ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	6.93682756
2	positive regulation of respiratory burst (GO:0060267)	6.45796682
3	ethanol oxidation (GO:0006069)	5.80022710
4	regulation of guanylate cyclase activity (GO:0031282)	5.75001629
5	ethanol metabolic process (GO:0006067)	5.54988715
6	oligosaccharide biosynthetic process (GO:0009312)	5.51459014
7	intestinal absorption (GO:0050892)	5.36533196
8	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.17928485
9	primary alcohol catabolic process (GO:0034310)	5.16804265
10	angiotensin maturation (GO:0002003)	5.14301952
11	vitamin transmembrane transport (GO:0035461)	5.13186398
12	glomerular filtration (GO:0003094)	4.99781783
13	cilium or flagellum-dependent cell motility (GO:0001539)	4.94152829
14	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.82874337
15	O-glycan processing (GO:0016266)	4.82735847
16	antibacterial humoral response (GO:0019731)	4.65749362
17	regulation of respiratory burst (GO:0060263)	4.65187994
18	positive regulation of pseudopodium assembly (GO:0031274)	4.61253767
19	renal filtration (GO:0097205)	4.57156405
20	motile cilium assembly (GO:0044458)	4.53661045
21	antimicrobial humoral response (GO:0019730)	4.52730036
22	sperm capacitation (GO:0048240)	4.50418983
23	maintenance of gastrointestinal epithelium (GO:0030277)	4.46434597
24	sulfate transmembrane transport (GO:1902358)	4.26063234
25	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.23763996
26	positive regulation of guanylate cyclase activity (GO:0031284)	4.19450438
27	transcytosis (GO:0045056)	4.16900417
28	regulation of cellular extravasation (GO:0002691)	4.15817950
29	regulation of pseudopodium assembly (GO:0031272)	4.13890360
30	cilium movement (GO:0003341)	4.13363696
31	epoxygenase P450 pathway (GO:0019373)	4.09647765
32	cellular glucuronidation (GO:0052695)	4.08421149
33	NADH metabolic process (GO:0006734)	4.03468841
34	glucuronate metabolic process (GO:0019585)	4.02261051
35	uronic acid metabolic process (GO:0006063)	4.02261051
36	endocrine process (GO:0050886)	3.95693743
37	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.95693743
38	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.95693743
39	diterpenoid biosynthetic process (GO:0016102)	3.91150371
40	renal system process involved in regulation of blood volume (GO:0001977)	3.86336502
41	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.83905449
42	regulation of vitamin metabolic process (GO:0030656)	3.80365996
43	desmosome organization (GO:0002934)	3.77953635
44	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.76151404
45	flavonoid metabolic process (GO:0009812)	3.69205697
46	bile acid and bile salt transport (GO:0015721)	3.59251411
47	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.55977807
48	multicellular organismal water homeostasis (GO:0050891)	3.47412152
49	sodium ion homeostasis (GO:0055078)	3.46901702
50	epithelial cilium movement (GO:0003351)	3.46482669
51	excretion (GO:0007588)	3.46458560
52	regulation of systemic arterial blood pressure (GO:0003073)	3.46253649
53	regulation of cGMP biosynthetic process (GO:0030826)	3.43029775
54	nucleoside diphosphate biosynthetic process (GO:0009133)	3.38915708
55	sulfate transport (GO:0008272)	3.38823812
56	primary alcohol metabolic process (GO:0034308)	3.37065672
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.35580353
58	GDP-mannose metabolic process (GO:0019673)	3.34545342
59	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.29841592
60	eosinophil chemotaxis (GO:0048245)	3.24739446
61	exogenous drug catabolic process (GO:0042738)	3.24201493
62	complement activation, classical pathway (GO:0006958)	3.22084610
63	drug metabolic process (GO:0017144)	3.21723365
64	fat-soluble vitamin biosynthetic process (GO:0042362)	3.21429043
65	epithelial structure maintenance (GO:0010669)	3.21391892
66	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.20664179
67	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.20275312
68	digestive system process (GO:0022600)	3.18775033
69	glutathione biosynthetic process (GO:0006750)	3.14540093
70	urea cycle (GO:0000050)	3.09112375
71	intestinal epithelial cell development (GO:0060576)	3.08323012
72	sulfur compound transport (GO:0072348)	3.00765793
73	protein O-linked glycosylation (GO:0006493)	3.00428868
74	negative regulation of myotube differentiation (GO:0010832)	2.98771245
75	nonribosomal peptide biosynthetic process (GO:0019184)	2.98082794
76	sphingomyelin metabolic process (GO:0006684)	2.97849760
77	drug catabolic process (GO:0042737)	2.97791206
78	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.96367205
79	antigen processing and presentation of endogenous antigen (GO:0019883)	2.96262410
80	lipoprotein transport (GO:0042953)	2.93898089
81	glucocorticoid biosynthetic process (GO:0006704)	2.93130428
82	digestion (GO:0007586)	2.90581636
83	eosinophil migration (GO:0072677)	2.88139206
84	urea metabolic process (GO:0019627)	2.87275690
85	glycosylceramide metabolic process (GO:0006677)	2.86883900
86	fucosylation (GO:0036065)	2.86420140
87	retinol metabolic process (GO:0042572)	2.86045572
88	water homeostasis (GO:0030104)	2.85282856
89	hormone catabolic process (GO:0042447)	2.85219879
90	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.84778625
91	bicarbonate transport (GO:0015701)	2.83454684
92	actin filament depolymerization (GO:0030042)	2.83097725
93	glycosphingolipid catabolic process (GO:0046479)	2.80347192
94	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.79893180
95	diacylglycerol metabolic process (GO:0046339)	2.79746504
96	one-carbon compound transport (GO:0019755)	2.79551625
97	regulation of cholesterol homeostasis (GO:2000188)	2.79244555
98	positive regulation of glycoprotein metabolic process (GO:1903020)	2.78481038
99	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.75953652
100	regulation of cGMP metabolic process (GO:0030823)	2.75447439

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CDX2_20551321_ChIP-Seq_CACO-2_Human	4.82461132
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.19418582
3	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.15991233
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.08026640
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.81654028
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.77929948
7	* SOX2_20726797_ChIP-Seq_SW620_Human	2.50209582
8	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.47867958
9	GATA4_25053715_ChIP-Seq_YYC3_Human	2.45252538
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.31838132
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.30764850
12	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.29376758
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.27804899
14	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.24343638
15	GATA6_25053715_ChIP-Seq_YYC3_Human	2.20830718
16	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.11827802
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.11795235
18	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.04555970
19	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.96427519
20	* FOXO3_23340844_ChIP-Seq_DLD1_Human	1.92294578
21	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.87739511
22	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.83036774
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.81156172
24	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.76691097
25	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.76450041
26	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.76355553
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.73424352
28	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.71545417
29	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.69795810
30	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.67861600
31	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.65883921
32	KLF5_25053715_ChIP-Seq_YYC3_Human	1.64033195
33	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.63418934
34	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.62835963
35	* DROSHA_22980978_ChIP-Seq_HELA_Human	1.62159423
36	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.61122436
37	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.60030017
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.59192366
39	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.58214921
40	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.55356461
41	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.49248808
42	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.49115296
43	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.46670969
44	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.46546125
