FAM49A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.82180559
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.76588452
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72576110
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65153010
5locomotory exploration behavior (GO:0035641)5.61739586
6regulation of glutamate receptor signaling pathway (GO:1900449)5.33247300
7synaptic vesicle exocytosis (GO:0016079)5.26054413
8synaptic vesicle maturation (GO:0016188)5.22810717
9neuron cell-cell adhesion (GO:0007158)5.18121788
10protein localization to synapse (GO:0035418)5.15359434
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.14743552
12glutamate secretion (GO:0014047)4.92406001
13neurotransmitter-gated ion channel clustering (GO:0072578)4.91927602
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.89383392
15exploration behavior (GO:0035640)4.80030596
16regulation of synaptic vesicle exocytosis (GO:2000300)4.77589541
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.72390281
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60272444
19regulation of synapse structural plasticity (GO:0051823)4.57561806
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39735730
21positive regulation of synapse maturation (GO:0090129)4.37156088
22regulation of synaptic vesicle transport (GO:1902803)4.31812627
23layer formation in cerebral cortex (GO:0021819)4.30535194
24postsynaptic membrane organization (GO:0001941)4.30084666
25glutamate receptor signaling pathway (GO:0007215)4.22997323
26synaptic transmission, glutamatergic (GO:0035249)4.19757413
27regulation of neuronal synaptic plasticity (GO:0048168)4.06853950
28neuron-neuron synaptic transmission (GO:0007270)4.05708013
29neurotransmitter secretion (GO:0007269)4.04827904
30presynaptic membrane assembly (GO:0097105)4.04451599
31macrophage activation involved in immune response (GO:0002281)4.04161461
32positive regulation of gamma-delta T cell activation (GO:0046645)4.02100020
33neuron recognition (GO:0008038)3.97515959
34negative regulation of interleukin-12 production (GO:0032695)3.96100000
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89488739
36response to peptidoglycan (GO:0032494)3.88649952
37proline transport (GO:0015824)3.80344630
38dendritic spine morphogenesis (GO:0060997)3.75257925
39positive regulation of membrane potential (GO:0045838)3.73914312
40regulation of dendritic spine morphogenesis (GO:0061001)3.71659025
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69408538
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.69408538
43modulation by symbiont of host immune response (GO:0052553)3.69408538
44positive regulation by symbiont of host defense response (GO:0052509)3.69408538
45modulation by symbiont of host defense response (GO:0052031)3.69408538
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69408538
47positive regulation of neurotransmitter secretion (GO:0001956)3.67770297
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.65149268
49regulation of postsynaptic membrane potential (GO:0060078)3.64753523
50long-term memory (GO:0007616)3.63962470
51presynaptic membrane organization (GO:0097090)3.63330030
52response to histamine (GO:0034776)3.61694090
53gamma-aminobutyric acid transport (GO:0015812)3.61273231
54long-term synaptic potentiation (GO:0060291)3.61178495
55axonal fasciculation (GO:0007413)3.60433272
56synaptic vesicle endocytosis (GO:0048488)3.60026679
57pyrimidine nucleobase catabolic process (GO:0006208)3.59978899
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57449708
59neutrophil activation involved in immune response (GO:0002283)3.57384875
60regulation of synaptic plasticity (GO:0048167)3.57272891
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56669836
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.53641887
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52056475
64regulation of synapse maturation (GO:0090128)3.49679097
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48719743
66cerebellar granule cell differentiation (GO:0021707)3.47529377
67detection of molecule of bacterial origin (GO:0032490)3.46696635
68dendrite morphogenesis (GO:0048813)3.44705227
69auditory behavior (GO:0031223)3.44523135
70central nervous system projection neuron axonogenesis (GO:0021952)3.44456168
71activation of protein kinase A activity (GO:0034199)3.42160927
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40484765
73neuronal action potential propagation (GO:0019227)3.37094948
74positive regulation of type 2 immune response (GO:0002830)3.32408924
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32056470
76regulation of vesicle fusion (GO:0031338)3.30943307
77behavioral defense response (GO:0002209)3.30742273
78behavioral fear response (GO:0001662)3.30742273
79regulation of neurotransmitter secretion (GO:0046928)3.29705048
80microglial cell activation (GO:0001774)3.28987496
81positive regulation of neurotransmitter transport (GO:0051590)3.26216748
82regulation of dendritic spine development (GO:0060998)3.24967991
83nucleobase catabolic process (GO:0046113)3.21153069
84response to auditory stimulus (GO:0010996)3.18504917
85regulation of T-helper 2 cell differentiation (GO:0045628)3.17300744
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17271513
87clathrin coat assembly (GO:0048268)3.15177441
88positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13799803
89synapse assembly (GO:0007416)3.13245638
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.13001947
91neurotransmitter transport (GO:0006836)3.11897036
92detection of other organism (GO:0098543)3.11606803
93learning (GO:0007612)3.10261869
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09895885
