FAM45A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)4.89919499
2rhodopsin mediated signaling pathway (GO:0016056)4.56577187
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.54771681
4respiratory chain complex IV assembly (GO:0008535)4.31044526
5chromatin remodeling at centromere (GO:0031055)4.19856331
6piRNA metabolic process (GO:0034587)4.17932772
7cilium or flagellum-dependent cell motility (GO:0001539)4.17638903
8chaperone-mediated protein transport (GO:0072321)4.06288801
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05692655
10cytochrome complex assembly (GO:0017004)3.91347724
11platelet dense granule organization (GO:0060155)3.89818044
12microtubule depolymerization (GO:0007019)3.78853396
13protein complex biogenesis (GO:0070271)3.76399484
14rRNA modification (GO:0000154)3.74036631
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71025012
16ATP synthesis coupled proton transport (GO:0015986)3.71025012
17positive regulation of mitochondrial fission (GO:0090141)3.68815951
18water-soluble vitamin biosynthetic process (GO:0042364)3.67747315
19purine nucleobase biosynthetic process (GO:0009113)3.67272300
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63146627
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61460243
22mitochondrial respiratory chain complex assembly (GO:0033108)3.60585842
23GMP metabolic process (GO:0046037)3.56119478
24rRNA methylation (GO:0031167)3.55411883
25negative regulation of mast cell activation (GO:0033004)3.51653893
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51577450
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51577450
287-methylguanosine mRNA capping (GO:0006370)3.44681014
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.42994680
30NADH dehydrogenase complex assembly (GO:0010257)3.42994680
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42994680
32RNA capping (GO:0036260)3.38037919
337-methylguanosine RNA capping (GO:0009452)3.38037919
34DNA deamination (GO:0045006)3.37673043
35regulation of mitochondrial translation (GO:0070129)3.36139926
36DNA catabolic process, exonucleolytic (GO:0000738)3.32951000
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.29897004
38retinal cone cell development (GO:0046549)3.27243356
39multicellular organism reproduction (GO:0032504)3.25708797
40male meiosis (GO:0007140)3.24703543
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.22895736
42branched-chain amino acid catabolic process (GO:0009083)3.22657410
43axonemal dynein complex assembly (GO:0070286)3.09560551
44positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.08838798
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.08838798
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.08817301
47termination of RNA polymerase III transcription (GO:0006386)3.08817301
48protein deneddylation (GO:0000338)3.07471975
49fusion of sperm to egg plasma membrane (GO:0007342)3.05007656
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04499234
51regulation of mitotic spindle checkpoint (GO:1903504)3.04499234
52L-fucose catabolic process (GO:0042355)3.04117150
53fucose catabolic process (GO:0019317)3.04117150
54L-fucose metabolic process (GO:0042354)3.04117150
55photoreceptor cell maintenance (GO:0045494)3.03877780
56DNA replication-independent nucleosome organization (GO:0034724)3.01774297
57DNA replication-independent nucleosome assembly (GO:0006336)3.01774297
58histone mRNA metabolic process (GO:0008334)3.01038977
59motile cilium assembly (GO:0044458)3.00068626
60acrosome reaction (GO:0007340)2.99279884
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99054580
62mannosylation (GO:0097502)2.97769396
63protein K6-linked ubiquitination (GO:0085020)2.96646392
64recombinational repair (GO:0000725)2.96359201
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95557482
66negative regulation of ligase activity (GO:0051352)2.95557482
67pseudouridine synthesis (GO:0001522)2.94194713
68microtubule polymerization or depolymerization (GO:0031109)2.93840338
69proteasome assembly (GO:0043248)2.93755503
70mitotic metaphase plate congression (GO:0007080)2.92683473
71double-strand break repair via homologous recombination (GO:0000724)2.89373194
72aldehyde catabolic process (GO:0046185)2.88859177
73cullin deneddylation (GO:0010388)2.88096010
74DNA methylation involved in gamete generation (GO:0043046)2.87613551
75maturation of 5.8S rRNA (GO:0000460)2.87470227
76establishment of integrated proviral latency (GO:0075713)2.87354219
77synaptonemal complex organization (GO:0070193)2.86793387
78cellular response to gamma radiation (GO:0071480)2.86725532
79positive regulation of cellular amide metabolic process (GO:0034250)2.86666091
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.86049217
81male meiosis I (GO:0007141)2.85932682
82protein neddylation (GO:0045116)2.85459793
83DNA damage response, detection of DNA damage (GO:0042769)2.83324565
84synaptonemal complex assembly (GO:0007130)2.82812285
85regulation of hexokinase activity (GO:1903299)2.82018201
86regulation of glucokinase activity (GO:0033131)2.82018201
87phagosome maturation (GO:0090382)2.79912383
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78670867
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78034553
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78034553
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78034553
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76490527
93protein-cofactor linkage (GO:0018065)2.75634956
94vitamin transmembrane transport (GO:0035461)2.75148556
95transferrin transport (GO:0033572)2.75005396
96eye photoreceptor cell development (GO:0042462)2.73870994
