FAM35A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.32712543
2L-phenylalanine catabolic process (GO:0006559)7.32712543
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.97779514
4L-phenylalanine metabolic process (GO:0006558)6.97779514
5aromatic amino acid family catabolic process (GO:0009074)6.66086885
6tryptophan catabolic process (GO:0006569)6.00924832
7indole-containing compound catabolic process (GO:0042436)6.00924832
8indolalkylamine catabolic process (GO:0046218)6.00924832
9bile acid biosynthetic process (GO:0006699)5.86764847
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80948600
11kynurenine metabolic process (GO:0070189)5.75099985
12tryptophan metabolic process (GO:0006568)5.73828396
13nuclear pore complex assembly (GO:0051292)5.64969670
14glyoxylate metabolic process (GO:0046487)5.53899732
15urea cycle (GO:0000050)5.52615507
16urea metabolic process (GO:0019627)5.52615507
17complement activation, alternative pathway (GO:0006957)5.33984305
18regulation of protein activation cascade (GO:2000257)5.32873631
19negative regulation of fibrinolysis (GO:0051918)5.29704244
20alpha-linolenic acid metabolic process (GO:0036109)5.25619058
21nuclear pore organization (GO:0006999)5.24029722
22serine family amino acid catabolic process (GO:0009071)5.16178264
23peptidyl-glutamic acid carboxylation (GO:0017187)5.15039334
24protein carboxylation (GO:0018214)5.15039334
25cysteine metabolic process (GO:0006534)5.11975432
26regulation of fibrinolysis (GO:0051917)5.11161260
27sulfur amino acid catabolic process (GO:0000098)5.10367931
28high-density lipoprotein particle remodeling (GO:0034375)5.07351394
29nitrogen cycle metabolic process (GO:0071941)5.04369181
30bile acid metabolic process (GO:0008206)5.00608774
31regulation of complement activation (GO:0030449)4.96597898
32aromatic amino acid family metabolic process (GO:0009072)4.83322066
33glycine metabolic process (GO:0006544)4.80523215
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71437496
35tyrosine metabolic process (GO:0006570)4.68899757
36ribosome assembly (GO:0042255)4.68659602
37lysine catabolic process (GO:0006554)4.63581151
38lysine metabolic process (GO:0006553)4.63581151
39homocysteine metabolic process (GO:0050667)4.62108850
40mitotic sister chromatid cohesion (GO:0007064)4.56139882
41amino-acid betaine metabolic process (GO:0006577)4.55236045
42regulation of triglyceride catabolic process (GO:0010896)4.54768581
43alpha-amino acid catabolic process (GO:1901606)4.53487407
44acylglycerol homeostasis (GO:0055090)4.43306908
45triglyceride homeostasis (GO:0070328)4.43306908
46reverse cholesterol transport (GO:0043691)4.42166382
47macromolecular complex remodeling (GO:0034367)4.38048203
48plasma lipoprotein particle remodeling (GO:0034369)4.38048203
49protein-lipid complex remodeling (GO:0034368)4.38048203
50serine family amino acid metabolic process (GO:0009069)4.33489253
51imidazole-containing compound metabolic process (GO:0052803)4.33000759
52regulation of cholesterol esterification (GO:0010872)4.32285083
53phospholipid efflux (GO:0033700)4.30454775
54bile acid and bile salt transport (GO:0015721)4.26688664
55indolalkylamine metabolic process (GO:0006586)4.26242873
56amine catabolic process (GO:0009310)4.18331689
57cellular biogenic amine catabolic process (GO:0042402)4.18331689
58serine family amino acid biosynthetic process (GO:0009070)4.15194919
59coenzyme catabolic process (GO:0009109)4.14955527
60pore complex assembly (GO:0046931)4.14525494
61cellular amino acid catabolic process (GO:0009063)4.11685194
62dicarboxylic acid biosynthetic process (GO:0043650)4.09585077
63negative regulation of cholesterol transport (GO:0032375)4.09140396
64negative regulation of sterol transport (GO:0032372)4.09140396
65cellular glucuronidation (GO:0052695)4.06712175
66plasma lipoprotein particle clearance (GO:0034381)4.06459672
67glutamate metabolic process (GO:0006536)3.94669556
68plasma lipoprotein particle assembly (GO:0034377)3.94121558
69ethanol oxidation (GO:0006069)3.91133891
70cholesterol efflux (GO:0033344)3.87250598
71fibrinolysis (GO:0042730)3.85453885
72aldehyde catabolic process (GO:0046185)3.85194625
73cellular ketone body metabolic process (GO:0046950)3.84561482
74benzene-containing compound metabolic process (GO:0042537)3.80062058
75cytolysis (GO:0019835)3.75959145
76complement activation, classical pathway (GO:0006958)3.74059430
77cellular modified amino acid catabolic process (GO:0042219)3.73522303
78mitotic metaphase plate congression (GO:0007080)3.70551073
79folic acid-containing compound biosynthetic process (GO:0009396)3.70485961
80low-density lipoprotein particle remodeling (GO:0034374)3.70232305
81very-low-density lipoprotein particle assembly (GO:0034379)3.70179157
82complement activation (GO:0006956)3.67308142
83blood coagulation, intrinsic pathway (GO:0007597)3.67224316
84non-recombinational repair (GO:0000726)3.67078602
85double-strand break repair via nonhomologous end joining (GO:0006303)3.67078602
86arginine metabolic process (GO:0006525)3.66901135
87phospholipid homeostasis (GO:0055091)3.64685878
88drug catabolic process (GO:0042737)3.60273253
89organic acid catabolic process (GO:0016054)3.59783053
90carboxylic acid catabolic process (GO:0046395)3.59783053
91negative regulation of lipase activity (GO:0060192)3.58808366
92protein activation cascade (GO:0072376)3.58528763
93acetyl-CoA metabolic process (GO:0006084)3.56888859
94cholesterol homeostasis (GO:0042632)3.51679166
95protein-lipid complex assembly (GO:0065005)3.51458953
96uronic acid metabolic process (GO:0006063)3.50726090
97glucuronate metabolic process (GO:0019585)3.50726090
98cofactor catabolic process (GO:0051187)3.50448315
99COPII vesicle coating (GO:0048208)3.47180617
100NAD biosynthetic process (GO:0009435)3.45703301
101regulation of cholesterol homeostasis (GO:2000188)3.45630797
