ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.45434070
2	proteasome assembly (GO:0043248)	4.44999211
3	rRNA methylation (GO:0031167)	3.72959053
4	cullin deneddylation (GO:0010388)	3.71347834
5	rRNA modification (GO:0000154)	3.68078969
6	respiratory chain complex IV assembly (GO:0008535)	3.51791477
7	branched-chain amino acid catabolic process (GO:0009083)	3.45327870
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41995189
9	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39986491
10	inner mitochondrial membrane organization (GO:0007007)	3.38762588
11	sequestering of actin monomers (GO:0042989)	3.37632926
12	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.35472878
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35187617
14	ribosome assembly (GO:0042255)	3.26390157
15	protein complex biogenesis (GO:0070271)	3.26136522
16	vitamin biosynthetic process (GO:0009110)	3.24292954
17	response to nitrosative stress (GO:0051409)	3.23531494
18	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.22071387
19	protein deneddylation (GO:0000338)	3.20068344
20	mitochondrial RNA metabolic process (GO:0000959)	3.16212415
21	DNA damage response, detection of DNA damage (GO:0042769)	3.16153043
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14307254
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14307254
24	NADH dehydrogenase complex assembly (GO:0010257)	3.14307254
25	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.13680936
26	IMP biosynthetic process (GO:0006188)	3.12323078
27	GTP biosynthetic process (GO:0006183)	3.10478063
28	platelet dense granule organization (GO:0060155)	3.09716438
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.09589382
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.06852869
31	regulation of mitotic spindle checkpoint (GO:1903504)	3.05165815
32	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.05165815
33	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.03123284
34	protein neddylation (GO:0045116)	2.97627553
35	cytochrome complex assembly (GO:0017004)	2.96158992
36	purine nucleobase biosynthetic process (GO:0009113)	2.94449092
37	regulation of cellular amino acid metabolic process (GO:0006521)	2.94206117
38	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.92988658
39	isotype switching (GO:0045190)	2.92988658
40	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.92988658
41	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.92052880
42	negative regulation of ligase activity (GO:0051352)	2.92052880
43	chromatin remodeling at centromere (GO:0031055)	2.90294771
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89275143
45	drug catabolic process (GO:0042737)	2.88762754
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.87101358
47	lysine metabolic process (GO:0006553)	2.86974541
48	lysine catabolic process (GO:0006554)	2.86974541
49	bile acid biosynthetic process (GO:0006699)	2.82085007
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81074628
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81074628
52	IMP metabolic process (GO:0046040)	2.78961480
53	spliceosomal snRNP assembly (GO:0000387)	2.78755917
54	regulation of mitochondrial translation (GO:0070129)	2.77300574
55	nucleoside diphosphate phosphorylation (GO:0006165)	2.77062442
56	cholesterol biosynthetic process (GO:0006695)	2.76833288
57	ATP synthesis coupled proton transport (GO:0015986)	2.76039506
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.76039506
59	glucuronate metabolic process (GO:0019585)	2.74241793
60	uronic acid metabolic process (GO:0006063)	2.74241793
61	L-serine metabolic process (GO:0006563)	2.73178645
62	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73147121
63	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.71174945
64	branched-chain amino acid metabolic process (GO:0009081)	2.70815145
65	histone mRNA metabolic process (GO:0008334)	2.69038307
66	exogenous drug catabolic process (GO:0042738)	2.69017470
67	tRNA metabolic process (GO:0006399)	2.68491492
68	neural tube formation (GO:0001841)	2.67127651
69	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66277541
70	CENP-A containing nucleosome assembly (GO:0034080)	2.66205395
71	tRNA aminoacylation for protein translation (GO:0006418)	2.64626099
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.63082935
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.63082935
