FAM35BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.62082087
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.39625389
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25283579
4protein neddylation (GO:0045116)4.20868743
5proteasome assembly (GO:0043248)4.18383471
6pseudouridine synthesis (GO:0001522)3.93285720
7chaperone-mediated protein transport (GO:0072321)3.91938952
8exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.90619206
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.90113491
10ATP synthesis coupled proton transport (GO:0015986)3.86023906
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86023906
12respiratory chain complex IV assembly (GO:0008535)3.78246543
13S-adenosylmethionine metabolic process (GO:0046500)3.75021479
14mitochondrial respiratory chain complex assembly (GO:0033108)3.55014037
15protein complex biogenesis (GO:0070271)3.50541925
16chromatin remodeling at centromere (GO:0031055)3.50507558
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43226001
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41475904
19L-phenylalanine catabolic process (GO:0006559)3.41475904
20regulation of activation of Janus kinase activity (GO:0010533)3.36062860
21CENP-A containing nucleosome assembly (GO:0034080)3.33777402
22ribosomal large subunit biogenesis (GO:0042273)3.31319018
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.27180627
24NADH dehydrogenase complex assembly (GO:0010257)3.27180627
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27180627
26L-phenylalanine metabolic process (GO:0006558)3.27008636
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27008636
28glyoxylate metabolic process (GO:0046487)3.24780830
29purine nucleobase biosynthetic process (GO:0009113)3.23892110
30cytochrome complex assembly (GO:0017004)3.21683261
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20040277
32xenobiotic catabolic process (GO:0042178)3.16603510
33exogenous drug catabolic process (GO:0042738)3.15139189
34response to nitrosative stress (GO:0051409)3.13161634
35aromatic amino acid family catabolic process (GO:0009074)3.09293312
36DNA deamination (GO:0045006)3.07719088
37uronic acid metabolic process (GO:0006063)3.05297393
38glucuronate metabolic process (GO:0019585)3.05297393
39respiratory electron transport chain (GO:0022904)3.02736493
40electron transport chain (GO:0022900)3.00489753
41bile acid biosynthetic process (GO:0006699)2.93735454
42cullin deneddylation (GO:0010388)2.93486054
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92805805
44regulation of cellular amino acid metabolic process (GO:0006521)2.91951776
45platelet dense granule organization (GO:0060155)2.90405992
46histone exchange (GO:0043486)2.90258091
47protein-cofactor linkage (GO:0018065)2.89849774
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89588346
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89205222
50cellular glucuronidation (GO:0052695)2.88411009
51drug catabolic process (GO:0042737)2.88368920
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87474219
53vitamin biosynthetic process (GO:0009110)2.86392469
54glycine metabolic process (GO:0006544)2.82800248
55negative regulation of DNA-dependent DNA replication (GO:2000104)2.81799736
56branched-chain amino acid catabolic process (GO:0009083)2.80826890
57indole-containing compound catabolic process (GO:0042436)2.80686563
58indolalkylamine catabolic process (GO:0046218)2.80686563
59tryptophan catabolic process (GO:0006569)2.80686563
60GTP biosynthetic process (GO:0006183)2.80533839
61DNA damage response, detection of DNA damage (GO:0042769)2.79372402
62tetrahydrofolate metabolic process (GO:0046653)2.78962858
63omega-hydroxylase P450 pathway (GO:0097267)2.78176495
64regulation of glucokinase activity (GO:0033131)2.78074094
65regulation of hexokinase activity (GO:1903299)2.78074094
66ribosome assembly (GO:0042255)2.77854978
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77735876
68negative regulation of ligase activity (GO:0051352)2.77735876
69epoxygenase P450 pathway (GO:0019373)2.77057283
70serine family amino acid biosynthetic process (GO:0009070)2.76221639
71tRNA modification (GO:0006400)2.75291178
