FAM46C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)8.69455711
2porphyrin-containing compound biosynthetic process (GO:0006779)7.21979570
3tetrapyrrole biosynthetic process (GO:0033014)6.33219096
4heme biosynthetic process (GO:0006783)6.28380211
5multicellular organism reproduction (GO:0032504)6.26422125
6piRNA metabolic process (GO:0034587)5.92806511
7fusion of sperm to egg plasma membrane (GO:0007342)5.91761435
8sperm motility (GO:0030317)5.72268404
9porphyrin-containing compound metabolic process (GO:0006778)5.68868448
10regulation of B cell receptor signaling pathway (GO:0050855)5.53740326
11negative regulation of cell killing (GO:0031342)5.34773604
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34773604
13reproduction (GO:0000003)5.33289218
14microglial cell activation (GO:0001774)5.31984427
15sperm-egg recognition (GO:0035036)5.29178229
16erythrocyte maturation (GO:0043249)5.25890276
17cell wall macromolecule catabolic process (GO:0016998)5.18085919
18cell wall macromolecule metabolic process (GO:0044036)5.18085919
19acrosome assembly (GO:0001675)5.13539384
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07979928
21binding of sperm to zona pellucida (GO:0007339)4.97003017
22heme metabolic process (GO:0042168)4.83011586
23cell-cell recognition (GO:0009988)4.82069149
24regulation of gamma-delta T cell differentiation (GO:0045586)4.81131617
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.78924044
26regulation of gamma-delta T cell activation (GO:0046643)4.71436507
27hemoglobin metabolic process (GO:0020027)4.57876000
28negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.56197895
29acrosome reaction (GO:0007340)4.53730057
30response to methylmercury (GO:0051597)4.50707189
31spermatid development (GO:0007286)4.46758392
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40699090
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.40257411
34positive T cell selection (GO:0043368)4.40146462
35histone H3-K36 demethylation (GO:0070544)4.36640922
36phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.33072620
37negative T cell selection (GO:0043383)4.32716144
38motile cilium assembly (GO:0044458)4.27200913
39erythrocyte development (GO:0048821)4.26095935
40negative regulation of inclusion body assembly (GO:0090084)4.20765204
41plasma membrane fusion (GO:0045026)4.20474511
42positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.16868883
43mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.16868883
44negative thymic T cell selection (GO:0045060)4.12530653
45detection of molecule of bacterial origin (GO:0032490)4.12499396
46positive thymic T cell selection (GO:0045059)4.11759882
47positive regulation of granulocyte differentiation (GO:0030854)4.07811439
48regulation of beta-amyloid formation (GO:1902003)3.95404757
49tetrapyrrole metabolic process (GO:0033013)3.91112830
50male meiosis (GO:0007140)3.89882886
51positive regulation by symbiont of host defense response (GO:0052509)3.87013854
52modulation by symbiont of host defense response (GO:0052031)3.87013854
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87013854
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87013854
55positive regulation by organism of defense response of other organism involved in symbiotic interact3.87013854
56modulation by symbiont of host immune response (GO:0052553)3.87013854
57macrophage activation (GO:0042116)3.84742300
58single fertilization (GO:0007338)3.84473181
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80221356
60positive regulation of receptor recycling (GO:0001921)3.78580512
61histone mRNA catabolic process (GO:0071044)3.76197657
62cellular extravasation (GO:0045123)3.76177785
63negative regulation of T cell mediated immunity (GO:0002710)3.71365768
64regulation of necroptotic process (GO:0060544)3.70223219
65fertilization (GO:0009566)3.69157991
66B cell receptor signaling pathway (GO:0050853)3.65707501
67neutrophil mediated immunity (GO:0002446)3.65014956
68activated T cell proliferation (GO:0050798)3.64507587
69positive regulation of insulin receptor signaling pathway (GO:0046628)3.63823717
70negative regulation of B cell proliferation (GO:0030889)3.62690273
71negative regulation of lymphocyte mediated immunity (GO:0002707)3.60464200
72axonemal dynein complex assembly (GO:0070286)3.59596844
73myeloid leukocyte mediated immunity (GO:0002444)3.59438749
74macrophage activation involved in immune response (GO:0002281)3.57640373
75microtubule depolymerization (GO:0007019)3.55099966
76response to insecticide (GO:0017085)3.54596720
77chromosome condensation (GO:0030261)3.51358590
78regulation of acrosome reaction (GO:0060046)3.49357202
79protein targeting to Golgi (GO:0000042)3.48639284
80protein K48-linked deubiquitination (GO:0071108)3.47080593
81DNA methylation involved in gamete generation (GO:0043046)3.45917468
82regulation of female gonad development (GO:2000194)3.45530109
83establishment of protein localization to Golgi (GO:0072600)3.44768082
84monoubiquitinated protein deubiquitination (GO:0035520)3.44346354
85gene silencing by RNA (GO:0031047)3.42974938
86epithelial cilium movement (GO:0003351)3.42256403
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41835453
88synaptonemal complex organization (GO:0070193)3.41833375
89Golgi transport vesicle coating (GO:0048200)3.36880901
90COPI coating of Golgi vesicle (GO:0048205)3.36880901
91retrograde transport, vesicle recycling within Golgi (GO:0000301)3.36152269
92synaptonemal complex assembly (GO:0007130)3.35725554
93L-alpha-amino acid transmembrane transport (GO:1902475)3.34984514
94T cell migration (GO:0072678)3.32951947
95regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.30567013
96histone H3-K4 trimethylation (GO:0080182)3.25302422
97spermatogenesis (GO:0007283)3.25294534
98negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24733037
99citrulline biosynthetic process (GO:0019240)3.24231082
100male gamete generation (GO:0048232)3.23971284
101regulation of amyloid precursor protein catabolic process (GO:1902991)3.21965994
102positive regulation of cellular response to oxidative stress (GO:1900409)3.21501801
103positive regulation of response to oxidative stress (GO:1902884)3.21501801
104T cell selection (GO:0045058)3.19092732
105meiotic cell cycle (GO:0051321)3.16612766
106detection of external biotic stimulus (GO:0098581)3.14234748
107negative regulation of immunoglobulin mediated immune response (GO:0002890)3.13262584
108negative regulation of B cell mediated immunity (GO:0002713)3.13262584
109antigen processing and presentation of endogenous antigen (GO:0019883)3.12871000
110gamete generation (GO:0007276)3.12533211
111activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.11202453
112receptor recycling (GO:0001881)3.10866516
113DNA packaging (GO:0006323)3.10582598
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.08942426
115positive regulation of erythrocyte differentiation (GO:0045648)3.08261892
116regulation of B cell differentiation (GO:0045577)3.08189578
117protein K63-linked deubiquitination (GO:0070536)3.08064257
118ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.07152989
119response to interleukin-15 (GO:0070672)3.04422763
120erythrocyte differentiation (GO:0030218)3.03710179
121protein localization to chromosome, centromeric region (GO:0071459)3.03349915
122cellular response to ethanol (GO:0071361)3.03181634
123regulation of regulatory T cell differentiation (GO:0045589)3.02619111
124positive regulation of nuclease activity (GO:0032075)3.01652002
125response to arsenic-containing substance (GO:0046685)3.00835950
126negative regulation of adaptive immune response (GO:0002820)3.00137204
127cilium or flagellum-dependent cell motility (GO:0001539)2.99771081
128oocyte maturation (GO:0001556)2.99051493
129negative regulation of interleukin-12 production (GO:0032695)2.98027023
130positive regulation of humoral immune response (GO:0002922)2.97759522
131mitotic sister chromatid cohesion (GO:0007064)2.97450377
132histone H3-K9 demethylation (GO:0033169)2.96842211
133negative regulation of execution phase of apoptosis (GO:1900118)2.96749110
134mitotic chromosome condensation (GO:0007076)2.95850648
135regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95793132
136negative regulation of leukocyte mediated immunity (GO:0002704)2.95768541
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93867033
138detection of other organism (GO:0098543)2.93679999
139regulation of inositol phosphate biosynthetic process (GO:0010919)2.90033612
140oocyte development (GO:0048599)2.90015806
141cellular process involved in reproduction in multicellular organism (GO:0022412)2.88997964
142positive regulation of B cell differentiation (GO:0045579)2.87569743
143regulation of response to osmotic stress (GO:0047484)2.87489357
144regulation of cellular amide metabolic process (GO:0034248)2.86583159
145positive regulation of mitochondrial membrane permeability (GO:0035794)2.86216614
146regulation of inclusion body assembly (GO:0090083)2.85569328
147myeloid cell development (GO:0061515)2.85310305
148cellular response to unfolded protein (GO:0034620)2.84726856
149thymic T cell selection (GO:0045061)2.84588664
150regulation of platelet aggregation (GO:0090330)2.83917940
151myeloid cell activation involved in immune response (GO:0002275)2.83755853
152endoplasmic reticulum unfolded protein response (GO:0030968)2.82444718
153leukocyte aggregation (GO:0070486)2.81623302
154cellular response to epinephrine stimulus (GO:0071872)2.79847098
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79675661
156response to host immune response (GO:0052572)2.79675661
157germ cell development (GO:0007281)2.78346855
158regulation of nuclease activity (GO:0032069)2.76930645
159regulation of cilium movement (GO:0003352)2.76400163
160negative regulation of complement activation (GO:0045916)2.75712417
161respiratory burst (GO:0045730)2.75180277
162regulation of mRNA catabolic process (GO:0061013)2.74894696
163regulation of granulocyte differentiation (GO:0030852)2.74755938
164seminiferous tubule development (GO:0072520)2.74442925
165neutrophil activation involved in immune response (GO:0002283)2.74216678
166negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72545854
167negative regulation of T-helper cell differentiation (GO:0045623)2.72545854
168negative regulation of protein oligomerization (GO:0032460)2.72117363
169positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.71886285
170regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.71886285
171regulation of cilium assembly (GO:1902017)2.71431598
172protein K11-linked deubiquitination (GO:0035871)2.70076105
173response to lead ion (GO:0010288)2.69813730
174cellular response to topologically incorrect protein (GO:0035967)2.69745238
175gene silencing (GO:0016458)2.69532450
176negative regulation of organelle assembly (GO:1902116)2.68716622
177positive regulation of gamma-delta T cell activation (GO:0046645)2.67397909
178organic cation transport (GO:0015695)2.66942011
179hepatocyte apoptotic process (GO:0097284)2.63034150
180histone H2A ubiquitination (GO:0033522)2.62170509
181histone H2A monoubiquitination (GO:0035518)2.61953573
182positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61790508
183positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61790508
184positive regulation of mitotic sister chromatid separation (GO:1901970)2.61790508
185maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61436206
186cilium movement (GO:0003341)2.60543305
187natural killer cell mediated immunity (GO:0002228)2.59352208
