FAM53A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA synthesis involved in DNA repair (GO:0000731)6.78188396
2synapsis (GO:0007129)5.72221858
3response to peptidoglycan (GO:0032494)5.59789290
4DNA deamination (GO:0045006)5.47029601
5chromosome organization involved in meiosis (GO:0070192)4.93679545
6ribosomal small subunit assembly (GO:0000028)4.89030926
7male meiosis I (GO:0007141)4.78664980
8regulation of mitochondrial translation (GO:0070129)4.75547339
9piRNA metabolic process (GO:0034587)4.70625635
10synaptonemal complex assembly (GO:0007130)4.70250859
11response to muramyl dipeptide (GO:0032495)4.47425425
12misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.23717810
13positive regulation of gamma-delta T cell activation (GO:0046645)4.22530969
14synaptonemal complex organization (GO:0070193)4.05031683
15ubiquinone biosynthetic process (GO:0006744)4.03744444
16viral transcription (GO:0019083)4.02934835
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00603724
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00603724
19translational termination (GO:0006415)3.88368651
20DNA strand elongation involved in DNA replication (GO:0006271)3.87542610
21meiotic nuclear division (GO:0007126)3.87477392
22base-excision repair, AP site formation (GO:0006285)3.83424931
23regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.79766754
24meiosis I (GO:0007127)3.78048584
25telomere maintenance via semi-conservative replication (GO:0032201)3.73729620
26pinocytosis (GO:0006907)3.72416749
27DNA methylation involved in gamete generation (GO:0043046)3.72002687
28translational elongation (GO:0006414)3.69862284
29DNA strand elongation (GO:0022616)3.68192245
30protein retention in ER lumen (GO:0006621)3.66122950
31pentose metabolic process (GO:0019321)3.58970463
32maturation of SSU-rRNA (GO:0030490)3.58387880
33regulation of gamma-delta T cell differentiation (GO:0045586)3.57349659
34regulation of T-helper 2 cell differentiation (GO:0045628)3.56757612
35grooming behavior (GO:0007625)3.54306401
36male meiosis (GO:0007140)3.54294840
37DNA replication initiation (GO:0006270)3.53371934
38negative regulation of mRNA processing (GO:0050686)3.50492382
39folic acid-containing compound biosynthetic process (GO:0009396)3.48752615
40DNA unwinding involved in DNA replication (GO:0006268)3.48261018
41guanosine-containing compound biosynthetic process (GO:1901070)3.46250037
42UTP biosynthetic process (GO:0006228)3.42596889
43regulation of histone H3-K9 methylation (GO:0051570)3.41824949
44GTP biosynthetic process (GO:0006183)3.37694463
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36890169
46UV protection (GO:0009650)3.36809398
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36064202
48antigen processing and presentation of endogenous antigen (GO:0019883)3.35961363
49definitive hemopoiesis (GO:0060216)3.33077045
50ubiquinone metabolic process (GO:0006743)3.32436302
51IMP biosynthetic process (GO:0006188)3.32050684
52positive regulation of megakaryocyte differentiation (GO:0045654)3.29915694
53ribosomal small subunit biogenesis (GO:0042274)3.27748245
54regulation of gamma-delta T cell activation (GO:0046643)3.27748118
55response to misfolded protein (GO:0051788)3.27444236
56nucleobase biosynthetic process (GO:0046112)3.26534743
57regulation of interleukin-6 biosynthetic process (GO:0045408)3.25714508
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23935661
59protein targeting to ER (GO:0045047)3.22202476
60telomere maintenance via recombination (GO:0000722)3.22035442
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21707399
62cotranslational protein targeting to membrane (GO:0006613)3.19288417
63centrosome duplication (GO:0051298)3.18731948
64IMP metabolic process (GO:0046040)3.18414900
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16276265
66translational initiation (GO:0006413)3.15970997
67negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.15443814
68formation of translation preinitiation complex (GO:0001731)3.15224574
69cellular hyperosmotic response (GO:0071474)3.14588909
70purine nucleobase biosynthetic process (GO:0009113)3.13011215
71quinone biosynthetic process (GO:1901663)3.12515847
72opioid receptor signaling pathway (GO:0038003)3.11544147
73DNA biosynthetic process (GO:0071897)3.08558212
74establishment of integrated proviral latency (GO:0075713)3.06746222
75purine deoxyribonucleotide catabolic process (GO:0009155)3.06701981
76antigen processing and presentation via MHC class Ib (GO:0002475)3.06387192
77negative regulation of cell killing (GO:0031342)3.05475215
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05475215
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05428737
80UTP metabolic process (GO:0046051)3.05144119
81negative regulation of mRNA metabolic process (GO:1903312)3.02655358
82protein localization to endoplasmic reticulum (GO:0070972)3.02288909
83viral life cycle (GO:0019058)3.02214339
84regulation of T-helper 1 cell differentiation (GO:0045625)3.00921835
85response to protozoan (GO:0001562)3.00068643
86estrogen biosynthetic process (GO:0006703)3.00039785
87proline biosynthetic process (GO:0006561)2.98993727
88pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96553347
89pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94207075
90DNA packaging (GO:0006323)2.91912973
91deoxyribonucleotide catabolic process (GO:0009264)2.91828140
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89050007
93ribosomal large subunit biogenesis (GO:0042273)2.88497647
94pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88114158
95ribonucleoprotein complex biogenesis (GO:0022613)2.87476851
96mature B cell differentiation involved in immune response (GO:0002313)2.86688344
