FAM3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.93682756
2positive regulation of respiratory burst (GO:0060267)6.45796682
3ethanol oxidation (GO:0006069)5.80022710
4regulation of guanylate cyclase activity (GO:0031282)5.75001629
5ethanol metabolic process (GO:0006067)5.54988715
6oligosaccharide biosynthetic process (GO:0009312)5.51459014
7intestinal absorption (GO:0050892)5.36533196
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.17928485
9primary alcohol catabolic process (GO:0034310)5.16804265
10angiotensin maturation (GO:0002003)5.14301952
11vitamin transmembrane transport (GO:0035461)5.13186398
12glomerular filtration (GO:0003094)4.99781783
13cilium or flagellum-dependent cell motility (GO:0001539)4.94152829
14calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.82874337
15O-glycan processing (GO:0016266)4.82735847
16antibacterial humoral response (GO:0019731)4.65749362
17regulation of respiratory burst (GO:0060263)4.65187994
18positive regulation of pseudopodium assembly (GO:0031274)4.61253767
19renal filtration (GO:0097205)4.57156405
20motile cilium assembly (GO:0044458)4.53661045
21antimicrobial humoral response (GO:0019730)4.52730036
22sperm capacitation (GO:0048240)4.50418983
23maintenance of gastrointestinal epithelium (GO:0030277)4.46434597
24sulfate transmembrane transport (GO:1902358)4.26063234
25pyrimidine-containing compound transmembrane transport (GO:0072531)4.23763996
26positive regulation of guanylate cyclase activity (GO:0031284)4.19450438
27transcytosis (GO:0045056)4.16900417
28regulation of cellular extravasation (GO:0002691)4.15817950
29regulation of pseudopodium assembly (GO:0031272)4.13890360
30cilium movement (GO:0003341)4.13363696
31epoxygenase P450 pathway (GO:0019373)4.09647765
32cellular glucuronidation (GO:0052695)4.08421149
33NADH metabolic process (GO:0006734)4.03468841
34uronic acid metabolic process (GO:0006063)4.02261051
35glucuronate metabolic process (GO:0019585)4.02261051
36regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.95693743
37endocrine process (GO:0050886)3.95693743
38regulation of systemic arterial blood pressure by hormone (GO:0001990)3.95693743
39diterpenoid biosynthetic process (GO:0016102)3.91150371
40renal system process involved in regulation of blood volume (GO:0001977)3.86336502
41phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.83905449
42regulation of vitamin metabolic process (GO:0030656)3.80365996
43desmosome organization (GO:0002934)3.77953635
44receptor guanylyl cyclase signaling pathway (GO:0007168)3.76151404
45flavonoid metabolic process (GO:0009812)3.69205697
46bile acid and bile salt transport (GO:0015721)3.59251411
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.55977807
48multicellular organismal water homeostasis (GO:0050891)3.47412152
49sodium ion homeostasis (GO:0055078)3.46901702
50epithelial cilium movement (GO:0003351)3.46482669
51excretion (GO:0007588)3.46458560
52regulation of systemic arterial blood pressure (GO:0003073)3.46253649
53regulation of cGMP biosynthetic process (GO:0030826)3.43029775
54nucleoside diphosphate biosynthetic process (GO:0009133)3.38915708
55sulfate transport (GO:0008272)3.38823812
56primary alcohol metabolic process (GO:0034308)3.37065672
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35580353
58GDP-mannose metabolic process (GO:0019673)3.34545342
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29841592
60eosinophil chemotaxis (GO:0048245)3.24739446
61exogenous drug catabolic process (GO:0042738)3.24201493
62complement activation, classical pathway (GO:0006958)3.22084610
63drug metabolic process (GO:0017144)3.21723365
64fat-soluble vitamin biosynthetic process (GO:0042362)3.21429043
65epithelial structure maintenance (GO:0010669)3.21391892
66positive regulation of Cdc42 GTPase activity (GO:0043089)3.20664179
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20275312
68digestive system process (GO:0022600)3.18775033
69glutathione biosynthetic process (GO:0006750)3.14540093
70urea cycle (GO:0000050)3.09112375
71intestinal epithelial cell development (GO:0060576)3.08323012
72sulfur compound transport (GO:0072348)3.00765793