45	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.43071053
46	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.39787517
47	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.37758706
48	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.33331132
49	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.32866536
50	CLOCK_20551151_ChIP-Seq_293T_Human	1.29865732
51	STAT1_20625510_ChIP-Seq_HELA_Human	1.28804780
52	ZNF263_19887448_ChIP-Seq_K562_Human	1.27306787
53	GATA1_19941826_ChIP-Seq_K562_Human	1.20589616
54	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.20247560
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19833658
56	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.18223308
57	TP63_22573176_ChIP-Seq_HFKS_Human	1.17527690
58	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.16138089
59	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.12265781
60	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11929907
61	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.10748109
62	SA1_27219007_Chip-Seq_Bcells_Human	1.09896394
63	CREB1_26743006_Chip-Seq_LNCaP_Human	1.09750370
64	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.08250268
65	CTCF_27219007_Chip-Seq_Bcells_Human	1.08077565
66	BCL6_27268052_Chip-Seq_Bcells_Human	1.07934433
67	GATA2_19941826_ChIP-Seq_K562_Human	1.05118110
68	BCOR_27268052_Chip-Seq_Bcells_Human	1.03895444
69	* CEBPB_22108803_ChIP-Seq_LS180_Human	1.03211762
70	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01596842
71	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.01504221
72	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.99667501
73	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.99578847
74	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99148623
75	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.95417471
76	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.94441414
77	* SMC4_20622854_ChIP-Seq_HELA_Human	0.93690847
78	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.91181001
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.88765201
80	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.87556580
81	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.87527672
82	* CDX2_22108803_ChIP-Seq_LS180_Human	0.87474761
83	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.87433302
84	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.86846700
85	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.86754182
86	CTCF_20526341_ChIP-Seq_ESCs_Human	0.86628169
87	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.85117004
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.85095215
89	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.84875089
90	PHF8_20622854_ChIP-Seq_HELA_Human	0.84156911
91	VDR_24763502_ChIP-Seq_THP-1_Human	0.82446954
92	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.81992286
93	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.81149246
94	* E2F1_20622854_ChIP-Seq_HELA_Human	0.81092865
95	P300_27268052_Chip-Seq_Bcells_Human	0.80724365
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79892981
97	TP63_23658742_ChIP-Seq_EP156T_Human	0.79357599
98	P68_20966046_ChIP-Seq_HELA_Human	0.79269005
99	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.78257206
100	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.76761324

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.63488752
2	MP0002139_abnormal_hepatobiliary_system	4.88615765
3	MP0005360_urolithiasis	3.80028538
4	MP0004043_abnormal_pH_regulation	3.77107297
5	MP0009379_abnormal_foot_pigmentation	3.40462589
6	MP0010155_abnormal_intestine_physiology	3.36291960
7	MP0005085_abnormal_gallbladder_physiolo	3.26371565
8	MP0004264_abnormal_extraembryonic_tissu	3.10569335
9	MP0003866_abnormal_defecation	3.03717268
10	MP0001666_abnormal_nutrient_absorption	2.91847389
11	MP0010352_gastrointestinal_tract_polyps	2.74618697
12	MP0005365_abnormal_bile_salt	2.60634231
13	MP0001664_abnormal_digestion	2.59973644
14	MP0004019_abnormal_vitamin_homeostasis	2.39430670
15	MP0008875_abnormal_xenobiotic_pharmacok	2.30099523
16	MP0001765_abnormal_ion_homeostasis	2.29022788
17	MP0000490_abnormal_crypts_of	2.28113421
18	MP0001663_abnormal_digestive_system	2.24047092
19	MP0003183_abnormal_peptide_metabolism	2.21709100
20	MP0000477_abnormal_intestine_morphology	2.11966201