95regulation of female receptivity (GO:0045924)3.08300420
96macrophage activation (GO:0042116)3.07868368
97fear response (GO:0042596)3.04104934
98immunoglobulin mediated immune response (GO:0016064)3.04057697
99granulocyte activation (GO:0036230)3.03892490
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03389670
101germinal center formation (GO:0002467)3.03340734
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02943218
103vesicle transport along microtubule (GO:0047496)3.02408142
104positive regulation of synaptic transmission (GO:0050806)3.01619717
105neutrophil activation (GO:0042119)3.01615811
106cerebral cortex radially oriented cell migration (GO:0021799)3.00881835
107regulation of glutamate secretion (GO:0014048)3.00761269
108T-helper 1 type immune response (GO:0042088)3.00521820
109neuromuscular process controlling balance (GO:0050885)2.97763652
110dopamine receptor signaling pathway (GO:0007212)2.97308059
111transmission of nerve impulse (GO:0019226)2.96853960
112startle response (GO:0001964)2.96742184
113membrane depolarization (GO:0051899)2.96564970
114mechanosensory behavior (GO:0007638)2.95750390
115interferon-gamma-mediated signaling pathway (GO:0060333)2.94376969
116regulation of neurotransmitter transport (GO:0051588)2.94261337
117regulation of synaptic transmission, GABAergic (GO:0032228)2.93395806
118regulation of interferon-beta biosynthetic process (GO:0045357)2.92317287
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92271608
120negative regulation of cell killing (GO:0031342)2.92271608
121regulation of synaptic transmission (GO:0050804)2.91121988
122regulation of T-helper 1 cell differentiation (GO:0045625)2.89611311
123intraspecies interaction between organisms (GO:0051703)2.88569080
124social behavior (GO:0035176)2.88569080
125regulation of neurotransmitter levels (GO:0001505)2.87951066
126adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87475013
127regulation of type 2 immune response (GO:0002828)2.87250532
128neutrophil mediated immunity (GO:0002446)2.85591800
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85235754
130positive regulation of dendritic spine development (GO:0060999)2.85186087
131detection of external biotic stimulus (GO:0098581)2.84404438
132cell migration in hindbrain (GO:0021535)2.83627302
133positive regulation of interleukin-1 beta secretion (GO:0050718)2.82813098
134regulation of B cell receptor signaling pathway (GO:0050855)2.80755594
135myeloid cell activation involved in immune response (GO:0002275)2.80724076
136positive regulation of cellular amide metabolic process (GO:0034250)2.78453890
137negative regulation of T cell mediated immunity (GO:0002710)2.77212050
138defense response to protozoan (GO:0042832)2.77114414
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76357237
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74839260
141positive regulation of mast cell activation (GO:0033005)2.73542148
142detection of bacterium (GO:0016045)2.72254818
143regulation of gamma-delta T cell activation (GO:0046643)2.70195672
144regulation of T cell tolerance induction (GO:0002664)2.68667690
145negative regulation of interleukin-17 production (GO:0032700)2.66107074
146regulation of interleukin-1 beta secretion (GO:0050706)2.65337227
147negative regulation of lymphocyte mediated immunity (GO:0002707)2.63508295
148positive regulation of interleukin-1 secretion (GO:0050716)2.62439143
149type I interferon signaling pathway (GO:0060337)2.62339968
150cellular response to type I interferon (GO:0071357)2.62339968
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.61858373
152positive regulation of mast cell degranulation (GO:0043306)2.61858373
153nerve growth factor signaling pathway (GO:0038180)2.61285680
154negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60737440
155cellular extravasation (GO:0045123)2.59154825
156L-amino acid import (GO:0043092)2.59037134
157response to host immune response (GO:0052572)2.56863320
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56863320
159response to type I interferon (GO:0034340)2.56043857
160myeloid leukocyte mediated immunity (GO:0002444)2.54763926
161detection of biotic stimulus (GO:0009595)2.54054984
162regulation of mast cell degranulation (GO:0043304)2.53508306
163regulation of mast cell activation (GO:0033003)2.53011660
164production of molecular mediator involved in inflammatory response (GO:0002532)2.52847505
165negative regulation of type 2 immune response (GO:0002829)2.49303157
166regulation of tolerance induction (GO:0002643)2.49165484
167response to protozoan (GO:0001562)2.47863259
168response to muramyl dipeptide (GO:0032495)2.46593944
169positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.45495376
170regulation of mast cell activation involved in immune response (GO:0033006)2.45204598
171regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.44655668
172antigen processing and presentation of endogenous antigen (GO:0019883)2.40517250
173negative regulation of leukocyte mediated immunity (GO:0002704)2.40379438
174regulation of interleukin-12 production (GO:0032655)2.40254549
175regulation of regulated secretory pathway (GO:1903305)2.37827402
176regulation of antigen processing and presentation (GO:0002577)2.37701839
177cellular response to nerve growth factor stimulus (GO:1990090)2.36819262
178response to nerve growth factor (GO:1990089)2.36819262
179regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.36050564
180positive regulation of toll-like receptor signaling pathway (GO:0034123)2.35832711
181regulation of interleukin-8 biosynthetic process (GO:0045414)2.35221706
182regulation of T-helper cell differentiation (GO:0045622)2.35217111
183positive regulation of T-helper cell differentiation (GO:0045624)2.34070781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36699571
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.11657172
3GBX2_23144817_ChIP-Seq_PC3_Human3.94378793
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.68208913
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.54296694
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09991702
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96415905
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86602543
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67601147
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.62751089
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62034746
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.59016039
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43344921
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42717446
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42717446
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.39891762
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39260087
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39105560
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37593662
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35732359
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31186290
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.29249963
23DROSHA_22980978_ChIP-Seq_HELA_Human2.26074276
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23106574
25AR_21572438_ChIP-Seq_LNCaP_Human2.20658844
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.12322875
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08914442
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.08053149
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07150870
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.06996773
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06518115
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03117088
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02951270
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02736068
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02707105
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.00303372
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98961160
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96531534
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96388987
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95729200
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90055763
42TAF15_26573619_Chip-Seq_HEK293_Human1.89944708
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86375137
44VDR_24787735_ChIP-Seq_THP-1_Human1.84492462
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82459814
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80964012
47SMAD4_21799915_ChIP-Seq_A2780_Human1.77898100
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75449294
49RUNX_20019798_ChIP-Seq_JUKART_Human1.73581804
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73018593
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71032963
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69976484
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68507992
54P300_19829295_ChIP-Seq_ESCs_Human1.66439628
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63722492
56SPI1_23127762_ChIP-Seq_K562_Human1.61356000
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59762338
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52864843
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48929451
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45866460
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45149198
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.43537443
63* AR_25329375_ChIP-Seq_VCAP_Human1.43533585
64IGF1R_20145208_ChIP-Seq_DFB_Human1.43329611
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43079583
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39737701
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38039474
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37289330
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34960726
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34937689
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33322183
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31600777
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30144252
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.29335075
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29309850
76SCL_19346495_ChIP-Seq_HPC-7_Human1.26726661
77STAT3_23295773_ChIP-Seq_U87_Human1.26083984
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.24186551
79AHR_22903824_ChIP-Seq_MCF-7_Human1.23863540
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23193906
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23136269
82FUS_26573619_Chip-Seq_HEK293_Human1.22728102
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21336820
84* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20976724
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20528853
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20100036
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19960511
88* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19563679
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19454379
90* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18505339
91* AR_19668381_ChIP-Seq_PC3_Human1.17838725
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17265955
93TCF4_23295773_ChIP-Seq_U87_Human1.16754105
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.15829612
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15156251
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.14990298
