FAM47C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a product belonging to a family of proteins with unknown function. The coding sequence of this family member includes several tandemly repeated regions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of RNA splicing (GO:0033120)9.67677620
2binding of sperm to zona pellucida (GO:0007339)9.33528735
3cell-cell recognition (GO:0009988)9.18336517
4negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.18063556
5axonemal dynein complex assembly (GO:0070286)9.14064336
6reproduction (GO:0000003)8.98945698
7epithelial cilium movement (GO:0003351)8.88217208
8cAMP biosynthetic process (GO:0006171)8.86768668
9auditory receptor cell differentiation (GO:0042491)8.80509266
10cilium or flagellum-dependent cell motility (GO:0001539)8.63308365
11motile cilium assembly (GO:0044458)8.57160025
12detection of chemical stimulus involved in sensory perception (GO:0050907)8.46898151
13negative regulation of alpha-beta T cell differentiation (GO:0046639)8.37427953
14spermatid development (GO:0007286)8.16274600
15enteric nervous system development (GO:0048484)7.88721581
16regulation of protein sumoylation (GO:0033233)7.54897766
17piRNA metabolic process (GO:0034587)7.42253147
18cilium movement (GO:0003341)7.14153647
19synaptic transmission, dopaminergic (GO:0001963)7.05314862
20dendritic spine morphogenesis (GO:0060997)7.01158861
21single fertilization (GO:0007338)6.99023794
22positive regulation of mitochondrial fission (GO:0090141)6.98770450
23righting reflex (GO:0060013)6.96255181
24regulation of cilium movement (GO:0003352)6.66755935
25heterotypic cell-cell adhesion (GO:0034113)6.55895058
26male meiosis (GO:0007140)6.45563921
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.42171226
28inner ear receptor cell development (GO:0060119)6.38511966
29positive regulation of T-helper 1 type immune response (GO:0002827)6.30741873
30detection of chemical stimulus (GO:0009593)6.09531899
31icosanoid secretion (GO:0032309)6.06214152
32arachidonic acid secretion (GO:0050482)6.06214152
33synaptonemal complex organization (GO:0070193)6.03730534
34spermatogenesis (GO:0007283)6.02727094
35hepatocyte apoptotic process (GO:0097284)6.02048803
36male gamete generation (GO:0048232)6.00104857
37synaptonemal complex assembly (GO:0007130)5.96730406
38endothelial cell differentiation (GO:0045446)5.95348970
39sperm capacitation (GO:0048240)5.92436563
40post-embryonic morphogenesis (GO:0009886)5.85279304
41fertilization (GO:0009566)5.80857266
42positive regulation of T-helper cell differentiation (GO:0045624)5.79949880
43negative regulation of inclusion body assembly (GO:0090084)5.78077018
44microtubule depolymerization (GO:0007019)5.74751714
45gamete generation (GO:0007276)5.54510825
46phosphatidylinositol acyl-chain remodeling (GO:0036149)5.45727969
47organic cation transport (GO:0015695)5.40946784
48hair cell differentiation (GO:0035315)5.38051406
49single strand break repair (GO:0000012)5.34977196
50drug transmembrane transport (GO:0006855)5.31038377
51regulation of mitochondrial fission (GO:0090140)5.14934837
52phosphatidylserine acyl-chain remodeling (GO:0036150)5.12483207
53fatty acid derivative transport (GO:1901571)5.03277540
54icosanoid transport (GO:0071715)5.03277540
55neuronal ion channel clustering (GO:0045161)5.02554370
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.01266205
57inner ear receptor cell differentiation (GO:0060113)4.93146913
58DNA methylation involved in gamete generation (GO:0043046)4.87613676
59negative regulation of alpha-beta T cell activation (GO:0046636)4.84937799
60spermatid nucleus differentiation (GO:0007289)4.83129166
61chemosensory behavior (GO:0007635)4.78701116
62hyaluronan catabolic process (GO:0030214)4.75635534
63neural tube formation (GO:0001841)4.72459721
64cellular process involved in reproduction in multicellular organism (GO:0022412)4.70769969
65calcium ion-dependent exocytosis (GO:0017156)4.68774999
66cell recognition (GO:0008037)4.65498389
67germ cell development (GO:0007281)4.56180777
68regulation of T-helper 1 type immune response (GO:0002825)4.54029958
69ventricular system development (GO:0021591)4.53982510
70embryonic digestive tract morphogenesis (GO:0048557)4.53237746
71regulation of inclusion body assembly (GO:0090083)4.45481710
72cyclic purine nucleotide metabolic process (GO:0052652)4.43448033
73nephron epithelium morphogenesis (GO:0072088)4.42333530
74nephron tubule morphogenesis (GO:0072078)4.42333530
75positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.41260499
76vocalization behavior (GO:0071625)4.39015020
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.34841102
78ATP hydrolysis coupled proton transport (GO:0015991)4.34841102
79retina layer formation (GO:0010842)4.33677266
80multicellular organismal reproductive process (GO:0048609)4.33621773
81cyclic nucleotide biosynthetic process (GO:0009190)4.28694844
82positive regulation of membrane potential (GO:0045838)4.26675652
83attachment of spindle microtubules to kinetochore (GO:0008608)4.26284752
84cellular response to glucagon stimulus (GO:0071377)4.22793825
85regulation of microtubule-based movement (GO:0060632)4.21199750
86regulation of cAMP-mediated signaling (GO:0043949)4.21093030
87regulation of T-helper cell differentiation (GO:0045622)4.21084436
88negative regulation of actin filament bundle assembly (GO:0032232)4.19788749
89response to dietary excess (GO:0002021)4.19619214
90negative regulation of organelle assembly (GO:1902116)4.18294205
91regulation of type 2 immune response (GO:0002828)4.17051642
92glycerol ether metabolic process (GO:0006662)4.14196121
93chromosome organization involved in meiosis (GO:0070192)4.12638996
94microtubule severing (GO:0051013)4.11045356
95water transport (GO:0006833)4.10142234
96inner ear receptor stereocilium organization (GO:0060122)4.04263510
97dendritic spine organization (GO:0097061)4.01083873
98mitochondrial fusion (GO:0008053)4.00324999
99male meiosis I (GO:0007141)3.99728810
100cAMP metabolic process (GO:0046058)3.98709116
101protein localization to synapse (GO:0035418)3.97008195
102seminiferous tubule development (GO:0072520)3.93189628
103cytoskeletal anchoring at plasma membrane (GO:0007016)3.88925242
104positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.87785047
105negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81914405
