ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.62082087
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.39625389
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.25283579
4	protein neddylation (GO:0045116)	4.20868743
5	proteasome assembly (GO:0043248)	4.18383471
6	pseudouridine synthesis (GO:0001522)	3.93285720
7	chaperone-mediated protein transport (GO:0072321)	3.91938952
8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.90619206
9	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.90113491
10	ATP synthesis coupled proton transport (GO:0015986)	3.86023906
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.86023906
12	respiratory chain complex IV assembly (GO:0008535)	3.78246543
13	S-adenosylmethionine metabolic process (GO:0046500)	3.75021479
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55014037
15	protein complex biogenesis (GO:0070271)	3.50541925
16	chromatin remodeling at centromere (GO:0031055)	3.50507558
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.43226001
18	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.41475904
19	L-phenylalanine catabolic process (GO:0006559)	3.41475904
20	regulation of activation of Janus kinase activity (GO:0010533)	3.36062860
21	CENP-A containing nucleosome assembly (GO:0034080)	3.33777402
22	ribosomal large subunit biogenesis (GO:0042273)	3.31319018
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27180627
24	NADH dehydrogenase complex assembly (GO:0010257)	3.27180627
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27180627
26	L-phenylalanine metabolic process (GO:0006558)	3.27008636
27	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.27008636
28	glyoxylate metabolic process (GO:0046487)	3.24780830
29	purine nucleobase biosynthetic process (GO:0009113)	3.23892110
30	cytochrome complex assembly (GO:0017004)	3.21683261
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.20040277
32	xenobiotic catabolic process (GO:0042178)	3.16603510
33	exogenous drug catabolic process (GO:0042738)	3.15139189
34	response to nitrosative stress (GO:0051409)	3.13161634
35	aromatic amino acid family catabolic process (GO:0009074)	3.09293312
36	DNA deamination (GO:0045006)	3.07719088
37	uronic acid metabolic process (GO:0006063)	3.05297393
38	glucuronate metabolic process (GO:0019585)	3.05297393
39	respiratory electron transport chain (GO:0022904)	3.02736493
40	electron transport chain (GO:0022900)	3.00489753
41	bile acid biosynthetic process (GO:0006699)	2.93735454
42	cullin deneddylation (GO:0010388)	2.93486054
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92805805
44	regulation of cellular amino acid metabolic process (GO:0006521)	2.91951776
45	platelet dense granule organization (GO:0060155)	2.90405992
46	histone exchange (GO:0043486)	2.90258091
47	protein-cofactor linkage (GO:0018065)	2.89849774
48	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.89588346
49	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.89205222
50	cellular glucuronidation (GO:0052695)	2.88411009
51	drug catabolic process (GO:0042737)	2.88368920
52	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.87474219
53	vitamin biosynthetic process (GO:0009110)	2.86392469
54	glycine metabolic process (GO:0006544)	2.82800248
55	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.81799736
56	branched-chain amino acid catabolic process (GO:0009083)	2.80826890
57	indole-containing compound catabolic process (GO:0042436)	2.80686563
58	indolalkylamine catabolic process (GO:0046218)	2.80686563
59	tryptophan catabolic process (GO:0006569)	2.80686563
60	GTP biosynthetic process (GO:0006183)	2.80533839
61	DNA damage response, detection of DNA damage (GO:0042769)	2.79372402
62	tetrahydrofolate metabolic process (GO:0046653)	2.78962858
63	omega-hydroxylase P450 pathway (GO:0097267)	2.78176495
64	regulation of glucokinase activity (GO:0033131)	2.78074094
65	regulation of hexokinase activity (GO:1903299)	2.78074094
66	ribosome assembly (GO:0042255)	2.77854978
67	negative regulation of ligase activity (GO:0051352)	2.77735876
68	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.77735876
69	epoxygenase P450 pathway (GO:0019373)	2.77057283
70	serine family amino acid biosynthetic process (GO:0009070)	2.76221639
71	tRNA modification (GO:0006400)	2.75291178
72	regulation of mesoderm development (GO:2000380)	2.74893301
73	DNA replication checkpoint (GO:0000076)	2.74467275