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.63082935
75	glyoxylate metabolic process (GO:0046487)	2.63020371
76	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.62860357
77	AMP metabolic process (GO:0046033)	2.62703440
78	protein-cofactor linkage (GO:0018065)	2.62101647
79	nucleobase biosynthetic process (GO:0046112)	2.60761173
80	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.59540338
81	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.59540338
82	tRNA aminoacylation (GO:0043039)	2.59405827
83	amino acid activation (GO:0043038)	2.59405827
84	intestinal cholesterol absorption (GO:0030299)	2.58945175
85	lactate metabolic process (GO:0006089)	2.58873670
86	pteridine-containing compound biosynthetic process (GO:0042559)	2.58473198
87	tryptophan metabolic process (GO:0006568)	2.57519140
88	sterol biosynthetic process (GO:0016126)	2.57371157
89	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.54626546
90	tRNA processing (GO:0008033)	2.54145239
91	dopamine transport (GO:0015872)	2.50883393
92	L-alpha-amino acid transmembrane transport (GO:1902475)	2.50573117
93	aldehyde catabolic process (GO:0046185)	2.50291425
94	cellular glucuronidation (GO:0052695)	2.50244408
95	C4-dicarboxylate transport (GO:0015740)	2.48902707
96	UTP metabolic process (GO:0046051)	2.48643134
97	indolalkylamine metabolic process (GO:0006586)	2.47519393
98	UTP biosynthetic process (GO:0006228)	2.47396690
99	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.46338419
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.46338419

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.25320737
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.46893460
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.44491402
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.20200824
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.01129398
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92762883
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63567570
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.59672731
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52026239
10	VDR_22108803_ChIP-Seq_LS180_Human	2.42559813
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.40310564
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.30767782
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20482420
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16596346
15	FUS_26573619_Chip-Seq_HEK293_Human	2.06712675
16	E2F7_22180533_ChIP-Seq_HELA_Human	2.04363717
17	EWS_26573619_Chip-Seq_HEK293_Human	1.99528548
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.98092709
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.96247945
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92132736
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.91821212
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.91475179
23	P300_19829295_ChIP-Seq_ESCs_Human	1.90803560
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.90556453
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.86644672
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.85844518
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79373308
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.75007829
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.71303786
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.70967375
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65047163
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.64655296
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64336406
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57415467
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.56851935
36	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56192103
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53878155
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53770201
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47764967
40	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.44314963
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44167391
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43735332
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41313685
44	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.40861583
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39946805