106ether metabolic process (GO:0018904)3.80425104
107genitalia morphogenesis (GO:0035112)3.79591095
108cellular zinc ion homeostasis (GO:0006882)3.77614177
109chromosome condensation (GO:0030261)3.74613638
110monoamine transport (GO:0015844)3.74277981
111negative regulation of T cell differentiation (GO:0045581)3.70100303
112mechanoreceptor differentiation (GO:0042490)3.66657973
113fluid transport (GO:0042044)3.66462724
114drug transport (GO:0015893)3.62451999
115phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.61740233
116leukotriene biosynthetic process (GO:0019370)3.59148849
117meiotic nuclear division (GO:0007126)3.55623017
118DNA packaging (GO:0006323)3.55469369
119positive regulation of protein targeting to membrane (GO:0090314)3.55354221
120left/right pattern formation (GO:0060972)3.52384879
121cellular response to ATP (GO:0071318)3.49374016
122pre-miRNA processing (GO:0031054)3.49070493
123sulfur amino acid catabolic process (GO:0000098)3.48982122
124multicellular organismal development (GO:0007275)3.48932498
125sequestering of metal ion (GO:0051238)3.47818370
126negative regulation of homotypic cell-cell adhesion (GO:0034111)3.44193942
127positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.36746433
128positive regulation of alpha-beta T cell differentiation (GO:0046638)3.33325408
129carnitine transport (GO:0015879)3.31696804
130amino-acid betaine transport (GO:0015838)3.31696804
131regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.31437648
132carnitine transmembrane transport (GO:1902603)3.25018199
133negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.19355327
134renal tubule morphogenesis (GO:0061333)3.18804000
135response to glucagon (GO:0033762)3.15690497
136neuromuscular process controlling posture (GO:0050884)3.15475187
137glucocorticoid biosynthetic process (GO:0006704)3.14736675
138negative regulation of astrocyte differentiation (GO:0048712)3.13840265
139phosphatidylcholine acyl-chain remodeling (GO:0036151)3.13604796
140positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12665751
141sexual reproduction (GO:0019953)3.12526139
142left/right axis specification (GO:0070986)3.10962638
143peptidyl-threonine dephosphorylation (GO:0035970)3.10348752
144neurofilament cytoskeleton organization (GO:0060052)3.10047054
145prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.09842157
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09072598
147adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.07067225
148adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06285305
149meiosis I (GO:0007127)3.03114514
150positive regulation of steroid hormone secretion (GO:2000833)3.02563694
151meiotic cell cycle (GO:0051321)3.01946079
152chaperone-mediated protein complex assembly (GO:0051131)2.96401607
153alditol metabolic process (GO:0019400)2.94750594
154protein localization to cilium (GO:0061512)2.93778908
155microtubule polymerization or depolymerization (GO:0031109)2.91534804
156polyol catabolic process (GO:0046174)2.83788789
157mitotic sister chromatid cohesion (GO:0007064)2.83446654
158RNA destabilization (GO:0050779)2.83150287
159cilium organization (GO:0044782)2.78364940
160cell redox homeostasis (GO:0045454)2.77829623
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76828142
162synapsis (GO:0007129)2.74816740
163calcium ion import (GO:0070509)2.74076172
164cilium assembly (GO:0042384)2.72791028
165protein polyglutamylation (GO:0018095)2.71346490
166cellular component assembly involved in morphogenesis (GO:0010927)2.67259411
167polyol transport (GO:0015791)2.66866651
168sequestering of actin monomers (GO:0042989)2.58125952
169lactate metabolic process (GO:0006089)2.56492746
170nucleoside diphosphate phosphorylation (GO:0006165)2.55448822
171glycerol metabolic process (GO:0006071)2.54524911
172microtubule-based movement (GO:0007018)2.49943467
173regulation of centriole replication (GO:0046599)2.49185940
174GTP biosynthetic process (GO:0006183)2.47036373
175regulation of acrosome reaction (GO:0060046)2.45536203
176nucleus organization (GO:0006997)2.43775940
177glycolytic process (GO:0006096)2.42892331
178protein K11-linked deubiquitination (GO:0035871)2.42602692
179tooth mineralization (GO:0034505)14.3937991
180fusion of sperm to egg plasma membrane (GO:0007342)13.8306184
181detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.6437606
182sperm motility (GO:0030317)12.2837239
183positive regulation of protein sumoylation (GO:0033235)11.9868850
184negative regulation of T-helper cell differentiation (GO:0045623)11.4225028
185negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.4225028
186acrosome assembly (GO:0001675)11.0604803
187cell wall macromolecule catabolic process (GO:0016998)10.7351071
188cell wall macromolecule metabolic process (GO:0044036)10.7351071
189multicellular organism reproduction (GO:0032504)10.6649414
190plasma membrane fusion (GO:0045026)10.4736118
191acrosome reaction (GO:0007340)10.3504771
192sperm-egg recognition (GO:0035036)10.3361748
193regulation of T-helper 1 cell differentiation (GO:0045625)10.2960573
194regulation of T-helper 2 cell differentiation (GO:0045628)10.1537276
195negative regulation of type 2 immune response (GO:0002829)10.1097866
196activation of protein kinase A activity (GO:0034199)10.1062291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.54812665
2EZH2_22144423_ChIP-Seq_EOC_Human5.99776322
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.91511370
4EGR1_19374776_ChIP-ChIP_THP-1_Human5.68094367
5IGF1R_20145208_ChIP-Seq_DFB_Human4.77309133
6AR_21572438_ChIP-Seq_LNCaP_Human4.75343161
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.55241433
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.48158126
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97856115
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88369710
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72603929
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35300550
13TP53_16413492_ChIP-PET_HCT116_Human2.14531238
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.12153205
15VDR_22108803_ChIP-Seq_LS180_Human2.08144427
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04293344
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.7105280
18YY1_22570637_ChIP-Seq_MALME-3M_Human1.93681583
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91271675
