FAM3C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.50601281
2Golgi transport vesicle coating (GO:0048200)6.50601281
3hemidesmosome assembly (GO:0031581)6.05204367
4cell adhesion mediated by integrin (GO:0033627)5.49585922
5skin morphogenesis (GO:0043589)5.25194471
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.66748938
7desmosome organization (GO:0002934)4.35157655
8protein localization to endosome (GO:0036010)4.29587300
9mammary gland epithelial cell proliferation (GO:0033598)4.07581130
10protein retention in ER lumen (GO:0006621)3.99594171
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.88065275
12cell-substrate junction assembly (GO:0007044)3.84319075
13nuclear pore complex assembly (GO:0051292)3.76194425
14mesodermal cell differentiation (GO:0048333)3.72001517
15hypotonic response (GO:0006971)3.69914471
16ER overload response (GO:0006983)3.69751735
17membrane raft organization (GO:0031579)3.44826288
18protein maturation by protein folding (GO:0022417)3.42537551
19endodermal cell differentiation (GO:0035987)3.38976563
20dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.38856666
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30055812
22ribosome assembly (GO:0042255)3.20493527
23regulation of transforming growth factor beta2 production (GO:0032909)3.20381466
24protein hydroxylation (GO:0018126)3.16964649
25keratinocyte proliferation (GO:0043616)3.15763745
26vesicle coating (GO:0006901)3.14726144
27endoplasmic reticulum unfolded protein response (GO:0030968)3.11046157
28regulation of translational termination (GO:0006449)3.08958343
29negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.05717092
30mitotic chromosome condensation (GO:0007076)3.02164165
31COPII vesicle coating (GO:0048208)3.02092007
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.01835904
33membrane protein ectodomain proteolysis (GO:0006509)2.99023959
34ER-nucleus signaling pathway (GO:0006984)2.95821407
35protein localization to microtubule (GO:0035372)2.95294119
36epithelial cell-cell adhesion (GO:0090136)2.95211333
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.95118549
38positive regulation of nuclease activity (GO:0032075)2.94516058
39branching involved in mammary gland duct morphogenesis (GO:0060444)2.94365696
40nuclear pore organization (GO:0006999)2.92836811
41mitotic cytokinesis (GO:0000281)2.92456714
42negative regulation of keratinocyte proliferation (GO:0010839)2.91231051
43cellular response to unfolded protein (GO:0034620)2.90922780
44wound healing, spreading of epidermal cells (GO:0035313)2.90885205
45muscle cell migration (GO:0014812)2.89369897
46pore complex assembly (GO:0046931)2.87753189
47establishment of integrated proviral latency (GO:0075713)2.83747117
48cellular copper ion homeostasis (GO:0006878)2.81757208
49regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.80214398
50substrate-dependent cell migration (GO:0006929)2.78313261
51regulation of nuclease activity (GO:0032069)2.75669817
52cytoskeleton-dependent cytokinesis (GO:0061640)2.74419770
53negative regulation of chondrocyte differentiation (GO:0032331)2.73595407
54peptidyl-proline hydroxylation (GO:0019511)2.73280765
55negative regulation of anoikis (GO:2000811)2.73156710
56focal adhesion assembly (GO:0048041)2.72321798
57cell-substrate adherens junction assembly (GO:0007045)2.72321798
58barbed-end actin filament capping (GO:0051016)2.71203341
59wound healing, spreading of cells (GO:0044319)2.70836547
60positive regulation of endothelial cell apoptotic process (GO:2000353)2.70090227
61regulation of RNA export from nucleus (GO:0046831)2.68914919
62regulation of nucleobase-containing compound transport (GO:0032239)2.66292329
63heterochromatin organization (GO:0070828)2.66082810
64cellular response to vitamin D (GO:0071305)2.65844108
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.63465011
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62324891
67basement membrane organization (GO:0071711)2.62252925
68cellular response to topologically incorrect protein (GO:0035967)2.61284381
69activation of Rac GTPase activity (GO:0032863)2.60799135
