FAM49B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95937966
2negative regulation of cell killing (GO:0031342)5.95937966
3regulation of B cell receptor signaling pathway (GO:0050855)4.78981764
4negative regulation of interleukin-12 production (GO:0032695)4.61607986
5detection of other organism (GO:0098543)4.58109025
6detection of molecule of bacterial origin (GO:0032490)4.37662006
7detection of bacterium (GO:0016045)4.25306790
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20429296
9microglial cell activation (GO:0001774)4.19280330
10detection of external biotic stimulus (GO:0098581)4.04524885
11leukocyte aggregation (GO:0070486)4.03652778
12regulation of gamma-delta T cell activation (GO:0046643)4.00478798
13positive regulation of mast cell activation involved in immune response (GO:0033008)3.93477749
14positive regulation of mast cell degranulation (GO:0043306)3.93477749
15B cell mediated immunity (GO:0019724)3.89240345
16B cell receptor signaling pathway (GO:0050853)3.81204250
17antigen processing and presentation via MHC class Ib (GO:0002475)3.78231761
18response to host immune response (GO:0052572)3.76011700
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.76011700
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58897339
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55241972
22regulation of mast cell degranulation (GO:0043304)3.54683881
23detection of biotic stimulus (GO:0009595)3.53119341
24regulation of mast cell activation (GO:0033003)3.51260650
25locomotory exploration behavior (GO:0035641)3.48723517
26negative regulation of T cell mediated immunity (GO:0002710)3.48048764
27positive regulation of gamma-delta T cell activation (GO:0046645)3.45688907
28regulation of T cell tolerance induction (GO:0002664)3.42955349
29macrophage activation (GO:0042116)3.42879076
30synaptic vesicle maturation (GO:0016188)3.40618776
31regulation of tolerance induction (GO:0002643)3.39439608
32positive regulation of lamellipodium assembly (GO:0010592)3.35343547
33respiratory burst (GO:0045730)3.35189507
34positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.31222917
35regulation of mast cell activation involved in immune response (GO:0033006)3.29739101
36response to host (GO:0075136)3.28181895
37response to host defenses (GO:0052200)3.28181895
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28181895
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27546157
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26501478
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16395811
42regulation of alpha-beta T cell proliferation (GO:0046640)3.15456561
43production of molecular mediator involved in inflammatory response (GO:0002532)3.11220877
44activated T cell proliferation (GO:0050798)3.09390433
45cellular response to interleukin-15 (GO:0071350)3.07669938
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07087771
47response to interleukin-15 (GO:0070672)3.06917702
48mast cell activation (GO:0045576)3.06382843
49positive regulation of leukocyte degranulation (GO:0043302)3.04423963
50negative regulation of phagocytosis (GO:0050765)3.01547721
51positive regulation of interferon-alpha production (GO:0032727)3.00516217
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99318039
53mast cell degranulation (GO:0043303)2.98055503
54mast cell activation involved in immune response (GO:0002279)2.98055503
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96337103
56positive regulation of interleukin-1 beta secretion (GO:0050718)2.96012867
57positive regulation of type 2 immune response (GO:0002830)2.95967301
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95058969
59neutrophil activation involved in immune response (GO:0002283)2.95051379
60positive regulation of antigen processing and presentation (GO:0002579)2.93775430
61regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90957967
62regulation of interferon-alpha production (GO:0032647)2.90226348
63response to muramyl dipeptide (GO:0032495)2.88827234
64regulation of short-term neuronal synaptic plasticity (GO:0048172)2.88318624
65synaptic vesicle exocytosis (GO:0016079)2.87772115
66cellular response to interferon-gamma (GO:0071346)2.86633301
67regulation of antigen processing and presentation (GO:0002577)2.85509015
68positive T cell selection (GO:0043368)2.85309442
69T cell migration (GO:0072678)2.85024080
70modulation by symbiont of host immune response (GO:0052553)2.84830343
71positive regulation by symbiont of host defense response (GO:0052509)2.84830343
72modulation by symbiont of host defense response (GO:0052031)2.84830343
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84830343
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84830343
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.84830343
76negative thymic T cell selection (GO:0045060)2.83375093
77antigen processing and presentation of endogenous antigen (GO:0019883)2.83260850
78neutrophil mediated immunity (GO:0002446)2.82912813
79positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82780070
80regulation of hypersensitivity (GO:0002883)2.81615309
