FAM35CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)8.25318299
2cilium movement (GO:0003341)7.05644198
3axonemal dynein complex assembly (GO:0070286)5.98888653
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26380200
5cilium or flagellum-dependent cell motility (GO:0001539)4.94293399
6protein localization to cilium (GO:0061512)4.85435406
7presynaptic membrane assembly (GO:0097105)4.79199607
8GTP biosynthetic process (GO:0006183)4.77153916
9pantothenate metabolic process (GO:0015939)4.60951871
10coenzyme A biosynthetic process (GO:0015937)4.47493845
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42272474
12ATP synthesis coupled proton transport (GO:0015986)4.42272474
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40858654
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.31320852
15nucleoside diphosphate phosphorylation (GO:0006165)4.29760577
16platelet dense granule organization (GO:0060155)4.21311636
17ADP metabolic process (GO:0046031)4.20331150
18intraciliary transport (GO:0042073)4.16457113
19postsynaptic membrane organization (GO:0001941)4.15164424
20negative regulation of osteoblast proliferation (GO:0033689)4.00436371
21protein neddylation (GO:0045116)3.95588607
22protein K6-linked ubiquitination (GO:0085020)3.90023558
23UTP biosynthetic process (GO:0006228)3.83430606
24presynaptic membrane organization (GO:0097090)3.76433075
25positive regulation of cellular amide metabolic process (GO:0034250)3.73668554
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.71957191
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.64861185
28positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.63396656
29axoneme assembly (GO:0035082)3.62222158
30intra-S DNA damage checkpoint (GO:0031573)3.61680676
31motile cilium assembly (GO:0044458)3.61113111
32respiratory electron transport chain (GO:0022904)3.56709648
33electron transport chain (GO:0022900)3.56109097
34cell fate commitment involved in formation of primary germ layer (GO:0060795)3.52209441
35proteasome assembly (GO:0043248)3.49717756
36regulation of beta-amyloid formation (GO:1902003)3.47261590
37UTP metabolic process (GO:0046051)3.46452163
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44233918
39organelle disassembly (GO:1903008)3.36063146
40DNA double-strand break processing (GO:0000729)3.33807321
41male meiosis I (GO:0007141)3.26799678
42guanosine-containing compound biosynthetic process (GO:1901070)3.24760725
43cobalamin metabolic process (GO:0009235)3.17582836
44coenzyme A metabolic process (GO:0015936)3.14921484
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14294495
46cilium organization (GO:0044782)3.12208837
47lymph node development (GO:0048535)3.11065112
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10759665
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10759665
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09939652
51cilium morphogenesis (GO:0060271)3.07990533
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05842775
53dopamine transport (GO:0015872)3.01604934
54sequestering of actin monomers (GO:0042989)3.00981531
55DNA deamination (GO:0045006)2.99498505
56cilium assembly (GO:0042384)2.99441728
57growth hormone receptor signaling pathway (GO:0060396)2.98621586
58regulation of respiratory system process (GO:0044065)2.97406068
59SMAD protein complex assembly (GO:0007183)2.95766014
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.95290398
61auditory receptor cell stereocilium organization (GO:0060088)2.93903041
62response to misfolded protein (GO:0051788)2.88284607
63neuron cell-cell adhesion (GO:0007158)2.87165291
64CTP biosynthetic process (GO:0006241)2.83902056
65CTP metabolic process (GO:0046036)2.83902056
66ventricular system development (GO:0021591)2.80479636
67positive regulation of developmental pigmentation (GO:0048087)2.80402072
68interferon-gamma production (GO:0032609)2.80219439
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79498061
70GPI anchor metabolic process (GO:0006505)2.78908253
71cellular response to growth hormone stimulus (GO:0071378)2.76895393
72smoothened signaling pathway (GO:0007224)2.73951859
73regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73918578
74positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73918578
75negative regulation of Ras GTPase activity (GO:0034261)2.73851373
76auditory behavior (GO:0031223)2.73663953
77GPI anchor biosynthetic process (GO:0006506)2.71721292
78positive regulation of response to oxidative stress (GO:1902884)2.71430692
79positive regulation of cellular response to oxidative stress (GO:1900409)2.71430692
80regulation of inositol phosphate biosynthetic process (GO:0010919)2.70112887
81regulation of vacuole organization (GO:0044088)2.68840282
82positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67926332
83Golgi to endosome transport (GO:0006895)2.65261201
84histone mRNA metabolic process (GO:0008334)2.63526339
85regulation of mRNA 3-end processing (GO:0031440)2.62889997
86ATP biosynthetic process (GO:0006754)2.62865205
87female gonad development (GO:0008585)2.62773681
88positive regulation of interleukin-17 production (GO:0032740)2.58841678
89cell differentiation involved in metanephros development (GO:0072202)2.57629315
90nucleotide phosphorylation (GO:0046939)2.56303809
91nucleoside triphosphate biosynthetic process (GO:0009142)2.55719673
92regulation of pigment cell differentiation (GO:0050932)2.55144372
93neurotransmitter-gated ion channel clustering (GO:0072578)2.55125072
94mechanosensory behavior (GO:0007638)2.54536751
95positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.54278720
96hydrogen transport (GO:0006818)2.53130720
97AMP metabolic process (GO:0046033)2.52038948
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.51320779
99cytoplasmic mRNA processing body assembly (GO:0033962)2.51242488
100DNA catabolic process, exonucleolytic (GO:0000738)2.50527302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26217083
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.48511377
3VDR_22108803_ChIP-Seq_LS180_Human3.14090629
4ZNF274_21170338_ChIP-Seq_K562_Hela2.81321833
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.70590827
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.70002845
7GATA1_22025678_ChIP-Seq_K562_Human2.63377561
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52686269
9IGF1R_20145208_ChIP-Seq_DFB_Human2.51271136
10FUS_26573619_Chip-Seq_HEK293_Human2.49057404
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40667539
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37827107
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32730860
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28760918
15IRF1_19129219_ChIP-ChIP_H3396_Human2.25535577
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.24097154
17EWS_26573619_Chip-Seq_HEK293_Human2.21746393
18ER_23166858_ChIP-Seq_MCF-7_Human2.12920243
19TAF15_26573619_Chip-Seq_HEK293_Human2.09992076
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05204949
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04132506
22VDR_23849224_ChIP-Seq_CD4+_Human2.01489140
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00279741
24P300_19829295_ChIP-Seq_ESCs_Human1.97769604
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85110363
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66134234
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.64918301
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63663566
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62815334
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62673568
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61585974
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.58890703
33GBX2_23144817_ChIP-Seq_PC3_Human1.58664409
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58369427
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56561336
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51542767
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51542767
38ELK1_19687146_ChIP-ChIP_HELA_Human1.50320111
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49945663
40SCL_19346495_ChIP-Seq_HPC-7_Human1.49937252
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49040563
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.47739010
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46894611
