMG10.70336214
58GSK3B0.69858794
59PRKCG0.67560258
60CDC42BPA0.67359032
61MAPKAPK30.67181952
62MAP3K40.61575181
63MAP4K20.61414304
64PTK2B0.60699311
65CASK0.59749994
66CDK70.58105999
67ATM0.57401341
68RPS6KB20.56530854
69PINK10.55654410
70CAMK10.55651709
71CSNK1E0.54740440
72ACVR1B0.54353693
73RPS6KA60.53188332
74SIK10.51825086
75AKT10.51588745
76CDK30.50273599
77SGK10.50236869
78BMPR1B0.49342120
79PDPK10.48228185
80MAP3K20.47357966
81MAPK140.46356858
82BMX0.44710353
83MAPK80.44604636
84CAMK40.42855288
85MARK10.42505102
86ERBB20.41576410
87MAPK100.40189931
88PRKCE0.40182480
89PDK10.40174330
90AURKA0.39796716
91EIF2AK10.39643118
92ADRBK10.37648136
93BTK0.37620552
94MAPK10.36995237
95RPS6KA30.34253557
96NUAK10.32656828
97RPS6KA10.31847872
98MAP2K60.31468994
99PRKDC0.31404984
100CSNK1A10.31376654

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.37962287
2Lysine degradation_Homo sapiens_hsa003102.94032849
3Taste transduction_Homo sapiens_hsa047422.89702463
4Homologous recombination_Homo sapiens_hsa034402.59674561
5Morphine addiction_Homo sapiens_hsa050322.48574196
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44466267
7Olfactory transduction_Homo sapiens_hsa047402.34289613
8Butanoate metabolism_Homo sapiens_hsa006502.28341594
9GABAergic synapse_Homo sapiens_hsa047272.13820464
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13802313
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.05872359
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05195467
13Fanconi anemia pathway_Homo sapiens_hsa034601.91766124
14Type II diabetes mellitus_Homo sapiens_hsa049301.80368838
15DNA replication_Homo sapiens_hsa030301.76175165
16Cholinergic synapse_Homo sapiens_hsa047251.70011603
17Glutamatergic synapse_Homo sapiens_hsa047241.52286938
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50455249
19Notch signaling pathway_Homo sapiens_hsa043301.47100772
20Circadian entrainment_Homo sapiens_hsa047131.44874722
21One carbon pool by folate_Homo sapiens_hsa006701.44191333
22Insulin secretion_Homo sapiens_hsa049111.42208193
23mRNA surveillance pathway_Homo sapiens_hsa030151.40082505
24Selenocompound metabolism_Homo sapiens_hsa004501.39402053
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31768876
26Serotonergic synapse_Homo sapiens_hsa047261.31312391
27RNA transport_Homo sapiens_hsa030131.24682765
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24401765
29ABC transporters_Homo sapiens_hsa020101.19654454
30Estrogen signaling pathway_Homo sapiens_hsa049151.16196224
31mTOR signaling pathway_Homo sapiens_hsa041501.15622936
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15586799
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.14787767
34Sulfur relay system_Homo sapiens_hsa041221.10284735
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09618074
36Calcium signaling pathway_Homo sapiens_hsa040201.07912467
37Dopaminergic synapse_Homo sapiens_hsa047281.04847409
38Base excision repair_Homo sapiens_hsa034101.04487829
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01252555
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98520455
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.97898706
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95607874
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94929317
44Cell cycle_Homo sapiens_hsa041100.92700875
45RNA polymerase_Homo sapiens_hsa030200.89660186
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89648655
47Nucleotide excision repair_Homo sapiens_hsa034200.88249627
48ErbB signaling pathway_Homo sapiens_hsa040120.87550020
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83585563
50Cocaine addiction_Homo sapiens_hsa050300.83335490
51VEGF signaling pathway_Homo sapiens_hsa043700.82791622
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.82022161
53Mismatch repair_Homo sapiens_hsa034300.79747049
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.79424568
55Fatty acid biosynthesis_Homo sapiens_hsa000610.79265090
56Glioma_Homo sapiens_hsa052140.78946246
57Choline metabolism in cancer_Homo sapiens_hsa052310.77359233
58Basal transcription factors_Homo sapiens_hsa030220.77255375
59Oxytocin signaling pathway_Homo sapiens_hsa049210.76436588
60Ether lipid metabolism_Homo sapiens_hsa005650.75850782
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75352181
62Linoleic acid metabolism_Homo sapiens_hsa005910.74833483
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74716141
64Non-small cell lung cancer_Homo sapiens_hsa052230.70351226
65Purine metabolism_Homo sapiens_hsa002300.70262127
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68527175
67MicroRNAs in cancer_Homo sapiens_hsa052060.68370673
68Phototransduction_Homo sapiens_hsa047440.65864491
69AMPK signaling pathway_Homo sapiens_hsa041520.64305585
70Gastric acid secretion_Homo sapiens_hsa049710.63554969
71Alcoholism_Homo sapiens_hsa050340.62287900
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62121156
73Dorso-ventral axis formation_Homo sapiens_hsa043200.61861025
74Oocyte meiosis_Homo sapiens_hsa041140.61492498
75Pyrimidine metabolism_Homo sapiens_hsa002400.61102879
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59582385
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59272818
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59260480
79Nitrogen metabolism_Homo sapiens_hsa009100.58431232
80Inositol phosphate metabolism_Homo sapiens_hsa005620.57081442
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56989806
82cAMP signaling pathway_Homo sapiens_hsa040240.53543917
83Bladder cancer_Homo sapiens_hsa052190.53003253
84Non-homologous end-joining_Homo sapiens_hsa034500.52897533
85Fructose and mannose metabolism_Homo sapiens_hsa000510.51470048
86Hedgehog signaling pathway_Homo sapiens_hsa043400.51421484
87Arginine and proline metabolism_Homo sapiens_hsa003300.49602752
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49452922
89Chronic myeloid leukemia_Homo sapiens_hsa052200.48515764
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46862470
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46121148
92Glycerolipid metabolism_Homo sapiens_hsa005610.45366066
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43661256
94Long-term depression_Homo sapiens_hsa047300.42911088
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41678589
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.40711046
97Synaptic vesicle cycle_Homo sapiens_hsa047210.39995578
98Salivary secretion_Homo sapiens_hsa049700.37236814
99Retinol metabolism_Homo sapiens_hsa008300.33312466
100N-Glycan biosynthesis_Homo sapiens_hsa005100.33289269

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »