Rank | Gene Set | Z-score |
---|---|---|
1 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 8.69455711 |
2 | porphyrin-containing compound biosynthetic process (GO:0006779) | 7.21979570 |
3 | tetrapyrrole biosynthetic process (GO:0033014) | 6.33219096 |
4 | heme biosynthetic process (GO:0006783) | 6.28380211 |
5 | multicellular organism reproduction (GO:0032504) | 6.26422125 |
6 | piRNA metabolic process (GO:0034587) | 5.92806511 |
7 | fusion of sperm to egg plasma membrane (GO:0007342) | 5.91761435 |
8 | sperm motility (GO:0030317) | 5.72268404 |
9 | porphyrin-containing compound metabolic process (GO:0006778) | 5.68868448 |
10 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.53740326 |
11 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.34773604 |
12 | negative regulation of cell killing (GO:0031342) | 5.34773604 |
13 | reproduction (GO:0000003) | 5.33289218 |
14 | microglial cell activation (GO:0001774) | 5.31984427 |
15 | sperm-egg recognition (GO:0035036) | 5.29178229 |
16 | erythrocyte maturation (GO:0043249) | 5.25890276 |
17 | cell wall macromolecule metabolic process (GO:0044036) | 5.18085919 |
18 | cell wall macromolecule catabolic process (GO:0016998) | 5.18085919 |
19 | acrosome assembly (GO:0001675) | 5.13539384 |
20 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.07979928 |
21 | binding of sperm to zona pellucida (GO:0007339) | 4.97003017 |
22 | heme metabolic process (GO:0042168) | 4.83011586 |
23 | cell-cell recognition (GO:0009988) | 4.82069149 |
24 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.81131617 |
25 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 4.78924044 |
26 | regulation of gamma-delta T cell activation (GO:0046643) | 4.71436507 |
27 | hemoglobin metabolic process (GO:0020027) | 4.57876000 |
28 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 4.56197895 |
29 | acrosome reaction (GO:0007340) | 4.53730057 |
30 | response to methylmercury (GO:0051597) | 4.50707189 |
31 | spermatid development (GO:0007286) | 4.46758392 |
32 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.40699090 |
33 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.40257411 |
34 | positive T cell selection (GO:0043368) | 4.40146462 |
35 | histone H3-K36 demethylation (GO:0070544) | 4.36640922 |
36 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 4.33072620 |
37 | negative T cell selection (GO:0043383) | 4.32716144 |
38 | motile cilium assembly (GO:0044458) | 4.27200913 |
39 | erythrocyte development (GO:0048821) | 4.26095935 |
40 | negative regulation of inclusion body assembly (GO:0090084) | 4.20765204 |
41 | plasma membrane fusion (GO:0045026) | 4.20474511 |
42 | positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110 | 4.16868883 |
43 | mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) | 4.16868883 |
44 | negative thymic T cell selection (GO:0045060) | 4.12530653 |
45 | detection of molecule of bacterial origin (GO:0032490) | 4.12499396 |
46 | positive thymic T cell selection (GO:0045059) | 4.11759882 |
47 | positive regulation of granulocyte differentiation (GO:0030854) | 4.07811439 |
48 | regulation of beta-amyloid formation (GO:1902003) | 3.95404757 |
49 | tetrapyrrole metabolic process (GO:0033013) | 3.91112830 |
50 | male meiosis (GO:0007140) | 3.89882886 |
51 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.87013854 |
52 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.87013854 |
53 | modulation by symbiont of host immune response (GO:0052553) | 3.87013854 |
54 | positive regulation by symbiont of host defense response (GO:0052509) | 3.87013854 |
55 | modulation by symbiont of host defense response (GO:0052031) | 3.87013854 |
56 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.87013854 |
57 | macrophage activation (GO:0042116) | 3.84742300 |
58 | single fertilization (GO:0007338) | 3.84473181 |
59 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.80221356 |
60 | positive regulation of receptor recycling (GO:0001921) | 3.78580512 |
61 | histone mRNA catabolic process (GO:0071044) | 3.76197657 |
62 | cellular extravasation (GO:0045123) | 3.76177785 |
63 | negative regulation of T cell mediated immunity (GO:0002710) | 3.71365768 |
64 | regulation of necroptotic process (GO:0060544) | 3.70223219 |
65 | fertilization (GO:0009566) | 3.69157991 |
66 | B cell receptor signaling pathway (GO:0050853) | 3.65707501 |
67 | neutrophil mediated immunity (GO:0002446) | 3.65014956 |
68 | activated T cell proliferation (GO:0050798) | 3.64507587 |
69 | positive regulation of insulin receptor signaling pathway (GO:0046628) | 3.63823717 |
70 | negative regulation of B cell proliferation (GO:0030889) | 3.62690273 |
71 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.60464200 |
72 | axonemal dynein complex assembly (GO:0070286) | 3.59596844 |
73 | myeloid leukocyte mediated immunity (GO:0002444) | 3.59438749 |
74 | macrophage activation involved in immune response (GO:0002281) | 3.57640373 |
75 | microtubule depolymerization (GO:0007019) | 3.55099966 |
76 | response to insecticide (GO:0017085) | 3.54596720 |
77 | chromosome condensation (GO:0030261) | 3.51358590 |
78 | regulation of acrosome reaction (GO:0060046) | 3.49357202 |
79 | protein targeting to Golgi (GO:0000042) | 3.48639284 |
80 | protein K48-linked deubiquitination (GO:0071108) | 3.47080593 |
81 | DNA methylation involved in gamete generation (GO:0043046) | 3.45917468 |
82 | regulation of female gonad development (GO:2000194) | 3.45530109 |
83 | establishment of protein localization to Golgi (GO:0072600) | 3.44768082 |
84 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.44346354 |
85 | gene silencing by RNA (GO:0031047) | 3.42974938 |
86 | epithelial cilium movement (GO:0003351) | 3.42256403 |
87 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.41835453 |
88 | synaptonemal complex organization (GO:0070193) | 3.41833375 |
89 | COPI coating of Golgi vesicle (GO:0048205) | 3.36880901 |
90 | Golgi transport vesicle coating (GO:0048200) | 3.36880901 |
91 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 3.36152269 |
92 | synaptonemal complex assembly (GO:0007130) | 3.35725554 |
93 | L-alpha-amino acid transmembrane transport (GO:1902475) | 3.34984514 |
94 | T cell migration (GO:0072678) | 3.32951947 |
95 | regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640) | 3.30567013 |
96 | histone H3-K4 trimethylation (GO:0080182) | 3.25302422 |
97 | spermatogenesis (GO:0007283) | 3.25294534 |
98 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.24733037 |
99 | citrulline biosynthetic process (GO:0019240) | 3.24231082 |
100 | male gamete generation (GO:0048232) | 3.23971284 |
