FAM3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin filament depolymerization (GO:0030042)6.18558277
2bile acid and bile salt transport (GO:0015721)6.17876972
3activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO6.10799079
4flavonoid metabolic process (GO:0009812)6.06336520
5intestinal absorption (GO:0050892)6.03634063
6maintenance of gastrointestinal epithelium (GO:0030277)5.88052089
7epoxygenase P450 pathway (GO:0019373)5.33433752
8regulation of interferon-beta biosynthetic process (GO:0045357)5.27849453
9purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.17415915
103-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.17415915
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.16869005
12regulation of bile acid biosynthetic process (GO:0070857)5.07066362
13pyrimidine-containing compound transmembrane transport (GO:0072531)5.04743449
14NADH metabolic process (GO:0006734)4.87260090
15epithelial structure maintenance (GO:0010669)4.82823209
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.79476551
17lipoprotein transport (GO:0042953)4.65308796
18regulation of cellular extravasation (GO:0002691)4.63900342
19fat-soluble vitamin biosynthetic process (GO:0042362)4.54528905
20cellular response to virus (GO:0098586)4.53703925
21angiotensin maturation (GO:0002003)4.44222410
22peptide hormone processing (GO:0016486)4.42881977
23sulfate transmembrane transport (GO:1902358)4.40231644
24fructose metabolic process (GO:0006000)4.38645237
25regulation of systemic arterial blood pressure by hormone (GO:0001990)4.37392618
26regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.37392618
27endocrine process (GO:0050886)4.37392618
28cGMP-mediated signaling (GO:0019934)4.27580876
29vitamin transmembrane transport (GO:0035461)4.21131073
30uterus development (GO:0060065)4.17690581
31transcytosis (GO:0045056)4.16723018
32drug metabolic process (GO:0017144)4.14161989
33intestinal cholesterol absorption (GO:0030299)4.13548719
34phosphatidylcholine biosynthetic process (GO:0006656)4.10927261
35desmosome organization (GO:0002934)4.10185940
36antibacterial humoral response (GO:0019731)4.08349404
37positive regulation of respiratory burst (GO:0060267)4.07568178
38very-low-density lipoprotein particle assembly (GO:0034379)4.04391199
39diacylglycerol metabolic process (GO:0046339)4.02335474
40sulfation (GO:0051923)4.00815096
41cellular glucuronidation (GO:0052695)3.99766714
42positive regulation of glycoprotein biosynthetic process (GO:0010560)3.97396065
43antimicrobial humoral response (GO:0019730)3.92698433
44regulation of systemic arterial blood pressure (GO:0003073)3.89386508
45regulation of guanylate cyclase activity (GO:0031282)3.86115398
46positive regulation of glycoprotein metabolic process (GO:1903020)3.83836024
47cobalamin metabolic process (GO:0009235)3.82007719
48bicarbonate transport (GO:0015701)3.77086586
49hormone catabolic process (GO:0042447)3.76416903
50sulfur amino acid catabolic process (GO:0000098)3.71972393
51digestive system process (GO:0022600)3.71672924
52response to hepatocyte growth factor (GO:0035728)3.69831933
53cellular response to hepatocyte growth factor stimulus (GO:0035729)3.69831933
54peptide catabolic process (GO:0043171)3.67580127
55transepithelial transport (GO:0070633)3.64610478
56plasma lipoprotein particle assembly (GO:0034377)3.56793938
57auditory receptor cell differentiation (GO:0042491)3.54681401
58positive regulation of guanylate cyclase activity (GO:0031284)3.52608289
59regulation of actin nucleation (GO:0051125)3.52247852
60macroautophagy (GO:0016236)3.52159268
61sulfate transport (GO:0008272)3.49622845
62positive regulation of pseudopodium assembly (GO:0031274)3.48472386
63UDP-N-acetylglucosamine metabolic process (GO:0006047)3.47800503
64thrombin receptor signaling pathway (GO:0070493)3.47054947
65arginine metabolic process (GO:0006525)3.46262983
66response to pheromone (GO:0019236)3.43653192
67uronic acid metabolic process (GO:0006063)3.43520094
68glucuronate metabolic process (GO:0019585)3.43520094
69receptor guanylyl cyclase signaling pathway (GO:0007168)3.40835759
70negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.38584820
71neurotransmitter biosynthetic process (GO:0042136)3.35738965
72sulfur compound transport (GO:0072348)3.35585174
73positive regulation of T cell differentiation in thymus (GO:0033089)3.34452432
74fucose catabolic process (GO:0019317)3.34238114
75L-fucose metabolic process (GO:0042354)3.34238114
76L-fucose catabolic process (GO:0042355)3.34238114
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.33737054
78macrophage chemotaxis (GO:0048246)3.33174363
79positive regulation of interferon-alpha production (GO:0032727)3.30725545
80vitamin A metabolic process (GO:0006776)3.30641120
81regulation of cholesterol esterification (GO:0010872)3.28845132
82ethanol oxidation (GO:0006069)3.26361022
83glucose 6-phosphate metabolic process (GO:0051156)3.26104168
84regulation of viral release from host cell (GO:1902186)3.25110635
85vitamin transport (GO:0051180)3.24921181
86L-ascorbic acid metabolic process (GO:0019852)3.24049173
87glycolipid catabolic process (GO:0019377)3.23994605
88intestinal epithelial cell development (GO:0060576)3.22960066
89phospholipid efflux (GO:0033700)3.21523494
90low-density lipoprotein particle remodeling (GO:0034374)3.18652460
91negative regulation of sterol transport (GO:0032372)3.18545634
92negative regulation of cholesterol transport (GO:0032375)3.18545634
93high-density lipoprotein particle remodeling (GO:0034375)3.18516855
94lipoprotein metabolic process (GO:0042157)3.17987355
95calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.17968598
96sphingomyelin metabolic process (GO:0006684)3.16785643
97low-density lipoprotein particle clearance (GO:0034383)3.16615354
98exogenous drug catabolic process (GO:0042738)3.16524869
99regulation of cGMP metabolic process (GO:0030823)3.15609532
100protein targeting to Golgi (GO:0000042)3.15310404
101negative regulation of protein tyrosine kinase activity (GO:0061099)3.13304750
102nucleotide transmembrane transport (GO:1901679)3.13073092
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12776481
104phosphatidylserine acyl-chain remodeling (GO:0036150)3.12650728
105regulation of protein glycosylation (GO:0060049)3.12419601
106regulation of pseudopodium assembly (GO:0031272)3.11275425
107plasma lipoprotein particle remodeling (GO:0034369)3.09846085
108protein-lipid complex remodeling (GO:0034368)3.09846085
109macromolecular complex remodeling (GO:0034367)3.09846085
110phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.09824322
111digestion (GO:0007586)3.08912375
112protein-lipid complex assembly (GO:0065005)3.08291399
113drug catabolic process (GO:0042737)3.08097871
114regulation of interferon-alpha production (GO:0032647)3.07978401
115bile acid metabolic process (GO:0008206)3.07213748
116negative regulation of epidermal cell differentiation (GO:0045605)3.05240539
117eosinophil chemotaxis (GO:0048245)3.04887595
118vitamin biosynthetic process (GO:0009110)3.03576935
119renal system process involved in regulation of blood volume (GO:0001977)3.03394925
120urea cycle (GO:0000050)2.99004468
121primary alcohol catabolic process (GO:0034310)2.98534807
122regulation of cholesterol homeostasis (GO:2000188)2.98135314
123glutathione biosynthetic process (GO:0006750)2.96768283
124O-glycan processing (GO:0016266)2.95123566
125ribonucleoside bisphosphate metabolic process (GO:0033875)2.94007919
126nucleoside bisphosphate metabolic process (GO:0033865)2.94007919
127purine nucleoside bisphosphate metabolic process (GO:0034032)2.94007919
128positive regulation of cGMP biosynthetic process (GO:0030828)2.93058375
129reverse cholesterol transport (GO:0043691)2.90320509
130response to hydroperoxide (GO:0033194)2.89593878
131drug transport (GO:0015893)2.89343912
132plasma lipoprotein particle organization (GO:0071827)2.89116460
133cellular anion homeostasis (GO:0030002)2.88835843
134nonribosomal peptide biosynthetic process (GO:0019184)2.86630221
135complement activation, classical pathway (GO:0006958)2.86098129
136cholesterol homeostasis (GO:0042632)2.85887052
137urea metabolic process (GO:0019627)2.85760115
138negative regulation of defense response to virus (GO:0050687)2.84482255
139regulation of vitamin metabolic process (GO:0030656)2.84464494
140regulation of viral entry into host cell (GO:0046596)2.84294816
141cytokine biosynthetic process (GO:0042089)2.83916822
142epithelial cell-cell adhesion (GO:0090136)2.83653643
143virion attachment to host cell (GO:0019062)2.83105318
144adhesion of symbiont to host cell (GO:0044650)2.83105318
145fat-soluble vitamin metabolic process (GO:0006775)2.82875718
146nucleotide-sugar biosynthetic process (GO:0009226)2.82697767
147glutamine family amino acid biosynthetic process (GO:0009084)2.82582123
148phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82369202
149phosphatidylcholine metabolic process (GO:0046470)2.80162807
150membrane lipid catabolic process (GO:0046466)2.80035481
151sterol homeostasis (GO:0055092)2.79635060
152negative regulation of T cell differentiation in thymus (GO:0033085)2.78245340
153sperm capacitation (GO:0048240)2.77545020
154chondrocyte proliferation (GO:0035988)2.76958754
155ceramide catabolic process (GO:0046514)2.76795942
156purine ribonucleotide transport (GO:0015868)2.75901912
157filopodium assembly (GO:0046847)2.74920246
158oligosaccharide biosynthetic process (GO:0009312)2.74748412
159thyroid hormone metabolic process (GO:0042403)2.74204287
160leukocyte apoptotic process (GO:0071887)2.69842555
161regulation of triglyceride catabolic process (GO:0010896)2.68318946
162regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.67190376
163regulation of cGMP biosynthetic process (GO:0030826)2.66515574
164ethanol metabolic process (GO:0006067)2.66487148
165alkaloid metabolic process (GO:0009820)2.66337681
166galactose catabolic process (GO:0019388)2.65415639
167positive regulation of actin cytoskeleton reorganization (GO:2000251)2.65326962
168regulation of cholesterol biosynthetic process (GO:0045540)2.65224173
169establishment of protein localization to Golgi (GO:0072600)2.64533652
170regulation of proton transport (GO:0010155)2.64337466
171regulation of Golgi to plasma membrane protein transport (GO:0042996)2.64311623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.84441605
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07278093
3* SRY_22984422_ChIP-ChIP_TESTIS_Rat3.99255297
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.64290002
5* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.21422577
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.03015216
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97447414
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.94253411
9* SOX2_20726797_ChIP-Seq_SW620_Human2.57308281
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.50371020
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48069957
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45072313
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29257062
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.19292042
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17336769
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09330859
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05736219
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03462378
19GATA4_25053715_ChIP-Seq_YYC3_Human2.02245911
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97250594
21GATA6_25053715_ChIP-Seq_YYC3_Human1.92977111
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.88091354
23EGR1_19032775_ChIP-ChIP_M12_Human1.81332072
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80535638
25BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.79443687
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.75280967
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74359520
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.72846303
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.68637540
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.65925455
31FOXA1_25552417_ChIP-Seq_VCAP_Human1.64180004
32CDX2_22108803_ChIP-Seq_LS180_Human1.58799405
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53955738
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52713349
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.50283863
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49318185
37KLF5_25053715_ChIP-Seq_YYC3_Human1.45499722
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43048930
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41877012
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39634199
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39007703
42RACK7_27058665_Chip-Seq_MCF-7_Human1.37195912
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.35628691
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31809894
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29627569
46LXR_22292898_ChIP-Seq_THP-1_Human1.28135911
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26196312
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24746354
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24656910
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24326684
51AR_20517297_ChIP-Seq_VCAP_Human1.20603746
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19674027
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19623758
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16805633
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.16805633
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16117753
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.15972638
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14859715
59BCAT_22108803_ChIP-Seq_LS180_Human1.14024720
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12591349
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12519067
62* GATA3_24758297_ChIP-Seq_MCF-7_Human1.11830740
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11452663
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.10418639
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09676430
66CEBPB_22108803_ChIP-Seq_LS180_Human1.09588320
67VDR_22108803_ChIP-Seq_LS180_Human1.09070695
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08417059
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.06106942
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03487891
71MYC_19915707_ChIP-ChIP_AK7_Human1.02441178
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02104930
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.01494093
74* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00277181
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99271675
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99063197
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98848951
78TCF4_22108803_ChIP-Seq_LS180_Human0.98601675
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98269260
80NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97255350
81RBPJ_21746931_ChIP-Seq_IB4_Human0.95979987
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94388330
83DROSHA_22980978_ChIP-Seq_HELA_Human0.94141379
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.92902218
85RUNX1_27514584_Chip-Seq_MCF-7_Human0.92777062
86ETV1_20927104_ChIP-Seq_GIST48_Human0.91837938
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91740498
88NANOG_20526341_ChIP-Seq_ESCs_Human0.91696479
89BCL6_27268052_Chip-Seq_Bcells_Human0.91482509
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91350667
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90947878
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90773492
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90500368
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90265126
95NCOR_22424771_ChIP-Seq_293T_Human0.89875667
96MYC_19829295_ChIP-Seq_ESCs_Human0.89211477
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89161716
98TP63_23658742_ChIP-Seq_EP156T_Human0.89016435
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88875333
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88845430
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88165355
102NFYA_21822215_ChIP-Seq_K562_Human0.88041467
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87951339
104TAF2_19829295_ChIP-Seq_ESCs_Human0.87762560
105PHF8_20622853_ChIP-Seq_HELA_Human0.86901290
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86329497
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86197987
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85921377
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85921377
110GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85258557
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84977590
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84885554
