

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore organization (GO:0006999) | 4.40866164 |
| 2 | IMP biosynthetic process (GO:0006188) | 4.36853809 |
| 3 | mitotic metaphase plate congression (GO:0007080) | 4.30410460 |
| 4 | kinetochore organization (GO:0051383) | 4.26814450 |
| 5 | pre-miRNA processing (GO:0031054) | 4.26663903 |
| 6 | CENP-A containing nucleosome assembly (GO:0034080) | 4.26140203 |
| 7 | chromatin remodeling at centromere (GO:0031055) | 4.21563205 |
| 8 | nuclear pore complex assembly (GO:0051292) | 4.14974622 |
| 9 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.06822077 |
| 10 | DNA replication initiation (GO:0006270) | 3.99294259 |
| 11 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.95347698 |
| 12 | metaphase plate congression (GO:0051310) | 3.93561458 |
| 13 | establishment of viral latency (GO:0019043) | 3.93526548 |
| 14 | DNA strand elongation (GO:0022616) | 3.92095270 |
| 15 | nucleobase biosynthetic process (GO:0046112) | 3.88164647 |
| 16 | purine nucleobase biosynthetic process (GO:0009113) | 3.86813794 |
| 17 | kinetochore assembly (GO:0051382) | 3.85860485 |
| 18 | protein localization to kinetochore (GO:0034501) | 3.85691661 |
| 19 | heterochromatin organization (GO:0070828) | 3.80964895 |
| 20 | ribosomal small subunit assembly (GO:0000028) | 3.79869951 |
| 21 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.75767455 |
| 22 | DNA replication-independent nucleosome organization (GO:0034724) | 3.75767455 |
| 23 | telomere maintenance via recombination (GO:0000722) | 3.74781500 |
| 24 | establishment of chromosome localization (GO:0051303) | 3.69332753 |
| 25 | DNA unwinding involved in DNA replication (GO:0006268) | 3.66787346 |
| 26 | mitotic recombination (GO:0006312) | 3.64688123 |
| 27 | DNA replication checkpoint (GO:0000076) | 3.63851893 |
| 28 | non-recombinational repair (GO:0000726) | 3.62031387 |
| 29 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.62031387 |
| 30 | IMP metabolic process (GO:0046040) | 3.58795393 |
| 31 | regulation of gene silencing by RNA (GO:0060966) | 3.56328075 |
| 32 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.56328075 |
| 33 | regulation of gene silencing by miRNA (GO:0060964) | 3.56328075 |
| 34 | mitotic nuclear envelope disassembly (GO:0007077) | 3.55894226 |
| 35 | L-serine metabolic process (GO:0006563) | 3.53711445 |
| 36 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.51755139 |
| 37 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.51070371 |
| 38 | ribosome assembly (GO:0042255) | 3.47806512 |
| 39 | histone exchange (GO:0043486) | 3.47512696 |
| 40 | meiotic chromosome segregation (GO:0045132) | 3.43550568 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.43236426 |
| 42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.43236426 |
| 43 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.40291443 |
| 44 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.40291443 |
| 45 | DNA damage response, detection of DNA damage (GO:0042769) | 3.38423229 |
| 46 | telomere maintenance via telomere lengthening (GO:0010833) | 3.35087478 |
| 47 | pore complex assembly (GO:0046931) | 3.34080783 |
| 48 | regulation of chromosome segregation (GO:0051983) | 3.31010620 |
| 49 | mitotic chromosome condensation (GO:0007076) | 3.29330136 |
| 50 | protein localization to chromosome, centromeric region (GO:0071459) | 3.28111876 |
| 51 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.25878033 |
| 52 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.25878033 |
| 53 | negative regulation of DNA recombination (GO:0045910) | 3.25461729 |
| 54 | regulation of helicase activity (GO:0051095) | 3.25423494 |
| 55 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.24257511 |
| 56 | ribosome biogenesis (GO:0042254) | 3.23557822 |
| 57 | membrane disassembly (GO:0030397) | 3.22770667 |
| 58 | nuclear envelope disassembly (GO:0051081) | 3.22770667 |
| 59 | protein K6-linked ubiquitination (GO:0085020) | 3.22368827 |
| 60 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.19050909 |
| 61 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.19050909 |
| 62 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.19050909 |
| 63 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.17947910 |
| 64 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.17896647 |
| 65 | mitotic sister chromatid cohesion (GO:0007064) | 3.16670463 |
| 66 | ATP-dependent chromatin remodeling (GO:0043044) | 3.13885235 |
| 67 | response to X-ray (GO:0010165) | 3.13441065 |
| 68 | spindle checkpoint (GO:0031577) | 3.12561442 |
| 69 | viral mRNA export from host cell nucleus (GO:0046784) | 3.11779009 |
| 70 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.11326209 |
| 71 | formation of translation preinitiation complex (GO:0001731) | 3.10189238 |
| 72 | protein complex localization (GO:0031503) | 3.09478254 |
| 73 | mismatch repair (GO:0006298) | 3.09422707 |
| 74 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.06814571 |
| 75 | negative regulation of mitosis (GO:0045839) | 3.06210925 |
| 76 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.06162331 |
| 77 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.05273723 |
| 78 | maturation of SSU-rRNA (GO:0030490) | 3.05234326 |
| 79 | DNA topological change (GO:0006265) | 3.05187276 |
| 80 | spliceosomal snRNP assembly (GO:0000387) | 3.04672427 |
| 81 | RNA-dependent DNA replication (GO:0006278) | 3.04193852 |
| 82 | mitotic G2/M transition checkpoint (GO:0044818) | 2.98100147 |
| 83 | regulation of centriole replication (GO:0046599) | 2.96695961 |
| 84 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.96025626 |
| 85 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.96025626 |
| 86 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.96025626 |
| 87 | negative regulation of sister chromatid segregation (GO:0033046) | 2.96025626 |