81regulation of B cell differentiation (GO:0045577)2.81583673
82myeloid leukocyte activation (GO:0002274)2.81027105
83negative regulation of B cell proliferation (GO:0030889)2.80767584
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79779672
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78803523
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78803523
87positive regulation of cellular amide metabolic process (GO:0034250)2.78555083
88cellular extravasation (GO:0045123)2.78247190
89regulation of synaptic vesicle exocytosis (GO:2000300)2.78028536
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77386470
91negative T cell selection (GO:0043383)2.77196136
92positive regulation of lamellipodium organization (GO:1902745)2.76953255
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76069855
94regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75759206
95response to protozoan (GO:0001562)2.75634124
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74380861
97Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.70201232
98Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.67425378
99immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.67425378
100Fc-gamma receptor signaling pathway (GO:0038094)2.67425378
101neutrophil activation (GO:0042119)2.66867478
102exploration behavior (GO:0035640)2.66749653
103myeloid cell activation involved in immune response (GO:0002275)2.64360141
104actin nucleation (GO:0045010)2.60271132
105immunoglobulin mediated immune response (GO:0016064)2.58028549
106regulation of glutamate receptor signaling pathway (GO:1900449)2.56093756
107positive regulation of Rap GTPase activity (GO:0032854)2.55653992
108tolerance induction (GO:0002507)2.53533680
109clathrin coat assembly (GO:0048268)2.53140586
110regulation of synapse structural plasticity (GO:0051823)2.52584995
111antigen receptor-mediated signaling pathway (GO:0050851)2.52108172
112granulocyte activation (GO:0036230)2.50234233
113myeloid leukocyte mediated immunity (GO:0002444)2.49787304
114negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.49110719
115ionotropic glutamate receptor signaling pathway (GO:0035235)2.48896859
116immune response-activating cell surface receptor signaling pathway (GO:0002429)2.48382339
117positive regulation of B cell differentiation (GO:0045579)2.48343419
118leukocyte degranulation (GO:0043299)2.48253554
119macrophage activation involved in immune response (GO:0002281)2.47634166
120positive regulation of mast cell activation (GO:0033005)2.47530048
121cellular response to zinc ion (GO:0071294)2.46867193
122regulation of Rap GTPase activity (GO:0032317)2.46088052
123negative regulation of microtubule polymerization (GO:0031115)2.45214046
124regulation of defense response to virus by virus (GO:0050690)2.45114307
125negative regulation of lymphocyte mediated immunity (GO:0002707)2.41405959
126negative regulation of leukocyte mediated immunity (GO:0002704)2.37878566
127interferon-gamma production (GO:0032609)2.37708363
128regulation of synaptic vesicle transport (GO:1902803)2.36939370
129T cell costimulation (GO:0031295)2.36818591
130interferon-gamma-mediated signaling pathway (GO:0060333)2.36660176
131response to fungus (GO:0009620)2.36558560
132regulation of gamma-delta T cell differentiation (GO:0045586)2.35830150
133positive thymic T cell selection (GO:0045059)2.35473867
134defense response to protozoan (GO:0042832)2.33848481
135lymphocyte costimulation (GO:0031294)2.33705257
136response to peptidoglycan (GO:0032494)2.33415337
137mature B cell differentiation (GO:0002335)2.32859554
138positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30491946
139regulation of regulated secretory pathway (GO:1903305)2.30108564
140negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.27705813
141regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.27554928
142positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.27554928
143T cell homeostasis (GO:0043029)2.26752308
144myeloid dendritic cell activation (GO:0001773)2.25913503
145regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25023422
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24615297
147neutrophil chemotaxis (GO:0030593)2.23268724
148leukocyte cell-cell adhesion (GO:0007159)2.22536353
149regulation of leukocyte degranulation (GO:0043300)2.22236840
150glutamate secretion (GO:0014047)2.21061013
151regulation of interferon-beta biosynthetic process (GO:0045357)2.20842566
152neuron cell-cell adhesion (GO:0007158)2.20551104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06990891
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.92419140
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.79642146
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.76642562
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.66626734
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54383779
7MYC_22102868_ChIP-Seq_BL_Human3.37410164
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92293510
9VDR_21846776_ChIP-Seq_THP-1_Human2.85443149
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83225977