97termination of RNA polymerase I transcription (GO:0006363)2.73670945
98pantothenate metabolic process (GO:0015939)2.73661091
99photoreceptor cell development (GO:0042461)2.73141962
100DNA demethylation (GO:0080111)2.72199103
101meiosis I (GO:0007127)2.71193448
102preassembly of GPI anchor in ER membrane (GO:0016254)2.70790396
103DNA double-strand break processing (GO:0000729)2.69508933
104transcription from RNA polymerase I promoter (GO:0006360)2.69439158
105regulation of spindle checkpoint (GO:0090231)2.69222019
106regulation of helicase activity (GO:0051095)2.69072995
107intracellular pH reduction (GO:0051452)2.68683275
108DNA synthesis involved in DNA repair (GO:0000731)2.68333042
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67726352
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67726352
111respiratory electron transport chain (GO:0022904)2.67363800
112L-methionine salvage (GO:0071267)2.67239451
113L-methionine biosynthetic process (GO:0071265)2.67239451
114amino acid salvage (GO:0043102)2.67239451
115blastocyst development (GO:0001824)2.67109575
116nonmotile primary cilium assembly (GO:0035058)2.66854027
117electron transport chain (GO:0022900)2.66266153
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66263008
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65493133
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65493133
121isotype switching (GO:0045190)2.65493133
122superoxide anion generation (GO:0042554)2.65352527
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65323963
124DNA ligation (GO:0006266)2.65107643
125ferric iron transport (GO:0015682)2.64997345
126trivalent inorganic cation transport (GO:0072512)2.64997345
127replication fork processing (GO:0031297)2.64794281
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64279680
129amino sugar catabolic process (GO:0046348)2.64013594
130positive regulation of ligase activity (GO:0051351)2.63138708
131cell wall macromolecule catabolic process (GO:0016998)2.62909784
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62634263
133protein localization to cilium (GO:0061512)2.61644516
134peptidyl-histidine modification (GO:0018202)2.61489703
135adenosine metabolic process (GO:0046085)2.61221257
136glycosphingolipid catabolic process (GO:0046479)2.61030050
137protein K11-linked ubiquitination (GO:0070979)2.59510060
138transcription initiation from RNA polymerase I promoter (GO:0006361)2.58439149
139regulation of cilium movement (GO:0003352)2.58130748
140protein localization to mitochondrion (GO:0070585)2.57781322
141signal transduction involved in cell cycle checkpoint (GO:0072395)2.56719684
142signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56589423
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.56589423
144regulation of meiosis I (GO:0060631)2.56441878
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55908252
146protein heterotetramerization (GO:0051290)2.55705508
147response to X-ray (GO:0010165)2.55304348
148oxidative phosphorylation (GO:0006119)2.54794213
149tRNA processing (GO:0008033)2.54665535
150protein targeting to mitochondrion (GO:0006626)2.53375300
151sperm motility (GO:0030317)2.53274043
152negative regulation of systemic arterial blood pressure (GO:0003085)2.52403319
153positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.52223565
154resolution of meiotic recombination intermediates (GO:0000712)2.52129605
155transcription elongation from RNA polymerase II promoter (GO:0006368)2.51675857
156negative regulation of dendrite morphogenesis (GO:0050774)2.51084099
157dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.50412702
158nucleotide-sugar biosynthetic process (GO:0009226)2.49502177
159deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.49458977
160acrosome assembly (GO:0001675)2.49415531
161CENP-A containing nucleosome assembly (GO:0034080)2.49087310
162folic acid transport (GO:0015884)2.48785230
163anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46818478
164negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.45148800
165sperm-egg recognition (GO:0035036)2.44670948
166meiotic chromosome segregation (GO:0045132)2.43915962
167negative regulation of macrophage differentiation (GO:0045650)2.42070987
168microglial cell activation (GO:0001774)2.41984579
169regulation of mitochondrial fission (GO:0090140)2.41184564
170regulation of germinal center formation (GO:0002634)2.40969322
171nucleobase biosynthetic process (GO:0046112)2.40776357
172DNA-templated transcription, elongation (GO:0006354)2.38636954
173epithelial cilium movement (GO:0003351)2.38209341
174histone exchange (GO:0043486)2.38057282
175regulation of cellular amino acid metabolic process (GO:0006521)2.37816170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35169308
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.27504411
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.22331130
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09936646
5ZNF274_21170338_ChIP-Seq_K562_Hela3.02072179
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99013471
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.84245653
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83832858
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70773450
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64707274
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44626789
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27969729
13GBX2_23144817_ChIP-Seq_PC3_Human2.26934250
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.25545952
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.20969162
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14902355