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.90913898
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89601045
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81622609
23GATA1_19941826_ChIP-Seq_K562_Human1.79736792
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75452141
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74693013
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71134975
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66326539
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.65426931
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65354324
30DROSHA_22980978_ChIP-Seq_HELA_Human1.64529399
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.63788118
32ZNF274_21170338_ChIP-Seq_K562_Hela1.62842144
33TAF15_26573619_Chip-Seq_HEK293_Human1.59011161
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58647474
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57285836
36EGR1_19032775_ChIP-ChIP_M12_Human1.55152963
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55101885
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53605143
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.50496060
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.49292717
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48910339
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47411258
43RNF2_27304074_Chip-Seq_NSC_Mouse1.46683394
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45788146
45* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45539644
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45269844
47KDM2B_26808549_Chip-Seq_REH_Human1.43806807
48REST_21632747_ChIP-Seq_MESCs_Mouse1.42403974
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.40981057
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40349868
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39895911
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.38847936
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38837684
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37944818
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.36869901
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36202969
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35099758
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35099758
59STAT1_17558387_ChIP-Seq_HELA_Human1.34659465
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.34107472
61TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30054928
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28829424
63P53_22387025_ChIP-Seq_ESCs_Mouse1.26678528
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23260872
65RXR_22108803_ChIP-Seq_LS180_Human1.23110451
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.22781212
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.22738384
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.22173042
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.21862812
70FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21662426
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20989201
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.20208984
73P300_18555785_Chip-Seq_ESCs_Mouse1.18653348
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17852656
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.17344097
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17295732
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16819664
78CBP_20019798_ChIP-Seq_JUKART_Human1.16819664
79GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.16440277
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.15778782
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.15162915
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14530989
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14373643
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14240816
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.13599859
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.13371829
87KLF4_18555785_Chip-Seq_ESCs_Mouse1.12594320
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12486529
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12264224
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11237680
91GF1_26923725_Chip-Seq_HPCs_Mouse1.10256283
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10152378
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09666504
94ETV1_20927104_ChIP-Seq_GIST48_Human1.08719039
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.08116774
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08025070
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07016579
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06506433
99HNFA_21074721_ChIP-Seq_CACO-2_Human1.06167803
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04853073
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04193460
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04120439
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04045185
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02981924
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02809266
106HTT_18923047_ChIP-ChIP_STHdh_Human1.02796996
107ER_23166858_ChIP-Seq_MCF-7_Human1.02275507
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02275018
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01677202
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.01399986
111BCAT_22108803_ChIP-Seq_LS180_Human1.01293726
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.01100608
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00249908
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.00074900
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99867927
116P53_21459846_ChIP-Seq_SAOS-2_Human0.99851418
117GATA6_21074721_ChIP-Seq_CACO-2_Human0.99801202
118MYC_27129775_Chip-Seq_CORNEA_Mouse0.99463471
119SMAD3_21741376_ChIP-Seq_EPCs_Human0.99267055
120PU1_27457419_Chip-Seq_LIVER_Mouse0.98802686
121GBX2_23144817_ChIP-Seq_PC3_Human0.98681063
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98535364
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.98222168
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97889481
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97521516
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.97177299
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96824035