21	MP0001873_stomach_inflammation	1.96020385
22	MP0004147_increased_porphyrin_level	1.93369481
23	MP0005381_digestive/alimentary_phenotyp	1.90089306
24	MP0002796_impaired_skin_barrier	1.85895839
25	MP0000678_abnormal_parathyroid_gland	1.83778469
26	MP0000465_gastrointestinal_hemorrhage	1.83401461
27	MP0005409_darkened_coat_color	1.82450712
28	MP0005166_decreased_susceptibility_to	1.79563712
29	MP0005636_abnormal_mineral_homeostasis	1.67921875
30	MP0004782_abnormal_surfactant_physiolog	1.67142367
31	MP0003303_peritoneal_inflammation	1.64592930
32	MP0003868_abnormal_feces_composition	1.61348669
33	MP0002876_abnormal_thyroid_physiology	1.56841355
34	MP0009643_abnormal_urine_homeostasis	1.53785690
35	MP0004858_abnormal_nervous_system	1.48540885
36	MP0000566_synostosis	1.46734253
37	MP0002098_abnormal_vibrissa_morphology	1.44717825
38	MP0003724_increased_susceptibility_to	1.44449724
39	MP0009840_abnormal_foam_cell	1.36982091
40	MP0002138_abnormal_hepatobiliary_system	1.25371306
41	MP0002136_abnormal_kidney_physiology	1.25332060
42	MP0002132_abnormal_respiratory_system	1.25321008
43	MP0005165_increased_susceptibility_to	1.22635581
44	MP0010678_abnormal_skin_adnexa	1.22017152
45	MP0002277_abnormal_respiratory_mucosa	1.16140830
46	MP0005310_abnormal_salivary_gland	1.11259885
47	MP0000462_abnormal_digestive_system	1.09731268
48	MP0009780_abnormal_chondrocyte_physiolo	1.09545667
49	MP0003252_abnormal_bile_duct	1.07980195
50	MP0008004_abnormal_stomach_pH	1.06330715
51	MP0001756_abnormal_urination	1.02173235
52	MP0001188_hyperpigmentation	1.00916240
53	MP0005025_abnormal_response_to	1.00673353
54	MP0005387_immune_system_phenotype	1.00406782
55	MP0001790_abnormal_immune_system	1.00406782
56	MP0009785_altered_susceptibility_to	0.99684317
57	MP0005501_abnormal_skin_physiology	0.99311742
58	MP0003191_abnormal_cellular_cholesterol	0.96996308
59	MP0006082_CNS_inflammation	0.96732986
60	MP0001845_abnormal_inflammatory_respons	0.95605728
61	MP0000467_abnormal_esophagus_morphology	0.94393242
62	MP0002166_altered_tumor_susceptibility	0.93438994
63	MP0003806_abnormal_nucleotide_metabolis	0.93338271
64	MP0010329_abnormal_lipoprotein_level	0.91030223
65	MP0005451_abnormal_body_composition	0.90200699
66	MP0005670_abnormal_white_adipose	0.89446626
67	MP0004947_skin_inflammation	0.87947389
68	MP0003453_abnormal_keratinocyte_physiol	0.87848563
69	MP0001849_ear_inflammation	0.87747619
70	MP0002896_abnormal_bone_mineralization	0.87196670
71	MP0000537_abnormal_urethra_morphology	0.86789346
72	MP0003879_abnormal_hair_cell	0.86469116
73	MP0005332_abnormal_amino_acid	0.85238986
74	MP0005319_abnormal_enzyme/_coenzyme	0.83049994
75	MP0001764_abnormal_homeostasis	0.82635205
76	MP0003436_decreased_susceptibility_to	0.79343939
77	MP0003300_gastrointestinal_ulcer	0.78681858
78	MP0003329_amyloid_beta_deposits	0.77911269
79	MP0002822_catalepsy	0.77455787
80	MP0002009_preneoplasia	0.75982521
81	MP0000681_abnormal_thyroid_gland	0.75849422
82	MP0002118_abnormal_lipid_homeostasis	0.75377656
83	MP0000230_abnormal_systemic_arterial	0.74636702
84	MP0001485_abnormal_pinna_reflex	0.74049970
85	MP0001533_abnormal_skeleton_physiology	0.72387604
86	MP0003075_altered_response_to	0.70810790
87	MP0001216_abnormal_epidermal_layer	0.69677677
88	MP0000609_abnormal_liver_physiology	0.68122943
89	MP0008872_abnormal_physiological_respon	0.67085879
90	MP0001835_abnormal_antigen_presentation	0.66960079
91	MP0002148_abnormal_hypersensitivity_rea	0.65455983
92	MP0005083_abnormal_biliary_tract	0.64347190
93	MP0005058_abnormal_lysosome_morphology	0.64193190
94	MP0000858_altered_metastatic_potential	0.63240100
95	MP0000249_abnormal_blood_vessel	0.63161134
96	MP0005584_abnormal_enzyme/coenzyme_acti	0.62958574
97	MP0002006_tumorigenesis	0.62949507
98	MP0005023_abnormal_wound_healing	0.62593457
99	MP0002653_abnormal_ependyma_morphology	0.61193615
100	MP0000470_abnormal_stomach_morphology	0.61034993

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperactive renin-angiotensin system (HP:0000841)	8.57389720
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.00251927
3	Decreased circulating renin level (HP:0003351)	6.28836348
4	Chronic bronchitis (HP:0004469)	6.12723261
5	Abnormal respiratory epithelium morphology (HP:0012253)	5.89842360
6	Abnormal respiratory motile cilium morphology (HP:0005938)	5.89842360