17VDR_22108803_ChIP-Seq_LS180_Human2.12362349
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09484205
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08845991
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.07883103
21FOXP3_21729870_ChIP-Seq_TREG_Human2.04803378
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.00635764
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00079596
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.84703083
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83974257
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.81383354
27NANOG_18555785_Chip-Seq_ESCs_Mouse1.80845708
28STAT3_18555785_Chip-Seq_ESCs_Mouse1.79237444
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75617906
30TAF15_26573619_Chip-Seq_HEK293_Human1.74578296
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.74155166
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70981620
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70839026
34EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.69477549
35P53_22387025_ChIP-Seq_ESCs_Mouse1.67040854
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66749959
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65662553
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.63911315
39IGF1R_20145208_ChIP-Seq_DFB_Human1.63442014
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.62400415
41ER_23166858_ChIP-Seq_MCF-7_Human1.61522118
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.60538322
43NMYC_18555785_Chip-Seq_ESCs_Mouse1.59819786
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57923955
45RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56823045
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.56609785
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55684088
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54197369
49P300_19829295_ChIP-Seq_ESCs_Human1.53980882
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.53341264
51MYC_18940864_ChIP-ChIP_HL60_Human1.53004871
52OCT4_18555785_Chip-Seq_ESCs_Mouse1.50238183
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.49838796
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49790314
55P300_18555785_Chip-Seq_ESCs_Mouse1.48546713
56SMAD1_18555785_Chip-Seq_ESCs_Mouse1.45757018
57PU1_27457419_Chip-Seq_LIVER_Mouse1.45035732
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.43662508
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42744574
60EWS_26573619_Chip-Seq_HEK293_Human1.41785976
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41622338
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40884604
63ZFX_18555785_Chip-Seq_ESCs_Mouse1.40386863
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37032560
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.36554775
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34664754
67ELK1_19687146_ChIP-ChIP_HELA_Human1.34664247
68VDR_23849224_ChIP-Seq_CD4+_Human1.34622570
69FUS_26573619_Chip-Seq_HEK293_Human1.33529464
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33014997
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32882819
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32356167
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.31726768
74ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30788282
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30578098
76TP53_22573176_ChIP-Seq_HFKS_Human1.27909908
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27036967
78HTT_18923047_ChIP-ChIP_STHdh_Human1.26324888
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.24640011
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23452679
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23279784
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23098592
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22212603
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22119113
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21078046
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20061271
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19923095
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19858511
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19745121
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.19741258
91* SMAD4_21799915_ChIP-Seq_A2780_Human1.18563282
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17008128
93BCAT_22108803_ChIP-Seq_LS180_Human1.16350602
94* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15990918
95GABP_19822575_ChIP-Seq_HepG2_Human1.15025586
96DCP1A_22483619_ChIP-Seq_HELA_Human1.14422561
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14267181
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14253468
99NANOG_16153702_ChIP-ChIP_HESCs_Human1.14031687
100STAT1_17558387_ChIP-Seq_HELA_Human1.13150828
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11242803
102SOX2_19829295_ChIP-Seq_ESCs_Human1.10185827
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09173691
104CBP_20019798_ChIP-Seq_JUKART_Human1.08254300
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08254300
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07456148
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07046768
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.07046768
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06962140
110AR_20517297_ChIP-Seq_VCAP_Human1.05686035
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.04873470
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04724774
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02956096
114EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02941414
115JUN_21703547_ChIP-Seq_K562_Human1.02832121