70histone H2B ubiquitination (GO:0033523)2.60555146
71adherens junction assembly (GO:0034333)2.60377513
72regulation of transforming growth factor beta1 production (GO:0032908)2.60286924
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.59893056
74positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57902088
75regulation of mitotic spindle organization (GO:0060236)2.55737444
76collagen fibril organization (GO:0030199)2.54744185
77endothelial cell morphogenesis (GO:0001886)2.54252773
78gap junction assembly (GO:0016264)2.53776042
79DNA unwinding involved in DNA replication (GO:0006268)2.53075143
80positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.52645215
81response to endoplasmic reticulum stress (GO:0034976)2.51021424
82establishment of viral latency (GO:0019043)2.50628451
83regulation of metalloenzyme activity (GO:0048552)2.50620874
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48704582
85localization within membrane (GO:0051668)2.46940171
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46884433
87positive regulation of p38MAPK cascade (GO:1900745)2.45124259
88trophoblast giant cell differentiation (GO:0060707)2.39032464
89positive regulation of osteoblast proliferation (GO:0033690)2.38959231
90diterpenoid biosynthetic process (GO:0016102)2.37561841
91response to unfolded protein (GO:0006986)2.36777212
92apoptotic cell clearance (GO:0043277)2.36740211
93regulation of translational fidelity (GO:0006450)2.36702924
94stress fiber assembly (GO:0043149)2.35613139
95positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.34720165
96formation of translation preinitiation complex (GO:0001731)2.34647490
97lung vasculature development (GO:0060426)2.33303794
98endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.32282351
99regulation of protein export from nucleus (GO:0046825)2.31819792
100hippo signaling (GO:0035329)2.31567469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.46834077
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.66282976
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37828529
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.32296353
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.30394481
6ZNF263_19887448_ChIP-Seq_K562_Human3.14442599
7E2F7_22180533_ChIP-Seq_HELA_Human3.07563625
8CLOCK_20551151_ChIP-Seq_293T_Human2.88214528
9AR_21909140_ChIP-Seq_LNCAP_Human2.61908283
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55422259
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.47354327
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.42904972
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.42904972
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.41470696
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.31471651
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16151976
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.11433312
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.10455603
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00529490
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.98648194
21ATF3_27146783_Chip-Seq_COLON_Human1.94094365
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88608094
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.85492144
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.85441877
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84029616
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80856709
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75247392
28HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.71832040
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.70698713
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67781818
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67020071
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65359698
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64006690
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57719704
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57712016
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57579012
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56593096
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.55960337
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54160126
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53760762
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50388387
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47000583
43KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46578772
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46522925
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46505205
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45129148
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.42591513
48MYC_22102868_ChIP-Seq_BL_Human1.42317949
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.40672332
50BRD4_25478319_ChIP-Seq_HGPS_Human1.40473895
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.39636784
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38282667
53RACK7_27058665_Chip-Seq_MCF-7_Human1.37160700
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35954879
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34457492
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30255003
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28622216
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27774074
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26973812
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25363418
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24365482
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23270779
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23179176
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23047524
65TP53_22127205_ChIP-Seq_IMR90_Human1.21829913
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20440109
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19532156
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19126336
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18688593
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18266244
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17413519
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16863158
73NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16441517
74TFEB_21752829_ChIP-Seq_HELA_Human1.15268478
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.14592135
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14069228
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13914157
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.12548582
79SOX2_20726797_ChIP-Seq_SW620_Human1.10060924
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09883257
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.09421141
82DCP1A_22483619_ChIP-Seq_HELA_Human1.08522078
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07580588
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.05662147
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04335454
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02498591
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02387244
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00413493
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99896177
90CJUN_26792858_Chip-Seq_BT549_Human0.98847331
91CHD1_26751641_Chip-Seq_LNCaP_Human0.96847233
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94344793
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94316769
94MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93609127
95GATA6_25053715_ChIP-Seq_YYC3_Human0.92701162
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92418865
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91816367
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.91464100
99MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91319855
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90889704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.53856571
2MP0002877_abnormal_melanocyte_morpholog4.22680554
3MP0003705_abnormal_hypodermis_morpholog4.02536832
4MP0003566_abnormal_cell_adhesion3.66833922
5MP0004272_abnormal_basement_membrane3.49532730
6MP0010234_abnormal_vibrissa_follicle3.18948464
7MP0005257_abnormal_intraocular_pressure2.92365625