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43250025
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41957460
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40505162
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38116810
48SMAD4_21799915_ChIP-Seq_A2780_Human1.38032905
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.37002271
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35506212
51BCAT_22108803_ChIP-Seq_LS180_Human1.35131040
52TCF4_22108803_ChIP-Seq_LS180_Human1.34031839
53AR_25329375_ChIP-Seq_VCAP_Human1.32615544
54MYC_18940864_ChIP-ChIP_HL60_Human1.31601350
55RXR_22108803_ChIP-Seq_LS180_Human1.30011981
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28058754
57CBP_20019798_ChIP-Seq_JUKART_Human1.28058754
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23596624
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19659822
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17883594
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15314786
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14691124
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14554817
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.12613182
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.12334093
66SALL4_22934838_ChIP-ChIP_CD34+_Human1.12005133
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11742003
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11255546
69TP53_22573176_ChIP-Seq_HFKS_Human1.11125858
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10685133
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.10378093
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09621633
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.09459024
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.09201670
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.09128822
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.09053158
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.08645481
78P53_22387025_ChIP-Seq_ESCs_Mouse1.08550315
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.08517040
80NANOG_19829295_ChIP-Seq_ESCs_Human1.08061043
81SOX2_19829295_ChIP-Seq_ESCs_Human1.08061043
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07789581
83STAT3_23295773_ChIP-Seq_U87_Human1.07019355
84RNF2_27304074_Chip-Seq_NSC_Mouse1.06218764
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05191619
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04972144
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04274788
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04263299
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03805442
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.03619198
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03619198
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03381882
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02599502
94FOXH1_21741376_ChIP-Seq_EPCs_Human1.02470956
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02415356
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00954375
97GATA3_26560356_Chip-Seq_TH2_Human1.00377107
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98411752
99JUN_21703547_ChIP-Seq_K562_Human0.98410948
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97366112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.10965555
2MP0002138_abnormal_hepatobiliary_system5.03371224
3MP0003806_abnormal_nucleotide_metabolis4.51999808
4MP0003880_abnormal_central_pattern4.08600632
5MP0004145_abnormal_muscle_electrophysio3.54046153
6MP0000566_synostosis3.18078323
7MP0005670_abnormal_white_adipose3.00010799
8MP0004381_abnormal_hair_follicle2.79866066
9MP0003195_calcinosis2.65515263
10MP0005075_abnormal_melanosome_morpholog2.53260118
11MP0000685_abnormal_immune_system2.47306714
12MP0005084_abnormal_gallbladder_morpholo2.28774744
13MP0003787_abnormal_imprinting2.11248269
14MP0004885_abnormal_endolymph2.07960308
15MP0002938_white_spotting2.04097881
16MP0008058_abnormal_DNA_repair1.95474218
17MP0002638_abnormal_pupillary_reflex1.93895125
18MP0003878_abnormal_ear_physiology1.92048659
19MP0005377_hearing/vestibular/ear_phenot1.92048659