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02480171
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01386119
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00743615
119IRF1_19129219_ChIP-ChIP_H3396_Human0.98774577
120TCF4_22108803_ChIP-Seq_LS180_Human0.98732529
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97542713
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96285677
123STAT3_23295773_ChIP-Seq_U87_Human0.95906088
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95544695
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.95359802
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94724771
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93802099
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93773271
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93116896
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92656252
131RNF2_27304074_Chip-Seq_NSC_Mouse0.92620910
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92562271
133SALL4_22934838_ChIP-ChIP_CD34+_Human0.91877914
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91012234
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90849398
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90792770
137THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90751349
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90668502
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90271368
140ETV1_20927104_ChIP-Seq_GIST48_Human0.90269542
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.90027931
142KDM2B_26808549_Chip-Seq_REH_Human0.89195265
143MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88509869
144NANOG_19829295_ChIP-Seq_ESCs_Human0.88468305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.01564700
2MP0008260_abnormal_autophagy3.56270060
3MP0005084_abnormal_gallbladder_morpholo3.26209771
4MP0003806_abnormal_nucleotide_metabolis3.25401762
5MP0005410_abnormal_fertilization3.14099909
6MP0003718_maternal_effect3.00798021
7MP0009697_abnormal_copulation2.92149196
8MP0008058_abnormal_DNA_repair2.82751029
9MP0002876_abnormal_thyroid_physiology2.82434328
10MP0005551_abnormal_eye_electrophysiolog2.70085167
11MP0002938_white_spotting2.69783626
12MP0003693_abnormal_embryo_hatching2.67247531
13MP0006054_spinal_hemorrhage2.63893764
14MP0001188_hyperpigmentation2.56974457
15MP0008877_abnormal_DNA_methylation2.42312684
16MP0005174_abnormal_tail_pigmentation2.34666439
17MP0005075_abnormal_melanosome_morpholog2.28151554
18MP0003950_abnormal_plasma_membrane2.22870157
19MP0003890_abnormal_embryonic-extraembry2.20470657
20MP0002163_abnormal_gland_morphology2.17434757
21MP0005171_absent_coat_pigmentation2.15465059
22MP0002638_abnormal_pupillary_reflex2.12864949
23MP0001542_abnormal_bone_strength2.09281000
24MP0001764_abnormal_homeostasis2.02783346
25MP0010386_abnormal_urinary_bladder1.87872332
26MP0002132_abnormal_respiratory_system1.81712861
27MP0001529_abnormal_vocalization1.81597578
28MP0001293_anophthalmia1.80371481
29MP0009046_muscle_twitch1.78457329
30MP0003111_abnormal_nucleus_morphology1.76559484
31MP0005085_abnormal_gallbladder_physiolo1.75447922
32MP0008875_abnormal_xenobiotic_pharmacok1.74900391
33MP0001984_abnormal_olfaction1.74635726
34MP0001929_abnormal_gametogenesis1.71659295
35MP0001835_abnormal_antigen_presentation1.69506539
36MP0002160_abnormal_reproductive_system1.67507064
37MP0005253_abnormal_eye_physiology1.66928025
38MP0003698_abnormal_male_reproductive1.65744596
39MP0006036_abnormal_mitochondrial_physio1.65329819
40MP0005451_abnormal_body_composition1.61305176
41MP0006292_abnormal_olfactory_placode1.57734075
42MP0000015_abnormal_ear_pigmentation1.57613039
43MP0002735_abnormal_chemical_nociception1.57281215
44MP0005646_abnormal_pituitary_gland1.56459361
45MP0002277_abnormal_respiratory_mucosa1.54890011
46MP0004957_abnormal_blastocyst_morpholog1.54295388
47MP0002210_abnormal_sex_determination1.54173298
48MP0004133_heterotaxia1.52727709
49MP0008057_abnormal_DNA_replication1.52424632
50MP0004782_abnormal_surfactant_physiolog1.50292575
51MP0003786_premature_aging1.49833955
52MP0005423_abnormal_somatic_nervous1.47662969
53MP0010094_abnormal_chromosome_stability1.46325389
54MP0002736_abnormal_nociception_after1.45100417
55MP0001485_abnormal_pinna_reflex1.44701298
56MP0005310_abnormal_salivary_gland1.44024233
57MP0006035_abnormal_mitochondrial_morpho1.43736238
58MP0001905_abnormal_dopamine_level1.41111402
59MP0003787_abnormal_imprinting1.39552791
60MP0008007_abnormal_cellular_replicative1.38044551
61MP0003567_abnormal_fetal_cardiomyocyte1.37941872
62MP0005379_endocrine/exocrine_gland_phen1.36824804
63MP0005389_reproductive_system_phenotype1.36726245
64MP0004147_increased_porphyrin_level1.34107980
65MP0002148_abnormal_hypersensitivity_rea1.32312330
66MP0003121_genomic_imprinting1.30555728
67MP0000516_abnormal_urinary_system1.30286703
68MP0005367_renal/urinary_system_phenotyp1.30286703
69MP0002095_abnormal_skin_pigmentation1.28267627
70MP0004142_abnormal_muscle_tone1.27961032
71MP0005395_other_phenotype1.27224797
72MP0000566_synostosis1.25543746
73MP0003195_calcinosis1.24486904
74MP0005365_abnormal_bile_salt1.24405252
75MP0001119_abnormal_female_reproductive1.24218282
76MP0002102_abnormal_ear_morphology1.23994603
77MP0003252_abnormal_bile_duct1.23877736
78MP0001177_atelectasis1.22889111
79MP0005671_abnormal_response_to1.21690270
80MP0008932_abnormal_embryonic_tissue1.21103180
81MP0005645_abnormal_hypothalamus_physiol1.19561986
82MP0003186_abnormal_redox_activity1.18472615
83MP0005332_abnormal_amino_acid1.17166172
84MP0003011_delayed_dark_adaptation1.17071149
85MP0000372_irregular_coat_pigmentation1.16835524
