FAM53C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the FAM53 protein family. FAM53 protein family members bind to a transcriptional regulator that modulates cell proliferation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.69108108
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.69108108
3modulation by symbiont of host immune response (GO:0052553)4.69108108
4positive regulation by symbiont of host defense response (GO:0052509)4.69108108
5modulation by symbiont of host defense response (GO:0052031)4.69108108
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.69108108
73-UTR-mediated mRNA stabilization (GO:0070935)4.63448618
8response to peptidoglycan (GO:0032494)4.35511933
9negative regulation of erythrocyte differentiation (GO:0045647)4.26719848
10cellular extravasation (GO:0045123)3.98601461
11response to muramyl dipeptide (GO:0032495)3.82422925
12histone H3-K36 demethylation (GO:0070544)3.77899979
13monoubiquitinated protein deubiquitination (GO:0035520)3.70430702
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69319730
15positive regulation of gamma-delta T cell activation (GO:0046645)3.61885256
16positive regulation of protein homooligomerization (GO:0032464)3.56286917
17piRNA metabolic process (GO:0034587)3.55998564
18macrophage activation involved in immune response (GO:0002281)3.46959627
19negative regulation of cell killing (GO:0031342)3.45896464
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45896464
21microtubule severing (GO:0051013)3.45615713
22dosage compensation (GO:0007549)3.40807099
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28828791
24pre-miRNA processing (GO:0031054)3.25270505
25negative regulation of toll-like receptor signaling pathway (GO:0034122)3.21734814
26detection of other organism (GO:0098543)3.16976370
27detection of molecule of bacterial origin (GO:0032490)3.14302793
28mitotic sister chromatid cohesion (GO:0007064)3.12485343
29male meiosis (GO:0007140)3.11323414
30RNA stabilization (GO:0043489)3.09314359
31mRNA stabilization (GO:0048255)3.09314359
32regulation of interferon-beta biosynthetic process (GO:0045357)3.07762587
33histone H3-K9 demethylation (GO:0033169)3.04239453
34respiratory burst (GO:0045730)3.03041545
35regulation of gamma-delta T cell activation (GO:0046643)3.02950020
36neutrophil mediated immunity (GO:0002446)3.00276486
37intracellular estrogen receptor signaling pathway (GO:0030520)2.97330821
38negative regulation of interleukin-12 production (GO:0032695)2.97122983
39regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.95995008
40regulation of meiosis I (GO:0060631)2.94897065
41layer formation in cerebral cortex (GO:0021819)2.94409462
42regulation of mast cell degranulation (GO:0043304)2.94173324
43neutrophil activation involved in immune response (GO:0002283)2.93852184
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.93666867
45response to host immune response (GO:0052572)2.93666867
46negative regulation of gene expression, epigenetic (GO:0045814)2.93183343
47regulation of leukocyte degranulation (GO:0043300)2.93118708
48histone H3-K9 modification (GO:0061647)2.92812247
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.90288654
50negative regulation of cAMP-mediated signaling (GO:0043951)2.88198688
51erythrocyte development (GO:0048821)2.87637398
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87104540
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85968124
54detection of bacterium (GO:0016045)2.84406653
55regulation of clathrin-mediated endocytosis (GO:2000369)2.83088794
56regulation of chromatin binding (GO:0035561)2.82566309
57regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82420883
58chromatin silencing (GO:0006342)2.82079905
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81624103
60nuclear pore complex assembly (GO:0051292)2.81595028
61histone H3-K4 trimethylation (GO:0080182)2.80702564
62cytoplasmic mRNA processing body assembly (GO:0033962)2.80408665
63negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.79857416
64positive regulation of neurological system process (GO:0031646)2.77904295
65response to host (GO:0075136)2.76539679
66response to host defenses (GO:0052200)2.76539679
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76539679
68regulation of meiosis (GO:0040020)2.76288691
69detection of external biotic stimulus (GO:0098581)2.73895581
70germinal center formation (GO:0002467)2.72769311
71positive regulation by host of viral transcription (GO:0043923)2.71252837
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70075202
73histone H4 deacetylation (GO:0070933)2.69567549
74negative regulation of myotube differentiation (GO:0010832)2.67534070
75synaptonemal complex assembly (GO:0007130)2.67107006
76regulation of RNA export from nucleus (GO:0046831)2.64916637
77embryonic body morphogenesis (GO:0010172)2.62888055
78macrophage activation (GO:0042116)2.62245837
79leukocyte migration involved in inflammatory response (GO:0002523)2.62127926
80regulation of T-helper 2 cell differentiation (GO:0045628)2.61756701
81modulation by virus of host process (GO:0019054)2.61706569
82histone H3-K9 methylation (GO:0051567)2.61254228
83detection of biotic stimulus (GO:0009595)2.61110082
84leukocyte aggregation (GO:0070486)2.61095322
85synaptic vesicle maturation (GO:0016188)2.61039133
86body morphogenesis (GO:0010171)2.60512500
87gene silencing by RNA (GO:0031047)2.60489203
88granulocyte activation (GO:0036230)2.60355747
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60304417
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.59244051
91regulation of gamma-delta T cell differentiation (GO:0045586)2.59000967
92histone H2A monoubiquitination (GO:0035518)2.58303760
93positive thymic T cell selection (GO:0045059)2.58012668
94olfactory bulb development (GO:0021772)2.57908242
95regulation of mast cell activation involved in immune response (GO:0033006)2.57528884
96regulation of oxidative stress-induced neuron death (GO:1903203)2.57112346
97regulation of hippo signaling (GO:0035330)2.56296936
98neutrophil activation (GO:0042119)2.56198228
99histone H4-K16 acetylation (GO:0043984)2.55923729
100snRNA transcription (GO:0009301)2.53572513
101regulation of B cell receptor signaling pathway (GO:0050855)2.52603371