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.39387863
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35754148
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.34137124
49	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.33934157
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33070476
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31123892
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29183045
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29183045
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.28836358
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26154115
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.26123266
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.23797699
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.22969785
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21785502
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20569312
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19382414
62	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17539445
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.16801407
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16031235
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15765739
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15709534
67	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15295177
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14402452
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14402452
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13772230
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13485334
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.13145411
73	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.12850296
74	AR_21909140_ChIP-Seq_LNCAP_Human	1.12774951
75	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12380846
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11968442
77	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.10680929
78	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.10422998
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08464046
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07881501
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07520528
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05820193
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04966783
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04538765
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03902660
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03739916
87	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.03693456
88	AR_20517297_ChIP-Seq_VCAP_Human	1.03473089
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.02652942
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02543561
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01162494
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.00749472
93	CBP_20019798_ChIP-Seq_JUKART_Human	0.99697964
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99697964
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.98761054
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98503330
97	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98458509
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97863210
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.95673065
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.95662140

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.30949808
2	MP0008058_abnormal_DNA_repair	3.21735559
3	MP0005085_abnormal_gallbladder_physiolo	3.17263855
4	MP0002139_abnormal_hepatobiliary_system	2.98972162
5	MP0000372_irregular_coat_pigmentation	2.84939340
6	MP0000569_abnormal_digit_pigmentation	2.79572537
7	MP0006054_spinal_hemorrhage	2.74072559
8	MP0008875_abnormal_xenobiotic_pharmacok	2.69180885
9	MP0003693_abnormal_embryo_hatching	2.64875338
10	MP0003252_abnormal_bile_duct	2.64491970
11	MP0003806_abnormal_nucleotide_metabolis	2.47545790
12	MP0002102_abnormal_ear_morphology	2.35353178
13	MP0002254_reproductive_system_inflammat	2.34870891
14	MP0005365_abnormal_bile_salt	2.32669945
15	MP0005084_abnormal_gallbladder_morpholo	2.30933175
16	MP0003011_delayed_dark_adaptation	2.20247713
17	MP0003718_maternal_effect	2.18578264
18	MP0010094_abnormal_chromosome_stability	2.11267527
19	MP0005379_endocrine/exocrine_gland_phen	2.08062081