| 88 | telomere maintenance (GO:0000723) | 2.95442415 |
| 89 | regulation of centrosome cycle (GO:0046605) | 2.93770252 |
| 90 | regulation of spindle organization (GO:0090224) | 2.93587540 |
| 91 | negative regulation of chromosome segregation (GO:0051985) | 2.93530362 |
| 92 | telomere organization (GO:0032200) | 2.93469496 |
| 93 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.92324195 |
| 94 | spindle assembly checkpoint (GO:0071173) | 2.91983271 |
| 95 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.91102214 |
| 96 | mitotic spindle checkpoint (GO:0071174) | 2.90050114 |
| 97 | mitotic sister chromatid segregation (GO:0000070) | 2.90022175 |
| 98 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.89642372 |
| 99 | transcription from RNA polymerase I promoter (GO:0006360) | 2.88956680 |
| 100 | telomere maintenance via telomerase (GO:0007004) | 2.87971966 |
| 101 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.87802980 |
| 102 | proteasome assembly (GO:0043248) | 2.87762522 |
| 103 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.86806293 |
| 104 | DNA strand renaturation (GO:0000733) | 2.84798943 |
| 105 | mitotic spindle assembly checkpoint (GO:0007094) | 2.84633669 |
| 106 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.84133317 |
| 107 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.84090079 |
| 108 | cullin deneddylation (GO:0010388) | 2.84038116 |
| 109 | DNA double-strand break processing (GO:0000729) | 2.83662710 |
| 110 | chromatin assembly or disassembly (GO:0006333) | 2.83545190 |
| 111 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.83018752 |
| 112 | negative regulation of ligase activity (GO:0051352) | 2.82338744 |
| 113 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.82338744 |
| 114 | establishment of integrated proviral latency (GO:0075713) | 2.82306412 |
| 115 | DNA ligation (GO:0006266) | 2.81652340 |
| 116 | lysine metabolic process (GO:0006553) | 2.81450062 |
| 117 | lysine catabolic process (GO:0006554) | 2.81450062 |
| 118 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.81006452 |
| 119 | ribosomal large subunit biogenesis (GO:0042273) | 2.80626879 |
| 120 | regulation of sister chromatid segregation (GO:0033045) | 2.80341183 |
| 121 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.80341183 |
| 122 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.80341183 |
| 123 | DNA geometric change (GO:0032392) | 2.78425059 |
| 124 | DNA duplex unwinding (GO:0032508) | 2.78400609 |
| 125 | histone H2A acetylation (GO:0043968) | 2.77178712 |
| 126 | termination of RNA polymerase I transcription (GO:0006363) | 2.75069126 |
| 127 | paraxial mesoderm development (GO:0048339) | 2.74321817 |
| 128 | chromosome segregation (GO:0007059) | 2.73842627 |
| 129 | DNA replication (GO:0006260) | 2.70510781 |
| 130 | spliceosomal complex assembly (GO:0000245) | 2.69521191 |
| 131 | RNA export from nucleus (GO:0006405) | 2.67424610 |
| 132 | regulation of histone H3-K9 methylation (GO:0051570) | 2.67351379 |
| 133 | sister chromatid segregation (GO:0000819) | 2.66910656 |
| 134 | mRNA export from nucleus (GO:0006406) | 2.66414626 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.80995917 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.14549980 |
| 3 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.07432730 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.76457249 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.48773810 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.47362883 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.04762542 |
| 8 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.95380761 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.84542742 |
| 10 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.66024207 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.60550039 |
| 12 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.56736398 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.55356147 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.54882799 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.54133810 |
| 16 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.53144433 |
| 17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.50583921 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.50256826 |
| 19 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.49262286 |
| 20 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.29067874 |
| 21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.26256391 |
| 22 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.23702959 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.21789371 |
| 24 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.18372577 |
| 25 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.16340946 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.08926532 |
| 27 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.07724434 |
| 28 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.07575805 |
| 29 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.04576988 |
| 30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.03868089 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.03075826 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.01370954 |
| 33 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.98397311 |
| 34 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.96500810 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.93897742 |
| 36 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.92281582 |
| 37 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.88167253 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.87178316 |
| 39 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.84098777 |
| 40 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.82817408 |