188natural killer cell mediated cytotoxicity (GO:0042267)2.59352208
189meiotic nuclear division (GO:0007126)2.57526688
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57408639
191ER-nucleus signaling pathway (GO:0006984)2.56839512
192multicellular organismal reproductive process (GO:0048609)2.54865311
193interferon-gamma secretion (GO:0072643)2.54625046
194protoporphyrinogen IX metabolic process (GO:0046501)10.4809751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.81668151
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.02844035
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.81651758
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.49474320
5* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.40355443
6* GATA1_19941826_ChIP-Seq_K562_Human3.34993867
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.19031893
8KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.89045670
9GATA1_19941827_ChIP-Seq_MEL_Mouse2.70291501
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.67658556
11SCL_19346495_ChIP-Seq_HPC-7_Human2.37921287
12* GATA2_19941826_ChIP-Seq_K562_Human2.20867907
13GATA1_22383799_ChIP-Seq_G1ME_Mouse2.14294676
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10342911
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.04387288
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.98470717
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92761689
18VDR_24787735_ChIP-Seq_THP-1_Human1.87478401
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86196517
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82987299
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82838115
22GATA2_22383799_ChIP-Seq_G1ME_Mouse1.82547740
23* MYB_26560356_Chip-Seq_TH2_Human1.78746961
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78518899
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75782605
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74301448
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70423836
28* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68739137
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68526116
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.68474653
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67811045
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66987115
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64997378
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61141412
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58013702
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57690356
37MYC_22102868_ChIP-Seq_BL_Human1.57301848
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56580856
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54005762
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52628426
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.50827974
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50450491
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49899656
44TCF7_22412390_ChIP-Seq_EML_Mouse1.49680294
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49678366
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.46358307
47* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45348859
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45188520
49E2F7_22180533_ChIP-Seq_HELA_Human1.45013504
50* MYB_26560356_Chip-Seq_TH1_Human1.44455732
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.40149302
52GATA1_19941827_ChIP-Seq_MEL86_Mouse1.37368355
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33231732
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32558493
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32216177
56* MAF_26560356_Chip-Seq_TH1_Human1.32115120
57* UTX_26944678_Chip-Seq_JUKART_Human1.30204193
58SMRT_27268052_Chip-Seq_Bcells_Human1.30144241
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29839249
60* NCOR1_26117541_ChIP-Seq_K562_Human1.27905374
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27421685
62ETS1_22383799_ChIP-Seq_G1ME_Mouse1.27402307
63* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26120381
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25772363
65TP53_16413492_ChIP-PET_HCT116_Human1.23680719
66* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20833732
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.18345211
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.17427708
69GATA6_25053715_ChIP-Seq_YYC3_Human1.17384861
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.10434398
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10395645
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.09717030
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09125282
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06947794
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06323390
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05231672
77FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04831229
78VDR_21846776_ChIP-Seq_THP-1_Human1.04690209
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04557949
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02256509
81SALL4_22934838_ChIP-ChIP_CD34+_Human1.01760410
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01520410
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00635053
84ERG_20517297_ChIP-Seq_VCAP_Human1.00563233
85* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00382935
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99998342
87GATA3_26560356_Chip-Seq_TH1_Human0.98941987
88* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98889503
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98503518
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98242182
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97384254
92AR_21572438_ChIP-Seq_LNCaP_Human0.95761641