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.69239073
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65310752
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61465431
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60058912
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.59707491
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51361706
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45336981
18RUNX_20019798_ChIP-Seq_JUKART_Human2.45197196
19MYB_26560356_Chip-Seq_TH2_Human2.34577266
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30058236
21SCL_19346495_ChIP-Seq_HPC-7_Human2.29644242
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.28972311
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.28504497
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25054172
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24631514
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20142570
27* SPI1_23547873_ChIP-Seq_NB4_Human2.19715816
28MAF_26560356_Chip-Seq_TH1_Human2.19416463
29VDR_24763502_ChIP-Seq_THP-1_Human2.18709484
30EZH2_22144423_ChIP-Seq_EOC_Human2.18126020
31SPI1_23127762_ChIP-Seq_K562_Human2.16473438
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13719186
33IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11409365
34TCF7_22412390_ChIP-Seq_EML_Mouse2.10517579
35UTX_26944678_Chip-Seq_JUKART_Human2.02504033
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.96923606
37KDM2B_26808549_Chip-Seq_DND41_Human1.95258009
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94611107
39* RUNX1_22412390_ChIP-Seq_EML_Mouse1.92791110
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91548100
41* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88062259
42MYB_26560356_Chip-Seq_TH1_Human1.82977306
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81663657
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81107036
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80005239
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78299757
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77595783
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76716948
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73769311
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69374682
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68858007
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53587379
53* VDR_23849224_ChIP-Seq_CD4+_Human1.51577683
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.40786570
55* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40579595
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34348274
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31942156
58MAF_26560356_Chip-Seq_TH2_Human1.30390748
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29464952
60* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28775941
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25863445
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24675325
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24415814
64* TFEB_21752829_ChIP-Seq_HELA_Human1.24036781
65PU_27001747_Chip-Seq_BMDM_Mouse1.23348262
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.23012613
67FOXP3_21729870_ChIP-Seq_TREG_Human1.21984769
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21371058
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.19750060
70GATA1_22025678_ChIP-Seq_K562_Human1.18428855
71REST_21632747_ChIP-Seq_MESCs_Mouse1.18176224
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15634155
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13899375
74* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11761064
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.11564604
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11291575
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11147179
78* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09850866
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09628466
80* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08321831
81* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08109189
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.07038736
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05987979
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04293361
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03907276
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03683848
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02800968
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02485041
89* CIITA_25753668_ChIP-Seq_RAJI_Human1.01620763
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00785259
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98470806
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98445407
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97275347
94DROSHA_22980978_ChIP-Seq_HELA_Human0.93629039
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91040364
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88289754
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88215147