| 41 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.81969459 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81677254 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.74423035 |
| 44 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.72550106 |
| 45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.72279948 |
| 46 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.72110815 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70592416 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.68646279 |
| 49 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.64859354 |
| 50 | FUS_26573619_Chip-Seq_HEK293_Human | 1.63578188 |
| 51 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.60099687 |
| 52 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58377367 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.56386525 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.55707649 |
| 55 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54989356 |
| 56 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.41584909 |
| 57 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.36777661 |
| 58 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.34818454 |
| 59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33345358 |
| 60 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.31826566 |
| 61 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.31474222 |
| 62 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.30402746 |
| 63 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.29917164 |
| 64 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.29465117 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.28696905 |
| 66 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.27335484 |
| 67 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.26057124 |
| 68 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.25414352 |
| 69 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.20427153 |
| 70 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.18534713 |
| 71 | VDR_22108803_ChIP-Seq_LS180_Human | 1.16732584 |
| 72 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.15799744 |
| 73 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.15799744 |
| 74 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.15799744 |
| 75 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13538266 |
| 76 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.12879140 |
| 77 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.12572812 |
| 78 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.12008523 |
| 79 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.12007316 |
| 80 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08452032 |
| 81 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.06972378 |
| 82 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.05766354 |
| 83 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.05567955 |
| 84 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.05412987 |
| 85 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.05181666 |
| 86 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.02899214 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.02802829 |
| 88 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.02090497 |
| 89 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00445929 |
| 90 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00394233 |
| 91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99328228 |
| 92 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.98124402 |
| 93 | * ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.97916551 |
| 94 | P300_19829295_ChIP-Seq_ESCs_Human | 0.97005581 |
| 95 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96913248 |
| 96 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95010695 |
| 97 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.92260430 |
| 98 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91621294 |
| 99 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.91176707 |
| 100 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.90499164 |
| 101 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.88703711 |
| 102 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.87879458 |
| 103 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.87232641 |
| 104 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.87159038 |
| 105 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.86599796 |
| 106 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.86448443 |
| 107 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.86117431 |
| 108 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.85711567 |
| 109 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.85603441 |
| 110 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.85471328 |
| 111 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85183570 |
| 112 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.83687120 |
| 113 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.83552241 |
| 114 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.82891224 |
| 115 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.79696836 |
| 116 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.78616251 |
| 117 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.78086941 |
| 118 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.76006268 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.11152272 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.08286185 |
| 3 | MP0008057_abnormal_DNA_replication | 3.78094573 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.45079458 |
| 5 | MP0003077_abnormal_cell_cycle | 3.42485461 |
| 6 | MP0008058_abnormal_DNA_repair | 3.29729637 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 3.22183688 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.08297955 |