102sterol homeostasis (GO:0055092)3.45590334
103plasma lipoprotein particle organization (GO:0071827)3.43059754
104positive regulation of triglyceride lipase activity (GO:0061365)3.42175700
105positive regulation of lipoprotein lipase activity (GO:0051006)3.42175700
106pyridine nucleotide biosynthetic process (GO:0019363)3.40421630
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.40421630
108regulation of centriole replication (GO:0046599)3.40359158
109one-carbon metabolic process (GO:0006730)3.40122929
110urate metabolic process (GO:0046415)3.39849537
111negative regulation of fatty acid biosynthetic process (GO:0045717)3.38184063
112metaphase plate congression (GO:0051310)3.32610430
113DNA unwinding involved in DNA replication (GO:0006268)3.30627585
114IMP biosynthetic process (GO:0006188)3.22261142
115CENP-A containing nucleosome assembly (GO:0034080)3.17161264
116mitotic nuclear envelope disassembly (GO:0007077)3.16510111
117IMP metabolic process (GO:0046040)3.13204760
118mitotic chromosome condensation (GO:0007076)3.09164829
119DNA strand elongation involved in DNA replication (GO:0006271)3.08334745
120proline biosynthetic process (GO:0006561)3.08325397
121chromatin remodeling at centromere (GO:0031055)3.07716851
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07178049
123protein localization to kinetochore (GO:0034501)3.05360627
124transcription from mitochondrial promoter (GO:0006390)3.00395167
125protein localization to chromosome, centromeric region (GO:0071459)3.00281589
126pteridine-containing compound biosynthetic process (GO:0042559)2.98076177
127DNA strand elongation (GO:0022616)2.96934517
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95577708
129establishment of integrated proviral latency (GO:0075713)2.94554371
130membrane disassembly (GO:0030397)2.93402457
131nuclear envelope disassembly (GO:0051081)2.93402457
132proteasome assembly (GO:0043248)2.93109682
133DNA ligation (GO:0006266)2.88591214
134AMP metabolic process (GO:0046033)2.88048455
135tetrahydrofolate metabolic process (GO:0046653)2.87837256
136mitotic G2/M transition checkpoint (GO:0044818)2.86997785
137mitotic recombination (GO:0006312)2.85998624
138purine nucleobase biosynthetic process (GO:0009113)2.84937640
139mitotic sister chromatid segregation (GO:0000070)2.83912665
140telomere maintenance via semi-conservative replication (GO:0032201)2.83106600
141DNA replication checkpoint (GO:0000076)2.82797606
142sister chromatid segregation (GO:0000819)2.81066215
143regulation of translational termination (GO:0006449)2.79081216
144sister chromatid cohesion (GO:0007062)2.78346260
145regulation of translational fidelity (GO:0006450)2.75128968
146tRNA aminoacylation for protein translation (GO:0006418)2.73846417
147mitochondrial RNA metabolic process (GO:0000959)2.73305270
148formation of translation preinitiation complex (GO:0001731)2.72251283
149establishment of chromosome localization (GO:0051303)2.72180021
150telomere maintenance via recombination (GO:0000722)2.70889970
151Golgi transport vesicle coating (GO:0048200)2.70883400
152COPI coating of Golgi vesicle (GO:0048205)2.70883400
153DNA duplex unwinding (GO:0032508)2.69793145
154amino acid activation (GO:0043038)2.68345210
155tRNA aminoacylation (GO:0043039)2.68345210
156isotype switching (GO:0045190)2.67405212
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67405212
158somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67405212
159nucleotide-sugar biosynthetic process (GO:0009226)2.66929412
160spindle checkpoint (GO:0031577)2.66431895
161mitotic G2 DNA damage checkpoint (GO:0007095)2.65492136
162mitotic spindle checkpoint (GO:0071174)2.64002294
163DNA geometric change (GO:0032392)2.63769414
164DNA replication initiation (GO:0006270)2.63329739
165regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63236418
166regulation of cytokine secretion involved in immune response (GO:0002739)2.62429462
167nucleobase-containing small molecule interconversion (GO:0015949)2.61395506
168tricarboxylic acid cycle (GO:0006099)2.58711071
169mRNA cleavage (GO:0006379)2.55266216
170nucleobase biosynthetic process (GO:0046112)2.53891086
171histone exchange (GO:0043486)2.53128847
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51533424
173folic acid-containing compound metabolic process (GO:0006760)2.50306413
174glutamine family amino acid biosynthetic process (GO:0009084)2.47396618
175somatic recombination of immunoglobulin gene segments (GO:0016447)2.47167979
176DNA replication-independent nucleosome organization (GO:0034724)2.45015406
177DNA replication-independent nucleosome assembly (GO:0006336)2.45015406
178regulation of DNA endoreduplication (GO:0032875)2.44725738
179regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43234694
180regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43234694
181regulation of coenzyme metabolic process (GO:0051196)2.41047517
182regulation of cofactor metabolic process (GO:0051193)2.41047517
183regulation of chromosome segregation (GO:0051983)2.40923476
184RNA-dependent DNA replication (GO:0006278)2.40858265
185keratinocyte development (GO:0003334)2.39808069
186negative regulation of chromosome segregation (GO:0051985)2.39658885
187negative regulation of sister chromatid segregation (GO:0033046)2.38954476
188negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.38954476
189negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.38954476
190negative regulation of mitotic sister chromatid segregation (GO:0033048)2.38954476
191negative regulation of mitotic sister chromatid separation (GO:2000816)2.38954476
192glutamine metabolic process (GO:0006541)2.38125304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.37215206
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.51982574