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.96532673
129TBL1_22424771_ChIP-Seq_293T_Human0.95997701
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.95790165
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95448186
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94982523
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.94912197
134SMAD4_21799915_ChIP-Seq_A2780_Human0.94823824
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94421363
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.94102584
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93147310
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93038696
139SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92443131
140SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92272047
141GATA3_21867929_ChIP-Seq_TH1_Mouse0.92170540
142SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91533246
143CJUN_26792858_Chip-Seq_BT549_Human0.91132916
144PHF8_20622853_ChIP-Seq_HELA_Human0.90808932
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89566605
146STAT3_23295773_ChIP-Seq_U87_Human0.89441578
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88787894
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88452216
149NANOG_16518401_ChIP-PET_MESCs_Mouse0.88385414
150CTCF_27219007_Chip-Seq_Bcells_Human0.88261990
151TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85308716
152EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85244688
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85244688
154CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84499242
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81011165
156KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78280597
157KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78280597
158KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78280597
159RING1B_27294783_Chip-Seq_ESCs_Mouse0.77822189
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76734311
161GATA2_19941826_ChIP-Seq_K562_Human0.76432941
162ISL1_27105846_Chip-Seq_CPCs_Mouse0.75924670
163NANOG_20526341_ChIP-Seq_ESCs_Human0.74826978
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74728281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.71328702
2MP0003698_abnormal_male_reproductive5.30252238
3MP0004130_abnormal_muscle_cell4.96237231
4MP0001929_abnormal_gametogenesis4.49803033
5MP0004264_abnormal_extraembryonic_tissu4.02720172
6MP0008877_abnormal_DNA_methylation3.76896610
7MP0003252_abnormal_bile_duct3.61289531
8MP0002102_abnormal_ear_morphology3.57827133
9MP0004742_abnormal_vestibular_system3.37583350
10MP0005670_abnormal_white_adipose3.23718323
11MP0004133_heterotaxia2.84574252
12MP0002161_abnormal_fertility/fecundity2.80290783
13MP0002928_abnormal_bile_duct2.71705926
14MP0002210_abnormal_sex_determination2.66084816
15MP0001145_abnormal_male_reproductive2.35921821
16MP0005448_abnormal_energy_balance2.30457707
17MP0005408_hypopigmentation2.25889565
18MP0000566_synostosis2.25865801
19MP0002751_abnormal_autonomic_nervous2.24950383
20MP0004272_abnormal_basement_membrane2.16136265
21MP0003329_amyloid_beta_deposits2.14317132
22MP0001270_distended_abdomen2.13132606
23MP0000653_abnormal_sex_gland2.12504336
24MP0005623_abnormal_meninges_morphology2.08674583
25MP0005410_abnormal_fertilization14.1123634
26MP0005084_abnormal_gallbladder_morpholo12.6991951
27MP0000383_abnormal_hair_follicle1.99194116
28MP0003943_abnormal_hepatobiliary_system1.75679204
29MP0005379_endocrine/exocrine_gland_phen1.70779774
30MP0001486_abnormal_startle_reflex1.68173513
31MP0005220_abnormal_exocrine_pancreas1.66011062
32MP0005165_increased_susceptibility_to1.55995616
33MP0009764_decreased_sensitivity_to1.42768014
34MP0001958_emphysema1.41534405
35MP0000604_amyloidosis1.37936605
36MP0010678_abnormal_skin_adnexa1.34764899
37MP0001529_abnormal_vocalization1.33180599
38MP0000647_abnormal_sebaceous_gland1.32489758
39MP0008995_early_reproductive_senescence1.29493441
40MP0002796_impaired_skin_barrier1.29203150
41MP0001765_abnormal_ion_homeostasis1.28904165
42MP0002139_abnormal_hepatobiliary_system1.28880555
43MP0002653_abnormal_ependyma_morphology1.28496884
44MP0001968_abnormal_touch/_nociception1.28233133
45MP0003718_maternal_effect1.22338926
46MP0001963_abnormal_hearing_physiology1.17021948
47MP0002282_abnormal_trachea_morphology1.11856087
48MP0005646_abnormal_pituitary_gland1.08306187
49MP0003938_abnormal_ear_development1.05904812
50MP0005187_abnormal_penis_morphology1.05776634
51MP0002234_abnormal_pharynx_morphology1.03595754
52MP0000026_abnormal_inner_ear1.01758624
53MP0002909_abnormal_adrenal_gland1.01483268
54MP0008058_abnormal_DNA_repair0.99385981
55MP0001944_abnormal_pancreas_morphology0.99273111
56MP0001905_abnormal_dopamine_level0.98625338
57MP0004019_abnormal_vitamin_homeostasis0.96946938
58MP0008569_lethality_at_weaning0.92996771
59MP0005377_hearing/vestibular/ear_phenot0.92293258
60MP0003878_abnormal_ear_physiology0.92293258
61MP0002160_abnormal_reproductive_system0.90511431
62MP0009278_abnormal_bone_marrow0.90175465
63MP0003638_abnormal_response/metabolism_0.89702291
64MP0003121_genomic_imprinting0.82569551
65MP0002098_abnormal_vibrissa_morphology0.81860799
66MP0002272_abnormal_nervous_system0.79915645
67MP0009046_muscle_twitch0.78909689
68MP0001915_intracranial_hemorrhage0.78508758
69MP0005647_abnormal_sex_gland0.77913620
70MP0003942_abnormal_urinary_system0.77874190
71MP0008469_abnormal_protein_level0.77605799
72MP0005164_abnormal_response_to0.77568094
73MP0003385_abnormal_body_wall0.75628089
74MP0000371_diluted_coat_color0.75495717
75MP0003195_calcinosis0.74579623
76MP0003866_abnormal_defecation0.73559913
77MP0001800_abnormal_humoral_immune0.73314206
78MP0009250_abnormal_appendicular_skeleto0.72779230
79MP0002405_respiratory_system_inflammati0.72687279
80MP0000534_abnormal_ureter_morphology0.72334210
81MP0002693_abnormal_pancreas_physiology0.70067513
82MP0000013_abnormal_adipose_tissue0.69586080
83MP0000537_abnormal_urethra_morphology0.69438510
84MP0000609_abnormal_liver_physiology0.69354722
85MP0002067_abnormal_sensory_capabilities0.69279440
86MP0004233_abnormal_muscle_weight0.67833148
87MP0000049_abnormal_middle_ear0.67603502
88MP0008875_abnormal_xenobiotic_pharmacok0.66277166
89MP0001851_eye_inflammation0.65736885
90MP0005636_abnormal_mineral_homeostasis0.65598739
91MP0003787_abnormal_imprinting0.65138826