73protein O-linked glycosylation (GO:0006493)3.00428868
74negative regulation of myotube differentiation (GO:0010832)2.98771245
75nonribosomal peptide biosynthetic process (GO:0019184)2.98082794
76sphingomyelin metabolic process (GO:0006684)2.97849760
77drug catabolic process (GO:0042737)2.97791206
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.96367205
79antigen processing and presentation of endogenous antigen (GO:0019883)2.96262410
80lipoprotein transport (GO:0042953)2.93898089
81glucocorticoid biosynthetic process (GO:0006704)2.93130428
82digestion (GO:0007586)2.90581636
83eosinophil migration (GO:0072677)2.88139206
84urea metabolic process (GO:0019627)2.87275690
85glycosylceramide metabolic process (GO:0006677)2.86883900
86fucosylation (GO:0036065)2.86420140
87retinol metabolic process (GO:0042572)2.86045572
88water homeostasis (GO:0030104)2.85282856
89hormone catabolic process (GO:0042447)2.85219879
90regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84778625
91bicarbonate transport (GO:0015701)2.83454684
92actin filament depolymerization (GO:0030042)2.83097725
93glycosphingolipid catabolic process (GO:0046479)2.80347192
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79893180
95diacylglycerol metabolic process (GO:0046339)2.79746504
96one-carbon compound transport (GO:0019755)2.79551625
97regulation of cholesterol homeostasis (GO:2000188)2.79244555
98positive regulation of glycoprotein metabolic process (GO:1903020)2.78481038
99positive regulation of glycoprotein biosynthetic process (GO:0010560)2.75953652
100regulation of cGMP metabolic process (GO:0030823)2.75447439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.82461132
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.19418582
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.15991233
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08026640
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.81654028
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77929948
7* SOX2_20726797_ChIP-Seq_SW620_Human2.50209582
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47867958
9GATA4_25053715_ChIP-Seq_YYC3_Human2.45252538
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.31838132
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.30764850
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.29376758
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27804899
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24343638
15GATA6_25053715_ChIP-Seq_YYC3_Human2.20830718
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11827802
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.11795235
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.04555970
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.96427519
20* FOXO3_23340844_ChIP-Seq_DLD1_Human1.92294578
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87739511
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83036774
23RACK7_27058665_Chip-Seq_MCF-7_Human1.81156172
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76691097
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76450041
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.76355553
27LXR_22292898_ChIP-Seq_THP-1_Human1.73424352
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.71545417
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.69795810
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67861600
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65883921
32KLF5_25053715_ChIP-Seq_YYC3_Human1.64033195
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63418934
34* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62835963
35* DROSHA_22980978_ChIP-Seq_HELA_Human1.62159423
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61122436
37P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60030017
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59192366
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.58214921
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55356461
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49248808
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49115296