20MP0003693_abnormal_embryo_hatching1.80608693
21MP0006292_abnormal_olfactory_placode1.72902724
22MP0005253_abnormal_eye_physiology1.70456220
23MP0006072_abnormal_retinal_apoptosis1.65720937
24MP0006276_abnormal_autonomic_nervous1.62655927
25MP0004133_heterotaxia1.60748941
26MP0008877_abnormal_DNA_methylation1.59250762
27MP0010030_abnormal_orbit_morphology1.57892657
28MP0001666_abnormal_nutrient_absorption1.50937706
29MP0001835_abnormal_antigen_presentation1.48251101
30MP0000372_irregular_coat_pigmentation1.46570307
31MP0001984_abnormal_olfaction1.46489698
32MP0001324_abnormal_eye_pigmentation1.40908418
33MP0005646_abnormal_pituitary_gland1.39840459
34MP0000631_abnormal_neuroendocrine_gland1.33177626
35MP0005187_abnormal_penis_morphology1.28929015
36MP0001293_anophthalmia1.27626176
37MP0002102_abnormal_ear_morphology1.20877817
38MP0001968_abnormal_touch/_nociception1.17663075
39MP0002095_abnormal_skin_pigmentation1.17407847
40MP0005551_abnormal_eye_electrophysiolog1.15476312
41MP0005248_abnormal_Harderian_gland1.13589522
42MP0004142_abnormal_muscle_tone1.12398442
43MP0004019_abnormal_vitamin_homeostasis1.12335337
44MP0009765_abnormal_xenobiotic_induced1.10998248
45MP0003283_abnormal_digestive_organ1.10542321
46MP0008995_early_reproductive_senescence1.09656171
47MP0009046_muscle_twitch1.09017031
48MP0009785_altered_susceptibility_to1.02477703
49MP0001529_abnormal_vocalization1.02070371
50MP0002822_catalepsy1.01806294
51MP0002928_abnormal_bile_duct0.99329577
52MP0003937_abnormal_limbs/digits/tail_de0.97565167
53MP0002075_abnormal_coat/hair_pigmentati0.97249306
54MP0005408_hypopigmentation0.93436332
55MP0002735_abnormal_chemical_nociception0.92110449
56MP0002736_abnormal_nociception_after0.89448455
57MP0001485_abnormal_pinna_reflex0.85290313
58MP0002148_abnormal_hypersensitivity_rea0.82407550
59MP0003121_genomic_imprinting0.82211563
60MP0005085_abnormal_gallbladder_physiolo0.81852951
61MP0000427_abnormal_hair_cycle0.81520703
62MP0001790_abnormal_immune_system0.80902788
63MP0005387_immune_system_phenotype0.80902788
64MP0001905_abnormal_dopamine_level0.76027095
65MP0001800_abnormal_humoral_immune0.73936446
66MP0003936_abnormal_reproductive_system0.72434175
67MP0005195_abnormal_posterior_eye0.72347790
68MP0005197_abnormal_uvea_morphology0.71574677
69MP0005671_abnormal_response_to0.71314822
70MP0001486_abnormal_startle_reflex0.70470215
71MP0003868_abnormal_feces_composition0.69272231
72MP0003303_peritoneal_inflammation0.69038066
73MP0001727_abnormal_embryo_implantation0.68439255
74MP0002734_abnormal_mechanical_nocicepti0.68052082
75MP0000537_abnormal_urethra_morphology0.67893557
76MP0005391_vision/eye_phenotype0.67015721
77MP0004883_abnormal_blood_vessel0.65802389
78MP0002452_abnormal_antigen_presenting0.65657356
79MP0001286_abnormal_eye_development0.65626280
80MP0005171_absent_coat_pigmentation0.64972096
81MP0005379_endocrine/exocrine_gland_phen0.64856448
82MP0009745_abnormal_behavioral_response0.63585200
83MP0008789_abnormal_olfactory_epithelium0.63054276
84MP0002909_abnormal_adrenal_gland0.63003992
85MP0005332_abnormal_amino_acid0.62790355
86MP0003786_premature_aging0.60822617
87MP0000647_abnormal_sebaceous_gland0.60218849
88MP0000026_abnormal_inner_ear0.59852836
89MP0000569_abnormal_digit_pigmentation0.58981490
90MP0009764_decreased_sensitivity_to0.58735798
91MP0001346_abnormal_lacrimal_gland0.58663888
92MP0001186_pigmentation_phenotype0.58337010
93MP0008872_abnormal_physiological_respon0.58099769
94MP0002282_abnormal_trachea_morphology0.57604873
95MP0005499_abnormal_olfactory_system0.55429430
96MP0005394_taste/olfaction_phenotype0.55429430
97MP0002272_abnormal_nervous_system0.55009784
98MP0001958_emphysema0.53967723
99MP0004215_abnormal_myocardial_fiber0.49982331
100MP0003646_muscle_fatigue0.49714485

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)4.76404377
23-Methylglutaconic aciduria (HP:0003535)4.46355758
3Abnormal ciliary motility (HP:0012262)4.41061171
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.33718294
5Molar tooth sign on MRI (HP:0002419)4.32276894
6Abnormality of midbrain morphology (HP:0002418)4.32276894
7Short tibia (HP:0005736)3.95882921