| 9 | MP0003123_paternal_imprinting | 2.88135681 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.47963706 |
| 11 | MP0006292_abnormal_olfactory_placode | 2.44018800 |
| 12 | MP0003941_abnormal_skin_development | 2.41796812 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.30048142 |
| 14 | MP0002254_reproductive_system_inflammat | 2.27846706 |
| 15 | MP0003121_genomic_imprinting | 2.25702807 |
| 16 | MP0000566_synostosis | 2.18934073 |
| 17 | MP0010030_abnormal_orbit_morphology | 2.13631209 |
| 18 | MP0003786_premature_aging | 1.92045714 |
| 19 | MP0001730_embryonic_growth_arrest | 1.89688976 |
| 20 | MP0003315_abnormal_perineum_morphology | 1.89289712 |
| 21 | MP0000350_abnormal_cell_proliferation | 1.84870778 |
| 22 | MP0003890_abnormal_embryonic-extraembry | 1.83866489 |
| 23 | MP0009053_abnormal_anal_canal | 1.82355225 |
| 24 | MP0000516_abnormal_urinary_system | 1.66869247 |
| 25 | MP0005367_renal/urinary_system_phenotyp | 1.66869247 |
| 26 | MP0001672_abnormal_embryogenesis/_devel | 1.64780971 |
| 27 | MP0005380_embryogenesis_phenotype | 1.64780971 |
| 28 | MP0003567_abnormal_fetal_cardiomyocyte | 1.64380503 |
| 29 | MP0001293_anophthalmia | 1.63921843 |
| 30 | MP0003136_yellow_coat_color | 1.58534677 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.50239317 |
| 32 | MP0003984_embryonic_growth_retardation | 1.50089214 |
| 33 | MP0002088_abnormal_embryonic_growth/wei | 1.47295446 |
| 34 | MP0002938_white_spotting | 1.46667377 |
| 35 | MP0001697_abnormal_embryo_size | 1.46643909 |
| 36 | MP0006072_abnormal_retinal_apoptosis | 1.44946858 |
| 37 | MP0002085_abnormal_embryonic_tissue | 1.44351312 |
| 38 | MP0002396_abnormal_hematopoietic_system | 1.35577880 |
| 39 | MP0003942_abnormal_urinary_system | 1.34492960 |
| 40 | MP0002163_abnormal_gland_morphology | 1.34084969 |
| 41 | MP0002160_abnormal_reproductive_system | 1.33326779 |
| 42 | MP0004197_abnormal_fetal_growth/weight/ | 1.32999417 |
| 43 | MP0004133_heterotaxia | 1.31991735 |
| 44 | MP0010352_gastrointestinal_tract_polyps | 1.31433537 |
| 45 | MP0002084_abnormal_developmental_patter | 1.30770992 |
| 46 | MP0003787_abnormal_imprinting | 1.28743585 |
| 47 | MP0003718_maternal_effect | 1.27534322 |
| 48 | MP0003119_abnormal_digestive_system | 1.26727349 |
| 49 | MP0003937_abnormal_limbs/digits/tail_de | 1.26628073 |
| 50 | MP0000049_abnormal_middle_ear | 1.23624084 |
| 51 | MP0000313_abnormal_cell_death | 1.20077391 |
| 52 | MP0009697_abnormal_copulation | 1.19868231 |
| 53 | MP0006035_abnormal_mitochondrial_morpho | 1.18995779 |
| 54 | MP0002080_prenatal_lethality | 1.16341363 |
| 55 | MP0001286_abnormal_eye_development | 1.16157742 |
| 56 | MP0002086_abnormal_extraembryonic_tissu | 1.15833147 |
| 57 | MP0005394_taste/olfaction_phenotype | 1.15273379 |
| 58 | MP0005499_abnormal_olfactory_system | 1.15273379 |
| 59 | MP0000490_abnormal_crypts_of | 1.14718680 |
| 60 | MP0002210_abnormal_sex_determination | 1.14224132 |
| 61 | MP0000579_abnormal_nail_morphology | 1.13774428 |
| 62 | MP0001529_abnormal_vocalization | 1.10981091 |
| 63 | MP0010307_abnormal_tumor_latency | 1.09008519 |
| 64 | MP0004808_abnormal_hematopoietic_stem | 1.07446146 |
| 65 | MP0002249_abnormal_larynx_morphology | 1.05892166 |
| 66 | MP0001119_abnormal_female_reproductive | 1.05416997 |
| 67 | MP0003943_abnormal_hepatobiliary_system | 1.03600144 |
| 68 | MP0002102_abnormal_ear_morphology | 1.02546581 |
| 69 | MP0005389_reproductive_system_phenotype | 1.02277557 |
| 70 | MP0003122_maternal_imprinting | 1.01103392 |
| 71 | MP0003861_abnormal_nervous_system | 1.00405259 |
| 72 | MP0000647_abnormal_sebaceous_gland | 0.99355825 |
| 73 | MP0003186_abnormal_redox_activity | 0.97721237 |
| 74 | MP0000537_abnormal_urethra_morphology | 0.97000004 |
| 75 | MP0005408_hypopigmentation | 0.95452927 |
| 76 | MP0002111_abnormal_tail_morphology | 0.93727988 |
| 77 | MP0001485_abnormal_pinna_reflex | 0.92863319 |
| 78 | MP0000428_abnormal_craniofacial_morphol | 0.91553746 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.89852752 |
| 80 | MP0001145_abnormal_male_reproductive | 0.89542688 |
| 81 | MP0002233_abnormal_nose_morphology | 0.89042192 |
| 82 | MP0008995_early_reproductive_senescence | 0.88259786 |
| 83 | MP0002132_abnormal_respiratory_system | 0.88237904 |
| 84 | MP0000015_abnormal_ear_pigmentation | 0.86276352 |
| 85 | MP0001346_abnormal_lacrimal_gland | 0.86208680 |
| 86 | MP0005391_vision/eye_phenotype | 0.86069291 |
| 87 | MP0001299_abnormal_eye_distance/ | 0.85982245 |
| 88 | MP0002019_abnormal_tumor_incidence | 0.85592375 |
| 89 | MP0003115_abnormal_respiratory_system | 0.85248961 |
| 90 | MP0000678_abnormal_parathyroid_gland | 0.84745693 |
| 91 | MP0009672_abnormal_birth_weight | 0.84683481 |
| 92 | MP0000631_abnormal_neuroendocrine_gland | 0.84641581 |
| 93 | MP0002751_abnormal_autonomic_nervous | 0.84355432 |
| 94 | MP0003385_abnormal_body_wall | 0.81492519 |
| 95 | MP0003938_abnormal_ear_development | 0.80967897 |
| 96 | MP0001188_hyperpigmentation | 0.79203401 |
| 97 | MP0002127_abnormal_cardiovascular_syste | 0.79116288 |
| 98 | MP0000653_abnormal_sex_gland | 0.79020296 |
| 99 | MP0004782_abnormal_surfactant_physiolog | 0.78670784 |
| 100 | MP0000534_abnormal_ureter_morphology | 0.77573066 |
| 101 | MP0005377_hearing/vestibular/ear_phenot | 0.77393495 |
| 102 | MP0003878_abnormal_ear_physiology | 0.77393495 |
| 103 | MP0003806_abnormal_nucleotide_metabolis | 0.76843457 |
| 104 | MP0000432_abnormal_head_morphology | 0.73999563 |
| 105 | MP0001919_abnormal_reproductive_system | 0.73289318 |
| 106 | MP0001177_atelectasis | 0.73150114 |
| 107 | MP0002009_preneoplasia | 0.72493464 |
| 108 | MP0003763_abnormal_thymus_physiology | 0.72406344 |
| 109 | MP0003755_abnormal_palate_morphology | 0.72197716 |
| 110 | MP0009703_decreased_birth_body | 0.71177007 |
| 111 | MP0003936_abnormal_reproductive_system | 0.70771375 |