92MP0000465_gastrointestinal_hemorrhage0.63449879
93MP0002736_abnormal_nociception_after0.63319373
94MP0000703_abnormal_thymus_morphology0.63004320
95MP0006072_abnormal_retinal_apoptosis0.62842577
96MP0002136_abnormal_kidney_physiology0.62620335
97MP0003941_abnormal_skin_development0.62504455
98MP0002078_abnormal_glucose_homeostasis0.61390461
99MP0001790_abnormal_immune_system0.61325668
100MP0005387_immune_system_phenotype0.61325668
101MP0010771_integument_phenotype0.60872614
102MP0005253_abnormal_eye_physiology0.60629088
103MP0003953_abnormal_hormone_level0.60471288
104MP0004947_skin_inflammation0.59831097
105MP0001533_abnormal_skeleton_physiology0.58133434
106MP0010368_abnormal_lymphatic_system0.56770676
107MP0001727_abnormal_embryo_implantation0.56755315
108MP0003959_abnormal_lean_body0.56213528
109MP0002138_abnormal_hepatobiliary_system0.54955411
110MP0005174_abnormal_tail_pigmentation0.54857573
111MP0002998_abnormal_bone_remodeling0.54519118
112MP0001664_abnormal_digestion0.52613868
113MP0008874_decreased_physiological_sensi0.51974443
114MP0004885_abnormal_endolymph0.50717647
115MP0004381_abnormal_hair_follicle0.50703491
116MP0002254_reproductive_system_inflammat0.50058537
117MP0001661_extended_life_span0.50054750
118MP0005551_abnormal_eye_electrophysiolog0.49800113
119MP0000762_abnormal_tongue_morphology0.49634693
120MP0001845_abnormal_inflammatory_respons0.49037197
121MP0000470_abnormal_stomach_morphology0.48570854
122MP0003136_yellow_coat_color0.48564699
123MP0002752_abnormal_somatic_nervous0.47873324
124MP0002060_abnormal_skin_morphology0.47801862
125MP0005501_abnormal_skin_physiology0.47419603
126MP0003786_premature_aging0.46889354
127MP0009642_abnormal_blood_homeostasis0.45628882
128MP0001340_abnormal_eyelid_morphology0.44987044
129MP0002009_preneoplasia0.44978396
130MP0002233_abnormal_nose_morphology0.44976392
131MP0005391_vision/eye_phenotype0.44741139
132MP0005389_reproductive_system_phenotype0.44439288
133MP0002722_abnormal_immune_system0.44337562
134MP0002938_white_spotting0.44232519
135MP0004859_abnormal_synaptic_plasticity0.43544089
136MP0002557_abnormal_social/conspecific_i0.41841837
137MP0002822_catalepsy0.41367964
138MP0001286_abnormal_eye_development0.40661099
139MP0009745_abnormal_behavioral_response0.40634530
140MP0008004_abnormal_stomach_pH0.40447900
141MP0005195_abnormal_posterior_eye0.40238356
142MP0008789_abnormal_olfactory_epithelium0.40144568
143MP0000372_irregular_coat_pigmentation0.39960460
144MP0005334_abnormal_fat_pad0.38990406
145MP0003635_abnormal_synaptic_transmissio0.38959565
146MP0002295_abnormal_pulmonary_circulatio0.38456376
147MP0003115_abnormal_respiratory_system0.38203550
148MP0000477_abnormal_intestine_morphology0.37150546
149MP0000759_abnormal_skeletal_muscle0.37017915
150MP0008260_abnormal_autophagy0.36840331
151MP0001346_abnormal_lacrimal_gland0.36286918
152MP0000920_abnormal_myelination0.35813915
153MP0002429_abnormal_blood_cell0.35627797
154MP0001216_abnormal_epidermal_layer0.35583864
155MP0003861_abnormal_nervous_system0.35564185
156MP0005666_abnormal_adipose_tissue0.35520718
157MP0002419_abnormal_innate_immunity0.35506531
158MP0002116_abnormal_craniofacial_bone0.35441958
159MP0003315_abnormal_perineum_morphology0.35362911
160MP0009931_abnormal_skin_appearance0.35156626
161MP0000598_abnormal_liver_morphology0.35096482
162MP0002572_abnormal_emotion/affect_behav0.34675559
163MP0000467_abnormal_esophagus_morphology0.34511813
164MP0005365_abnormal_bile_salt0.34341906
165MP0004270_analgesia0.33895480
166MP0002882_abnormal_neuron_morphology0.33059087
167MP0004484_altered_response_of0.32064019
168MP0005423_abnormal_somatic_nervous0.31928511
169MP0002452_abnormal_antigen_presenting0.31705499
170MP0005390_skeleton_phenotype0.31484215
171MP0002229_neurodegeneration0.31053524
172MP0001986_abnormal_taste_sensitivity0.30875410
173MP0001299_abnormal_eye_distance/0.29816216
174MP0000716_abnormal_immune_system0.28968111
175MP0005395_other_phenotype0.28703362
176MP0002420_abnormal_adaptive_immunity0.28602689
177MP0001501_abnormal_sleep_pattern0.28275631
178MP0001819_abnormal_immune_cell0.28053981
179MP0002735_abnormal_chemical_nociception0.27821707
180MP0001175_abnormal_lung_morphology0.27367574
181MP0002398_abnormal_bone_marrow0.27074953
182MP0001835_abnormal_antigen_presentation0.25390604
183MP0002723_abnormal_immune_serum0.25280379
184MP0005000_abnormal_immune_tolerance0.23185512
185MP0000689_abnormal_spleen_morphology0.22379054
186MP0002128_abnormal_blood_circulation0.22212788
187MP0002066_abnormal_motor_capabilities/c0.22190143
188MP0009053_abnormal_anal_canal0.21314888
189MP0003634_abnormal_glial_cell0.20832961
190MP0005275_abnormal_skin_tensile0.19160752

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.50987924
2Abnormal respiratory epithelium morphology (HP:0012253)8.37557904
3Abnormal respiratory motile cilium morphology (HP:0005938)8.37557904
4Abnormality of dental color (HP:0011073)8.35176350
5Abnormality of renal resorption (HP:0011038)8.10983589
6Osteomalacia (HP:0002749)7.87789118
7Polyuria (HP:0000103)7.63178875
8Abnormal ciliary motility (HP:0012262)7.04017941
9Abnormal urine output (HP:0012590)6.52953356
10Rhinitis (HP:0012384)6.31977366
11Chronic bronchitis (HP:0004469)6.18272899
12Infertility (HP:0000789)5.57692885
13Round ear (HP:0100830)5.44422719
14Nasal polyposis (HP:0100582)5.27813546
15Abnormality of the nasal mucosa (HP:0000433)4.44090808
16Volvulus (HP:0002580)4.28039407
17IgM deficiency (HP:0002850)4.21504486
18Autoimmune thrombocytopenia (HP:0001973)4.04132779
19Toxemia of pregnancy (HP:0100603)3.95926209
20Nephrocalcinosis (HP:0000121)3.89397858
21Bronchiectasis (HP:0002110)3.87549915
22Esophageal varix (HP:0002040)3.82372779
23Recurrent sinusitis (HP:0011108)3.57678441
24Bronchitis (HP:0012387)3.53075657
25Abnormal spermatogenesis (HP:0008669)3.42050513
26Lipoatrophy (HP:0100578)3.40979463
27Sparse lateral eyebrow (HP:0005338)3.38029939
28Nephronophthisis (HP:0000090)3.37883962
29Depressed nasal tip (HP:0000437)3.33358093
30Male infertility (HP:0003251)3.31598385
31Large earlobe (HP:0009748)3.29260919
32Tachypnea (HP:0002789)3.25161872
33Drooling (HP:0002307)3.18293173
34Hypoparathyroidism (HP:0000829)3.15342706
35Intestinal fistula (HP:0100819)3.15082983
36Excessive salivation (HP:0003781)3.05266052
37Panhypogammaglobulinemia (HP:0003139)2.96200473