72regulation of mesoderm development (GO:2000380)2.74893301
73DNA replication checkpoint (GO:0000076)2.74467275
74tRNA processing (GO:0008033)2.69576619
75kidney morphogenesis (GO:0060993)2.66581937
76protein deneddylation (GO:0000338)2.65280224
77spliceosomal snRNP assembly (GO:0000387)2.64113516
78nucleobase biosynthetic process (GO:0046112)2.63133556
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60563684
80inner mitochondrial membrane organization (GO:0007007)2.58385882
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57596777
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57596777
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57596777
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55984274
85preassembly of GPI anchor in ER membrane (GO:0016254)2.55150930
86sterol biosynthetic process (GO:0016126)2.54717623
87DNA double-strand break processing (GO:0000729)2.54578072
88kynurenine metabolic process (GO:0070189)2.52016292
89L-serine metabolic process (GO:0006563)2.51639173
90tryptophan metabolic process (GO:0006568)2.51352090
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51189057
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51189057
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.50695362
94IMP biosynthetic process (GO:0006188)2.49757479
95GPI anchor biosynthetic process (GO:0006506)2.49010628
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.48713163
97spliceosomal complex assembly (GO:0000245)2.48516303
98urate metabolic process (GO:0046415)2.48042746
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47027550
100isotype switching (GO:0045190)2.47027550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59916074
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94359448
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.56779144
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.39624143
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06080497
6E2F7_22180533_ChIP-Seq_HELA_Human2.96374017
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80639191
8ELK1_19687146_ChIP-ChIP_HELA_Human2.66331584
9ZNF274_21170338_ChIP-Seq_K562_Hela2.56796442
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.49891563
11FUS_26573619_Chip-Seq_HEK293_Human2.41572290
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35864887
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35076853
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23914110
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21468144
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.18617217
17VDR_23849224_ChIP-Seq_CD4+_Human2.18065587
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.17811190
19VDR_22108803_ChIP-Seq_LS180_Human2.13929043
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10901476
21EWS_26573619_Chip-Seq_HEK293_Human2.08364871
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.03896065
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96232622
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95924765
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91943293
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90786037
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86255460
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86014155
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.85730720
30FOXP3_21729870_ChIP-Seq_TREG_Human1.80880546
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72008510
32P300_19829295_ChIP-Seq_ESCs_Human1.70953348
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69428766
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.64002336
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57962266
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54974262
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53954631
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51793760
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50096147
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48234652
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48071723
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47968205
43MYC_18940864_ChIP-ChIP_HL60_Human1.47287952