74	tRNA processing (GO:0008033)	2.69576619
75	kidney morphogenesis (GO:0060993)	2.66581937
76	protein deneddylation (GO:0000338)	2.65280224
77	spliceosomal snRNP assembly (GO:0000387)	2.64113516
78	nucleobase biosynthetic process (GO:0046112)	2.63133556
79	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.60563684
80	inner mitochondrial membrane organization (GO:0007007)	2.58385882
81	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.57596777
82	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.57596777
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.57596777
84	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.55984274
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55150930
86	sterol biosynthetic process (GO:0016126)	2.54717623
87	DNA double-strand break processing (GO:0000729)	2.54578072
88	kynurenine metabolic process (GO:0070189)	2.52016292
89	L-serine metabolic process (GO:0006563)	2.51639173
90	tryptophan metabolic process (GO:0006568)	2.51352090
91	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.51189057
92	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.51189057
93	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.50695362
94	IMP biosynthetic process (GO:0006188)	2.49757479
95	GPI anchor biosynthetic process (GO:0006506)	2.49010628
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.48713163
97	spliceosomal complex assembly (GO:0000245)	2.48516303
98	urate metabolic process (GO:0046415)	2.48042746
99	isotype switching (GO:0045190)	2.47027550
100	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.47027550

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.59916074
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94359448
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56779144
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.39624143
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.06080497
6	E2F7_22180533_ChIP-Seq_HELA_Human	2.96374017
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80639191
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.66331584
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56796442
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49891563
11	FUS_26573619_Chip-Seq_HEK293_Human	2.41572290
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.35864887
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35076853
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.23914110
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.21468144
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.18617217
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.18065587
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17811190
19	VDR_22108803_ChIP-Seq_LS180_Human	2.13929043
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.10901476
21	EWS_26573619_Chip-Seq_HEK293_Human	2.08364871
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03896065
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.96232622
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95924765
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.91943293
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.90786037
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.86255460
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.86014155
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85730720
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80880546
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.72008510
32	P300_19829295_ChIP-Seq_ESCs_Human	1.70953348
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.69428766
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64002336
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.57962266
36	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.54974262
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53954631
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.51793760
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50096147
40	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.48234652
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.48071723
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.47968205
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.47287952
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46550600
45	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.44707693