38Hyperphosphaturia (HP:0003109)2.88810130
39Personality changes (HP:0000751)2.86711975
40Thick eyebrow (HP:0000574)2.84107458
41Duplicated collecting system (HP:0000081)2.68375860
42Recurrent otitis media (HP:0000403)2.68244092
43Petechiae (HP:0000967)2.65411676
44Abnormality of the renal medulla (HP:0100957)2.57389019
45Azoospermia (HP:0000027)2.55424303
46Ureteral stenosis (HP:0000071)2.54921543
47Dilated cardiomyopathy (HP:0001644)2.53373095
48Hepatitis (HP:0012115)2.51963087
49Short 5th finger (HP:0009237)2.46102535
50Abnormal urine phosphate concentration (HP:0012599)2.45684965
51Abnormality of the fingertips (HP:0001211)2.41641004
52Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.34571743
53Ureteral obstruction (HP:0006000)2.34365940
54Abnormality of urine glucose concentration (HP:0011016)2.33272816
55Glycosuria (HP:0003076)2.33272816
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.33129755
57Parakeratosis (HP:0001036)2.33118872
58J-shaped sella turcica (HP:0002680)2.32376080
59Gingival overgrowth (HP:0000212)2.30395347
60Chronic mucocutaneous candidiasis (HP:0002728)2.30282553
61Recurrent cutaneous fungal infections (HP:0011370)2.30282553
62Sudden cardiac death (HP:0001645)2.28537894
63Abnormality of transition element cation homeostasis (HP:0011030)2.28490022
64Molar tooth sign on MRI (HP:0002419)2.28202850
65Abnormality of midbrain morphology (HP:0002418)2.28202850
66Tubulointerstitial nephritis (HP:0001970)2.28064714
67Striae distensae (HP:0001065)2.26902639
68Hypercalciuria (HP:0002150)2.25410105
69Nephropathy (HP:0000112)2.24599165
70Abnormality of the renal collecting system (HP:0004742)2.23839943
71Periauricular skin pits (HP:0100277)2.22378451
72Preauricular pit (HP:0004467)2.22378451
73Colitis (HP:0002583)2.21586806
74Absent eyebrow (HP:0002223)2.16453494
75Congenital malformation of the right heart (HP:0011723)2.14697710
76Double outlet right ventricle (HP:0001719)2.14697710
77Absent frontal sinuses (HP:0002688)2.14393149
78Decreased muscle mass (HP:0003199)2.14167677
79Cholecystitis (HP:0001082)2.12558851
80Abnormal gallbladder physiology (HP:0012438)2.12558851
81Inability to walk (HP:0002540)2.09882520
82Stage 5 chronic kidney disease (HP:0003774)2.09812648
83Unilateral renal agenesis (HP:0000122)2.08345527
84Anal stenosis (HP:0002025)2.07076507
85Agammaglobulinemia (HP:0004432)2.06956788
86Tubular atrophy (HP:0000092)2.04860689
87Duplication of thumb phalanx (HP:0009942)2.04755233
88Impulsivity (HP:0100710)2.04737742
89Facial cleft (HP:0002006)2.02947940
90Delayed eruption of teeth (HP:0000684)2.02288694
91Abnormality of salivation (HP:0100755)2.00172690
92Absent/shortened dynein arms (HP:0200106)13.0723761
93Dynein arm defect of respiratory motile cilia (HP:0012255)13.0723761
94Overgrowth (HP:0001548)12.3341267
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1180656
96Amelogenesis imperfecta (HP:0000705)11.7185249
97Abnormality of calcium-phosphate metabolism (HP:0100530)10.0994900
98Chondrocalcinosis (HP:0000934)1.95186135
99Deformed sella turcica (HP:0002681)1.94735096
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93100583
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.93100583
102Renal agenesis (HP:0000104)1.92206474
103Abnormality of Sharpey fibers (HP:0100685)1.90424800
104Prominent supraorbital ridges (HP:0000336)1.88651673
105Chorioretinal coloboma (HP:0000567)1.88429942
106Bilateral microphthalmos (HP:0007633)1.87073342
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86778082
108Preauricular skin tag (HP:0000384)1.85663700
109Abnormality of the dental root (HP:0006486)1.83246665
110Taurodontia (HP:0000679)1.83246665
111Abnormality of permanent molar morphology (HP:0011071)1.83246665
112Truncal ataxia (HP:0002078)1.80436953
113Abnormality of molar morphology (HP:0011070)1.80245651
114Abnormality of molar (HP:0011077)1.80245651
115Renal tubular dysfunction (HP:0000124)1.79528956
116Limited elbow extension (HP:0001377)1.77079055
117Recurrent bronchitis (HP:0002837)1.76277496
118Gonadotropin excess (HP:0000837)1.74215972
119Lip pit (HP:0100267)1.71650136
120Ectopic kidney (HP:0000086)1.69363322
121Tubulointerstitial abnormality (HP:0001969)1.66912873
122Reticulocytopenia (HP:0001896)1.65898456
123Villous atrophy (HP:0011473)1.65602928
124Abnormality of small intestinal villus morphology (HP:0011472)1.65602928
125Fibular hypoplasia (HP:0003038)1.65280486
126Abnormality of DNA repair (HP:0003254)1.64918336
127Abnormality of the dental pulp (HP:0006479)1.63494315
128Torticollis (HP:0000473)1.63085416
129Abnormality of the renal cortex (HP:0011035)1.62813228
130Small hand (HP:0200055)1.62020391
131Bell-shaped thorax (HP:0001591)1.61863286
132Chromsome breakage (HP:0040012)1.60667633
133Abnormal biliary tract physiology (HP:0012439)1.59404405
134Bile duct proliferation (HP:0001408)1.59404405
135Upper limb muscle weakness (HP:0003484)1.59392788
136Decreased central vision (HP:0007663)1.59122155
137Morphological abnormality of the middle ear (HP:0008609)1.58897636
138Oculomotor apraxia (HP:0000657)1.58712586
139Mixed hearing impairment (HP:0000410)1.57338608
140Palmoplantar keratoderma (HP:0000982)1.56637376
141Skin tags (HP:0010609)1.56089887
142Ectropion (HP:0000656)1.55999008
143Abnormality of the ileum (HP:0001549)1.54931033
144Blepharitis (HP:0000498)1.54083771
145Meckel diverticulum (HP:0002245)1.53419307
146Polyneuropathy (HP:0001271)1.51788116
147Prenatal maternal abnormality (HP:0002686)1.51651948
148Skin pits (HP:0100276)1.50847308
149Absent thumb (HP:0009777)1.50087316
150Fused cervical vertebrae (HP:0002949)1.48297649
151Abnormality of renal excretion (HP:0011036)1.47846396
152Mask-like facies (HP:0000298)1.46678331
153Renal dysplasia (HP:0000110)1.45669432
154Abnormality of the corticospinal tract (HP:0002492)1.45031958
155Proximal placement of thumb (HP:0009623)1.45019103
156Congenital hepatic fibrosis (HP:0002612)1.43826633
157Abnormality of the preputium (HP:0100587)1.43590865
158Viral hepatitis (HP:0006562)1.42884308
159Osteoarthritis (HP:0002758)1.42793773
16011 pairs of ribs (HP:0000878)1.41074291
161Decreased motor nerve conduction velocity (HP:0003431)1.40903324
162Aplasia/Hypoplasia affecting the retina (HP:0008061)1.39953756
163Highly arched eyebrow (HP:0002553)1.39610625
164Aplasia/Hypoplasia of the macula (HP:0008059)1.39029894
165Cleft eyelid (HP:0000625)1.37720121