101 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 3.21965994 |
102 | positive regulation of response to oxidative stress (GO:1902884) | 3.21501801 |
103 | positive regulation of cellular response to oxidative stress (GO:1900409) | 3.21501801 |
104 | T cell selection (GO:0045058) | 3.19092732 |
105 | meiotic cell cycle (GO:0051321) | 3.16612766 |
106 | detection of external biotic stimulus (GO:0098581) | 3.14234748 |
107 | negative regulation of B cell mediated immunity (GO:0002713) | 3.13262584 |
108 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 3.13262584 |
109 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.12871000 |
110 | gamete generation (GO:0007276) | 3.12533211 |
111 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 3.11202453 |
112 | receptor recycling (GO:0001881) | 3.10866516 |
113 | DNA packaging (GO:0006323) | 3.10582598 |
114 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.08942426 |
115 | positive regulation of erythrocyte differentiation (GO:0045648) | 3.08261892 |
116 | regulation of B cell differentiation (GO:0045577) | 3.08189578 |
117 | protein K63-linked deubiquitination (GO:0070536) | 3.08064257 |
118 | ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) | 3.07152989 |
119 | response to interleukin-15 (GO:0070672) | 3.04422763 |
120 | erythrocyte differentiation (GO:0030218) | 3.03710179 |
121 | protein localization to chromosome, centromeric region (GO:0071459) | 3.03349915 |
122 | cellular response to ethanol (GO:0071361) | 3.03181634 |
123 | regulation of regulatory T cell differentiation (GO:0045589) | 3.02619111 |
124 | positive regulation of nuclease activity (GO:0032075) | 3.01652002 |
125 | response to arsenic-containing substance (GO:0046685) | 3.00835950 |
126 | negative regulation of adaptive immune response (GO:0002820) | 3.00137204 |
127 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.99771081 |
128 | oocyte maturation (GO:0001556) | 2.99051493 |
129 | negative regulation of interleukin-12 production (GO:0032695) | 2.98027023 |
130 | positive regulation of humoral immune response (GO:0002922) | 2.97759522 |
131 | mitotic sister chromatid cohesion (GO:0007064) | 2.97450377 |
132 | histone H3-K9 demethylation (GO:0033169) | 2.96842211 |
133 | negative regulation of execution phase of apoptosis (GO:1900118) | 2.96749110 |
134 | mitotic chromosome condensation (GO:0007076) | 2.95850648 |
135 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.95793132 |
136 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.95768541 |
137 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.93867033 |
138 | detection of other organism (GO:0098543) | 2.93679999 |
139 | regulation of inositol phosphate biosynthetic process (GO:0010919) | 2.90033612 |
140 | oocyte development (GO:0048599) | 2.90015806 |
141 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 2.88997964 |
142 | positive regulation of B cell differentiation (GO:0045579) | 2.87569743 |
143 | regulation of response to osmotic stress (GO:0047484) | 2.87489357 |
144 | regulation of cellular amide metabolic process (GO:0034248) | 2.86583159 |
145 | positive regulation of mitochondrial membrane permeability (GO:0035794) | 2.86216614 |
146 | regulation of inclusion body assembly (GO:0090083) | 2.85569328 |
147 | myeloid cell development (GO:0061515) | 2.85310305 |
148 | cellular response to unfolded protein (GO:0034620) | 2.84726856 |
149 | thymic T cell selection (GO:0045061) | 2.84588664 |
150 | regulation of platelet aggregation (GO:0090330) | 2.83917940 |
151 | myeloid cell activation involved in immune response (GO:0002275) | 2.83755853 |
152 | endoplasmic reticulum unfolded protein response (GO:0030968) | 2.82444718 |
153 | leukocyte aggregation (GO:0070486) | 2.81623302 |
154 | cellular response to epinephrine stimulus (GO:0071872) | 2.79847098 |
155 | response to host immune response (GO:0052572) | 2.79675661 |
156 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.79675661 |
157 | germ cell development (GO:0007281) | 2.78346855 |
158 | regulation of nuclease activity (GO:0032069) | 2.76930645 |
159 | regulation of cilium movement (GO:0003352) | 2.76400163 |
160 | negative regulation of complement activation (GO:0045916) | 2.75712417 |
161 | respiratory burst (GO:0045730) | 2.75180277 |
162 | regulation of mRNA catabolic process (GO:0061013) | 2.74894696 |
163 | regulation of granulocyte differentiation (GO:0030852) | 2.74755938 |
164 | seminiferous tubule development (GO:0072520) | 2.74442925 |
165 | neutrophil activation involved in immune response (GO:0002283) | 2.74216678 |
166 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.72545854 |
167 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.72545854 |
168 | negative regulation of protein oligomerization (GO:0032460) | 2.72117363 |
169 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.71886285 |
170 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.71886285 |
171 | regulation of cilium assembly (GO:1902017) | 2.71431598 |
172 | protein K11-linked deubiquitination (GO:0035871) | 2.70076105 |
173 | response to lead ion (GO:0010288) | 2.69813730 |
174 | cellular response to topologically incorrect protein (GO:0035967) | 2.69745238 |
175 | gene silencing (GO:0016458) | 2.69532450 |
176 | negative regulation of organelle assembly (GO:1902116) | 2.68716622 |
177 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.67397909 |
178 | organic cation transport (GO:0015695) | 2.66942011 |
179 | hepatocyte apoptotic process (GO:0097284) | 2.63034150 |
180 | histone H2A ubiquitination (GO:0033522) | 2.62170509 |
181 | histone H2A monoubiquitination (GO:0035518) | 2.61953573 |
182 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.61790508 |
183 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.61790508 |
184 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.61790508 |
185 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.61436206 |
186 | cilium movement (GO:0003341) | 2.60543305 |
187 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.59352208 |
188 | natural killer cell mediated immunity (GO:0002228) | 2.59352208 |
189 | meiotic nuclear division (GO:0007126) | 2.57526688 |
190 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.57408639 |
191 | ER-nucleus signaling pathway (GO:0006984) | 2.56839512 |
192 | multicellular organismal reproductive process (GO:0048609) | 2.54865311 |
193 | interferon-gamma secretion (GO:0072643) | 2.54625046 |
194 | protoporphyrinogen IX metabolic process (GO:0046501) | 10.4809751 |
Rank | Gene Set | Z-score |
---|---|---|
1 | GATA1_22025678_ChIP-Seq_K562_Human | 4.81668151 |
2 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.02844035 |