8MP0010352_gastrointestinal_tract_polyps2.68895138
9MP0002060_abnormal_skin_morphology2.33594789
10MP0005623_abnormal_meninges_morphology2.29957666
11MP0005275_abnormal_skin_tensile2.18702503
12MP0003941_abnormal_skin_development2.13469966
13MP0005023_abnormal_wound_healing2.03556689
14MP0003091_abnormal_cell_migration1.80883350
15MP0000537_abnormal_urethra_morphology1.77650304
16MP0003950_abnormal_plasma_membrane1.77566154
17MP0002796_impaired_skin_barrier1.75136457
18MP0003453_abnormal_keratinocyte_physiol1.74690650
19MP0005076_abnormal_cell_differentiation1.70476908
20MP0005501_abnormal_skin_physiology1.69189585
21MP0005451_abnormal_body_composition1.67938985
22MP0000762_abnormal_tongue_morphology1.65099055
23MP0004957_abnormal_blastocyst_morpholog1.61923145
24MP0004185_abnormal_adipocyte_glucose1.60384146
25MP0001958_emphysema1.55018345
26MP0009053_abnormal_anal_canal1.50028586
27MP0001216_abnormal_epidermal_layer1.45443078
28MP0010368_abnormal_lymphatic_system1.41860613
29MP0001849_ear_inflammation1.41499613
30MP0000733_abnormal_muscle_development1.41233017
31MP0004264_abnormal_extraembryonic_tissu1.41163263
32MP0000467_abnormal_esophagus_morphology1.40485115
33MP0003693_abnormal_embryo_hatching1.35442990
34MP0000858_altered_metastatic_potential1.35414989
35MP0004233_abnormal_muscle_weight1.32718304
36MP0003279_aneurysm1.28623417
37MP0000579_abnormal_nail_morphology1.27809586
38MP0001348_abnormal_lacrimal_gland1.26220601
39MP0003111_abnormal_nucleus_morphology1.25347359
40MP0001243_abnormal_dermal_layer1.23047049
41MP0001730_embryonic_growth_arrest1.21654276
42MP0000627_abnormal_mammary_gland1.15558930
43MP0002896_abnormal_bone_mineralization1.15385585
44MP0003448_altered_tumor_morphology1.15287984
45MP0010771_integument_phenotype1.06966376
46MP0005621_abnormal_cell_physiology1.06847797
47MP0008007_abnormal_cellular_replicative1.06218549
48MP0005409_darkened_coat_color1.06162688
49MP0004947_skin_inflammation1.05787325
50MP0003191_abnormal_cellular_cholesterol1.04742006
51MP0008932_abnormal_embryonic_tissue1.04293644
52MP0001542_abnormal_bone_strength1.03430429
53MP0010678_abnormal_skin_adnexa1.02459840
54MP0002086_abnormal_extraembryonic_tissu1.02220326
55MP0001881_abnormal_mammary_gland1.01931250
56MP0000350_abnormal_cell_proliferation1.01426740
57MP0005165_increased_susceptibility_to0.99623939
58MP0001915_intracranial_hemorrhage0.99562579
59MP0009840_abnormal_foam_cell0.98178328
60MP0004858_abnormal_nervous_system0.95102133
61MP0003385_abnormal_body_wall0.94702871
62MP0004782_abnormal_surfactant_physiolog0.93068735
63MP0005508_abnormal_skeleton_morphology0.92737433
64MP0002098_abnormal_vibrissa_morphology0.92313433
65MP0000678_abnormal_parathyroid_gland0.91954333
66MP0006054_spinal_hemorrhage0.90399868
67MP0001727_abnormal_embryo_implantation0.89455007
68MP0005164_abnormal_response_to0.88612450
69MP0005197_abnormal_uvea_morphology0.87809380
70MP0002080_prenatal_lethality0.87646779
71MP0000377_abnormal_hair_follicle0.86824219
72MP0000767_abnormal_smooth_muscle0.85402427
73MP0003984_embryonic_growth_retardation0.85207388
74MP0000003_abnormal_adipose_tissue0.84888610
75MP0002089_abnormal_postnatal_growth/wei0.83983909
76MP0005503_abnormal_tendon_morphology0.83572889
77MP0005380_embryogenesis_phenotype0.82358272
78MP0001672_abnormal_embryogenesis/_devel0.82358272
79MP0005058_abnormal_lysosome_morphology0.82040669
80MP0010307_abnormal_tumor_latency0.81749320
81MP0003077_abnormal_cell_cycle0.80906621
82MP0002697_abnormal_eye_size0.79776072
83MP0005384_cellular_phenotype0.78708328
84MP0002088_abnormal_embryonic_growth/wei0.78239509
85MP0003329_amyloid_beta_deposits0.78085592
86MP0004808_abnormal_hematopoietic_stem0.77392151
87MP0004197_abnormal_fetal_growth/weight/0.76632258
88MP0005408_hypopigmentation0.76503776
89MP0000751_myopathy0.76261670
90MP0003315_abnormal_perineum_morphology0.75920205
91MP0002084_abnormal_developmental_patter0.74985279
92MP0005193_abnormal_anterior_eye0.74304823
93MP0009931_abnormal_skin_appearance0.74284991
94MP0000432_abnormal_head_morphology0.73948524
95MP0003221_abnormal_cardiomyocyte_apopto0.73412398