102regulation of regulated secretory pathway (GO:1903305)2.52559175
103negative regulation of interleukin-6 production (GO:0032715)2.52527814
104mitotic chromosome condensation (GO:0007076)2.52430914
105ovulation cycle (GO:0042698)2.52203012
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.51339329
107sensory perception of smell (GO:0007608)2.51099370
108synaptonemal complex organization (GO:0070193)2.50667935
109regulation of ARF protein signal transduction (GO:0032012)2.50036964
110mRNA transcription from RNA polymerase II promoter (GO:0042789)2.49970959
111negative regulation of histone modification (GO:0031057)2.49519669
112myeloid leukocyte mediated immunity (GO:0002444)2.49258532
113cell migration in hindbrain (GO:0021535)2.49170980
114locomotory exploration behavior (GO:0035641)2.48921753
115regulation of toll-like receptor signaling pathway (GO:0034121)2.47866145
116positive regulation of meiosis (GO:0045836)2.45514787
117peptidyl-threonine dephosphorylation (GO:0035970)2.45075413
118natural killer cell differentiation (GO:0001779)2.44243441
119corticosteroid receptor signaling pathway (GO:0031958)2.43425837
120B cell receptor signaling pathway (GO:0050853)2.43131740
121microglial cell activation (GO:0001774)2.42694693
122positive regulation of protein oligomerization (GO:0032461)2.41610386
123apoptotic process involved in morphogenesis (GO:0060561)2.41310264
124female gamete generation (GO:0007292)2.40876776
125myeloid cell activation involved in immune response (GO:0002275)2.39304719
126protein polyglutamylation (GO:0018095)2.38788688
127synaptic vesicle endocytosis (GO:0048488)2.38608037
128response to pheromone (GO:0019236)2.38522715
129histone H3 deacetylation (GO:0070932)2.38496029
130negative regulation of circadian rhythm (GO:0042754)2.38469853
131nuclear pore organization (GO:0006999)2.37883110
132chromosome condensation (GO:0030261)2.37835481
133modulation by symbiont of host cellular process (GO:0044068)2.37110006
134peptidyl-lysine dimethylation (GO:0018027)2.35925833
135regulation of nucleobase-containing compound transport (GO:0032239)2.33296893
136vesicle transport along microtubule (GO:0047496)2.33181419
137glucocorticoid receptor signaling pathway (GO:0042921)2.32347276
138peptidyl-threonine phosphorylation (GO:0018107)2.31924361
139gene silencing (GO:0016458)2.31612838
140regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30425190
141paraxial mesoderm development (GO:0048339)2.30087220
142regulation of NFAT protein import into nucleus (GO:0051532)2.27689292
143protein localization to endosome (GO:0036010)2.26761387
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26480730
145maintenance of protein location in nucleus (GO:0051457)2.23342016
146regulation of early endosome to late endosome transport (GO:2000641)2.23340332
147positive regulation of gene expression, epigenetic (GO:0045815)2.22564443
148microtubule nucleation (GO:0007020)2.22525155
149peptidyl-threonine modification (GO:0018210)2.21621761
150positive regulation of meiotic cell cycle (GO:0051446)2.19096782
151negative regulation of histone methylation (GO:0031061)2.17500938
152negative regulation of meiosis (GO:0045835)2.16743759
153histone lysine demethylation (GO:0070076)2.16688902
154glutamate secretion (GO:0014047)2.16117083
155DNA methylation (GO:0006306)2.14211554
156DNA alkylation (GO:0006305)2.14211554
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.12945623
158establishment of nucleus localization (GO:0040023)2.12902199
159histone H3-K4 methylation (GO:0051568)2.12252701
160regulation of transforming growth factor beta2 production (GO:0032909)2.11666463
161peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.11492534
162NLS-bearing protein import into nucleus (GO:0006607)2.10683319
163protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.10231354
164regulation of synaptic vesicle exocytosis (GO:2000300)2.09553508
165insulin-like growth factor receptor signaling pathway (GO:0048009)2.08613251
166regulation of meiotic cell cycle (GO:0051445)2.08578426
167histone demethylation (GO:0016577)2.07798239
168negative regulation of hormone biosynthetic process (GO:0032353)2.07495575
169negative regulation of hormone metabolic process (GO:0032351)2.07495575
170notochord development (GO:0030903)2.06515623
171negative regulation of catenin import into nucleus (GO:0035414)2.05753601
172regulation of female gonad development (GO:2000194)2.05452279
173negative regulation of inclusion body assembly (GO:0090084)2.04476281
174histone H2A ubiquitination (GO:0033522)2.04397474
175face morphogenesis (GO:0060325)2.04239030
176regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.03382883
177sodium ion export (GO:0071436)2.03090842
178histone H4-K12 acetylation (GO:0043983)2.02180996
179DNA methylation involved in gamete generation (GO:0043046)2.01871277
180regulation of sister chromatid cohesion (GO:0007063)2.01217209
181cytoskeleton-dependent cytokinesis (GO:0061640)2.00246855
182regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.99378228
183heterochromatin organization (GO:0070828)1.98425688
184protein dealkylation (GO:0008214)1.97274383
185protein demethylation (GO:0006482)1.97274383
186negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.97124953
187type B pancreatic cell development (GO:0003323)1.96358342
188histone lysine methylation (GO:0034968)1.96095886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.76254493
2EZH2_22144423_ChIP-Seq_EOC_Human3.73794836
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.68656659
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95231637
5E2F7_22180533_ChIP-Seq_HELA_Human2.80468430
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.75570666
7VDR_24763502_ChIP-Seq_THP-1_Human2.47648314
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47401450
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28895536
10MAF_26560356_Chip-Seq_TH1_Human2.15188846
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.02334410
12* UTX_26944678_Chip-Seq_JUKART_Human1.98271910
13EGR1_19374776_ChIP-ChIP_THP-1_Human1.98022651
14KDM2B_26808549_Chip-Seq_K562_Human1.94883614
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92999533
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90291270