3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.81651758 |
4 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 3.49474320 |
5 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 3.40355443 |
6 | * GATA1_19941826_ChIP-Seq_K562_Human | 3.34993867 |
7 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.19031893 |
8 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 2.89045670 |
9 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 2.70291501 |
10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.67658556 |
11 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.37921287 |
12 | * GATA2_19941826_ChIP-Seq_K562_Human | 2.20867907 |
13 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 2.14294676 |
14 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.10342911 |
15 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.04387288 |
16 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.98470717 |
17 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.92761689 |
18 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.87478401 |
19 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.86196517 |
20 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.82987299 |
21 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.82838115 |
22 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.82547740 |
23 | * MYB_26560356_Chip-Seq_TH2_Human | 1.78746961 |
24 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.78518899 |
25 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.75782605 |
26 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.74301448 |
27 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70423836 |
28 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.68739137 |
29 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.68526116 |
30 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.68474653 |
31 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.67811045 |
32 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.66987115 |
33 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64997378 |
34 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61141412 |
35 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.58013702 |
36 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.57690356 |
37 | MYC_22102868_ChIP-Seq_BL_Human | 1.57301848 |
38 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.56580856 |
39 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.54005762 |
40 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.52628426 |
41 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.50827974 |
42 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.50450491 |
43 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.49899656 |
44 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.49680294 |
45 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.49678366 |
46 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.46358307 |
47 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.45348859 |
48 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.45188520 |
49 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.45013504 |
50 | * MYB_26560356_Chip-Seq_TH1_Human | 1.44455732 |
51 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.40149302 |
52 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.37368355 |
53 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.33231732 |
54 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.32558493 |
55 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.32216177 |
56 | * MAF_26560356_Chip-Seq_TH1_Human | 1.32115120 |
57 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.30204193 |
58 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.30144241 |
59 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29839249 |
60 | * NCOR1_26117541_ChIP-Seq_K562_Human | 1.27905374 |
61 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.27421685 |
62 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 1.27402307 |
63 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.26120381 |
64 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.25772363 |
65 | TP53_16413492_ChIP-PET_HCT116_Human | 1.23680719 |
66 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.20833732 |
67 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.18345211 |
68 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.17427708 |
69 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.17384861 |
70 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.10434398 |
71 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.10395645 |
72 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.09717030 |
73 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.09125282 |
74 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.06947794 |
75 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.06323390 |
76 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.05231672 |
77 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.04831229 |
78 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.04690209 |
79 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.04557949 |
80 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.02256509 |
81 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.01760410 |
82 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01520410 |
83 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.00635053 |
84 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.00563233 |
85 | * RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.00382935 |
86 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99998342 |
87 | GATA3_26560356_Chip-Seq_TH1_Human | 0.98941987 |
88 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.98889503 |
89 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.98503518 |
90 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98242182 |
91 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97384254 |
92 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.95761641 |
93 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.95488247 |
94 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.95399022 |
95 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.95384066 |
96 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.95323777 |
97 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94650769 |
98 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.93569057 |
99 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.93378052 |
100 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.92804318 |
101 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.92404062 |
102 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.92394631 |
