FAM3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)9.19950686
2rhodopsin mediated signaling pathway (GO:0016056)8.68358476
3retinal cone cell development (GO:0046549)8.48186924
4photoreceptor cell development (GO:0042461)6.11129396
5eye photoreceptor cell development (GO:0042462)5.90901848
6Arp2/3 complex-mediated actin nucleation (GO:0034314)5.57105007
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.39831912
8Golgi transport vesicle coating (GO:0048200)4.97657375
9COPI coating of Golgi vesicle (GO:0048205)4.97657375
10sequestering of actin monomers (GO:0042989)4.91317384
11phototransduction, visible light (GO:0007603)4.90512237
12phototransduction (GO:0007602)4.89551284
13keratinocyte proliferation (GO:0043616)4.83753683
14positive regulation of guanylate cyclase activity (GO:0031284)4.74977793
15photoreceptor cell maintenance (GO:0045494)4.70744496
16GMP metabolic process (GO:0046037)4.68853837
17hemidesmosome assembly (GO:0031581)4.68542151
18actin nucleation (GO:0045010)4.49427054
19detection of visible light (GO:0009584)4.45204878
20detection of light stimulus (GO:0009583)4.42868197
21desmosome organization (GO:0002934)4.39238118
22skin morphogenesis (GO:0043589)4.23456363
23positive regulation of macrophage differentiation (GO:0045651)3.99141706
24regulation of guanylate cyclase activity (GO:0031282)3.94528446
25retinal rod cell development (GO:0046548)3.92047517
26dermatan sulfate metabolic process (GO:0030205)3.91398018
27detection of light stimulus involved in sensory perception (GO:0050962)3.88475385
28detection of light stimulus involved in visual perception (GO:0050908)3.88475385
29cellular response to light stimulus (GO:0071482)3.84237907
30regulation of T cell tolerance induction (GO:0002664)3.79083640
31positive regulation of lamellipodium assembly (GO:0010592)3.78598308
32visual perception (GO:0007601)3.78109953
33sodium ion export (GO:0071436)3.76838104
34negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.74882191
35sensory perception of light stimulus (GO:0050953)3.73491814
36regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.67028572
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62950902
38glutamate secretion (GO:0014047)3.61419803
39dermatan sulfate biosynthetic process (GO:0030208)3.59257434
40cellular potassium ion homeostasis (GO:0030007)3.56785522
41protein-chromophore linkage (GO:0018298)3.48431509
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.48050525
43hepatocyte apoptotic process (GO:0097284)3.45026867
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.37373377
45cell morphogenesis involved in neuron differentiation (GO:0048667)3.35154167
46positive regulation of glycoprotein metabolic process (GO:1903020)3.30091803
47positive regulation of glycoprotein biosynthetic process (GO:0010560)3.27853175
48barbed-end actin filament capping (GO:0051016)3.25107984
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.23817057
50regulation of transforming growth factor beta2 production (GO:0032909)3.23269654
51negative regulation of fatty acid transport (GO:2000192)3.19289222
52positive regulation of lamellipodium organization (GO:1902745)3.17560292
53COPII vesicle coating (GO:0048208)3.15792278
54DNA deamination (GO:0045006)3.10718095
55protein localization to endosome (GO:0036010)3.10507756
56angiotensin maturation (GO:0002003)3.03703560
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03617960
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03617960
59regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.01384222
60pattern specification involved in kidney development (GO:0061004)3.01372856
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99563582
62regulation of bile acid biosynthetic process (GO:0070857)2.98656604
63regulation of penile erection (GO:0060405)2.97905698
64regulation of macrophage differentiation (GO:0045649)2.95715478
65lung vasculature development (GO:0060426)2.94983432
66detection of external stimulus (GO:0009581)2.94855437
67phagocytosis, engulfment (GO:0006911)2.94803481
68vesicle coating (GO:0006901)2.91933123
69positive regulation of pseudopodium assembly (GO:0031274)2.91615184
70negative regulation of chondrocyte differentiation (GO:0032331)2.90609758
71detection of abiotic stimulus (GO:0009582)2.90341869
72activation of Rac GTPase activity (GO:0032863)2.88225250
73positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.88206710
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.88056080
75cellular protein complex localization (GO:0034629)2.85248392
76hypotonic response (GO:0006971)2.82713043
77omega-hydroxylase P450 pathway (GO:0097267)2.81019186
78regulation of transforming growth factor beta1 production (GO:0032908)2.80648027
79regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78686372
80cellular response to radiation (GO:0071478)2.78218325
81membrane budding (GO:0006900)2.76635202
82protein hydroxylation (GO:0018126)2.76334019
83antigen processing and presentation of endogenous antigen (GO:0019883)2.75263539
84mammary gland alveolus development (GO:0060749)2.74728343
85negative regulation of keratinocyte proliferation (GO:0010839)2.73073277
86regulation of B cell receptor signaling pathway (GO:0050855)2.70554631
87protein heterotrimerization (GO:0070208)2.69848007
88ER overload response (GO:0006983)2.68703182
89regulation of cGMP metabolic process (GO:0030823)2.68267249
90retina development in camera-type eye (GO:0060041)2.67388066
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67061203
92muscle cell migration (GO:0014812)2.66972747
93mammary gland epithelial cell proliferation (GO:0033598)2.65889037
94peptidyl-proline hydroxylation (GO:0019511)2.65086881
95regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61892002
96cellular response to vitamin D (GO:0071305)2.61535845
97NADH metabolic process (GO:0006734)2.61067912
98lymphocyte costimulation (GO:0031294)2.60285492
99regulation of T cell receptor signaling pathway (GO:0050856)2.59710436
100mesodermal cell differentiation (GO:0048333)2.59242904
101regulation of pseudopodium assembly (GO:0031272)2.56901598
102regulation of isotype switching to IgG isotypes (GO:0048302)2.55951272
103retina homeostasis (GO:0001895)2.55725990
104T cell costimulation (GO:0031295)2.55146487
105ribosome assembly (GO:0042255)2.55082354