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.43358854
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.60371913
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.99869068
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25251088
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.17691615
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.96210137
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34635862
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.23351554
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.57337454
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53193751
13E2F7_22180533_ChIP-Seq_HELA_Human2.47253009
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.38720376
15ELK1_19687146_ChIP-ChIP_HELA_Human2.23172340
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.17673798
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09849502
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5087733
19PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99941977
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.95871509
21* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93453485
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90374945
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82732535
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76708492
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73952823
26* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66819275
27GATA1_22025678_ChIP-Seq_K562_Human1.62763758
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.62485510
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57460109
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55881976
31VDR_23849224_ChIP-Seq_CD4+_Human1.55424569
32TFEB_21752829_ChIP-Seq_HELA_Human1.51525902
33CLOCK_20551151_ChIP-Seq_293T_Human1.50127127
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49168746
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46987347
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40955555
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40397022
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.39674789
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33033516
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23609948
41GABP_19822575_ChIP-Seq_HepG2_Human1.21270523
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18210548
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17738800
44SOX17_20123909_ChIP-Seq_XEN_Mouse1.15917793
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14918117
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.13438525
47HTT_18923047_ChIP-ChIP_STHdh_Human1.12485303
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08735834
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07177713
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06066921
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.05532572
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04861500
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.04455534
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.04136511
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03813603
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03593585
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02938982
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02156273
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00932382
60* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00161148
61CHD1_26751641_Chip-Seq_LNCaP_Human0.98785839
62AR_21909140_ChIP-Seq_LNCAP_Human0.98718925
63TTF2_22483619_ChIP-Seq_HELA_Human0.98581326
64KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96908231
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96486050
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93684167
67BRD4_25478319_ChIP-Seq_HGPS_Human0.92372567
68ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92045196
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90113520
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.89794542
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89445822
72PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88900179
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88467448
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88059023
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87690171
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86435105
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86395456
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85938331
79GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85380246
80ELF5_23300383_ChIP-Seq_T47D_Human0.85304806
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84817704
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84609317
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84367012
84FUS_26573619_Chip-Seq_HEK293_Human0.83978363
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83065002
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83060033
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82401571
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82051319
89SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81772043
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79560601
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.79486558
92IRF1_19129219_ChIP-ChIP_H3396_Human0.79030897
93XRN2_22483619_ChIP-Seq_HELA_Human0.78827012
94SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77358738
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76967275
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75679881
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74782516
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73351138
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72998359
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71202343