103 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92226575 |
104 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91601302 |
105 | GATA3_26560356_Chip-Seq_TH2_Human | 0.90912499 |
106 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.90860010 |
107 | * MAF_26560356_Chip-Seq_TH2_Human | 0.90188339 |
108 | * PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.90028803 |
109 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.89729905 |
110 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.89518005 |
111 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.89495521 |
112 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.88646028 |
113 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87948973 |
114 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.87929615 |
115 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.87828450 |
116 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.87573511 |
117 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.86193768 |
118 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.86049256 |
119 | * CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85553125 |
120 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 0.85305325 |
121 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.85141041 |
122 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.84510180 |
123 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.84401582 |
124 | SPI1_23127762_ChIP-Seq_K562_Human | 0.83644982 |
125 | * TFEB_21752829_ChIP-Seq_HELA_Human | 0.82753980 |
126 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.82408915 |
127 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.82217073 |
128 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81745103 |
129 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.81650170 |
130 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.81546090 |
131 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.81449449 |
132 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.81256061 |
133 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.81009659 |
134 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.80908756 |
135 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.80657079 |
136 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.80225142 |
137 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.78641407 |
138 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.78465710 |
139 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.78269806 |
140 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.77973039 |
141 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.76575622 |
142 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.76545059 |
143 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.76505025 |
144 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.75548245 |
145 | STAT3_23295773_ChIP-Seq_U87_Human | 0.75270121 |
146 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.74584668 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003656_abnormal_erythrocyte_physiolo | 6.98877207 |
2 | MP0000569_abnormal_digit_pigmentation | 5.35191483 |
3 | MP0005410_abnormal_fertilization | 5.12914059 |
4 | MP0004147_increased_porphyrin_level | 4.19001306 |
5 | MP0005083_abnormal_biliary_tract | 2.96324741 |
6 | MP0003724_increased_susceptibility_to | 2.78806340 |
7 | MP0005451_abnormal_body_composition | 2.62918921 |
8 | MP0008877_abnormal_DNA_methylation | 2.62114740 |
9 | MP0001929_abnormal_gametogenesis | 2.61599979 |
10 | MP0004381_abnormal_hair_follicle | 2.60185067 |
11 | MP0005310_abnormal_salivary_gland | 2.44977836 |
12 | MP0000015_abnormal_ear_pigmentation | 2.37076301 |
13 | MP0003300_gastrointestinal_ulcer | 2.36458982 |
14 | MP0008057_abnormal_DNA_replication | 2.27627996 |
15 | MP0004264_abnormal_extraembryonic_tissu | 2.08957825 |
16 | MP0003698_abnormal_male_reproductive | 2.02642046 |
17 | MP0005174_abnormal_tail_pigmentation | 2.02612717 |
18 | MP0005075_abnormal_melanosome_morpholog | 1.99574623 |
19 | MP0004883_abnormal_blood_vessel | 1.93836688 |
20 | MP0001835_abnormal_antigen_presentation | 1.87540281 |
21 | MP0005058_abnormal_lysosome_morphology | 1.77971853 |
22 | MP0003221_abnormal_cardiomyocyte_apopto | 1.75190922 |
23 | MP0005464_abnormal_platelet_physiology | 1.74101818 |
24 | MP0005636_abnormal_mineral_homeostasis | 1.72289703 |
25 | MP0003111_abnormal_nucleus_morphology | 1.70252279 |
26 | MP0002332_abnormal_exercise_endurance | 1.68407713 |
27 | MP0003693_abnormal_embryo_hatching | 1.59047202 |
28 | MP0001666_abnormal_nutrient_absorption | 1.57512053 |
29 | MP0002398_abnormal_bone_marrow | 1.57237668 |
30 | MP0002396_abnormal_hematopoietic_system | 1.57013942 |
31 | MP0002693_abnormal_pancreas_physiology | 1.54972938 |
32 | MP0005671_abnormal_response_to | 1.54237303 |
33 | MP0002210_abnormal_sex_determination | 1.53379612 |
34 | MP0008260_abnormal_autophagy | 1.52668424 |
35 | MP0002877_abnormal_melanocyte_morpholog | 1.52200184 |
36 | MP0000685_abnormal_immune_system | 1.51752892 |
37 | MP0009785_altered_susceptibility_to | 1.50614922 |
38 | MP0002161_abnormal_fertility/fecundity | 1.47119276 |
39 | MP0004484_altered_response_of | 1.45296282 |
40 | MP0003303_peritoneal_inflammation | 1.43444835 |
41 | MP0000653_abnormal_sex_gland | 1.43426729 |
42 | MP0000490_abnormal_crypts_of | 1.42449278 |
43 | MP0005387_immune_system_phenotype | 1.38841506 |
44 | MP0001790_abnormal_immune_system | 1.38841506 |
45 | MP0003866_abnormal_defecation | 1.36329445 |
46 | MP0003718_maternal_effect | 1.35541075 |
47 | MP0001800_abnormal_humoral_immune | 1.33429934 |
48 | MP0002166_altered_tumor_susceptibility | 1.33344816 |
49 | MP0001145_abnormal_male_reproductive | 1.33126125 |
50 | MP0001873_stomach_inflammation | 1.32262855 |
51 | MP0002009_preneoplasia | 1.30699255 |
52 | MP0000689_abnormal_spleen_morphology | 1.30278056 |
53 | MP0005220_abnormal_exocrine_pancreas | 1.29623129 |
54 | MP0003828_pulmonary_edema | 1.29381603 |
55 | MP0010307_abnormal_tumor_latency | 1.29326517 |
56 | MP0004510_myositis | 1.28787621 |
57 | MP0005397_hematopoietic_system_phenotyp | 1.28114435 |
58 | MP0001545_abnormal_hematopoietic_system | 1.28114435 |
59 | MP0000465_gastrointestinal_hemorrhage | 1.26317437 |
60 | MP0003077_abnormal_cell_cycle | 1.25396329 |
61 | MP0002452_abnormal_antigen_presenting | 1.24831202 |
62 | MP0005000_abnormal_immune_tolerance | 1.24321192 |
63 | MP0002405_respiratory_system_inflammati | 1.20623597 |
64 | MP0002723_abnormal_immune_serum | 1.20393348 |
65 | MP0002420_abnormal_adaptive_immunity | 1.19667911 |
66 | MP0005164_abnormal_response_to | 1.19460247 |