| 112 | MP0002697_abnormal_eye_size | 0.70614958 |
| 113 | MP0002095_abnormal_skin_pigmentation | 0.70230830 |
| 114 | MP0005253_abnormal_eye_physiology | 0.69786934 |
| 115 | MP0005248_abnormal_Harderian_gland | 0.69475719 |
| 116 | MP0002092_abnormal_eye_morphology | 0.69023427 |
| 117 | MP0000358_abnormal_cell_content/ | 0.68381050 |
| 118 | MP0001929_abnormal_gametogenesis | 0.67960242 |
| 119 | MP0000383_abnormal_hair_follicle | 0.67828375 |
| 120 | MP0005075_abnormal_melanosome_morpholog | 0.67823473 |
| 121 | MP0003935_abnormal_craniofacial_develop | 0.67297084 |
| 122 | MP0004264_abnormal_extraembryonic_tissu | 0.67017418 |
| 123 | MP0002177_abnormal_outer_ear | 0.64736382 |
| 124 | MP0005395_other_phenotype | 0.63884567 |
| 125 | MP0010678_abnormal_skin_adnexa | 0.60050584 |
| 126 | MP0003698_abnormal_male_reproductive | 0.59918308 |
| 127 | MP0002081_perinatal_lethality | 0.59337556 |
| 128 | MP0002090_abnormal_vision | 0.57869156 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 3.92473299 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.85147482 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 3.79206122 |
| 4 | Abnormal lung lobation (HP:0002101) | 3.70363439 |
| 5 | Patellar aplasia (HP:0006443) | 3.25847148 |
| 6 | Septo-optic dysplasia (HP:0100842) | 3.20663302 |
| 7 | Ectopic kidney (HP:0000086) | 3.12757455 |
| 8 | Supernumerary spleens (HP:0009799) | 3.11557267 |
| 9 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.10644700 |
| 10 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.06023438 |
| 11 | Degeneration of anterior horn cells (HP:0002398) | 3.00787875 |
| 12 | Abnormality of the anterior horn cell (HP:0006802) | 3.00787875 |
| 13 | Colon cancer (HP:0003003) | 2.99021413 |
| 14 | Embryonal renal neoplasm (HP:0011794) | 2.98191370 |
| 15 | Medulloblastoma (HP:0002885) | 2.92542509 |
| 16 | Meckel diverticulum (HP:0002245) | 2.92266342 |
| 17 | 11 pairs of ribs (HP:0000878) | 2.90044822 |
| 18 | Multiple enchondromatosis (HP:0005701) | 2.80614258 |
| 19 | Breast hypoplasia (HP:0003187) | 2.77697665 |
| 20 | Abnormality of the ileum (HP:0001549) | 2.77433462 |
| 21 | Abnormality of chromosome stability (HP:0003220) | 2.68438216 |
| 22 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.68339640 |
| 23 | Optic nerve coloboma (HP:0000588) | 2.67734186 |
| 24 | Absent radius (HP:0003974) | 2.60504146 |
| 25 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.58685843 |
| 26 | Abnormality of the preputium (HP:0100587) | 2.54656337 |
| 27 | Carpal bone hypoplasia (HP:0001498) | 2.52609392 |
| 28 | Reticulocytopenia (HP:0001896) | 2.51019594 |
| 29 | Cortical dysplasia (HP:0002539) | 2.50250305 |
| 30 | Bilateral microphthalmos (HP:0007633) | 2.50016810 |
| 31 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.49972728 |
| 32 | Selective tooth agenesis (HP:0001592) | 2.49929703 |
| 33 | Impulsivity (HP:0100710) | 2.49240473 |
| 34 | Spastic diplegia (HP:0001264) | 2.48485674 |
| 35 | Rectal fistula (HP:0100590) | 2.44144342 |
| 36 | Rectovaginal fistula (HP:0000143) | 2.44144342 |
| 37 | Small intestinal stenosis (HP:0012848) | 2.43751646 |
| 38 | Duodenal stenosis (HP:0100867) | 2.43751646 |
| 39 | Aplasia involving forearm bones (HP:0009822) | 2.42714533 |
| 40 | Absent forearm bone (HP:0003953) | 2.42714533 |
| 41 | Agnosia (HP:0010524) | 2.40725269 |
| 42 | Facial cleft (HP:0002006) | 2.38214436 |
| 43 | Stenosis of the external auditory canal (HP:0000402) | 2.35384532 |
| 44 | Absent thumb (HP:0009777) | 2.33949904 |
| 45 | Ependymoma (HP:0002888) | 2.33097014 |
| 46 | Abnormality of the septum pellucidum (HP:0007375) | 2.32468622 |
| 47 | Absent septum pellucidum (HP:0001331) | 2.29893683 |
| 48 | Abnormality of the labia minora (HP:0012880) | 2.29137266 |
| 49 | Papillary thyroid carcinoma (HP:0002895) | 2.27561819 |
| 50 | Shawl scrotum (HP:0000049) | 2.27009152 |
| 51 | Intestinal atresia (HP:0011100) | 2.26881621 |
| 52 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.25816721 |
| 53 | Intestinal fistula (HP:0100819) | 2.24966478 |
| 54 | Abnormal number of incisors (HP:0011064) | 2.24566681 |
| 55 | Abnormality of the duodenum (HP:0002246) | 2.20360563 |
| 56 | Hyperglycinemia (HP:0002154) | 2.19897526 |
| 57 | Myelodysplasia (HP:0002863) | 2.19658646 |
| 58 | Abnormality of serum amino acid levels (HP:0003112) | 2.18480835 |
| 59 | Oral leukoplakia (HP:0002745) | 2.17969569 |
| 60 | Horseshoe kidney (HP:0000085) | 2.17024715 |
| 61 | Preaxial hand polydactyly (HP:0001177) | 2.16976264 |
| 62 | Diastasis recti (HP:0001540) | 2.16500622 |
| 63 | Cutaneous melanoma (HP:0012056) | 2.13234123 |
| 64 | Abnormality of methionine metabolism (HP:0010901) | 2.11958826 |
| 65 | Deep philtrum (HP:0002002) | 2.11633334 |
| 66 | Glioma (HP:0009733) | 2.11467551 |
| 67 | Hepatoblastoma (HP:0002884) | 2.10015628 |
| 68 | Abnormality of the renal collecting system (HP:0004742) | 2.09617027 |
| 69 | Deviation of the thumb (HP:0009603) | 2.09339693 |
| 70 | Triphalangeal thumb (HP:0001199) | 2.09293667 |
| 71 | Rhabdomyosarcoma (HP:0002859) | 2.08916191 |
| 72 | True hermaphroditism (HP:0010459) | 2.07101782 |
| 73 | Abnormal pancreas size (HP:0012094) | 2.06586227 |
| 74 | Missing ribs (HP:0000921) | 2.05580866 |
| 75 | Increased hepatocellular lipid droplets (HP:0006565) | 2.04613959 |
| 76 | Spinal cord lesions (HP:0100561) | 2.02862464 |
| 77 | Syringomyelia (HP:0003396) | 2.02862464 |
| 78 | Sloping forehead (HP:0000340) | 2.02670154 |
| 79 | Neoplasm of the adrenal cortex (HP:0100641) | 2.02247116 |
| 80 | Renal hypoplasia (HP:0000089) | 2.01520126 |
| 81 | Neoplasm of the adrenal gland (HP:0100631) | 2.00056059 |
| 82 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.99456334 |
| 83 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.98938884 |
| 84 | Short 4th metacarpal (HP:0010044) | 1.98938884 |