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44140665
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.43062332
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.42917577
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42642670
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.41806091
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.41490323
52	IGF1R_20145208_ChIP-Seq_DFB_Human	1.39439792
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39217605
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36154901
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34535489
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34535489
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32877736
58	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.28828706
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28471111
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24830963
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.24115331
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.20778642
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.19097772
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.17900092
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.15501393
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.14879102
67	AR_20517297_ChIP-Seq_VCAP_Human	1.13209878
68	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.13044670
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11258856
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11258856
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.10186957
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.10056325
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09251079
74	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.03805990
75	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.03612420
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02848780
77	GABP_19822575_ChIP-Seq_HepG2_Human	1.01574852
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01157656
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00524126
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00445628
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00347818
82	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99963875
83	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99653300
84	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96639159
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95201778
86	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.94234151
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.93916921
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.92784897
89	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92142569
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90924748
91	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90287324
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90248896
93	CBP_20019798_ChIP-Seq_JUKART_Human	0.90051471
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90051471
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.89058339
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.88974252
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.88196519
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.87310746
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.86996797
100	NCOR_22424771_ChIP-Seq_293T_Human	0.86853011

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.76665844
2	MP0003806_abnormal_nucleotide_metabolis	3.74300637
3	MP0003195_calcinosis	3.51289641
4	MP0008875_abnormal_xenobiotic_pharmacok	3.11104110
5	MP0003252_abnormal_bile_duct	3.05501213
6	MP0005084_abnormal_gallbladder_morpholo	2.99324494
7	MP0002102_abnormal_ear_morphology	2.83165261
8	MP0005085_abnormal_gallbladder_physiolo	2.82713093
9	MP0003693_abnormal_embryo_hatching	2.80711428
10	MP0008058_abnormal_DNA_repair	2.67042549
11	MP0003011_delayed_dark_adaptation	2.63077069
12	MP0006292_abnormal_olfactory_placode	2.61651298
13	MP0005365_abnormal_bile_salt	2.29283801
14	MP0006072_abnormal_retinal_apoptosis	2.19704268
15	MP0003136_yellow_coat_color	2.14817675
16	MP0002138_abnormal_hepatobiliary_system	2.11806017
17	MP0002938_white_spotting	2.03622362
18	MP0001293_anophthalmia	1.92584482
19	MP0003941_abnormal_skin_development	1.92519989
20	MP0003186_abnormal_redox_activity	1.87490164
21	MP0001764_abnormal_homeostasis	1.85340047