67 | MP0003763_abnormal_thymus_physiology | 1.19359007 |
68 | MP0001819_abnormal_immune_cell | 1.18620239 |
69 | MP0002429_abnormal_blood_cell | 1.18487879 |
70 | MP0002722_abnormal_immune_system | 1.18487343 |
71 | MP0005670_abnormal_white_adipose | 1.18443563 |
72 | MP0004947_skin_inflammation | 1.18249574 |
73 | MP0003787_abnormal_imprinting | 1.17431465 |
74 | MP0009333_abnormal_splenocyte_physiolog | 1.14010838 |
75 | MP0003183_abnormal_peptide_metabolism | 1.13297874 |
76 | MP0001765_abnormal_ion_homeostasis | 1.12028361 |
77 | MP0000716_abnormal_immune_system | 1.10166122 |
78 | MP0006054_spinal_hemorrhage | 1.08901935 |
79 | MP0003699_abnormal_female_reproductive | 1.08006271 |
80 | MP0010094_abnormal_chromosome_stability | 1.06842691 |
81 | MP0003436_decreased_susceptibility_to | 1.06407232 |
82 | MP0003329_amyloid_beta_deposits | 1.06221551 |
83 | MP0003121_genomic_imprinting | 1.05581686 |
84 | MP0002419_abnormal_innate_immunity | 1.05438127 |
85 | MP0003091_abnormal_cell_migration | 1.05208024 |
86 | MP0001845_abnormal_inflammatory_respons | 1.04187419 |
87 | MP0002006_tumorigenesis | 1.03795408 |
88 | MP0005025_abnormal_response_to | 1.02109503 |
89 | MP0001944_abnormal_pancreas_morphology | 1.00841180 |
90 | MP0006082_CNS_inflammation | 0.99524523 |
91 | MP0003690_abnormal_glial_cell | 0.99291679 |
92 | MP0002138_abnormal_hepatobiliary_system | 0.98341893 |
93 | MP0000858_altered_metastatic_potential | 0.97023026 |
94 | MP0005076_abnormal_cell_differentiation | 0.94780549 |
95 | MP0000609_abnormal_liver_physiology | 0.94765593 |
96 | MP0004130_abnormal_muscle_cell | 0.94094098 |
97 | MP0001851_eye_inflammation | 0.93119014 |
98 | MP0000604_amyloidosis | 0.91601557 |
99 | MP0002019_abnormal_tumor_incidence | 0.91558890 |
100 | MP0000371_diluted_coat_color | 0.90322710 |
101 | MP0004808_abnormal_hematopoietic_stem | 0.88898346 |
102 | MP0003868_abnormal_feces_composition | 0.88810615 |
103 | MP0005365_abnormal_bile_salt | 0.88075915 |
104 | MP0000703_abnormal_thymus_morphology | 0.86669784 |
105 | MP0001119_abnormal_female_reproductive | 0.86346653 |
106 | MP0003172_abnormal_lysosome_physiology | 0.84974208 |
107 | MP0005266_abnormal_metabolism | 0.84816593 |
108 | MP0003646_muscle_fatigue | 0.84536907 |
109 | MP0010155_abnormal_intestine_physiology | 0.84164936 |
110 | MP0005408_hypopigmentation | 0.83685794 |
111 | MP0002132_abnormal_respiratory_system | 0.83359822 |
112 | MP0009643_abnormal_urine_homeostasis | 0.82661588 |
113 | MP0005376_homeostasis/metabolism_phenot | 0.82428278 |
114 | MP0008469_abnormal_protein_level | 0.82030086 |
115 | MP0009764_decreased_sensitivity_to | 0.79888673 |
116 | MP0003632_abnormal_nervous_system | 0.79710129 |
117 | MP0002928_abnormal_bile_duct | 0.78562546 |
118 | MP0003191_abnormal_cellular_cholesterol | 0.76229526 |
119 | MP0002139_abnormal_hepatobiliary_system | 0.75969921 |
120 | MP0005621_abnormal_cell_physiology | 0.75597473 |
121 | MP0005395_other_phenotype | 0.75278683 |
122 | MP0000427_abnormal_hair_cycle | 0.75087054 |
123 | MP0008995_early_reproductive_senescence | 0.74593254 |
124 | MP0000313_abnormal_cell_death | 0.74438266 |
125 | MP0004185_abnormal_adipocyte_glucose | 0.74111755 |
126 | MP0001533_abnormal_skeleton_physiology | 0.71235997 |
127 | MP0003186_abnormal_redox_activity | 0.70978841 |
128 | MP0009765_abnormal_xenobiotic_induced | 0.70299834 |
129 | MP0001919_abnormal_reproductive_system | 0.69920617 |
130 | MP0003453_abnormal_keratinocyte_physiol | 0.68757962 |
131 | MP0000350_abnormal_cell_proliferation | 0.68486406 |
132 | MP0002148_abnormal_hypersensitivity_rea | 0.68406366 |
133 | MP0000598_abnormal_liver_morphology | 0.68401096 |
134 | MP0008874_decreased_physiological_sensi | 0.68332677 |
135 | MP0009763_increased_sensitivity_to | 0.67191011 |
136 | MP0001958_emphysema | 0.65780170 |
137 | MP0001663_abnormal_digestive_system | 0.63273154 |
138 | MP0002136_abnormal_kidney_physiology | 0.61101929 |
139 | MP0002095_abnormal_skin_pigmentation | 0.59554966 |
140 | MP0000249_abnormal_blood_vessel | 0.56740439 |
141 | MP0002971_abnormal_brown_adipose | 0.55891194 |
142 | MP0002998_abnormal_bone_remodeling | 0.55652650 |
143 | MP0005384_cellular_phenotype | 0.55063272 |
144 | MP0003045_fibrosis | 0.54606654 |
145 | MP0005409_darkened_coat_color | 0.52164793 |
146 | MP0001853_heart_inflammation | 0.50969438 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Poikilocytosis (HP:0004447) | 9.13816161 |
2 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 6.57493493 |
3 | Hypochromic microcytic anemia (HP:0004840) | 6.56053814 |
4 | Acanthocytosis (HP:0001927) | 6.21312011 |
5 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.82055528 |
6 | Male infertility (HP:0003251) | 5.03824557 |
7 | Infertility (HP:0000789) | 4.81444629 |
8 | Absent/shortened dynein arms (HP:0200106) | 4.66497142 |
9 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.66497142 |
10 | Reticulocytosis (HP:0001923) | 4.63677342 |
11 | Nasal polyposis (HP:0100582) | 4.60753080 |
12 | Cholelithiasis (HP:0001081) | 4.45667808 |
13 | Gastrointestinal infarctions (HP:0005244) | 4.33449724 |
14 | Abnormal gallbladder morphology (HP:0012437) | 4.06706231 |
15 | Slow saccadic eye movements (HP:0000514) | 4.02069980 |
16 | Gingival bleeding (HP:0000225) | 3.95352062 |
17 | Abnormality of the nasal mucosa (HP:0000433) | 3.84586174 |
18 | Chronic bronchitis (HP:0004469) | 3.82926955 |
19 | Optic neuritis (HP:0100653) | 3.77519399 |
20 | Retrobulbar optic neuritis (HP:0100654) | 3.77519399 |
21 | Postural instability (HP:0002172) | 3.75796676 |
22 | Myositis (HP:0100614) | 3.60262135 |
23 | Tetraparesis (HP:0002273) | 3.55674971 |
24 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.55118494 |
25 | Orchitis (HP:0100796) | 3.47965808 |
26 | Recurrent skin infections (HP:0001581) | 3.46350675 |
27 | Visual hallucinations (HP:0002367) | 3.46060681 |
28 | Gingivitis (HP:0000230) | 3.38219080 |
29 | Bronchiectasis (HP:0002110) | 3.37517021 |
30 | Microcytic anemia (HP:0001935) | 3.36664695 |
31 | Hypochromic anemia (HP:0001931) | 3.31854401 |
32 | Bronchitis (HP:0012387) | 3.29306852 |
33 | Abnormality of T cells (HP:0002843) | 3.25984607 |
34 | Recurrent sinusitis (HP:0011108) | 3.25376520 |
35 | Heterotopia (HP:0002282) | 3.24685940 |
36 | Leukocytosis (HP:0001974) | 3.15753682 |
37 | Spontaneous hematomas (HP:0007420) | 3.14992274 |
38 | Peritonitis (HP:0002586) | 3.14259383 |
39 | Rhinitis (HP:0012384) | 3.10895619 |
40 | Stomatitis (HP:0010280) | 3.09777582 |
41 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.06545784 |
42 | Recurrent cutaneous fungal infections (HP:0011370) | 3.06545784 |
43 | Paralysis (HP:0003470) | 3.03903881 |