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.95488247
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.95399022
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.95384066
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.95323777
97ER_23166858_ChIP-Seq_MCF-7_Human0.94650769
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93569057
99SPI1_23547873_ChIP-Seq_NB4_Human0.93378052
100VDR_24763502_ChIP-Seq_THP-1_Human0.92804318
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92404062
102PU_27001747_Chip-Seq_BMDM_Mouse0.92394631
103SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92226575
104* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91601302
105GATA3_26560356_Chip-Seq_TH2_Human0.90912499
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90860010
107* MAF_26560356_Chip-Seq_TH2_Human0.90188339
108* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90028803
109LXR_22158963_ChIP-Seq_LIVER_Mouse0.89729905
110TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89518005
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.89495521
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88646028
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87948973
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87929615
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87828450
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.87573511
117OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86193768
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86049256
119* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85553125
120* RUNX_20019798_ChIP-Seq_JUKART_Human0.85305325
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.85141041
122* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84510180
123ZNF263_19887448_ChIP-Seq_K562_Human0.84401582
124SPI1_23127762_ChIP-Seq_K562_Human0.83644982
125* TFEB_21752829_ChIP-Seq_HELA_Human0.82753980
126STAT1_17558387_ChIP-Seq_HELA_Human0.82408915
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82217073
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81745103
129FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81650170
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81546090
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.81449449
132* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81256061
133KDM5A_27292631_Chip-Seq_BREAST_Human0.81009659
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80908756
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80657079
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80225142
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78641407
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78465710
139TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78269806
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77973039
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76575622
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76545059
143TP63_23658742_ChIP-Seq_EP156T_Human0.76505025
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75548245
145STAT3_23295773_ChIP-Seq_U87_Human0.75270121
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74584668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.98877207
2MP0000569_abnormal_digit_pigmentation5.35191483
3MP0005410_abnormal_fertilization5.12914059
4MP0004147_increased_porphyrin_level4.19001306
5MP0005083_abnormal_biliary_tract2.96324741
6MP0003724_increased_susceptibility_to2.78806340
7MP0005451_abnormal_body_composition2.62918921
8MP0008877_abnormal_DNA_methylation2.62114740
9MP0001929_abnormal_gametogenesis2.61599979
10MP0004381_abnormal_hair_follicle2.60185067
11MP0005310_abnormal_salivary_gland2.44977836
12MP0000015_abnormal_ear_pigmentation2.37076301
13MP0003300_gastrointestinal_ulcer2.36458982
14MP0008057_abnormal_DNA_replication2.27627996
15MP0004264_abnormal_extraembryonic_tissu2.08957825
16MP0003698_abnormal_male_reproductive2.02642046
17MP0005174_abnormal_tail_pigmentation2.02612717
18MP0005075_abnormal_melanosome_morpholog1.99574623
19MP0004883_abnormal_blood_vessel1.93836688
20MP0001835_abnormal_antigen_presentation1.87540281
21MP0005058_abnormal_lysosome_morphology1.77971853
22MP0003221_abnormal_cardiomyocyte_apopto1.75190922
23MP0005464_abnormal_platelet_physiology1.74101818
24MP0005636_abnormal_mineral_homeostasis1.72289703
25MP0003111_abnormal_nucleus_morphology1.70252279
26MP0002332_abnormal_exercise_endurance1.68407713
27MP0003693_abnormal_embryo_hatching1.59047202
28MP0001666_abnormal_nutrient_absorption1.57512053
29MP0002398_abnormal_bone_marrow1.57237668
30MP0002396_abnormal_hematopoietic_system1.57013942
31MP0002693_abnormal_pancreas_physiology1.54972938
32MP0005671_abnormal_response_to1.54237303
33MP0002210_abnormal_sex_determination1.53379612
34MP0008260_abnormal_autophagy1.52668424
35MP0002877_abnormal_melanocyte_morpholog1.52200184
36MP0000685_abnormal_immune_system1.51752892
37MP0009785_altered_susceptibility_to1.50614922
38MP0002161_abnormal_fertility/fecundity1.47119276
39MP0004484_altered_response_of1.45296282
40MP0003303_peritoneal_inflammation1.43444835
41MP0000653_abnormal_sex_gland1.43426729
42MP0000490_abnormal_crypts_of1.42449278
43MP0005387_immune_system_phenotype1.38841506
44MP0001790_abnormal_immune_system1.38841506
45MP0003866_abnormal_defecation1.36329445
46MP0003718_maternal_effect1.35541075
47MP0001800_abnormal_humoral_immune1.33429934
48MP0002166_altered_tumor_susceptibility1.33344816
49MP0001145_abnormal_male_reproductive1.33126125
50MP0001873_stomach_inflammation1.32262855
51MP0002009_preneoplasia1.30699255
52MP0000689_abnormal_spleen_morphology1.30278056
53MP0005220_abnormal_exocrine_pancreas1.29623129
54MP0003828_pulmonary_edema1.29381603
55MP0010307_abnormal_tumor_latency1.29326517