8Abnormality of homocysteine metabolism (HP:0010919)3.90488314
9Homocystinuria (HP:0002156)3.90488314
10Rhinitis (HP:0012384)3.86438456
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.82997781
12Abnormality of methionine metabolism (HP:0010901)3.67799814
13Pancreatic fibrosis (HP:0100732)3.67583309
14Pancreatic cysts (HP:0001737)3.67439456
15Abnormal respiratory motile cilium morphology (HP:0005938)3.59700793
16Abnormal respiratory epithelium morphology (HP:0012253)3.59700793
17Increased hepatocellular lipid droplets (HP:0006565)3.56496209
18Short 4th metacarpal (HP:0010044)3.45637962
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.45637962
20True hermaphroditism (HP:0010459)3.44118760
21Abolished electroretinogram (ERG) (HP:0000550)3.39538406
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.38516991
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.38516991
24Lipid accumulation in hepatocytes (HP:0006561)3.32603224
25Nephronophthisis (HP:0000090)3.01909260
26Bifid tongue (HP:0010297)2.96264396
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95369758
28Absent/shortened dynein arms (HP:0200106)2.94050602
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.94050602
30Chronic bronchitis (HP:0004469)2.81668902
31Abnormality of the 4th metacarpal (HP:0010012)2.81370686
32Metaphyseal dysplasia (HP:0100255)2.77324586
33Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.76209637
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.70145754
35Renal Fanconi syndrome (HP:0001994)2.68123813
36Short phalanx of the thumb (HP:0009660)2.62757701
37Mitochondrial inheritance (HP:0001427)2.59215819
38Thyroiditis (HP:0100646)2.49464909
39Medial flaring of the eyebrow (HP:0010747)2.48276065
40Abnormality of the corticospinal tract (HP:0002492)2.43356766
41Bronchiectasis (HP:0002110)2.42261541
42Stomach cancer (HP:0012126)2.40781079
43Abnormality of vitamin B metabolism (HP:0004340)2.39148309
44Aplasia/hypoplasia of the uterus (HP:0008684)2.37365603
45Exertional dyspnea (HP:0002875)2.36529713
46Median cleft lip (HP:0000161)2.34904327
47Microvesicular hepatic steatosis (HP:0001414)2.33880832
48Increased CSF lactate (HP:0002490)2.24967895
49Abnormality of the renal medulla (HP:0100957)2.23360148
50Cystic liver disease (HP:0006706)2.21477751
51Severe combined immunodeficiency (HP:0004430)2.20167834
52Reticulocytopenia (HP:0001896)2.15980411
53Constricted visual fields (HP:0001133)2.14211502
54Chronic sinusitis (HP:0011109)2.12862457
55Preaxial hand polydactyly (HP:0001177)2.11451070
56Neoplasm of the heart (HP:0100544)2.11123285
57Congenital hepatic fibrosis (HP:0002612)2.07163114
58Stomatitis (HP:0010280)2.06851583
59Fibular hypoplasia (HP:0003038)2.06738265
60Progressive macrocephaly (HP:0004481)2.05505253
61Aplastic anemia (HP:0001915)2.05193053
62Medulloblastoma (HP:0002885)2.04562423
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.04515595
64Congenital, generalized hypertrichosis (HP:0004540)2.04264233
65Split foot (HP:0001839)2.04007257
66Chronic otitis media (HP:0000389)2.03241737
67Abnormality of the anterior horn cell (HP:0006802)2.02811836
68Degeneration of anterior horn cells (HP:0002398)2.02811836
69Chronic hepatic failure (HP:0100626)2.02736768
70Abnormality of macular pigmentation (HP:0008002)2.01790186
71Megaloblastic anemia (HP:0001889)1.97442339
72Male pseudohermaphroditism (HP:0000037)1.95104424
73Postaxial foot polydactyly (HP:0001830)1.93989573
74Acute necrotizing encephalopathy (HP:0006965)1.90734424
75Facial diplegia (HP:0001349)1.90669679
76Humeroradial synostosis (HP:0003041)1.89439881
77Synostosis involving the elbow (HP:0003938)1.89439881
78Abnormal biliary tract physiology (HP:0012439)1.89207366
79Bile duct proliferation (HP:0001408)1.89207366
80Anencephaly (HP:0002323)1.87732377
81Bony spicule pigmentary retinopathy (HP:0007737)1.87500121
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87139780
83Abnormality of the middle phalanges of the toes (HP:0010183)1.86833315
84Increased intramyocellular lipid droplets (HP:0012240)1.86661849
85Acute encephalopathy (HP:0006846)1.86599966
86Genital tract atresia (HP:0001827)1.83282631
87Abnormality of DNA repair (HP:0003254)1.82905467