97telomere maintenance via telomere lengthening (GO:0010833)2.86205502
98positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.86029324
99mitotic recombination (GO:0006312)2.85417935
100nucleobase-containing small molecule interconversion (GO:0015949)2.84588294
101hyaluronan catabolic process (GO:0030214)2.83771392
102ribosome biogenesis (GO:0042254)2.82674385
103chaperone mediated protein folding requiring cofactor (GO:0051085)2.82589316
104CTP biosynthetic process (GO:0006241)2.81448755
105CTP metabolic process (GO:0046036)2.81448755
106regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80018072
107positive thymic T cell selection (GO:0045059)2.79560515
108establishment of viral latency (GO:0019043)2.79284284
109cellular protein complex disassembly (GO:0043624)2.78731325
110deoxyribose phosphate catabolic process (GO:0046386)2.78652780
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77887814
112meiotic cell cycle process (GO:1903046)2.77029626
113meiotic chromosome segregation (GO:0045132)2.76292205
114histone H3-K36 demethylation (GO:0070544)2.75251628
115pseudouridine synthesis (GO:0001522)2.74693529
116deoxyribose phosphate biosynthetic process (GO:0046385)2.73410991
1172-deoxyribonucleotide biosynthetic process (GO:0009265)2.73410991
118viral mRNA export from host cell nucleus (GO:0046784)2.72911175
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72652670
120negative regulation of erythrocyte differentiation (GO:0045647)2.72361864
121regulation of hypersensitivity (GO:0002883)2.71596257
122binding of sperm to zona pellucida (GO:0007339)2.67286297
123pteridine-containing compound biosynthetic process (GO:0042559)2.63941242
124T cell apoptotic process (GO:0070231)2.63491600
125pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63384892
126autophagic vacuole fusion (GO:0000046)2.63152888
127folic acid metabolic process (GO:0046655)2.61102829
128nuclear-transcribed mRNA catabolic process (GO:0000956)2.60834689
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.60247425
130short-chain fatty acid metabolic process (GO:0046459)2.59026722
131DNA replication checkpoint (GO:0000076)2.57505331
132defense response to protozoan (GO:0042832)2.56879425
133hematopoietic stem cell differentiation (GO:0060218)2.56758901
134protein complex disassembly (GO:0043241)2.56218966
135pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.54573515
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54395274
137negative regulation of JAK-STAT cascade (GO:0046426)2.53362069
138mRNA catabolic process (GO:0006402)2.52081191
139valine metabolic process (GO:0006573)2.51036100
140RNA catabolic process (GO:0006401)2.50520403
141nuclear envelope reassembly (GO:0031468)2.50302800
142mitotic nuclear envelope reassembly (GO:0007084)2.50302800
143regulation of necroptotic process (GO:0060544)2.49892156
144pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.48537293
145mitochondrial RNA metabolic process (GO:0000959)2.46473175
146telomere organization (GO:0032200)2.45447091
147translesion synthesis (GO:0019985)2.44388020
148telomere maintenance (GO:0000723)2.44130940
149mitotic nuclear envelope disassembly (GO:0007077)2.41688180
150translation (GO:0006412)2.40241726
151negative regulation of RNA splicing (GO:0033119)2.38390967
152macromolecular complex disassembly (GO:0032984)2.38289935
153negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37416851
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36424169
1553-UTR-mediated mRNA stabilization (GO:0070935)2.35098620
156purine-containing compound salvage (GO:0043101)2.34793304
157rRNA processing (GO:0006364)2.32890412
158proteasome assembly (GO:0043248)2.29625334
159negative T cell selection (GO:0043383)2.29061310
160DNA duplex unwinding (GO:0032508)2.26894705
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26266427
162rRNA modification (GO:0000154)2.26247782
163glycine metabolic process (GO:0006544)2.26211951
164nucleoside salvage (GO:0043174)2.26073830
165regulation of T cell mediated cytotoxicity (GO:0001914)2.25452947
166negative thymic T cell selection (GO:0045060)2.24932195
167DNA geometric change (GO:0032392)2.24674549
168rRNA metabolic process (GO:0016072)2.24571241
169tetrahydrofolate metabolic process (GO:0046653)2.23822277
170base-excision repair (GO:0006284)2.22037828
171somatic hypermutation of immunoglobulin genes (GO:0016446)2.21520241
172somatic diversification of immune receptors via somatic mutation (GO:0002566)2.21520241
173somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.21080629
174isotype switching (GO:0045190)2.21080629
175somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.21080629
176pentose-phosphate shunt (GO:0006098)2.20526263
177pyrimidine nucleotide catabolic process (GO:0006244)2.19783597
178NIK/NF-kappaB signaling (GO:0038061)2.19373037
179chromatin remodeling at centromere (GO:0031055)2.18588714
180positive regulation of isotype switching (GO:0045830)2.18462843
181positive regulation of T cell mediated cytotoxicity (GO:0001916)2.18221705
182negative regulation of necroptotic process (GO:0060546)2.17328463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01407066
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72571492
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.37279100
4MYC_22102868_ChIP-Seq_BL_Human2.49360542
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35728441
6* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27243542
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21790381
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16120271
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13008457
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12854568