113ATF3_27146783_Chip-Seq_COLON_Human0.84759290
114EZH2_27294783_Chip-Seq_ESCs_Mouse0.84599317
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84334568
116* STAT1_20625510_ChIP-Seq_HELA_Human0.84092205
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84028534
118RXR_22108803_ChIP-Seq_LS180_Human0.82918962
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82879753
120NANOG_19829295_ChIP-Seq_ESCs_Human0.82463418
121SOX2_19829295_ChIP-Seq_ESCs_Human0.82463418
122SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81907491
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81863003
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.81845415
125TP53_16413492_ChIP-PET_HCT116_Human0.81356968
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80298905
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.79957561
128P53_21459846_ChIP-Seq_SAOS-2_Human0.79091681
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78936188
130SA1_27219007_Chip-Seq_Bcells_Human0.78903458
131CBP_21632823_ChIP-Seq_H3396_Human0.78693449
132CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78429963
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78289284
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.77815156
135GATA2_19941826_ChIP-Seq_K562_Human0.77436711
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77195770
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76887308
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76307631
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75568966
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75566942
141CTCF_27219007_Chip-Seq_Bcells_Human0.74621007
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74130847
143PHF8_20622854_ChIP-Seq_HELA_Human0.73996514
144GATA3_21867929_ChIP-Seq_CD8_Mouse0.73302390
145MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72080215
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.71004811
147* HNF4A_19822575_ChIP-Seq_HepG2_Human0.70746069
148TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70533915
149E2F1_20622854_ChIP-Seq_HELA_Human0.70437339
150MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70009192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.66095299
2MP0002822_catalepsy5.86507689
3MP0003283_abnormal_digestive_organ4.38863526
4MP0005377_hearing/vestibular/ear_phenot4.35129270
5MP0003878_abnormal_ear_physiology4.35129270
6MP0005360_urolithiasis3.67150136
7MP0001666_abnormal_nutrient_absorption3.46433449
8MP0003315_abnormal_perineum_morphology3.37035256
9MP0003183_abnormal_peptide_metabolism3.30183762
10MP0000462_abnormal_digestive_system3.12332171
11MP0010352_gastrointestinal_tract_polyps3.02671081
12MP0008004_abnormal_stomach_pH2.75225493
13MP0005167_abnormal_blood-brain_barrier2.74751560
14MP0008875_abnormal_xenobiotic_pharmacok2.72593773
15MP0001873_stomach_inflammation2.66233113
16MP0003866_abnormal_defecation2.57805868
17MP0004264_abnormal_extraembryonic_tissu2.22879915
18MP0005332_abnormal_amino_acid2.19606913
19MP0005381_digestive/alimentary_phenotyp2.17471261
20MP0001663_abnormal_digestive_system2.09307135
21MP0001664_abnormal_digestion2.05630142
22MP0001849_ear_inflammation2.03294994
23MP0010155_abnormal_intestine_physiology2.03136286
24MP0005085_abnormal_gallbladder_physiolo2.01533168
25MP0009379_abnormal_foot_pigmentation2.01000863
26MP0003806_abnormal_nucleotide_metabolis1.96651403
27MP0003191_abnormal_cellular_cholesterol1.93692803
28MP0002796_impaired_skin_barrier1.93067745
29MP0002138_abnormal_hepatobiliary_system1.91948746
30MP0004947_skin_inflammation1.80073191
31MP0001756_abnormal_urination1.72307172
32MP0004858_abnormal_nervous_system1.64897998
33MP0000477_abnormal_intestine_morphology1.64572241
34MP0004019_abnormal_vitamin_homeostasis1.59183336
35MP0000490_abnormal_crypts_of1.57346696
36MP0003195_calcinosis1.55740843
37MP0003252_abnormal_bile_duct1.47533830
38MP0000538_abnormal_urinary_bladder1.47470204
39MP0000579_abnormal_nail_morphology1.45646832
40MP0001764_abnormal_homeostasis1.45508640
41MP0009785_altered_susceptibility_to1.45437583
42MP0003941_abnormal_skin_development1.42773643
43MP0000470_abnormal_stomach_morphology1.41912154
44MP0001765_abnormal_ion_homeostasis1.36449011
45MP0002139_abnormal_hepatobiliary_system1.33231552
46MP0005448_abnormal_energy_balance1.32782911
47MP0004043_abnormal_pH_regulation1.28516218
48MP0004270_analgesia1.25654931
49MP0009780_abnormal_chondrocyte_physiolo1.24991072
50MP0010678_abnormal_skin_adnexa1.23714367
51MP0005645_abnormal_hypothalamus_physiol1.21396279
52MP0003718_maternal_effect1.21270601
53MP0005310_abnormal_salivary_gland1.18982363
54MP0003303_peritoneal_inflammation1.14366641
55MP0003385_abnormal_body_wall1.14352153
56MP0009643_abnormal_urine_homeostasis1.12272867
57MP0010329_abnormal_lipoprotein_level1.11418543
58MP0000372_irregular_coat_pigmentation1.11028539
59MP0003705_abnormal_hypodermis_morpholog1.09147700
60MP0002163_abnormal_gland_morphology1.07562483
61MP0005636_abnormal_mineral_homeostasis1.07536014
62MP0008872_abnormal_physiological_respon1.04539074
63MP0009278_abnormal_bone_marrow1.03452224
64MP0002166_altered_tumor_susceptibility1.03084130
65MP0002078_abnormal_glucose_homeostasis1.01934307
66MP0005409_darkened_coat_color1.01281147
67MP0005379_endocrine/exocrine_gland_phen0.99773328
68MP0000230_abnormal_systemic_arterial0.99463483
69MP0005025_abnormal_response_to0.97971201
70MP0005501_abnormal_skin_physiology0.96211202
71MP0000013_abnormal_adipose_tissue0.93634148
72MP0002693_abnormal_pancreas_physiology0.92804177
73MP0003724_increased_susceptibility_to0.91220943
74MP0005410_abnormal_fertilization0.90133544