56MP0004510_myositis1.28787621
57MP0001545_abnormal_hematopoietic_system1.28114435
58MP0005397_hematopoietic_system_phenotyp1.28114435
59MP0000465_gastrointestinal_hemorrhage1.26317437
60MP0003077_abnormal_cell_cycle1.25396329
61MP0002452_abnormal_antigen_presenting1.24831202
62MP0005000_abnormal_immune_tolerance1.24321192
63MP0002405_respiratory_system_inflammati1.20623597
64MP0002723_abnormal_immune_serum1.20393348
65MP0002420_abnormal_adaptive_immunity1.19667911
66MP0005164_abnormal_response_to1.19460247
67MP0003763_abnormal_thymus_physiology1.19359007
68MP0001819_abnormal_immune_cell1.18620239
69MP0002429_abnormal_blood_cell1.18487879
70MP0002722_abnormal_immune_system1.18487343
71MP0005670_abnormal_white_adipose1.18443563
72MP0004947_skin_inflammation1.18249574
73MP0003787_abnormal_imprinting1.17431465
74MP0009333_abnormal_splenocyte_physiolog1.14010838
75MP0003183_abnormal_peptide_metabolism1.13297874
76MP0001765_abnormal_ion_homeostasis1.12028361
77MP0000716_abnormal_immune_system1.10166122
78MP0006054_spinal_hemorrhage1.08901935
79MP0003699_abnormal_female_reproductive1.08006271
80MP0010094_abnormal_chromosome_stability1.06842691
81MP0003436_decreased_susceptibility_to1.06407232
82MP0003329_amyloid_beta_deposits1.06221551
83MP0003121_genomic_imprinting1.05581686
84MP0002419_abnormal_innate_immunity1.05438127
85MP0003091_abnormal_cell_migration1.05208024
86MP0001845_abnormal_inflammatory_respons1.04187419
87MP0002006_tumorigenesis1.03795408
88MP0005025_abnormal_response_to1.02109503
89MP0001944_abnormal_pancreas_morphology1.00841180
90MP0006082_CNS_inflammation0.99524523
91MP0003690_abnormal_glial_cell0.99291679
92MP0002138_abnormal_hepatobiliary_system0.98341893
93MP0000858_altered_metastatic_potential0.97023026
94MP0005076_abnormal_cell_differentiation0.94780549
95MP0000609_abnormal_liver_physiology0.94765593
96MP0004130_abnormal_muscle_cell0.94094098
97MP0001851_eye_inflammation0.93119014
98MP0000604_amyloidosis0.91601557
99MP0002019_abnormal_tumor_incidence0.91558890
100MP0000371_diluted_coat_color0.90322710
101MP0004808_abnormal_hematopoietic_stem0.88898346
102MP0003868_abnormal_feces_composition0.88810615
103MP0005365_abnormal_bile_salt0.88075915
104MP0000703_abnormal_thymus_morphology0.86669784
105MP0001119_abnormal_female_reproductive0.86346653
106MP0003172_abnormal_lysosome_physiology0.84974208
107MP0005266_abnormal_metabolism0.84816593
108MP0003646_muscle_fatigue0.84536907
109MP0010155_abnormal_intestine_physiology0.84164936
110MP0005408_hypopigmentation0.83685794
111MP0002132_abnormal_respiratory_system0.83359822
112MP0009643_abnormal_urine_homeostasis0.82661588
113MP0005376_homeostasis/metabolism_phenot0.82428278
114MP0008469_abnormal_protein_level0.82030086
115MP0009764_decreased_sensitivity_to0.79888673
116MP0003632_abnormal_nervous_system0.79710129
117MP0002928_abnormal_bile_duct0.78562546
118MP0003191_abnormal_cellular_cholesterol0.76229526
119MP0002139_abnormal_hepatobiliary_system0.75969921
120MP0005621_abnormal_cell_physiology0.75597473
121MP0005395_other_phenotype0.75278683
122MP0000427_abnormal_hair_cycle0.75087054
123MP0008995_early_reproductive_senescence0.74593254
124MP0000313_abnormal_cell_death0.74438266
125MP0004185_abnormal_adipocyte_glucose0.74111755
126MP0001533_abnormal_skeleton_physiology0.71235997
127MP0003186_abnormal_redox_activity0.70978841
128MP0009765_abnormal_xenobiotic_induced0.70299834
129MP0001919_abnormal_reproductive_system0.69920617
130MP0003453_abnormal_keratinocyte_physiol0.68757962
131MP0000350_abnormal_cell_proliferation0.68486406
132MP0002148_abnormal_hypersensitivity_rea0.68406366
133MP0000598_abnormal_liver_morphology0.68401096
134MP0008874_decreased_physiological_sensi0.68332677
135MP0009763_increased_sensitivity_to0.67191011
136MP0001958_emphysema0.65780170
137MP0001663_abnormal_digestive_system0.63273154
138MP0002136_abnormal_kidney_physiology0.61101929
139MP0002095_abnormal_skin_pigmentation0.59554966
140MP0000249_abnormal_blood_vessel0.56740439
141MP0002971_abnormal_brown_adipose0.55891194
142MP0002998_abnormal_bone_remodeling0.55652650
143MP0005384_cellular_phenotype0.55063272
144MP0003045_fibrosis0.54606654
145MP0005409_darkened_coat_color0.52164793
146MP0001853_heart_inflammation0.50969438

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.13816161
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.57493493
3Hypochromic microcytic anemia (HP:0004840)6.56053814
4Acanthocytosis (HP:0001927)6.21312011
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.82055528
6Male infertility (HP:0003251)5.03824557
7Infertility (HP:0000789)4.81444629
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.66497142
9Absent/shortened dynein arms (HP:0200106)4.66497142
10Reticulocytosis (HP:0001923)4.63677342
11Nasal polyposis (HP:0100582)4.60753080
12Cholelithiasis (HP:0001081)4.45667808
13Gastrointestinal infarctions (HP:0005244)4.33449724
14Abnormal gallbladder morphology (HP:0012437)4.06706231
15Slow saccadic eye movements (HP:0000514)4.02069980
16Gingival bleeding (HP:0000225)3.95352062
17Abnormality of the nasal mucosa (HP:0000433)3.84586174
18Chronic bronchitis (HP:0004469)3.82926955
19Retrobulbar optic neuritis (HP:0100654)3.77519399
20Optic neuritis (HP:0100653)3.77519399
21Postural instability (HP:0002172)3.75796676
22Myositis (HP:0100614)3.60262135
23Tetraparesis (HP:0002273)3.55674971
24Abnormal respiratory motile cilium physiology (HP:0012261)3.55118494
25Orchitis (HP:0100796)3.47965808
26Recurrent skin infections (HP:0001581)3.46350675
27Visual hallucinations (HP:0002367)3.46060681
28Gingivitis (HP:0000230)3.38219080
29Bronchiectasis (HP:0002110)3.37517021
30Microcytic anemia (HP:0001935)3.36664695
31Hypochromic anemia (HP:0001931)3.31854401
32Bronchitis (HP:0012387)3.29306852
33Abnormality of T cells (HP:0002843)3.25984607