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11870353
12LXR_22292898_ChIP-Seq_THP-1_Human2.11066450
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.10437340
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09731598
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08791459
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.04419810
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02868045
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95600004
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.94302651
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.92839872
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.91685866
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89485195
23XRN2_22483619_ChIP-Seq_HELA_Human1.89206653
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.88985273
25VDR_21846776_ChIP-Seq_THP-1_Human1.88225283
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82162516
27VDR_23849224_ChIP-Seq_CD4+_Human1.77713708
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.77341908
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74902774
30CIITA_25753668_ChIP-Seq_RAJI_Human1.74619810
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74175171
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69445229
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69381080
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69347724
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69194868
36* P68_20966046_ChIP-Seq_HELA_Human1.68862883
37ZNF263_19887448_ChIP-Seq_K562_Human1.67614461
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.67177494
39* BCL6_27268052_Chip-Seq_Bcells_Human1.66611947
40FOXP3_21729870_ChIP-Seq_TREG_Human1.63746801
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62701159
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62603940
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61161475
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.60593819
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59592950
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58206678
47GABP_19822575_ChIP-Seq_HepG2_Human1.57331780
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55691158
49DCP1A_22483619_ChIP-Seq_HELA_Human1.55023289
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54920973
51SCL_19346495_ChIP-Seq_HPC-7_Human1.54544047
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.53880908
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52267803
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52221392
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.51011130
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50238993
57* BCOR_27268052_Chip-Seq_Bcells_Human1.50014295
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49258246
59MAF_26560356_Chip-Seq_TH1_Human1.48492216
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42949186
61RACK7_27058665_Chip-Seq_MCF-7_Human1.42151547
62* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.40728743
63SPI1_23547873_ChIP-Seq_NB4_Human1.40410060
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.38779215
65CTCF_21964334_Chip-Seq_Bcells_Human1.38548198
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37512386
67* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37213222
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35771579
69UTX_26944678_Chip-Seq_JUKART_Human1.34884540
70* PHF8_20622854_ChIP-Seq_HELA_Human1.32585191
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31927826
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31608598
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31254785
74NCOR1_26117541_ChIP-Seq_K562_Human1.30802397
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29544310
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29203742
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.28976207
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28879288
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27562876
80SMC4_20622854_ChIP-Seq_HELA_Human1.27497000
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.26385731
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24388849
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23966694
84TTF2_22483619_ChIP-Seq_HELA_Human1.23081380
85AR_21909140_ChIP-Seq_LNCAP_Human1.22841941
86MYB_26560356_Chip-Seq_TH1_Human1.22219182
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21804944
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21185476
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21141674
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.20880834
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20876365
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.20780781
93KDM2B_26808549_Chip-Seq_DND41_Human1.20650856
94MYB_26560356_Chip-Seq_TH2_Human1.20614973
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20564320
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19742312
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.19452110
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18384560
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17719087
100PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17507810
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17168180
102* RUNX1_22412390_ChIP-Seq_EML_Mouse1.16382460
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15889731
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15675439
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14753256
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14580891
107TCF7_22412390_ChIP-Seq_EML_Mouse1.14394887
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14349376
109* MAF_26560356_Chip-Seq_TH2_Human1.13933001