97ZNF274_21170338_ChIP-Seq_K562_Hela1.14087315
98ER_23166858_ChIP-Seq_MCF-7_Human1.12893747
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.12019444
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11137394
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.10524155
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09989066
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09915379
104RNF2_27304074_Chip-Seq_NSC_Mouse1.09409876
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07873975
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05511257
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05289045
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05216008
109VDR_24763502_ChIP-Seq_THP-1_Human1.04673757
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04470605
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04448478
112* TP53_18474530_ChIP-ChIP_U2OS_Human1.04299753
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03283350
114* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03271978
115* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03271978
116* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03139275
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02709333
118RXR_22108803_ChIP-Seq_LS180_Human1.02679827
119TP53_16413492_ChIP-PET_HCT116_Human1.02475670
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02422478
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.02281236
122EGR1_19032775_ChIP-ChIP_M12_Human1.01880732
123JUN_21703547_ChIP-Seq_K562_Human1.01562010
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01064935
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00794062
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99635120
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98969191
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.98788372
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98145396
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.98102160
131* SMAD3_21741376_ChIP-Seq_HESCs_Human0.97292918
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.96002521
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95989761
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95647574
135* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95411622
136* ERG_21242973_ChIP-ChIP_JURKAT_Human0.95303140
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93838423
138SPI1_23547873_ChIP-Seq_NB4_Human0.93687806
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93310626
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89499317
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88283161
142KDM2B_26808549_Chip-Seq_K562_Human0.88033771
143SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86234451
144GATA3_27048872_Chip-Seq_THYMUS_Human0.86089908
145KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85640012
146KDM2B_26808549_Chip-Seq_DND41_Human0.83702913
147PU_27001747_Chip-Seq_BMDM_Mouse0.82315763
148MYB_26560356_Chip-Seq_TH2_Human0.81123033
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79738750
150SMRT_27268052_Chip-Seq_Bcells_Human0.78973875
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76973420
152* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76834495
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75741025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.82090743
2MP0003880_abnormal_central_pattern5.18579861
3MP0003635_abnormal_synaptic_transmissio4.32391357
4MP0003724_increased_susceptibility_to4.09794607
5MP0004270_analgesia3.80162967
6MP0002063_abnormal_learning/memory/cond3.72094237
7MP0009745_abnormal_behavioral_response3.55019703
8MP0002064_seizures3.13748050
9MP0001968_abnormal_touch/_nociception3.02449233
10MP0002572_abnormal_emotion/affect_behav2.96546138
11MP0006082_CNS_inflammation2.95769222
12MP0009046_muscle_twitch2.93232156
13MP0005423_abnormal_somatic_nervous2.84506169
14MP0001835_abnormal_antigen_presentation2.74607796
15MP0003436_decreased_susceptibility_to2.71073675
16MP0002822_catalepsy2.67875342
17MP0009785_altered_susceptibility_to2.61958725
18MP0002734_abnormal_mechanical_nocicepti2.55446186
19MP0002735_abnormal_chemical_nociception2.46565368
20MP0009780_abnormal_chondrocyte_physiolo2.44940613
21MP0001486_abnormal_startle_reflex2.43167747
22MP0002148_abnormal_hypersensitivity_rea2.41766812
23MP0005671_abnormal_response_to2.41564031
24MP0002736_abnormal_nociception_after2.39783850
25MP0000778_abnormal_nervous_system2.31587801
26MP0001501_abnormal_sleep_pattern2.23631876
27MP0002419_abnormal_innate_immunity2.23172588
28MP0005000_abnormal_immune_tolerance2.21926034
29MP0002272_abnormal_nervous_system2.21823394
30MP0001440_abnormal_grooming_behavior2.13866605
31MP0005025_abnormal_response_to2.04652084
32MP0002733_abnormal_thermal_nociception2.02578010
33MP0000569_abnormal_digit_pigmentation1.98828870
34MP0001790_abnormal_immune_system1.98704916
35MP0005387_immune_system_phenotype1.98704916
36MP0001800_abnormal_humoral_immune1.98203215
37MP0003329_amyloid_beta_deposits1.94554549
38MP0005386_behavior/neurological_phenoty1.91162750
39MP0004924_abnormal_behavior1.91162750
40MP0001970_abnormal_pain_threshold1.89100206
41MP0003787_abnormal_imprinting1.88931578
42MP0002067_abnormal_sensory_capabilities1.87528744
43MP0002184_abnormal_innervation1.87185504
44MP0004811_abnormal_neuron_physiology1.86199647
45MP0002723_abnormal_immune_serum1.85508409
46MP0003879_abnormal_hair_cell1.77701838
47MP0002452_abnormal_antigen_presenting1.77073221
48MP0004858_abnormal_nervous_system1.76945316
49MP0004510_myositis1.76741315
50MP0009764_decreased_sensitivity_to1.75992119
51MP0005167_abnormal_blood-brain_barrier1.74552286
52MP0002557_abnormal_social/conspecific_i1.73870270