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46550600
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44707693
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44140665
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43062332
48TAF15_26573619_Chip-Seq_HEK293_Human1.42917577
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.42642670
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.41806091
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41490323
52IGF1R_20145208_ChIP-Seq_DFB_Human1.39439792
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39217605
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36154901
55NANOG_19829295_ChIP-Seq_ESCs_Human1.34535489
56SOX2_19829295_ChIP-Seq_ESCs_Human1.34535489
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32877736
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.28828706
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28471111
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24830963
61DCP1A_22483619_ChIP-Seq_HELA_Human1.24115331
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20778642
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19097772
64TCF4_22108803_ChIP-Seq_LS180_Human1.17900092
65BCAT_22108803_ChIP-Seq_LS180_Human1.15501393
66TTF2_22483619_ChIP-Seq_HELA_Human1.14879102
67AR_20517297_ChIP-Seq_VCAP_Human1.13209878
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13044670
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.11258856
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11258856
71GBX2_23144817_ChIP-Seq_PC3_Human1.10186957
72ER_23166858_ChIP-Seq_MCF-7_Human1.10056325
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09251079
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03805990
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03612420
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.02848780
77GABP_19822575_ChIP-Seq_HepG2_Human1.01574852
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01157656
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00524126
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00445628
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00347818
82IRF1_19129219_ChIP-ChIP_H3396_Human0.99963875
83CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99653300
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.96639159
85HTT_18923047_ChIP-ChIP_STHdh_Human0.95201778
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94234151
87TP53_22573176_ChIP-Seq_HFKS_Human0.93916921
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92784897
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92142569
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.90924748
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90287324
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90248896
93CBP_20019798_ChIP-Seq_JUKART_Human0.90051471
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90051471
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89058339
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88974252
97ERG_20517297_ChIP-Seq_VCAP_Human0.88196519
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87310746
99CDX2_22108803_ChIP-Seq_LS180_Human0.86996797
100NCOR_22424771_ChIP-Seq_293T_Human0.86853011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.76665844
2MP0003806_abnormal_nucleotide_metabolis3.74300637
3MP0003195_calcinosis3.51289641
4MP0008875_abnormal_xenobiotic_pharmacok3.11104110
5MP0003252_abnormal_bile_duct3.05501213
6MP0005084_abnormal_gallbladder_morpholo2.99324494
7MP0002102_abnormal_ear_morphology2.83165261
8MP0005085_abnormal_gallbladder_physiolo2.82713093
9MP0003693_abnormal_embryo_hatching2.80711428
10MP0008058_abnormal_DNA_repair2.67042549
11MP0003011_delayed_dark_adaptation2.63077069
12MP0006292_abnormal_olfactory_placode2.61651298
13MP0005365_abnormal_bile_salt2.29283801
14MP0006072_abnormal_retinal_apoptosis2.19704268
15MP0003136_yellow_coat_color2.14817675
16MP0002138_abnormal_hepatobiliary_system2.11806017
17MP0002938_white_spotting2.03622362
18MP0001293_anophthalmia1.92584482
19MP0003941_abnormal_skin_development1.92519989
20MP0003186_abnormal_redox_activity1.87490164
21MP0001764_abnormal_homeostasis1.85340047