44 | Hyperbilirubinemia (HP:0002904) | 3.00182136 |
45 | Cholecystitis (HP:0001082) | 2.99242919 |
46 | Abnormal gallbladder physiology (HP:0012438) | 2.99242919 |
47 | Osteomalacia (HP:0002749) | 2.98926716 |
48 | Subacute progressive viral hepatitis (HP:0006572) | 2.96206496 |
49 | Conjunctival telangiectasia (HP:0000524) | 2.95127442 |
50 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.94837058 |
51 | Recurrent bronchitis (HP:0002837) | 2.93560116 |
52 | Abnormality of the fingertips (HP:0001211) | 2.90401598 |
53 | Pustule (HP:0200039) | 2.90161863 |
54 | Periodontitis (HP:0000704) | 2.89781459 |
55 | Arterial thrombosis (HP:0004420) | 2.89646028 |
56 | Cortical dysplasia (HP:0002539) | 2.83436940 |
57 | Abnormality of macrophages (HP:0004311) | 2.83324715 |
58 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.81662287 |
59 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.81662287 |
60 | Diaphragmatic weakness (HP:0009113) | 2.77702728 |
61 | Abnormality of the gallbladder (HP:0005264) | 2.75061958 |
62 | Orthostatic hypotension (HP:0001278) | 2.74992445 |
63 | Keratoconjunctivitis sicca (HP:0001097) | 2.74379663 |
64 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.73708737 |
65 | Vasculitis (HP:0002633) | 2.73345882 |
66 | Chest pain (HP:0100749) | 2.72777609 |
67 | Polycythemia (HP:0001901) | 2.71878638 |
68 | Resting tremor (HP:0002322) | 2.67666702 |
69 | Hypoplasia of the thymus (HP:0000778) | 2.65629860 |
70 | Eosinophilia (HP:0001880) | 2.61709665 |
71 | Abnormality of reticulocytes (HP:0004312) | 2.61686958 |
72 | Petechiae (HP:0000967) | 2.60331536 |
73 | Colitis (HP:0002583) | 2.58608562 |
74 | Acute hepatic failure (HP:0006554) | 2.58389522 |
75 | Keratoconjunctivitis (HP:0001096) | 2.58059917 |
76 | Cutaneous photosensitivity (HP:0000992) | 2.55358761 |
77 | Meningitis (HP:0001287) | 2.53114833 |
78 | Recurrent otitis media (HP:0000403) | 2.49642709 |
79 | Global brain atrophy (HP:0002283) | 2.45759081 |
80 | Encephalitis (HP:0002383) | 2.42269350 |
81 | Autoimmune hemolytic anemia (HP:0001890) | 2.39541643 |
82 | Abnormality of eosinophils (HP:0001879) | 2.38026942 |
83 | Viral hepatitis (HP:0006562) | 2.37285662 |
84 | Hyperkalemia (HP:0002153) | 2.35561564 |
85 | IgA deficiency (HP:0002720) | 2.34538188 |
86 | Glucose intolerance (HP:0000833) | 2.29193567 |
87 | Granulocytopenia (HP:0001913) | 2.28120996 |
88 | Cerebral inclusion bodies (HP:0100314) | 2.27119687 |
89 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.25330859 |
90 | Hemoptysis (HP:0002105) | 2.24363980 |
91 | Abnormal ciliary motility (HP:0012262) | 2.23669474 |
92 | Mediastinal lymphadenopathy (HP:0100721) | 2.23605556 |
93 | Recurrent abscess formation (HP:0002722) | 2.23157702 |
94 | Abnormal spermatogenesis (HP:0008669) | 2.22103311 |
95 | Urticaria (HP:0001025) | 2.21220276 |
96 | Inflammation of the large intestine (HP:0002037) | 2.20692341 |
97 | Prominent nose (HP:0000448) | 2.20353616 |
98 | Thyroiditis (HP:0100646) | 2.19844699 |
99 | Recurrent viral infections (HP:0004429) | 2.18103173 |
100 | Hemorrhage of the eye (HP:0011885) | 2.15721125 |
101 | Obstructive lung disease (HP:0006536) | 2.11664150 |
102 | Chronic obstructive pulmonary disease (HP:0006510) | 2.11664150 |
103 | Abnormal platelet volume (HP:0011876) | 2.10322854 |
104 | Autoimmune thrombocytopenia (HP:0001973) | 2.09236442 |
105 | Aortic aneurysm (HP:0004942) | 2.06027878 |
106 | Gastrointestinal inflammation (HP:0004386) | 2.05649391 |
107 | Papilloma (HP:0012740) | 2.03966386 |
108 | Verrucae (HP:0200043) | 2.03966386 |
109 | Increased mean platelet volume (HP:0011877) | 2.02588897 |
110 | Truncal obesity (HP:0001956) | 2.01200540 |
111 | Recurrent bacterial skin infections (HP:0005406) | 2.00842039 |
112 | Cellulitis (HP:0100658) | 2.00759898 |
113 | Zonular cataract (HP:0010920) | 1.99983559 |
114 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.98995211 |
115 | Anorexia (HP:0002039) | 1.98727982 |
116 | Impaired platelet aggregation (HP:0003540) | 1.97276596 |
117 | Abnormal platelet function (HP:0011869) | 1.97276596 |
118 | Insomnia (HP:0100785) | 1.96995274 |
119 | Thyroid carcinoma (HP:0002890) | 1.95729597 |
120 | Exocrine pancreatic insufficiency (HP:0001738) | 1.94363824 |
121 | Dysautonomia (HP:0002459) | 1.93295213 |
122 | Increased cerebral lipofuscin (HP:0011813) | 1.93234009 |
123 | Stomach cancer (HP:0012126) | 1.92537838 |
124 | Abnormal glucose tolerance (HP:0001952) | 1.91768829 |
125 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.90848828 |
126 | Papillary thyroid carcinoma (HP:0002895) | 1.90771012 |
127 | Ocular albinism (HP:0001107) | 1.88193503 |
128 | Hematochezia (HP:0002573) | 1.87458077 |
129 | Lymphopenia (HP:0001888) | 1.86405013 |
130 | IgG deficiency (HP:0004315) | 1.85356984 |
131 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.84604318 |
132 | IgM deficiency (HP:0002850) | 1.82094911 |
133 | Bilateral sensorineural hearing impairment (HP:0008619) | 1.81058954 |
134 | Eczematoid dermatitis (HP:0000976) | 1.80084992 |
135 | Impulsivity (HP:0100710) | 1.75152435 |
136 | Retinal atrophy (HP:0001105) | 1.75020560 |
137 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.73075824 |
138 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.72415835 |
139 | Premature ovarian failure (HP:0008209) | 1.71766284 |
140 | Dysostosis multiplex (HP:0000943) | 1.70725671 |
141 | Myocardial infarction (HP:0001658) | 1.68316720 |
142 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.67986641 |
143 | Azoospermia (HP:0000027) | 1.65203431 |
144 | Generalized hyperpigmentation (HP:0007440) | 1.64154120 |
145 | Vacuolated lymphocytes (HP:0001922) | 1.61681424 |
146 | T lymphocytopenia (HP:0005403) | 1.59354802 |
147 | Recurrent fungal infections (HP:0002841) | 1.55005033 |
148 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.54971981 |
149 | Villous atrophy (HP:0011473) | 1.54971981 |
150 | Abnormality of T cell physiology (HP:0011840) | 1.53840884 |
151 | Nuclear cataract (HP:0100018) | 1.53816756 |
152 | Increased CSF protein (HP:0002922) | 1.52660651 |
153 | Agammaglobulinemia (HP:0004432) | 1.51089120 |
154 | Prolonged bleeding time (HP:0003010) | 1.50810304 |
155 | Fatigue (HP:0012378) | 1.47886284 |
156 | Abnormality of T cell number (HP:0011839) | 1.47539317 |
157 | Status epilepticus (HP:0002133) | 1.47018223 |
158 | Epistaxis (HP:0000421) | 1.46639599 |
159 | Onycholysis (HP:0001806) | 1.45812803 |
160 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.44206181 |
161 | Pulmonary infiltrates (HP:0002113) | 1.44118366 |
162 | Tubulointerstitial fibrosis (HP:0005576) | 1.43861472 |