| 85 | Increased nuchal translucency (HP:0010880) | 1.98300862 |
| 86 | Biliary tract neoplasm (HP:0100574) | 1.98002809 |
| 87 | Duplicated collecting system (HP:0000081) | 1.95653951 |
| 88 | Maternal diabetes (HP:0009800) | 1.93915352 |
| 89 | Cleft eyelid (HP:0000625) | 1.93421252 |
| 90 | Atresia of the external auditory canal (HP:0000413) | 1.93185312 |
| 91 | Proximal placement of thumb (HP:0009623) | 1.92309152 |
| 92 | Bone marrow hypocellularity (HP:0005528) | 1.91418316 |
| 93 | Aplastic anemia (HP:0001915) | 1.90984867 |
| 94 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.90491159 |
| 95 | Anophthalmia (HP:0000528) | 1.89613519 |
| 96 | Vaginal fistula (HP:0004320) | 1.88894286 |
| 97 | Hypoglycemic seizures (HP:0002173) | 1.88523825 |
| 98 | Hyperglycinuria (HP:0003108) | 1.88475379 |
| 99 | Abnormality of glycine metabolism (HP:0010895) | 1.87940419 |
| 100 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.87940419 |
| 101 | Gastrointestinal atresia (HP:0002589) | 1.87270000 |
| 102 | Bifid tongue (HP:0010297) | 1.86589717 |
| 103 | Breast aplasia (HP:0100783) | 1.85029735 |
| 104 | Hypoplastic female external genitalia (HP:0012815) | 1.84436196 |
| 105 | Abnormality of the pons (HP:0007361) | 1.83550886 |
| 106 | Neoplasm of striated muscle (HP:0009728) | 1.82905412 |
| 107 | Abnormal hair whorl (HP:0010721) | 1.82797337 |
| 108 | Chronic bronchitis (HP:0004469) | 1.81834655 |
| 109 | Short thumb (HP:0009778) | 1.81603451 |
| 110 | Embryonal neoplasm (HP:0002898) | 1.80584935 |
| 111 | Premature graying of hair (HP:0002216) | 1.80090222 |
| 112 | Volvulus (HP:0002580) | 1.80019353 |
| 113 | Asymmetry of the thorax (HP:0001555) | 1.79825852 |
| 114 | Abnormal biliary tract morphology (HP:0012440) | 1.79329721 |
| 115 | Type I transferrin isoform profile (HP:0003642) | 1.79017434 |
| 116 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.78353859 |
| 117 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.78237098 |
| 118 | Cellular immunodeficiency (HP:0005374) | 1.77851916 |
| 119 | Abnormality of homocysteine metabolism (HP:0010919) | 1.77828098 |
| 120 | Homocystinuria (HP:0002156) | 1.77828098 |
| 121 | Optic nerve hypoplasia (HP:0000609) | 1.77392085 |
| 122 | Aqueductal stenosis (HP:0002410) | 1.77384979 |
| 123 | Breast carcinoma (HP:0003002) | 1.77358434 |
| 124 | Anal stenosis (HP:0002025) | 1.77266703 |
| 125 | Dandy-Walker malformation (HP:0001305) | 1.76986093 |
| 126 | High anterior hairline (HP:0009890) | 1.76724200 |
| 127 | Thyroid carcinoma (HP:0002890) | 1.76532550 |
| 128 | Amaurosis fugax (HP:0100576) | 1.76298056 |
| 129 | Esophageal atresia (HP:0002032) | 1.75661346 |
| 130 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.75502223 |
| 131 | Neoplasm of the pancreas (HP:0002894) | 1.75488792 |
| 132 | Pancreatic fibrosis (HP:0100732) | 1.75011510 |
| 133 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.74921707 |
| 134 | Lipid accumulation in hepatocytes (HP:0006561) | 1.74621909 |
| 135 | Abnormality of the incisor (HP:0000676) | 1.73965409 |
| 136 | Abnormality of the metopic suture (HP:0005556) | 1.72526680 |
| 137 | Choanal stenosis (HP:0000452) | 1.72446776 |
| 138 | Methylmalonic acidemia (HP:0002912) | 1.72083016 |
| 139 | Tracheoesophageal fistula (HP:0002575) | 1.72056603 |
| 140 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.71787154 |
| 141 | Gastrointestinal carcinoma (HP:0002672) | 1.71787154 |
| 142 | Labial hypoplasia (HP:0000066) | 1.71598270 |
| 143 | Hypoplasia of the pons (HP:0012110) | 1.71241742 |
| 144 | Pancreatic cysts (HP:0001737) | 1.70901203 |
| 145 | Ovarian neoplasm (HP:0100615) | 1.70583291 |
| 146 | Uterine neoplasm (HP:0010784) | 1.70211275 |
| 147 | Asplenia (HP:0001746) | 1.68923764 |
| 148 | Absent eyebrow (HP:0002223) | 1.68863466 |
| 149 | Neoplasm of the colon (HP:0100273) | 1.68808341 |
| 150 | Clubbing of toes (HP:0100760) | 1.68548367 |
| 151 | Abnormality of the carotid arteries (HP:0005344) | 1.68488132 |
| 152 | Abnormality of the astrocytes (HP:0100707) | 1.67126187 |
| 153 | Astrocytoma (HP:0009592) | 1.67126187 |
| 154 | Microvesicular hepatic steatosis (HP:0001414) | 1.67100001 |
| 155 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.67034805 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SRPK1 | 3.74335349 |
| 2 | CDC7 | 3.40022295 |
| 3 | WEE1 | 3.22700009 |
| 4 | BUB1 | 3.08401312 |
| 5 | EIF2AK1 | 2.92366273 |
| 6 | MKNK1 | 2.83400287 |
| 7 | PLK4 | 2.80090664 |
| 8 | VRK2 | 2.72742196 |
| 9 | ZAK | 2.59247509 |
| 10 | BRSK2 | 2.53472471 |
| 11 | TAF1 | 2.29019357 |
| 12 | PLK3 | 2.24957606 |
| 13 | TRIM28 | 2.18261794 |
| 14 | STK38L | 2.14280553 |
| 15 | ACVR1B | 2.12542431 |
| 16 | MKNK2 | 2.11234230 |
| 17 | WNK3 | 2.10266835 |
| 18 | TTK | 2.08057984 |
| 19 | PASK | 2.01660758 |
| 20 | TNIK | 2.01516897 |
| 21 | TSSK6 | 2.00327688 |
| 22 | PLK1 | 1.86003261 |
| 23 | EIF2AK3 | 1.82953596 |
| 24 | NEK1 | 1.75751740 |
| 25 | ATR | 1.73290688 |
| 26 | VRK1 | 1.70444866 |
| 27 | STK24 | 1.68024548 |
| 28 | BRSK1 | 1.52838570 |
| 29 | CDK7 | 1.52505982 |
| 30 | CDK19 | 1.52296051 |
| 31 | RPS6KB2 | 1.52089453 |
| 32 | NEK2 | 1.51221560 |
| 33 | ERBB3 | 1.49074877 |
| 34 | AURKB | 1.47876114 |
| 35 | OBSCN | 1.46902947 |
| 36 | EIF2AK2 | 1.43935695 |
| 37 | CHEK2 | 1.38363166 |
| 38 | AKT3 | 1.37700261 |
| 39 | MAP3K10 | 1.36266090 |
| 40 | STK4 | 1.34229713 |
| 41 | STK16 | 1.32025947 |
| 42 | TGFBR1 | 1.30652989 |
| 43 | TLK1 | 1.29196122 |
| 44 | BCR | 1.25438251 |
| 45 | BMPR1B | 1.18377613 |
| 46 | CDK12 | 1.16603720 |
| 47 | CLK1 | 1.16555312 |
| 48 | EPHA2 | 1.11204030 |
| 49 | MAPKAPK3 | 1.11188349 |
| 50 | CHEK1 | 1.10497490 |
| 51 | MAP3K14 | 1.08180974 |
| 52 | BMPR2 | 1.05272534 |
| 53 | EEF2K | 1.04633131 |
| 54 | BRAF | 1.04577219 |
| 55 | AURKA | 1.04341783 |
| 56 | NME1 | 1.04282642 |
| 57 | FGFR2 | 1.03498509 |
| 58 | ALK | 1.00805097 |