22MP0002837_dystrophic_cardiac_calcinosis1.81609225
23MP0006036_abnormal_mitochondrial_physio1.68313080
24MP0000372_irregular_coat_pigmentation1.67060519
25MP0010094_abnormal_chromosome_stability1.66688221
26MP0005332_abnormal_amino_acid1.66443949
27MP0004133_heterotaxia1.65972636
28MP0001666_abnormal_nutrient_absorption1.65403940
29MP0002928_abnormal_bile_duct1.57918310
30MP0003718_maternal_effect1.57035826
31MP0003283_abnormal_digestive_organ1.56910247
32MP0008007_abnormal_cellular_replicative1.49597269
33MP0005551_abnormal_eye_electrophysiolog1.45979118
34MP0003122_maternal_imprinting1.45910927
35MP0009697_abnormal_copulation1.39268033
36MP0001485_abnormal_pinna_reflex1.37562901
37MP0002653_abnormal_ependyma_morphology1.36557861
38MP0001984_abnormal_olfaction1.34736681
39MP0002090_abnormal_vision1.34678149
40MP0005379_endocrine/exocrine_gland_phen1.31080263
41MP0010329_abnormal_lipoprotein_level1.23012549
42MP0005410_abnormal_fertilization1.22482273
43MP0004957_abnormal_blastocyst_morpholog1.19419759
44MP0005253_abnormal_eye_physiology1.18340437
45MP0002277_abnormal_respiratory_mucosa1.16756978
46MP0006035_abnormal_mitochondrial_morpho1.14302839
47MP0003567_abnormal_fetal_cardiomyocyte1.13758270
48MP0001986_abnormal_taste_sensitivity1.13239678
49MP0004019_abnormal_vitamin_homeostasis1.11453342
50MP0003890_abnormal_embryonic-extraembry1.06880083
51MP0008872_abnormal_physiological_respon1.05669993
52MP0005671_abnormal_response_to1.02365205
53MP0009384_cardiac_valve_regurgitation1.01410083
54MP0008932_abnormal_embryonic_tissue0.99719124
55MP0001324_abnormal_eye_pigmentation0.97113271
56MP0009764_decreased_sensitivity_to0.93843318
57MP0003786_premature_aging0.93377351
58MP0005075_abnormal_melanosome_morpholog0.92002449
59MP0001286_abnormal_eye_development0.91332466
60MP0002282_abnormal_trachea_morphology0.91025873
61MP0003937_abnormal_limbs/digits/tail_de0.89275545
62MP0005395_other_phenotype0.88880996
63MP0005646_abnormal_pituitary_gland0.88716048
64MP0005391_vision/eye_phenotype0.88035667
65MP0005389_reproductive_system_phenotype0.87243347
66MP0005319_abnormal_enzyme/_coenzyme0.86213427
67MP0005360_urolithiasis0.85436677
68MP0002160_abnormal_reproductive_system0.84915160
69MP0003077_abnormal_cell_cycle0.84414279
70MP0003638_abnormal_response/metabolism_0.83084065
71MP0004142_abnormal_muscle_tone0.82841059
72MP0003121_genomic_imprinting0.79639529
73MP0001929_abnormal_gametogenesis0.78506651
74MP0003646_muscle_fatigue0.78190666
75MP0004147_increased_porphyrin_level0.78010361
76MP0005408_hypopigmentation0.76658045
77MP0008877_abnormal_DNA_methylation0.76437719
78MP0000609_abnormal_liver_physiology0.76015457
79MP0005220_abnormal_exocrine_pancreas0.75577193
80MP0002163_abnormal_gland_morphology0.74016858
81MP0001529_abnormal_vocalization0.72507640
82MP0002233_abnormal_nose_morphology0.71548221
83MP0005636_abnormal_mineral_homeostasis0.71150977
84MP0002736_abnormal_nociception_after0.71099923
85MP0005174_abnormal_tail_pigmentation0.70086972
86MP0003868_abnormal_feces_composition0.69726235
87MP0009785_altered_susceptibility_to0.69695643
88MP0001919_abnormal_reproductive_system0.68564047
89MP0005195_abnormal_posterior_eye0.65411835
90MP0005167_abnormal_blood-brain_barrier0.64528924
91MP0001119_abnormal_female_reproductive0.63473587
92MP0000653_abnormal_sex_gland0.62593079
93MP0003943_abnormal_hepatobiliary_system0.61934860
94MP0002638_abnormal_pupillary_reflex0.61596723
95MP0006276_abnormal_autonomic_nervous0.61024602
96MP0003878_abnormal_ear_physiology0.59015225
97MP0005377_hearing/vestibular/ear_phenot0.59015225
98MP0003111_abnormal_nucleus_morphology0.58911580
99MP0003172_abnormal_lysosome_physiology0.58362545
100MP0005266_abnormal_metabolism0.57129681

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of methionine metabolism (HP:0010901)4.11967535
2Increased hepatocellular lipid droplets (HP:0006565)3.80990261
3Lipid accumulation in hepatocytes (HP:0006561)3.56408343
4Methylmalonic acidemia (HP:0002912)3.47852934
5Acute necrotizing encephalopathy (HP:0006965)3.45922303
6Abnormality of aspartate family amino acid metabolism (HP:0010899)3.43446589
7Acute encephalopathy (HP:0006846)3.37990273