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46670969
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46546125
45* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43071053
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39787517
47BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.37758706
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.33331132
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32866536
50CLOCK_20551151_ChIP-Seq_293T_Human1.29865732
51STAT1_20625510_ChIP-Seq_HELA_Human1.28804780
52ZNF263_19887448_ChIP-Seq_K562_Human1.27306787
53GATA1_19941826_ChIP-Seq_K562_Human1.20589616
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.20247560
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19833658
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18223308
57TP63_22573176_ChIP-Seq_HFKS_Human1.17527690
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16138089
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.12265781
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.11929907
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10748109
62SA1_27219007_Chip-Seq_Bcells_Human1.09896394
63CREB1_26743006_Chip-Seq_LNCaP_Human1.09750370
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08250268
65CTCF_27219007_Chip-Seq_Bcells_Human1.08077565
66BCL6_27268052_Chip-Seq_Bcells_Human1.07934433
67GATA2_19941826_ChIP-Seq_K562_Human1.05118110
68BCOR_27268052_Chip-Seq_Bcells_Human1.03895444
69* CEBPB_22108803_ChIP-Seq_LS180_Human1.03211762
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01596842
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01504221
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99667501
73FOXA2_19822575_ChIP-Seq_HepG2_Human0.99578847
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99148623
75ESR1_20079471_ChIP-ChIP_T-47D_Human0.95417471
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94441414
77* SMC4_20622854_ChIP-Seq_HELA_Human0.93690847
78JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91181001
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.88765201
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87556580
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87527672
82* CDX2_22108803_ChIP-Seq_LS180_Human0.87474761
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87433302
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.86846700
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86754182
86CTCF_20526341_ChIP-Seq_ESCs_Human0.86628169
87HNF4A_19822575_ChIP-Seq_HepG2_Human0.85117004
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85095215
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84875089
90PHF8_20622854_ChIP-Seq_HELA_Human0.84156911
91VDR_24763502_ChIP-Seq_THP-1_Human0.82446954
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81992286
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.81149246
94* E2F1_20622854_ChIP-Seq_HELA_Human0.81092865
95P300_27268052_Chip-Seq_Bcells_Human0.80724365
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79892981
97TP63_23658742_ChIP-Seq_EP156T_Human0.79357599
98P68_20966046_ChIP-Seq_HELA_Human0.79269005
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78257206
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76761324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.63488752
2MP0002139_abnormal_hepatobiliary_system4.88615765
3MP0005360_urolithiasis3.80028538
4MP0004043_abnormal_pH_regulation3.77107297
5MP0009379_abnormal_foot_pigmentation3.40462589
6MP0010155_abnormal_intestine_physiology3.36291960
7MP0005085_abnormal_gallbladder_physiolo3.26371565
8MP0004264_abnormal_extraembryonic_tissu3.10569335
9MP0003866_abnormal_defecation3.03717268
10MP0001666_abnormal_nutrient_absorption2.91847389
11MP0010352_gastrointestinal_tract_polyps2.74618697
12MP0005365_abnormal_bile_salt2.60634231
13MP0001664_abnormal_digestion2.59973644
14MP0004019_abnormal_vitamin_homeostasis2.39430670
15MP0008875_abnormal_xenobiotic_pharmacok2.30099523
16MP0001765_abnormal_ion_homeostasis2.29022788
17MP0000490_abnormal_crypts_of2.28113421
18MP0001663_abnormal_digestive_system2.24047092
19MP0003183_abnormal_peptide_metabolism2.21709100