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13720475
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13602748
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12402507
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12268073
114* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12005239
115* E2F1_20622854_ChIP-Seq_HELA_Human1.11989958
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11973657
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11827680
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11744509
119KDM5A_27292631_Chip-Seq_BREAST_Human1.11662447
120* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11600329
121* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11597456
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11309753
123TFEB_21752829_ChIP-Seq_HELA_Human1.10339557
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10121824
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09977257
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09839940
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08673856
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06877947
129ATF3_27146783_Chip-Seq_COLON_Human1.06387430
130GATA1_22025678_ChIP-Seq_K562_Human1.06265968
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05647011
132* ETS1_21867929_ChIP-Seq_TH2_Mouse1.05639127
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.05129967
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.04908437
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04585796
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04448884
137VDR_24763502_ChIP-Seq_THP-1_Human1.04132011
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02507370
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02469632
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01887192
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99964447
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93858092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.43887058
2MP0002396_abnormal_hematopoietic_system2.92968874
3MP0005451_abnormal_body_composition2.83102920
4MP0003763_abnormal_thymus_physiology2.81191002
5MP0000678_abnormal_parathyroid_gland2.78790803
6MP0008260_abnormal_autophagy2.70135245
7MP0004510_myositis2.47320179
8MP0010094_abnormal_chromosome_stability2.42675898
9MP0004957_abnormal_blastocyst_morpholog2.38540907
10MP0003806_abnormal_nucleotide_metabolis2.31657439
11MP0003111_abnormal_nucleus_morphology2.28651589
12MP0000685_abnormal_immune_system2.28382966
13MP0005058_abnormal_lysosome_morphology2.28272433
14MP0003077_abnormal_cell_cycle2.23440559
15MP0005076_abnormal_cell_differentiation2.21448528
16MP0002234_abnormal_pharynx_morphology2.20213710
17MP0004185_abnormal_adipocyte_glucose2.17642452
18MP0003303_peritoneal_inflammation2.16798288
19MP0001835_abnormal_antigen_presentation2.09953439
20MP0005410_abnormal_fertilization2.03055020
21MP0004233_abnormal_muscle_weight1.86823245
22MP0008058_abnormal_DNA_repair1.85140107
23MP0003646_muscle_fatigue1.82516436
24MP0005671_abnormal_response_to1.82034143
25MP0000015_abnormal_ear_pigmentation1.81575209
26MP0001545_abnormal_hematopoietic_system1.78984875
27MP0005397_hematopoietic_system_phenotyp1.78984875
28MP0004808_abnormal_hematopoietic_stem1.77898001
29MP0010352_gastrointestinal_tract_polyps1.75337953
30MP0001853_heart_inflammation1.72720751
31MP0002398_abnormal_bone_marrow1.71578255
32MP0000490_abnormal_crypts_of1.69611520
33MP0009333_abnormal_splenocyte_physiolog1.69471304
34MP0005220_abnormal_exocrine_pancreas1.66387725
35MP0009785_altered_susceptibility_to1.66371525
36MP0001800_abnormal_humoral_immune1.64964126
37MP0008007_abnormal_cellular_replicative1.64876685
38MP0008057_abnormal_DNA_replication1.60045181
39MP0000689_abnormal_spleen_morphology1.58337104
40MP0002722_abnormal_immune_system1.56818513
41MP0002166_altered_tumor_susceptibility1.54515531
42MP0001929_abnormal_gametogenesis1.50852128
43MP0001873_stomach_inflammation1.47497160
44MP0002019_abnormal_tumor_incidence1.46829718
45MP0002452_abnormal_antigen_presenting1.46777436
46MP0005666_abnormal_adipose_tissue1.45973715
47MP0002723_abnormal_immune_serum1.45510186
48MP0000703_abnormal_thymus_morphology1.44684584
49MP0005025_abnormal_response_to1.43646835
50MP0002420_abnormal_adaptive_immunity1.43373349
51MP0000681_abnormal_thyroid_gland1.43358782
52MP0000716_abnormal_immune_system1.42592851
53MP0001819_abnormal_immune_cell1.41742131
54MP0002210_abnormal_sex_determination1.41190850
55MP0001881_abnormal_mammary_gland1.40499948
56MP0006036_abnormal_mitochondrial_physio1.39711222
57MP0002429_abnormal_blood_cell1.38471707
58MP0003191_abnormal_cellular_cholesterol1.38408601
59MP0002160_abnormal_reproductive_system1.35479601
60MP0003436_decreased_susceptibility_to1.34705662
61MP0009840_abnormal_foam_cell1.34434454
62MP0003453_abnormal_keratinocyte_physiol1.33841127
63MP0002405_respiratory_system_inflammati1.32151797
64MP0002132_abnormal_respiratory_system1.30302065
65MP0000858_altered_metastatic_potential1.28715722
66MP0005375_adipose_tissue_phenotype1.27557674
67MP0003186_abnormal_redox_activity1.27380131
68MP0005000_abnormal_immune_tolerance1.25245067
69MP0003698_abnormal_male_reproductive1.24912195
70MP0010155_abnormal_intestine_physiology1.24050110
71MP0005464_abnormal_platelet_physiology1.23953328
72MP0005360_urolithiasis1.21421343
73MP0000749_muscle_degeneration1.20013417
74MP0002060_abnormal_skin_morphology1.19821202
75MP0006082_CNS_inflammation1.18917051
76MP0001790_abnormal_immune_system1.17583381
77MP0005387_immune_system_phenotype1.17583381
78MP0002006_tumorigenesis1.15661875
79MP0009278_abnormal_bone_marrow1.14955683
80MP0005365_abnormal_bile_salt1.14523179
81MP0006054_spinal_hemorrhage1.12855996