86MP0001963_abnormal_hearing_physiology1.15552406
87MP0000653_abnormal_sex_gland1.15172083
88MP0002734_abnormal_mechanical_nocicepti1.14449252
89MP0002419_abnormal_innate_immunity1.11733509
90MP0001145_abnormal_male_reproductive1.11217243
91MP0005408_hypopigmentation1.08612874
92MP0003656_abnormal_erythrocyte_physiolo1.08174401
93MP0001661_extended_life_span1.07247075
94MP0002837_dystrophic_cardiac_calcinosis1.04180009
95MP0008872_abnormal_physiological_respon1.03398759
96MP0003136_yellow_coat_color0.99748629
97MP0001968_abnormal_touch/_nociception0.99579250
98MP0001919_abnormal_reproductive_system0.99552525
99MP0009333_abnormal_splenocyte_physiolog0.98911463
100MP0003077_abnormal_cell_cycle0.98759965
101MP0002161_abnormal_fertility/fecundity0.97835706
102MP0005058_abnormal_lysosome_morphology0.95562583
103MP0005647_abnormal_sex_gland0.95196441
104MP0002090_abnormal_vision0.95030224
105MP0002751_abnormal_autonomic_nervous0.94578063
106MP0004134_abnormal_chest_morphology0.93290748
107MP0002928_abnormal_bile_duct0.92520320
108MP0006082_CNS_inflammation0.91067085
109MP0000427_abnormal_hair_cycle0.90797935
110MP0001324_abnormal_eye_pigmentation0.90387117
111MP0006276_abnormal_autonomic_nervous0.88436238
112MP0002229_neurodegeneration0.88130633
113MP0001286_abnormal_eye_development0.87399642
114MP0003937_abnormal_limbs/digits/tail_de0.87382536
115MP0000647_abnormal_sebaceous_gland0.86762428
116MP0000681_abnormal_thyroid_gland0.86663923
117MP0003941_abnormal_skin_development0.85645482
118MP0001486_abnormal_startle_reflex0.83917422
119MP0002272_abnormal_nervous_system0.82529666
120MP0005636_abnormal_mineral_homeostasis0.82320820
121MP0003119_abnormal_digestive_system0.78863117
122MP0000358_abnormal_cell_content/0.78802231
123MP0005195_abnormal_posterior_eye0.78793257
124MP0002067_abnormal_sensory_capabilities0.78647018
125MP0002653_abnormal_ependyma_morphology0.77166758
126MP0008995_early_reproductive_senescence0.76655309
127MP0008873_increased_physiological_sensi0.74413149
128MP0004742_abnormal_vestibular_system0.72651206
129MP0010329_abnormal_lipoprotein_level0.71736218
130MP0003122_maternal_imprinting0.71682686
131MP0003879_abnormal_hair_cell0.71124405
132MP0009785_altered_susceptibility_to0.71123152
133MP0001501_abnormal_sleep_pattern0.70983247
134MP0004019_abnormal_vitamin_homeostasis0.70539303
135MP0003943_abnormal_hepatobiliary_system0.70284443
136MP0005083_abnormal_biliary_tract0.69739577
137MP0003724_increased_susceptibility_to0.69631750
138MP0000026_abnormal_inner_ear0.69312728
139MP0003880_abnormal_central_pattern0.69109143
140MP0000631_abnormal_neuroendocrine_gland0.68398327
141MP0002064_seizures0.68238655
142MP0001666_abnormal_nutrient_absorption0.68080633
143MP0000371_diluted_coat_color0.67891437
144MP0003690_abnormal_glial_cell0.67796019
145MP0000569_abnormal_digit_pigmentation0.67160741
146MP0009764_decreased_sensitivity_to0.66925282
147MP0006072_abnormal_retinal_apoptosis0.66873583
148MP0008004_abnormal_stomach_pH0.66427359
149MP0008789_abnormal_olfactory_epithelium0.65957000
150MP0005376_homeostasis/metabolism_phenot0.65409862
151MP0005394_taste/olfaction_phenotype0.62576608

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.05531558
2Medial flaring of the eyebrow (HP:0010747)3.70962616
3Pancreatic fibrosis (HP:0100732)3.58002336
4Methylmalonic acidemia (HP:0002912)3.56673788
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48435578
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42259726
7Birth length less than 3rd percentile (HP:0003561)3.32060192
8Congenital primary aphakia (HP:0007707)3.26283914
9Abnormal spermatogenesis (HP:0008669)3.21252581
10Azoospermia (HP:0000027)3.15175684
11Acute encephalopathy (HP:0006846)3.15083191
12Gait imbalance (HP:0002141)3.14708045
13Acute necrotizing encephalopathy (HP:0006965)3.12778383
14Nephrogenic diabetes insipidus (HP:0009806)3.11499060
15Chromsome breakage (HP:0040012)3.03423279
16Mitochondrial inheritance (HP:0001427)2.98530455
17Poor coordination (HP:0002370)2.95924344
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.95339163
19Absent/shortened dynein arms (HP:0200106)2.95339163
20True hermaphroditism (HP:0010459)2.94484663
21Methylmalonic aciduria (HP:0012120)2.91012664
22Submucous cleft hard palate (HP:0000176)2.83500394
23Bony spicule pigmentary retinopathy (HP:0007737)2.82615046
24Abolished electroretinogram (ERG) (HP:0000550)2.81627363
25Lipid accumulation in hepatocytes (HP:0006561)2.81299243
26Increased CSF lactate (HP:0002490)2.81194962
27Pancreatic cysts (HP:0001737)2.80063135
28Colon cancer (HP:0003003)2.79947390
29Abnormal rod and cone electroretinograms (HP:0008323)2.76220917
30Abnormality of serum amino acid levels (HP:0003112)2.75806375
31Abnormality of methionine metabolism (HP:0010901)2.73414635
32Abnormality of aspartate family amino acid metabolism (HP:0010899)2.72987460
33Increased hepatocellular lipid droplets (HP:0006565)2.71967823
34Progressive macrocephaly (HP:0004481)2.71267146
35Prostate neoplasm (HP:0100787)2.67765822
36Abnormal hair whorl (HP:0010721)2.66149935
37Attenuation of retinal blood vessels (HP:0007843)2.64749741
38Hepatocellular necrosis (HP:0001404)2.61353949
39Abnormal mitochondria in muscle tissue (HP:0008316)2.59501276
40Impulsivity (HP:0100710)2.54075876
41Prolonged neonatal jaundice (HP:0006579)2.52596467
42Abnormal protein glycosylation (HP:0012346)2.52352837
43Abnormal glycosylation (HP:0012345)2.52352837
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52352837
45Abnormal protein N-linked glycosylation (HP:0012347)2.52352837
46Renal Fanconi syndrome (HP:0001994)2.49240727
47Hypothermia (HP:0002045)2.48642746
48Hepatic necrosis (HP:0002605)2.47604654