163 | Hepatocellular carcinoma (HP:0001402) | 1.43188582 |
164 | Spondylolisthesis (HP:0003302) | 1.42909283 |
165 | Osteomyelitis (HP:0002754) | 1.42675599 |
166 | Nephronophthisis (HP:0000090) | 1.42634071 |
167 | Ileus (HP:0002595) | 1.42483450 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TAOK3 | 5.15476960 |
2 | EIF2AK1 | 4.15241295 |
3 | EEF2K | 3.04687401 |
4 | PRKD3 | 2.72020378 |
5 | BLK | 2.65727167 |
6 | MAP2K3 | 2.55003275 |
7 | FGR | 2.52722056 |
8 | STK10 | 2.41185741 |
9 | PDK4 | 2.40247810 |
10 | PDK3 | 2.40247810 |
11 | SGK2 | 2.24809024 |
12 | ERN1 | 2.20859209 |
13 | CDK12 | 2.17951614 |
14 | WNK1 | 2.04296478 |
15 | TESK1 | 2.03343754 |
16 | PDK2 | 2.03053853 |
17 | STK4 | 2.00052600 |
18 | PIK3CG | 1.99690454 |
19 | GRK5 | 1.98022364 |
20 | CSK | 1.95548150 |
21 | MAP4K1 | 1.92970722 |
22 | STK3 | 1.92495293 |
23 | IRAK3 | 1.84716387 |
24 | PLK2 | 1.76701670 |
25 | FGFR3 | 1.73385530 |
26 | LATS1 | 1.69674069 |
27 | FES | 1.61553154 |
28 | TGFBR2 | 1.60545327 |
29 | PIM1 | 1.60482846 |
30 | MAP3K13 | 1.56774375 |
31 | TRIB3 | 1.55450812 |
32 | TYK2 | 1.52437976 |
33 | MAP3K3 | 1.47385703 |
34 | MAPKAPK3 | 1.44666198 |
35 | IKBKE | 1.42543726 |
36 | NEK2 | 1.40738220 |
37 | SGK223 | 1.38885436 |
38 | SGK494 | 1.38885436 |
39 | DYRK1B | 1.37267331 |
40 | BTK | 1.36820325 |
41 | ICK | 1.36603221 |
42 | TBK1 | 1.35010715 |
43 | ZAP70 | 1.30163561 |
44 | JAK3 | 1.28746492 |
45 | TLK1 | 1.26530616 |
46 | MAP3K1 | 1.25743676 |
47 | NLK | 1.23215456 |
48 | MOS | 1.19670535 |
49 | CAMKK2 | 1.18613042 |
50 | ERBB2 | 1.18520513 |
51 | MELK | 1.17453063 |
52 | MARK2 | 1.17079124 |
53 | HCK | 1.16758916 |
54 | DYRK3 | 1.15911458 |
55 | TTK | 1.15910315 |
56 | MARK3 | 1.15127659 |
57 | CDK9 | 1.14702326 |
58 | TEC | 1.13056509 |
59 | JAK2 | 1.10934472 |
60 | CDK6 | 1.08300857 |
61 | MAP3K10 | 1.08035452 |
62 | CHEK2 | 1.04557781 |
63 | MAP3K6 | 1.02861908 |
64 | TAOK1 | 1.02739213 |
65 | SYK | 1.01353231 |
66 | CHUK | 1.01219489 |
67 | YES1 | 1.00499070 |
68 | JAK1 | 0.98084964 |
69 | PRPF4B | 0.97046803 |
70 | MAP3K8 | 0.96659139 |
71 | PRKAA1 | 0.96478526 |
72 | IKBKB | 0.95046195 |
73 | PDK1 | 0.92780163 |
74 | DYRK1A | 0.91908909 |
75 | TAOK2 | 0.90361895 |
76 | IRAK4 | 0.89611408 |
77 | MAP3K11 | 0.88545987 |
78 | TRPM7 | 0.82995436 |
79 | IRAK2 | 0.80182751 |
80 | KSR1 | 0.80007813 |
81 | KSR2 | 0.79664820 |
82 | ACVR1B | 0.79358426 |
83 | NEK6 | 0.78945761 |
84 | SGK1 | 0.78914084 |
85 | SCYL2 | 0.76846405 |
86 | BMPR2 | 0.72618459 |
87 | AKT3 | 0.71893931 |
88 | EPHB1 | 0.71474297 |
89 | STK11 | 0.71450224 |
90 | MAP3K5 | 0.69994100 |
91 | ZAK | 0.69563906 |
92 | HIPK2 | 0.67528313 |
93 | NEK9 | 0.66675107 |
94 | MATK | 0.66209269 |
95 | RAF1 | 0.63650676 |
96 | WNK4 | 0.62946862 |
97 | MAPK15 | 0.62644282 |
98 | FRK | 0.61261610 |
99 | MAP3K2 | 0.60534204 |
100 | EGFR | 0.60390395 |
101 | CDK4 | 0.60256958 |
102 | PDPK1 | 0.60146370 |
103 | PKN2 | 0.58937681 |
104 | GRK6 | 0.58489251 |
105 | ITK | 0.58479909 |
106 | MAP3K7 | 0.58113626 |
107 | INSRR | 0.57902039 |
108 | RIPK4 | 0.57576711 |
109 | MAPK11 | 0.56662100 |
110 | PAK3 | 0.56454477 |
111 | CAMK1D | 0.54895412 |
112 | PTK2B | 0.53859560 |
113 | IRAK1 | 0.53649990 |
114 | CSF1R | 0.53043639 |
115 | MAP2K2 | 0.52952593 |
116 | STK38 | 0.52829756 |
117 | PRKAA2 | 0.52414050 |
118 | RPS6KA5 | 0.52308661 |
119 | AURKB | 0.52153532 |
120 | PRKD2 | 0.52145754 |
121 | MAP3K14 | 0.52072500 |
122 | MTOR | 0.50601831 |
123 | CAMK4 | 0.50412522 |
124 | PLK4 | 0.49504197 |
125 | RET | 0.47950029 |
126 | SGK3 | 0.47727665 |
127 | CDC7 | 0.47461783 |
128 | BRAF | 0.46945543 |
129 | TXK | 0.45864370 |
130 | CAMK1G | 0.44978257 |
131 | CHEK1 | 0.44749083 |
132 | BRD4 | 0.43961316 |
133 | RIPK1 | 0.43441175 |
134 | TNK2 | 0.43439932 |
135 | PRKCQ | 0.43371152 |
136 | STK24 | 0.43019081 |
137 | LCK | 0.42370456 |
138 | ATM | 0.41887427 |
139 | ADRBK1 | 0.41727959 |
140 | PTK6 | 0.41246729 |
141 | PASK | 0.40778206 |
142 | BRSK2 | 0.40464521 |
143 | BRSK1 | 0.40396791 |
144 | LRRK2 | 0.39132310 |
145 | LYN | 0.38945428 |
146 | FGFR4 | 0.38882673 |
147 | PDGFRB | 0.38148643 |
148 | BCKDK | 0.37871385 |
149 | MST4 | 0.36096980 |
150 | CAMKK1 | 0.34842333 |
151 | FGFR2 | 0.33859051 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 4.39989059 |
2 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 3.76787843 |
3 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 3.04145188 |
4 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.72043856 |
5 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.51622607 |
6 | Other glycan degradation_Homo sapiens_hsa00511 | 2.12333420 |
7 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.11949584 |
8 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.85829827 |
9 | Protein export_Homo sapiens_hsa03060 | 1.69450680 |
10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.63547059 |
11 | ABC transporters_Homo sapiens_hsa02010 | 1.58087315 |
12 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.55513257 |
13 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.54635258 |
14 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.52873258 |
15 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.52240716 |
16 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.45076679 |
17 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.44323015 |
18 | Endometrial cancer_Homo sapiens_hsa05213 | 1.39958822 |
19 | Measles_Homo sapiens_hsa05162 | 1.38529609 |
20 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.37629245 |
21 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.31905074 |
22 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.30962234 |
23 | Lysosome_Homo sapiens_hsa04142 | 1.30326432 |
24 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.29703826 |
25 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.27470323 |
26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.27267884 |
27 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.26071525 |
28 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.24397380 |
29 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.22638304 |
30 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.21896864 |
31 | Influenza A_Homo sapiens_hsa05164 | 1.20491029 |
32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.19333421 |
33 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.18947762 |
34 | Allograft rejection_Homo sapiens_hsa05330 | 1.18170226 |
35 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.17869803 |
36 | Apoptosis_Homo sapiens_hsa04210 | 1.17424953 |
37 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.16556656 |
38 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.16064078 |