106positive regulation of actin filament depolymerization (GO:0030836)2.54495855
107response to interleukin-15 (GO:0070672)2.53980958
108membrane invagination (GO:0010324)2.53758157
109negative regulation of receptor-mediated endocytosis (GO:0048261)2.52896079
110production of molecular mediator involved in inflammatory response (GO:0002532)2.52719600
111positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.52548384
112leukocyte aggregation (GO:0070486)2.52373000
113positive regulation of tolerance induction (GO:0002645)2.51450418
114cellular copper ion homeostasis (GO:0006878)2.51054918
115apical protein localization (GO:0045176)2.49873633
116notochord development (GO:0030903)2.47800003
117endothelial cell morphogenesis (GO:0001886)2.47279538
118regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47114681
119regulation of early endosome to late endosome transport (GO:2000641)2.46659678
120regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46430789
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46115548
122actin filament depolymerization (GO:0030042)2.44831965
123cell-substrate junction assembly (GO:0007044)2.44583068
124nucleoside diphosphate biosynthetic process (GO:0009133)2.44045039
125gap junction assembly (GO:0016264)2.43573181
126cell adhesion mediated by integrin (GO:0033627)2.43404201
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43262133
128epithelial cell-cell adhesion (GO:0090136)2.43192144
129negative regulation of DNA repair (GO:0045738)2.43074521
130regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42131296
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42005711
132regulation of chemokine secretion (GO:0090196)2.41939247
133phosphate ion transmembrane transport (GO:0035435)2.41573855
134asymmetric protein localization (GO:0008105)2.41464472
135mesenchymal-epithelial cell signaling (GO:0060638)2.41174476
136collagen fibril organization (GO:0030199)2.40582981
137cell differentiation involved in metanephros development (GO:0072202)2.40444434
138regulation of mitotic spindle organization (GO:0060236)2.40359781
139membrane raft organization (GO:0031579)2.39055734
140positive regulation of endothelial cell apoptotic process (GO:2000353)2.37464104
141germ cell migration (GO:0008354)2.37221089
142positive regulation of protein localization to plasma membrane (GO:1903078)2.36430252
143tight junction assembly (GO:0070830)2.36324057
144adaptation of signaling pathway (GO:0023058)2.35732821
145cell communication involved in cardiac conduction (GO:0086065)2.35179895
146regulation of defense response to virus by virus (GO:0050690)2.35031534
147mating behavior (GO:0007617)2.34879781
148localization within membrane (GO:0051668)2.34856233
149virion attachment to host cell (GO:0019062)2.34263933
150adhesion of symbiont to host cell (GO:0044650)2.34263933
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.33486766
152negative regulation of anoikis (GO:2000811)2.33034480
153eye photoreceptor cell differentiation (GO:0001754)2.32352519
154photoreceptor cell differentiation (GO:0046530)2.32352519
155regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.32333202
156chondrocyte proliferation (GO:0035988)2.32324660
157regulation of glucocorticoid metabolic process (GO:0031943)2.31519183
158establishment of integrated proviral latency (GO:0075713)2.31228927
159regulation of necroptotic process (GO:0060544)2.30603591
160negative regulation of phagocytosis (GO:0050765)2.30311602
161positive regulation of astrocyte differentiation (GO:0048711)2.30200807
162protein retention in ER lumen (GO:0006621)2.29554329
163morphogenesis of an endothelium (GO:0003159)2.29520585
164endothelial tube morphogenesis (GO:0061154)2.29520585
165negative regulation of osteoclast differentiation (GO:0045671)2.27540843
166negative thymic T cell selection (GO:0045060)2.27305340
167regulation of metalloenzyme activity (GO:0048552)2.27128367
168regulation of tolerance induction (GO:0002643)2.25473224
169positive regulation of cGMP biosynthetic process (GO:0030828)2.25147005
170regulation of Rac protein signal transduction (GO:0035020)2.24591544
171positive regulation of protein export from nucleus (GO:0046827)2.24164061
172positive regulation of chemokine secretion (GO:0090197)2.22764432
173cellular response to interleukin-15 (GO:0071350)2.22653436
174cell-cell junction assembly (GO:0007043)2.22101661
175T cell receptor signaling pathway (GO:0050852)2.21790500
176renal system process involved in regulation of blood volume (GO:0001977)2.21619018
177endocytic recycling (GO:0032456)2.21597552
178branching involved in mammary gland duct morphogenesis (GO:0060444)2.21415813
179positive regulation of gamma-delta T cell activation (GO:0046645)2.21302791
180cellular response to vitamin (GO:0071295)2.21137684
181regulation of proton transport (GO:0010155)2.21052150
182negative T cell selection (GO:0043383)2.19940089
183diterpenoid biosynthetic process (GO:0016102)2.18927329
184sphingomyelin metabolic process (GO:0006684)2.18758476
185negative regulation of protein localization to plasma membrane (GO:1903077)2.18488102
186chondroitin sulfate biosynthetic process (GO:0030206)2.17689843
187layer formation in cerebral cortex (GO:0021819)2.17689404
188hippo signaling (GO:0035329)2.17499961
189mast cell activation (GO:0045576)2.17383865
190cellular response to interferon-alpha (GO:0035457)2.17216281
191regulation of pigment cell differentiation (GO:0050932)2.16924284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.17363216
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.91583728
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.78528425
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61363849
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42682888
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.28374665
7AR_21909140_ChIP-Seq_LNCAP_Human3.02998625
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96008744
9RUNX_20019798_ChIP-Seq_JUKART_Human2.95295316
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.91216734
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46690919
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32718072
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25441149
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24096417