166Aplasia/Hypoplasia of the uvula (HP:0010293)1.37051401
167Intestinal atresia (HP:0011100)1.36953221
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.36221958
169Inflammation of the large intestine (HP:0002037)1.35519122
170Polydipsia (HP:0001959)1.34451925
171Abnormal drinking behavior (HP:0030082)1.34451925
172Hypoplasia of dental enamel (HP:0006297)1.33124869
173Potter facies (HP:0002009)1.30682993
174Facial shape deformation (HP:0011334)1.30682993
175Short ribs (HP:0000773)1.28978557
176Male pseudohermaphroditism (HP:0000037)1.28817354
177Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.28806982
178Aplasia/Hypoplasia of the earlobes (HP:0009906)1.28584621
179Macular degeneration (HP:0000608)1.28358589
180Abnormality of the lower motor neuron (HP:0002366)1.23750492
181Congenital stationary night blindness (HP:0007642)1.22395973
182Ureteral duplication (HP:0000073)1.22313536
183Vascular calcification (HP:0004934)1.20957080
184Choroideremia (HP:0001139)1.20739295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.02551709
2PDK38.02551709
3PDK25.07211729
4TESK14.88353165
5PRKD34.16430649
6ICK3.28246941
7PTK2B2.14011748
8STK392.10446180
9BMPR22.10299368
10PNCK1.95906415
11WNK41.94760935
12ADRBK21.71732751
13DYRK1B1.49544693
14STK381.44902936
15NTRK31.42419422
16WNK11.35120829
17HIPK21.24540297
18GRK11.14275597
19NEK21.11977212
20TTK1.02799970
21PDK10.97473386
22PAK60.96850249
23FGFR10.96148478
24MARK10.89857529
25MST1R0.87392092
26ROCK20.80769797
27TYRO30.78699488
28CAMK1G0.77618151
29MAPK150.75633940
30NTRK20.73695574
31PRKCG0.72637697
32MAP2K70.70124438
33TNIK0.69298214
34CLK10.67381949
35DDR20.67161300
36EIF2AK20.66066053
37SYK0.65674164
38RIPK40.62942285
39OBSCN0.59434979
40STK38L0.58919842
41PKN10.58191416
42ROCK10.55218120
43STK30.54170448
44ALK0.53881792
45BMPR1B0.52677041
46PAK20.51651394
47LATS20.51456370
48STK110.51202902
49MAP4K20.50905536
50PINK10.49787992
51IRAK10.48234449
52MKNK20.47301400
53GRK70.45438514
54MAP2K60.45015492
55ABL10.43205103
56PDPK10.42217617
57WNK30.42149987
58MAP3K130.41996430
59TIE10.41887082
60PASK0.41503603
61ATM0.41313229
62PRKAA10.41160228
63TXK0.40474384
64CASK0.39318536
65CHEK10.38982596
66FGFR20.38904232
67PRKCQ0.38262913
68MAP3K40.38076717
69FER0.37732261
70EPHB20.37495276
71CAMK2A0.36140508
72ADRBK10.35790105
73SRPK10.35656836
74LATS10.35259291
75LMTK20.35227929
76PDGFRA0.34936667
77MARK20.34659265
78EPHA40.33765575
79CDC42BPA0.33066710
80ERBB40.32338716
81MATK0.29743471
82PAK30.28764750
83DYRK30.28567709
84PRKCB0.28482326
85PIK3CG0.27127899
86PLK10.25288259
87PRKACG0.25159268
88MAP4K10.25143909
89LYN0.24894828
90PRKAA20.24879789
91MAP2K20.23592554
92PAK10.23130311
93MAPK140.22597295
94GSK3B0.21459039
95EPHA20.19876179
96RPS6KA30.19691310
97KIT0.19661204
98PLK40.19232112
99PRKCZ0.18862400
100GRK50.18759820
101CAMK10.18516574
102TTN0.18486755
103FYN0.17955366
104KDR0.17899577
105PRKACA0.17837136
106INSRR0.17625928
107TLK10.16950127
108SRC0.16193999
109CDK150.15582588
110CSNK1D0.14879175
111CSNK1A10.14711981
112TEC0.14327322
113PRKCA0.14234641
114CDK10.14229241
115MUSK0.14031595
116CHEK20.14008623
117PIM20.14006075
118CHUK0.13978020
119PDGFRB0.13750495
120ITK0.13424838
121KSR10.12445010
122BLK0.12350651
123MAP3K10.11904660
124PRKDC0.11886864
125GRK60.11530877
126PHKG20.11120857
127PHKG10.11120857
128MAPK80.11094825
129CDK180.10918035
130OXSR10.10730533
131RIPK10.10286309
132TNK20.10033967
133MAPK90.09845638
134CSNK1E0.09726561
135TAOK20.09238150
136MTOR0.09164774
137PRKACB0.09159837
138PRKG20.09058032
139LCK0.08546083
140IGF1R0.08427604
141NTRK10.08411397
142CDK11A0.08210457
143CDK50.08104251
144PRKCD0.07817068
145PRKG10.07674433
146PIM10.07196993
147CAMK2G0.06665832
148HCK0.06601274
149BTK0.06537758
150EGFR0.06386970
151AKT10.06170424
152IKBKE0.05097525
153ABL20.04908176
154PIK3CA0.04147870
155PRKCE0.03863772
156MYLK0.03813214
157INSR0.03690561
158CDK30.03329046
159ZAK0.03224748
160TGFBR20.03123594
161CAMK2B0.02901899
162MOS0.02229542
163MAPK40.01308377
164SGK10.01195477

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.97711577
2Sulfur relay system_Homo sapiens_hsa041223.79576618
3Linoleic acid metabolism_Homo sapiens_hsa005913.41521767
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.40726752
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.05636073
6Vitamin B6 metabolism_Homo sapiens_hsa007503.04233860
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.73792651
8Pyruvate metabolism_Homo sapiens_hsa006202.65997142
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.56721759
10Collecting duct acid secretion_Homo sapiens_hsa049662.52329701
11Glucagon signaling pathway_Homo sapiens_hsa049222.44065890
12Vibrio cholerae infection_Homo sapiens_hsa051102.42693241
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33738807
14Propanoate metabolism_Homo sapiens_hsa006402.27787716
15Ether lipid metabolism_Homo sapiens_hsa005652.17275402
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05231725
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.02949002
18Fanconi anemia pathway_Homo sapiens_hsa034601.85619089
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85593669
20Dorso-ventral axis formation_Homo sapiens_hsa043201.80028062
21PPAR signaling pathway_Homo sapiens_hsa033201.75348046
22GABAergic synapse_Homo sapiens_hsa047271.68872084
23Dilated cardiomyopathy_Homo sapiens_hsa054141.66934896
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.64325034
25Amphetamine addiction_Homo sapiens_hsa050311.61696109
26Gap junction_Homo sapiens_hsa045401.54833422
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53151673
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45703701
29Glycerolipid metabolism_Homo sapiens_hsa005611.44680804
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44617605
31Taste transduction_Homo sapiens_hsa047421.38575375
32GnRH signaling pathway_Homo sapiens_hsa049121.37738344
33Ovarian steroidogenesis_Homo sapiens_hsa049131.35682796
34Melanogenesis_Homo sapiens_hsa049161.34286008
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32677165
36Mineral absorption_Homo sapiens_hsa049781.31578257
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30593789
38Renin secretion_Homo sapiens_hsa049241.28294446
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26662538
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.26629675