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70119153
102RARA_24833708_ChIP-Seq_LIVER_Mouse0.69568740
103GATA4_25053715_ChIP-Seq_YYC3_Human0.69375232
104NELFA_20434984_ChIP-Seq_ESCs_Mouse0.68373299
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68282313
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68069041
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67969801
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.67640762
109* RARB_24833708_ChIP-Seq_LIVER_Mouse0.67536115
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.67054881
111MYC_22102868_ChIP-Seq_BL_Human0.66730562
112ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65551439
113EGR1_19374776_ChIP-ChIP_THP-1_Human0.65256657
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64362325
115SCL_19346495_ChIP-Seq_HPC-7_Human0.62469992
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61530280
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61276042
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.60934114
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.60857726
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60005673
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.59691766
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.59557472
123CREB1_15753290_ChIP-ChIP_HEK293T_Human0.58854382
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.57919195
125DCP1A_22483619_ChIP-Seq_HELA_Human0.57874557
126ZNF263_19887448_ChIP-Seq_K562_Human0.57515638
127MYB_26560356_Chip-Seq_TH1_Human0.57366367
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.57303104
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56899593
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.56544287
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.55687074
132AR_20517297_ChIP-Seq_VCAP_Human0.55524751
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.55417643
134FOXP3_21729870_ChIP-Seq_TREG_Human0.54737669
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54690760
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.53985091
137KDM5A_27292631_Chip-Seq_BREAST_Human0.52655994
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.52581414
139HOXB4_20404135_ChIP-ChIP_EML_Mouse0.52012570
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.51999130
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.51571464
142GATA6_25053715_ChIP-Seq_YYC3_Human0.51533801
143EST1_17652178_ChIP-ChIP_JURKAT_Human0.50877237
144ERG_20517297_ChIP-Seq_VCAP_Human0.50057933
145MYCN_18555785_ChIP-Seq_MESCs_Mouse0.49729147
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49332698
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.49060876
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.49060876
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.49060876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.87846637
2MP0005360_urolithiasis6.90622418
3MP0005085_abnormal_gallbladder_physiolo6.12815551
4MP0005365_abnormal_bile_salt5.87744892
5MP0003806_abnormal_nucleotide_metabolis4.64834129
6MP0008875_abnormal_xenobiotic_pharmacok4.55829038
7MP0008057_abnormal_DNA_replication3.69417453
8MP0003252_abnormal_bile_duct3.66550430
9MP0010329_abnormal_lipoprotein_level3.29743493
10MP0010094_abnormal_chromosome_stability3.29558383
11MP0009840_abnormal_foam_cell3.03402202
12MP0010352_gastrointestinal_tract_polyps2.97770427
13MP0004957_abnormal_blastocyst_morpholog2.90364817
14MP0005083_abnormal_biliary_tract2.74491027
15MP0006054_spinal_hemorrhage2.70207607
16MP0003693_abnormal_embryo_hatching2.66251943
17MP0005332_abnormal_amino_acid2.51424023
18MP0003111_abnormal_nucleus_morphology2.50666122
19MP0001666_abnormal_nutrient_absorption2.39000049
20MP0003195_calcinosis2.22245491
21MP0000609_abnormal_liver_physiology2.21698898
22MP0008058_abnormal_DNA_repair2.20874089
23MP0003191_abnormal_cellular_cholesterol2.15866343
24MP0009697_abnormal_copulation2.10487891
25MP0010234_abnormal_vibrissa_follicle2.05473691
26MP0002138_abnormal_hepatobiliary_system2.05059336
27MP0003077_abnormal_cell_cycle2.02236351
28MP0003868_abnormal_feces_composition1.95024813
29MP0008007_abnormal_cellular_replicative1.90671733
30MP0002118_abnormal_lipid_homeostasis1.89731688
31MP0003941_abnormal_skin_development1.85585315
32MP0004019_abnormal_vitamin_homeostasis1.84910846
33MP0005319_abnormal_enzyme/_coenzyme1.80774062
34MP0003890_abnormal_embryonic-extraembry1.72428415
35MP0001764_abnormal_homeostasis1.70940382
36MP0010307_abnormal_tumor_latency1.68688848
37MP0003950_abnormal_plasma_membrane1.64342313
38MP0002877_abnormal_melanocyte_morpholog1.55150273
39MP0001730_embryonic_growth_arrest1.54371822
40MP0003186_abnormal_redox_activity1.51793759
41MP0000537_abnormal_urethra_morphology1.51745667
42MP0005670_abnormal_white_adipose1.51676027
43MP0005367_renal/urinary_system_phenotyp1.50115190
44MP0000516_abnormal_urinary_system1.50115190
45MP0008932_abnormal_embryonic_tissue1.49030826
46MP0003315_abnormal_perineum_morphology1.42105892
47MP0005451_abnormal_body_composition1.39683730
48MP0005380_embryogenesis_phenotype1.37191336
49MP0001672_abnormal_embryogenesis/_devel1.37191336
50MP0000598_abnormal_liver_morphology1.34846531
51MP0002254_reproductive_system_inflammat1.34449246
52MP0005584_abnormal_enzyme/coenzyme_acti1.33930472
53MP0003984_embryonic_growth_retardation1.33746450
54MP0002088_abnormal_embryonic_growth/wei1.31592719
55MP0001697_abnormal_embryo_size1.31516024
56MP0000350_abnormal_cell_proliferation1.31103788
57MP0003656_abnormal_erythrocyte_physiolo1.30412952
58MP0003011_delayed_dark_adaptation1.24170648
59MP0002086_abnormal_extraembryonic_tissu1.22404685
60MP0009643_abnormal_urine_homeostasis1.21333463
61MP0009763_increased_sensitivity_to1.17856224
62MP0003943_abnormal_hepatobiliary_system1.17292357
63MP0002009_preneoplasia1.15541827
64MP0003786_premature_aging1.13414588