49Neoplasm of the adrenal gland (HP:0100631)2.46181418
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.45634578
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41921486
52Abnormal biliary tract physiology (HP:0012439)2.39355706
53Bile duct proliferation (HP:0001408)2.39355706
54Abnormal respiratory motile cilium morphology (HP:0005938)2.38905920
55Abnormal respiratory epithelium morphology (HP:0012253)2.38905920
56Abnormality of glycine metabolism (HP:0010895)2.38440293
57Abnormality of serine family amino acid metabolism (HP:0010894)2.38440293
58Abnormal respiratory motile cilium physiology (HP:0012261)2.36885968
59Breast hypoplasia (HP:0003187)2.36564341
60Pigmentary retinal degeneration (HP:0001146)2.31873845
61Stomatitis (HP:0010280)2.31458911
62Abnormality of the preputium (HP:0100587)2.30828965
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30758855
64Irregular epiphyses (HP:0010582)2.29074945
65Cerebral edema (HP:0002181)2.28120321
66Osteomalacia (HP:0002749)2.27097826
67Meckel diverticulum (HP:0002245)2.26955078
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.26109203
69Genital tract atresia (HP:0001827)2.24677007
70Decreased central vision (HP:0007663)2.21176285
71Short nail (HP:0001799)2.21083703
72Vaginal atresia (HP:0000148)2.20898322
73Chorioretinal atrophy (HP:0000533)2.18810600
74Hyperglycinuria (HP:0003108)2.18194332
75Rhinitis (HP:0012384)2.17733572
76Lactic acidosis (HP:0003128)2.16487585
77Cerebral hypomyelination (HP:0006808)2.14868868
78Lethargy (HP:0001254)2.14259898
79Abnormal ciliary motility (HP:0012262)2.13925121
80Increased serum lactate (HP:0002151)2.13507164
81Abnormality of the pons (HP:0007361)2.12945725
82Abnormality of incisor morphology (HP:0011063)2.12827656
83Aplastic anemia (HP:0001915)2.12456232
84Abnormality of vitamin B metabolism (HP:0004340)2.10980439
85Abnormality of the ileum (HP:0001549)2.08949194
86Febrile seizures (HP:0002373)2.08817089
87Abnormality of the vitamin B12 metabolism (HP:0004341)2.08801508
88Neoplasm of the adrenal cortex (HP:0100641)2.08638307
89Abnormality of chromosome stability (HP:0003220)2.07996106
90Hypoplasia of the pons (HP:0012110)2.05671596
91Adrenal hypoplasia (HP:0000835)2.04757606
923-Methylglutaconic aciduria (HP:0003535)2.02539596
93Bifid tongue (HP:0010297)2.02362811
94Clubbing of toes (HP:0100760)2.02319525
95Rough bone trabeculation (HP:0100670)2.01235340
96Abnormal trabecular bone morphology (HP:0100671)2.00691855
97Degeneration of anterior horn cells (HP:0002398)2.00469518
98Abnormality of the anterior horn cell (HP:0006802)2.00469518
99Exertional dyspnea (HP:0002875)2.00349848
100Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00265762
101Abnormality of the fovea (HP:0000493)1.99937037
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.99896310
103Intestinal atresia (HP:0011100)1.98779593
104Aplasia/Hypoplasia of the lens (HP:0008063)1.98316971
105Septo-optic dysplasia (HP:0100842)1.97506161
106Alveolar cell carcinoma (HP:0006519)1.96003127
107Recurrent abscess formation (HP:0002722)1.95299852
108Chronic hepatic failure (HP:0100626)1.95216550
109Glycosuria (HP:0003076)1.93391465
110Abnormality of urine glucose concentration (HP:0011016)1.93391465
111Fair hair (HP:0002286)1.93286277
112Type I transferrin isoform profile (HP:0003642)1.91796309
113Astigmatism (HP:0000483)1.91601336
114Hypoplastic pelvis (HP:0008839)1.90132559
115Hypoplasia of the fovea (HP:0007750)1.89420626
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.89420626
117Progressive inability to walk (HP:0002505)1.89185313
118Type 2 muscle fiber atrophy (HP:0003554)1.89175247
119Abnormality of the labia minora (HP:0012880)1.88286235
120Recurrent bacterial skin infections (HP:0005406)1.87513355
121Short tibia (HP:0005736)1.87503157
122Retinitis pigmentosa (HP:0000510)1.86506213
123Abnormality of alanine metabolism (HP:0010916)1.86008782
124Hyperalaninemia (HP:0003348)1.86008782
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86008782
126Duplicated collecting system (HP:0000081)1.85994274
127Photophobia (HP:0000613)1.85374127
128Nephronophthisis (HP:0000090)1.85121915
129Severe visual impairment (HP:0001141)1.85087023
130Abnormality of midbrain morphology (HP:0002418)1.85014567
131Molar tooth sign on MRI (HP:0002419)1.85014567
132Abnormality of the renal collecting system (HP:0004742)1.84081842
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83496085
134Hypochromic microcytic anemia (HP:0004840)1.81974870
135Reduced antithrombin III activity (HP:0001976)1.80929148
136Bone marrow hypocellularity (HP:0005528)1.80811146
137Flat capital femoral epiphysis (HP:0003370)1.80677741
138Tubulointerstitial nephritis (HP:0001970)1.79194889
139Abnormality of renal resorption (HP:0011038)1.78341545
140Abnormal lung lobation (HP:0002101)1.78056390
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77981483
142Absent epiphyses (HP:0010577)1.77981483
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77589002
144Ureteral duplication (HP:0000073)1.77403775
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.74831008
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73949276
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73949276
148Stenosis of the external auditory canal (HP:0000402)1.73858258
149Sclerocornea (HP:0000647)1.73768231
150Renal cortical cysts (HP:0000803)1.73215120
151Aganglionic megacolon (HP:0002251)1.73202197
152Hypomagnesemia (HP:0002917)1.71693663
153Progressive visual loss (HP:0000529)1.70746975
154Small hand (HP:0200055)1.69962100
155Capillary hemangiomas (HP:0005306)1.69699552
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69132219