20	MP0001666_abnormal_nutrient_absorption	2.04288959
21	MP0001529_abnormal_vocalization	2.02074719
22	MP0005332_abnormal_amino_acid	1.92683907
23	MP0002163_abnormal_gland_morphology	1.86079653
24	MP0002938_white_spotting	1.84630649
25	MP0005551_abnormal_eye_electrophysiolog	1.79698671
26	MP0004133_heterotaxia	1.75685907
27	MP0006035_abnormal_mitochondrial_morpho	1.73533631
28	MP0003941_abnormal_skin_development	1.72450800
29	MP0003786_premature_aging	1.69807237
30	MP0001764_abnormal_homeostasis	1.63302501
31	MP0010329_abnormal_lipoprotein_level	1.58808066
32	MP0009697_abnormal_copulation	1.58246390
33	MP0006072_abnormal_retinal_apoptosis	1.54775640
34	MP0008995_early_reproductive_senescence	1.52275208
35	MP0005408_hypopigmentation	1.51363761
36	MP0006036_abnormal_mitochondrial_physio	1.47979057
37	MP0003186_abnormal_redox_activity	1.42625380
38	MP0002736_abnormal_nociception_after	1.38409223
39	MP0001293_anophthalmia	1.38336146
40	MP0001501_abnormal_sleep_pattern	1.37467069
41	MP0003880_abnormal_central_pattern	1.37294898
42	MP0004957_abnormal_blastocyst_morpholog	1.37206671
43	MP0006292_abnormal_olfactory_placode	1.34456877
44	MP0005647_abnormal_sex_gland	1.33881406
45	MP0001324_abnormal_eye_pigmentation	1.33563834
46	MP0002090_abnormal_vision	1.33194030
47	MP0004147_increased_porphyrin_level	1.32608480
48	MP0003122_maternal_imprinting	1.31575785
49	MP0005253_abnormal_eye_physiology	1.29536028
50	MP0004019_abnormal_vitamin_homeostasis	1.28939435
51	MP0000427_abnormal_hair_cycle	1.28115504
52	MP0006276_abnormal_autonomic_nervous	1.22119814
53	MP0000647_abnormal_sebaceous_gland	1.17906976
54	MP0003111_abnormal_nucleus_morphology	1.11650686
55	MP0005377_hearing/vestibular/ear_phenot	1.05657276
56	MP0003878_abnormal_ear_physiology	1.05657276
57	MP0000383_abnormal_hair_follicle	1.04633944
58	MP0003943_abnormal_hepatobiliary_system	1.00858690
59	MP0008932_abnormal_embryonic_tissue	1.00177624
60	MP0003136_yellow_coat_color	0.99035562
61	MP0005075_abnormal_melanosome_morpholog	0.96746841
62	MP0003077_abnormal_cell_cycle	0.95949962
63	MP0004142_abnormal_muscle_tone	0.95198343
64	MP0001485_abnormal_pinna_reflex	0.91446516
65	MP0002928_abnormal_bile_duct	0.91169766
66	MP0008877_abnormal_DNA_methylation	0.91123664
67	MP0001119_abnormal_female_reproductive	0.89449247
68	MP0003937_abnormal_limbs/digits/tail_de	0.88459152
69	MP0008872_abnormal_physiological_respon	0.83859788
70	MP0004742_abnormal_vestibular_system	0.83321537
71	MP0008007_abnormal_cellular_replicative	0.82351576
72	MP0005410_abnormal_fertilization	0.79061589
73	MP0003123_paternal_imprinting	0.78829273
74	MP0009764_decreased_sensitivity_to	0.78465802
75	MP0000371_diluted_coat_color	0.78447133
76	MP0005187_abnormal_penis_morphology	0.77516858
77	MP0002160_abnormal_reproductive_system	0.77382869
78	MP0005174_abnormal_tail_pigmentation	0.75718079
79	MP0005389_reproductive_system_phenotype	0.73768869
80	MP0003183_abnormal_peptide_metabolism	0.73666286
81	MP0005220_abnormal_exocrine_pancreas	0.73215285
82	MP0002233_abnormal_nose_morphology	0.71513162
83	MP0002138_abnormal_hepatobiliary_system	0.70639955
84	MP0005395_other_phenotype	0.69122013
85	MP0005310_abnormal_salivary_gland	0.68904682
86	MP0005646_abnormal_pituitary_gland	0.68581140
87	MP0005319_abnormal_enzyme/_coenzyme	0.68279507
88	MP0001177_atelectasis	0.68116710
89	MP0010386_abnormal_urinary_bladder	0.66811465
90	MP0000358_abnormal_cell_content/	0.65213238
91	MP0003121_genomic_imprinting	0.64953161
92	MP0002751_abnormal_autonomic_nervous	0.64621242
93	MP0000538_abnormal_urinary_bladder	0.64101759
94	MP0001286_abnormal_eye_development	0.63356595
95	MP0003868_abnormal_feces_composition	0.62457933
96	MP0000653_abnormal_sex_gland	0.61667342
97	MP0000598_abnormal_liver_morphology	0.60909599
98	MP0003567_abnormal_fetal_cardiomyocyte	0.60012202
99	MP0009672_abnormal_birth_weight	0.59865194
100	MP0000609_abnormal_liver_physiology	0.58493508

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.77692341
2	Lipid accumulation in hepatocytes (HP:0006561)	3.59970907
3	Abnormality of methionine metabolism (HP:0010901)	3.52663879
4	Hyperglycinemia (HP:0002154)	3.45980331
5	Increased serum pyruvate (HP:0003542)	3.26521163
6	Abnormality of serine family amino acid metabolism (HP:0010894)	3.18423985
7	Abnormality of glycine metabolism (HP:0010895)	3.18423985
8	Methylmalonic acidemia (HP:0002912)	3.15562328