75MP0001485_abnormal_pinna_reflex0.89562112
76MP0005535_abnormal_body_temperature0.88882247
77MP0003953_abnormal_hormone_level0.88872311
78MP0001216_abnormal_epidermal_layer0.85648761
79MP0005365_abnormal_bile_salt0.85593944
80MP0002148_abnormal_hypersensitivity_rea0.85105286
81MP0002160_abnormal_reproductive_system0.83532313
82MP0005076_abnormal_cell_differentiation0.82611345
83MP0002089_abnormal_postnatal_growth/wei0.82109401
84MP0005670_abnormal_white_adipose0.79761434
85MP0005166_decreased_susceptibility_to0.77905420
86MP0004147_increased_porphyrin_level0.76476881
87MP0003300_gastrointestinal_ulcer0.76054137
88MP0002136_abnormal_kidney_physiology0.76015163
89MP0003453_abnormal_keratinocyte_physiol0.74392524
90MP0009840_abnormal_foam_cell0.72843342
91MP0002971_abnormal_brown_adipose0.72841449
92MP0000516_abnormal_urinary_system0.71569044
93MP0005367_renal/urinary_system_phenotyp0.71569044
94MP0005000_abnormal_immune_tolerance0.70724670
95MP0002118_abnormal_lipid_homeostasis0.70060865
96MP0002277_abnormal_respiratory_mucosa0.69850169
97MP0001501_abnormal_sleep_pattern0.69371211
98MP0001188_hyperpigmentation0.68952941
99MP0000609_abnormal_liver_physiology0.68558893
100MP0001845_abnormal_inflammatory_respons0.68279732
101MP0002098_abnormal_vibrissa_morphology0.66534536
102MP0001944_abnormal_pancreas_morphology0.65950624
103MP0004185_abnormal_adipocyte_glucose0.65867820
104MP0003868_abnormal_feces_composition0.63991291
105MP0003879_abnormal_hair_cell0.63942364
106MP0004782_abnormal_surfactant_physiolog0.62630840
107MP0003045_fibrosis0.60878789
108MP0003436_decreased_susceptibility_to0.60160438
109MP0005395_other_phenotype0.60121158
110MP0008775_abnormal_heart_ventricle0.59924011
111MP0000465_gastrointestinal_hemorrhage0.59661111
112MP0008873_increased_physiological_sensi0.59047357
113MP0005584_abnormal_enzyme/coenzyme_acti0.57139745
114MP0000566_synostosis0.56437778
115MP0002060_abnormal_skin_morphology0.56216020
116MP0005220_abnormal_exocrine_pancreas0.55693304
117MP0006082_CNS_inflammation0.55065965
118MP0009115_abnormal_fat_cell0.53588437
119MP0003638_abnormal_response/metabolism_0.53513360
120MP0001727_abnormal_embryo_implantation0.53293997
121MP0000537_abnormal_urethra_morphology0.52778770
122MP0002419_abnormal_innate_immunity0.52761303
123MP0000685_abnormal_immune_system0.52634298
124MP0002909_abnormal_adrenal_gland0.51910594
125MP0000678_abnormal_parathyroid_gland0.51613475
126MP0002837_dystrophic_cardiac_calcinosis0.51270053
127MP0001533_abnormal_skeleton_physiology0.49552150
128MP0000467_abnormal_esophagus_morphology0.49130285
129MP0005319_abnormal_enzyme/_coenzyme0.48959354
130MP0010386_abnormal_urinary_bladder0.48766984
131MP0008469_abnormal_protein_level0.47522767
132MP0002896_abnormal_bone_mineralization0.47190523
133MP0002006_tumorigenesis0.45324083
134MP0009642_abnormal_blood_homeostasis0.44693948
135MP0003075_altered_response_to0.42436664
136MP0002452_abnormal_antigen_presenting0.41738738
137MP0002876_abnormal_thyroid_physiology0.41525313
138MP0005387_immune_system_phenotype0.39567215
139MP0001790_abnormal_immune_system0.39567215
140MP0002234_abnormal_pharynx_morphology0.37811451
141MP0005023_abnormal_wound_healing0.36518875

Predicted human phenotypes

RankGene SetZ-score
1Cupped ribs (HP:0000887)6.74128954
2Hydroxyprolinuria (HP:0003080)5.64355096
3Abnormality of proline metabolism (HP:0010907)5.64355096
4Abnormality of vitamin B metabolism (HP:0004340)4.89680467
5Septate vagina (HP:0001153)4.70786161
6Hypobetalipoproteinemia (HP:0003563)4.69051177
7Right ventricular cardiomyopathy (HP:0011663)4.60617449
8Abnormality of the vitamin B12 metabolism (HP:0004341)4.58028630
9Ileus (HP:0002595)4.21924960
10Abnormal tarsal ossification (HP:0008369)4.16514027
11Polycythemia (HP:0001901)4.04029860
12Flat acetabular roof (HP:0003180)4.03709056
13Abnormality of vitamin metabolism (HP:0100508)4.01609208
14Abnormality of the 1st metacarpal (HP:0010009)4.00373413
15Glycosuria (HP:0003076)3.95286944
16Abnormality of urine glucose concentration (HP:0011016)3.95286944
17Retrobulbar optic neuritis (HP:0100654)3.87435707
18Optic neuritis (HP:0100653)3.87435707
19Decreased circulating renin level (HP:0003351)3.83732492
20Breech presentation (HP:0001623)3.79522954
21Villous atrophy (HP:0011473)3.74522271
22Abnormality of small intestinal villus morphology (HP:0011472)3.74522271
23Steatorrhea (HP:0002570)3.73659216
24Abnormality of carpal bone ossification (HP:0006257)3.69522012
25Abnormality of the proximal phalanges of the hand (HP:0009834)3.64820783
26Malnutrition (HP:0004395)3.60141600
27Orchitis (HP:0100796)3.54887929
28Proximal tubulopathy (HP:0000114)3.47923307
29Xanthomatosis (HP:0000991)3.47725486
30Spastic paraparesis (HP:0002313)3.45255771
31Pustule (HP:0200039)3.44246974
32Ureteral stenosis (HP:0000071)3.41663136
33Elevated erythrocyte sedimentation rate (HP:0003565)3.36592689
34Hyperactive renin-angiotensin system (HP:0000841)3.16077190
35Ureteral obstruction (HP:0006000)3.10205171
36Gastrointestinal dysmotility (HP:0002579)3.07610247
37Confusion (HP:0001289)3.06490046
38Tongue fasciculations (HP:0001308)3.05722504
39Sensorimotor neuropathy (HP:0007141)3.05010365
40Hyperglycinuria (HP:0003108)3.04018269
41Abdominal distention (HP:0003270)3.02345250
42Abnormality of renin-angiotensin system (HP:0000847)2.97779802
43Alkalosis (HP:0001948)2.95443821
44Late onset (HP:0003584)2.93464597
45Abnormality of the 2nd finger (HP:0004100)2.87737041
46Hypoglycemic coma (HP:0001325)2.87630367
47Congenital sensorineural hearing impairment (HP:0008527)2.85857480
48Abnormality of the middle phalanges of the toes (HP:0010183)2.81359012