39 | Malaria_Homo sapiens_hsa05144 | 1.09148566 |
40 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.08470384 |
41 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.06933316 |
42 | Leishmaniasis_Homo sapiens_hsa05140 | 1.06669509 |
43 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.06623418 |
44 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.05577317 |
45 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.05550686 |
46 | Alcoholism_Homo sapiens_hsa05034 | 1.05357275 |
47 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.05212062 |
48 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.03747775 |
49 | Cell cycle_Homo sapiens_hsa04110 | 1.03365523 |
50 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.02760218 |
51 | Basal transcription factors_Homo sapiens_hsa03022 | 1.02351096 |
52 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.00470722 |
53 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.99658661 |
54 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.99137896 |
55 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.95614193 |
56 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.95446944 |
57 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.94118168 |
58 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.93990546 |
59 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.93476634 |
60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.92334317 |
61 | Hepatitis B_Homo sapiens_hsa05161 | 0.91099488 |
62 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.90957569 |
63 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.89701717 |
64 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.89313452 |
65 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.89122866 |
66 | Prostate cancer_Homo sapiens_hsa05215 | 0.88530936 |
67 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.88500343 |
68 | Legionellosis_Homo sapiens_hsa05134 | 0.85317053 |
69 | Glioma_Homo sapiens_hsa05214 | 0.84565803 |
70 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.84484091 |
71 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.83725535 |
72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.83218737 |
73 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.81989279 |
74 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.79933598 |
75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.79018258 |
76 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.78444489 |
77 | Insulin resistance_Homo sapiens_hsa04931 | 0.77404900 |
78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76482116 |
79 | Long-term potentiation_Homo sapiens_hsa04720 | 0.76079016 |
80 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.75486908 |
81 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.74903843 |
82 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.73375960 |
83 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.73066696 |
84 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.71451106 |
85 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.71288803 |
86 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.71175365 |
87 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.70534512 |
88 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.69645216 |
89 | Thyroid cancer_Homo sapiens_hsa05216 | 0.68728556 |
90 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.67567209 |
91 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.67417532 |
92 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.67165484 |
93 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.64816534 |
94 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.64184128 |
95 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.64075783 |
96 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.63970773 |
97 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.63812919 |
98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63166981 |
99 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.62770719 |
100 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.62576767 |
101 | Phagosome_Homo sapiens_hsa04145 | 0.62299590 |
102 | Tuberculosis_Homo sapiens_hsa05152 | 0.61767651 |
103 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61681224 |
104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.60370848 |
105 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.59809616 |
106 | Circadian rhythm_Homo sapiens_hsa04710 | 0.59362325 |
107 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.58769142 |
108 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58308301 |
109 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.56344035 |
110 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.54998308 |
111 | Mineral absorption_Homo sapiens_hsa04978 | 0.54471610 |
112 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.54395081 |
113 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.53986189 |
114 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.53807700 |
115 | Endocytosis_Homo sapiens_hsa04144 | 0.51733469 |
116 | Hepatitis C_Homo sapiens_hsa05160 | 0.50723568 |
117 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.50723377 |
118 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.49983774 |
119 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.48685549 |
120 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.48545908 |
121 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.48150462 |
122 | Viral myocarditis_Homo sapiens_hsa05416 | 0.47573406 |
123 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.47266047 |
124 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.47224490 |
125 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.46631582 |
126 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.44967482 |
127 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.44850337 |
128 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.44558751 |
129 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.44497694 |
130 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.43566030 |
131 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43119679 |
132 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.42952760 |
133 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.42790844 |
134 | HTLV-I infection_Homo sapiens_hsa05166 | 0.42293712 |
135 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.41909723 |
136 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.41742081 |
137 | Platelet activation_Homo sapiens_hsa04611 | 0.40869130 |
138 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.40782799 |
139 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40029141 |