96MP0003300_gastrointestinal_ulcer0.72463000
97MP0002269_muscular_atrophy0.71992275
98MP0000013_abnormal_adipose_tissue0.71296112
99MP0000428_abnormal_craniofacial_morphol0.70055794
100MP0009780_abnormal_chondrocyte_physiolo0.69490257

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.44189726
2Protrusio acetabuli (HP:0003179)4.81062492
3Atrophic scars (HP:0001075)4.58123438
4Arterial tortuosity (HP:0005116)4.21922471
5Vascular tortuosity (HP:0004948)4.13256027
6Fragile skin (HP:0001030)3.52283208
7Aortic dissection (HP:0002647)3.24524335
8Hyperacusis (HP:0010780)3.08088269
9Vertebral compression fractures (HP:0002953)3.07915605
10Insomnia (HP:0100785)3.06244991
11Bladder diverticulum (HP:0000015)2.97695582
12Onycholysis (HP:0001806)2.81273539
13Osteolytic defects of the hand bones (HP:0009699)2.74523276
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.74523276
15Wormian bones (HP:0002645)2.72508055
16Abnormality of oral frenula (HP:0000190)2.71558122
17Vertebral arch anomaly (HP:0008438)2.70964438
18Ankle contracture (HP:0006466)2.67904906
19Spinal rigidity (HP:0003306)2.65418204
20Short nail (HP:0001799)2.63647006
21Right ventricular cardiomyopathy (HP:0011663)2.57696817
22Achilles tendon contracture (HP:0001771)2.57056429
23Milia (HP:0001056)2.53052768
24Follicular hyperkeratosis (HP:0007502)2.44569594
25Soft skin (HP:0000977)2.42077469
26Natal tooth (HP:0000695)2.40077150
27Spondylolisthesis (HP:0003302)2.39079538
28Fragile nails (HP:0001808)2.35780830
29Increased connective tissue (HP:0009025)2.32674939
30Ankyloglossia (HP:0010296)2.32643557
31Upper limb amyotrophy (HP:0009129)2.31030144
32Distal upper limb amyotrophy (HP:0007149)2.31030144
33Trismus (HP:0000211)2.28832634
34Abnormality of dentin (HP:0010299)2.28578909
35Selective tooth agenesis (HP:0001592)2.28436087
36Unilateral renal agenesis (HP:0000122)2.26570325
37Abnormality of the Achilles tendon (HP:0005109)2.25312309
38Reduced subcutaneous adipose tissue (HP:0003758)2.21353370
39Alopecia of scalp (HP:0002293)2.21218778
40Distal lower limb amyotrophy (HP:0008944)2.21147647
41Entropion (HP:0000621)2.17650613
42Dilatation of the ascending aorta (HP:0005111)2.17023743
43Overriding aorta (HP:0002623)2.16061797
44Ulnar bowing (HP:0003031)2.15196830
45Abnormality of the acetabulum (HP:0003170)2.13853913
46Elbow flexion contracture (HP:0002987)2.11053191
47Elfin facies (HP:0004428)2.08859348
48Aortic aneurysm (HP:0004942)2.07683876
49Nail dystrophy (HP:0008404)2.07587279
50Orthostatic hypotension (HP:0001278)2.05436566
51Termporal pattern (HP:0011008)2.03290238
52Insidious onset (HP:0003587)2.03290238
53Genu recurvatum (HP:0002816)2.03112745
54Flat acetabular roof (HP:0003180)2.03006824
55Advanced eruption of teeth (HP:0006288)2.02906418
56Neonatal short-limb short stature (HP:0008921)2.02501651
57Back pain (HP:0003418)2.00958717
58Plantar hyperkeratosis (HP:0007556)1.99973889
59Thick nail (HP:0001805)1.98888782
60Cerebral inclusion bodies (HP:0100314)1.98866158
61Abnormality of the distal phalanges of the toes (HP:0010182)1.98089166
62Thin skin (HP:0000963)1.95556649
63Blue sclerae (HP:0000592)1.94692008
64Renal duplication (HP:0000075)1.93829930
65Syringomyelia (HP:0003396)1.91563947
66Spinal cord lesions (HP:0100561)1.91563947
67Pterygium (HP:0001059)1.90395544
68Mitral valve prolapse (HP:0001634)1.90161526
69Ridged nail (HP:0001807)1.83780796
70Mildly elevated creatine phosphokinase (HP:0008180)1.83663830
71Hand muscle atrophy (HP:0009130)1.82619388
72Cervical subluxation (HP:0003308)1.81219775
73Cardiovascular calcification (HP:0011915)1.80509750
74Upper limb muscle weakness (HP:0003484)1.80439546
75Neurofibrillary tangles (HP:0002185)1.80400346
76Shallow orbits (HP:0000586)1.79531698
77Shoulder girdle muscle weakness (HP:0003547)1.79059565
78Joint laxity (HP:0001388)1.76827733
79Hyperextensible skin (HP:0000974)1.74817902
80Broad face (HP:0000283)1.73791348
81Cerebral aneurysm (HP:0004944)1.73644701
82Aplasia cutis congenita (HP:0001057)1.73216380
83Abnormal delivery (HP:0001787)1.72704684
84Difficulty climbing stairs (HP:0003551)1.72000006
85Microglossia (HP:0000171)1.71971957