22	MP0002837_dystrophic_cardiac_calcinosis	1.81609225
23	MP0006036_abnormal_mitochondrial_physio	1.68313080
24	MP0000372_irregular_coat_pigmentation	1.67060519
25	MP0010094_abnormal_chromosome_stability	1.66688221
26	MP0005332_abnormal_amino_acid	1.66443949
27	MP0004133_heterotaxia	1.65972636
28	MP0001666_abnormal_nutrient_absorption	1.65403940
29	MP0002928_abnormal_bile_duct	1.57918310
30	MP0003718_maternal_effect	1.57035826
31	MP0003283_abnormal_digestive_organ	1.56910247
32	MP0008007_abnormal_cellular_replicative	1.49597269
33	MP0005551_abnormal_eye_electrophysiolog	1.45979118
34	MP0003122_maternal_imprinting	1.45910927
35	MP0009697_abnormal_copulation	1.39268033
36	MP0001485_abnormal_pinna_reflex	1.37562901
37	MP0002653_abnormal_ependyma_morphology	1.36557861
38	MP0001984_abnormal_olfaction	1.34736681
39	MP0002090_abnormal_vision	1.34678149
40	MP0005379_endocrine/exocrine_gland_phen	1.31080263
41	MP0010329_abnormal_lipoprotein_level	1.23012549
42	MP0005410_abnormal_fertilization	1.22482273
43	MP0004957_abnormal_blastocyst_morpholog	1.19419759
44	MP0005253_abnormal_eye_physiology	1.18340437
45	MP0002277_abnormal_respiratory_mucosa	1.16756978
46	MP0006035_abnormal_mitochondrial_morpho	1.14302839
47	MP0003567_abnormal_fetal_cardiomyocyte	1.13758270
48	MP0001986_abnormal_taste_sensitivity	1.13239678
49	MP0004019_abnormal_vitamin_homeostasis	1.11453342
50	MP0003890_abnormal_embryonic-extraembry	1.06880083
51	MP0008872_abnormal_physiological_respon	1.05669993
52	MP0005671_abnormal_response_to	1.02365205
53	MP0009384_cardiac_valve_regurgitation	1.01410083
54	MP0008932_abnormal_embryonic_tissue	0.99719124
55	MP0001324_abnormal_eye_pigmentation	0.97113271
56	MP0009764_decreased_sensitivity_to	0.93843318
57	MP0003786_premature_aging	0.93377351
58	MP0005075_abnormal_melanosome_morpholog	0.92002449
59	MP0001286_abnormal_eye_development	0.91332466
60	MP0002282_abnormal_trachea_morphology	0.91025873
61	MP0003937_abnormal_limbs/digits/tail_de	0.89275545
62	MP0005395_other_phenotype	0.88880996
63	MP0005646_abnormal_pituitary_gland	0.88716048
64	MP0005391_vision/eye_phenotype	0.88035667
65	MP0005389_reproductive_system_phenotype	0.87243347
66	MP0005319_abnormal_enzyme/_coenzyme	0.86213427
67	MP0005360_urolithiasis	0.85436677
68	MP0002160_abnormal_reproductive_system	0.84915160
69	MP0003077_abnormal_cell_cycle	0.84414279
70	MP0003638_abnormal_response/metabolism_	0.83084065
71	MP0004142_abnormal_muscle_tone	0.82841059
72	MP0003121_genomic_imprinting	0.79639529
73	MP0001929_abnormal_gametogenesis	0.78506651
74	MP0003646_muscle_fatigue	0.78190666
75	MP0004147_increased_porphyrin_level	0.78010361
76	MP0005408_hypopigmentation	0.76658045
77	MP0008877_abnormal_DNA_methylation	0.76437719
78	MP0000609_abnormal_liver_physiology	0.76015457
79	MP0005220_abnormal_exocrine_pancreas	0.75577193
80	MP0002163_abnormal_gland_morphology	0.74016858
81	MP0001529_abnormal_vocalization	0.72507640
82	MP0002233_abnormal_nose_morphology	0.71548221
83	MP0005636_abnormal_mineral_homeostasis	0.71150977
84	MP0002736_abnormal_nociception_after	0.71099923
85	MP0005174_abnormal_tail_pigmentation	0.70086972
86	MP0003868_abnormal_feces_composition	0.69726235
87	MP0009785_altered_susceptibility_to	0.69695643
88	MP0001919_abnormal_reproductive_system	0.68564047
89	MP0005195_abnormal_posterior_eye	0.65411835
90	MP0005167_abnormal_blood-brain_barrier	0.64528924
91	MP0001119_abnormal_female_reproductive	0.63473587
92	MP0000653_abnormal_sex_gland	0.62593079
93	MP0003943_abnormal_hepatobiliary_system	0.61934860
94	MP0002638_abnormal_pupillary_reflex	0.61596723
95	MP0006276_abnormal_autonomic_nervous	0.61024602
96	MP0003878_abnormal_ear_physiology	0.59015225
97	MP0005377_hearing/vestibular/ear_phenot	0.59015225
98	MP0003111_abnormal_nucleus_morphology	0.58911580
99	MP0003172_abnormal_lysosome_physiology	0.58362545
100	MP0005266_abnormal_metabolism	0.57129681

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of methionine metabolism (HP:0010901)	4.11967535
2	Increased hepatocellular lipid droplets (HP:0006565)	3.80990261
3	Lipid accumulation in hepatocytes (HP:0006561)	3.56408343
4	Methylmalonic acidemia (HP:0002912)	3.47852934
5	Acute necrotizing encephalopathy (HP:0006965)	3.45922303
6	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.43446589
7	Acute encephalopathy (HP:0006846)	3.37990273
8	Renal Fanconi syndrome (HP:0001994)	3.32314848