34Recurrent sinusitis (HP:0011108)3.25376520
35Heterotopia (HP:0002282)3.24685940
36Leukocytosis (HP:0001974)3.15753682
37Spontaneous hematomas (HP:0007420)3.14992274
38Peritonitis (HP:0002586)3.14259383
39Rhinitis (HP:0012384)3.10895619
40Stomatitis (HP:0010280)3.09777582
41Recurrent cutaneous fungal infections (HP:0011370)3.06545784
42Chronic mucocutaneous candidiasis (HP:0002728)3.06545784
43Paralysis (HP:0003470)3.03903881
44Hyperbilirubinemia (HP:0002904)3.00182136
45Abnormal gallbladder physiology (HP:0012438)2.99242919
46Cholecystitis (HP:0001082)2.99242919
47Osteomalacia (HP:0002749)2.98926716
48Subacute progressive viral hepatitis (HP:0006572)2.96206496
49Conjunctival telangiectasia (HP:0000524)2.95127442
50Elevated erythrocyte sedimentation rate (HP:0003565)2.94837058
51Recurrent bronchitis (HP:0002837)2.93560116
52Abnormality of the fingertips (HP:0001211)2.90401598
53Pustule (HP:0200039)2.90161863
54Periodontitis (HP:0000704)2.89781459
55Arterial thrombosis (HP:0004420)2.89646028
56Cortical dysplasia (HP:0002539)2.83436940
57Abnormality of macrophages (HP:0004311)2.83324715
58Abnormal respiratory epithelium morphology (HP:0012253)2.81662287
59Abnormal respiratory motile cilium morphology (HP:0005938)2.81662287
60Diaphragmatic weakness (HP:0009113)2.77702728
61Abnormality of the gallbladder (HP:0005264)2.75061958
62Orthostatic hypotension (HP:0001278)2.74992445
63Keratoconjunctivitis sicca (HP:0001097)2.74379663
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73708737
65Vasculitis (HP:0002633)2.73345882
66Chest pain (HP:0100749)2.72777609
67Polycythemia (HP:0001901)2.71878638
68Resting tremor (HP:0002322)2.67666702
69Hypoplasia of the thymus (HP:0000778)2.65629860
70Eosinophilia (HP:0001880)2.61709665
71Abnormality of reticulocytes (HP:0004312)2.61686958
72Petechiae (HP:0000967)2.60331536
73Colitis (HP:0002583)2.58608562
74Acute hepatic failure (HP:0006554)2.58389522
75Keratoconjunctivitis (HP:0001096)2.58059917
76Cutaneous photosensitivity (HP:0000992)2.55358761
77Meningitis (HP:0001287)2.53114833
78Recurrent otitis media (HP:0000403)2.49642709
79Global brain atrophy (HP:0002283)2.45759081
80Encephalitis (HP:0002383)2.42269350
81Autoimmune hemolytic anemia (HP:0001890)2.39541643
82Abnormality of eosinophils (HP:0001879)2.38026942
83Viral hepatitis (HP:0006562)2.37285662
84Hyperkalemia (HP:0002153)2.35561564
85IgA deficiency (HP:0002720)2.34538188
86Glucose intolerance (HP:0000833)2.29193567
87Granulocytopenia (HP:0001913)2.28120996
88Cerebral inclusion bodies (HP:0100314)2.27119687
89Insulin-resistant diabetes mellitus (HP:0000831)2.25330859
90Hemoptysis (HP:0002105)2.24363980
91Abnormal ciliary motility (HP:0012262)2.23669474
92Mediastinal lymphadenopathy (HP:0100721)2.23605556
93Recurrent abscess formation (HP:0002722)2.23157702
94Abnormal spermatogenesis (HP:0008669)2.22103311
95Urticaria (HP:0001025)2.21220276
96Inflammation of the large intestine (HP:0002037)2.20692341
97Prominent nose (HP:0000448)2.20353616
98Thyroiditis (HP:0100646)2.19844699
99Recurrent viral infections (HP:0004429)2.18103173
100Hemorrhage of the eye (HP:0011885)2.15721125
101Chronic obstructive pulmonary disease (HP:0006510)2.11664150
102Obstructive lung disease (HP:0006536)2.11664150
103Abnormal platelet volume (HP:0011876)2.10322854
104Autoimmune thrombocytopenia (HP:0001973)2.09236442
105Aortic aneurysm (HP:0004942)2.06027878
106Gastrointestinal inflammation (HP:0004386)2.05649391
107Verrucae (HP:0200043)2.03966386
108Papilloma (HP:0012740)2.03966386
109Increased mean platelet volume (HP:0011877)2.02588897
110Truncal obesity (HP:0001956)2.01200540
111Recurrent bacterial skin infections (HP:0005406)2.00842039
112Cellulitis (HP:0100658)2.00759898
113Zonular cataract (HP:0010920)1.99983559
114Neoplasm of the tracheobronchial system (HP:0100552)1.98995211
115Anorexia (HP:0002039)1.98727982
116Abnormal platelet function (HP:0011869)1.97276596
117Impaired platelet aggregation (HP:0003540)1.97276596
118Insomnia (HP:0100785)1.96995274
119Thyroid carcinoma (HP:0002890)1.95729597
120Exocrine pancreatic insufficiency (HP:0001738)1.94363824
121Dysautonomia (HP:0002459)1.93295213
122Increased cerebral lipofuscin (HP:0011813)1.93234009
123Stomach cancer (HP:0012126)1.92537838
124Abnormal glucose tolerance (HP:0001952)1.91768829
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.90848828
126Papillary thyroid carcinoma (HP:0002895)1.90771012
127Ocular albinism (HP:0001107)1.88193503
128Hematochezia (HP:0002573)1.87458077
129Lymphopenia (HP:0001888)1.86405013
130IgG deficiency (HP:0004315)1.85356984
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.84604318
132IgM deficiency (HP:0002850)1.82094911
133Bilateral sensorineural hearing impairment (HP:0008619)1.81058954
134Eczematoid dermatitis (HP:0000976)1.80084992
135Impulsivity (HP:0100710)1.75152435
136Retinal atrophy (HP:0001105)1.75020560
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.73075824
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72415835
139Premature ovarian failure (HP:0008209)1.71766284
140Dysostosis multiplex (HP:0000943)1.70725671
141Myocardial infarction (HP:0001658)1.68316720
142Recurrent gram-negative bacterial infections (HP:0005420)1.67986641
143Azoospermia (HP:0000027)1.65203431
144Generalized hyperpigmentation (HP:0007440)1.64154120
145Vacuolated lymphocytes (HP:0001922)1.61681424
146T lymphocytopenia (HP:0005403)1.59354802
147Recurrent fungal infections (HP:0002841)1.55005033
148Abnormality of small intestinal villus morphology (HP:0011472)1.54971981
149Villous atrophy (HP:0011473)1.54971981
150Abnormality of T cell physiology (HP:0011840)1.53840884
151Nuclear cataract (HP:0100018)1.53816756
152Increased CSF protein (HP:0002922)1.52660651
153Agammaglobulinemia (HP:0004432)1.51089120