20MP0000477_abnormal_intestine_morphology2.11966201
21MP0001873_stomach_inflammation1.96020385
22MP0004147_increased_porphyrin_level1.93369481
23MP0005381_digestive/alimentary_phenotyp1.90089306
24MP0002796_impaired_skin_barrier1.85895839
25MP0000678_abnormal_parathyroid_gland1.83778469
26MP0000465_gastrointestinal_hemorrhage1.83401461
27MP0005409_darkened_coat_color1.82450712
28MP0005166_decreased_susceptibility_to1.79563712
29MP0005636_abnormal_mineral_homeostasis1.67921875
30MP0004782_abnormal_surfactant_physiolog1.67142367
31MP0003303_peritoneal_inflammation1.64592930
32MP0003868_abnormal_feces_composition1.61348669
33MP0002876_abnormal_thyroid_physiology1.56841355
34MP0009643_abnormal_urine_homeostasis1.53785690
35MP0004858_abnormal_nervous_system1.48540885
36MP0000566_synostosis1.46734253
37MP0002098_abnormal_vibrissa_morphology1.44717825
38MP0003724_increased_susceptibility_to1.44449724
39MP0009840_abnormal_foam_cell1.36982091
40MP0002138_abnormal_hepatobiliary_system1.25371306
41MP0002136_abnormal_kidney_physiology1.25332060
42MP0002132_abnormal_respiratory_system1.25321008
43MP0005165_increased_susceptibility_to1.22635581
44MP0010678_abnormal_skin_adnexa1.22017152
45MP0002277_abnormal_respiratory_mucosa1.16140830
46MP0005310_abnormal_salivary_gland1.11259885
47MP0000462_abnormal_digestive_system1.09731268
48MP0009780_abnormal_chondrocyte_physiolo1.09545667
49MP0003252_abnormal_bile_duct1.07980195
50MP0008004_abnormal_stomach_pH1.06330715
51MP0001756_abnormal_urination1.02173235
52MP0001188_hyperpigmentation1.00916240
53MP0005025_abnormal_response_to1.00673353
54MP0001790_abnormal_immune_system1.00406782
55MP0005387_immune_system_phenotype1.00406782
56MP0009785_altered_susceptibility_to0.99684317
57MP0005501_abnormal_skin_physiology0.99311742
58MP0003191_abnormal_cellular_cholesterol0.96996308
59MP0006082_CNS_inflammation0.96732986
60MP0001845_abnormal_inflammatory_respons0.95605728
61MP0000467_abnormal_esophagus_morphology0.94393242
62MP0002166_altered_tumor_susceptibility0.93438994
63MP0003806_abnormal_nucleotide_metabolis0.93338271
64MP0010329_abnormal_lipoprotein_level0.91030223
65MP0005451_abnormal_body_composition0.90200699
66MP0005670_abnormal_white_adipose0.89446626
67MP0004947_skin_inflammation0.87947389
68MP0003453_abnormal_keratinocyte_physiol0.87848563
69MP0001849_ear_inflammation0.87747619
70MP0002896_abnormal_bone_mineralization0.87196670
71MP0000537_abnormal_urethra_morphology0.86789346
72MP0003879_abnormal_hair_cell0.86469116
73MP0005332_abnormal_amino_acid0.85238986
74MP0005319_abnormal_enzyme/_coenzyme0.83049994
75MP0001764_abnormal_homeostasis0.82635205
76MP0003436_decreased_susceptibility_to0.79343939
77MP0003300_gastrointestinal_ulcer0.78681858
78MP0003329_amyloid_beta_deposits0.77911269
79MP0002822_catalepsy0.77455787
80MP0002009_preneoplasia0.75982521
81MP0000681_abnormal_thyroid_gland0.75849422
82MP0002118_abnormal_lipid_homeostasis0.75377656
83MP0000230_abnormal_systemic_arterial0.74636702
84MP0001485_abnormal_pinna_reflex0.74049970
85MP0001533_abnormal_skeleton_physiology0.72387604
86MP0003075_altered_response_to0.70810790
87MP0001216_abnormal_epidermal_layer0.69677677
88MP0000609_abnormal_liver_physiology0.68122943
89MP0008872_abnormal_physiological_respon0.67085879
90MP0001835_abnormal_antigen_presentation0.66960079
91MP0002148_abnormal_hypersensitivity_rea0.65455983
92MP0005083_abnormal_biliary_tract0.64347190
93MP0005058_abnormal_lysosome_morphology0.64193190
94MP0000858_altered_metastatic_potential0.63240100
95MP0000249_abnormal_blood_vessel0.63161134
96MP0005584_abnormal_enzyme/coenzyme_acti0.62958574
97MP0002006_tumorigenesis0.62949507
98MP0005023_abnormal_wound_healing0.62593457
99MP0002653_abnormal_ependyma_morphology0.61193615
100MP0000470_abnormal_stomach_morphology0.61034993

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.57389720
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.00251927
3Decreased circulating renin level (HP:0003351)6.28836348
4Chronic bronchitis (HP:0004469)6.12723261
5Abnormal respiratory motile cilium morphology (HP:0005938)5.89842360
6Abnormal respiratory epithelium morphology (HP:0012253)5.89842360