15MYB_26560356_Chip-Seq_TH2_Human2.21282407
16ZNF263_19887448_ChIP-Seq_K562_Human2.19690480
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.19407637
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10365500
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06404977
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05708284
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04760502
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00506942
23MYC_22102868_ChIP-Seq_BL_Human1.99239144
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98298693
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95514379
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.93011113
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88682787
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.87428766
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85752741
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85703489
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84689319
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.83936293
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.78487825
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77088355
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.76032862
36PU_27001747_Chip-Seq_BMDM_Mouse1.76006783
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74923190
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.74231250
39* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74079106
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73159516
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.71502457
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69116346
43MYB_26560356_Chip-Seq_TH1_Human1.68294844
44SPI1_23547873_ChIP-Seq_NB4_Human1.67611751
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.66542997
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66369540
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64944870
48AR_21572438_ChIP-Seq_LNCaP_Human1.61296020
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.57286049
50* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57013342
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.56806701
52MAF_26560356_Chip-Seq_TH1_Human1.56788374
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56673081
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.56087844
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55860078
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55779800
57* SOX2_20726797_ChIP-Seq_SW620_Human1.55562960
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.55014723
59CLOCK_20551151_ChIP-Seq_293T_Human1.52148293
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51382760
61ATF3_27146783_Chip-Seq_COLON_Human1.51332285
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.51224785
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46285714
64* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44481429
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43820458
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.43696989
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42273501
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41436990
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41436990
70VDR_24763502_ChIP-Seq_THP-1_Human1.40441048
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38734981
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36921165
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.36761622
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36154790
75UTX_26944678_Chip-Seq_JUKART_Human1.36151757
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35998081
77* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34974163
78ELK1_19687146_ChIP-ChIP_HELA_Human1.30851617
79* BRD4_25478319_ChIP-Seq_HGPS_Human1.30507104
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28198165
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24880911
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24406128
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23866400
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20507017
85* TP63_23658742_ChIP-Seq_EP156T_Human1.20173447
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.19831524
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17158935
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14647732
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13808280
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13442433
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12560037
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12306021
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09870170
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09630298
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09237380
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09062984
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07230685
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.07055774
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06797366
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05286183
101E2F7_22180533_ChIP-Seq_HELA_Human1.05203891
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03762682
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03740227
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03391478
105TCF7_22412390_ChIP-Seq_EML_Mouse1.03362300
106VDR_24787735_ChIP-Seq_THP-1_Human1.03087767
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03031045
108* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02359040
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02226428
110TP53_18474530_ChIP-ChIP_U2OS_Human1.01914295
111CJUN_26792858_Chip-Seq_BT549_Human1.01887855
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99943402
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99587723
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99106751
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96757599
116SPI1_23127762_ChIP-Seq_K562_Human0.96046243
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95840992
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95834824
119VDR_21846776_ChIP-Seq_THP-1_Human0.95380466
120GATA3_27048872_Chip-Seq_THYMUS_Human0.95340021