49Abnormality of the phalanges of the hallux (HP:0010057)2.80076920
50Acanthocytosis (HP:0001927)2.79905583
51Abnormal ossification of hand bones (HP:0005921)2.78435607
52Nausea (HP:0002018)2.77336234
53Facial shape deformation (HP:0011334)2.74733554
54Potter facies (HP:0002009)2.74733554
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.73064139
56Short phalanx of the thumb (HP:0009660)2.72900670
57Muscle fibrillation (HP:0010546)2.72739141
58Abnormality of serine family amino acid metabolism (HP:0010894)2.71891166
59Abnormality of glycine metabolism (HP:0010895)2.71891166
60Peritonitis (HP:0002586)2.71170166
61Abnormal foot bone ossification (HP:0010675)2.69335059
62Hyperuricemia (HP:0002149)2.68902167
63Increased purine levels (HP:0004368)2.68902167
64Glomerulonephritis (HP:0000099)2.68758972
65Petechiae (HP:0000967)2.67083365
66Gout (HP:0001997)2.65585816
67Abnormal hand bone ossification (HP:0010660)2.64647760
68Myositis (HP:0100614)2.64223134
69Symptomatic seizures (HP:0011145)2.62111098
70Ovoid vertebral bodies (HP:0003300)2.61816652
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.61766176
72Hypoglycemic seizures (HP:0002173)2.58284868
73Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.58012254
74Symphalangism affecting the phalanges of the hand (HP:0009773)2.57976584
75Esophageal varix (HP:0002040)2.56945316
76Gastrointestinal infarctions (HP:0005244)2.55012562
77Ketoacidosis (HP:0001993)2.54652897
78Hypothermia (HP:0002045)2.50520993
79Hyperammonemia (HP:0001987)2.49691452
80Megaloblastic anemia (HP:0001889)2.48434170
81Metabolic acidosis (HP:0001942)2.48330132
82Hyperphosphatemia (HP:0002905)2.48247992
83Metabolic alkalosis (HP:0200114)2.46928580
84Intrahepatic cholestasis (HP:0001406)2.46521982
85Epidermoid cyst (HP:0200040)2.46391071
86Abnormality of magnesium homeostasis (HP:0004921)2.45423642
87Cone-rod dystrophy (HP:0000548)2.44306326
88Hyperphosphaturia (HP:0003109)2.42573309
89Dicarboxylic aciduria (HP:0003215)2.42506666
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42506666
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41241514
92Overlapping toe (HP:0001845)2.40921531
93Abnormality of chloride homeostasis (HP:0011422)2.40902032
94Hypotension (HP:0002615)2.39216398
95Nephrolithiasis (HP:0000787)2.38476769
96Abnormality of purine metabolism (HP:0004352)2.38063678
97Hypolipoproteinemia (HP:0010981)2.36363233
98Pancreatitis (HP:0001733)2.35791818
99Focal segmental glomerulosclerosis (HP:0000097)2.35083683
100Hypoalbuminemia (HP:0003073)2.33932024
101Abnormal albumin level (HP:0012116)2.33932024
102Facial hemangioma (HP:0000329)2.32318278
103Alopecia of scalp (HP:0002293)2.32259681
104Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32188852
105Keratoconjunctivitis sicca (HP:0001097)2.31031939
106Hyperglycemia (HP:0003074)2.26560995
107Abnormal urine phosphate concentration (HP:0012599)2.24833064
108Chronic diarrhea (HP:0002028)2.24809355
109Hypophosphatemia (HP:0002148)2.23911817
110Tracheal stenosis (HP:0002777)2.23835685
111Pigmentary retinal degeneration (HP:0001146)2.22844375
112Ketosis (HP:0001946)2.21591290
113Pili torti (HP:0003777)2.20275912
114Vacuolated lymphocytes (HP:0001922)2.18364502
115Woolly hair (HP:0002224)2.17976671
116Fat malabsorption (HP:0002630)2.17684228
117Dehydration (HP:0001944)2.17658033
118Absent phalangeal crease (HP:0006109)2.17511180
119Exocrine pancreatic insufficiency (HP:0001738)2.14810796
120Complement deficiency (HP:0004431)2.13964715
121Keratoconjunctivitis (HP:0001096)2.12958309
122Short hallux (HP:0010109)2.11082540
123Severe combined immunodeficiency (HP:0004430)2.08552165
124Abnormal glucose tolerance (HP:0001952)2.07289379
125Posterior subcapsular cataract (HP:0007787)2.07286969
126Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06896446
127Micronodular cirrhosis (HP:0001413)2.06567537
128Biliary tract neoplasm (HP:0100574)2.05433354
129Metaphyseal cupping (HP:0003021)2.05360211
130Abnormality of nucleobase metabolism (HP:0010932)2.04537975
131Hyperinsulinemic hypoglycemia (HP:0000825)2.03991426
132Amyloidosis (HP:0011034)2.03958350
133Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.03712297
134Abnormal biliary tract morphology (HP:0012440)2.03177987
135Congenital ichthyosiform erythroderma (HP:0007431)2.01745643
136Paraparesis (HP:0002385)2.00280311
137Lethargy (HP:0001254)1.99908341
138Wide cranial sutures (HP:0010537)1.98206723
139Methylmalonic aciduria (HP:0012120)1.96892880
140Nephritis (HP:0000123)1.96566899
141Aplasia/Hypoplasia of the hallux (HP:0008362)1.94039483
142Irritability (HP:0000737)1.91739114
143Cerebral palsy (HP:0100021)1.91724133
144Combined immunodeficiency (HP:0005387)1.91304799
145Arterial thrombosis (HP:0004420)1.91195620
146Widely patent fontanelles and sutures (HP:0004492)1.90323087
147Hyperaldosteronism (HP:0000859)1.90280639
148Rectal prolapse (HP:0002035)1.89900229
149Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88670064
150Palpitations (HP:0001962)1.88257720
151Cardiovascular calcification (HP:0011915)1.87600803
152Eczematoid dermatitis (HP:0000976)1.87023272
153Generalized aminoaciduria (HP:0002909)1.86236339
154Protuberant abdomen (HP:0001538)1.86102835
155Gangrene (HP:0100758)1.84900125
156Insulin-resistant diabetes mellitus (HP:0000831)1.84176528
157Renal tubular acidosis (HP:0001947)1.83344850
158Abnormality of complement system (HP:0005339)1.82989696
159Hypokalemia (HP:0002900)1.82554248
160Flared iliac wings (HP:0002869)1.82348792
161Coxa vara (HP:0002812)1.82299694
162Fragile nails (HP:0001808)1.81999782
163Vascular calcification (HP:0004934)1.80384149
164Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.80208865
165Abnormality of macular pigmentation (HP:0008002)1.80206600
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.80063206
167Autoimmune thrombocytopenia (HP:0001973)1.79533237
168Hyperparathyroidism (HP:0000843)1.78959954
169Proximal placement of thumb (HP:0009623)1.77571886
170Systemic lupus erythematosus (HP:0002725)1.75673066
171Abnormal finger flexion creases (HP:0006143)1.74557798
172Conjugated hyperbilirubinemia (HP:0002908)1.69160079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.01670538
2MST1R6.00064350
3PIK3CA5.27651483
4TBK15.15213727
5TESK13.40023998
6KSR23.18804930
7MAP2K63.07742845
8MAP2K22.90258240
9MST42.85915410
10IKBKE2.85823101
11RIPK42.75223425
12FRK2.58909396
13MAP3K22.52431555
14STK392.45247629
15LMTK22.42463693
16GRK62.28990518
17EPHA32.21369741
18OXSR12.19571808
19FGFR42.02177040
20TAOK22.01620378
21FGFR31.98481121
22STK241.97687751
23TAOK11.93676235
24PDPK11.81066653
25GRK11.75089541
26LIMK11.74342508
27EPHB21.72405809
28MET1.71941361
29PRKG21.65849780
30MYLK1.58769413
31IKBKB1.53600744
32BLK1.52930788
33RIPK11.52880941
34ARAF1.48404852
35TLK11.42570722
36BMPR21.41471153
37PDK11.35143434
38PDK21.33994500
39EPHB11.33004868
40TNIK1.30954778
41IRAK11.27714034
42MAP3K101.24882015
43PIM21.22006971
44FGFR21.18345048
45MAP3K141.13504874
46MAP2K11.13172198
47MAPKAPK31.12481261
48ERBB41.11992906
49INSRR1.11081888
50MAP3K81.04927294
51ADRBK21.03918210
52MAP3K111.03732549
53MATK0.99188911
54DAPK20.99140961
55NME10.98451044
56MAP4K20.97739243
57CAMK2D0.97243155
58STK100.91315113
59RAF10.89681382
60MELK0.89676907
61CASK0.88943706
62DMPK0.87327582
63STK38L0.86046732
64PRKCI0.82826341
65MAP3K10.77629522
66BMX0.75235707
67CDC42BPA0.72558791
68DDR20.71086702
69MAP3K120.70971397
70WNK30.70493997
71PBK0.69392500
72STK30.68745496
73PIK3CG0.68024825
74TTK0.62740596
75EPHA20.62470157
76PRKCZ0.61706934
77PTK60.57089848
78PRKCE0.56059844
79MAPK110.54070156
80BMPR1B0.53825206
81MAP3K30.52662164
82HIPK20.52081236
83YES10.50720428
84ABL20.50043787
85JAK10.48919473
86BRAF0.48778905
87NUAK10.48716013
88MARK30.48101353
89TESK20.47559907
90TAOK30.47175248
91NLK0.46571757
92AKT30.46340629
93MAP3K50.44785772
94EPHA40.42238087
95PKN10.42062353
96STK110.42011212
97PRKCA0.41578413
98PTK20.41064122
99PIM10.39999953
100ERBB20.37796566
101ERBB30.37197009
102MAP4K10.36635411
103CAMK2G0.36493678
104PRKAA10.36464659
105CSK0.35787494
106CSNK1A10.35087985
107MAP2K30.34610503
108SRC0.34404631
109JAK20.34188061
110DAPK30.32849544
111TXK0.32792223
112PINK10.32531762
113PRKAA20.30537158
114GSK3A0.29442570
115CAMK2B0.27400816
116LYN0.27276757
117PRKACA0.27239724
118PRKCD0.26195336
119PAK30.25698748
120PDK30.24840095
121PDK40.24840095
122FYN0.24407468
123ITK0.23028578
124IGF1R0.21267465
125DAPK10.21231376
126KSR10.21116918
127ERN10.20252640
128PRKG10.19301450
129PRKD10.19291575
130NEK60.19235163
131CDK90.19221927
132MAP3K90.18887794
133PHKG10.18820839
134PHKG20.18820839
135PRKACG0.18505825
136PRKCQ0.18123404
137FER0.17929028
138PRKCB0.17343503
139MAPKAPK20.17342836
140PAK10.17193865
141TYK20.16752816
142MAP3K70.16555519
143CSNK1G10.16540157
144ZAP700.16449109
145PRKACB0.15901876
146MAPK40.15683455
147WNK40.15381212

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.90253278
2Sulfur metabolism_Homo sapiens_hsa009205.85778215
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.16287499
4Mineral absorption_Homo sapiens_hsa049784.07380025
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.78397341
6Fat digestion and absorption_Homo sapiens_hsa049753.34495707
7Bile secretion_Homo sapiens_hsa049762.37514199
8Vitamin digestion and absorption_Homo sapiens_hsa049772.19814831
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87369421
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82522033
11Renin-angiotensin system_Homo sapiens_hsa046141.80517414
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78980023
13Sulfur relay system_Homo sapiens_hsa041221.78235544
14Fructose and mannose metabolism_Homo sapiens_hsa000511.72532966
15Galactose metabolism_Homo sapiens_hsa000521.70200402
16Linoleic acid metabolism_Homo sapiens_hsa005911.67364178
17Histidine metabolism_Homo sapiens_hsa003401.61198321
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49679552
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43001967
20Arginine biosynthesis_Homo sapiens_hsa002201.37196246
21Pertussis_Homo sapiens_hsa051331.32681931
22Arginine and proline metabolism_Homo sapiens_hsa003301.26953967
23Starch and sucrose metabolism_Homo sapiens_hsa005001.26626640
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23095883
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21741341
26Caffeine metabolism_Homo sapiens_hsa002321.21602872
27Steroid biosynthesis_Homo sapiens_hsa001001.18696382
28Asthma_Homo sapiens_hsa053101.17743702
29Chemical carcinogenesis_Homo sapiens_hsa052041.17170814
30Glycerolipid metabolism_Homo sapiens_hsa005611.16681349
31Legionellosis_Homo sapiens_hsa051341.13640958
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13098875
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11628910
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07750370
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07181777
36Type I diabetes mellitus_Homo sapiens_hsa049401.02461344
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01914918
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.99821270
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98661570
40Peroxisome_Homo sapiens_hsa041460.96649000
41Salmonella infection_Homo sapiens_hsa051320.94838968