65MP0005408_hypopigmentation1.09320955
66MP0002080_prenatal_lethality1.05050509
67MP0008469_abnormal_protein_level1.02614862
68MP0002166_altered_tumor_susceptibility1.01431118
69MP0009765_abnormal_xenobiotic_induced1.00462142
70MP0004185_abnormal_adipocyte_glucose0.99415214
71MP0005647_abnormal_sex_gland0.98637044
72MP0003718_maternal_effect0.97257151
73MP0002084_abnormal_developmental_patter0.97050370
74MP0005379_endocrine/exocrine_gland_phen0.95841822
75MP0003566_abnormal_cell_adhesion0.95141308
76MP0006036_abnormal_mitochondrial_physio0.94237930
77MP0002006_tumorigenesis0.91879868
78MP0005220_abnormal_exocrine_pancreas0.91555536
79MP0003763_abnormal_thymus_physiology0.90150985
80MP0003705_abnormal_hypodermis_morpholog0.89816529
81MP0008004_abnormal_stomach_pH0.89509680
82MP0009764_decreased_sensitivity_to0.88515581
83MP0005058_abnormal_lysosome_morphology0.88292883
84MP0002132_abnormal_respiratory_system0.86838489
85MP0010368_abnormal_lymphatic_system0.86539636
86MP0002090_abnormal_vision0.84728090
87MP0002971_abnormal_brown_adipose0.82978559
88MP0004808_abnormal_hematopoietic_stem0.82474034
89MP0000313_abnormal_cell_death0.82332906
90MP0009642_abnormal_blood_homeostasis0.82041596
91MP0005076_abnormal_cell_differentiation0.81867253
92MP0004272_abnormal_basement_membrane0.79440422
93MP0005636_abnormal_mineral_homeostasis0.78177259
94MP0002078_abnormal_glucose_homeostasis0.78121612
95MP0002019_abnormal_tumor_incidence0.77791663
96MP0003221_abnormal_cardiomyocyte_apopto0.77553281
97MP0001727_abnormal_embryo_implantation0.76573664
98MP0005376_homeostasis/metabolism_phenot0.76241710
99MP0010678_abnormal_skin_adnexa0.74883484
100MP0001881_abnormal_mammary_gland0.74224595
101MP0003436_decreased_susceptibility_to0.73238097
102MP0005334_abnormal_fat_pad0.73011191
103MP0005266_abnormal_metabolism0.72309763
104MP0005187_abnormal_penis_morphology0.72261316
105MP0005464_abnormal_platelet_physiology0.71196133
106MP0002085_abnormal_embryonic_tissue0.70611774
107MP0005084_abnormal_gallbladder_morpholo0.69717783
108MP0003567_abnormal_fetal_cardiomyocyte0.69715431
109MP0004233_abnormal_muscle_weight0.68568733
110MP0000358_abnormal_cell_content/0.67531578
111MP0005621_abnormal_cell_physiology0.67276206
112MP0003300_gastrointestinal_ulcer0.66341704
113MP0001853_heart_inflammation0.65860731
114MP0001661_extended_life_span0.65399724
115MP0002928_abnormal_bile_duct0.65321881
116MP0009703_decreased_birth_body0.64473674
117MP0005395_other_phenotype0.64412114
118MP0002796_impaired_skin_barrier0.64132217
119MP0000604_amyloidosis0.63249682
120MP0003724_increased_susceptibility_to0.60674336
121MP0004130_abnormal_muscle_cell0.58757455
122MP0008873_increased_physiological_sensi0.56081171
123MP0006035_abnormal_mitochondrial_morpho0.55111612
124MP0005666_abnormal_adipose_tissue0.53221068
125MP0004381_abnormal_hair_follicle0.51939925
126MP0002970_abnormal_white_adipose0.51524668
127MP0009053_abnormal_anal_canal0.50847181
128MP0001845_abnormal_inflammatory_respons0.49769290
129MP0002396_abnormal_hematopoietic_system0.49710839
130MP0005023_abnormal_wound_healing0.49475236
131MP0000639_abnormal_adrenal_gland0.49465830
132MP0002136_abnormal_kidney_physiology0.49414732
133MP0001756_abnormal_urination0.49169366
134MP0001243_abnormal_dermal_layer0.47351744
135MP0009672_abnormal_birth_weight0.47154235
136MP0009115_abnormal_fat_cell0.45975539
137MP0002876_abnormal_thyroid_physiology0.45000795
138MP0005075_abnormal_melanosome_morpholog0.44502286
139MP0002060_abnormal_skin_morphology0.44216279
140MP0004264_abnormal_extraembryonic_tissu0.42375729
141MP0001800_abnormal_humoral_immune0.40918605
142MP0005448_abnormal_energy_balance0.39599277
143MP0001915_intracranial_hemorrhage0.38880671
144MP0000689_abnormal_spleen_morphology0.37028232
145MP0004947_skin_inflammation0.36854735
146MP0000685_abnormal_immune_system0.36402143
147MP0001944_abnormal_pancreas_morphology0.35396160
148MP0006082_CNS_inflammation0.35154735
149MP0001835_abnormal_antigen_presentation0.35133514
150MP0001545_abnormal_hematopoietic_system0.34467730
151MP0005397_hematopoietic_system_phenotyp0.34467730
152MP0005535_abnormal_body_temperature0.34052979
153MP0003638_abnormal_response/metabolism_0.34037853
154MP0002419_abnormal_innate_immunity0.33737661
155MP0000427_abnormal_hair_cycle0.33573162
156MP0003699_abnormal_female_reproductive0.32928160
157MP0002269_muscular_atrophy0.31619780
158MP0002135_abnormal_kidney_morphology0.31121104
159MP0003953_abnormal_hormone_level0.31105051
160MP0001119_abnormal_female_reproductive0.30944230
161MP0005166_decreased_susceptibility_to0.30252575

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.50856892
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.04754165
3Deep venous thrombosis (HP:0002625)6.87121960
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.73112625
5Hypobetalipoproteinemia (HP:0003563)6.53057466
6Prolonged partial thromboplastin time (HP:0003645)6.25557813
7Xanthomatosis (HP:0000991)6.04131171
8Complement deficiency (HP:0004431)5.17795528
9Hyperlipoproteinemia (HP:0010980)5.14449366
10Hypolipoproteinemia (HP:0010981)4.88116916
11Abnormality of methionine metabolism (HP:0010901)4.77912215
12Abnormality of the common coagulation pathway (HP:0010990)4.63825291
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.49107868
14Hypoglycemic coma (HP:0001325)4.41211356
15Epidermoid cyst (HP:0200040)4.38798667
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.38620457
17Joint hemorrhage (HP:0005261)4.38294593
18Hyperammonemia (HP:0001987)4.35300531
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.34397203
20Hyperglycinemia (HP:0002154)4.32752456
21Abnormality of pyrimidine metabolism (HP:0004353)4.27358409
22Fat malabsorption (HP:0002630)4.26871431
23Hypoalphalipoproteinemia (HP:0003233)4.18251750