86Mitral regurgitation (HP:0001653)1.71969594
87Deviation of the thumb (HP:0009603)1.71856657
88Pelvic girdle muscle weakness (HP:0003749)1.71756432
89Mitral stenosis (HP:0001718)1.71072751
90Focal segmental glomerulosclerosis (HP:0000097)1.70200739
91Breech presentation (HP:0001623)1.69292378
92Aneurysm (HP:0002617)1.68365049
93Hypoplastic toenails (HP:0001800)1.68269013
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.67483892
95Abnormality of the gastric mucosa (HP:0004295)1.66932826
96Subacute progressive viral hepatitis (HP:0006572)1.66835082
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65939644
98Bowel diverticulosis (HP:0005222)1.65594175
99Long palpebral fissure (HP:0000637)1.65187891
100Sparse eyelashes (HP:0000653)1.63071845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.18259110
2EPHA24.31013338
3LATS22.92241619
4MET2.87164159
5CDK122.84588536
6PDGFRA2.64896680
7MST42.61631170
8NTRK12.42804116
9SCYL22.31872467
10IRAK32.15603168
11SIK11.95833814
12TRIB31.84671363
13PTK21.82873540
14PAK41.72717709
15ERBB41.71763460
16STK101.67962609
17LATS11.66701274
18TESK11.63944801
19NEK91.60618252
20ICK1.56406374
21RIPK11.55096568
22NME21.50980372
23MAP3K91.50820927
24ERN11.50665067
25TESK21.48436185
26ARAF1.42553304
27EPHB21.38914672
28LMTK21.35945164
29MOS1.35864794
30MAP3K141.31956752
31SMG11.26986709
32EIF2AK31.22297360
33TTN1.22251622
34MAP3K121.19390697
35LIMK11.16415010
36PRPF4B1.14196169
37STK241.12769626
38NEK11.10862384
39TTK1.10230306
40BUB11.01448964
41EEF2K1.00186310
42PDGFRB0.99890561
43PBK0.97708635
44EIF2AK10.96680139
45PAK20.95920697
46MAP3K80.91618128
47PIM20.87830296
48MTOR0.87577318
49NEK20.87432157
50CDK80.86215315
51BRD40.83518215
52STK30.81713105
53SRPK10.79759949
54ROCK20.77762637
55TSSK60.77353839
56BMX0.74131928
57DDR20.72023443
58MYLK0.70981705
59TAOK20.70738778
60MAP3K30.70465254
61MAP3K130.69234273
62PKN20.67657565
63STK38L0.67364385
64KDR0.66430189
65FLT30.66276835
66CDK90.62181595
67TGFBR20.60268483
68CDK70.58802378
69KSR10.55207115
70TRPM70.53953936
71MAPKAPK30.53288423
72BMPR20.52864099
73BRAF0.51928035
74KSR20.51355464
75RPS6KB20.49979248
76ILK0.48819110
77AKT20.48448913
78RPS6KA40.44807628
79AURKA0.44541007
80CHEK10.44369918
81PRKCI0.43497127
82ABL20.43052903
83EPHB10.41760472
84LRRK20.40524654
85ALK0.39323324
86CDK60.39232706
87AURKB0.35914578
88FGFR10.34868985
89BCR0.33815404
90CHEK20.33259993
91DMPK0.33063992
92WNK10.32807300
93MAP3K100.31988164
94EIF2AK20.31477570
95MAPKAPK20.31282856
96RAF10.30409948
97MAP3K20.30172676
98CDC42BPA0.29579274
99MELK0.28579349
100TBK10.27591725

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.80360859
2ECM-receptor interaction_Homo sapiens_hsa045122.62398650
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.56217900
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.46898184
5Adherens junction_Homo sapiens_hsa045202.21811530
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06171989
7Focal adhesion_Homo sapiens_hsa045102.05835581
8Small cell lung cancer_Homo sapiens_hsa052222.01631184
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00463205
10Thyroid cancer_Homo sapiens_hsa052161.93498766
11Bladder cancer_Homo sapiens_hsa052191.87231252
12Chronic myeloid leukemia_Homo sapiens_hsa052201.83421122
13Proteoglycans in cancer_Homo sapiens_hsa052051.76856987
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.74430097
15Shigellosis_Homo sapiens_hsa051311.73741927
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66302990
17Pancreatic cancer_Homo sapiens_hsa052121.59956599
18Prion diseases_Homo sapiens_hsa050201.56089945
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51321633
20MicroRNAs in cancer_Homo sapiens_hsa052061.50662327
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43900937
22N-Glycan biosynthesis_Homo sapiens_hsa005101.43726625
23Pentose phosphate pathway_Homo sapiens_hsa000301.41920056
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37876192
25Salmonella infection_Homo sapiens_hsa051321.37225574
26Apoptosis_Homo sapiens_hsa042101.26840892
27Amoebiasis_Homo sapiens_hsa051461.26072292
28Renal cell carcinoma_Homo sapiens_hsa052111.25327542