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88782230
18LXR_22292898_ChIP-Seq_THP-1_Human1.87850545
19MAF_26560356_Chip-Seq_TH2_Human1.85723880
20KDM2B_26808549_Chip-Seq_DND41_Human1.82276821
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81714263
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77349965
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76768063
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75671379
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74821991
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.73176540
27* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72450800
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71143481
29CIITA_25753668_ChIP-Seq_RAJI_Human1.69735538
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67764784
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.67416530
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.65218641
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62060685
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60655983
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59062188
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58504693
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.57977132
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57631171
39CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.56652831
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54726710
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54639254
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.53690054
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.53478411
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53463585
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53319328
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51297068
47MYC_22102868_ChIP-Seq_BL_Human1.51285837
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50271553
49FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49719991
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49463453
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49463453
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49463453
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.49049797
54TCF7_22412390_ChIP-Seq_EML_Mouse1.48311425
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48294181
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48294181
57SPI1_23547873_ChIP-Seq_NB4_Human1.46802848
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46133312
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45790222
60RACK7_27058665_Chip-Seq_MCF-7_Human1.45056430
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44701384
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44598007
63* FOXM1_23109430_ChIP-Seq_U2OS_Human1.44499821
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43197942
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42174060
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41656627
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41101670
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.40999973
69NCOR1_26117541_ChIP-Seq_K562_Human1.39837718
70SCL_19346495_ChIP-Seq_HPC-7_Human1.38405800
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37014604
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35909712
73DROSHA_22980978_ChIP-Seq_HELA_Human1.35694552
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34199675
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33311703
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32681237
77P68_20966046_ChIP-Seq_HELA_Human1.32632351
78* MYB_26560356_Chip-Seq_TH1_Human1.31896149
79XRN2_22483619_ChIP-Seq_HELA_Human1.31745504
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.31387809
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30388098
82SPI1_23127762_ChIP-Seq_K562_Human1.28719806
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28634686
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26935666
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26431681
86* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25594034
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23693036
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21169896
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20599698
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20556568
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19181721
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18907580
93* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18695852
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18313083
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18111903
96* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16503883
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15374851
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15374851
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.15282636
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15070285
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14246430
102TFEB_21752829_ChIP-Seq_HELA_Human1.14006747
103MYB_26560356_Chip-Seq_TH2_Human1.13450597
104* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13012747
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12667126
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12248578
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12226782
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.11883873
109SMC4_20622854_ChIP-Seq_HELA_Human1.11311705
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10656148
111KDM5A_27292631_Chip-Seq_BREAST_Human1.08931140
112REST_21632747_ChIP-Seq_MESCs_Mouse1.08081792
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07069109
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.06243885
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06172040
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.06003061
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05691623
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05341877
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.05140897
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04634000
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04616013
122AR_19668381_ChIP-Seq_PC3_Human1.04218964