8Renal Fanconi syndrome (HP:0001994)3.32314848
9Increased intramyocellular lipid droplets (HP:0012240)3.22351211
10Abnormal mitochondria in muscle tissue (HP:0008316)3.19801462
11Mitochondrial inheritance (HP:0001427)3.15726236
12Methylmalonic aciduria (HP:0012120)3.13733353
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11105806
14Abnormal biliary tract physiology (HP:0012439)3.09497637
15Bile duct proliferation (HP:0001408)3.09497637
16Increased CSF lactate (HP:0002490)3.09478218
17Cerebral edema (HP:0002181)3.06519727
18Prolonged partial thromboplastin time (HP:0003645)3.05410535
19Hypobetalipoproteinemia (HP:0003563)3.01986639
20Progressive macrocephaly (HP:0004481)3.01637683
21Hyperglycinemia (HP:0002154)2.95997994
22Intrahepatic cholestasis (HP:0001406)2.89558440
23Generalized aminoaciduria (HP:0002909)2.88245185
24Spontaneous abortion (HP:0005268)2.87339394
25Pancreatic fibrosis (HP:0100732)2.82394381
26True hermaphroditism (HP:0010459)2.80688764
27Abnormality of glycine metabolism (HP:0010895)2.78390071
28Abnormality of serine family amino acid metabolism (HP:0010894)2.78390071
29Glycosuria (HP:0003076)2.71735050
30Abnormality of urine glucose concentration (HP:0011016)2.71735050
31Hyperglycinuria (HP:0003108)2.70300167
32Pancreatic cysts (HP:0001737)2.67648851
33Abolished electroretinogram (ERG) (HP:0000550)2.65413066
34Increased muscle lipid content (HP:0009058)2.60114179
35Supernumerary spleens (HP:0009799)2.59068979
36Reticulocytopenia (HP:0001896)2.57634874
37Abnormality of serum amino acid levels (HP:0003112)2.56052443
38Hepatic necrosis (HP:0002605)2.52246520
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52100826
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52100826
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.50791171
42Abnormality of vitamin B metabolism (HP:0004340)2.49128892
43Respiratory difficulties (HP:0002880)2.47439493
44Exertional dyspnea (HP:0002875)2.45433239
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.43380866
46Hepatocellular necrosis (HP:0001404)2.40743182
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38671851
48Lethargy (HP:0001254)2.35352673
49Absent/shortened dynein arms (HP:0200106)2.34384600
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.34384600
51Abnormality of midbrain morphology (HP:0002418)2.33396892
52Molar tooth sign on MRI (HP:0002419)2.33396892
53Medial flaring of the eyebrow (HP:0010747)2.32040976
54Type I transferrin isoform profile (HP:0003642)2.31959293
55Abnormality of renal resorption (HP:0011038)2.26849067
56Hypoglycemic coma (HP:0001325)2.21852675
57Increased serum lactate (HP:0002151)2.21644198
58Pancreatic islet-cell hyperplasia (HP:0004510)2.21062366
59Hyperphosphaturia (HP:0003109)2.18110384
60Duplicated collecting system (HP:0000081)2.11226752
61Dry hair (HP:0011359)2.10453085
62Renal cortical cysts (HP:0000803)2.09987032
63Abnormality of vitamin metabolism (HP:0100508)2.08912701
64Macrocytic anemia (HP:0001972)2.07940846
65Dicarboxylic aciduria (HP:0003215)2.07884708
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07884708
67Abnormality of pyrimidine metabolism (HP:0004353)2.07432151
68Meckel diverticulum (HP:0002245)2.03218140
69Lactic acidosis (HP:0003128)2.02603219
70Pancytopenia (HP:0001876)2.02174538
71Reduced antithrombin III activity (HP:0001976)1.98500465
72Abnormality of the renal collecting system (HP:0004742)1.96258455
73Abnormality of the ileum (HP:0001549)1.95210606
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.94570882
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94016436
76Congenital stationary night blindness (HP:0007642)1.93120515
77Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91876167
78Short hallux (HP:0010109)1.91441973
79Large for gestational age (HP:0001520)1.91266484
803-Methylglutaconic aciduria (HP:0003535)1.89920539
81Asplenia (HP:0001746)1.89447346
82Increased serum pyruvate (HP:0003542)1.88543931
83Abnormal rod and cone electroretinograms (HP:0008323)1.88043021
84Abnormality of the renal cortex (HP:0011035)1.87177200
85Aplastic anemia (HP:0001915)1.87008534
86Megaloblastic anemia (HP:0001889)1.85403227
87Nephronophthisis (HP:0000090)1.82048180