88Furrowed tongue (HP:0000221)1.82445563
89Aplasia/Hypoplasia of the fibula (HP:0006492)1.82041305
90Oculomotor apraxia (HP:0000657)1.81059263
91Abnormal sex determination (HP:0012244)1.78185561
92Sex reversal (HP:0012245)1.78185561
93Attenuation of retinal blood vessels (HP:0007843)1.78105036
94Stenosis of the external auditory canal (HP:0000402)1.76368698
95Postaxial hand polydactyly (HP:0001162)1.74777144
96Methylmalonic acidemia (HP:0002912)1.73092648
97Bronchitis (HP:0012387)1.72881552
98Abnormality of urine glucose concentration (HP:0011016)1.70474827
99Glycosuria (HP:0003076)1.70474827
100Neoplasm of the oral cavity (HP:0100649)1.70248336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.89338089
2TLK14.92786536
3CDK84.30608677
4TGFBR13.61162544
5TRIM283.48465860
6NUAK13.37648901
7CCNB13.09218425
8FRK2.56259229
9TXK2.32292595
10SRPK11.97182404
11MAP4K21.87254839
12MKNK21.75052050
13TEC1.59781954
14BLK1.59412612
15FGFR21.51766690
16PINK11.51646543
17MKNK11.50537158
18RPS6KA41.49878745
19MAP3K101.48168134
20EPHA31.45103019
21EIF2AK31.45019340
22WNK31.40744259
23BCKDK1.36336898
24GRK11.33562988
25RPS6KA51.32046674
26ZAK1.21039721
27STK161.11587787
28VRK11.11302205
29PASK1.08132720
30ITK1.07089862
31DYRK21.04045251
32ERBB31.02855673
33CDK30.99831407
34STK240.98123905
35CDK90.97738180
36CDK190.96584584
37INSRR0.90586800
38MAPK150.87815355
39IRAK10.87495734
40MUSK0.84235764
41CASK0.79318314
42ILK0.79066501
43NEK90.76613591
44DYRK30.75989994
45TSSK60.74393496
46PIK3CA0.72359389
47EIF2AK10.70528078
48PTK2B0.67959660
49MAP2K70.67699855
50PLK30.67652006
51OBSCN0.67419584
52MAP3K40.66057593
53PRKCE0.65466649
54IKBKE0.64519288
55NLK0.63786949
56SYK0.59673628
57CHUK0.58610452
58MAPK130.54454609
59FGFR30.53603771
60MARK30.49823997
61ADRBK20.48910109
62MYLK0.48699845
63CSNK1G10.48620759
64BCR0.47677969
65CAMK2A0.46040712
66MAP3K120.46031218
67YES10.45712008
68PKN10.42563784
69LYN0.40696839
70CSNK1G20.38930785
71BTK0.38809642
72KDR0.38291829
73FGFR10.37891412
74TIE10.36492323
75PIK3CG0.36308571
76NTRK20.36273541
77VRK20.35756833
78SGK4940.35439471
79SGK2230.35439471
80PAK30.35062569
81IRAK40.34935992
82LCK0.34183753
83EIF2AK20.32464113
84MAPKAPK30.32462895
85OXSR10.32193466
86CSNK1A10.31728983
87IKBKB0.31480475
88PRKG10.29852877
89PLK20.29337189
90PRKACA0.28987494
91EGFR0.28941440
92DYRK1A0.28892477
93FES0.27538461
94TNIK0.27355490
95CSNK1G30.27146165
96NTRK30.26824790
97PRKCG0.26541415
98MAPK70.25749904
99CAMK10.25569494
100MAPKAPK50.25129975

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.89400575
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.58021618
3Proteasome_Homo sapiens_hsa030503.54801537
4Protein export_Homo sapiens_hsa030603.22353878
5Parkinsons disease_Homo sapiens_hsa050123.18613737
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67215017
7Asthma_Homo sapiens_hsa053102.40893796
8Huntingtons disease_Homo sapiens_hsa050162.36548426
9Homologous recombination_Homo sapiens_hsa034402.31089547
10Propanoate metabolism_Homo sapiens_hsa006402.30211385
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.27187042
12RNA polymerase_Homo sapiens_hsa030202.08567478
13Alzheimers disease_Homo sapiens_hsa050102.07289676
14Butanoate metabolism_Homo sapiens_hsa006502.02302049
15Ribosome_Homo sapiens_hsa030101.91321955
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82601227
17Systemic lupus erythematosus_Homo sapiens_hsa053221.79928435
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74416278
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73898792
20Basal cell carcinoma_Homo sapiens_hsa052171.73717534
21Allograft rejection_Homo sapiens_hsa053301.73569929
22Autoimmune thyroid disease_Homo sapiens_hsa053201.70050449
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68495864
24Graft-versus-host disease_Homo sapiens_hsa053321.67961764
25Nitrogen metabolism_Homo sapiens_hsa009101.66448432
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57879400
27Type I diabetes mellitus_Homo sapiens_hsa049401.56792012
28Hedgehog signaling pathway_Homo sapiens_hsa043401.53984252
29Collecting duct acid secretion_Homo sapiens_hsa049661.40940766