82MP0005621_abnormal_cell_physiology1.12671045
83MP0001145_abnormal_male_reproductive1.12106991
84MP0000313_abnormal_cell_death1.09901812
85MP0009384_cardiac_valve_regurgitation1.07951510
86MP0002419_abnormal_innate_immunity1.07576993
87MP0000653_abnormal_sex_gland1.04977514
88MP0003718_maternal_effect1.04494461
89MP0001533_abnormal_skeleton_physiology1.02941471
90MP0003567_abnormal_fetal_cardiomyocyte1.02779234
91MP0001845_abnormal_inflammatory_respons1.02687501
92MP0001730_embryonic_growth_arrest1.02308834
93MP0001661_extended_life_span1.01707971
94MP0008469_abnormal_protein_level1.01089711
95MP0010307_abnormal_tumor_latency1.00953549
96MP0003866_abnormal_defecation1.00050126
97MP0008877_abnormal_DNA_methylation0.99201653
98MP0005501_abnormal_skin_physiology0.98789354
99MP0005670_abnormal_white_adipose0.97365976
100MP0000350_abnormal_cell_proliferation0.96968689
101MP0005330_cardiomyopathy0.96511269
102MP0002269_muscular_atrophy0.95463546
103MP0008438_abnormal_cutaneous_collagen0.95128016
104MP0003448_altered_tumor_morphology0.94907500
105MP0003786_premature_aging0.94393890
106MP0000609_abnormal_liver_physiology0.93961689
107MP0003221_abnormal_cardiomyocyte_apopto0.93861516
108MP0003172_abnormal_lysosome_physiology0.91921481
109MP0004947_skin_inflammation0.91619420
110MP0005390_skeleton_phenotype0.90921586
111MP0004147_increased_porphyrin_level0.90875060
112MP0000750_abnormal_muscle_regeneration0.90795938
113MP0003705_abnormal_hypodermis_morpholog0.89983292
114MP0005319_abnormal_enzyme/_coenzyme0.89776455
115MP0002139_abnormal_hepatobiliary_system0.88376372
116MP0010030_abnormal_orbit_morphology0.87564942
117MP0000598_abnormal_liver_morphology0.87455044
118MP0001849_ear_inflammation0.86693301
119MP0005023_abnormal_wound_healing0.86345170
120MP0005075_abnormal_melanosome_morpholog0.84134285
121MP0000358_abnormal_cell_content/0.83554565
122MP0002148_abnormal_hypersensitivity_rea0.83139235
123MP0001958_emphysema0.82665660
124MP0005384_cellular_phenotype0.82532875
125MP0000627_abnormal_mammary_gland0.82041008
126MP0008932_abnormal_embryonic_tissue0.81129579
127MP0002080_prenatal_lethality0.79922809
128MP0002161_abnormal_fertility/fecundity0.79040810
129MP0003943_abnormal_hepatobiliary_system0.78392354
130MP0003699_abnormal_female_reproductive0.78187546
131MP0000465_gastrointestinal_hemorrhage0.77947540
132MP0002970_abnormal_white_adipose0.77205469
133MP0003724_increased_susceptibility_to0.76618445
134MP0000747_muscle_weakness0.76483257
135MP0003566_abnormal_cell_adhesion0.75161631
136MP0005174_abnormal_tail_pigmentation0.75116072
137MP0000759_abnormal_skeletal_muscle0.74761016
138MP0003656_abnormal_erythrocyte_physiolo0.74671350
139MP0005085_abnormal_gallbladder_physiolo0.72247700
140MP0009643_abnormal_urine_homeostasis0.71738438
141MP0002971_abnormal_brown_adipose0.71502680
142MP0006035_abnormal_mitochondrial_morpho0.71471438
143MP0002796_impaired_skin_barrier0.71014273
144MP0001672_abnormal_embryogenesis/_devel0.70801384
145MP0005380_embryogenesis_phenotype0.70801384
146MP0010368_abnormal_lymphatic_system0.70732885
147MP0003984_embryonic_growth_retardation0.70695903
148MP0004087_abnormal_muscle_fiber0.70023456
149MP0002106_abnormal_muscle_physiology0.69923058

Predicted human phenotypes

RankGene SetZ-score
1Cheilitis (HP:0100825)3.86898146
2Recurrent cutaneous fungal infections (HP:0011370)3.74045466
3Chronic mucocutaneous candidiasis (HP:0002728)3.74045466
4Abnormality of cells of the erythroid lineage (HP:0012130)3.73130573
5Abnormal number of erythroid precursors (HP:0012131)3.70199748
6Thrombocytosis (HP:0001894)3.57498777
7Aplastic anemia (HP:0001915)3.47572483
8Hand muscle atrophy (HP:0009130)3.41219200
9Reticulocytopenia (HP:0001896)3.34591274
10T lymphocytopenia (HP:0005403)3.16301045
11Hypertensive crisis (HP:0100735)3.14914739
12Distal upper limb amyotrophy (HP:0007149)3.12560203
13Upper limb amyotrophy (HP:0009129)3.12560203
14Achilles tendon contracture (HP:0001771)3.12142088
15Severe visual impairment (HP:0001141)3.07523259
16Loss of speech (HP:0002371)3.05762519
17Abnormality of T cell number (HP:0011839)3.05005324
18Broad distal phalanx of finger (HP:0009836)3.00529291
19Recurrent skin infections (HP:0001581)2.99301427
20IgM deficiency (HP:0002850)2.95882177
21Abnormality of T cells (HP:0002843)2.93535246
22Colon cancer (HP:0003003)2.83110503
23Elevated erythrocyte sedimentation rate (HP:0003565)2.80345405
24Rhabdomyolysis (HP:0003201)2.72958065
25Recurrent bacterial skin infections (HP:0005406)2.70885053
26Prostate neoplasm (HP:0100787)2.69498458
27Tubulointerstitial nephritis (HP:0001970)2.69082562
28Abnormality of the Achilles tendon (HP:0005109)2.68912199
29Increased intramyocellular lipid droplets (HP:0012240)2.66919051
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65654409
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65654409
32Recurrent bronchitis (HP:0002837)2.61619087
33Oral leukoplakia (HP:0002745)2.60858025
34Abnormality of the nasal mucosa (HP:0000433)2.55765646
35Petechiae (HP:0000967)2.52492777
36Hypertriglyceridemia (HP:0002155)2.52274948
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.50757265
38Nasal polyposis (HP:0100582)2.50102275
39Chronic otitis media (HP:0000389)2.49423910
40Reduced antithrombin III activity (HP:0001976)2.48037114
41Abnormality of T cell physiology (HP:0011840)2.45198076
42Premature skin wrinkling (HP:0100678)2.45181753
43Abnormal mitochondria in muscle tissue (HP:0008316)2.44438386
44Microvesicular hepatic steatosis (HP:0001414)2.44380026
45Exercise-induced myalgia (HP:0003738)2.40814801
46Pallor (HP:0000980)2.40446417
47Cellulitis (HP:0100658)2.33019333
48Generalized aminoaciduria (HP:0002909)2.30177937
49Myositis (HP:0100614)2.30095925