9	Abnormality of serum amino acid levels (HP:0003112)	3.14343331
10	Prolonged partial thromboplastin time (HP:0003645)	3.12840587
11	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.03973488
12	Renal Fanconi syndrome (HP:0001994)	2.94047094
13	Hyperglycinuria (HP:0003108)	2.81914567
14	Acute encephalopathy (HP:0006846)	2.81423821
15	Abnormality of glycolysis (HP:0004366)	2.74387950
16	Pancreatic islet-cell hyperplasia (HP:0004510)	2.73220749
17	Increased CSF lactate (HP:0002490)	2.71849062
18	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.71769583
19	Hypoplasia of the fovea (HP:0007750)	2.71769583
20	Intrahepatic cholestasis (HP:0001406)	2.68797085
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68399867
22	Abnormality of alanine metabolism (HP:0010916)	2.68399867
23	Hyperalaninemia (HP:0003348)	2.68399867
24	Hypobetalipoproteinemia (HP:0003563)	2.62139289
25	Meckel diverticulum (HP:0002245)	2.61975741
26	Intestinal atresia (HP:0011100)	2.61644829
27	Abolished electroretinogram (ERG) (HP:0000550)	2.60188883
28	Abnormality of the fovea (HP:0000493)	2.59560763
29	Mitochondrial inheritance (HP:0001427)	2.55064319
30	Abnormality of the ileum (HP:0001549)	2.53866603
31	Methylmalonic aciduria (HP:0012120)	2.52041920
32	True hermaphroditism (HP:0010459)	2.51026061
33	Increased intramyocellular lipid droplets (HP:0012240)	2.47697181
34	Spontaneous abortion (HP:0005268)	2.46518836
35	Short tibia (HP:0005736)	2.44228317
36	Increased serum lactate (HP:0002151)	2.42307169
37	Generalized aminoaciduria (HP:0002909)	2.41246911
38	Abnormality of urine glucose concentration (HP:0011016)	2.39241538
39	Glycosuria (HP:0003076)	2.39241538
40	Supernumerary spleens (HP:0009799)	2.33321814
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32106105
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31486626
43	Hypothermia (HP:0002045)	2.30787514
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.29593573
45	Medial flaring of the eyebrow (HP:0010747)	2.27743992
46	Pancreatic cysts (HP:0001737)	2.27635279
47	Exertional dyspnea (HP:0002875)	2.26934885
48	Abnormality of vitamin B metabolism (HP:0004340)	2.26639215
49	Cerebral edema (HP:0002181)	2.26584419
50	Abnormality of the labia minora (HP:0012880)	2.25906436
51	Hepatocellular necrosis (HP:0001404)	2.25283977
52	Acute necrotizing encephalopathy (HP:0006965)	2.24702407
53	Hepatic necrosis (HP:0002605)	2.21725110
54	Reduced antithrombin III activity (HP:0001976)	2.18742982
55	Pancreatic fibrosis (HP:0100732)	2.18683793
56	Abnormality of chromosome stability (HP:0003220)	2.16756021
57	Type 2 muscle fiber atrophy (HP:0003554)	2.15881809
58	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.10867556
59	Lethargy (HP:0001254)	2.02223464
60	Increased muscle lipid content (HP:0009058)	1.97929599
61	Arthropathy (HP:0003040)	1.96243653
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.95441758
63	Type I transferrin isoform profile (HP:0003642)	1.94866837
64	Lactic acidosis (HP:0003128)	1.94026796
65	Attenuation of retinal blood vessels (HP:0007843)	1.93952978
66	Renal cortical cysts (HP:0000803)	1.93736215
67	Chronic hepatic failure (HP:0100626)	1.93471737
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92672539
69	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92672539
70	Progressive macrocephaly (HP:0004481)	1.92361723
71	Hypoglycemic coma (HP:0001325)	1.92348380
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.90973077
73	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.88768312
74	Abnormality of vitamin metabolism (HP:0100508)	1.88479451
75	Hyperphosphaturia (HP:0003109)	1.84524037
76	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.84018642
77	Respiratory difficulties (HP:0002880)	1.83544003
78	3-Methylglutaconic aciduria (HP:0003535)	1.82486532
79	Pancytopenia (HP:0001876)	1.81766248
80	Abnormal lung lobation (HP:0002101)	1.81485554
81	Hypolipoproteinemia (HP:0010981)	1.81443087
82	Abnormality of midbrain morphology (HP:0002418)	1.80976529
83	Molar tooth sign on MRI (HP:0002419)	1.80976529
84	Hyperammonemia (HP:0001987)	1.79838080
85	Aplasia/Hypoplasia of the macula (HP:0008059)	1.79813093
86	Congenital stationary night blindness (HP:0007642)	1.79709736
87	Abnormality of renal resorption (HP:0011038)	1.79299881
88	Nephronophthisis (HP:0000090)	1.78692439
89	Bilateral microphthalmos (HP:0007633)	1.78526851