7Abnormal respiratory motile cilium physiology (HP:0012261)5.88443724
8Rhinitis (HP:0012384)5.73375316
9Absent/shortened dynein arms (HP:0200106)5.54631474
10Dynein arm defect of respiratory motile cilia (HP:0012255)5.54631474
11Abnormal ciliary motility (HP:0012262)5.53724534
12Abnormality of renin-angiotensin system (HP:0000847)5.53200438
13Nasal polyposis (HP:0100582)4.95348310
14Abnormality of the nasal mucosa (HP:0000433)4.94753039
15Bronchiectasis (HP:0002110)4.84552694
16Metabolic alkalosis (HP:0200114)4.76484376
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.70742815
18Flat acetabular roof (HP:0003180)4.43540674
19Abnormality of chloride homeostasis (HP:0011422)4.41933112
20Malnutrition (HP:0004395)4.34903620
21Hyperaldosteronism (HP:0000859)4.24382020
22Alkalosis (HP:0001948)4.16246694
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.75812313
24Bronchitis (HP:0012387)3.50695092
25Hyponatremia (HP:0002902)3.37561347
26Ileus (HP:0002595)3.11739183
27Hyperkalemia (HP:0002153)3.08992795
28Systemic lupus erythematosus (HP:0002725)2.97419094
29Right ventricular cardiomyopathy (HP:0011663)2.95718658
30Recurrent sinusitis (HP:0011108)2.94186756
31Abnormality of proline metabolism (HP:0010907)2.86545572
32Hydroxyprolinuria (HP:0003080)2.86545572
33Abdominal distention (HP:0003270)2.85299106
34Hemorrhage of the eye (HP:0011885)2.82129878
35Fat malabsorption (HP:0002630)2.75972561
36Chronic sinusitis (HP:0011109)2.74309285
37Hypokalemia (HP:0002900)2.72000185
38Chronic diarrhea (HP:0002028)2.71289906
39Chronic otitis media (HP:0000389)2.56999248
40Abnormality of sodium homeostasis (HP:0010931)2.55623558
41Abnormality of potassium homeostasis (HP:0011042)2.53547704
42Renal salt wasting (HP:0000127)2.50929487
43Pili torti (HP:0003777)2.48118625
44Flattened epiphyses (HP:0003071)2.44298912
45Recurrent otitis media (HP:0000403)2.41970098
46Villous atrophy (HP:0011473)2.38099648
47Abnormality of small intestinal villus morphology (HP:0011472)2.38099648
48Hypotension (HP:0002615)2.34670612
49Intrahepatic cholestasis (HP:0001406)2.34286884
50Infertility (HP:0000789)2.34144844
51Adrenal overactivity (HP:0002717)2.33817416
52Male infertility (HP:0003251)2.33458787
53Congenital sensorineural hearing impairment (HP:0008527)2.32050797
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.28956843
55Spinal cord compression (HP:0002176)2.19929900
56Conjugated hyperbilirubinemia (HP:0002908)2.19400083
57Eczematoid dermatitis (HP:0000976)2.18561604
58Abnormal tarsal ossification (HP:0008369)2.13737239
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.12822400
60Abnormality of vitamin metabolism (HP:0100508)2.12745180
61Dehydration (HP:0001944)2.12318660
62Abnormality of vitamin B metabolism (HP:0004340)2.09891203
63Abnormality of carpal bone ossification (HP:0006257)2.06675079
64Hyperparathyroidism (HP:0000843)2.06207913
65Neonatal short-limb short stature (HP:0008921)2.06079322
66Ventricular fibrillation (HP:0001663)2.05054955
67Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.99854892
68Abnormal hair laboratory examination (HP:0003328)1.99485010
69Widely patent fontanelles and sutures (HP:0004492)1.95076236
70Glomerulonephritis (HP:0000099)1.89821233
71Syncope (HP:0001279)1.88713233
72Visceral angiomatosis (HP:0100761)1.88684666
73Abnormality of the distal phalanges of the toes (HP:0010182)1.85254511
74Abnormal vertebral ossification (HP:0100569)1.85003487
75Abnormality of complement system (HP:0005339)1.80740530
76Hyperphosphatemia (HP:0002905)1.79753312
77Thin bony cortex (HP:0002753)1.79438749
78Complement deficiency (HP:0004431)1.78232718
79Growth hormone excess (HP:0000845)1.74080453
80Nephritis (HP:0000123)1.73778907
81Atelectasis (HP:0100750)1.72705929
82Recurrent bronchitis (HP:0002837)1.70550725
83Abnormal biliary tract morphology (HP:0012440)1.66581102
84Hyperammonemia (HP:0001987)1.64142372
85Hemangiomatosis (HP:0007461)1.62341603
86Aplasia/hypoplasia of the femur (HP:0005613)1.61783269
87Focal segmental glomerulosclerosis (HP:0000097)1.56647512
88Flat capital femoral epiphysis (HP:0003370)1.56570542
89Renal tubular acidosis (HP:0001947)1.55582601