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04165263
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04108327
125BCOR_27268052_Chip-Seq_Bcells_Human1.03686428
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.03494745
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03284142
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02348273
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01837017
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01718859
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.01523826
132CREB1_26743006_Chip-Seq_LNCaP_Human1.01397742
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00808227
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00631397
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99936967
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99287975
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.98764831
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.98718402
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.98006831
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97862386
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97846194
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97389870
143* ATF3_27146783_Chip-Seq_COLON_Human0.97178973
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96603779
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.96545979
146IRF8_21731497_ChIP-ChIP_J774_Mouse0.96393077
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.95398339
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94965474
149CHD1_26751641_Chip-Seq_LNCaP_Human0.94932115
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93692705
151* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93619627
152* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93301619
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93254304
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.92659525
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.92473107
156STAT3_23295773_ChIP-Seq_U87_Human0.90567875
157AHR_22903824_ChIP-Seq_MCF-7_Human0.90477765
158RNF2_27304074_Chip-Seq_NSC_Mouse0.88996719
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88466708
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87767430
161ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85754777
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.84046220
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83996922
164CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83598165
165REST_18959480_ChIP-ChIP_MESCs_Mouse0.83534891
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83480175
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83345758
168NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83021962
169SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82771264
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82238718
171NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82106058
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.82090772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.25226914
2MP0004859_abnormal_synaptic_plasticity3.09070086
3MP0001849_ear_inflammation3.07961239
4MP0002009_preneoplasia2.84514281
5MP0005257_abnormal_intraocular_pressure2.84292182
6MP0000569_abnormal_digit_pigmentation2.64715096
7MP0003787_abnormal_imprinting2.54286549
8MP0003828_pulmonary_edema2.49001233
9MP0003724_increased_susceptibility_to2.28984034
10MP0004270_analgesia2.24960088
11MP0004858_abnormal_nervous_system2.11863337
12MP0002653_abnormal_ependyma_morphology2.11633930
13MP0008877_abnormal_DNA_methylation2.07584942
14MP0002419_abnormal_innate_immunity2.00546420
15MP0004808_abnormal_hematopoietic_stem1.94867904
16MP0004185_abnormal_adipocyte_glucose1.88317153
17MP0002132_abnormal_respiratory_system1.88038334
18MP0008789_abnormal_olfactory_epithelium1.87464569
19MP0008260_abnormal_autophagy1.87023773
20MP0002396_abnormal_hematopoietic_system1.76073456
21MP0003693_abnormal_embryo_hatching1.73268283
22MP0005397_hematopoietic_system_phenotyp1.72572467
23MP0001545_abnormal_hematopoietic_system1.72572467
24MP0003077_abnormal_cell_cycle1.72195651
25MP0001299_abnormal_eye_distance/1.69920516
26MP0003121_genomic_imprinting1.69154894
27MP0005499_abnormal_olfactory_system1.66848109
28MP0005394_taste/olfaction_phenotype1.66848109
29MP0003221_abnormal_cardiomyocyte_apopto1.66292614
30MP0005076_abnormal_cell_differentiation1.65668441
31MP0005623_abnormal_meninges_morphology1.63162104
32MP0003705_abnormal_hypodermis_morpholog1.61329814
33MP0003111_abnormal_nucleus_morphology1.61207852
34MP0008057_abnormal_DNA_replication1.60805954
35MP0005187_abnormal_penis_morphology1.59335504
36MP0000703_abnormal_thymus_morphology1.55983809
37MP0003123_paternal_imprinting1.53264377
38MP0002398_abnormal_bone_marrow1.51468972
39MP0002420_abnormal_adaptive_immunity1.47960311
40MP0008961_abnormal_basal_metabolism1.45997883
41MP0001800_abnormal_humoral_immune1.45978682
42MP0002277_abnormal_respiratory_mucosa1.45206939
43MP0009053_abnormal_anal_canal1.44972945
44MP0001819_abnormal_immune_cell1.44968813
45MP0001984_abnormal_olfaction1.43892001
46MP0000733_abnormal_muscle_development1.43198410
47MP0005423_abnormal_somatic_nervous1.41094587
48MP0000003_abnormal_adipose_tissue1.40976559
49MP0002734_abnormal_mechanical_nocicepti1.40397966
50MP0002184_abnormal_innervation1.40394337
51MP0004510_myositis1.38167785
52MP0003635_abnormal_synaptic_transmissio1.37498799
53MP0002452_abnormal_antigen_presenting1.37387904
54MP0005000_abnormal_immune_tolerance1.36885254
55MP0002723_abnormal_immune_serum1.35824515
56MP0010030_abnormal_orbit_morphology1.34691167
57MP0001346_abnormal_lacrimal_gland1.32389513
58MP0005410_abnormal_fertilization1.32352206
59MP0001835_abnormal_antigen_presentation1.32131973
60MP0009250_abnormal_appendicular_skeleto1.31883019
61MP0003861_abnormal_nervous_system1.30076361
62MP0000750_abnormal_muscle_regeneration1.29683386
63MP0005025_abnormal_response_to1.29608758
64MP0003385_abnormal_body_wall1.28054500
65MP0003300_gastrointestinal_ulcer1.27086926
66MP0002084_abnormal_developmental_patter1.27016886
67MP0000778_abnormal_nervous_system1.24652913
68MP0000716_abnormal_immune_system1.24485483
69MP0009672_abnormal_birth_weight1.24324741
70MP0000566_synostosis1.23340568