24Abnormality of the intrinsic pathway (HP:0010989)3.99775313
25Ketosis (HP:0001946)3.94468700
26Abnormality of complement system (HP:0005339)3.79931838
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77250859
28Hyperglycinuria (HP:0003108)3.73940741
29Conjugated hyperbilirubinemia (HP:0002908)3.73216439
30Abnormality of serine family amino acid metabolism (HP:0010894)3.71644156
31Abnormality of glycine metabolism (HP:0010895)3.71644156
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.62353849
33Multiple enchondromatosis (HP:0005701)3.60514493
34Chromsome breakage (HP:0040012)3.51461449
35Hypercholesterolemia (HP:0003124)3.33544432
36Steatorrhea (HP:0002570)3.31173033
37Hyperbilirubinemia (HP:0002904)3.29959881
38Abnormality of serum amino acid levels (HP:0003112)3.19707937
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17260290
40Abnormality of nucleobase metabolism (HP:0010932)3.11935243
41Abnormality of chromosome stability (HP:0003220)3.10370503
42Abnormality of fatty-acid metabolism (HP:0004359)3.06222469
43Abnormal foot bone ossification (HP:0010675)2.99053543
44Spontaneous abortion (HP:0005268)2.93742239
45Hypochromic microcytic anemia (HP:0004840)2.92940732
46Myocardial infarction (HP:0001658)2.91148821
47Delayed CNS myelination (HP:0002188)2.86884493
48Hepatocellular carcinoma (HP:0001402)2.81606168
49Ketoacidosis (HP:0001993)2.72583360
50Hypoglycemic seizures (HP:0002173)2.70987970
51Abnormal tarsal ossification (HP:0008369)2.69754617
52Skin nodule (HP:0200036)2.67071546
53Spastic diplegia (HP:0001264)2.60624683
54Abnormality of the fetal cardiovascular system (HP:0010948)2.58893628
55Abnormal umbilical cord blood vessels (HP:0011403)2.58893628
56Single umbilical artery (HP:0001195)2.58893628
57Dicarboxylic aciduria (HP:0003215)2.58403488
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58403488
59Renal cortical cysts (HP:0000803)2.55182507
60Acanthocytosis (HP:0001927)2.54907950
61Abnormality of purine metabolism (HP:0004352)2.54223661
62Pancreatic islet-cell hyperplasia (HP:0004510)2.53424930
63Metabolic acidosis (HP:0001942)2.48663248
64Rhabdomyosarcoma (HP:0002859)2.48082287
65Lethargy (HP:0001254)2.47487148
66Nephroblastoma (Wilms tumor) (HP:0002667)2.45866770
67Progressive external ophthalmoplegia (HP:0000590)2.45111747
68Recurrent gram-negative bacterial infections (HP:0005420)2.44990276
69Volvulus (HP:0002580)2.44853286
70Gingival bleeding (HP:0000225)2.44260728
71Generalized aminoaciduria (HP:0002909)2.40700587
72Embryonal renal neoplasm (HP:0011794)2.37992697
73Increased serum pyruvate (HP:0003542)2.35326669
74Abnormality of the umbilical cord (HP:0010881)2.34327675
75Systemic lupus erythematosus (HP:0002725)2.32947620
76Abnormality of the preputium (HP:0100587)2.30647143
77Hyperinsulinemic hypoglycemia (HP:0000825)2.29552724
78Papillary thyroid carcinoma (HP:0002895)2.28195399
79Abnormality of glycolysis (HP:0004366)2.27483336
80Pancreatitis (HP:0001733)2.24229220
81Malnutrition (HP:0004395)2.24023219
82Thrombophlebitis (HP:0004418)2.23741092
83Autoimmune hemolytic anemia (HP:0001890)2.19140580
84Late onset (HP:0003584)2.17845600
85Abnormal gallbladder morphology (HP:0012437)2.16753023
86Irritability (HP:0000737)2.16490503
87Reduced antithrombin III activity (HP:0001976)2.16448244
88Anal stenosis (HP:0002025)2.12523881
89Neonatal onset (HP:0003623)2.11983602
90Mitral stenosis (HP:0001718)2.11561570
91Glomerulonephritis (HP:0000099)2.10652671
92Abnormality of iron homeostasis (HP:0011031)2.10163986
93Hyperglycemia (HP:0003074)2.09802491
94Acute myeloid leukemia (HP:0004808)2.09780272
95Abnormalities of placenta or umbilical cord (HP:0001194)2.09736169
96Esophageal varix (HP:0002040)2.08913818
97Cerebral edema (HP:0002181)2.07295562
98Septate vagina (HP:0001153)2.06801944
99Opisthotonus (HP:0002179)2.05999143
100Cholelithiasis (HP:0001081)2.05805524
101Meckel diverticulum (HP:0002245)2.05694677
102Abnormal cartilage morphology (HP:0002763)2.05059682
103Tetraparesis (HP:0002273)2.04024297
104Deep philtrum (HP:0002002)2.01998217
105Medulloblastoma (HP:0002885)2.01237954
106Gout (HP:0001997)2.00912937
107Abnormality of transition element cation homeostasis (HP:0011030)1.98920033
108Abnormal gallbladder physiology (HP:0012438)1.97640957
109Cholecystitis (HP:0001082)1.97640957
110Elevated hepatic transaminases (HP:0002910)1.97465157
111Vascular calcification (HP:0004934)1.96885898
112Enlarged kidneys (HP:0000105)1.96362054
113Ovarian neoplasm (HP:0100615)1.95780504
114Subcapsular cataract (HP:0000523)1.94572776
115Secondary amenorrhea (HP:0000869)1.94308740
116Neoplasm of the adrenal gland (HP:0100631)1.92768164
117Abnormality of carpal bone ossification (HP:0006257)1.92385904
118Abnormality of the ileum (HP:0001549)1.92228507
119Brushfield spots (HP:0001088)1.91976884
120Megaloblastic anemia (HP:0001889)1.91618617
121Menorrhagia (HP:0000132)1.91032573
122Myelodysplasia (HP:0002863)1.89809612
123Premature ovarian failure (HP:0008209)1.89366749
124Deviation of the thumb (HP:0009603)1.88839783
125Proximal tubulopathy (HP:0000114)1.88588923
126Amyloidosis (HP:0011034)1.88153645
127Thyroid carcinoma (HP:0002890)1.86371767
128Abnormal enzyme/coenzyme activity (HP:0012379)1.84676005
129Increased nuchal translucency (HP:0010880)1.84527958
130Vomiting (HP:0002013)1.84006797
131Poikilocytosis (HP:0004447)1.83419164
132Asymmetry of the thorax (HP:0001555)1.82799878
133Abnormality of vitamin metabolism (HP:0100508)1.81122734
134Sensorimotor neuropathy (HP:0007141)1.81033273
135Abnormality of the Achilles tendon (HP:0005109)1.79901473
136Posterior subcapsular cataract (HP:0007787)1.79652725
137Proximal placement of thumb (HP:0009623)1.79576022
138Neoplasm of the small intestine (HP:0100833)1.77970006
139Acute hepatic failure (HP:0006554)1.77159385
140Abnormal auditory evoked potentials (HP:0006958)1.76310478