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.95159843
122* GATA6_25053715_ChIP-Seq_YYC3_Human0.94729374
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94600470
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93770648
125NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93228921
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92938625
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92938625
128GATA4_25053715_ChIP-Seq_YYC3_Human0.92615249
129MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91438982
130* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91240031
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.90340099
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90070712
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89008107
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88906956
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88404151
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88389981
137TP53_16413492_ChIP-PET_HCT116_Human0.87513540
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87104542
139* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86792011
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86692997
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86569906
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85562654
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85372527
144ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85260249
145KLF5_25053715_ChIP-Seq_YYC3_Human0.84993268
146TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84876930
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84567541
148RACK7_27058665_Chip-Seq_MCF-7_Human0.83721621
149EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83595523
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83415130
151EGR1_19032775_ChIP-ChIP_M12_Human0.83035718
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.82766797
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82724083
154KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82300708
155* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82000442
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81735952
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81637305
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81332265
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80619188
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79925942
161P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78476314
162SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78009711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.81389897
2MP0005551_abnormal_eye_electrophysiolog4.61520395
3MP0008438_abnormal_cutaneous_collagen3.83263445
4MP0005253_abnormal_eye_physiology3.35227088
5MP0009780_abnormal_chondrocyte_physiolo3.01648379
6MP0010234_abnormal_vibrissa_follicle3.01176180
7MP0006072_abnormal_retinal_apoptosis2.96536777
8MP0005360_urolithiasis2.45887605
9MP0002166_altered_tumor_susceptibility2.37517542
10MP0010352_gastrointestinal_tract_polyps2.32554881
11MP0003566_abnormal_cell_adhesion2.31314996
12MP0001835_abnormal_antigen_presentation2.30921553
13MP0003763_abnormal_thymus_physiology2.26514349
14MP0005257_abnormal_intraocular_pressure2.23226266
15MP0000762_abnormal_tongue_morphology2.18263956
16MP0003941_abnormal_skin_development2.15818671
17MP0004264_abnormal_extraembryonic_tissu1.92236142
18MP0003705_abnormal_hypodermis_morpholog1.89101380
19MP0002060_abnormal_skin_morphology1.88828412
20MP0002796_impaired_skin_barrier1.86987663
21MP0002006_tumorigenesis1.85570746
22MP0005195_abnormal_posterior_eye1.84598115
23MP0003300_gastrointestinal_ulcer1.79494076
24MP0005275_abnormal_skin_tensile1.79261577
25MP0003045_fibrosis1.77194694
26MP0009384_cardiac_valve_regurgitation1.76040205
27MP0005391_vision/eye_phenotype1.74732043
28MP0005023_abnormal_wound_healing1.73994678
29MP0010678_abnormal_skin_adnexa1.73829785
30MP0001324_abnormal_eye_pigmentation1.73756075
31MP0004270_analgesia1.73242678
32MP0005671_abnormal_response_to1.72049539
33MP0003279_aneurysm1.69754860
34MP0002877_abnormal_melanocyte_morpholog1.68401661
35MP0005076_abnormal_cell_differentiation1.67749792
36MP0002009_preneoplasia1.65410549
37MP0003183_abnormal_peptide_metabolism1.61748682
38MP0004859_abnormal_synaptic_plasticity1.61212867
39MP0005409_darkened_coat_color1.60123312
40MP0000537_abnormal_urethra_morphology1.59140034
41MP0002933_joint_inflammation1.54345084
42MP0005503_abnormal_tendon_morphology1.54263212
43MP0002896_abnormal_bone_mineralization1.54204080
44MP0000579_abnormal_nail_morphology1.52213681
45MP0005501_abnormal_skin_physiology1.49655134
46MP0001299_abnormal_eye_distance/1.44835812
47MP0009379_abnormal_foot_pigmentation1.42649643
48MP0002452_abnormal_antigen_presenting1.42641477
49MP0003329_amyloid_beta_deposits1.42342623
50MP0000566_synostosis1.38465955
51MP0005197_abnormal_uvea_morphology1.37932074
52MP0005171_absent_coat_pigmentation1.37461004
53MP0001666_abnormal_nutrient_absorption1.34960019
54MP0006054_spinal_hemorrhage1.34723965
55MP0001542_abnormal_bone_strength1.33749842
56MP0002420_abnormal_adaptive_immunity1.33096187
57MP0009697_abnormal_copulation1.31394253
58MP0005000_abnormal_immune_tolerance1.30117534
59MP0001819_abnormal_immune_cell1.29988404
60MP0001800_abnormal_humoral_immune1.29204331
61MP0003724_increased_susceptibility_to1.26569105
62MP0000685_abnormal_immune_system1.25474903
63MP0003868_abnormal_feces_composition1.24574102
64MP0008007_abnormal_cellular_replicative1.24175041
65MP0001188_hyperpigmentation1.23939532
66MP0009333_abnormal_splenocyte_physiolog1.23595562
67MP0010368_abnormal_lymphatic_system1.23101794
68MP0001958_emphysema1.22162594
69MP0002090_abnormal_vision1.20608741
70MP0000678_abnormal_parathyroid_gland1.19117993
71MP0001986_abnormal_taste_sensitivity1.18635308
72MP0008004_abnormal_stomach_pH1.16802899
73MP0010155_abnormal_intestine_physiology1.15637948
74MP0004185_abnormal_adipocyte_glucose1.14799332
75MP0001348_abnormal_lacrimal_gland1.14474427
76MP0009785_altered_susceptibility_to1.14435840
77MP0001790_abnormal_immune_system1.14082661
78MP0005387_immune_system_phenotype1.14082661
79MP0002148_abnormal_hypersensitivity_rea1.13679928
80MP0000858_altered_metastatic_potential1.13185417
81MP0001216_abnormal_epidermal_layer1.10870308