9	Increased intramyocellular lipid droplets (HP:0012240)	3.22351211
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.19801462
11	Mitochondrial inheritance (HP:0001427)	3.15726236
12	Methylmalonic aciduria (HP:0012120)	3.13733353
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.11105806
14	Bile duct proliferation (HP:0001408)	3.09497637
15	Abnormal biliary tract physiology (HP:0012439)	3.09497637
16	Increased CSF lactate (HP:0002490)	3.09478218
17	Cerebral edema (HP:0002181)	3.06519727
18	Prolonged partial thromboplastin time (HP:0003645)	3.05410535
19	Hypobetalipoproteinemia (HP:0003563)	3.01986639
20	Progressive macrocephaly (HP:0004481)	3.01637683
21	Hyperglycinemia (HP:0002154)	2.95997994
22	Intrahepatic cholestasis (HP:0001406)	2.89558440
23	Generalized aminoaciduria (HP:0002909)	2.88245185
24	Spontaneous abortion (HP:0005268)	2.87339394
25	Pancreatic fibrosis (HP:0100732)	2.82394381
26	True hermaphroditism (HP:0010459)	2.80688764
27	Abnormality of serine family amino acid metabolism (HP:0010894)	2.78390071
28	Abnormality of glycine metabolism (HP:0010895)	2.78390071
29	Abnormality of urine glucose concentration (HP:0011016)	2.71735050
30	Glycosuria (HP:0003076)	2.71735050
31	Hyperglycinuria (HP:0003108)	2.70300167
32	Pancreatic cysts (HP:0001737)	2.67648851
33	Abolished electroretinogram (ERG) (HP:0000550)	2.65413066
34	Increased muscle lipid content (HP:0009058)	2.60114179
35	Supernumerary spleens (HP:0009799)	2.59068979
36	Reticulocytopenia (HP:0001896)	2.57634874
37	Abnormality of serum amino acid levels (HP:0003112)	2.56052443
38	Hepatic necrosis (HP:0002605)	2.52246520
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.52100826
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.52100826
41	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.50791171
42	Abnormality of vitamin B metabolism (HP:0004340)	2.49128892
43	Respiratory difficulties (HP:0002880)	2.47439493
44	Exertional dyspnea (HP:0002875)	2.45433239
45	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.43380866
46	Hepatocellular necrosis (HP:0001404)	2.40743182
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38671851
48	Lethargy (HP:0001254)	2.35352673
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.34384600
50	Absent/shortened dynein arms (HP:0200106)	2.34384600
51	Abnormality of midbrain morphology (HP:0002418)	2.33396892
52	Molar tooth sign on MRI (HP:0002419)	2.33396892
53	Medial flaring of the eyebrow (HP:0010747)	2.32040976
54	Type I transferrin isoform profile (HP:0003642)	2.31959293
55	Abnormality of renal resorption (HP:0011038)	2.26849067
56	Hypoglycemic coma (HP:0001325)	2.21852675
57	Increased serum lactate (HP:0002151)	2.21644198
58	Pancreatic islet-cell hyperplasia (HP:0004510)	2.21062366
59	Hyperphosphaturia (HP:0003109)	2.18110384
60	Duplicated collecting system (HP:0000081)	2.11226752
61	Dry hair (HP:0011359)	2.10453085
62	Renal cortical cysts (HP:0000803)	2.09987032
63	Abnormality of vitamin metabolism (HP:0100508)	2.08912701
64	Macrocytic anemia (HP:0001972)	2.07940846
65	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.07884708
66	Dicarboxylic aciduria (HP:0003215)	2.07884708
67	Abnormality of pyrimidine metabolism (HP:0004353)	2.07432151
68	Meckel diverticulum (HP:0002245)	2.03218140
69	Lactic acidosis (HP:0003128)	2.02603219
70	Pancytopenia (HP:0001876)	2.02174538
71	Reduced antithrombin III activity (HP:0001976)	1.98500465
72	Abnormality of the renal collecting system (HP:0004742)	1.96258455
73	Abnormality of the ileum (HP:0001549)	1.95210606
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.94570882
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94016436
76	Congenital stationary night blindness (HP:0007642)	1.93120515
77	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.91876167
78	Short hallux (HP:0010109)	1.91441973
79	Large for gestational age (HP:0001520)	1.91266484
80	3-Methylglutaconic aciduria (HP:0003535)	1.89920539
81	Asplenia (HP:0001746)	1.89447346
82	Increased serum pyruvate (HP:0003542)	1.88543931
83	Abnormal rod and cone electroretinograms (HP:0008323)	1.88043021
84	Abnormality of the renal cortex (HP:0011035)	1.87177200
85	Aplastic anemia (HP:0001915)	1.87008534
86	Megaloblastic anemia (HP:0001889)	1.85403227
87	Nephronophthisis (HP:0000090)	1.82048180
88	Abnormal protein glycosylation (HP:0012346)	1.81891331
89	Abnormal glycosylation (HP:0012345)	1.81891331