98GATA3_26560356_Chip-Seq_TH2_Human0.87952784
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.87697036
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86811407
101SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84764868
102GATA3_26560356_Chip-Seq_TH1_Human0.84062491
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83831629
104AR_21572438_ChIP-Seq_LNCaP_Human0.83072733
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82013108
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.81377684
107ELK1_19687146_ChIP-ChIP_HELA_Human0.81335009
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81235439
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81035683
110VDR_24787735_ChIP-Seq_THP-1_Human0.80558587
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.79921546
112LXR_22292898_ChIP-Seq_THP-1_Human0.79455288
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79225471
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78976685
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77641007
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77261095
117* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77121108
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76314275
119ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76261359
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.76157664
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76078403
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.75933020
123* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75388699
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75235451
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75153312
126SALL4_22934838_ChIP-ChIP_CD34+_Human0.74261755
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.73863386
128PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71655932
129* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71300799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.71727643
2MP0003303_peritoneal_inflammation3.62622369
3MP0001835_abnormal_antigen_presentation3.09607117
4MP0005671_abnormal_response_to2.75694012
5MP0003880_abnormal_central_pattern2.62520139
6MP0003635_abnormal_synaptic_transmissio2.34822479
7MP0001800_abnormal_humoral_immune2.30418297
8MP0005000_abnormal_immune_tolerance2.26996446
9MP0002420_abnormal_adaptive_immunity2.14524114
10MP0002452_abnormal_antigen_presenting2.12419211
11MP0001819_abnormal_immune_cell2.11969367
12MP0003436_decreased_susceptibility_to2.11331522
13MP0000685_abnormal_immune_system2.07876482
14MP0008260_abnormal_autophagy2.06033937
15MP0001790_abnormal_immune_system2.05891273
16MP0005387_immune_system_phenotype2.05891273
17MP0002723_abnormal_immune_serum2.02076380
18MP0002398_abnormal_bone_marrow1.97773043
19MP0003172_abnormal_lysosome_physiology1.97028499
20MP0002419_abnormal_innate_immunity1.94852376
21MP0009745_abnormal_behavioral_response1.89874176
22MP0004510_myositis1.88511166
23MP0002064_seizures1.86669637
24MP0009785_altered_susceptibility_to1.86481011
25MP0002063_abnormal_learning/memory/cond1.84406324
26MP0005025_abnormal_response_to1.83948212
27MP0009764_decreased_sensitivity_to1.80813192
28MP0002148_abnormal_hypersensitivity_rea1.74757528
29MP0000716_abnormal_immune_system1.73854253
30MP0003763_abnormal_thymus_physiology1.69417323
31MP0005451_abnormal_body_composition1.69128463
32MP0003183_abnormal_peptide_metabolism1.65107832
33MP0006082_CNS_inflammation1.60249230
34MP0001968_abnormal_touch/_nociception1.59917566
35MP0009046_muscle_twitch1.57400946
36MP0000569_abnormal_digit_pigmentation1.57400637
37MP0002396_abnormal_hematopoietic_system1.55828792
38MP0005464_abnormal_platelet_physiology1.54493840
39MP0005423_abnormal_somatic_nervous1.54332647
40MP0003300_gastrointestinal_ulcer1.52823378
41MP0003191_abnormal_cellular_cholesterol1.51360025
42MP0000689_abnormal_spleen_morphology1.50365892
43MP0002572_abnormal_emotion/affect_behav1.47556292
44MP0002722_abnormal_immune_system1.46162668
45MP0002405_respiratory_system_inflammati1.45857162
46MP0003329_amyloid_beta_deposits1.43322529
47MP0005174_abnormal_tail_pigmentation1.43160524
48MP0008469_abnormal_protein_level1.42254052
49MP0002429_abnormal_blood_cell1.40547673
50MP0000703_abnormal_thymus_morphology1.39221296
51MP0003221_abnormal_cardiomyocyte_apopto1.36982525
52MP0004270_analgesia1.34241971
53MP0003806_abnormal_nucleotide_metabolis1.32782307
54MP0004808_abnormal_hematopoietic_stem1.27619205
55MP0003075_altered_response_to1.27576045
56MP0003866_abnormal_defecation1.27242530
57MP0002166_altered_tumor_susceptibility1.26691266
58MP0000604_amyloidosis1.24605297
59MP0008569_lethality_at_weaning1.21981457
60MP0005310_abnormal_salivary_gland1.20437511
61MP0003828_pulmonary_edema1.19603865
62MP0002736_abnormal_nociception_after1.19305028
63MP0002009_preneoplasia1.18960061
64MP0009333_abnormal_splenocyte_physiolog1.18156236
65MP0008057_abnormal_DNA_replication1.17177430
66MP0000465_gastrointestinal_hemorrhage1.15887386
67MP0001486_abnormal_startle_reflex1.15518122
68MP0004811_abnormal_neuron_physiology1.15257840
69MP0002735_abnormal_chemical_nociception1.14641037