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81891331
89Abnormal protein N-linked glycosylation (HP:0012347)1.81891331
90Abnormal protein glycosylation (HP:0012346)1.81891331
91Abnormal glycosylation (HP:0012345)1.81891331
92Nausea (HP:0002018)1.81704301
93Aplasia/Hypoplasia of the hallux (HP:0008362)1.81583403
94Congenital, generalized hypertrichosis (HP:0004540)1.81388096
95Complement deficiency (HP:0004431)1.80994809
96Optic disc pallor (HP:0000543)1.78918134
97Abnormality of the labia minora (HP:0012880)1.78645593
98Septo-optic dysplasia (HP:0100842)1.78170965
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76067325
100Hyperalaninemia (HP:0003348)1.76067325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.00643233
2TSSK62.94217343
3WNK32.88945175
4CDC72.56313485
5PBK2.38517121
6TIE12.37450894
7VRK22.32982275
8BMPR1B2.30641296
9EIF2AK32.28405063
10MAP3K92.28213889
11GRK12.26622113
12WEE12.19602737
13PNCK2.14367318
14ZAK2.13294990
15MAPK152.07845314
16TAF12.05753781
17NUAK12.04784135
18TAOK32.03863046
19PLK31.94565318
20STK161.94206587
21VRK11.91733805
22MKNK21.91482116
23ADRBK21.90786783
24FRK1.88621522
25MKNK11.87910725
26BUB11.87283126
27PLK41.81656874
28MST41.77849889
29EIF2AK11.70357072
30BCKDK1.69234501
31BRSK21.67663975
32TGFBR11.50665928
33PASK1.27063133
34PINK11.25569468
35MAP3K41.23836690
36CDK31.20663700
37TEC1.19519511
38IRAK11.12929083
39SRPK11.07787522
40TRIM281.05200976
41PDK21.02385918
42WNK40.91794386
43TNIK0.90088653
44CSNK1G10.89453685
45NEK10.89009577
46GRK70.87433637
47MAP4K20.83681391
48TTK0.80038914
49TXK0.78818660
50TLK10.77200062
51PLK10.74348085
52CSNK1G20.73450383
53SCYL20.69831503
54IRAK20.67706773
55STK38L0.64484975
56CCNB10.64341338
57FLT30.61489807
58DYRK20.60927562
59ALK0.60548713
60STK390.59970942
61CSNK1G30.59696326
62MAPKAPK30.58922935
63EIF2AK20.58742049
64MATK0.58323332
65ITK0.57559779
66CSNK2A10.55263093
67STK240.54492819
68FGFR10.54393221
69PRKCG0.53534504
70ADRBK10.53301158
71MAP2K70.52823616
72CSF1R0.52691909
73CASK0.51012881
74CHEK20.50747079
75KIT0.49792925
76NLK0.49560781
77CSNK2A20.48919280
78LATS10.43169755
79IGF1R0.41716141
80ATM0.41592581
81IRAK40.41462646
82OXSR10.41291885
83FER0.40139094
84IKBKE0.39354060
85AURKB0.39180170
86INSRR0.38205462
87PRKCE0.37526558
88FGFR20.36963551
89CDK190.35833998
90ERBB30.34366902
91PIK3CA0.32620925
92PRKCQ0.32562114
93PLK20.32190845
94IKBKB0.32155864
95KDR0.32113461
96TESK20.29590147
97PAK30.29038000
98STK30.28459406
99DAPK10.27393499
100ATR0.26446416

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.20711730
2Caffeine metabolism_Homo sapiens_hsa002322.61068837
3Propanoate metabolism_Homo sapiens_hsa006402.50305344
4Oxidative phosphorylation_Homo sapiens_hsa001902.43650260
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.43617593
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42275079
7Ribosome_Homo sapiens_hsa030102.37406674
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25358416
9Protein export_Homo sapiens_hsa030602.17663657
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08453250
11Parkinsons disease_Homo sapiens_hsa050122.06852055
12One carbon pool by folate_Homo sapiens_hsa006702.01891787
13Butanoate metabolism_Homo sapiens_hsa006501.97974035
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94462051
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93658244
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89780786
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89612705
18Retinol metabolism_Homo sapiens_hsa008301.88368061
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86882650
20Chemical carcinogenesis_Homo sapiens_hsa052041.79459515
21Fatty acid degradation_Homo sapiens_hsa000711.68875674
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66896351
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64975546
24Mismatch repair_Homo sapiens_hsa034301.63829611
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59261795
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58692554
27Homologous recombination_Homo sapiens_hsa034401.57355233
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.57071070
29Basal transcription factors_Homo sapiens_hsa030221.56207773