154Prolonged bleeding time (HP:0003010)1.50810304
155Fatigue (HP:0012378)1.47886284
156Abnormality of T cell number (HP:0011839)1.47539317
157Status epilepticus (HP:0002133)1.47018223
158Epistaxis (HP:0000421)1.46639599
159Onycholysis (HP:0001806)1.45812803
160Abnormality of transition element cation homeostasis (HP:0011030)1.44206181
161Pulmonary infiltrates (HP:0002113)1.44118366
162Tubulointerstitial fibrosis (HP:0005576)1.43861472
163Hepatocellular carcinoma (HP:0001402)1.43188582
164Spondylolisthesis (HP:0003302)1.42909283
165Osteomyelitis (HP:0002754)1.42675599
166Nephronophthisis (HP:0000090)1.42634071
167Ileus (HP:0002595)1.42483450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.15476960
2EIF2AK14.15241295
3EEF2K3.04687401
4PRKD32.72020378
5BLK2.65727167
6MAP2K32.55003275
7FGR2.52722056
8STK102.41185741
9PDK32.40247810
10PDK42.40247810
11SGK22.24809024
12ERN12.20859209
13CDK122.17951614
14WNK12.04296478
15TESK12.03343754
16PDK22.03053853
17STK42.00052600
18PIK3CG1.99690454
19GRK51.98022364
20CSK1.95548150
21MAP4K11.92970722
22STK31.92495293
23IRAK31.84716387
24PLK21.76701670
25FGFR31.73385530
26LATS11.69674069
27FES1.61553154
28TGFBR21.60545327
29PIM11.60482846
30MAP3K131.56774375
31TRIB31.55450812
32TYK21.52437976
33MAP3K31.47385703
34MAPKAPK31.44666198
35IKBKE1.42543726
36NEK21.40738220
37SGK4941.38885436
38SGK2231.38885436
39DYRK1B1.37267331
40BTK1.36820325
41ICK1.36603221
42TBK11.35010715
43ZAP701.30163561
44JAK31.28746492
45TLK11.26530616
46MAP3K11.25743676
47NLK1.23215456
48MOS1.19670535
49CAMKK21.18613042
50ERBB21.18520513
51MELK1.17453063
52MARK21.17079124
53HCK1.16758916
54DYRK31.15911458
55TTK1.15910315
56MARK31.15127659
57CDK91.14702326
58TEC1.13056509
59JAK21.10934472
60CDK61.08300857
61MAP3K101.08035452
62CHEK21.04557781
63MAP3K61.02861908
64TAOK11.02739213
65SYK1.01353231
66CHUK1.01219489
67YES11.00499070
68JAK10.98084964
69PRPF4B0.97046803
70MAP3K80.96659139
71PRKAA10.96478526
72IKBKB0.95046195
73PDK10.92780163
74DYRK1A0.91908909
75TAOK20.90361895
76IRAK40.89611408
77MAP3K110.88545987
78TRPM70.82995436
79IRAK20.80182751
80KSR10.80007813
81KSR20.79664820
82ACVR1B0.79358426
83NEK60.78945761
84SGK10.78914084
85SCYL20.76846405
86BMPR20.72618459
87AKT30.71893931
88EPHB10.71474297
89STK110.71450224
90MAP3K50.69994100
91ZAK0.69563906
92HIPK20.67528313
93NEK90.66675107
94MATK0.66209269
95RAF10.63650676
96WNK40.62946862
97MAPK150.62644282
98FRK0.61261610
99MAP3K20.60534204
100EGFR0.60390395
101CDK40.60256958
102PDPK10.60146370
103PKN20.58937681
104GRK60.58489251
105ITK0.58479909
106MAP3K70.58113626
107INSRR0.57902039
108RIPK40.57576711
109MAPK110.56662100
110PAK30.56454477
111CAMK1D0.54895412
112PTK2B0.53859560
113IRAK10.53649990
114CSF1R0.53043639
115MAP2K20.52952593
116STK380.52829756
117PRKAA20.52414050
118RPS6KA50.52308661
119AURKB0.52153532
120PRKD20.52145754
121MAP3K140.52072500
122MTOR0.50601831
123CAMK40.50412522
124PLK40.49504197
125RET0.47950029
126SGK30.47727665
127CDC70.47461783
128BRAF0.46945543
129TXK0.45864370
130CAMK1G0.44978257
131CHEK10.44749083
132BRD40.43961316
133RIPK10.43441175
134TNK20.43439932
135PRKCQ0.43371152
136STK240.43019081
137LCK0.42370456
138ATM0.41887427
139ADRBK10.41727959
140PTK60.41246729
141PASK0.40778206
142BRSK20.40464521
143BRSK10.40396791
144LRRK20.39132310
145LYN0.38945428
146FGFR40.38882673
147PDGFRB0.38148643
148BCKDK0.37871385
149MST40.36096980
150CAMKK10.34842333
151FGFR20.33859051

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.39989059
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.76787843
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.04145188
4Systemic lupus erythematosus_Homo sapiens_hsa053222.72043856
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.51622607
6Other glycan degradation_Homo sapiens_hsa005112.12333420
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11949584
8Pancreatic secretion_Homo sapiens_hsa049721.85829827
9Protein export_Homo sapiens_hsa030601.69450680
10Antigen processing and presentation_Homo sapiens_hsa046121.63547059
11ABC transporters_Homo sapiens_hsa020101.58087315
12Chemokine signaling pathway_Homo sapiens_hsa040621.55513257
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.54635258
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52873258
15Dorso-ventral axis formation_Homo sapiens_hsa043201.52240716
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45076679
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44323015
18Endometrial cancer_Homo sapiens_hsa052131.39958822
19Measles_Homo sapiens_hsa051621.38529609
20Viral carcinogenesis_Homo sapiens_hsa052031.37629245
21Pancreatic cancer_Homo sapiens_hsa052121.31905074
22Hematopoietic cell lineage_Homo sapiens_hsa046401.30962234
23Lysosome_Homo sapiens_hsa041421.30326432
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29703826
25B cell receptor signaling pathway_Homo sapiens_hsa046621.27470323
26Selenocompound metabolism_Homo sapiens_hsa004501.27267884
27Graft-versus-host disease_Homo sapiens_hsa053321.26071525
28Fat digestion and absorption_Homo sapiens_hsa049751.24397380
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.22638304
30Osteoclast differentiation_Homo sapiens_hsa043801.21896864
31Influenza A_Homo sapiens_hsa051641.20491029
32Autoimmune thyroid disease_Homo sapiens_hsa053201.19333421
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18947762
34Allograft rejection_Homo sapiens_hsa053301.18170226
35Linoleic acid metabolism_Homo sapiens_hsa005911.17869803
36Apoptosis_Homo sapiens_hsa042101.17424953
37Glycerolipid metabolism_Homo sapiens_hsa005611.16556656
38Renal cell carcinoma_Homo sapiens_hsa052111.16064078
39Malaria_Homo sapiens_hsa051441.09148566
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.08470384
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.06933316