71MP0002722_abnormal_immune_system1.21874958
72MP0000685_abnormal_immune_system1.21683624
73MP0003172_abnormal_lysosome_physiology1.21562229
74MP0010630_abnormal_cardiac_muscle1.21232286
75MP0005451_abnormal_body_composition1.20503221
76MP0005645_abnormal_hypothalamus_physiol1.20396251
77MP0002163_abnormal_gland_morphology1.18774356
78MP0002405_respiratory_system_inflammati1.16846614
79MP0003656_abnormal_erythrocyte_physiolo1.16760864
80MP0002102_abnormal_ear_morphology1.13434788
81MP0002233_abnormal_nose_morphology1.13431308
82MP0002210_abnormal_sex_determination1.12939460
83MP0002085_abnormal_embryonic_tissue1.12544100
84MP0000428_abnormal_craniofacial_morphol1.12252549
85MP0003698_abnormal_male_reproductive1.11592325
86MP0002063_abnormal_learning/memory/cond1.10911268
87MP0004811_abnormal_neuron_physiology1.10479349
88MP0003937_abnormal_limbs/digits/tail_de1.10048993
89MP0003303_peritoneal_inflammation1.09730921
90MP0002429_abnormal_blood_cell1.09459781
91MP0005310_abnormal_salivary_gland1.09148925
92MP0000313_abnormal_cell_death1.09001165
93MP0002249_abnormal_larynx_morphology1.08447132
94MP0002877_abnormal_melanocyte_morpholog1.08299166
95MP0001929_abnormal_gametogenesis1.07423336
96MP0002152_abnormal_brain_morphology1.07312634
97MP0003763_abnormal_thymus_physiology1.07109825
98MP0000534_abnormal_ureter_morphology1.06982287
99MP0003942_abnormal_urinary_system1.06979601
100MP0003122_maternal_imprinting1.06388108
101MP0004130_abnormal_muscle_cell1.05352372
102MP0002882_abnormal_neuron_morphology1.05156516
103MP0003755_abnormal_palate_morphology1.04938980
104MP0003935_abnormal_craniofacial_develop1.04484850
105MP0002116_abnormal_craniofacial_bone1.04315054
106MP0000747_muscle_weakness1.04253053
107MP0001533_abnormal_skeleton_physiology1.02876555
108MP0004885_abnormal_endolymph1.02231209
109MP0009840_abnormal_foam_cell1.02044509
110MP0009278_abnormal_bone_marrow1.02039570
111MP0000759_abnormal_skeletal_muscle1.00895396
112MP0001672_abnormal_embryogenesis/_devel1.00196330
113MP0005380_embryogenesis_phenotype1.00196330
114MP0002998_abnormal_bone_remodeling0.99984695
115MP0000689_abnormal_spleen_morphology0.99713908
116MP0010352_gastrointestinal_tract_polyps0.99667643
117MP0010307_abnormal_tumor_latency0.99527928
118MP0003646_muscle_fatigue0.98720878
119MP0005503_abnormal_tendon_morphology0.98648540
120MP0005058_abnormal_lysosome_morphology0.98611228
121MP0002332_abnormal_exercise_endurance0.98441985
122MP0009333_abnormal_splenocyte_physiolog0.97651339
123MP0004197_abnormal_fetal_growth/weight/0.96887258
124MP0002161_abnormal_fertility/fecundity0.95591271
125MP0004947_skin_inflammation0.94739437
126MP0000653_abnormal_sex_gland0.94667333
127MP0004233_abnormal_muscle_weight0.94148985
128MP0001730_embryonic_growth_arrest0.92067164
129MP0005387_immune_system_phenotype0.91004223
130MP0001790_abnormal_immune_system0.91004223
131MP0000955_abnormal_spinal_cord0.90623834
132MP0003091_abnormal_cell_migration0.89187413
133MP0000432_abnormal_head_morphology0.88194027
134MP0001486_abnormal_startle_reflex0.87993687
135MP0000049_abnormal_middle_ear0.87817031
136MP0001851_eye_inflammation0.86105339
137MP0003699_abnormal_female_reproductive0.85709657
138MP0000678_abnormal_parathyroid_gland0.85427441
139MP0004087_abnormal_muscle_fiber0.85294302
140MP0002109_abnormal_limb_morphology0.84303524
141MP0001348_abnormal_lacrimal_gland0.84130970
142MP0000631_abnormal_neuroendocrine_gland0.83811462
143MP0001293_anophthalmia0.83438683
144MP0002092_abnormal_eye_morphology0.82315391
145MP0002932_abnormal_joint_morphology0.81954681
146MP0002925_abnormal_cardiovascular_devel0.81640826
147MP0004381_abnormal_hair_follicle0.81498597
148MP0010368_abnormal_lymphatic_system0.80851492
149MP0002080_prenatal_lethality0.80582447
150MP0000537_abnormal_urethra_morphology0.80213360
151MP0000490_abnormal_crypts_of0.80172280
152MP0001145_abnormal_male_reproductive0.80146059
153MP0001697_abnormal_embryo_size0.80058887
154MP0000350_abnormal_cell_proliferation0.78388173
155MP0001485_abnormal_pinna_reflex0.78254749
156MP0002752_abnormal_somatic_nervous0.76802843
157MP0008438_abnormal_cutaneous_collagen0.75351419
158MP0002114_abnormal_axial_skeleton0.75071224
159MP0001915_intracranial_hemorrhage0.75042382
160MP0002697_abnormal_eye_size0.74911885
161MP0003984_embryonic_growth_retardation0.74260333
162MP0002088_abnormal_embryonic_growth/wei0.74124450
163MP0003878_abnormal_ear_physiology0.73738715
164MP0005377_hearing/vestibular/ear_phenot0.73738715
165MP0005409_darkened_coat_color0.72366873
166MP0003890_abnormal_embryonic-extraembry0.70311270
167MP0005621_abnormal_cell_physiology0.70092582
168MP0005390_skeleton_phenotype0.68275636
169MP0002166_altered_tumor_susceptibility0.67819999
170MP0003191_abnormal_cellular_cholesterol0.66989014
171MP0002822_catalepsy0.66278521
172MP0009115_abnormal_fat_cell0.65745580
173MP0002269_muscular_atrophy0.65397316

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.42778156
2Eczematoid dermatitis (HP:0000976)3.27480259
3Recurrent abscess formation (HP:0002722)3.22510188
4Recurrent bacterial skin infections (HP:0005406)3.09371988
5Myositis (HP:0100614)3.07003053
6Orchitis (HP:0100796)2.95996427
7Abnormality of the columella (HP:0009929)2.92848584
8Broad distal phalanx of finger (HP:0009836)2.91480512
9Abnormality of macrophages (HP:0004311)2.88146136
10Male infertility (HP:0003251)2.87665465
11Hyperacusis (HP:0010780)2.84640005
12Papillary thyroid carcinoma (HP:0002895)2.80725977
13Difficulty running (HP:0009046)2.76386980
14Hypochromic anemia (HP:0001931)2.69644557
15Optic neuritis (HP:0100653)2.67573699
16Retrobulbar optic neuritis (HP:0100654)2.67573699
17Segmental peripheral demyelination/remyelination (HP:0003481)2.65745418
18Renal duplication (HP:0000075)2.63105424
19Deep palmar crease (HP:0006191)2.57034542
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53508743
21Short 4th metacarpal (HP:0010044)2.53508743
22Mediastinal lymphadenopathy (HP:0100721)2.52309987
23Obstructive lung disease (HP:0006536)2.49776120
24Chronic obstructive pulmonary disease (HP:0006510)2.49776120
25Vertebral arch anomaly (HP:0008438)2.49378721
26Genu recurvatum (HP:0002816)2.48854167
27Abnormality of the fingertips (HP:0001211)2.48432620
28Cellulitis (HP:0100658)2.48285346
29Stomatitis (HP:0010280)2.44261915