7	Abnormal respiratory motile cilium physiology (HP:0012261)	5.88443724
8	Rhinitis (HP:0012384)	5.73375316
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.54631474
10	Absent/shortened dynein arms (HP:0200106)	5.54631474
11	Abnormal ciliary motility (HP:0012262)	5.53724534
12	Abnormality of renin-angiotensin system (HP:0000847)	5.53200438
13	Nasal polyposis (HP:0100582)	4.95348310
14	Abnormality of the nasal mucosa (HP:0000433)	4.94753039
15	Bronchiectasis (HP:0002110)	4.84552694
16	Metabolic alkalosis (HP:0200114)	4.76484376
17	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.70742815
18	Flat acetabular roof (HP:0003180)	4.43540674
19	Abnormality of chloride homeostasis (HP:0011422)	4.41933112
20	Malnutrition (HP:0004395)	4.34903620
21	Hyperaldosteronism (HP:0000859)	4.24382020
22	Alkalosis (HP:0001948)	4.16246694
23	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.75812313
24	Bronchitis (HP:0012387)	3.50695092
25	Hyponatremia (HP:0002902)	3.37561347
26	Ileus (HP:0002595)	3.11739183
27	Hyperkalemia (HP:0002153)	3.08992795
28	Systemic lupus erythematosus (HP:0002725)	2.97419094
29	Right ventricular cardiomyopathy (HP:0011663)	2.95718658
30	Recurrent sinusitis (HP:0011108)	2.94186756
31	Hydroxyprolinuria (HP:0003080)	2.86545572
32	Abnormality of proline metabolism (HP:0010907)	2.86545572
33	Abdominal distention (HP:0003270)	2.85299106
34	Hemorrhage of the eye (HP:0011885)	2.82129878
35	Fat malabsorption (HP:0002630)	2.75972561
36	Chronic sinusitis (HP:0011109)	2.74309285
37	Hypokalemia (HP:0002900)	2.72000185
38	Chronic diarrhea (HP:0002028)	2.71289906
39	Chronic otitis media (HP:0000389)	2.56999248
40	Abnormality of sodium homeostasis (HP:0010931)	2.55623558
41	Abnormality of potassium homeostasis (HP:0011042)	2.53547704
42	Renal salt wasting (HP:0000127)	2.50929487
43	Pili torti (HP:0003777)	2.48118625
44	Flattened epiphyses (HP:0003071)	2.44298912
45	Recurrent otitis media (HP:0000403)	2.41970098
46	Abnormality of small intestinal villus morphology (HP:0011472)	2.38099648
47	Villous atrophy (HP:0011473)	2.38099648
48	Hypotension (HP:0002615)	2.34670612
49	Intrahepatic cholestasis (HP:0001406)	2.34286884
50	Infertility (HP:0000789)	2.34144844
51	Adrenal overactivity (HP:0002717)	2.33817416
52	Male infertility (HP:0003251)	2.33458787
53	Congenital sensorineural hearing impairment (HP:0008527)	2.32050797
54	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.28956843
55	Spinal cord compression (HP:0002176)	2.19929900
56	Conjugated hyperbilirubinemia (HP:0002908)	2.19400083
57	Eczematoid dermatitis (HP:0000976)	2.18561604
58	Abnormal tarsal ossification (HP:0008369)	2.13737239
59	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.12822400
60	Abnormality of vitamin metabolism (HP:0100508)	2.12745180
61	Dehydration (HP:0001944)	2.12318660
62	Abnormality of vitamin B metabolism (HP:0004340)	2.09891203
63	Abnormality of carpal bone ossification (HP:0006257)	2.06675079
64	Hyperparathyroidism (HP:0000843)	2.06207913
65	Neonatal short-limb short stature (HP:0008921)	2.06079322
66	Ventricular fibrillation (HP:0001663)	2.05054955
67	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.99854892
68	Abnormal hair laboratory examination (HP:0003328)	1.99485010
69	Widely patent fontanelles and sutures (HP:0004492)	1.95076236
70	Glomerulonephritis (HP:0000099)	1.89821233
71	Syncope (HP:0001279)	1.88713233
72	Visceral angiomatosis (HP:0100761)	1.88684666
73	Abnormality of the distal phalanges of the toes (HP:0010182)	1.85254511
74	Abnormal vertebral ossification (HP:0100569)	1.85003487
75	Abnormality of complement system (HP:0005339)	1.80740530
76	Hyperphosphatemia (HP:0002905)	1.79753312
77	Thin bony cortex (HP:0002753)	1.79438749
78	Complement deficiency (HP:0004431)	1.78232718
79	Growth hormone excess (HP:0000845)	1.74080453
80	Nephritis (HP:0000123)	1.73778907
81	Atelectasis (HP:0100750)	1.72705929
82	Recurrent bronchitis (HP:0002837)	1.70550725
83	Abnormal biliary tract morphology (HP:0012440)	1.66581102
84	Hyperammonemia (HP:0001987)	1.64142372
85	Hemangiomatosis (HP:0007461)	1.62341603
86	Aplasia/hypoplasia of the femur (HP:0005613)	1.61783269
87	Focal segmental glomerulosclerosis (HP:0000097)	1.56647512
88	Flat capital femoral epiphysis (HP:0003370)	1.56570542
89	Renal tubular acidosis (HP:0001947)	1.55582601
90	Abnormal hand bone ossification (HP:0010660)	1.55362472