42Leishmaniasis_Homo sapiens_hsa051401.06669509
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.06623418
44Toxoplasmosis_Homo sapiens_hsa051451.05577317
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05550686
46Alcoholism_Homo sapiens_hsa050341.05357275
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05212062
48Type I diabetes mellitus_Homo sapiens_hsa049401.03747775
49Cell cycle_Homo sapiens_hsa041101.03365523
50Herpes simplex infection_Homo sapiens_hsa051681.02760218
51Basal transcription factors_Homo sapiens_hsa030221.02351096
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.00470722
53N-Glycan biosynthesis_Homo sapiens_hsa005100.99658661
54Prolactin signaling pathway_Homo sapiens_hsa049170.99137896
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95614193
56Protein digestion and absorption_Homo sapiens_hsa049740.95446944
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94118168
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93990546
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93476634
60Regulation of autophagy_Homo sapiens_hsa041400.92334317
61Hepatitis B_Homo sapiens_hsa051610.91099488
62p53 signaling pathway_Homo sapiens_hsa041150.90957569
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89701717
64Inositol phosphate metabolism_Homo sapiens_hsa005620.89313452
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.89122866
66Prostate cancer_Homo sapiens_hsa052150.88530936
67mTOR signaling pathway_Homo sapiens_hsa041500.88500343
68Legionellosis_Homo sapiens_hsa051340.85317053
69Glioma_Homo sapiens_hsa052140.84565803
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84484091
71Primary immunodeficiency_Homo sapiens_hsa053400.83725535
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83218737
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81989279
74Fanconi anemia pathway_Homo sapiens_hsa034600.79933598
75Collecting duct acid secretion_Homo sapiens_hsa049660.79018258
76Staphylococcus aureus infection_Homo sapiens_hsa051500.78444489
77Insulin resistance_Homo sapiens_hsa049310.77404900
78Non-small cell lung cancer_Homo sapiens_hsa052230.76482116
79Long-term potentiation_Homo sapiens_hsa047200.76079016
80Small cell lung cancer_Homo sapiens_hsa052220.75486908
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74903843
82T cell receptor signaling pathway_Homo sapiens_hsa046600.73375960
83FoxO signaling pathway_Homo sapiens_hsa040680.73066696
84HIF-1 signaling pathway_Homo sapiens_hsa040660.71451106
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.71288803
86ErbB signaling pathway_Homo sapiens_hsa040120.71175365
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70534512
88Choline metabolism in cancer_Homo sapiens_hsa052310.69645216
89Thyroid cancer_Homo sapiens_hsa052160.68728556
90Notch signaling pathway_Homo sapiens_hsa043300.67567209
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67417532
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67165484
93Glucagon signaling pathway_Homo sapiens_hsa049220.64816534
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64184128
95Fatty acid biosynthesis_Homo sapiens_hsa000610.64075783
96AMPK signaling pathway_Homo sapiens_hsa041520.63970773
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63812919
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63166981
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62770719
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62576767
101Phagosome_Homo sapiens_hsa041450.62299590
102Tuberculosis_Homo sapiens_hsa051520.61767651
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61681224
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.60370848
105GnRH signaling pathway_Homo sapiens_hsa049120.59809616
106Circadian rhythm_Homo sapiens_hsa047100.59362325
107Acute myeloid leukemia_Homo sapiens_hsa052210.58769142
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58308301
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56344035
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54998308
111Mineral absorption_Homo sapiens_hsa049780.54471610
112Ether lipid metabolism_Homo sapiens_hsa005650.54395081
113MAPK signaling pathway_Homo sapiens_hsa040100.53986189
114MicroRNAs in cancer_Homo sapiens_hsa052060.53807700
115Endocytosis_Homo sapiens_hsa041440.51733469
116Hepatitis C_Homo sapiens_hsa051600.50723568
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.50723377
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49983774
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48685549
120TNF signaling pathway_Homo sapiens_hsa046680.48545908
121Type II diabetes mellitus_Homo sapiens_hsa049300.48150462
122Viral myocarditis_Homo sapiens_hsa054160.47573406
123Oocyte meiosis_Homo sapiens_hsa041140.47266047
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47224490
125Ovarian steroidogenesis_Homo sapiens_hsa049130.46631582
126VEGF signaling pathway_Homo sapiens_hsa043700.44967482
127African trypanosomiasis_Homo sapiens_hsa051430.44850337
128Epstein-Barr virus infection_Homo sapiens_hsa051690.44558751
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44497694
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43566030
131Colorectal cancer_Homo sapiens_hsa052100.43119679
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42952760
133mRNA surveillance pathway_Homo sapiens_hsa030150.42790844
134HTLV-I infection_Homo sapiens_hsa051660.42293712
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41909723
136Renin-angiotensin system_Homo sapiens_hsa046140.41742081
137Platelet activation_Homo sapiens_hsa046110.40869130
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40782799
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40029141

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