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.43235569
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.43126638
32Renovascular hypertension (HP:0100817)2.42257099
33Overriding aorta (HP:0002623)2.41849205
34Insomnia (HP:0100785)2.36691209
35Gastrointestinal infarctions (HP:0005244)2.35813643
36Slow saccadic eye movements (HP:0000514)2.32406836
37Increased IgE level (HP:0003212)2.31469212
38Genetic anticipation (HP:0003743)2.31132566
39Progressive muscle weakness (HP:0003323)2.29871417
40Abnormality of the diencephalon (HP:0010662)2.26623908
41Hypochromic microcytic anemia (HP:0004840)2.25601277
42Shallow orbits (HP:0000586)2.21245183
43Neonatal hypoglycemia (HP:0001998)2.20583065
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19624456
45Metaphyseal cupping (HP:0003021)2.16599703
46Anosmia (HP:0000458)2.16389369
47Spinal cord lesions (HP:0100561)2.16072906
48Syringomyelia (HP:0003396)2.16072906
49Meningitis (HP:0001287)2.12338762
50Bowel incontinence (HP:0002607)2.12086924
51Chest pain (HP:0100749)2.12020587
52Dysmetric saccades (HP:0000641)2.11495502
53Heterotopia (HP:0002282)2.11048118
54Trigonocephaly (HP:0000243)2.10396750
55Macroorchidism (HP:0000053)2.09000837
56Narrow palate (HP:0000189)2.08571386
57Elfin facies (HP:0004428)2.08503640
58Gastrointestinal inflammation (HP:0004386)2.08423971
59Abnormal large intestine physiology (HP:0012700)2.08009101
60Recurrent fungal infections (HP:0002841)2.05646247
61Muscle fiber splitting (HP:0003555)2.05096724
62Long palpebral fissure (HP:0000637)2.03742165
63Myopathic facies (HP:0002058)2.03637465
64Exercise-induced myalgia (HP:0003738)2.03635088
65Subaortic stenosis (HP:0001682)2.02690408
66Abnormality of the left ventricular outflow tract (HP:0011103)2.02690408
67Abnormality of the intervertebral disk (HP:0005108)2.01785790
68Spontaneous hematomas (HP:0007420)2.01059499
69Obstructive sleep apnea (HP:0002870)1.99415696
70Colitis (HP:0002583)1.99336618
71Arterial tortuosity (HP:0005116)1.98882486
72Facial hemangioma (HP:0000329)1.98441298
73Lip pit (HP:0100267)1.97826103
74Abnormality of the 4th metacarpal (HP:0010012)1.96309078
75Bladder diverticulum (HP:0000015)1.94297947
76Sacral dimple (HP:0000960)1.94034598
77Inflammation of the large intestine (HP:0002037)1.90937223
78Gingivitis (HP:0000230)1.90567636
79Shawl scrotum (HP:0000049)1.90410081
80Apathy (HP:0000741)1.90333133
81Cerebral aneurysm (HP:0004944)1.89545920
82Abnormality of the phalanges of the hallux (HP:0010057)1.89164993
83Ectopic kidney (HP:0000086)1.89112802
84Papilledema (HP:0001085)1.88929143
85Progressive external ophthalmoplegia (HP:0000590)1.87792880
86Midline defect of the nose (HP:0004122)1.87669477
87Recurrent cutaneous fungal infections (HP:0011370)1.87111677
88Chronic mucocutaneous candidiasis (HP:0002728)1.87111677
89Increased variability in muscle fiber diameter (HP:0003557)1.84086551
90Supernumerary ribs (HP:0005815)1.83311088
91Abnormality of skeletal muscle fiber size (HP:0012084)1.82915106
92Rectal prolapse (HP:0002035)1.82800436
93Viral hepatitis (HP:0006562)1.82796856
94Flat cornea (HP:0007720)1.82490433
95Broad thumb (HP:0011304)1.82447527
96Urticaria (HP:0001025)1.82279635
97Recurrent gram-negative bacterial infections (HP:0005420)1.81439235
98Ulnar bowing (HP:0003031)1.80759080
99Recurrent skin infections (HP:0001581)1.80233331
100Elevated erythrocyte sedimentation rate (HP:0003565)1.79025918
101Germ cell neoplasia (HP:0100728)1.78893722
102Abnormality of the parietal bone (HP:0002696)1.78821094
103EMG: myopathic abnormalities (HP:0003458)1.77775520
104Keratoconjunctivitis sicca (HP:0001097)1.77540110
105Encephalitis (HP:0002383)1.77457696
106Vascular tortuosity (HP:0004948)1.77393521
107Abnormality of the calcaneus (HP:0008364)1.77231330
108Spina bifida occulta (HP:0003298)1.76929657
109Episodic fever (HP:0001954)1.76537855
110Pendular nystagmus (HP:0012043)1.76335316
111Termporal pattern (HP:0011008)1.75979472
112Insidious onset (HP:0003587)1.75979472
113Pointed chin (HP:0000307)1.74821681
114Abnormality of the incisor (HP:0000676)1.74462734
115Unilateral renal agenesis (HP:0000122)1.74349561
116Broad palm (HP:0001169)1.73951103
117Acute lymphatic leukemia (HP:0006721)1.73425173
118Hypercortisolism (HP:0001578)1.73102938
119Abnormality of incisor morphology (HP:0011063)1.72686543
120Myokymia (HP:0002411)1.71814123
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.71006091
122Broad finger (HP:0001500)1.70681908
123Dislocated radial head (HP:0003083)1.70548821
124Bowel diverticulosis (HP:0005222)1.69994615
125Abnormality of the endocardium (HP:0004306)1.69740194
126Oligodontia (HP:0000677)1.69688569
127Aortic aneurysm (HP:0004942)1.69167495
128Abnormality of macular pigmentation (HP:0008002)1.68596691
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.68555573
130Absent/shortened dynein arms (HP:0200106)1.68555573
131Thyroid carcinoma (HP:0002890)1.68294572
132Ulnar claw (HP:0001178)1.66720738
133Long eyelashes (HP:0000527)1.66639135
134Bicuspid aortic valve (HP:0001647)1.66120345
135Increased nuchal translucency (HP:0010880)1.65709852
136Deviation of the hallux (HP:0010051)1.64814275
137Breast aplasia (HP:0100783)1.64466796
138Molar tooth sign on MRI (HP:0002419)1.64215765
139Abnormality of midbrain morphology (HP:0002418)1.64215765
140Fatigue (HP:0012378)1.64197659
141Dental malocclusion (HP:0000689)1.64151569
142Urinary bladder sphincter dysfunction (HP:0002839)1.63971812
143Onion bulb formation (HP:0003383)1.63840828
144Patellar dislocation (HP:0002999)1.62978007
145Decreased motor nerve conduction velocity (HP:0003431)1.62553237
146High anterior hairline (HP:0009890)1.62526411
147Difficulty climbing stairs (HP:0003551)1.62491933
148Hallux valgus (HP:0001822)1.61705639
149Neoplasm of the oral cavity (HP:0100649)1.61297460
150Diminished motivation (HP:0000745)1.61283506
151Widely spaced teeth (HP:0000687)1.60921454
152Arterial thrombosis (HP:0004420)1.60805329
153Supranuclear gaze palsy (HP:0000605)1.60203370
154Striae distensae (HP:0001065)1.59743732
155Protrusio acetabuli (HP:0003179)1.59306551
156Broad face (HP:0000283)1.58834457
157Abnormality of the radial head (HP:0003995)1.58216815
158Muscle fiber inclusion bodies (HP:0100299)1.57731936
159Abnormal number of incisors (HP:0011064)1.57197580