90	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81891331
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.81891331
92	Nausea (HP:0002018)	1.81704301
93	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.81583403
94	Congenital, generalized hypertrichosis (HP:0004540)	1.81388096
95	Complement deficiency (HP:0004431)	1.80994809
96	Optic disc pallor (HP:0000543)	1.78918134
97	Abnormality of the labia minora (HP:0012880)	1.78645593
98	Septo-optic dysplasia (HP:0100842)	1.78170965
99	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76067325
100	Hyperalaninemia (HP:0003348)	1.76067325

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	3.00643233
2	TSSK6	2.94217343
3	WNK3	2.88945175
4	CDC7	2.56313485
5	PBK	2.38517121
6	TIE1	2.37450894
7	VRK2	2.32982275
8	BMPR1B	2.30641296
9	EIF2AK3	2.28405063
10	MAP3K9	2.28213889
11	GRK1	2.26622113
12	WEE1	2.19602737
13	PNCK	2.14367318
14	ZAK	2.13294990
15	MAPK15	2.07845314
16	TAF1	2.05753781
17	NUAK1	2.04784135
18	TAOK3	2.03863046
19	PLK3	1.94565318
20	STK16	1.94206587
21	VRK1	1.91733805
22	MKNK2	1.91482116
23	ADRBK2	1.90786783
24	FRK	1.88621522
25	MKNK1	1.87910725
26	BUB1	1.87283126
27	PLK4	1.81656874
28	MST4	1.77849889
29	EIF2AK1	1.70357072
30	BCKDK	1.69234501
31	BRSK2	1.67663975
32	TGFBR1	1.50665928
33	PASK	1.27063133
34	PINK1	1.25569468
35	MAP3K4	1.23836690
36	CDK3	1.20663700
37	TEC	1.19519511
38	IRAK1	1.12929083
39	SRPK1	1.07787522
40	TRIM28	1.05200976
41	PDK2	1.02385918
42	WNK4	0.91794386
43	TNIK	0.90088653
44	CSNK1G1	0.89453685
45	NEK1	0.89009577
46	GRK7	0.87433637
47	MAP4K2	0.83681391
48	TTK	0.80038914
49	TXK	0.78818660
50	TLK1	0.77200062
51	PLK1	0.74348085
52	CSNK1G2	0.73450383
53	SCYL2	0.69831503
54	IRAK2	0.67706773
55	STK38L	0.64484975
56	CCNB1	0.64341338
57	FLT3	0.61489807
58	DYRK2	0.60927562
59	ALK	0.60548713
60	STK39	0.59970942
61	CSNK1G3	0.59696326
62	MAPKAPK3	0.58922935
63	EIF2AK2	0.58742049
64	MATK	0.58323332
65	ITK	0.57559779
66	CSNK2A1	0.55263093
67	STK24	0.54492819
68	FGFR1	0.54393221
69	PRKCG	0.53534504
70	ADRBK1	0.53301158
71	MAP2K7	0.52823616
72	CSF1R	0.52691909
73	CASK	0.51012881
74	CHEK2	0.50747079
75	KIT	0.49792925
76	NLK	0.49560781
77	CSNK2A2	0.48919280
78	LATS1	0.43169755
79	IGF1R	0.41716141
80	ATM	0.41592581
81	IRAK4	0.41462646
82	OXSR1	0.41291885
83	FER	0.40139094
84	IKBKE	0.39354060
85	AURKB	0.39180170
86	INSRR	0.38205462
87	PRKCE	0.37526558
88	FGFR2	0.36963551
89	CDK19	0.35833998
90	ERBB3	0.34366902
91	PIK3CA	0.32620925
92	PRKCQ	0.32562114
93	PLK2	0.32190845
94	IKBKB	0.32155864
95	KDR	0.32113461
96	TESK2	0.29590147
97	PAK3	0.29038000
98	STK3	0.28459406
99	DAPK1	0.27393499
100	ATR	0.26446416

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.20711730
2	Caffeine metabolism_Homo sapiens_hsa00232	2.61068837
3	Propanoate metabolism_Homo sapiens_hsa00640	2.50305344
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43650260
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.43617593
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42275079
7	Ribosome_Homo sapiens_hsa03010	2.37406674
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.25358416
9	Protein export_Homo sapiens_hsa03060	2.17663657
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.08453250
11	Parkinsons disease_Homo sapiens_hsa05012	2.06852055
12	One carbon pool by folate_Homo sapiens_hsa00670	2.01891787
13	Butanoate metabolism_Homo sapiens_hsa00650	1.97974035
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.94462051
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.93658244
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.89780786
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.89612705
18	Retinol metabolism_Homo sapiens_hsa00830	1.88368061
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.86882650
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79459515
21	Fatty acid degradation_Homo sapiens_hsa00071	1.68875674
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66896351
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.64975546
24	Mismatch repair_Homo sapiens_hsa03430	1.63829611
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.59261795
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.58692554
27	Homologous recombination_Homo sapiens_hsa03440	1.57355233
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.57071070
29	Basal transcription factors_Homo sapiens_hsa03022	1.56207773