50Hepatocellular necrosis (HP:0001404)2.29992556
51Myoglobinuria (HP:0002913)2.29897590
52Pili torti (HP:0003777)2.29555359
53Recurrent viral infections (HP:0004429)2.29317040
54Abnormality of macrophages (HP:0004311)2.27907829
55Microretrognathia (HP:0000308)2.27672783
56Hypergonadotropic hypogonadism (HP:0000815)2.26692417
57Rectal prolapse (HP:0002035)2.26419961
58Growth hormone excess (HP:0000845)2.25287527
59Multiple enchondromatosis (HP:0005701)2.24991576
60Thoracic kyphosis (HP:0002942)2.24883592
61Hypoplasia of the thymus (HP:0000778)2.23942306
62Obstructive lung disease (HP:0006536)2.22392766
63Chronic obstructive pulmonary disease (HP:0006510)2.22392766
64Dicarboxylic aciduria (HP:0003215)2.20069135
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20069135
66Generalized amyotrophy (HP:0003700)2.19780636
67Poikiloderma (HP:0001029)2.18841193
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18501992
69Upper motor neuron abnormality (HP:0002127)2.16599639
70Lymphoma (HP:0002665)2.16224251
71Abnormality of liposaccharide metabolism (HP:0010968)2.16144563
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.16144563
73Abnormality of glycolipid metabolism (HP:0010969)2.16144563
74Muscle fiber atrophy (HP:0100295)2.14467346
75Seborrheic dermatitis (HP:0001051)2.14167947
76Panhypogammaglobulinemia (HP:0003139)2.14051174
77Bulbar palsy (HP:0001283)2.13822743
78Abnormality of the parathyroid morphology (HP:0011766)2.13340414
79Macrocytic anemia (HP:0001972)2.12604561
80Ulnar deviation of the wrist (HP:0003049)2.12218897
81Pancytopenia (HP:0001876)2.11684063
82Elbow flexion contracture (HP:0002987)2.10427160
83Recurrent abscess formation (HP:0002722)2.10043085
84Spastic paraparesis (HP:0002313)2.10017139
85Protrusio acetabuli (HP:0003179)2.09759196
86Increased serum ferritin (HP:0003281)2.09002178
87Type 2 muscle fiber atrophy (HP:0003554)2.08683521
88Difficulty climbing stairs (HP:0003551)2.08421984
89Abnormality of subcutaneous fat tissue (HP:0001001)2.06842442
90Epistaxis (HP:0000421)2.06067103
91Selective tooth agenesis (HP:0001592)2.05603547
92Short nail (HP:0001799)2.05278851
93Hyperthyroidism (HP:0000836)2.04743326
94Abnormality of the thoracic spine (HP:0100711)2.03601800
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.02388363
96High pitched voice (HP:0001620)2.01136207
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01060916
98Failure to thrive in infancy (HP:0001531)1.99610719
99Long palpebral fissure (HP:0000637)1.98965984
100Type I transferrin isoform profile (HP:0003642)1.98792153
101Atelectasis (HP:0100750)1.98515459
102Combined immunodeficiency (HP:0005387)1.98218409
103Amaurosis fugax (HP:0100576)1.97975161
104Abnormality of fatty-acid metabolism (HP:0004359)1.97721370
105Prolonged bleeding time (HP:0003010)1.97347275
106Autoimmune thrombocytopenia (HP:0001973)1.96777379
107Follicular hyperkeratosis (HP:0007502)1.96377145
108Mesangial abnormality (HP:0001966)1.96257513
109Birth length less than 3rd percentile (HP:0003561)1.95412933
110Basal cell carcinoma (HP:0002671)1.94696785
111Abnormality of pyrimidine metabolism (HP:0004353)1.94196776
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92166410
113Abnormal protein N-linked glycosylation (HP:0012347)1.92166410
114Abnormal protein glycosylation (HP:0012346)1.92166410
115Abnormal glycosylation (HP:0012345)1.92166410
116Impaired platelet aggregation (HP:0003540)1.91845256
117Abnormal platelet function (HP:0011869)1.91845256
118Severe combined immunodeficiency (HP:0004430)1.90457095
119Insulin resistance (HP:0000855)1.90322382
120IgG deficiency (HP:0004315)1.90132515
121Hypoglycemic coma (HP:0001325)1.89800940
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.89678464
123Aortic valve stenosis (HP:0001650)1.88870340
124Progressive muscle weakness (HP:0003323)1.88862307
125B lymphocytopenia (HP:0010976)1.88661399
126Abnormality of B cell number (HP:0010975)1.88661399
127Ragged-red muscle fibers (HP:0003200)1.87655281
128Hepatic necrosis (HP:0002605)1.87517008
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86748962
130Recurrent fungal infections (HP:0002841)1.86732736
131Gastrointestinal inflammation (HP:0004386)1.86558910
132Muscle fiber inclusion bodies (HP:0100299)1.86300830
133Vertebral compression fractures (HP:0002953)1.86227040
134Hyperammonemia (HP:0001987)1.84991261
135Joint stiffness (HP:0001387)1.84582070
136Bowel incontinence (HP:0002607)1.84508421
137Abnormality of reticulocytes (HP:0004312)1.84424502
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.83850905
139Abnormality of iron homeostasis (HP:0011031)1.83558581
140Lymphopenia (HP:0001888)1.82275050
141Abnormal hair laboratory examination (HP:0003328)1.81960973
142Myopathic facies (HP:0002058)1.81769923
143Granulocytopenia (HP:0001913)1.81019983
144Increased muscle lipid content (HP:0009058)1.80604081
145Late onset (HP:0003584)1.79481303
146Eczematoid dermatitis (HP:0000976)1.79321375
147Mediastinal lymphadenopathy (HP:0100721)1.76694951
148Medulloblastoma (HP:0002885)1.76458302
149Easy fatigability (HP:0003388)1.76418936
150Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75335480
151Entropion (HP:0000621)1.74867803
152Interstitial pulmonary disease (HP:0006530)1.74687716
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74451717
154Hyperparathyroidism (HP:0000843)1.73929604
155Abnormality of DNA repair (HP:0003254)1.73627468
156Fasciculations (HP:0002380)1.72603263
157External ophthalmoplegia (HP:0000544)1.72231700
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.72175635
159Degeneration of anterior horn cells (HP:0002398)1.71434276
160Abnormality of the anterior horn cell (HP:0006802)1.71434276
161J-shaped sella turcica (HP:0002680)1.70728705