53MP0008569_lethality_at_weaning1.67227448
54MP0002420_abnormal_adaptive_immunity1.61310532
55MP0001819_abnormal_immune_cell1.60555027
56MP0000685_abnormal_immune_system1.53311594
57MP0003300_gastrointestinal_ulcer1.52350204
58MP0002332_abnormal_exercise_endurance1.49961146
59MP0001533_abnormal_skeleton_physiology1.47091626
60MP0002909_abnormal_adrenal_gland1.47065473
61MP0004885_abnormal_endolymph1.42082840
62MP0009278_abnormal_bone_marrow1.41057698
63MP0000920_abnormal_myelination1.41004777
64MP0001984_abnormal_olfaction1.39681199
65MP0000955_abnormal_spinal_cord1.38654343
66MP0002066_abnormal_motor_capabilities/c1.38007976
67MP0005646_abnormal_pituitary_gland1.37883000
68MP0001188_hyperpigmentation1.35017012
69MP0005166_decreased_susceptibility_to1.32060665
70MP0002882_abnormal_neuron_morphology1.31141218
71MP0001348_abnormal_lacrimal_gland1.28992757
72MP0006276_abnormal_autonomic_nervous1.27885706
73MP0000604_amyloidosis1.27089712
74MP0008260_abnormal_autophagy1.26703447
75MP0003633_abnormal_nervous_system1.25670883
76MP0001845_abnormal_inflammatory_respons1.24579631
77MP0005058_abnormal_lysosome_morphology1.17832678
78MP0004947_skin_inflammation1.17428573
79MP0000343_altered_response_to1.16636099
80MP0002405_respiratory_system_inflammati1.14956861
81MP0005397_hematopoietic_system_phenotyp1.13245723
82MP0001545_abnormal_hematopoietic_system1.13245723
83MP0004883_abnormal_blood_vessel1.13140022
84MP0002876_abnormal_thyroid_physiology1.10193968
85MP0010155_abnormal_intestine_physiology1.09688836
86MP0002152_abnormal_brain_morphology1.09645339
87MP0000716_abnormal_immune_system1.09136228
88MP0003631_nervous_system_phenotype1.08723269
89MP0001905_abnormal_dopamine_level1.07972760
90MP0008004_abnormal_stomach_pH1.06552725
91MP0000465_gastrointestinal_hemorrhage1.06197659
92MP0001502_abnormal_circadian_rhythm1.03869345
93MP0008469_abnormal_protein_level1.02695134
94MP0003303_peritoneal_inflammation1.00235397
95MP0001529_abnormal_vocalization0.96959314
96MP0005464_abnormal_platelet_physiology0.96440788
97MP0008874_decreased_physiological_sensi0.96389576
98MP0005645_abnormal_hypothalamus_physiol0.96193555
99MP0003828_pulmonary_edema0.94469819
100MP0008872_abnormal_physiological_respon0.92083602
101MP0002398_abnormal_bone_marrow0.91371328
102MP0002998_abnormal_bone_remodeling0.90906333
103MP0003448_altered_tumor_morphology0.88720331
104MP0003191_abnormal_cellular_cholesterol0.87706418
105MP0005164_abnormal_response_to0.86461902
106MP0002069_abnormal_eating/drinking_beha0.86311822
107MP0003183_abnormal_peptide_metabolism0.83539321
108MP0003656_abnormal_erythrocyte_physiolo0.83464052
109MP0002277_abnormal_respiratory_mucosa0.83303458
110MP0005499_abnormal_olfactory_system0.83263394
111MP0005394_taste/olfaction_phenotype0.83263394
112MP0004142_abnormal_muscle_tone0.79524391
113MP0003075_altered_response_to0.78905787
114MP0001853_heart_inflammation0.78585649
115MP0005451_abnormal_body_composition0.78004472
116MP0005535_abnormal_body_temperature0.77508752
117MP0002837_dystrophic_cardiac_calcinosis0.77463731
118MP0001177_atelectasis0.76663972
119MP0004742_abnormal_vestibular_system0.74909174
120MP0004085_abnormal_heartbeat0.73309192
121MP0003634_abnormal_glial_cell0.72224559
122MP0003632_abnormal_nervous_system0.71498294
123MP0001963_abnormal_hearing_physiology0.71382245
124MP0003172_abnormal_lysosome_physiology0.69538806
125MP0001986_abnormal_taste_sensitivity0.69452011
126MP0000689_abnormal_spleen_morphology0.69254509
127MP0002429_abnormal_blood_cell0.67850566
128MP0010386_abnormal_urinary_bladder0.67160150
129MP0003045_fibrosis0.66802280
130MP0000631_abnormal_neuroendocrine_gland0.66629717
131MP0002229_neurodegeneration0.65761590
132MP0004484_altered_response_of0.65035173
133MP0002254_reproductive_system_inflammat0.63950726
134MP0000015_abnormal_ear_pigmentation0.62314898
135MP0003122_maternal_imprinting0.58587011
136MP0004130_abnormal_muscle_cell0.58328399
137MP0002163_abnormal_gland_morphology0.57643434
138MP0002090_abnormal_vision0.57337645
139MP0005310_abnormal_salivary_gland0.56231529
140MP0000751_myopathy0.55578208
141MP0003861_abnormal_nervous_system0.54231794
142MP0005187_abnormal_penis_morphology0.53955949
143MP0002752_abnormal_somatic_nervous0.52721151
144MP0005409_darkened_coat_color0.49701223
145MP0004215_abnormal_myocardial_fiber0.49007859
146MP0002082_postnatal_lethality0.48757698
147MP0010770_preweaning_lethality0.48757698
148MP0010769_abnormal_survival0.48633395
149MP0006292_abnormal_olfactory_placode0.47562235
150MP0003690_abnormal_glial_cell0.47209110
151MP0003956_abnormal_body_size0.45670046
152MP0001943_abnormal_respiration0.45593381
153MP0000681_abnormal_thyroid_gland0.44768574
154MP0010768_mortality/aging0.44630483
155MP0010234_abnormal_vibrissa_follicle0.43657242

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.38195954
2Myokymia (HP:0002411)5.84764151
3Epileptic encephalopathy (HP:0200134)5.63182161
4Focal seizures (HP:0007359)5.36430691
5Hyperventilation (HP:0002883)5.04134875
6Visual hallucinations (HP:0002367)4.76959074
7Optic neuritis (HP:0100653)4.75006358
8Retrobulbar optic neuritis (HP:0100654)4.75006358
9Orchitis (HP:0100796)4.56916703
10Recurrent bacterial skin infections (HP:0005406)4.47870206
11Atonic seizures (HP:0010819)4.35172773
12Febrile seizures (HP:0002373)4.34565069
13Myositis (HP:0100614)4.29945120
14Broad-based gait (HP:0002136)4.29941228
15Eczematoid dermatitis (HP:0000976)4.15990209
16Recurrent abscess formation (HP:0002722)4.15706597
17Abnormality of macrophages (HP:0004311)4.15407089
18Stomatitis (HP:0010280)4.11909765
19Supranuclear gaze palsy (HP:0000605)4.00488716
20Poor eye contact (HP:0000817)3.98005805
21Absence seizures (HP:0002121)3.90387566
22Mutism (HP:0002300)3.78387500