91	Severe short stature (HP:0003510)	1.53607552
92	Abnormal ossification of hand bones (HP:0005921)	1.52293181
93	Vascular calcification (HP:0004934)	1.51879173
94	Mildly elevated creatine phosphokinase (HP:0008180)	1.51497757
95	Abnormality of the 1st metacarpal (HP:0010009)	1.51313165
96	Steatorrhea (HP:0002570)	1.49441163
97	Dicarboxylic aciduria (HP:0003215)	1.48792594
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.48792594
99	Protuberant abdomen (HP:0001538)	1.46767211
100	Premature loss of primary teeth (HP:0006323)	1.43907795

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	6.42629336
2	MST1R	5.34004512
3	ACVR1B	4.67801365
4	MAPK15	4.03795024
5	RIPK1	3.99011089
6	ERN1	3.24922075
7	PIK3CA	3.13762623
8	LMTK2	3.13098894
9	MST4	2.48691343
10	EPHB2	2.08954752
11	STK24	2.05378150
12	MET	1.96183681
13	PRKG2	1.91592094
14	STK39	1.84814945
15	MAP3K2	1.74462167
16	PTK6	1.69388411
17	SMG1	1.61045489
18	MAP3K10	1.57659656
19	TESK1	1.53054182
20	EPHB1	1.46677247
21	MAP3K12	1.44818831
22	EPHA3	1.35838526
23	OXSR1	1.29886871
24	RIPK4	1.28111029
25	FGFR4	1.27324595
26	MAPKAPK3	1.23337627
27	MYLK	1.19894149
28	TYK2	1.08993930
29	CSK	1.05414566
30	TAOK1	1.04826381
31	GRK6	1.04467166
32	MAP3K3	1.03308383
33	MAP2K2	1.03285492
34	TRIB3	0.99585998
35	DDR2	0.95651982
36	TESK2	0.95383187
37	NME1	0.94535888
38	MATK	0.90865578
39	CDC42BPA	0.87901662
40	ERBB2	0.87805954
41	PDPK1	0.85302597
42	MAP3K1	0.84456273
43	TBK1	0.83915224
44	FGFR3	0.82006746
45	FER	0.74035378
46	PAK4	0.72255443
47	ZAP70	0.69609720
48	PRPF4B	0.68649047
49	PRKAA2	0.64861287
50	ABL2	0.64348758
51	MAP2K6	0.63584123
52	WNK4	0.62555575
53	LRRK2	0.61800351
54	MAP3K11	0.60769838
55	EEF2K	0.57335348
56	PRKCI	0.56715461
57	NLK	0.56258452
58	PDK2	0.56117262
59	MAP4K1	0.50448621
60	PTK2	0.47557364
61	DMPK	0.47261910
62	MAPK11	0.44546826
63	PDK1	0.44515682
64	IRAK1	0.44224286
65	NEK6	0.43570939
66	SRC	0.42395634
67	DYRK1B	0.41415214
68	PRKCA	0.39243537
69	PRKCD	0.38223917
70	CAMK2D	0.37442580
71	RET	0.36131637
72	ICK	0.34073680
73	FYN	0.32636925
74	BMPR2	0.32425074
75	PRKACG	0.32232107
76	KSR2	0.31274861
77	RPS6KA2	0.30736276
78	CDK19	0.30243365
79	CAMK2G	0.30048134
80	IKBKE	0.29121840
81	EPHA4	0.26737430
82	MAPKAPK2	0.26714244
83	PRKCQ	0.25886495
84	BMX	0.22317072
85	JAK2	0.21957162
86	PIM2	0.21550182
87	TTK	0.21299022
88	LYN	0.20156246
89	MAP2K1	0.20044434
90	BCR	0.19084395
91	PRKCZ	0.19014124
92	YES1	0.18734721
93	CDK6	0.18640784
94	JAK1	0.18315899
95	GRK1	0.18097472
96	IGF1R	0.17481720
97	BLK	0.16477360
98	MAP3K14	0.15751121
99	MAP3K7	0.14865235
100	PKN2	0.14757373

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.28863907
2	Sulfur metabolism_Homo sapiens_hsa00920	3.46521600
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.06147282
4	Histidine metabolism_Homo sapiens_hsa00340	2.95800563
5	Fat digestion and absorption_Homo sapiens_hsa04975	2.80405126
6	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.68658643
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.60650216
8	Caffeine metabolism_Homo sapiens_hsa00232	2.56121282
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.50874338
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.43757397
11	Mineral absorption_Homo sapiens_hsa04978	2.37892839
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.33736863
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.10579870
14	Retinol metabolism_Homo sapiens_hsa00830	2.08939196
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.06429837
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.03859757
17	Renin-angiotensin system_Homo sapiens_hsa04614	1.95397398
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.91805989
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.86964282
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.82632264
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.77726659
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.73428788
23	Fatty acid degradation_Homo sapiens_hsa00071	1.70334974
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.59789656
25	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.58015321
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54218418
27	Tyrosine metabolism_Homo sapiens_hsa00350	1.45315711
28	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.43499197
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.42326306