90	Decreased central vision (HP:0007663)	1.78434582
91	Abnormal protein N-linked glycosylation (HP:0012347)	1.78346418
92	Abnormal protein glycosylation (HP:0012346)	1.78346418
93	Abnormal glycosylation (HP:0012345)	1.78346418
94	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78346418
95	Gonadotropin excess (HP:0000837)	1.73925558
96	Homocystinuria (HP:0002156)	1.73109297
97	Abnormality of homocysteine metabolism (HP:0010919)	1.73109297
98	Abnormality of the preputium (HP:0100587)	1.72318543
99	Colon cancer (HP:0003003)	1.70948067
100	Sloping forehead (HP:0000340)	1.70924462

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	3.46502054
2	TSSK6	3.08454726
3	TRIM28	3.08450350
4	MAP4K2	2.96799590
5	PBK	2.53369003
6	NUAK1	2.46955393
7	WNK3	2.43706088
8	ACVR1B	2.40680573
9	SRPK1	2.35609363
10	EIF2AK1	2.23733344
11	BCKDK	2.15605811
12	TAF1	1.98853155
13	PLK3	1.98377178
14	ADRBK2	1.96487842
15	NEK1	1.95103654
16	MST4	1.89796546
17	FRK	1.82253789
18	STK16	1.81803286
19	BMPR1B	1.81151460
20	ERBB3	1.80679617
21	PINK1	1.78494943
22	MKNK1	1.75676905
23	NME1	1.70597279
24	MAP3K12	1.69507114
25	GRK7	1.69094446
26	ZAK	1.66121722
27	BUB1	1.62685839
28	MKNK2	1.51496943
29	TNIK	1.48846003
30	WNK4	1.47684969
31	STK38L	1.42253444
32	FER	1.30599326
33	BRSK2	1.29525549
34	IRAK1	1.12830595
35	PDK2	1.09862052
36	STK39	1.09001580
37	FGFR1	1.08966955
38	BCR	1.08408535
39	GRK1	1.08321345
40	CSNK1G1	1.04279449
41	EIF2AK2	1.02017003
42	PAK3	1.01108875
43	PLK2	1.00964185
44	BMPR2	1.00510129
45	FGR	1.00004940
46	FLT3	1.00003557
47	CDK3	0.98540647
48	CDC7	0.96958553
49	PLK1	0.85181636
50	RPS6KA4	0.83881546
51	ERBB4	0.83402312
52	ALK	0.83343604
53	WEE1	0.82900608
54	VRK1	0.81426211
55	TGFBR1	0.81040560
56	MAP3K9	0.77134474
57	PLK4	0.77085631
58	CSNK1G3	0.76525977
59	MAPK13	0.76322204
60	DAPK1	0.75898934
61	VRK2	0.75449258
62	PRKCE	0.72922256
63	CASK	0.70911717
64	TGFBR2	0.70734706
65	OXSR1	0.69949926
66	TEC	0.68470194
67	TTK	0.66231590
68	STK3	0.63788796
69	NLK	0.59066899
70	BLK	0.56476238
71	INSRR	0.55006842
72	CSNK1A1L	0.52943694
73	DYRK3	0.52550266
74	NEK6	0.51379162
75	MUSK	0.51291123
76	IRAK2	0.49458734
77	ATR	0.47509553
78	CSNK1G2	0.47498649
79	PASK	0.46766024
80	PRKG2	0.45684071
81	DAPK2	0.45031247
82	TIE1	0.44887198
83	CAMK2A	0.44479452
84	AURKB	0.40889798
85	CSNK2A1	0.39443065
86	STK10	0.38928724
87	DYRK2	0.38701389
88	ATM	0.38659103
89	MET	0.38070914
90	MAP2K6	0.37995657
91	PNCK	0.37307862
92	ADRBK1	0.35002415
93	CSNK2A2	0.34992304
94	CSNK1A1	0.33658892
95	PRKACB	0.32181183
96	IKBKE	0.30695156
97	YES1	0.30285405
98	TAOK1	0.27887361
99	MATK	0.26790108
100	STK4	0.26669636

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.33548343
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.73461375
3	Propanoate metabolism_Homo sapiens_hsa00640	2.64505178
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.46646528
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18589586
6	Protein export_Homo sapiens_hsa03060	2.17189224
7	Butanoate metabolism_Homo sapiens_hsa00650	2.16716483
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.16086832
9	One carbon pool by folate_Homo sapiens_hsa00670	2.03071632
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.99970629
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96007683
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.91613285
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.91140897
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.91107176
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.90705783
16	Caffeine metabolism_Homo sapiens_hsa00232	1.85772276
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.84874352
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.83417552
19	Basal transcription factors_Homo sapiens_hsa03022	1.75745983
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70924099
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70135156
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.67047774
23	Parkinsons disease_Homo sapiens_hsa05012	1.64947599
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.60864847
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.58744467
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.58185476
27	Fatty acid elongation_Homo sapiens_hsa00062	1.58080528
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57072381
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.54431068