| 59 | BRD4 | 1.00058703 |
| 60 | ATM | 0.99253603 |
| 61 | NLK | 0.97569516 |
| 62 | FGFR1 | 0.96832880 |
| 63 | PIM1 | 0.94651410 |
| 64 | OXSR1 | 0.92824712 |
| 65 | SIK3 | 0.90761733 |
| 66 | TRPM7 | 0.89672386 |
| 67 | YES1 | 0.88727548 |
| 68 | MELK | 0.87581916 |
| 69 | STK3 | 0.83959498 |
| 70 | CDK4 | 0.83130009 |
| 71 | NUAK1 | 0.82882447 |
| 72 | MST4 | 0.82871017 |
| 73 | CSNK1G1 | 0.82745041 |
| 74 | LATS1 | 0.82553899 |
| 75 | MAP3K8 | 0.81810490 |
| 76 | RPS6KA4 | 0.81173505 |
| 77 | NEK6 | 0.79991648 |
| 78 | CCNB1 | 0.78850032 |
| 79 | DYRK3 | 0.78168431 |
| 80 | CDK2 | 0.77064598 |
| 81 | CHUK | 0.75750170 |
| 82 | PBK | 0.75721918 |
| 83 | FLT3 | 0.71694111 |
| 84 | ERBB4 | 0.70390534 |
| 85 | CSNK2A1 | 0.69817027 |
| 86 | CDK8 | 0.67848220 |
| 87 | MAP3K4 | 0.65881346 |
| 88 | TESK1 | 0.64970959 |
| 89 | STK10 | 0.64747023 |
| 90 | RPS6KB1 | 0.63682384 |
| 91 | CDK1 | 0.63132391 |
| 92 | MAPK13 | 0.61205309 |
| 93 | TAOK2 | 0.60244045 |
| 94 | CSNK2A2 | 0.57478969 |
| 95 | MAP4K2 | 0.55731380 |
| 96 | SGK2 | 0.55637518 |
| 97 | MAP2K6 | 0.54196773 |
| 98 | MAP2K3 | 0.53788859 |
| 99 | PAK4 | 0.51545108 |
| 100 | CSNK1E | 0.51346349 |
| 101 | CASK | 0.50214353 |
| 102 | INSRR | 0.49804816 |
| 103 | GRK1 | 0.49695454 |
| 104 | PLK2 | 0.47220495 |
| 105 | RPS6KA5 | 0.46996748 |
| 106 | CSNK1G3 | 0.46260462 |
| 107 | SMG1 | 0.46026419 |
| 108 | DYRK2 | 0.45168781 |
| 109 | MAP3K3 | 0.44639935 |
| 110 | MYLK | 0.42837143 |
| 111 | CSNK1G2 | 0.42777195 |
| 112 | PRKCI | 0.42684929 |
| 113 | PIM2 | 0.42332505 |
| 114 | CDK3 | 0.41585086 |
| 115 | NEK9 | 0.38111845 |
| 116 | IKBKB | 0.37981083 |
| 117 | CDK6 | 0.37833957 |
| 118 | RPS6KC1 | 0.36987295 |
| 119 | RPS6KL1 | 0.36987295 |
| 120 | TIE1 | 0.36723098 |
| 121 | IRAK4 | 0.36631288 |
| 122 | PAK1 | 0.36183724 |
| 123 | RPS6KA6 | 0.34928760 |
| 124 | CSNK1A1L | 0.34540845 |
| 125 | MAPKAPK2 | 0.33781143 |
| 126 | PRKDC | 0.33545690 |
| 127 | STK39 | 0.33150556 |
| 128 | MARK3 | 0.33137376 |
| 129 | LIMK1 | 0.32806747 |
| 130 | PNCK | 0.32612167 |
| 131 | DAPK1 | 0.23891859 |
| 132 | PDK2 | 0.23703493 |
| 133 | EGFR | 0.23648255 |
| 134 | DYRK1A | 0.20725069 |
| 135 | LATS2 | 0.19377106 |
| 136 | CSNK1A1 | 0.18918347 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.53493728 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.39551199 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.60378650 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.31814296 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.21555246 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.19376291 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 3.04713415 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 3.00018461 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.97148770 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.84547012 |
| 11 | Cell cycle_Homo sapiens_hsa04110 | 2.81941224 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.74999169 |
| 13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.59595716 |
| 14 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.43592905 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 2.34599410 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.32776134 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 2.28555919 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.27120317 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 2.26623625 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.99390994 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.66150042 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.58264095 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.54186044 |
| 24 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.44387239 |
| 25 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.42739744 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.40537685 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.38178076 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28688667 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.28559686 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.26702736 |
| 31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.23241595 |
| 32 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.20784788 |
| 33 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.19066057 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.17620760 |
| 35 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.16587491 |
| 36 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.13763196 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13425883 |
| 38 | Thyroid cancer_Homo sapiens_hsa05216 | 1.10106195 |
| 39 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.09810877 |
| 40 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.05789259 |
| 41 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.03019568 |
| 42 | Carbon metabolism_Homo sapiens_hsa01200 | 0.99721346 |
| 43 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.92242921 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.90787245 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.85714622 |
| 46 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.83879547 |
| 47 | HTLV-I infection_Homo sapiens_hsa05166 | 0.80998211 |
| 48 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.79836578 |
| 49 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.78674271 |
| 50 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.78383421 |
| 51 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.77783048 |
| 52 | Protein export_Homo sapiens_hsa03060 | 0.77030243 |
| 53 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.72797074 |
| 54 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.72611754 |
| 55 | Allograft rejection_Homo sapiens_hsa05330 | 0.71841564 |
| 56 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.69926550 |