23Progressive cerebellar ataxia (HP:0002073)3.74029660
24Excessive salivation (HP:0003781)3.64931995
25Drooling (HP:0002307)3.64931995
26Dialeptic seizures (HP:0011146)3.58639265
27Abnormality of liposaccharide metabolism (HP:0010968)3.57960261
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.57960261
29Abnormality of glycolipid metabolism (HP:0010969)3.57960261
30Impaired social interactions (HP:0000735)3.50281429
31Abnormal social behavior (HP:0012433)3.50281429
32Generalized tonic-clonic seizures (HP:0002069)3.43113245
33Keratoconjunctivitis sicca (HP:0001097)3.36409116
34Papilledema (HP:0001085)3.32411939
35Amyotrophic lateral sclerosis (HP:0007354)3.31015860
36Urinary bladder sphincter dysfunction (HP:0002839)3.30026604
37Progressive inability to walk (HP:0002505)3.28509689
38Mediastinal lymphadenopathy (HP:0100721)3.26141445
39Recurrent gram-negative bacterial infections (HP:0005420)3.24126822
40Abnormality of binocular vision (HP:0011514)3.19294890
41Diplopia (HP:0000651)3.19294890
42Cerebral inclusion bodies (HP:0100314)3.17558791
43Impaired vibration sensation in the lower limbs (HP:0002166)3.13702728
44Inappropriate behavior (HP:0000719)3.10753697
45Keratoconjunctivitis (HP:0001096)3.09562769
46Neurofibrillary tangles (HP:0002185)3.05339009
47Gaze-evoked nystagmus (HP:0000640)3.02939570
48Inability to walk (HP:0002540)2.96369376
49Amblyopia (HP:0000646)2.96021936
50Truncal ataxia (HP:0002078)2.92953828
51Gastrointestinal infarctions (HP:0005244)2.92225349
52Epileptiform EEG discharges (HP:0011182)2.91629063
53Ankle clonus (HP:0011448)2.91029590
54Abnormal eating behavior (HP:0100738)2.86127930
55Depression (HP:0000716)2.84161100
56Polyphagia (HP:0002591)2.81660725
57Stereotypic behavior (HP:0000733)2.79649236
58Absent speech (HP:0001344)2.79395048
59Action tremor (HP:0002345)2.76742928
60Amyloidosis (HP:0011034)2.76623711
61Abnormality of the corticospinal tract (HP:0002492)2.76560186
62Hemoptysis (HP:0002105)2.76071918
63Recurrent fungal infections (HP:0002841)2.74963397
64Protruding tongue (HP:0010808)2.73882531
65Genetic anticipation (HP:0003743)2.73506725
66Elevated erythrocyte sedimentation rate (HP:0003565)2.73397449
67Akinesia (HP:0002304)2.73088811
68Vasculitis (HP:0002633)2.72581232
69Memory impairment (HP:0002354)2.70954896
70EEG with generalized epileptiform discharges (HP:0011198)2.70684418
71Urinary urgency (HP:0000012)2.69904674
72Postural instability (HP:0002172)2.69334974
73Recurrent skin infections (HP:0001581)2.64249394
74T lymphocytopenia (HP:0005403)2.64136250
75Meningitis (HP:0001287)2.62879638
76Hypsarrhythmia (HP:0002521)2.60627271
77Obstructive lung disease (HP:0006536)2.60601102
78Chronic obstructive pulmonary disease (HP:0006510)2.60601102
79Obstructive sleep apnea (HP:0002870)2.57833951
80Dysdiadochokinesis (HP:0002075)2.57250399
81Impaired smooth pursuit (HP:0007772)2.55626426
82Abnormality of T cell number (HP:0011839)2.55246743
83Limb dystonia (HP:0002451)2.54639123
84Pulmonary infiltrates (HP:0002113)2.53585833
85Encephalitis (HP:0002383)2.52554998
86Anxiety (HP:0000739)2.52241629
87Hemiparesis (HP:0001269)2.51916105
88Torticollis (HP:0000473)2.51212597
89Dysmetria (HP:0001310)2.48806693
90Increased cerebral lipofuscin (HP:0011813)2.48694381
91Bradykinesia (HP:0002067)2.47264388
92Insidious onset (HP:0003587)2.46412687
93Termporal pattern (HP:0011008)2.46412687
94Abnormality of salivation (HP:0100755)2.46306912
95Loss of speech (HP:0002371)2.45543948
96Episodic fever (HP:0001954)2.43723688
97Fetal akinesia sequence (HP:0001989)2.43620833
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42202708
99Vertigo (HP:0002321)2.41468862
100Abnormality of the lower motor neuron (HP:0002366)2.37531822
101Spontaneous hematomas (HP:0007420)2.37228616
102Gangrene (HP:0100758)2.37208168
103Spastic gait (HP:0002064)2.36517541
104Blue irides (HP:0000635)2.35380270
105Chest pain (HP:0100749)2.34010785
106Leukocytosis (HP:0001974)2.32389277
107Gingivitis (HP:0000230)2.29971399
108Dysmetric saccades (HP:0000641)2.28877302
109Autoimmune thrombocytopenia (HP:0001973)2.28764229
110Apathy (HP:0000741)2.27878765
111Urticaria (HP:0001025)2.26787095
112Focal dystonia (HP:0004373)2.25752061
113Dysostosis multiplex (HP:0000943)2.22193776
114Lower limb muscle weakness (HP:0007340)2.18800209
115Pulmonary embolism (HP:0002204)2.17479830
116Abnormality of ocular smooth pursuit (HP:0000617)2.15043576
117Impaired vibratory sensation (HP:0002495)2.13651188
118Lower limb amyotrophy (HP:0007210)2.13409305
119Agnosia (HP:0010524)2.10628256
120Delusions (HP:0000746)2.09623342
121Arterial thrombosis (HP:0004420)2.08642527
122Increased IgM level (HP:0003496)2.06263280
123Megalencephaly (HP:0001355)2.05954598
124Chronic mucocutaneous candidiasis (HP:0002728)2.05903266
125Recurrent cutaneous fungal infections (HP:0011370)2.05903266
126Generalized hypopigmentation of hair (HP:0011358)2.02012308
127Craniofacial dystonia (HP:0012179)2.01819602
128Pheochromocytoma (HP:0002666)1.99818025
129Intellectual disability, severe (HP:0010864)1.99155187
130Diminished motivation (HP:0000745)1.98818137
131Generalized myoclonic seizures (HP:0002123)1.97337986
132Gait imbalance (HP:0002141)1.95838860
133Hepatoblastoma (HP:0002884)1.94521022
134Hemiplegia (HP:0002301)1.93560145
135Abnormality of the pleura (HP:0002103)1.92612271
136Widely spaced teeth (HP:0000687)1.91435925
137Slow saccadic eye movements (HP:0000514)1.91347030
138Recurrent viral infections (HP:0004429)1.91267299
139Sporadic (HP:0003745)1.90805848
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.90170531
141Incomplete penetrance (HP:0003829)1.89857376
142Rapidly progressive (HP:0003678)1.89196890
143Anorexia (HP:0002039)1.87995315
144Scanning speech (HP:0002168)1.86926363