157Carpal bone hypoplasia (HP:0001498)1.68064927
158Focal motor seizures (HP:0011153)1.68037254
159Inability to walk (HP:0002540)1.67704958
160Segmental peripheral demyelination/remyelination (HP:0003481)1.67499820
161Median cleft lip (HP:0000161)1.67377068
162Broad foot (HP:0001769)1.65244719
163Hyperglycinemia (HP:0002154)1.63509674
164Microvesicular hepatic steatosis (HP:0001414)1.62628474
165Hypergonadotropic hypogonadism (HP:0000815)1.61886942
166Abnormality of male internal genitalia (HP:0000022)1.61857835
167Abnormality of the renal medulla (HP:0100957)1.61048394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT32.98625279
2VRK22.83293928
3CASK2.81028500
4CCNB12.71943887
5STK162.45424107
6PBK2.44281145
7TRIM282.33733738
8EIF2AK12.29775392
9ZAK2.27660000
10BRSK22.25833148
11MAP4K22.25054616
12PLK42.14936654
13SRPK12.02544184
14STK38L2.01921347
15BUB11.94896856
16BCR1.84755540
17BCKDK1.82536601
18IRAK31.81443272
19FRK1.78918394
20EIF2AK31.78212648
21EIF2AK21.76669691
22MAP2K71.76668918
23PDK21.75862040
24PDK41.70629284
25PDK31.70629284
26PLK31.70551411
27MAP3K121.69114502
28MKNK21.68856739
29IRAK41.64078447
30PLK21.63182832
31PINK11.58001040
32BMPR21.56041598
33MAP3K141.53814118
34WEE11.45969741
35NUAK11.32689411
36SGK21.28796960
37NEK61.28593630
38ERBB31.27742101
39DYRK21.27503158
40SIK31.26932568
41CDK31.25157060
42TSSK61.23593412
43ADRBK21.23548361
44VRK11.18182792
45MKNK11.17600689
46CDK191.14837770
47IRAK21.14564100
48BRSK11.12409966
49MST41.11729369
50TXK1.11076987
51TAF11.08264545
52BRAF1.07751483
53IRAK11.06601561
54GRK11.06062279
55NEK91.00616367
56TLK10.99655810
57STK240.99127315
58NEK10.98185922
59PRPF4B0.97264416
60PNCK0.94813257
61STK30.94635330
62CSNK1G10.92970253
63CAMKK20.92543244
64DYRK30.92013159
65SGK2230.91598149
66SGK4940.91598149
67GRK70.90125667
68NME10.86096633
69CDC70.86019667
70CSNK1G20.84635677
71PLK10.84624602
72CSNK1G30.83956727
73EPHA30.82346382
74YES10.80646641
75INSRR0.80372792
76TNIK0.79758655
77RIPK40.79275624
78BLK0.77861406
79MUSK0.77860863
80ERBB40.77353627
81ADRBK10.74653348
82PAK30.71080817
83CDK80.70193444
84BMPR1B0.69236828
85MAP3K40.67588515
86TTK0.67446692
87RPS6KA40.65378455
88TAOK30.65086715
89ARAF0.64850855
90RAF10.63559060
91CSNK1A1L0.62933645
92CHEK20.62024498
93STK390.61656395
94IKBKB0.60656748
95NLK0.60610534
96PRKCE0.60276685
97MAPKAPK50.58760495
98PTK2B0.58373951
99STK100.56654706
100OXSR10.55573282
101MAPK130.55356474
102PRKCG0.55266454
103ACVR1B0.54699048
104NEK20.54649058
105MARK30.53660203
106PIM20.52588217
107GRK50.52584507
108LMTK20.51005661
109WNK40.47164601
110SGK30.45353638
111TRPM70.44010515
112TEC0.42954658
113IKBKE0.40592954
114GRK60.40471225
115TGFBR10.39425266
116MAP3K50.38279480
117ATR0.33355462
118FGFR10.32917320
119WNK30.32871741
120PRKCQ0.32333597
121KIT0.31899524
122CSNK2A10.31444805
123MAP2K40.31157419
124PIK3CA0.30124194
125CSNK2A20.29970431
126MYLK0.28037135
127KDR0.27986211
128CHUK0.27704085
129RPS6KA50.27634643
130MATK0.27013007
131PRKCI0.26197286
132TYK20.25644833
133PKN10.25019464
134AURKA0.24230834
135LYN0.23983403
136TBK10.23916120
137AURKB0.23237790
138ATM0.23175589
139CAMK2A0.22645501

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.53794183
2Phototransduction_Homo sapiens_hsa047445.10353430
3Proteasome_Homo sapiens_hsa030503.19556918
4RNA polymerase_Homo sapiens_hsa030202.98727110
5Caffeine metabolism_Homo sapiens_hsa002322.69279031
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60593211
7Basal transcription factors_Homo sapiens_hsa030222.55744286
8Propanoate metabolism_Homo sapiens_hsa006402.50624938
9Collecting duct acid secretion_Homo sapiens_hsa049662.49369435
10Regulation of autophagy_Homo sapiens_hsa041402.47589040
11Parkinsons disease_Homo sapiens_hsa050122.45424807
12Fanconi anemia pathway_Homo sapiens_hsa034602.10976662
13Rheumatoid arthritis_Homo sapiens_hsa053232.04277023
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97516311
15Selenocompound metabolism_Homo sapiens_hsa004501.90986151
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.87949136
17Vitamin digestion and absorption_Homo sapiens_hsa049771.87582821
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.71516257
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70570950
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69289915
21Protein export_Homo sapiens_hsa030601.66452556
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64527366
23Homologous recombination_Homo sapiens_hsa034401.63346188
24Butanoate metabolism_Homo sapiens_hsa006501.54109657
25Synaptic vesicle cycle_Homo sapiens_hsa047211.52937838
26Purine metabolism_Homo sapiens_hsa002301.51700844
27Pyrimidine metabolism_Homo sapiens_hsa002401.50792463
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47998097
29Phagosome_Homo sapiens_hsa041451.44876763
30Sphingolipid metabolism_Homo sapiens_hsa006001.43029299
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41090464
32Graft-versus-host disease_Homo sapiens_hsa053321.39516649
33Steroid biosynthesis_Homo sapiens_hsa001001.37333371
34Alzheimers disease_Homo sapiens_hsa050101.32721791
35Cell cycle_Homo sapiens_hsa041101.32432955
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31289792
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30985233
38One carbon pool by folate_Homo sapiens_hsa006701.29900053
39Autoimmune thyroid disease_Homo sapiens_hsa053201.29837534
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28987640
41Chemical carcinogenesis_Homo sapiens_hsa052041.27040449
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.25951808
43Non-homologous end-joining_Homo sapiens_hsa034501.25107894
44Arachidonic acid metabolism_Homo sapiens_hsa005901.24132313