| 57 | Huntingtons disease_Homo sapiens_hsa05016 | 0.69764006 |
| 58 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.69119459 |
| 59 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.66379471 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65453110 |
| 61 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.63041523 |
| 62 | Lysine degradation_Homo sapiens_hsa00310 | 0.62520993 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.59781552 |
| 64 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.59573486 |
| 65 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.58022926 |
| 66 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.55631021 |
| 67 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.54930001 |
| 68 | Adherens junction_Homo sapiens_hsa04520 | 0.54741963 |
| 69 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53172558 |
| 70 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.52212833 |
| 71 | Measles_Homo sapiens_hsa05162 | 0.52196152 |
| 72 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50009981 |
| 73 | Influenza A_Homo sapiens_hsa05164 | 0.49352883 |
| 74 | Alzheimers disease_Homo sapiens_hsa05010 | 0.49208330 |
| 75 | Legionellosis_Homo sapiens_hsa05134 | 0.46887268 |
| 76 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.46829323 |
| 77 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.44230684 |
| 78 | Apoptosis_Homo sapiens_hsa04210 | 0.44220015 |
| 79 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.44039723 |
| 80 | Viral myocarditis_Homo sapiens_hsa05416 | 0.43596145 |
| 81 | Alcoholism_Homo sapiens_hsa05034 | 0.42614285 |
| 82 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.42559124 |
| 83 | Pathways in cancer_Homo sapiens_hsa05200 | 0.42109596 |
| 84 | Parkinsons disease_Homo sapiens_hsa05012 | 0.41705241 |
| 85 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41073758 |
| 86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40115209 |
| 87 | Phototransduction_Homo sapiens_hsa04744 | 0.39811633 |
| 88 | Tight junction_Homo sapiens_hsa04530 | 0.39546267 |
| 89 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.38620041 |
| 90 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.37646527 |
| 91 | Colorectal cancer_Homo sapiens_hsa05210 | 0.37250048 |
| 92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36921559 |
| 93 | Galactose metabolism_Homo sapiens_hsa00052 | 0.35670899 |
| 94 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.35268520 |
| 95 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.35167549 |
| 96 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34781863 |
| 97 | Prostate cancer_Homo sapiens_hsa05215 | 0.33958933 |
| 98 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.32881723 |
| 99 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.32645196 |
| 100 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.31689237 |
| 101 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.30259028 |
| 102 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.30058866 |
| 103 | Endometrial cancer_Homo sapiens_hsa05213 | 0.29751273 |
| 104 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.29426794 |
| 105 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.29200595 |
| 106 | Hepatitis B_Homo sapiens_hsa05161 | 0.28269669 |
| 107 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.28091516 |
| 108 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.27858299 |
| 109 | Peroxisome_Homo sapiens_hsa04146 | 0.27267391 |
| 110 | Retinol metabolism_Homo sapiens_hsa00830 | 0.27185344 |
| 111 | Melanoma_Homo sapiens_hsa05218 | 0.26990976 |
| 112 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.25912224 |
| 113 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.25834053 |
| 114 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25782174 |
| 115 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.24670810 |
| 116 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.24382968 |
| 117 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24346517 |
| 118 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.23951660 |
| 119 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.23765234 |
| 120 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.23629832 |
| 121 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.23592072 |
| 122 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.23207072 |
| 123 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23146709 |
| 124 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.23117648 |
| 125 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.22665734 |
| 126 | Shigellosis_Homo sapiens_hsa05131 | 0.21873840 |
| 127 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.20541634 |
| 128 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.19998316 |
| 129 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.19345042 |
| 130 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.19009567 |
| 131 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.18736749 |
| 132 | Asthma_Homo sapiens_hsa05310 | 0.18392871 |
| 133 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.18210178 |
| 134 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.17431953 |
| 135 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.17170672 |
| 136 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.15753074 |
| 137 | Bladder cancer_Homo sapiens_hsa05219 | 0.13015209 |
| 138 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.13008276 |
| 139 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.12713108 |
| 140 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.12279707 |
| 141 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.11615206 |
| 142 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.11283500 |
| 143 | Metabolic pathways_Homo sapiens_hsa01100 | 0.10746588 |