30	RNA polymerase_Homo sapiens_hsa03020	1.54175168
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.52732103
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52127845
33	RNA degradation_Homo sapiens_hsa03018	1.50430263
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.49513462
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.48732061
36	Fatty acid degradation_Homo sapiens_hsa00071	1.45533338
37	Mismatch repair_Homo sapiens_hsa03430	1.44597544
38	RNA transport_Homo sapiens_hsa03013	1.38941337
39	Glutathione metabolism_Homo sapiens_hsa00480	1.37220443
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.36277717
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.34576922
42	Retinol metabolism_Homo sapiens_hsa00830	1.26423259
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.25779019
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.18965697
45	DNA replication_Homo sapiens_hsa03030	1.18260794
46	Peroxisome_Homo sapiens_hsa04146	1.17928720
47	Homologous recombination_Homo sapiens_hsa03440	1.17887824
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.15690768
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.13668738
50	Complement and coagulation cascades_Homo sapiens_hsa04610	1.13501033
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12565449
52	Linoleic acid metabolism_Homo sapiens_hsa00591	1.11666187
53	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10923126
54	Sulfur metabolism_Homo sapiens_hsa00920	1.06232264
55	Spliceosome_Homo sapiens_hsa03040	1.05502288
56	Huntingtons disease_Homo sapiens_hsa05016	1.02157551
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97921738
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97835100
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.96690672
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.93038689
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90080704
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.89923836
63	Purine metabolism_Homo sapiens_hsa00230	0.85898042
64	Metabolic pathways_Homo sapiens_hsa01100	0.85586340
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.84639710
66	Alzheimers disease_Homo sapiens_hsa05010	0.83109951
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.82966926
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.82549760
69	Carbon metabolism_Homo sapiens_hsa01200	0.76183581
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75830201
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.73392091
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73317854
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73007695
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.72965838
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.72328351
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66988786
77	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65325162
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60256677
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59806246
80	Base excision repair_Homo sapiens_hsa03410	0.59698227
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58422231
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57477884
83	Histidine metabolism_Homo sapiens_hsa00340	0.56080176
84	Folate biosynthesis_Homo sapiens_hsa00790	0.53468375
85	Phototransduction_Homo sapiens_hsa04744	0.50446988
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.50386324
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.43076342
88	p53 signaling pathway_Homo sapiens_hsa04115	0.41982403
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41720171
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40610717
91	Ribosome_Homo sapiens_hsa03010	0.39567214
92	Arginine biosynthesis_Homo sapiens_hsa00220	0.35951923
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31712887
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28474309
95	ABC transporters_Homo sapiens_hsa02010	0.27556305
96	Legionellosis_Homo sapiens_hsa05134	0.27409034
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26045297
98	Regulation of autophagy_Homo sapiens_hsa04140	0.26009059
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25604997
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25145224

FAM35DP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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