90Abnormal hand bone ossification (HP:0010660)1.55362472
91Severe short stature (HP:0003510)1.53607552
92Abnormal ossification of hand bones (HP:0005921)1.52293181
93Vascular calcification (HP:0004934)1.51879173
94Mildly elevated creatine phosphokinase (HP:0008180)1.51497757
95Abnormality of the 1st metacarpal (HP:0010009)1.51313165
96Steatorrhea (HP:0002570)1.49441163
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.48792594
98Dicarboxylic aciduria (HP:0003215)1.48792594
99Protuberant abdomen (HP:0001538)1.46767211
100Premature loss of primary teeth (HP:0006323)1.43907795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.42629336
2MST1R5.34004512
3ACVR1B4.67801365
4MAPK154.03795024
5RIPK13.99011089
6ERN13.24922075
7PIK3CA3.13762623
8LMTK23.13098894
9MST42.48691343
10EPHB22.08954752
11STK242.05378150
12MET1.96183681
13PRKG21.91592094
14STK391.84814945
15MAP3K21.74462167
16PTK61.69388411
17SMG11.61045489
18MAP3K101.57659656
19TESK11.53054182
20EPHB11.46677247
21MAP3K121.44818831
22EPHA31.35838526
23OXSR11.29886871
24RIPK41.28111029
25FGFR41.27324595
26MAPKAPK31.23337627
27MYLK1.19894149
28TYK21.08993930
29CSK1.05414566
30TAOK11.04826381
31GRK61.04467166
32MAP3K31.03308383
33MAP2K21.03285492
34TRIB30.99585998
35DDR20.95651982
36TESK20.95383187
37NME10.94535888
38MATK0.90865578
39CDC42BPA0.87901662
40ERBB20.87805954
41PDPK10.85302597
42MAP3K10.84456273
43TBK10.83915224
44FGFR30.82006746
45FER0.74035378
46PAK40.72255443
47ZAP700.69609720
48PRPF4B0.68649047
49PRKAA20.64861287
50ABL20.64348758
51MAP2K60.63584123
52WNK40.62555575
53LRRK20.61800351
54MAP3K110.60769838
55EEF2K0.57335348
56PRKCI0.56715461
57NLK0.56258452
58PDK20.56117262
59MAP4K10.50448621
60PTK20.47557364
61DMPK0.47261910
62MAPK110.44546826
63PDK10.44515682
64IRAK10.44224286
65NEK60.43570939
66SRC0.42395634
67DYRK1B0.41415214
68PRKCA0.39243537
69PRKCD0.38223917
70CAMK2D0.37442580
71RET0.36131637
72ICK0.34073680
73FYN0.32636925
74BMPR20.32425074
75PRKACG0.32232107
76KSR20.31274861
77RPS6KA20.30736276
78CDK190.30243365
79CAMK2G0.30048134
80IKBKE0.29121840
81EPHA40.26737430
82MAPKAPK20.26714244
83PRKCQ0.25886495
84BMX0.22317072
85JAK20.21957162
86PIM20.21550182
87TTK0.21299022
88LYN0.20156246
89MAP2K10.20044434
90BCR0.19084395
91PRKCZ0.19014124
92YES10.18734721
93CDK60.18640784
94JAK10.18315899
95GRK10.18097472
96IGF1R0.17481720
97BLK0.16477360
98MAP3K140.15751121
99MAP3K70.14865235
100PKN20.14757373

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.28863907
2Sulfur metabolism_Homo sapiens_hsa009203.46521600
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.06147282
4Histidine metabolism_Homo sapiens_hsa003402.95800563
5Fat digestion and absorption_Homo sapiens_hsa049752.80405126
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68658643
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60650216
8Caffeine metabolism_Homo sapiens_hsa002322.56121282
9Nitrogen metabolism_Homo sapiens_hsa009102.50874338
10Chemical carcinogenesis_Homo sapiens_hsa052042.43757397
11Mineral absorption_Homo sapiens_hsa049782.37892839
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33736863
13Arginine biosynthesis_Homo sapiens_hsa002202.10579870
14Retinol metabolism_Homo sapiens_hsa008302.08939196
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06429837
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03859757
17Renin-angiotensin system_Homo sapiens_hsa046141.95397398
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91805989
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86964282
20Vitamin digestion and absorption_Homo sapiens_hsa049771.82632264
21Phenylalanine metabolism_Homo sapiens_hsa003601.77726659
22Fructose and mannose metabolism_Homo sapiens_hsa000511.73428788
23Fatty acid degradation_Homo sapiens_hsa000711.70334974
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.59789656
25Starch and sucrose metabolism_Homo sapiens_hsa005001.58015321
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.54218418
27Tyrosine metabolism_Homo sapiens_hsa003501.45315711
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43499197
29PPAR signaling pathway_Homo sapiens_hsa033201.42326306