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.45275461
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.45226122
32	Peroxisome_Homo sapiens_hsa04146	1.44127087
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.40089289
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39510546
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39418168
36	RNA polymerase_Homo sapiens_hsa03020	1.39207456
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.38580020
38	DNA replication_Homo sapiens_hsa03030	1.37076547
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.34221404
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.33220902
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27987693
42	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.27658010
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26708050
44	Huntingtons disease_Homo sapiens_hsa05016	1.23317576
45	RNA degradation_Homo sapiens_hsa03018	1.22969872
46	Fatty acid elongation_Homo sapiens_hsa00062	1.22543298
47	Selenocompound metabolism_Homo sapiens_hsa00450	1.21998369
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18872789
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17515477
50	Glutathione metabolism_Homo sapiens_hsa00480	1.13013071
51	Sulfur metabolism_Homo sapiens_hsa00920	1.12226544
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.10290870
53	Folate biosynthesis_Homo sapiens_hsa00790	1.09976832
54	Spliceosome_Homo sapiens_hsa03040	1.04686836
55	Alzheimers disease_Homo sapiens_hsa05010	1.04315002
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.98982668
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93324103
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.93130382
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92845598
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.92021591
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91838797
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90710331
63	RNA transport_Homo sapiens_hsa03013	0.90210349
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.89684577
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.87418863
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.85599615
67	Metabolic pathways_Homo sapiens_hsa01100	0.83363274
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.82917615
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81667343
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80921798
71	Purine metabolism_Homo sapiens_hsa00230	0.80894229
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77461083
73	Sulfur relay system_Homo sapiens_hsa04122	0.65106806
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.59835960
75	Carbon metabolism_Homo sapiens_hsa01200	0.57733630
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56913995
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56043251
78	PPAR signaling pathway_Homo sapiens_hsa03320	0.55153566
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54352342
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53797137
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49879680
82	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48106601
83	Histidine metabolism_Homo sapiens_hsa00340	0.46684614
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.46379603
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.45717122
86	Base excision repair_Homo sapiens_hsa03410	0.43361983
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43112490
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42091795
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.40980997
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39232173
91	Phototransduction_Homo sapiens_hsa04744	0.38284772
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37111966
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36369232
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.31348098
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29291543
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28876618
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.28614021
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.27840320
99	Bile secretion_Homo sapiens_hsa04976	0.27316924
100	Mineral absorption_Homo sapiens_hsa04978	0.26894030

FAM35BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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