160Peripheral hypomyelination (HP:0007182)1.57196680
161Calcaneovalgus deformity (HP:0001848)1.56707777
162Abnormality of the aortic arch (HP:0012303)1.55922895
163Aplasia/Hypoplasia of the breasts (HP:0010311)1.53856402
164Aortic dissection (HP:0002647)1.53564023
165Large eyes (HP:0001090)1.52973732
166Abnormal respiratory motile cilium physiology (HP:0012261)1.52110797
167Spondylolisthesis (HP:0003302)1.51940669
168Erectile abnormalities (HP:0100639)1.51526960
169Sparse lateral eyebrow (HP:0005338)1.48547784
170Atonic seizures (HP:0010819)1.47235101
171Uterine leiomyosarcoma (HP:0002891)1.46486298
172Leiomyosarcoma (HP:0100243)1.46486298
173Megalocornea (HP:0000485)1.46097929
174Abnormality of the labia minora (HP:0012880)1.45555156
175Visual hallucinations (HP:0002367)1.45498703
176Neoplasm of the heart (HP:0100544)1.45244515
177Broad phalanges of the hand (HP:0009768)1.43696724
178Pelvic girdle muscle weakness (HP:0003749)1.43398482
179Choroideremia (HP:0001139)1.43166059
180Transitional cell carcinoma of the bladder (HP:0006740)1.42955659
181Truncal obesity (HP:0001956)1.42326132
182Bundle branch block (HP:0011710)1.41652507
183Inappropriate behavior (HP:0000719)1.41376375
184Gynecomastia (HP:0000771)1.40933410
185Nephronophthisis (HP:0000090)1.40427466
186Absent eyebrow (HP:0002223)1.40267809
187Subacute progressive viral hepatitis (HP:0006572)1.40218383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.20603554
2LATS24.26317466
3CDK123.43024818
4TAOK13.11834279
5MAP2K32.96730408
6PRKD32.87288672
7EEF2K2.76798884
8MAP3K92.59406931
9RIPK42.58540021
10IRAK42.55813090
11STK38L2.55015717
12BRD42.49687490
13SMG12.43051749
14PAK62.27888907
15KSR22.04715771
16STK381.99606689
17TRIB31.97862042
18ICK1.76603154
19CDC71.73926755
20CDK191.73605846
21STK31.72367187
22TNK21.62390745
23SIK21.61180143
24CDK81.53523556
25MAP3K61.52557445
26IRAK11.51821641
27MAP4K11.50122800
28IRAK21.42118387
29TYRO31.41291581
30MAP3K111.39728466
31DMPK1.38824622
32PLK41.38811241
33TAOK21.38362899
34MAP3K31.38301943
35ARAF1.35766735
36RAF11.31764381
37ERBB41.29211727
38NEK21.28381080
39MARK21.21472528
40ERBB31.21323311
41BMPR21.18997329
42RET1.13804275
43MAP3K101.12798059
44SIK31.11895606
45DYRK1B1.07535016
46FES1.07297114
47KSR11.06291140
48MAP3K41.04945515
49CAMK1G1.03883967
50RPS6KC11.03509257
51RPS6KL11.03509257
52DYRK31.01436059
53MTOR1.00826548
54HCK0.97875778
55NTRK20.92780607
56BLK0.92653280
57MAP3K70.91942036
58PRKD20.90739173
59PAK30.90141376
60ALK0.89753358
61RPS6KA60.88441043
62PLK20.87984394
63CSK0.85360340
64ZAP700.84784232
65JAK20.83420565
66MAPK130.83179550
67PRPF4B0.82575239
68PRKCH0.81752786
69TBK10.80968354
70PKN20.80948931
71CAMK40.80197887
72CAMK1D0.79817752
73* RPS6KA10.78195591
74PDGFRB0.78006924
75PTK60.76813402
76NTRK30.76590525
77CDK40.75191757
78BTK0.75063522
79WNK10.74762500
80MINK10.73475497
81IRAK30.72710832
82CDK70.72332133
83EPHB10.72244377
84MAP2K20.72200638
85CHEK20.71411733
86PDGFRA0.70565730
87NTRK10.70457622
88GRK60.68626788
89TYK20.68265906
90YES10.67552924
91MAPK120.66998829
92TTN0.66827826
93MAP3K130.66685948
94BRAF0.66592443
95DDR20.65737593
96EPHA30.64125320
97MAP3K80.63551529
98CSNK1G20.63482766
99EPHB20.63337785
100CLK10.63118336
101MAPK100.62711722
102MAP3K140.62627176
103PIM10.62013933
104FGFR30.61480186
105BMX0.60374113
106SIK10.60209449
107RIPK10.60017093
108IKBKE0.59446204
109FGR0.58593951
110MAP2K40.58501622
111HIPK20.56424052
112MARK30.54911590
113DAPK20.54498050
114NUAK10.54431788
115STK110.53211172
116TTK0.49760599
117PAK20.47398915
118MELK0.46596528
119CAMKK10.46304988
120PTK2B0.46089363
121MAPKAPK30.45282128
122AKT10.45079211
123SGK20.44423304
124MARK10.44292977
125CSNK1A1L0.44290966
126MAP3K20.44154542
127MOS0.43593264
128STK160.43228287
129CHEK10.42977534
130UHMK10.42870130
131CSNK1D0.42797671
132CHUK0.42675990
133CDC42BPA0.42535518
134PASK0.42259713
135MAP3K10.42203573
136RPS6KA20.42034680
137CDK90.41758372
138CDK60.40860887
139SGK30.40699713
140SGK2230.40440483
141SGK4940.40440483
142CSNK1E0.40228982
143ERN10.38963004
144DYRK20.38183800
145MAPK70.38056021
146LRRK20.37868711
147GSK3B0.35888039
148CDK20.35866947
149TAOK30.34974437
150MAPK110.33821994
151CDK50.32845592
152CSNK1G10.30578314
153MAPK140.30550148
154PDPK10.30515261
155PRKAA10.30250509
156ATM0.30238922
157PDK10.30225174
158MAP3K50.30026448
159PTK20.29161903

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.08551847
2Osteoclast differentiation_Homo sapiens_hsa043802.04924924
3Leishmaniasis_Homo sapiens_hsa051401.76754634
4Dorso-ventral axis formation_Homo sapiens_hsa043201.66482149
5Chronic myeloid leukemia_Homo sapiens_hsa052201.64287344
6mTOR signaling pathway_Homo sapiens_hsa041501.61615507
7Renal cell carcinoma_Homo sapiens_hsa052111.58300338
8Pancreatic cancer_Homo sapiens_hsa052121.55184424
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54287159
10Glioma_Homo sapiens_hsa052141.54027200
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48830868
12Endometrial cancer_Homo sapiens_hsa052131.43067455
13Colorectal cancer_Homo sapiens_hsa052101.41250923
14Non-small cell lung cancer_Homo sapiens_hsa052231.33727304
15ErbB signaling pathway_Homo sapiens_hsa040121.32741961
16Tuberculosis_Homo sapiens_hsa051521.31963255
17Influenza A_Homo sapiens_hsa051641.30882459
18Apoptosis_Homo sapiens_hsa042101.30043049
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29952426
20VEGF signaling pathway_Homo sapiens_hsa043701.28441300
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.28110048
22Prolactin signaling pathway_Homo sapiens_hsa049171.27809280
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27782096
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24720568
25Legionellosis_Homo sapiens_hsa051341.24484233
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23940288
27Synaptic vesicle cycle_Homo sapiens_hsa047211.23281597
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23126775
29Estrogen signaling pathway_Homo sapiens_hsa049151.22503144
30Notch signaling pathway_Homo sapiens_hsa043301.19184056
31Cholinergic synapse_Homo sapiens_hsa047251.18901405
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18635728
33GnRH signaling pathway_Homo sapiens_hsa049121.18466024
34Long-term potentiation_Homo sapiens_hsa047201.17324366