145Intention tremor (HP:0002080)1.86584019
146Sleep apnea (HP:0010535)1.86566876
147Progressive microcephaly (HP:0000253)1.86164590
148Agitation (HP:0000713)1.85753194
149Abnormal hair whorl (HP:0010721)1.85574361
150Eosinophilia (HP:0001880)1.85044195
151Aqueductal stenosis (HP:0002410)1.84588351
152Neuronal loss in central nervous system (HP:0002529)1.83922543
153Increased IgE level (HP:0003212)1.83008607
154Gait ataxia (HP:0002066)1.82398043
155Abnormality of polysaccharide metabolism (HP:0011012)1.82131718
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82131718
157Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82131718
158Palpebral edema (HP:0100540)1.82033717
159Intellectual disability, profound (HP:0002187)1.80867456
160Pachygyria (HP:0001302)1.80613981
161Disinhibition (HP:0000734)1.80106692
162Fair hair (HP:0002286)1.79980440
163Neuroendocrine neoplasm (HP:0100634)1.78041081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.37697834
2EPHA44.31423295
3NTRK33.87937726
4MAP3K93.54501467
5CASK3.41491520
6MAP3K43.00267726
7MAP2K72.91364762
8DAPK22.75944875
9MINK12.47015602
10RIPK42.46937563
11MAP3K122.38821899
12BLK2.36062981
13DAPK12.03592640
14NTRK22.00499824
15PLK21.83980402
16IRAK41.81230188
17CSK1.77987177
18MAP2K41.76501911
19GRK71.74503195
20TYK21.73403288
21KSR11.70991126
22PAK61.69357096
23MAPK131.60077168
24KSR21.59582985
25MAP4K11.58162606
26CDK191.57338975
27CAMKK11.57081463
28SIK21.51225731
29TXK1.50465426
30CDK51.50190412
31MATK1.43479829
32MAP3K131.42321801
33MAP3K111.41536435
34PRPF4B1.29684258
35GRK51.26598047
36CCNB11.25732150
37IKBKE1.24156704
38JAK21.23032803
39PHKG21.20755154
40PHKG11.20755154
41BMPR21.20045103
42JAK11.17755140
43NTRK11.16868455
44IRAK31.16329043
45TNK21.09632696
46TNIK1.08913622
47TBK11.08209941
48JAK31.04816973
49FES1.03538536
50PRKCG1.03301737
51CAMKK21.00755833
52LATS20.99808764
53LYN0.97657510
54ZAP700.97648631
55IRAK20.95998279
56HCK0.95711433
57MAP2K30.93961460
58PKN10.93537012
59EPHA30.93004069
60MAP3K50.91992395
61CAMK2A0.91459345
62RIPK10.90739457
63TAOK20.90605312
64MOS0.90389693
65PRKD30.90327535
66MAP3K30.89746439
67STK110.87101897
68DYRK20.86758418
69RET0.85744494
70ARAF0.85581330
71MAP3K20.84977855
72PTK2B0.84519925
73TAOK30.80594071
74SGK20.80001773
75SGK10.79972126
76EPHB10.78821953
77FGR0.78133476
78CDK180.77578683
79DYRK1A0.76953898
80RAF10.73329143
81CDK150.73115208
82IKBKB0.71217927
83CDK140.71180525
84SGK4940.68615310
85SGK2230.68615310
86SIK30.68578518
87MAP3K60.68419534
88PRKCZ0.68213146
89IRAK10.68203097
90ERBB30.67931433
91CSNK1G20.66179828
92LCK0.65592193
93PRKCE0.65363498
94SGK30.64208151
95CAMK2B0.63685738
96BTK0.63198425
97MAPK120.63068543
98CSF1R0.63018243
99MARK20.61862374
100TYRO30.61274319
101CDK11A0.60886744
102TGFBR20.59305774
103TAOK10.58706545
104DYRK1B0.55986330
105PNCK0.55858358
106PINK10.54821189
107CAMK10.54587327
108YES10.54244768
109OXSR10.52189478
110FYN0.52150725
111STK380.51393683
112BCR0.50765586
113AKT30.49781788
114PDK10.49599493
115SCYL20.49577121
116PRKCQ0.48297355
117PRKCH0.47386987
118INSRR0.47223355
119DAPK30.47088604
120UHMK10.46847855
121MAPK40.46832823
122PAK30.46697280
123MAPK70.46034815
124RPS6KA20.45905709
125MAP3K140.45901853
126MAP2K60.42608377
127SYK0.41597352
128PDPK10.38140566
129RPS6KA30.38065622
130ALK0.36575004
131GRK60.31526303
132CAMK40.28999005
133PRKCB0.28949661
134DMPK0.26375830
135MAPK100.25851386
136MAP2K10.25507115
137STK240.23334611
138TSSK60.22757518
139MAP3K70.21824394
140ADRBK10.21586373
141MAP3K10.20272471
142MAPK80.19935905

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46201952
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02052780
3Olfactory transduction_Homo sapiens_hsa047402.66009183
4Long-term potentiation_Homo sapiens_hsa047202.60683401
5Circadian entrainment_Homo sapiens_hsa047132.58934773
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58492803
7Morphine addiction_Homo sapiens_hsa050322.53415798
8GABAergic synapse_Homo sapiens_hsa047272.43113940
9Glutamatergic synapse_Homo sapiens_hsa047242.41285413
10Amphetamine addiction_Homo sapiens_hsa050312.22944311
11Leishmaniasis_Homo sapiens_hsa051402.18641149
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10009364
13Dopaminergic synapse_Homo sapiens_hsa047282.08300246
14Allograft rejection_Homo sapiens_hsa053302.02961193
15Salivary secretion_Homo sapiens_hsa049701.96842084
16Graft-versus-host disease_Homo sapiens_hsa053321.93111474
17Staphylococcus aureus infection_Homo sapiens_hsa051501.93111239
18Cholinergic synapse_Homo sapiens_hsa047251.82959550
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82216410
20Renin secretion_Homo sapiens_hsa049241.80987984
21Autoimmune thyroid disease_Homo sapiens_hsa053201.76708235
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72310367
23Collecting duct acid secretion_Homo sapiens_hsa049661.65348723
24Gastric acid secretion_Homo sapiens_hsa049711.63816279
25Oxytocin signaling pathway_Homo sapiens_hsa049211.63313454
26Long-term depression_Homo sapiens_hsa047301.62148437
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60677879
28Asthma_Homo sapiens_hsa053101.60198755
29Serotonergic synapse_Homo sapiens_hsa047261.59080806
30Insulin secretion_Homo sapiens_hsa049111.54400696
31Taste transduction_Homo sapiens_hsa047421.53804671
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49275584
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47511274
34Malaria_Homo sapiens_hsa051441.42271978
35Calcium signaling pathway_Homo sapiens_hsa040201.41907272
36Axon guidance_Homo sapiens_hsa043601.41051381
37Cocaine addiction_Homo sapiens_hsa050301.36823170
38GnRH signaling pathway_Homo sapiens_hsa049121.34235513
39Legionellosis_Homo sapiens_hsa051341.33930073