82MP0002405_respiratory_system_inflammati1.10021065
83MP0001849_ear_inflammation1.08874988
84MP0002419_abnormal_innate_immunity1.08653848
85MP0002168_other_aberrant_phenotype1.08471108
86MP0006082_CNS_inflammation1.07731457
87MP0002638_abnormal_pupillary_reflex1.07505902
88MP0001873_stomach_inflammation1.07245012
89MP0005508_abnormal_skeleton_morphology1.06729937
90MP0004272_abnormal_basement_membrane1.06582476
91MP0005085_abnormal_gallbladder_physiolo1.06236564
92MP0002723_abnormal_immune_serum1.05510978
93MP0000465_gastrointestinal_hemorrhage1.05062635
94MP0001533_abnormal_skeleton_physiology1.05018851
95MP0001919_abnormal_reproductive_system1.04727857
96MP0005310_abnormal_salivary_gland1.04313277
97MP0004019_abnormal_vitamin_homeostasis1.04031125
98MP0003091_abnormal_cell_migration1.03768657
99MP0005165_increased_susceptibility_to1.03177685
100MP0002398_abnormal_bone_marrow1.01985518
101MP0010771_integument_phenotype1.01565223
102MP0000462_abnormal_digestive_system1.00653036
103MP0003866_abnormal_defecation1.00300665
104MP0004782_abnormal_surfactant_physiolog0.99835446
105MP0003303_peritoneal_inflammation0.99796457
106MP0002998_abnormal_bone_remodeling0.98306002
107MP0003436_decreased_susceptibility_to0.97233190
108MP0000490_abnormal_crypts_of0.96980584
109MP0000467_abnormal_esophagus_morphology0.95963090
110MP0000689_abnormal_spleen_morphology0.95358070
111MP0004947_skin_inflammation0.95309568
112MP0003950_abnormal_plasma_membrane0.95140449
113MP0005084_abnormal_gallbladder_morpholo0.94543107
114MP0005058_abnormal_lysosome_morphology0.94321560
115MP0004883_abnormal_blood_vessel0.93647010
116MP0001881_abnormal_mammary_gland0.91694706
117MP0000716_abnormal_immune_system0.91227810
118MP0000013_abnormal_adipose_tissue0.90807324
119MP0005025_abnormal_response_to0.89992860
120MP0001764_abnormal_homeostasis0.89988520
121MP0004858_abnormal_nervous_system0.89095296
122MP0000767_abnormal_smooth_muscle0.88293459
123MP0003634_abnormal_glial_cell0.87967223
124MP0003075_altered_response_to0.86838164
125MP0001879_abnormal_lymphatic_vessel0.86172667
126MP0005164_abnormal_response_to0.86035961
127MP0004808_abnormal_hematopoietic_stem0.85719166
128MP0004957_abnormal_blastocyst_morpholog0.85701522
129MP0000733_abnormal_muscle_development0.84149732
130MP0002722_abnormal_immune_system0.83700615
131MP0001915_intracranial_hemorrhage0.83661651
132MP0000534_abnormal_ureter_morphology0.83176687
133MP0003943_abnormal_hepatobiliary_system0.81473298
134MP0005623_abnormal_meninges_morphology0.81221680
135MP0003795_abnormal_bone_structure0.81212101
136MP0009053_abnormal_anal_canal0.80870162
137MP0000627_abnormal_mammary_gland0.80703174
138MP0003453_abnormal_keratinocyte_physiol0.79916362
139MP0002098_abnormal_vibrissa_morphology0.79727836
140MP0003385_abnormal_body_wall0.79661040
141MP0005464_abnormal_platelet_physiology0.78824531
142MP0000432_abnormal_head_morphology0.78542603
143MP0005390_skeleton_phenotype0.78100849
144MP0002396_abnormal_hematopoietic_system0.77770258
145MP0000428_abnormal_craniofacial_morphol0.77678856
146MP0003283_abnormal_digestive_organ0.76954768
147MP0002697_abnormal_eye_size0.76368737
148MP0002233_abnormal_nose_morphology0.76273329
149MP0002089_abnormal_postnatal_growth/wei0.76107217
150MP0001346_abnormal_lacrimal_gland0.75009703
151MP0002234_abnormal_pharynx_morphology0.75002138
152MP0005666_abnormal_adipose_tissue0.74997966
153MP0000751_myopathy0.74877078
154MP0000003_abnormal_adipose_tissue0.74628836
155MP0002177_abnormal_outer_ear0.72527810
156MP0004134_abnormal_chest_morphology0.71891566
157MP0001502_abnormal_circadian_rhythm0.70675389
158MP0003755_abnormal_palate_morphology0.69266202
159MP0000377_abnormal_hair_follicle0.68115940
160MP0003191_abnormal_cellular_cholesterol0.67651230
161MP0001730_embryonic_growth_arrest0.66429250
162MP0005621_abnormal_cell_physiology0.66114728
163MP0000163_abnormal_cartilage_morphology0.65035653
164MP0005375_adipose_tissue_phenotype0.64813752
165MP0001340_abnormal_eyelid_morphology0.63694685
166MP0003123_paternal_imprinting0.62451117
167MP0000350_abnormal_cell_proliferation0.60984091
168MP0000681_abnormal_thyroid_gland0.59950875
169MP0003937_abnormal_limbs/digits/tail_de0.59299720
170MP0001501_abnormal_sleep_pattern0.58779478
171MP0000477_abnormal_intestine_morphology0.57940811
172MP0003890_abnormal_embryonic-extraembry0.57700484

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.82800216
2Bony spicule pigmentary retinopathy (HP:0007737)7.25742060
3Absent rod-and cone-mediated responses on ERG (HP:0007688)6.90904984
4Abnormal rod and cone electroretinograms (HP:0008323)6.48633175
5Pigmentary retinal degeneration (HP:0001146)6.34509791
6Chorioretinal atrophy (HP:0000533)5.97307344
7Attenuation of retinal blood vessels (HP:0007843)4.91923866
8Dyschromatopsia (HP:0007641)4.39290432
9Pendular nystagmus (HP:0012043)4.34116542
10Protrusio acetabuli (HP:0003179)4.23546011
11Increased corneal curvature (HP:0100692)3.71284587
12Keratoconus (HP:0000563)3.71284587
13Abnormality of macular pigmentation (HP:0008002)3.54350171
14Scotoma (HP:0000575)3.50456204
15Photophobia (HP:0000613)3.42930287
16Aortic dissection (HP:0002647)3.36332335
17Right ventricular cardiomyopathy (HP:0011663)3.30180516
18Abolished electroretinogram (ERG) (HP:0000550)3.29830077
19Vitreoretinal degeneration (HP:0000655)3.27493932
20Insomnia (HP:0100785)3.17193486
21Type II diabetes mellitus (HP:0005978)3.15459752
22Cervical subluxation (HP:0003308)3.13681002
23Central scotoma (HP:0000603)3.09070893
24Termporal pattern (HP:0011008)3.03293586
25Insidious onset (HP:0003587)3.03293586
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96492651
27Premature rupture of membranes (HP:0001788)2.96371198
28Neurofibrillary tangles (HP:0002185)2.94896596
29Interstitial pulmonary disease (HP:0006530)2.82476703
30Decreased central vision (HP:0007663)2.80145166
31Macular degeneration (HP:0000608)2.76507815
32Ankyloglossia (HP:0010296)2.68040641
33Severe visual impairment (HP:0001141)2.65722197
34Onycholysis (HP:0001806)2.61328223
35Alopecia of scalp (HP:0002293)2.59767652
36Broad face (HP:0000283)2.59582192
37Pterygium (HP:0001059)2.59487298
38Atrophic scars (HP:0001075)2.59470440
39Abnormality of proline metabolism (HP:0010907)2.59359532
40Hydroxyprolinuria (HP:0003080)2.59359532