45Nitrogen metabolism_Homo sapiens_hsa009101.22435851
46Vibrio cholerae infection_Homo sapiens_hsa051101.21384959
47Allograft rejection_Homo sapiens_hsa053301.21344229
48Tryptophan metabolism_Homo sapiens_hsa003801.20612959
49Nucleotide excision repair_Homo sapiens_hsa034201.18477958
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15981812
51Folate biosynthesis_Homo sapiens_hsa007901.15221572
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14968090
53Nicotine addiction_Homo sapiens_hsa050331.14924677
54Pyruvate metabolism_Homo sapiens_hsa006201.12666929
55RNA transport_Homo sapiens_hsa030131.12368579
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11902634
57Ribosome_Homo sapiens_hsa030101.10163479
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09227828
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08872192
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.05013197
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04702466
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04570259
63Ether lipid metabolism_Homo sapiens_hsa005651.03143694
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01934154
65Lysosome_Homo sapiens_hsa041420.99881136
66Type I diabetes mellitus_Homo sapiens_hsa049400.98497474
67Fatty acid degradation_Homo sapiens_hsa000710.97089592
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96353096
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95848024
70Fatty acid elongation_Homo sapiens_hsa000620.95700561
71Spliceosome_Homo sapiens_hsa030400.92412072
72Sulfur relay system_Homo sapiens_hsa041220.90424441
73beta-Alanine metabolism_Homo sapiens_hsa004100.89983124
74Fatty acid metabolism_Homo sapiens_hsa012120.83440492
75Epstein-Barr virus infection_Homo sapiens_hsa051690.80244319
76RNA degradation_Homo sapiens_hsa030180.73635099
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72168707
78Oxidative phosphorylation_Homo sapiens_hsa001900.70530149
79Linoleic acid metabolism_Homo sapiens_hsa005910.70507215
80Circadian rhythm_Homo sapiens_hsa047100.69275025
81p53 signaling pathway_Homo sapiens_hsa041150.69133591
82Mismatch repair_Homo sapiens_hsa034300.67869208
83Other glycan degradation_Homo sapiens_hsa005110.66906554
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.66408216
85Pentose phosphate pathway_Homo sapiens_hsa000300.63564812
86Legionellosis_Homo sapiens_hsa051340.62869588
87Metabolic pathways_Homo sapiens_hsa011000.61377934
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59265540
89Staphylococcus aureus infection_Homo sapiens_hsa051500.58622609
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.55798537
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.54947649
92Influenza A_Homo sapiens_hsa051640.54561679
93Base excision repair_Homo sapiens_hsa034100.54143658
94Malaria_Homo sapiens_hsa051440.54027381
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.53243768
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52501123
97Herpes simplex infection_Homo sapiens_hsa051680.50449976
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49708703
99Taste transduction_Homo sapiens_hsa047420.49325310
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48090605
101Serotonergic synapse_Homo sapiens_hsa047260.47890792
102Huntingtons disease_Homo sapiens_hsa050160.47737496
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46198960
104Olfactory transduction_Homo sapiens_hsa047400.45484896
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44176778
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44101179
107Sulfur metabolism_Homo sapiens_hsa009200.43082756
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43020629
109Measles_Homo sapiens_hsa051620.42669063
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42449195
111DNA replication_Homo sapiens_hsa030300.40254322
112Tuberculosis_Homo sapiens_hsa051520.39845402
113Oocyte meiosis_Homo sapiens_hsa041140.39278231
114Fat digestion and absorption_Homo sapiens_hsa049750.38616269
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38067315
116Antigen processing and presentation_Homo sapiens_hsa046120.37797116
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37578319
118Fructose and mannose metabolism_Homo sapiens_hsa000510.37459318
119Glutathione metabolism_Homo sapiens_hsa004800.37391602
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36613516
121Retinol metabolism_Homo sapiens_hsa008300.36462398
122Morphine addiction_Homo sapiens_hsa050320.36418594
123N-Glycan biosynthesis_Homo sapiens_hsa005100.35922623
124Mineral absorption_Homo sapiens_hsa049780.35242636
125Asthma_Homo sapiens_hsa053100.35023743
126Inositol phosphate metabolism_Homo sapiens_hsa005620.32487522
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.32375228
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30445075
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30107087
130Cardiac muscle contraction_Homo sapiens_hsa042600.29856050
131Carbon metabolism_Homo sapiens_hsa012000.27194828
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26840958
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.26775623
134TGF-beta signaling pathway_Homo sapiens_hsa043500.26449305
135Peroxisome_Homo sapiens_hsa041460.25467193
136GABAergic synapse_Homo sapiens_hsa047270.24935645
137Primary immunodeficiency_Homo sapiens_hsa053400.23861690
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22953776
139Starch and sucrose metabolism_Homo sapiens_hsa005000.18482829
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18002093
141Hedgehog signaling pathway_Homo sapiens_hsa043400.14907015

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