30	Glutathione metabolism_Homo sapiens_hsa00480	1.35860268
31	Bile secretion_Homo sapiens_hsa04976	1.33741882
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31224785
33	Protein digestion and absorption_Homo sapiens_hsa04974	1.27435369
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.23132013
35	Pancreatic secretion_Homo sapiens_hsa04972	1.22636377
36	Asthma_Homo sapiens_hsa05310	1.19281758
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16139842
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12596465
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12588917
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09198407
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.08025008
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06494210
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.03704946
44	Galactose metabolism_Homo sapiens_hsa00052	1.03118329
45	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.99462718
46	Allograft rejection_Homo sapiens_hsa05330	0.92191396
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91060466
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90978168
49	Other glycan degradation_Homo sapiens_hsa00511	0.89100458
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88231820
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.85869686
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.84764564
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.82992394
54	Graft-versus-host disease_Homo sapiens_hsa05332	0.80974631
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80756417
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.79394549
57	Tight junction_Homo sapiens_hsa04530	0.79335296
58	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.76881007
59	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68337129
60	Hepatitis C_Homo sapiens_hsa05160	0.66234953
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65341183
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61570010
63	Peroxisome_Homo sapiens_hsa04146	0.59937832
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.57908476
65	Sulfur relay system_Homo sapiens_hsa04122	0.54783686
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.52299320
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47329162
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47149720
69	Antigen processing and presentation_Homo sapiens_hsa04612	0.44529775
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41002842
71	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40227131
72	Pertussis_Homo sapiens_hsa05133	0.39614849
73	Renin secretion_Homo sapiens_hsa04924	0.38852459
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.36766554
75	Leishmaniasis_Homo sapiens_hsa05140	0.36364432
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.32223916
77	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.31984456
78	Insulin resistance_Homo sapiens_hsa04931	0.24685878
79	Amoebiasis_Homo sapiens_hsa05146	0.23030701
80	Butanoate metabolism_Homo sapiens_hsa00650	0.21754948
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.21197558
82	Viral myocarditis_Homo sapiens_hsa05416	0.20982766
83	Salmonella infection_Homo sapiens_hsa05132	0.20620497
84	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.20519751
85	Metabolic pathways_Homo sapiens_hsa01100	0.17744386
86	Salivary secretion_Homo sapiens_hsa04970	0.16164527
87	Influenza A_Homo sapiens_hsa05164	0.15767224
88	Toxoplasmosis_Homo sapiens_hsa05145	0.15581114
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.14755626
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.14697688
91	ABC transporters_Homo sapiens_hsa02010	0.14171369
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.14137401
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.13408986
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.12806757
95	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.12006343
96	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.11734656
97	Tuberculosis_Homo sapiens_hsa05152	0.10882496
98	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.09701074
99	Choline metabolism in cancer_Homo sapiens_hsa05231	0.07884732
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.06898880

FAM3D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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