41Biconcave vertebral bodies (HP:0004586)2.53946481
42Vertebral arch anomaly (HP:0008438)2.50996679
43Bladder diverticulum (HP:0000015)2.48303661
44Vascular tortuosity (HP:0004948)2.44669423
45Aortic aneurysm (HP:0004942)2.43367291
46Retinitis pigmentosa (HP:0000510)2.41735139
47Vertebral compression fractures (HP:0002953)2.41314971
48Syringomyelia (HP:0003396)2.40615131
49Spinal cord lesions (HP:0100561)2.40615131
50Choroideremia (HP:0001139)2.38347080
51Arterial tortuosity (HP:0005116)2.38123000
52Cone-rod dystrophy (HP:0000548)2.38021372
53Abnormality of oral frenula (HP:0000190)2.37770559
54Cerebral inclusion bodies (HP:0100314)2.35896839
55Milia (HP:0001056)2.32072406
56Confusion (HP:0001289)2.31262675
57Pili torti (HP:0003777)2.30083768
58Distal upper limb amyotrophy (HP:0007149)2.28304264
59Upper limb amyotrophy (HP:0009129)2.28304264
60Focal segmental glomerulosclerosis (HP:0000097)2.26780962
61Striae distensae (HP:0001065)2.26177678
62Hyperparathyroidism (HP:0000843)2.23370733
63Aortic regurgitation (HP:0001659)2.22469321
64IgM deficiency (HP:0002850)2.21052508
65Elevated erythrocyte sedimentation rate (HP:0003565)2.20758687
66Dysostosis multiplex (HP:0000943)2.20331952
67Soft skin (HP:0000977)2.19440694
68Abnormality of the gastric mucosa (HP:0004295)2.18904205
69Ankle contracture (HP:0006466)2.17320459
70Neonatal short-limb short stature (HP:0008921)2.15717836
71Increased IgM level (HP:0003496)2.13694397
72Action tremor (HP:0002345)2.11436053
73Dilatation of the ascending aorta (HP:0005111)2.11255328
74Posterior subcapsular cataract (HP:0007787)2.04007685
75Fragile skin (HP:0001030)2.03913028
76Constricted visual fields (HP:0001133)2.03350503
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03131765
78Eczematoid dermatitis (HP:0000976)2.02724584
79Fragile nails (HP:0001808)2.02488824
80Hyperextensible skin (HP:0000974)2.00775823
81Spondylolisthesis (HP:0003302)2.00626846
82Hand muscle atrophy (HP:0009130)2.00461050
83Lymphopenia (HP:0001888)1.99994667
84Popliteal pterygium (HP:0009756)1.99551538
85Polar cataract (HP:0010696)1.98197965
86Plantar hyperkeratosis (HP:0007556)1.96046644
87Cardiovascular calcification (HP:0011915)1.93757634
88Coronal craniosynostosis (HP:0004440)1.91869966
89Malnutrition (HP:0004395)1.91802470
90Cerebral aneurysm (HP:0004944)1.91093005
91Follicular hyperkeratosis (HP:0007502)1.88608174
92Diaphragmatic weakness (HP:0009113)1.85425012
93Mildly elevated creatine phosphokinase (HP:0008180)1.84665939
94Ridged nail (HP:0001807)1.84590413
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.83202243
96Glomerulosclerosis (HP:0000096)1.83104873
97Aplasia involving bones of the upper limbs (HP:0009823)1.82404353
98Aplasia of the phalanges of the hand (HP:0009802)1.82404353
99Aplasia involving bones of the extremities (HP:0009825)1.82404353
100Genu recurvatum (HP:0002816)1.81809387
101Agammaglobulinemia (HP:0004432)1.81308457
102Thin skin (HP:0000963)1.80844200
103Subacute progressive viral hepatitis (HP:0006572)1.80371961
104Spinal rigidity (HP:0003306)1.79545296
105Unilateral renal agenesis (HP:0000122)1.78768118
106Hypercortisolism (HP:0001578)1.78764109
107Hoarse voice (HP:0001609)1.78201140
108Hyperacusis (HP:0010780)1.77455537
109Joint stiffness (HP:0001387)1.77347711
110Atrioventricular block (HP:0001678)1.76655244
111Abnormal glucose tolerance (HP:0001952)1.76096734
112Selective tooth agenesis (HP:0001592)1.75673376
113Shallow orbits (HP:0000586)1.75668319
114Conjugated hyperbilirubinemia (HP:0002908)1.75175525
115Glucose intolerance (HP:0000833)1.74856803
116Trismus (HP:0000211)1.74141359
117Hematochezia (HP:0002573)1.73768633
118Blue sclerae (HP:0000592)1.72439912
119Chronic mucocutaneous candidiasis (HP:0002728)1.72116772
120Recurrent cutaneous fungal infections (HP:0011370)1.72116772
121Palpitations (HP:0001962)1.72059809
122Spinal cord compression (HP:0002176)1.71469874
123Microglossia (HP:0000171)1.70345785
124Recurrent bronchitis (HP:0002837)1.70223321
125Vascular calcification (HP:0004934)1.69822220
126Amniotic constriction ring (HP:0009775)1.69729116
127Abnormality of placental membranes (HP:0011409)1.69729116
128Flared iliac wings (HP:0002869)1.68766185
129Myositis (HP:0100614)1.68152693
130Increased density of long bones (HP:0006392)1.66261178
131Axonal loss (HP:0003447)1.64591311
132Radial bowing (HP:0002986)1.63971528
133Peritonitis (HP:0002586)1.63909424
134Gastrointestinal stroma tumor (HP:0100723)1.63895262
135Hypercalcemia (HP:0003072)1.63864647
136Mitral regurgitation (HP:0001653)1.63480711
137Symptomatic seizures (HP:0011145)1.63069285
138Abnormality of the distal phalanges of the toes (HP:0010182)1.62959226
139Hypoglycemic seizures (HP:0002173)1.62687202
140IgA deficiency (HP:0002720)1.62528741
141Mitral valve prolapse (HP:0001634)1.62519878
142Abnormality of dentin (HP:0010299)1.62488021
143Pustule (HP:0200039)1.62298713
144Wide nasal bridge (HP:0000431)1.62016648
145Multiple lipomas (HP:0001012)1.61273025
146Hyperphosphatemia (HP:0002905)1.61216450
147Hyperactive renin-angiotensin system (HP:0000841)1.60769861
148Lower limb amyotrophy (HP:0007210)1.60339204
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.59559984
150Arnold-Chiari malformation (HP:0002308)1.59366347
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.58576351
152Osteolytic defects of the hand bones (HP:0009699)1.58576351
153Hypotension (HP:0002615)1.58428451
154Chronic diarrhea (HP:0002028)1.57878081
155Mitral stenosis (HP:0001718)1.57823787
156IgG deficiency (HP:0004315)1.57380829
157Micronodular cirrhosis (HP:0001413)1.56805472
158Hypoplasia of dental enamel (HP:0006297)1.56397634
159Abnormality of the intrinsic pathway (HP:0010989)1.56312498
160Overriding aorta (HP:0002623)1.55769230
161Short nail (HP:0001799)1.55196687
162Growth hormone excess (HP:0000845)1.52418060
163Abnormal platelet volume (HP:0011876)1.51973943
164Reduced subcutaneous adipose tissue (HP:0003758)1.49791711
165Asymmetry of the thorax (HP:0001555)1.48823902
166Recurrent fungal infections (HP:0002841)1.48344305
167Overgrowth (HP:0001548)1.45952942
168Wormian bones (HP:0002645)1.43983604
169Viral hepatitis (HP:0006562)1.42834630
170Increased mean platelet volume (HP:0011877)1.41992921
171Recurrent abscess formation (HP:0002722)1.41829471
172Decreased skull ossification (HP:0004331)1.41793592