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93739829
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88599037
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88074298
45PPAR signaling pathway_Homo sapiens_hsa033200.88073663
46Protein digestion and absorption_Homo sapiens_hsa049740.87222866
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.85729247
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84911492
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.83136525
50Fatty acid metabolism_Homo sapiens_hsa012120.82360098
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82294593
52ABC transporters_Homo sapiens_hsa020100.80042041
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76809205
54Hepatitis C_Homo sapiens_hsa051600.76193737
55TNF signaling pathway_Homo sapiens_hsa046680.75370030
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.75271758
57Ether lipid metabolism_Homo sapiens_hsa005650.73355109
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.72564926
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71350039
60Tryptophan metabolism_Homo sapiens_hsa003800.70732054
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70434706
62Allograft rejection_Homo sapiens_hsa053300.69635139
63Fatty acid degradation_Homo sapiens_hsa000710.68962015
64Glutathione metabolism_Homo sapiens_hsa004800.68932411
65Pancreatic secretion_Homo sapiens_hsa049720.66941109
66Autoimmune thyroid disease_Homo sapiens_hsa053200.66013327
67Tight junction_Homo sapiens_hsa045300.65531565
68Insulin secretion_Homo sapiens_hsa049110.64594152
69Phenylalanine metabolism_Homo sapiens_hsa003600.61929766
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61662987
71Gastric acid secretion_Homo sapiens_hsa049710.61372226
72Arachidonic acid metabolism_Homo sapiens_hsa005900.59562780
73Propanoate metabolism_Homo sapiens_hsa006400.58570242
74Butanoate metabolism_Homo sapiens_hsa006500.58321279
75Oxidative phosphorylation_Homo sapiens_hsa001900.58227096
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57946234
77Fatty acid elongation_Homo sapiens_hsa000620.57673151
78Graft-versus-host disease_Homo sapiens_hsa053320.55963768
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.52605467
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51752707
81Tyrosine metabolism_Homo sapiens_hsa003500.51550646
82Salivary secretion_Homo sapiens_hsa049700.51476921
83Alzheimers disease_Homo sapiens_hsa050100.50722055
84Fatty acid biosynthesis_Homo sapiens_hsa000610.50288428
85Complement and coagulation cascades_Homo sapiens_hsa046100.49304802
86Leishmaniasis_Homo sapiens_hsa051400.49076181
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.47253698
88Influenza A_Homo sapiens_hsa051640.44971976
89Sphingolipid metabolism_Homo sapiens_hsa006000.44052533
90Renin secretion_Homo sapiens_hsa049240.42483574
91Pentose phosphate pathway_Homo sapiens_hsa000300.41651388
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40971253
93Thyroid hormone synthesis_Homo sapiens_hsa049180.38889690
94African trypanosomiasis_Homo sapiens_hsa051430.38293176
95Carbon metabolism_Homo sapiens_hsa012000.38085161
96Cardiac muscle contraction_Homo sapiens_hsa042600.37248984
97Type II diabetes mellitus_Homo sapiens_hsa049300.36807557
98Pyruvate metabolism_Homo sapiens_hsa006200.36522270
99Retinol metabolism_Homo sapiens_hsa008300.36122791
100Staphylococcus aureus infection_Homo sapiens_hsa051500.35583722
101Folate biosynthesis_Homo sapiens_hsa007900.33471869
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32917014
103Insulin resistance_Homo sapiens_hsa049310.32857758
104beta-Alanine metabolism_Homo sapiens_hsa004100.32019569
105Choline metabolism in cancer_Homo sapiens_hsa052310.28688077
106Dorso-ventral axis formation_Homo sapiens_hsa043200.27800685
107Bladder cancer_Homo sapiens_hsa052190.27725755
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27409123
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26889080
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26164426
111Glucagon signaling pathway_Homo sapiens_hsa049220.24883943
112Hematopoietic cell lineage_Homo sapiens_hsa046400.24381574
113Pancreatic cancer_Homo sapiens_hsa052120.23622580
114Vitamin B6 metabolism_Homo sapiens_hsa007500.22486526
115HIF-1 signaling pathway_Homo sapiens_hsa040660.21307604
116Other glycan degradation_Homo sapiens_hsa005110.21265054
117Antigen processing and presentation_Homo sapiens_hsa046120.20989451
118Vibrio cholerae infection_Homo sapiens_hsa051100.20287526
119Adherens junction_Homo sapiens_hsa045200.19194539
120Metabolic pathways_Homo sapiens_hsa011000.18771666
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.16512588
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15649026
123Parkinsons disease_Homo sapiens_hsa050120.15355995
124Cocaine addiction_Homo sapiens_hsa050300.15170293
125Apoptosis_Homo sapiens_hsa042100.15032347
126Ovarian steroidogenesis_Homo sapiens_hsa049130.14660585
127Osteoclast differentiation_Homo sapiens_hsa043800.14238433
128Thyroid cancer_Homo sapiens_hsa052160.14031470
129Collecting duct acid secretion_Homo sapiens_hsa049660.10661417
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09063242
131Rheumatoid arthritis_Homo sapiens_hsa053230.08496953
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.08415027
133Amphetamine addiction_Homo sapiens_hsa050310.08128461
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08117080
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.07443483
136Serotonergic synapse_Homo sapiens_hsa047260.06465891

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