35Type II diabetes mellitus_Homo sapiens_hsa049301.13657517
36Herpes simplex infection_Homo sapiens_hsa051681.12967126
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12031243
38Circadian entrainment_Homo sapiens_hsa047131.11023909
39Measles_Homo sapiens_hsa051621.10927168
40Dopaminergic synapse_Homo sapiens_hsa047281.10642766
41Oocyte meiosis_Homo sapiens_hsa041141.10407099
42MicroRNAs in cancer_Homo sapiens_hsa052061.09654076
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08147603
44Viral carcinogenesis_Homo sapiens_hsa052031.07722602
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06974890
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06467229
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06449912
48Hippo signaling pathway_Homo sapiens_hsa043901.06225539
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05370972
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02711268
51Morphine addiction_Homo sapiens_hsa050320.99727842
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99517019
53Glutamatergic synapse_Homo sapiens_hsa047240.99501805
54Phototransduction_Homo sapiens_hsa047440.99285794
55Oxytocin signaling pathway_Homo sapiens_hsa049210.98648286
56Adherens junction_Homo sapiens_hsa045200.97980865
57Basal transcription factors_Homo sapiens_hsa030220.97810222
58cAMP signaling pathway_Homo sapiens_hsa040240.96697052
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96666954
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96521342
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95638772
62Inositol phosphate metabolism_Homo sapiens_hsa005620.95525653
63Insulin secretion_Homo sapiens_hsa049110.95409156
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94698691
65TGF-beta signaling pathway_Homo sapiens_hsa043500.94186960
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.93819957
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93779364
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93722612
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92859184
70Hepatitis C_Homo sapiens_hsa051600.92386210
71Axon guidance_Homo sapiens_hsa043600.92179239
72Wnt signaling pathway_Homo sapiens_hsa043100.91959640
73Choline metabolism in cancer_Homo sapiens_hsa052310.91946142
74MAPK signaling pathway_Homo sapiens_hsa040100.91869872
75Proteoglycans in cancer_Homo sapiens_hsa052050.91788028
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91375323
77mRNA surveillance pathway_Homo sapiens_hsa030150.91164600
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.90360817
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89950898
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89046650
81Thyroid cancer_Homo sapiens_hsa052160.88249581
82Ras signaling pathway_Homo sapiens_hsa040140.87760715
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87548346
84Prostate cancer_Homo sapiens_hsa052150.86906218
85Ovarian steroidogenesis_Homo sapiens_hsa049130.86799636
86GABAergic synapse_Homo sapiens_hsa047270.85860129
87Gastric acid secretion_Homo sapiens_hsa049710.85011294
88Long-term depression_Homo sapiens_hsa047300.84688719
89Malaria_Homo sapiens_hsa051440.84000236
90Acute myeloid leukemia_Homo sapiens_hsa052210.83425129
91Focal adhesion_Homo sapiens_hsa045100.83414148
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.83158789
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.83126037
94Melanoma_Homo sapiens_hsa052180.83116719
95Epstein-Barr virus infection_Homo sapiens_hsa051690.83107538
96TNF signaling pathway_Homo sapiens_hsa046680.82903408
97FoxO signaling pathway_Homo sapiens_hsa040680.82856025
98Melanogenesis_Homo sapiens_hsa049160.82275067
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82195661
100Hepatitis B_Homo sapiens_hsa051610.82049801
101Rap1 signaling pathway_Homo sapiens_hsa040150.81969382
102Hedgehog signaling pathway_Homo sapiens_hsa043400.79910998
103Chemokine signaling pathway_Homo sapiens_hsa040620.79833981
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78952078
105Small cell lung cancer_Homo sapiens_hsa052220.78789595
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.78215194
107Tight junction_Homo sapiens_hsa045300.77722293
108Salivary secretion_Homo sapiens_hsa049700.77504216
109Cell cycle_Homo sapiens_hsa041100.77405501
110Gap junction_Homo sapiens_hsa045400.77203013
111Endocytosis_Homo sapiens_hsa041440.76621529
112Shigellosis_Homo sapiens_hsa051310.76187243
113HIF-1 signaling pathway_Homo sapiens_hsa040660.75588169
114Basal cell carcinoma_Homo sapiens_hsa052170.75271733
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.74479212
116B cell receptor signaling pathway_Homo sapiens_hsa046620.73812763
117T cell receptor signaling pathway_Homo sapiens_hsa046600.73589807
118Spliceosome_Homo sapiens_hsa030400.73520812
119Other glycan degradation_Homo sapiens_hsa005110.73502265
120Amphetamine addiction_Homo sapiens_hsa050310.73240124
121Insulin signaling pathway_Homo sapiens_hsa049100.72770377
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71928313
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71833088
124AMPK signaling pathway_Homo sapiens_hsa041520.71395634
125Bladder cancer_Homo sapiens_hsa052190.70361511
126Dilated cardiomyopathy_Homo sapiens_hsa054140.70130709
127Toxoplasmosis_Homo sapiens_hsa051450.69518150
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.69503832
129Amoebiasis_Homo sapiens_hsa051460.69462452
130Insulin resistance_Homo sapiens_hsa049310.69427180
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68170529
132Pathways in cancer_Homo sapiens_hsa052000.67953433
133HTLV-I infection_Homo sapiens_hsa051660.66789458
134Viral myocarditis_Homo sapiens_hsa054160.66290980
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65441730
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.65158049
137Regulation of autophagy_Homo sapiens_hsa041400.58787869
138p53 signaling pathway_Homo sapiens_hsa041150.54495942
139Phagosome_Homo sapiens_hsa041450.54333373
140African trypanosomiasis_Homo sapiens_hsa051430.52221164
141Salmonella infection_Homo sapiens_hsa051320.52019074
142Platelet activation_Homo sapiens_hsa046110.50198337
143Staphylococcus aureus infection_Homo sapiens_hsa051500.50178081

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