70MP0001970_abnormal_pain_threshold1.13169169
71MP0002733_abnormal_thermal_nociception1.11537299
72MP0002272_abnormal_nervous_system1.11448339
73MP0002006_tumorigenesis1.09313959
74MP0003787_abnormal_imprinting1.07894717
75MP0005075_abnormal_melanosome_morpholog1.07840875
76MP0004883_abnormal_blood_vessel1.06797814
77MP0001845_abnormal_inflammatory_respons1.06684105
78MP0001851_eye_inflammation1.06141846
79MP0001501_abnormal_sleep_pattern1.06076338
80MP0004381_abnormal_hair_follicle1.05913867
81MP0000015_abnormal_ear_pigmentation1.05504488
82MP0010155_abnormal_intestine_physiology1.03682223
83MP0005058_abnormal_lysosome_morphology1.03599433
84MP0009278_abnormal_bone_marrow1.01599382
85MP0002132_abnormal_respiratory_system1.01564035
86MP0001853_heart_inflammation1.01098697
87MP0010307_abnormal_tumor_latency1.01067497
88MP0003448_altered_tumor_morphology1.00505041
89MP0001873_stomach_inflammation0.99480722
90MP0003656_abnormal_erythrocyte_physiolo0.98954830
91MP0003633_abnormal_nervous_system0.98472769
92MP0000920_abnormal_myelination0.97982957
93MP0000343_altered_response_to0.97209959
94MP0009763_increased_sensitivity_to0.94774056
95MP0001533_abnormal_skeleton_physiology0.93465565
96MP0002067_abnormal_sensory_capabilities0.93410883
97MP0001440_abnormal_grooming_behavior0.92670487
98MP0004924_abnormal_behavior0.92640214
99MP0005386_behavior/neurological_phenoty0.92640214
100MP0002734_abnormal_mechanical_nocicepti0.90635143
101MP0003690_abnormal_glial_cell0.90609096
102MP0002277_abnormal_respiratory_mucosa0.90575676
103MP0005076_abnormal_cell_differentiation0.90092587
104MP0005166_decreased_susceptibility_to0.89904714
105MP0001545_abnormal_hematopoietic_system0.88616569
106MP0005397_hematopoietic_system_phenotyp0.88616569
107MP0002998_abnormal_bone_remodeling0.86260209
108MP0000858_altered_metastatic_potential0.83024788
109MP0002019_abnormal_tumor_incidence0.82888729
110MP0000490_abnormal_crypts_of0.81195382
111MP0002822_catalepsy0.78238509
112MP0010094_abnormal_chromosome_stability0.78193761
113MP0008874_decreased_physiological_sensi0.78135971
114MP0009765_abnormal_xenobiotic_induced0.77836038
115MP0001529_abnormal_vocalization0.76735931
116MP0004947_skin_inflammation0.75574706
117MP0003631_nervous_system_phenotype0.74781735
118MP0008961_abnormal_basal_metabolism0.73665637
119MP0002557_abnormal_social/conspecific_i0.73503448
120MP0002877_abnormal_melanocyte_morpholog0.72361558
121MP0006035_abnormal_mitochondrial_morpho0.70685463
122MP0003724_increased_susceptibility_to0.70525287
123MP0002332_abnormal_exercise_endurance0.69097067
124MP0008873_increased_physiological_sensi0.66710649
125MP0005164_abnormal_response_to0.66028596
126MP0008007_abnormal_cellular_replicative0.63898342
127MP0005167_abnormal_blood-brain_barrier0.61932293
128MP0000313_abnormal_cell_death0.57883212
129MP0008877_abnormal_DNA_methylation0.54094580
130MP0001663_abnormal_digestive_system0.53351309
131MP0001986_abnormal_taste_sensitivity0.52239358
132MP0008058_abnormal_DNA_repair0.51292281
133MP0006036_abnormal_mitochondrial_physio0.47611352
134MP0003795_abnormal_bone_structure0.46880860
135MP0005319_abnormal_enzyme/_coenzyme0.46356263

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.81088527
2Optic neuritis (HP:0100653)4.70052834
3Retrobulbar optic neuritis (HP:0100654)4.70052834
4Orchitis (HP:0100796)4.56839392
5Papilledema (HP:0001085)4.51352543
6Eczematoid dermatitis (HP:0000976)4.30967758
7Recurrent bacterial skin infections (HP:0005406)4.12305043
8Chronic obstructive pulmonary disease (HP:0006510)3.82506718
9Obstructive lung disease (HP:0006536)3.82506718
10Encephalitis (HP:0002383)3.74520066
11Gastrointestinal infarctions (HP:0005244)3.58865000
12Keratoconjunctivitis sicca (HP:0001097)3.58178844
13Mediastinal lymphadenopathy (HP:0100721)3.40227910
14Urticaria (HP:0001025)3.29015885
15Keratoconjunctivitis (HP:0001096)3.27667523
16Focal motor seizures (HP:0011153)3.24542225
17Visual hallucinations (HP:0002367)3.23845519
18Recurrent fungal infections (HP:0002841)3.19572108
19Disinhibition (HP:0000734)3.13544174
20Chronic otitis media (HP:0000389)3.12893740
21Cellulitis (HP:0100658)3.03049751
22Recurrent viral infections (HP:0004429)3.01684641
23Meningitis (HP:0001287)2.98169107
24Mutism (HP:0002300)2.94232335
25Stomatitis (HP:0010280)2.93933424
26Inappropriate behavior (HP:0000719)2.93635001
27Amyotrophic lateral sclerosis (HP:0007354)2.92842774
28Apathy (HP:0000741)2.91719603
29Diminished motivation (HP:0000745)2.88921975
30Elevated erythrocyte sedimentation rate (HP:0003565)2.87243760
31Increased IgM level (HP:0003496)2.86785008
32Abnormality of binocular vision (HP:0011514)2.86624771
33Diplopia (HP:0000651)2.86624771
34Agnosia (HP:0010524)2.86154909
35IgM deficiency (HP:0002850)2.82481868
36Recurrent skin infections (HP:0001581)2.75813377
37Arterial thrombosis (HP:0004420)2.69571667
38Chronic mucocutaneous candidiasis (HP:0002728)2.67413799
39Recurrent cutaneous fungal infections (HP:0011370)2.67413799
40Anorexia (HP:0002039)2.66843890
41Myositis (HP:0100614)2.65477682
42Abnormality of macrophages (HP:0004311)2.63154996