162Abnormal large intestine physiology (HP:0012700)1.70499462
163Asymmetric septal hypertrophy (HP:0001670)1.70382669
164Inflammation of the large intestine (HP:0002037)1.70310295
165Premature rupture of membranes (HP:0001788)1.69669663
166Hyperacusis (HP:0010780)1.69389522
167Neuronal loss in central nervous system (HP:0002529)1.68269365
168Calcaneovalgus deformity (HP:0001848)1.67640360
169Abnormality of transition element cation homeostasis (HP:0011030)1.66492701
170Agnosia (HP:0010524)1.64098749
171Delayed CNS myelination (HP:0002188)1.63876433
172Hyperbilirubinemia (HP:0002904)1.63636266
173Nausea (HP:0002018)1.63417386
174Microcytic anemia (HP:0001935)1.63349169
175Spontaneous hematomas (HP:0007420)1.62669523
176Albinism (HP:0001022)1.62668610
177Distal arthrogryposis (HP:0005684)1.62664342
178Slender long bone (HP:0003100)1.62661312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.05343849
2PRPF4B2.87334992
3SMG12.61196486
4FLT32.61079701
5NME22.59186088
6BCKDK2.58442914
7PKN22.50695836
8VRK22.48431962
9EEF2K2.17964899
10TRIB32.17520687
11BUB12.17325431
12MAP3K102.15202431
13MET2.14380833
14CDC72.11596502
15ERN11.97981071
16NEK21.95496944
17RPS6KA41.94898389
18TYK21.92300602
19MAP2K31.90200916
20KDR1.86360682
21WEE11.83737459
22ACVR1B1.80237234
23ZAP701.76401737
24ARAF1.74571940
25JAK31.73843653
26EIF2AK11.56209027
27TESK21.55449236
28STK161.54414017
29TTN1.51953369
30DYRK31.49780640
31IRAK31.45857183
32KIT1.44499174
33ABL21.44231024
34TGFBR11.43684466
35NLK1.43530367
36PASK1.42882130
37BTK1.41105796
38MAPKAPK31.36409550
39MAP3K111.36302321
40RPS6KB21.35817984
41TBK11.34047678
42TGFBR21.34027993
43STK101.32968864
44CDK41.28990875
45PIM21.24723339
46LRRK21.23644996
47PNCK1.22769265
48CCNB11.20292267
49TLK11.16766144
50TEC1.16483031
51CDK71.14095867
52OBSCN1.12956877
53ATR1.12540200
54VRK11.03720112
55PAK41.03248618
56FGFR41.02513584
57EIF2AK31.01519232
58TXK1.01045571
59MAPK110.99172694
60MST1R0.98293641
61LATS10.96860041
62PIM10.95212258
63IKBKE0.94801001
64PTK20.94503117
65ITK0.94125765
66IRAK40.90902853
67CDK90.90571301
68CDK120.87527700
69RPS6KL10.87032140
70RPS6KC10.87032140
71PRKCI0.85989160
72AURKB0.85893304
73MAP3K80.85432326
74BRSK20.85394015
75CHEK20.84758168
76CSF1R0.84301097
77SCYL20.83744965
78PIK3CG0.82461681
79MAPK40.80499040
80EPHA20.79845034
81NEK10.79267109
82SRPK10.75028690
83DAPK10.74519634
84STK40.72835214
85RAF10.71929115
86MAP2K60.71356146
87JAK10.71227020
88AURKA0.70819202
89GRK60.70112792
90IKBKB0.67632337
91TAOK20.67032985
92RPS6KA60.66998172
93PLK40.66784387
94MAP3K130.66257318
95MAP3K30.65536098
96PLK10.65334386
97ILK0.65311401
98CSK0.65051490
99MTOR0.63711831
100BRAF0.62968240
101PTK60.61825043
102PDPK10.61707567
103SIK10.61297413
104ICK0.61029025
105CDK190.59915173
106SYK0.59744156
107BMX0.58609381
108PDGFRA0.57804983
109IRAK20.55819968
110BLK0.55398636
111TAF10.54904184
112PTK2B0.50128927
113LCK0.49959166
114CDK80.48039530
115ZAK0.48002489
116NEK90.47889526
117MARK30.47794099
118TTK0.47244872
119JAK20.45176114
120TNK20.44904090
121NTRK10.44799424
122MELK0.44433305
123MAP3K10.43672659
124LYN0.43020511
125MAP2K20.42853998
126TIE10.42325146
127MOS0.40919358
128MAPKAPK50.40631723
129MAP3K70.39167160
130HCK0.39055963
131AKT20.38163618
132TAOK10.37956966
133CDK20.37841043
134CHEK10.37658227
135TESK10.36219142
136CAMK2G0.35693035
137CDK60.34503909
138MAP3K50.34235667
139CLK10.34078994
140RPS6KA50.33039855
141NUAK10.31643328
142TSSK60.31005233
143RPS6KA10.27742598
144PAK20.26833093
145AKT10.26663852
146MAPKAPK20.26656521
147PDK10.26303862

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30508197
2Mismatch repair_Homo sapiens_hsa034303.24847951
3Ribosome_Homo sapiens_hsa030103.15603644
4Base excision repair_Homo sapiens_hsa034102.67069667
5Primary immunodeficiency_Homo sapiens_hsa053402.31672801
6One carbon pool by folate_Homo sapiens_hsa006702.29145972
7Homologous recombination_Homo sapiens_hsa034402.22431154
8Sulfur relay system_Homo sapiens_hsa041222.20479372
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15476411
10Spliceosome_Homo sapiens_hsa030402.08335000
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03118050
12Pyrimidine metabolism_Homo sapiens_hsa002401.94329821
13Nucleotide excision repair_Homo sapiens_hsa034201.93127513
14Proteasome_Homo sapiens_hsa030501.92609141
15Selenocompound metabolism_Homo sapiens_hsa004501.69561365
16RNA transport_Homo sapiens_hsa030131.64075972
17Non-homologous end-joining_Homo sapiens_hsa034501.62590538
18Folate biosynthesis_Homo sapiens_hsa007901.60317236
19RNA polymerase_Homo sapiens_hsa030201.57253144
20Cell cycle_Homo sapiens_hsa041101.53736953
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50745211
22Antigen processing and presentation_Homo sapiens_hsa046121.40999023
23Fanconi anemia pathway_Homo sapiens_hsa034601.37391689
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.36720026
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35817813
26Herpes simplex infection_Homo sapiens_hsa051681.34250332
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33160603
28RNA degradation_Homo sapiens_hsa030181.29904476
29Allograft rejection_Homo sapiens_hsa053301.27981000
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25593097
31Biosynthesis of amino acids_Homo sapiens_hsa012301.23544311
32p53 signaling pathway_Homo sapiens_hsa041151.17947152
33Autoimmune thyroid disease_Homo sapiens_hsa053201.16669307
34Asthma_Homo sapiens_hsa053101.14969627
35Fatty acid degradation_Homo sapiens_hsa000711.14821902
36Pentose phosphate pathway_Homo sapiens_hsa000301.11635033
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09936716
38Carbon metabolism_Homo sapiens_hsa012001.09365372
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09313856