30Glutathione metabolism_Homo sapiens_hsa004801.35860268
31Bile secretion_Homo sapiens_hsa049761.33741882
32Linoleic acid metabolism_Homo sapiens_hsa005911.31224785
33Protein digestion and absorption_Homo sapiens_hsa049741.27435369
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.23132013
35Pancreatic secretion_Homo sapiens_hsa049721.22636377
36Asthma_Homo sapiens_hsa053101.19281758
37Arginine and proline metabolism_Homo sapiens_hsa003301.16139842
38Arachidonic acid metabolism_Homo sapiens_hsa005901.12596465
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12588917
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09198407
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08025008
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06494210
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03704946
44Galactose metabolism_Homo sapiens_hsa000521.03118329
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99462718
46Allograft rejection_Homo sapiens_hsa053300.92191396
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.91060466
48Glycerolipid metabolism_Homo sapiens_hsa005610.90978168
49Other glycan degradation_Homo sapiens_hsa005110.89100458
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88231820
51Autoimmune thyroid disease_Homo sapiens_hsa053200.85869686
52Tryptophan metabolism_Homo sapiens_hsa003800.84764564
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82992394
54Graft-versus-host disease_Homo sapiens_hsa053320.80974631
55Staphylococcus aureus infection_Homo sapiens_hsa051500.80756417
56Sphingolipid metabolism_Homo sapiens_hsa006000.79394549
57Tight junction_Homo sapiens_hsa045300.79335296
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.76881007
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68337129
60Hepatitis C_Homo sapiens_hsa051600.66234953
61Type I diabetes mellitus_Homo sapiens_hsa049400.65341183
62beta-Alanine metabolism_Homo sapiens_hsa004100.61570010
63Peroxisome_Homo sapiens_hsa041460.59937832
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57908476
65Sulfur relay system_Homo sapiens_hsa041220.54783686
66Ether lipid metabolism_Homo sapiens_hsa005650.52299320
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.47329162
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47149720
69Antigen processing and presentation_Homo sapiens_hsa046120.44529775
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41002842
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40227131
72Pertussis_Homo sapiens_hsa051330.39614849
73Renin secretion_Homo sapiens_hsa049240.38852459
74Thyroid hormone synthesis_Homo sapiens_hsa049180.36766554
75Leishmaniasis_Homo sapiens_hsa051400.36364432
76Fatty acid metabolism_Homo sapiens_hsa012120.32223916
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31984456
78Insulin resistance_Homo sapiens_hsa049310.24685878
79Amoebiasis_Homo sapiens_hsa051460.23030701
80Butanoate metabolism_Homo sapiens_hsa006500.21754948
81Vibrio cholerae infection_Homo sapiens_hsa051100.21197558
82Viral myocarditis_Homo sapiens_hsa054160.20982766
83Salmonella infection_Homo sapiens_hsa051320.20620497
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20519751
85Metabolic pathways_Homo sapiens_hsa011000.17744386
86Salivary secretion_Homo sapiens_hsa049700.16164527
87Influenza A_Homo sapiens_hsa051640.15767224
88Toxoplasmosis_Homo sapiens_hsa051450.15581114
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.14755626
90Pyruvate metabolism_Homo sapiens_hsa006200.14697688
91ABC transporters_Homo sapiens_hsa020100.14171369
92Hematopoietic cell lineage_Homo sapiens_hsa046400.14137401
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13408986
94Fatty acid biosynthesis_Homo sapiens_hsa000610.12806757
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.12006343
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11734656
97Tuberculosis_Homo sapiens_hsa051520.10882496
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09701074
99Choline metabolism in cancer_Homo sapiens_hsa052310.07884732
100Complement and coagulation cascades_Homo sapiens_hsa046100.06898880

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