173Degeneration of anterior horn cells (HP:0002398)1.41212393
174Abnormality of the anterior horn cell (HP:0006802)1.41212393
175Hypergammaglobulinemia (HP:0010702)1.41198957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.65389680
2FRK3.62262207
3LATS23.28540884
4SCYL23.20230370
5MET3.17716620
6TXK2.65213639
7GRK12.63155626
8NME22.57049503
9MAP3K92.55906460
10PIK3CA2.55902092
11TGFBR22.53268834
12DDR22.50570365
13NTRK12.32048307
14ZAP702.30126214
15MAP4K12.16014465
16NLK2.05060594
17KDR2.00160150
18PTK21.90370394
19STK101.86450550
20TESK21.84754910
21ARAF1.77701801
22SIK11.75047410
23TESK11.74062906
24EPHA41.73548081
25CASK1.73205459
26STK391.69657872
27STK241.64094946
28EPHB21.62536655
29ERBB41.57892831
30PBK1.54581168
31JAK31.51141875
32TEC1.50416674
33RPS6KA41.48874103
34BCR1.48826223
35FGFR31.47917845
36STK38L1.46374685
37NEK91.42452736
38EPHA21.40132690
39JAK11.35314269
40KIT1.33668390
41EIF2AK31.29427498
42CSK1.28227050
43PKN21.25982126
44ERBB31.24866531
45MAP3K141.23988668
46IKBKE1.23741044
47MKNK11.18045883
48STK31.17952902
49PIM21.13231229
50ROCK21.12140726
51MYLK1.06969906
52EIF2AK21.05084049
53TNIK1.03481959
54ERN11.03119202
55PLK21.01975262
56MKNK21.00877865
57PDGFRB0.99704771
58KSR10.99266810
59MOS0.96408245
60FES0.96099090
61BLK0.93427205
62LCK0.91674495
63MATK0.90946083
64ADRBK10.89786398
65CDK80.89681922
66LIMK10.89188990
67RIPK10.88355751
68MST1R0.87391828
69DMPK0.86573498
70TTK0.86402508
71TLK10.86100404
72BRAF0.84091178
73LYN0.82802216
74YES10.82467806
75PAK40.82253390
76KSR20.81557184
77TSSK60.81218864
78PNCK0.77972670
79CHUK0.77953148
80MAP3K130.76270650
81LRRK20.75504711
82PRPF4B0.75205529
83BMX0.74181596
84PIM10.73717752
85IKBKB0.73646880
86CSF1R0.73592078
87TBK10.73504101
88CAMKK20.71789437
89PRKG20.70874566
90NEK10.69948564
91DAPK10.69189713
92SYK0.68947419
93PRKD20.67391759
94MAP3K20.67278883
95CLK10.67181630
96MAP3K100.66250206
97AKT30.64827787
98FGFR40.63746640
99CAMKK10.63722160
100INSR0.63563862
101TYK20.63300838
102PRKCH0.62301401
103PDGFRA0.59742028
104TGFBR10.58892219
105BTK0.58339057
106EIF2AK10.57354752
107BMPR20.57033007
108ABL20.56815370
109PAK20.56123761
110FGFR10.55577487
111GRK60.54035139
112FER0.53608817
113AKT20.52808278
114PRKCI0.52218354
115NTRK30.51545635
116CDK180.51441321
117SGK20.50093556
118CDK60.49956135
119PAK60.49465570
120NEK60.48938978
121CAMK2G0.48572529
122ITK0.48150720
123CAMK2B0.47834338
124MAP3K80.47813846
125STK380.46798503
126MAP3K110.46643452
127GRK70.46274623
128MINK10.45291803
129CDK150.45071681
130PRKCE0.44952617
131PLK30.44632750
132LATS10.44418031
133JAK20.43889199
134UHMK10.43506657
135TNK20.42714191
136CDK11A0.42478394
137NUAK10.42282100
138BRSK10.41795372
139CDK140.41666082
140BUB10.41630325
141SIK30.41614731
142ICK0.41319573
143ACVR1B0.41036158
144MAPK150.40247911
145TRIM280.39895017
146TYRO30.39150402
147MAPK70.38115073
148GRK50.36878167
149ROCK10.36728733
150LMTK20.36474477
151CAMK2D0.36373909
152MST40.35770909
153WNK40.35382144
154PHKG20.34308153
155PHKG10.34308153
156ALK0.33927369
157CDK50.32453591
158WNK10.31439461
159IRAK30.26971991
160CDK120.26139410
161MAPK100.25856914

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.42178979
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27136787
3Primary immunodeficiency_Homo sapiens_hsa053402.22108335
4Vitamin B6 metabolism_Homo sapiens_hsa007502.12229268
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94491604
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.92294529
7Renin-angiotensin system_Homo sapiens_hsa046141.88568258
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77551507
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73194233
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71589901
11Sulfur metabolism_Homo sapiens_hsa009201.58121698
12Mineral absorption_Homo sapiens_hsa049781.58094985
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.56886849
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55035243
15Thyroid cancer_Homo sapiens_hsa052161.47536695
16Long-term potentiation_Homo sapiens_hsa047201.46826643
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44047691
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41254052
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40500277
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36742350
21Antigen processing and presentation_Homo sapiens_hsa046121.35244734
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34735882
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32506497
24Amphetamine addiction_Homo sapiens_hsa050311.31415396
25Arginine biosynthesis_Homo sapiens_hsa002201.31129304
26Leishmaniasis_Homo sapiens_hsa051401.31085891
27T cell receptor signaling pathway_Homo sapiens_hsa046601.29439221
28Tight junction_Homo sapiens_hsa045301.28617789
29Circadian rhythm_Homo sapiens_hsa047101.28425647
30Other glycan degradation_Homo sapiens_hsa005111.26652672
31Hematopoietic cell lineage_Homo sapiens_hsa046401.24640382
32Shigellosis_Homo sapiens_hsa051311.23274960
33N-Glycan biosynthesis_Homo sapiens_hsa005101.23261898
34Thyroid hormone synthesis_Homo sapiens_hsa049181.21153289
35Viral myocarditis_Homo sapiens_hsa054161.19337088
36Adherens junction_Homo sapiens_hsa045201.18948441
37Melanogenesis_Homo sapiens_hsa049161.17984691
38Arginine and proline metabolism_Homo sapiens_hsa003301.17890399
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15937401
40Protein export_Homo sapiens_hsa030601.15905509
41Folate biosynthesis_Homo sapiens_hsa007901.15673280
42Salmonella infection_Homo sapiens_hsa051321.13964525
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13365850
44Bile secretion_Homo sapiens_hsa049761.11748456
45Vitamin digestion and absorption_Homo sapiens_hsa049771.10975242
46ECM-receptor interaction_Homo sapiens_hsa045121.10273946
47Sphingolipid metabolism_Homo sapiens_hsa006001.08723703
48Colorectal cancer_Homo sapiens_hsa052101.07867923
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07221396
50Renal cell carcinoma_Homo sapiens_hsa052111.07154850
51Starch and sucrose metabolism_Homo sapiens_hsa005001.06543734
52Measles_Homo sapiens_hsa051621.04520077
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.04217580
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04070380
55Cocaine addiction_Homo sapiens_hsa050301.02576246