30Tryptophan metabolism_Homo sapiens_hsa003801.45275461
31Complement and coagulation cascades_Homo sapiens_hsa046101.45226122
32Peroxisome_Homo sapiens_hsa041461.44127087
33Steroid biosynthesis_Homo sapiens_hsa001001.40089289
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.39510546
35Fanconi anemia pathway_Homo sapiens_hsa034601.39418168
36RNA polymerase_Homo sapiens_hsa030201.39207456
37Nitrogen metabolism_Homo sapiens_hsa009101.38580020
38DNA replication_Homo sapiens_hsa030301.37076547
39Pyruvate metabolism_Homo sapiens_hsa006201.34221404
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.33220902
41Linoleic acid metabolism_Homo sapiens_hsa005911.27987693
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27658010
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26708050
44Huntingtons disease_Homo sapiens_hsa050161.23317576
45RNA degradation_Homo sapiens_hsa030181.22969872
46Fatty acid elongation_Homo sapiens_hsa000621.22543298
47Selenocompound metabolism_Homo sapiens_hsa004501.21998369
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.18872789
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17515477
50Glutathione metabolism_Homo sapiens_hsa004801.13013071
51Sulfur metabolism_Homo sapiens_hsa009201.12226544
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10290870
53Folate biosynthesis_Homo sapiens_hsa007901.09976832
54Spliceosome_Homo sapiens_hsa030401.04686836
55Alzheimers disease_Homo sapiens_hsa050101.04315002
56Nucleotide excision repair_Homo sapiens_hsa034200.98982668
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93324103
58Fatty acid metabolism_Homo sapiens_hsa012120.93130382
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92845598
60Arginine biosynthesis_Homo sapiens_hsa002200.92021591
61Vitamin B6 metabolism_Homo sapiens_hsa007500.91838797
62Pyrimidine metabolism_Homo sapiens_hsa002400.90710331
63RNA transport_Homo sapiens_hsa030130.90210349
64Fat digestion and absorption_Homo sapiens_hsa049750.89684577
65Non-homologous end-joining_Homo sapiens_hsa034500.87418863
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85599615
67Metabolic pathways_Homo sapiens_hsa011000.83363274
68Tyrosine metabolism_Homo sapiens_hsa003500.82917615
69Vitamin digestion and absorption_Homo sapiens_hsa049770.81667343
70beta-Alanine metabolism_Homo sapiens_hsa004100.80921798
71Purine metabolism_Homo sapiens_hsa002300.80894229
72Arachidonic acid metabolism_Homo sapiens_hsa005900.77461083
73Sulfur relay system_Homo sapiens_hsa041220.65106806
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59835960
75Carbon metabolism_Homo sapiens_hsa012000.57733630
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56913995
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56043251
78PPAR signaling pathway_Homo sapiens_hsa033200.55153566
79Cardiac muscle contraction_Homo sapiens_hsa042600.54352342
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53797137
81Starch and sucrose metabolism_Homo sapiens_hsa005000.49879680
82Biosynthesis of amino acids_Homo sapiens_hsa012300.48106601
83Histidine metabolism_Homo sapiens_hsa003400.46684614
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46379603
85Primary immunodeficiency_Homo sapiens_hsa053400.45717122
86Base excision repair_Homo sapiens_hsa034100.43361983
87N-Glycan biosynthesis_Homo sapiens_hsa005100.43112490
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42091795
89Staphylococcus aureus infection_Homo sapiens_hsa051500.40980997
90Phenylalanine metabolism_Homo sapiens_hsa003600.39232173
91Phototransduction_Homo sapiens_hsa047440.38284772
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37111966
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36369232
94Antigen processing and presentation_Homo sapiens_hsa046120.31348098
95Collecting duct acid secretion_Homo sapiens_hsa049660.29291543
96Rheumatoid arthritis_Homo sapiens_hsa053230.28876618
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.28614021
98Ether lipid metabolism_Homo sapiens_hsa005650.27840320
99Bile secretion_Homo sapiens_hsa049760.27316924
100Mineral absorption_Homo sapiens_hsa049780.26894030

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