41Estrogen signaling pathway_Homo sapiens_hsa049151.25331912
42ABC transporters_Homo sapiens_hsa020101.20157523
43Hedgehog signaling pathway_Homo sapiens_hsa043401.19557698
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.18683532
45Platelet activation_Homo sapiens_hsa046111.15008146
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14794689
47Cholinergic synapse_Homo sapiens_hsa047251.14135684
48Arachidonic acid metabolism_Homo sapiens_hsa005901.13322468
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11073430
50Insulin secretion_Homo sapiens_hsa049111.10893773
51Fatty acid metabolism_Homo sapiens_hsa012121.06568337
52Bile secretion_Homo sapiens_hsa049761.05410380
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03389190
54Calcium signaling pathway_Homo sapiens_hsa040201.03095425
55Gastric acid secretion_Homo sapiens_hsa049711.01074059
56Cardiac muscle contraction_Homo sapiens_hsa042600.99644565
57Oocyte meiosis_Homo sapiens_hsa041140.98978355
58Fatty acid degradation_Homo sapiens_hsa000710.96976632
59Circadian rhythm_Homo sapiens_hsa047100.96746275
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91532751
61Selenocompound metabolism_Homo sapiens_hsa004500.89826612
62Inositol phosphate metabolism_Homo sapiens_hsa005620.89637508
63Glutamatergic synapse_Homo sapiens_hsa047240.84804099
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83666828
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82572120
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80190510
67beta-Alanine metabolism_Homo sapiens_hsa004100.79934281
68Basal transcription factors_Homo sapiens_hsa030220.79918400
69Long-term potentiation_Homo sapiens_hsa047200.77753257
70Salivary secretion_Homo sapiens_hsa049700.77610165
71Cocaine addiction_Homo sapiens_hsa050300.76000151
72ECM-receptor interaction_Homo sapiens_hsa045120.74426455
73VEGF signaling pathway_Homo sapiens_hsa043700.73988392
74Morphine addiction_Homo sapiens_hsa050320.73942840
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71603471
76Chemokine signaling pathway_Homo sapiens_hsa040620.70816117
77Chemical carcinogenesis_Homo sapiens_hsa052040.70555155
78cAMP signaling pathway_Homo sapiens_hsa040240.70554000
79Protein digestion and absorption_Homo sapiens_hsa049740.70437512
80Fat digestion and absorption_Homo sapiens_hsa049750.69772929
81Thyroid hormone synthesis_Homo sapiens_hsa049180.69637623
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69212725
83Rheumatoid arthritis_Homo sapiens_hsa053230.68160116
84Phototransduction_Homo sapiens_hsa047440.67844997
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67810443
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.67234026
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66164303
88Phenylalanine metabolism_Homo sapiens_hsa003600.63217344
89Pentose phosphate pathway_Homo sapiens_hsa000300.63149773
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59726746
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57844842
92Axon guidance_Homo sapiens_hsa043600.57627459
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57496675
94Oxytocin signaling pathway_Homo sapiens_hsa049210.55857512
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54743978
96RNA degradation_Homo sapiens_hsa030180.54159589
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53579916
98Olfactory transduction_Homo sapiens_hsa047400.52105204
99Pancreatic secretion_Homo sapiens_hsa049720.51895671
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51780000
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48342050
102Renin-angiotensin system_Homo sapiens_hsa046140.48143333
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48076002
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47747084
105Purine metabolism_Homo sapiens_hsa002300.46017402
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.45285694
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.44655807
108Wnt signaling pathway_Homo sapiens_hsa043100.44388123
109Basal cell carcinoma_Homo sapiens_hsa052170.43411115
110Glutathione metabolism_Homo sapiens_hsa004800.42331004
111Circadian entrainment_Homo sapiens_hsa047130.42028386
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.41616001
113mRNA surveillance pathway_Homo sapiens_hsa030150.39633151
114Alcoholism_Homo sapiens_hsa050340.39568995
115Carbon metabolism_Homo sapiens_hsa012000.38051070
116Fructose and mannose metabolism_Homo sapiens_hsa000510.36920249
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36207579
118Serotonergic synapse_Homo sapiens_hsa047260.35972797
119Parkinsons disease_Homo sapiens_hsa050120.33203052
120Primary immunodeficiency_Homo sapiens_hsa053400.32483989
121Long-term depression_Homo sapiens_hsa047300.31675822
122Staphylococcus aureus infection_Homo sapiens_hsa051500.31070182
123Dopaminergic synapse_Homo sapiens_hsa047280.30175607
124Prion diseases_Homo sapiens_hsa050200.29584951
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28563175
126Complement and coagulation cascades_Homo sapiens_hsa046100.27250483
127Sulfur metabolism_Homo sapiens_hsa009200.26218040
128Rap1 signaling pathway_Homo sapiens_hsa040150.24007050
129Retinol metabolism_Homo sapiens_hsa008300.19885553
130Oxidative phosphorylation_Homo sapiens_hsa001900.17080143
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15326122
132Phagosome_Homo sapiens_hsa041450.14359334
133Systemic lupus erythematosus_Homo sapiens_hsa053220.13331448
134Tuberculosis_Homo sapiens_hsa051520.12136883
135Ras signaling pathway_Homo sapiens_hsa040140.12057791
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.10231443
137HTLV-I infection_Homo sapiens_hsa051660.10067620
138Type I diabetes mellitus_Homo sapiens_hsa049400.09878693
139Caffeine metabolism_Homo sapiens_hsa002320.09680932
140African trypanosomiasis_Homo sapiens_hsa051430.09133006
141Leishmaniasis_Homo sapiens_hsa051400.07534791
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.05443734
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.04859814
144Amoebiasis_Homo sapiens_hsa051460.03495687
145Hematopoietic cell lineage_Homo sapiens_hsa046400.02834410
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.02255774
147Nicotine addiction_Homo sapiens_hsa050330.02165194
148Asthma_Homo sapiens_hsa05310-0.0071474

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