141Symptomatic seizures (HP:0011145)1.76163662
142Abnormality of the anterior horn cell (HP:0006802)1.75233849
143Degeneration of anterior horn cells (HP:0002398)1.75233849
144Overlapping toe (HP:0001845)1.74011579
145Hypoplasia of the thymus (HP:0000778)1.73375954
146Abnormality of alanine metabolism (HP:0010916)1.73052739
147Hyperalaninemia (HP:0003348)1.73052739
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73052739
149Curly hair (HP:0002212)1.72548070
150Orthostatic hypotension (HP:0001278)1.72235562
151Blepharitis (HP:0000498)1.72137556
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.70936699
153Cardiovascular calcification (HP:0011915)1.70910177
154Increased mean platelet volume (HP:0011877)1.70146833
155Limb hypertonia (HP:0002509)1.69928278
156Abnormality of the gallbladder (HP:0005264)1.69905683
157Nausea (HP:0002018)1.69486327
158Ureteral duplication (HP:0000073)1.68819219
159Gonadal dysgenesis (HP:0000133)1.68739443
160Dyschromatopsia (HP:0007641)1.65847165
161Joint swelling (HP:0001386)1.65682049
162Type I transferrin isoform profile (HP:0003642)1.65664268
163Fatigue (HP:0012378)1.64645857
164Abnormal biliary tract morphology (HP:0012440)1.63478871
165Abnormality of the duodenum (HP:0002246)1.63037385
166IgA deficiency (HP:0002720)1.62893377
167Microvesicular hepatic steatosis (HP:0001414)1.62550172
168Abnormal pancreas size (HP:0012094)1.62465086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.98588475
2PBK3.74723356
3FLT33.46422776
4TSSK63.44056650
5FGFR43.18288901
6ERN13.16616627
7TAOK33.15581881
8SCYL23.00517612
9SIK12.90836082
10NEK12.75423827
11TRIM282.69449110
12ERBB42.68407805
13PDK22.50494916
14MST42.47335943
15STK162.38225096
16LATS12.10163576
17TAF12.09355542
18MAP2K32.06294876
19SRPK12.05808011
20MAP3K122.04195513
21PKN21.91740364
22TYK21.90958969
23INSRR1.89608660
24PIK3CG1.86207503
25NEK91.84027957
26MKNK21.82800770
27MAP3K101.81684611
28MAP3K61.79114682
29MKNK11.67096714
30MAPK111.61213246
31PLK31.52315518
32ERBB31.48433701
33BUB11.46937993
34ACVR1B1.44809272
35PRKD31.43742030
36EIF2AK11.38021982
37BRD41.31451917
38KDR1.30540975
39JAK21.24035724
40CSF1R1.23521508
41ZAK1.17399279
42MAP2K41.17283383
43ABL21.15981449
44PNCK1.14298427
45MAP3K31.14291425
46PLK11.12744765
47MAP3K141.09511608
48MAP4K11.09110548
49BMPR21.07470557
50IRAK31.07203327
51STK101.05083776
52CDK61.04145353
53MAPK41.02922741
54PASK1.02052152
55JAK10.99905475
56TBK10.98197920
57SIK30.97970605
58NME20.96809747
59CSK0.96232977
60TIE10.94371596
61MAPK150.94227227
62PTK60.92361351
63ATR0.90605247
64PAK40.90204611
65MELK0.89016146
66CLK10.88447245
67KIT0.87188865
68CDK40.86479484
69JAK30.85790976
70PIM10.82940098
71TGFBR20.81149646
72CAMK1D0.80055735
73MAP3K70.79295131
74TTK0.79199382
75NLK0.79100613
76RPS6KA40.78462601
77ATM0.77448681
78FGFR10.77363822
79PRKAA20.77248219
80STK38L0.77185258
81TGFBR10.77138236
82CHEK10.76511780
83ALK0.76006331
84BMPR1B0.74455573
85STK30.72755852
86CDC70.72422648
87MAP3K50.72024535
88ITK0.70145431
89EPHA20.70072628
90BRSK20.69643406
91CHEK20.69556399
92FRK0.69125282
93FGFR20.68034611
94NUAK10.65470944
95BCR0.65276016
96PINK10.65088574
97RIPK10.63757695
98RPS6KB20.63497958
99MAPK70.63401098
100ZAP700.62150428
101GRK60.61731746
102AKT30.60897130
103YES10.60272647
104ABL10.59883524
105WEE10.59224701
106EIF2AK30.57374288
107MAP3K80.56989748
108MET0.56912843
109TEC0.56457525
110PLK40.56309529
111BTK0.56025858
112STK40.54311772
113MST1R0.53388583
114IKBKE0.53364166
115IKBKB0.53196585
116GSK3A0.51511630
117MAP2K60.51337756
118ICK0.51052404
119TRPM70.50856242
120FGFR30.50686752
121MAP2K20.50388861
122ERBB20.50291208
123EEF2K0.50179239
124BRSK10.49052492
125AURKB0.48198840
126CSNK2A20.47477556
127WNK30.47301048
128NEK60.47027622
129FGR0.46590900
130NEK20.46284890
131PRKAA10.45276309
132STK390.44484099
133CDK70.44239330
134MAPKAPK30.43426818
135IGF1R0.43143788
136LYN0.42568332
137TRIB30.42025323
138EIF2AK20.40402568
139CHUK0.39962565
140MTOR0.39570215
141MAPK120.39061251
142RPS6KB10.37096419
143ILK0.36773776
144CSNK1G10.36701203
145PRKACG0.36383136
146LATS20.36340607
147MAP3K110.35488781
148VRK10.35016416
149CSNK2A10.33721376
150CSNK1E0.33553019
151CDK10.33327495
152STK240.33257784
153CDK30.33045407
154CDK80.32168667
155RAF10.30661068
156PDGFRA0.25997910
157DAPK10.24815603

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55796266
2Nitrogen metabolism_Homo sapiens_hsa009103.48024020
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30025163
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10769737
5Arginine biosynthesis_Homo sapiens_hsa002203.05756031
6Complement and coagulation cascades_Homo sapiens_hsa046102.73469551
7Tryptophan metabolism_Homo sapiens_hsa003802.64062378
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58109361
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51177958
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50462428
11Fatty acid degradation_Homo sapiens_hsa000712.43904862
12Proteasome_Homo sapiens_hsa030502.40330229
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32872246
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19635278
15Peroxisome_Homo sapiens_hsa041462.06248773
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96679327
17Selenocompound metabolism_Homo sapiens_hsa004501.96473171
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.93353673
19RNA transport_Homo sapiens_hsa030131.88113675
20Butanoate metabolism_Homo sapiens_hsa006501.87058339
21Propanoate metabolism_Homo sapiens_hsa006401.81670892
22Histidine metabolism_Homo sapiens_hsa003401.79756647
23Chemical carcinogenesis_Homo sapiens_hsa052041.78343871
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78029178
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75523920
26PPAR signaling pathway_Homo sapiens_hsa033201.75224416
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.74293826