43Gangrene (HP:0100758)2.61518768
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.61461396
45Focal seizures (HP:0007359)2.61333483
46Acute hepatic failure (HP:0006554)2.60560457
47Granulocytopenia (HP:0001913)2.58246600
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57608546
49Increased cerebral lipofuscin (HP:0011813)2.57327187
50Abnormality of the prostate (HP:0008775)2.55969535
51Myokymia (HP:0002411)2.54795809
52Recurrent gram-negative bacterial infections (HP:0005420)2.50976609
53Autoimmune thrombocytopenia (HP:0001973)2.48178341
54Autoimmune hemolytic anemia (HP:0001890)2.46806056
55Pulmonary embolism (HP:0002204)2.46579494
56Panhypogammaglobulinemia (HP:0003139)2.42707969
57Amyloidosis (HP:0011034)2.41928388
58Abnormality of the pleura (HP:0002103)2.41679607
59Severe combined immunodeficiency (HP:0004430)2.39058390
60Thrombocytosis (HP:0001894)2.36488717
61Chest pain (HP:0100749)2.35053276
62Pustule (HP:0200039)2.33667981
63Supranuclear gaze palsy (HP:0000605)2.33657660
64Atonic seizures (HP:0010819)2.33462983
65Recurrent bronchitis (HP:0002837)2.32559391
66Combined immunodeficiency (HP:0005387)2.31481665
67Amaurosis fugax (HP:0100576)2.31263791
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.29141602
69Agammaglobulinemia (HP:0004432)2.28886033
70Inflammation of the large intestine (HP:0002037)2.27537239
71Gastrointestinal inflammation (HP:0004386)2.25252129
72Glomerulopathy (HP:0100820)2.24786131
73Polyneuropathy (HP:0001271)2.22188444
74T lymphocytopenia (HP:0005403)2.20883270
75Gingival bleeding (HP:0000225)2.19888827
76Papilloma (HP:0012740)2.19296118
77Verrucae (HP:0200043)2.19296118
78Abnormality of eosinophils (HP:0001879)2.18609576
79Keratitis (HP:0000491)2.16172582
80Vasculitis (HP:0002633)2.13369740
81Abnormality of T cells (HP:0002843)2.13095450
82Fatigue (HP:0012378)2.12931565
83Increased IgE level (HP:0003212)2.11993068
84Episodic fever (HP:0001954)2.11462112
85Loss of speech (HP:0002371)2.11251737
86Epistaxis (HP:0000421)2.10200035
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08666134
88Thyroiditis (HP:0100646)2.07818270
89Abnormality of T cell number (HP:0011839)2.06830488
90Stereotypic behavior (HP:0000733)2.05379175
91Progressive inability to walk (HP:0002505)2.04624996
92Annular pancreas (HP:0001734)2.03968935
93Skin rash (HP:0000988)2.03017778
94Hemiplegia (HP:0002301)2.02332766
95Hypochromic microcytic anemia (HP:0004840)2.00715636
96Gingivitis (HP:0000230)2.00647426
97Petechiae (HP:0000967)1.99203409
98Absence seizures (HP:0002121)1.98535361
99Neuronal loss in central nervous system (HP:0002529)1.97259887
100Absent frontal sinuses (HP:0002688)1.97058515
101Vertigo (HP:0002321)1.96978879
102Epileptic encephalopathy (HP:0200134)1.95995109
103Depression (HP:0000716)1.93684419
104Skin ulcer (HP:0200042)1.92055918
105Lymphopenia (HP:0001888)1.91882404
106Impaired smooth pursuit (HP:0007772)1.91590940
107Colitis (HP:0002583)1.91340894
108Urinary urgency (HP:0000012)1.91004023
109Truncal ataxia (HP:0002078)1.90142922
110Hepatosplenomegaly (HP:0001433)1.87780862
111Abnormality of T cell physiology (HP:0011840)1.87116518
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.87111235
113Poor eye contact (HP:0000817)1.86972432
114Memory impairment (HP:0002354)1.86860966
115Prolonged bleeding time (HP:0003010)1.86805598
116Abnormality of oral frenula (HP:0000190)1.86643239
117Dialeptic seizures (HP:0011146)1.86329076
118Abnormality of B cell number (HP:0010975)1.86260165
119B lymphocytopenia (HP:0010976)1.86260165
120Neoplasm of the tracheobronchial system (HP:0100552)1.85739771
121Broad-based gait (HP:0002136)1.85129162
122Lymphoma (HP:0002665)1.84456220
123Pointed chin (HP:0000307)1.84138991
124Atrophy/Degeneration involving motor neurons (HP:0007373)1.83666132
125Viral hepatitis (HP:0006562)1.83379138
126Spontaneous hematomas (HP:0007420)1.83107710
127IgG deficiency (HP:0004315)1.82712776
128Abnormality of liposaccharide metabolism (HP:0010968)1.81386166
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.81386166
130Abnormality of glycolipid metabolism (HP:0010969)1.81386166
131Dysostosis multiplex (HP:0000943)1.78605817
132Cerebral inclusion bodies (HP:0100314)1.78169583
133Increased density of long bones (HP:0006392)1.74342396
134Gastrointestinal stroma tumor (HP:0100723)1.73350725
135Eosinophilia (HP:0001880)1.73232847
136Sepsis (HP:0100806)1.70551122
137Urinary bladder sphincter dysfunction (HP:0002839)1.70352413
138Leukocytosis (HP:0001974)1.69967490
139Ankyloglossia (HP:0010296)1.69401832
140Pulmonary infiltrates (HP:0002113)1.68539432
141Interstitial pulmonary disease (HP:0006530)1.68210677
142Osteomyelitis (HP:0002754)1.67964830
143Hemoptysis (HP:0002105)1.67605617
144Basal cell carcinoma (HP:0002671)1.67570393
145Resting tremor (HP:0002322)1.66648549
146Nasal polyposis (HP:0100582)1.65646801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.11300451
2MAP3K93.30027970
3MAP4K13.23247927
4FES3.01069501
5GRK62.44319315
6MAP3K122.34606656
7SCYL22.16786474
8BLK2.14417646
9SIK32.08588808
10SIK22.00705560
11NTRK31.93853403
12MAP2K31.83244376