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39390347
31Fanconi anemia pathway_Homo sapiens_hsa034601.35606187
32Cardiac muscle contraction_Homo sapiens_hsa042601.33794361
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33633494
34Rheumatoid arthritis_Homo sapiens_hsa053231.27590585
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18076331
36Peroxisome_Homo sapiens_hsa041461.17568427
37RNA degradation_Homo sapiens_hsa030181.06727363
38Regulation of autophagy_Homo sapiens_hsa041401.04312933
39Nucleotide excision repair_Homo sapiens_hsa034201.04087292
40Purine metabolism_Homo sapiens_hsa002301.00399024
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99218954
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.91043818
43Staphylococcus aureus infection_Homo sapiens_hsa051500.90285434
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89128720
45Primary immunodeficiency_Homo sapiens_hsa053400.85900613
46Phototransduction_Homo sapiens_hsa047440.79596740
47Fat digestion and absorption_Homo sapiens_hsa049750.78771590
48Pyrimidine metabolism_Homo sapiens_hsa002400.78132645
49Dorso-ventral axis formation_Homo sapiens_hsa043200.77781097
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.74927933
51Mismatch repair_Homo sapiens_hsa034300.73258219
52Starch and sucrose metabolism_Homo sapiens_hsa005000.69089047
53Antigen processing and presentation_Homo sapiens_hsa046120.67114220
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66662316
55Glycerolipid metabolism_Homo sapiens_hsa005610.66586815
56Spliceosome_Homo sapiens_hsa030400.64029268
57Hematopoietic cell lineage_Homo sapiens_hsa046400.63280196
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62942596
59Steroid biosynthesis_Homo sapiens_hsa001000.61199152
60Epstein-Barr virus infection_Homo sapiens_hsa051690.60371699
61Selenocompound metabolism_Homo sapiens_hsa004500.58332605
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58117312
63Olfactory transduction_Homo sapiens_hsa047400.57816355
64Non-homologous end-joining_Homo sapiens_hsa034500.56865606
65Taste transduction_Homo sapiens_hsa047420.56839660
66Pyruvate metabolism_Homo sapiens_hsa006200.56384217
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55929236
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55893937
69Metabolic pathways_Homo sapiens_hsa011000.55010194
70Vitamin digestion and absorption_Homo sapiens_hsa049770.54256306
71Pancreatic secretion_Homo sapiens_hsa049720.54205669
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53926814
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53315624
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.53269909
75Alcoholism_Homo sapiens_hsa050340.52048442
76Nicotine addiction_Homo sapiens_hsa050330.51638740
77ABC transporters_Homo sapiens_hsa020100.51466144
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51403866
79RNA transport_Homo sapiens_hsa030130.49388915
80Chemical carcinogenesis_Homo sapiens_hsa052040.46097235
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44069318
82Leishmaniasis_Homo sapiens_hsa051400.41674072
83Basal transcription factors_Homo sapiens_hsa030220.40000886
84Tryptophan metabolism_Homo sapiens_hsa003800.39387180
85beta-Alanine metabolism_Homo sapiens_hsa004100.35748084
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.35094985
87TGF-beta signaling pathway_Homo sapiens_hsa043500.34702436
88Phagosome_Homo sapiens_hsa041450.34495540
89Carbon metabolism_Homo sapiens_hsa012000.30148425
90Morphine addiction_Homo sapiens_hsa050320.28805433
91Salivary secretion_Homo sapiens_hsa049700.27268021
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.27012581
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.26721713
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.25730354
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24639911
96Linoleic acid metabolism_Homo sapiens_hsa005910.24122524
97Glutathione metabolism_Homo sapiens_hsa004800.21859484
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21212951
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21089800
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19547545

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