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69902570
29Fatty acid metabolism_Homo sapiens_hsa012121.68401856
30beta-Alanine metabolism_Homo sapiens_hsa004101.68070402
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67696557
32Cell cycle_Homo sapiens_hsa041101.66287425
33Staphylococcus aureus infection_Homo sapiens_hsa051501.65867529
34Caffeine metabolism_Homo sapiens_hsa002321.61112683
35Retinol metabolism_Homo sapiens_hsa008301.59301013
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.52679846
37Nucleotide excision repair_Homo sapiens_hsa034201.50777579
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.49045260
39Phenylalanine metabolism_Homo sapiens_hsa003601.46220568
40One carbon pool by folate_Homo sapiens_hsa006701.45792634
41Folate biosynthesis_Homo sapiens_hsa007901.43887428
42Spliceosome_Homo sapiens_hsa030401.38726097
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36315031
44Tyrosine metabolism_Homo sapiens_hsa003501.32728602
45Fanconi anemia pathway_Homo sapiens_hsa034601.31337408
46Sulfur metabolism_Homo sapiens_hsa009201.29360972
47Pyruvate metabolism_Homo sapiens_hsa006201.26955435
48Basal transcription factors_Homo sapiens_hsa030221.26547137
49Biosynthesis of amino acids_Homo sapiens_hsa012301.25782121
50Fatty acid elongation_Homo sapiens_hsa000621.23934957
51Starch and sucrose metabolism_Homo sapiens_hsa005001.21353737
52Bile secretion_Homo sapiens_hsa049761.20420270
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16305060
54ABC transporters_Homo sapiens_hsa020101.15060606
55Sulfur relay system_Homo sapiens_hsa041221.12887501
56Carbon metabolism_Homo sapiens_hsa012001.09882773
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05128459
58Steroid biosynthesis_Homo sapiens_hsa001001.04359557
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.01840095
60Arginine and proline metabolism_Homo sapiens_hsa003301.00683030
61Fat digestion and absorption_Homo sapiens_hsa049750.99703575
62Vitamin B6 metabolism_Homo sapiens_hsa007500.97646192
63N-Glycan biosynthesis_Homo sapiens_hsa005100.95801277
64Lysine degradation_Homo sapiens_hsa003100.91074212
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85749534
66Other glycan degradation_Homo sapiens_hsa005110.82068889
67Vitamin digestion and absorption_Homo sapiens_hsa049770.78545661
68mRNA surveillance pathway_Homo sapiens_hsa030150.78304020
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75070230
70Sphingolipid metabolism_Homo sapiens_hsa006000.70087174
71Glutathione metabolism_Homo sapiens_hsa004800.69117955
72Pentose phosphate pathway_Homo sapiens_hsa000300.68973286
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68696121
74Purine metabolism_Homo sapiens_hsa002300.67482075
75p53 signaling pathway_Homo sapiens_hsa041150.66555672
76RNA polymerase_Homo sapiens_hsa030200.65938430
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65794060
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62537567
79Thyroid cancer_Homo sapiens_hsa052160.58976407
80Glycerolipid metabolism_Homo sapiens_hsa005610.58383978
81Legionellosis_Homo sapiens_hsa051340.54089280
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48801330
83Metabolic pathways_Homo sapiens_hsa011000.48693644
84Renin-angiotensin system_Homo sapiens_hsa046140.48200741
85TGF-beta signaling pathway_Homo sapiens_hsa043500.48173798
86Fatty acid biosynthesis_Homo sapiens_hsa000610.47892094
87Protein export_Homo sapiens_hsa030600.44421942
88Herpes simplex infection_Homo sapiens_hsa051680.42106792
89Viral carcinogenesis_Homo sapiens_hsa052030.39830381
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39730200
91Pancreatic cancer_Homo sapiens_hsa052120.34088350
92Small cell lung cancer_Homo sapiens_hsa052220.29146993
93Oocyte meiosis_Homo sapiens_hsa041140.29059513
94Galactose metabolism_Homo sapiens_hsa000520.28158346
95Adherens junction_Homo sapiens_hsa045200.27233064
96Prion diseases_Homo sapiens_hsa050200.26509451
97Non-homologous end-joining_Homo sapiens_hsa034500.24895403
98Epstein-Barr virus infection_Homo sapiens_hsa051690.23625105
99Insulin resistance_Homo sapiens_hsa049310.22229898
100Pyrimidine metabolism_Homo sapiens_hsa002400.21150864
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20019486
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18704698
103Fructose and mannose metabolism_Homo sapiens_hsa000510.18681447
104Linoleic acid metabolism_Homo sapiens_hsa005910.17181239
105Systemic lupus erythematosus_Homo sapiens_hsa053220.16778064
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15317161
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.13377719
108Homologous recombination_Homo sapiens_hsa034400.11559064
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11230070
110Mismatch repair_Homo sapiens_hsa034300.10779141
111DNA replication_Homo sapiens_hsa030300.09514194
112Glucagon signaling pathway_Homo sapiens_hsa049220.07559709
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05411020
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.03164206
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.00137367
116NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1427189
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1347331
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1302130
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1198051
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1171076
121RNA degradation_Homo sapiens_hsa03018-0.1111407
122Primary immunodeficiency_Homo sapiens_hsa05340-0.1032467
123Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0987807
124Base excision repair_Homo sapiens_hsa03410-0.0977730
125Regulation of autophagy_Homo sapiens_hsa04140-0.0778205
126AMPK signaling pathway_Homo sapiens_hsa04152-0.0385036

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