40Pertussis_Homo sapiens_hsa051331.32902009
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31756879
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.30537689
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.28561756
44Gap junction_Homo sapiens_hsa045401.26457877
45TNF signaling pathway_Homo sapiens_hsa046681.25427808
46Glioma_Homo sapiens_hsa052141.20941854
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20732107
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20075716
49Type II diabetes mellitus_Homo sapiens_hsa049301.19869794
50cAMP signaling pathway_Homo sapiens_hsa040241.19312003
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17203884
52Toxoplasmosis_Homo sapiens_hsa051451.14969181
53ErbB signaling pathway_Homo sapiens_hsa040121.14063093
54Estrogen signaling pathway_Homo sapiens_hsa049151.13537324
55Influenza A_Homo sapiens_hsa051641.12729806
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08854425
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06058179
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05193367
59Type I diabetes mellitus_Homo sapiens_hsa049401.00580633
60Viral myocarditis_Homo sapiens_hsa054161.00368828
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99086135
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97398387
63Measles_Homo sapiens_hsa051620.97182527
64Lysosome_Homo sapiens_hsa041420.96456626
65Melanogenesis_Homo sapiens_hsa049160.93112776
66Hematopoietic cell lineage_Homo sapiens_hsa046400.92913187
67Vibrio cholerae infection_Homo sapiens_hsa051100.92318911
68Antigen processing and presentation_Homo sapiens_hsa046120.89922469
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.88639457
70MAPK signaling pathway_Homo sapiens_hsa040100.85980895
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85898331
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.85100908
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.82474608
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81844672
75Primary immunodeficiency_Homo sapiens_hsa053400.79843879
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78088365
77Prion diseases_Homo sapiens_hsa050200.77465459
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76765001
79Chemokine signaling pathway_Homo sapiens_hsa040620.76746739
80African trypanosomiasis_Homo sapiens_hsa051430.76364825
81VEGF signaling pathway_Homo sapiens_hsa043700.76038894
82Dorso-ventral axis formation_Homo sapiens_hsa043200.74475822
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74210192
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73891048
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72143498
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.71495279
87Ras signaling pathway_Homo sapiens_hsa040140.71309455
88Shigellosis_Homo sapiens_hsa051310.69728521
89Hepatitis B_Homo sapiens_hsa051610.69419687
90Hepatitis C_Homo sapiens_hsa051600.69048763
91Choline metabolism in cancer_Homo sapiens_hsa052310.68002927
92Oocyte meiosis_Homo sapiens_hsa041140.67639659
93Endometrial cancer_Homo sapiens_hsa052130.66167088
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65617946
95Dilated cardiomyopathy_Homo sapiens_hsa054140.64884367
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63101947
97Rheumatoid arthritis_Homo sapiens_hsa053230.62761321
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62493559
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61988467
100Colorectal cancer_Homo sapiens_hsa052100.61766361
101Phototransduction_Homo sapiens_hsa047440.61711594
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61252085
103Herpes simplex infection_Homo sapiens_hsa051680.60624067
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.60372057
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60305146
106Acute myeloid leukemia_Homo sapiens_hsa052210.59070154
107Rap1 signaling pathway_Homo sapiens_hsa040150.58993906
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57555446
109Platelet activation_Homo sapiens_hsa046110.57427478
110mTOR signaling pathway_Homo sapiens_hsa041500.56194597
111Renal cell carcinoma_Homo sapiens_hsa052110.55981594
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54861481
113Amoebiasis_Homo sapiens_hsa051460.53690333
114Tuberculosis_Homo sapiens_hsa051520.53381036
115Pancreatic secretion_Homo sapiens_hsa049720.52910633
116Non-small cell lung cancer_Homo sapiens_hsa052230.52214687
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51885869
118Cardiac muscle contraction_Homo sapiens_hsa042600.50808842
119T cell receptor signaling pathway_Homo sapiens_hsa046600.50801302
120Endocytosis_Homo sapiens_hsa041440.48524669
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47405140
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46243710
123B cell receptor signaling pathway_Homo sapiens_hsa046620.46236311
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45715156
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44636054
126Prolactin signaling pathway_Homo sapiens_hsa049170.44058436
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43535306
128Thyroid hormone synthesis_Homo sapiens_hsa049180.42411115
129Osteoclast differentiation_Homo sapiens_hsa043800.42340049
130Insulin signaling pathway_Homo sapiens_hsa049100.41691116
131Salmonella infection_Homo sapiens_hsa051320.40347713
132Alcoholism_Homo sapiens_hsa050340.40303038
133Inositol phosphate metabolism_Homo sapiens_hsa005620.39843705
134Glucagon signaling pathway_Homo sapiens_hsa049220.39755443
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39645821
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38674186
137Phagosome_Homo sapiens_hsa041450.38629476

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