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21874346
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20277009
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20162344
32Galactose metabolism_Homo sapiens_hsa000521.18572009
33Hippo signaling pathway_Homo sapiens_hsa043901.14099118
34p53 signaling pathway_Homo sapiens_hsa041151.13247423
35Vibrio cholerae infection_Homo sapiens_hsa051101.13068855
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11582318
37Cell cycle_Homo sapiens_hsa041101.06689678
38Nucleotide excision repair_Homo sapiens_hsa034201.02486330
39TGF-beta signaling pathway_Homo sapiens_hsa043500.97971611
40Biosynthesis of amino acids_Homo sapiens_hsa012300.97280701
41PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97057336
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.95712239
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.94127208
44Dilated cardiomyopathy_Homo sapiens_hsa054140.92488072
45Non-small cell lung cancer_Homo sapiens_hsa052230.91416039
46ErbB signaling pathway_Homo sapiens_hsa040120.91076384
47Other glycan degradation_Homo sapiens_hsa005110.90803835
48Endocytosis_Homo sapiens_hsa041440.90713274
49Viral carcinogenesis_Homo sapiens_hsa052030.90552840
50Tight junction_Homo sapiens_hsa045300.90420512
51Endometrial cancer_Homo sapiens_hsa052130.90160689
52Prostate cancer_Homo sapiens_hsa052150.89850105
53Spliceosome_Homo sapiens_hsa030400.87765741
54TNF signaling pathway_Homo sapiens_hsa046680.87434885
55RNA transport_Homo sapiens_hsa030130.87153084
56mRNA surveillance pathway_Homo sapiens_hsa030150.87010057
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85878070
58Pathways in cancer_Homo sapiens_hsa052000.83886578
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78191726
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77896258
61Carbon metabolism_Homo sapiens_hsa012000.73721269
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73646749
63Glioma_Homo sapiens_hsa052140.71460098
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.71350861
65Fructose and mannose metabolism_Homo sapiens_hsa000510.71241413
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69315220
67Insulin signaling pathway_Homo sapiens_hsa049100.68727167
68Melanoma_Homo sapiens_hsa052180.68045167
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68037664
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68032403
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67711172
72Protein digestion and absorption_Homo sapiens_hsa049740.67180848
73Measles_Homo sapiens_hsa051620.66460291
74Acute myeloid leukemia_Homo sapiens_hsa052210.66355489
75HTLV-I infection_Homo sapiens_hsa051660.65543919
76Hepatitis B_Homo sapiens_hsa051610.65098096
77Lysosome_Homo sapiens_hsa041420.63452682
78VEGF signaling pathway_Homo sapiens_hsa043700.63270080
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.61692385
80Hepatitis C_Homo sapiens_hsa051600.59646674
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58607584
82Colorectal cancer_Homo sapiens_hsa052100.58545377
83Toxoplasmosis_Homo sapiens_hsa051450.57578252
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56117134
85DNA replication_Homo sapiens_hsa030300.53494396
86Sphingolipid metabolism_Homo sapiens_hsa006000.51998166
87Sulfur metabolism_Homo sapiens_hsa009200.50749948
88mTOR signaling pathway_Homo sapiens_hsa041500.50270388
89AMPK signaling pathway_Homo sapiens_hsa041520.48678672
90Proteasome_Homo sapiens_hsa030500.48614400
91Influenza A_Homo sapiens_hsa051640.47458473
92Notch signaling pathway_Homo sapiens_hsa043300.47430731
93Axon guidance_Homo sapiens_hsa043600.44761348
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43411513
95Rap1 signaling pathway_Homo sapiens_hsa040150.43047815
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43035774
97Epstein-Barr virus infection_Homo sapiens_hsa051690.42314154
98Viral myocarditis_Homo sapiens_hsa054160.42004612
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.41153412
100Herpes simplex infection_Homo sapiens_hsa051680.40088964

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