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.08099674
41Pancreatic cancer_Homo sapiens_hsa052121.05636299
42Phenylalanine metabolism_Homo sapiens_hsa003601.03548632
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02863333
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02494516
45Propanoate metabolism_Homo sapiens_hsa006400.99205183
46Measles_Homo sapiens_hsa051620.98960639
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.97830343
48Purine metabolism_Homo sapiens_hsa002300.92799380
49Graft-versus-host disease_Homo sapiens_hsa053320.87341542
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.85427654
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85176434
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83168246
53VEGF signaling pathway_Homo sapiens_hsa043700.82604149
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82479803
55Legionellosis_Homo sapiens_hsa051340.81944417
56Tuberculosis_Homo sapiens_hsa051520.81106549
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79510902
58Basal transcription factors_Homo sapiens_hsa030220.78777720
59Non-small cell lung cancer_Homo sapiens_hsa052230.78233685
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76774917
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.76647276
62Acute myeloid leukemia_Homo sapiens_hsa052210.75598492
63Hematopoietic cell lineage_Homo sapiens_hsa046400.75182319
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.75093471
65Toxoplasmosis_Homo sapiens_hsa051450.75027211
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74460675
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73225552
68Lysosome_Homo sapiens_hsa041420.72724616
69HTLV-I infection_Homo sapiens_hsa051660.72343996
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72319160
71Bladder cancer_Homo sapiens_hsa052190.72014835
72Glutathione metabolism_Homo sapiens_hsa004800.71472578
73Inositol phosphate metabolism_Homo sapiens_hsa005620.70670720
74Leishmaniasis_Homo sapiens_hsa051400.68688694
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68660809
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67203029
77Fatty acid elongation_Homo sapiens_hsa000620.66957875
78Epstein-Barr virus infection_Homo sapiens_hsa051690.66866213
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66765384
80Galactose metabolism_Homo sapiens_hsa000520.66604087
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66336158
82Other glycan degradation_Homo sapiens_hsa005110.65868273
83Thyroid cancer_Homo sapiens_hsa052160.65449619
84Systemic lupus erythematosus_Homo sapiens_hsa053220.65263978
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64789346
86Vitamin digestion and absorption_Homo sapiens_hsa049770.64535601
87B cell receptor signaling pathway_Homo sapiens_hsa046620.64298450
88Apoptosis_Homo sapiens_hsa042100.63492726
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62877862
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60311002
91Lysine degradation_Homo sapiens_hsa003100.59944715
92Caffeine metabolism_Homo sapiens_hsa002320.58484439
93Salmonella infection_Homo sapiens_hsa051320.58242161
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.57919515
95Small cell lung cancer_Homo sapiens_hsa052220.57710626
96Peroxisome_Homo sapiens_hsa041460.57681999
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57595474
98Viral carcinogenesis_Homo sapiens_hsa052030.57247389
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56920348
100beta-Alanine metabolism_Homo sapiens_hsa004100.56666867
101Osteoclast differentiation_Homo sapiens_hsa043800.56595258
102mRNA surveillance pathway_Homo sapiens_hsa030150.55934604
103Influenza A_Homo sapiens_hsa051640.54659908
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53513719
105Shigellosis_Homo sapiens_hsa051310.52744428
106Pyruvate metabolism_Homo sapiens_hsa006200.52043368
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.51688481
108T cell receptor signaling pathway_Homo sapiens_hsa046600.51071350
109N-Glycan biosynthesis_Homo sapiens_hsa005100.50790619
110Hepatitis B_Homo sapiens_hsa051610.50541516
111Arginine and proline metabolism_Homo sapiens_hsa003300.48901768
112Tryptophan metabolism_Homo sapiens_hsa003800.48891823
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.46311780
114Fructose and mannose metabolism_Homo sapiens_hsa000510.44600313
115Tyrosine metabolism_Homo sapiens_hsa003500.44351526
116Protein export_Homo sapiens_hsa030600.44182433
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43804633
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43688272
119Chronic myeloid leukemia_Homo sapiens_hsa052200.43576953
120Starch and sucrose metabolism_Homo sapiens_hsa005000.43541163
121Notch signaling pathway_Homo sapiens_hsa043300.43326704
122Viral myocarditis_Homo sapiens_hsa054160.43321132
123Type I diabetes mellitus_Homo sapiens_hsa049400.42912804
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41805346
125Pertussis_Homo sapiens_hsa051330.41712103
126ABC transporters_Homo sapiens_hsa020100.40009457
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39595349
128Platelet activation_Homo sapiens_hsa046110.37809698
129Metabolic pathways_Homo sapiens_hsa011000.37372049
130Phagosome_Homo sapiens_hsa041450.37135352
131Fatty acid metabolism_Homo sapiens_hsa012120.36989324
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36789553
133mTOR signaling pathway_Homo sapiens_hsa041500.36706967
134Amoebiasis_Homo sapiens_hsa051460.33322819
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.32404533
136Insulin resistance_Homo sapiens_hsa049310.32332625
137Fatty acid biosynthesis_Homo sapiens_hsa000610.31860901

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