56Malaria_Homo sapiens_hsa051441.01552987
57Fat digestion and absorption_Homo sapiens_hsa049750.99924236
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98467457
59Focal adhesion_Homo sapiens_hsa045100.98282042
60Synaptic vesicle cycle_Homo sapiens_hsa047210.97939137
61Histidine metabolism_Homo sapiens_hsa003400.96720808
62Toxoplasmosis_Homo sapiens_hsa051450.95166350
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.94455465
64Platelet activation_Homo sapiens_hsa046110.93776445
65ErbB signaling pathway_Homo sapiens_hsa040120.93306121
66Pancreatic cancer_Homo sapiens_hsa052120.93025224
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91825291
68Chronic myeloid leukemia_Homo sapiens_hsa052200.90584785
69Insulin secretion_Homo sapiens_hsa049110.89904123
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89137566
71Fructose and mannose metabolism_Homo sapiens_hsa000510.88960425
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88626372
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.86419168
74Allograft rejection_Homo sapiens_hsa053300.85545106
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84025012
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83306853
77Osteoclast differentiation_Homo sapiens_hsa043800.82367961
78B cell receptor signaling pathway_Homo sapiens_hsa046620.82335205
79Hepatitis B_Homo sapiens_hsa051610.81320541
80Dopaminergic synapse_Homo sapiens_hsa047280.79999032
81Asthma_Homo sapiens_hsa053100.79832014
82Biosynthesis of amino acids_Homo sapiens_hsa012300.79608378
83Fatty acid biosynthesis_Homo sapiens_hsa000610.78725244
84Phagosome_Homo sapiens_hsa041450.78456159
85Axon guidance_Homo sapiens_hsa043600.78025518
86Legionellosis_Homo sapiens_hsa051340.77519409
87Gap junction_Homo sapiens_hsa045400.76925606
88Proteoglycans in cancer_Homo sapiens_hsa052050.76816393
89Acute myeloid leukemia_Homo sapiens_hsa052210.75659771
90Endometrial cancer_Homo sapiens_hsa052130.75193939
91Pancreatic secretion_Homo sapiens_hsa049720.75039172
92Olfactory transduction_Homo sapiens_hsa047400.74671668
93Hedgehog signaling pathway_Homo sapiens_hsa043400.74490749
94Pentose phosphate pathway_Homo sapiens_hsa000300.73628206
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73267154
96p53 signaling pathway_Homo sapiens_hsa041150.72569700
97Estrogen signaling pathway_Homo sapiens_hsa049150.72400774
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.72083265
99Apoptosis_Homo sapiens_hsa042100.70910069
100Phenylalanine metabolism_Homo sapiens_hsa003600.70612224
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70400090
102Chemokine signaling pathway_Homo sapiens_hsa040620.69283826
103TGF-beta signaling pathway_Homo sapiens_hsa043500.69195444
104Vibrio cholerae infection_Homo sapiens_hsa051100.69004991
105HTLV-I infection_Homo sapiens_hsa051660.68715556
106Renin secretion_Homo sapiens_hsa049240.68704370
107Small cell lung cancer_Homo sapiens_hsa052220.67809863
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67576267
109Dilated cardiomyopathy_Homo sapiens_hsa054140.67436565
110Pertussis_Homo sapiens_hsa051330.66441096
111Tuberculosis_Homo sapiens_hsa051520.65677858
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.65037369
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64166294
114Hippo signaling pathway_Homo sapiens_hsa043900.63822964
115TNF signaling pathway_Homo sapiens_hsa046680.63421807
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63103206
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63000716
118Prolactin signaling pathway_Homo sapiens_hsa049170.62997664
119Glucagon signaling pathway_Homo sapiens_hsa049220.61994001
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61463504
121Prostate cancer_Homo sapiens_hsa052150.61271790
122PPAR signaling pathway_Homo sapiens_hsa033200.60937677
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60414710
124Endocytosis_Homo sapiens_hsa041440.58357318
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58277533
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57933530
127Rheumatoid arthritis_Homo sapiens_hsa053230.57532627
128Gastric acid secretion_Homo sapiens_hsa049710.56302481
129Glioma_Homo sapiens_hsa052140.53469199
130Glutamatergic synapse_Homo sapiens_hsa047240.53303296
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52510487
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52446854
133Basal cell carcinoma_Homo sapiens_hsa052170.51858454
134Pathways in cancer_Homo sapiens_hsa052000.51426829
135Oocyte meiosis_Homo sapiens_hsa041140.51415053
136Prion diseases_Homo sapiens_hsa050200.51000192
137Herpes simplex infection_Homo sapiens_hsa051680.49577957
138Cholinergic synapse_Homo sapiens_hsa047250.49465969
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49302344
140AMPK signaling pathway_Homo sapiens_hsa041520.49005795
141Bladder cancer_Homo sapiens_hsa052190.48692595
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48304602
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48257022
144Melanoma_Homo sapiens_hsa052180.48216355
145Insulin signaling pathway_Homo sapiens_hsa049100.48103791
146Amoebiasis_Homo sapiens_hsa051460.47890021
147GnRH signaling pathway_Homo sapiens_hsa049120.46999107
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46909731
149MicroRNAs in cancer_Homo sapiens_hsa052060.46259725
150Graft-versus-host disease_Homo sapiens_hsa053320.46055501
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45705458
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.45645668
153Lysosome_Homo sapiens_hsa041420.45624720
154Viral carcinogenesis_Homo sapiens_hsa052030.43824663
155Non-small cell lung cancer_Homo sapiens_hsa052230.41888249
156Wnt signaling pathway_Homo sapiens_hsa043100.41875176
157Rap1 signaling pathway_Homo sapiens_hsa040150.40488718
158Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40273296
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38548815
160NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35379170
161Serotonergic synapse_Homo sapiens_hsa047260.35159786
162Galactose metabolism_Homo sapiens_hsa000520.34764175
163VEGF signaling pathway_Homo sapiens_hsa043700.34391546
164Protein digestion and absorption_Homo sapiens_hsa049740.33381535

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