13IRAK41.80699962
14CDK191.79058891
15EPHA41.74823430
16MAP3K131.72642918
17SYK1.71899910
18FGR1.69552607
19ALK1.67797531
20KSR21.66749181
21CSF1R1.64960790
22MARK11.60706043
23CAMKK11.59569342
24MINK11.56968756
25TAOK31.56073288
26TXK1.55410313
27DAPK11.52736092
28TESK21.52114436
29ZAP701.38956469
30RPS6KA41.37009657
31CLK11.33529063
32HCK1.32531654
33BTK1.30098056
34YES11.29510210
35CSK1.25412415
36ITK1.24593198
37ERBB31.22431506
38EEF2K1.22031507
39PRPF4B1.21176393
40MAP3K41.18507877
41PKN21.17578497
42IKBKB1.14962773
43STK101.14327050
44KIT1.12700355
45LCK1.07519584
46CAMKK21.07088630
47DAPK21.03223284
48PAK61.02535580
49JAK31.01762851
50NTRK21.01159799
51MAP3K100.99306687
52TNK20.97373956
53TYK20.95888162
54CDC70.95304884
55TRIM280.93913042
56TEC0.92567659
57KSR10.92501246
58RAF10.91949409
59PDK10.91467664
60MAP3K50.89896225
61LYN0.88772201
62UHMK10.88770269
63CDK50.87748507
64MAP2K70.87579687
65IRAK20.86171533
66STK110.85993692
67TAOK20.83757442
68JAK10.83711779
69PNCK0.82950200
70TYRO30.80519352
71ACVR1B0.79870285
72TAOK10.78592684
73LRRK20.77747310
74CCNB10.76156529
75MARK30.76149163
76MAP3K10.73713449
77MAP3K110.73119831
78FYN0.72401463
79CDK60.71735420
80MAP3K30.71050331
81TBK10.68990671
82CDK150.68920135
83CDK180.67974484
84SRPK10.66206283
85CDK11A0.65732436
86IRAK10.65692282
87TESK10.63763707
88CDK140.63509703
89RET0.63174053
90MAP3K60.61600603
91DMPK0.60791368
92KDR0.60785368
93PRKCH0.60520850
94MATK0.57242667
95PLK20.56246466
96DYRK30.55742716
97TRIB30.55456893
98PIM10.55215941
99PIK3CG0.55186382
100MAP4K20.54262661
101EPHB10.54216077
102IRAK30.54170678
103GRK70.53280871
104JAK20.53245852
105NTRK10.52271491
106MAP2K40.51950529
107PRKCQ0.51588738
108EIF2AK30.50700221
109FLT30.49694416
110BCR0.47224520
111CDK40.46992129
112MAP3K80.46652701
113TSSK60.46594921
114PDPK10.46309924
115PAK40.46252466
116MAP3K140.45995286
117MAP3K20.45370702
118LIMK10.45076310
119IKBKE0.44162522
120STK160.41816744
121MAPK130.41187612
122ARAF0.40510700
123MAPK40.39574300
124ABL10.38948507
125ERN10.37450812
126HIPK20.36611993
127CSNK1G20.35554701
128EGFR0.34632041
129BMPR20.34604102
130TGFBR20.32662979
131FGFR30.32285899
132PRKCD0.31223713
133MAPK120.30442902
134MST40.29765861
135OXSR10.29440324
136RPS6KA20.29139620
137IGF1R0.26117930
138NEK60.22871092
139STK240.19937315
140TRPM70.19616236
141MAP2K60.19550603

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.33469428
2Staphylococcus aureus infection_Homo sapiens_hsa051502.90677648
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01730630
4Rheumatoid arthritis_Homo sapiens_hsa053231.98500852
5B cell receptor signaling pathway_Homo sapiens_hsa046621.96515124
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89067781
7Legionellosis_Homo sapiens_hsa051341.88516077
8Long-term potentiation_Homo sapiens_hsa047201.84438191
9Primary immunodeficiency_Homo sapiens_hsa053401.70111469
10Leishmaniasis_Homo sapiens_hsa051401.68933061
11Osteoclast differentiation_Homo sapiens_hsa043801.60276270
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54718553
13T cell receptor signaling pathway_Homo sapiens_hsa046601.47726671
14Nicotine addiction_Homo sapiens_hsa050331.45531577
15Olfactory transduction_Homo sapiens_hsa047401.44749317
16Synaptic vesicle cycle_Homo sapiens_hsa047211.42374253
17Chemokine signaling pathway_Homo sapiens_hsa040621.41039239
18Morphine addiction_Homo sapiens_hsa050321.40417683
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40132147
20Antigen processing and presentation_Homo sapiens_hsa046121.33284516
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.28405297
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26631186
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26033898
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25646620
25Shigellosis_Homo sapiens_hsa051311.25571057
26Glutamatergic synapse_Homo sapiens_hsa047241.24608818
27Dopaminergic synapse_Homo sapiens_hsa047281.23909019
28Circadian entrainment_Homo sapiens_hsa047131.23678050
29VEGF signaling pathway_Homo sapiens_hsa043701.19282818
30Tuberculosis_Homo sapiens_hsa051521.18127683
31Malaria_Homo sapiens_hsa051441.16957824
32Long-term depression_Homo sapiens_hsa047301.16103094
33Amphetamine addiction_Homo sapiens_hsa050311.15044562
34GABAergic synapse_Homo sapiens_hsa047271.10269279
35Salmonella infection_Homo sapiens_hsa051321.07959542
36Salivary secretion_Homo sapiens_hsa049701.06626576
37Graft-versus-host disease_Homo sapiens_hsa053321.06239176
38Oxytocin signaling pathway_Homo sapiens_hsa049211.04791595
39Cholinergic synapse_Homo sapiens_hsa047251.04172912
40Platelet activation_Homo sapiens_hsa046111.03395944
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02178120
42Gastric acid secretion_Homo sapiens_hsa049710.99440779
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99271950
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98902779
45Pertussis_Homo sapiens_hsa051330.98804301
46Colorectal cancer_Homo sapiens_hsa052100.98126648
47Glioma_Homo sapiens_hsa052140.98120899
48Type I diabetes mellitus_Homo sapiens_hsa049400.97898707
49Renin secretion_Homo sapiens_hsa049240.97606313
50TNF signaling pathway_Homo sapiens_hsa046680.96656293
51Proteasome_Homo sapiens_hsa030500.95618197
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95502608
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.93726875
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93392218
55Non-small cell lung cancer_Homo sapiens_hsa052230.93150522
56Measles_Homo sapiens_hsa051620.92185285
57GnRH signaling pathway_Homo sapiens_hsa049120.90819486
58Viral myocarditis_Homo sapiens_hsa054160.90715600
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89730279
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89571602
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.89297400
62Estrogen signaling pathway_Homo sapiens_hsa049150.89225961
63DNA replication_Homo sapiens_hsa030300.87923932
64Oocyte meiosis_Homo sapiens_hsa041140.87703067
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87414528
66Allograft rejection_Homo sapiens_hsa053300.86018270
67Hematopoietic cell lineage_Homo sapiens_hsa046400.85957575
68Endocytosis_Homo sapiens_hsa041440.85850306
69Pancreatic cancer_Homo sapiens_hsa052120.85460629
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84659907
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84435549
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.84294382
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80613256
74Toxoplasmosis_Homo sapiens_hsa051450.79602684
75Gap junction_Homo sapiens_hsa045400.79046660
76Hepatitis B_Homo sapiens_hsa051610.78663536
77MAPK signaling pathway_Homo sapiens_hsa040100.78444248
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78010972
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.77241620
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77054489
81Serotonergic synapse_Homo sapiens_hsa047260.76985352
82Chronic myeloid leukemia_Homo sapiens_hsa052200.76461978
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76455244
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76211437
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76206227
86Renal cell carcinoma_Homo sapiens_hsa052110.75666298
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75223130
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.75086027
89Acute myeloid leukemia_Homo sapiens_hsa052210.72646274
90Other glycan degradation_Homo sapiens_hsa005110.72244192
91mTOR signaling pathway_Homo sapiens_hsa041500.71367645
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70165592
93Asthma_Homo sapiens_hsa053100.69689633
94Hepatitis C_Homo sapiens_hsa051600.69357723
95cAMP signaling pathway_Homo sapiens_hsa040240.68233534
96Calcium signaling pathway_Homo sapiens_hsa040200.67611985
97Systemic lupus erythematosus_Homo sapiens_hsa053220.67492074
98Phagosome_Homo sapiens_hsa041450.67080301
99Cocaine addiction_Homo sapiens_hsa050300.65842071
100ErbB signaling pathway_Homo sapiens_hsa040120.65288996
101Influenza A_Homo sapiens_hsa051640.64524578
102Collecting duct acid secretion_Homo sapiens_hsa049660.63960467
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63871262
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63774857
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61420873
106Herpes simplex infection_Homo sapiens_hsa051680.61345485
107Choline metabolism in cancer_Homo sapiens_hsa052310.61280840
108Apoptosis_Homo sapiens_hsa042100.61059571
109African trypanosomiasis_Homo sapiens_hsa051430.60839951
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60038747
111Type II diabetes mellitus_Homo sapiens_hsa049300.59987967
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59629539
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.58651893
114Epstein-Barr virus infection_Homo sapiens_hsa051690.57769395
115Lysosome_Homo sapiens_hsa041420.57703305
116Non-homologous end-joining_Homo sapiens_hsa034500.57065612
117Viral carcinogenesis_Homo sapiens_hsa052030.56364240
118Dorso-ventral axis formation_Homo sapiens_hsa043200.56117313
119Regulation of autophagy_Homo sapiens_hsa041400.55717665
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55657395
121HTLV-I infection_Homo sapiens_hsa051660.55406446
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37968130
123Prolactin signaling pathway_Homo sapiens_hsa049170.37473490
124Spliceosome_Homo sapiens_hsa030400.32263670
125HIF-1 signaling pathway_Homo sapiens_hsa040660.27714814
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26156998
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23041901
128FoxO signaling pathway_Homo sapiens_hsa040680.22843887
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.15816206
130RNA degradation_Homo sapiens_hsa030180.15246766
131Mismatch repair_Homo sapiens_hsa034300.13506458
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.11571489
133Homologous recombination_Homo sapiens_hsa034400.09845597
134mRNA surveillance pathway_Homo sapiens_hsa030150.08850842
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07721213
136RNA transport_Homo sapiens_hsa030130.06390368

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