ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	4.81051684
2	DNA deamination (GO:0045006)	4.77983005
3	DNA double-strand break processing (GO:0000729)	4.33781055
4	DNA damage response, detection of DNA damage (GO:0042769)	4.04435729
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.65250240
6	regulation of chronic inflammatory response (GO:0002676)	3.60697981
7	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.56364669
8	termination of RNA polymerase III transcription (GO:0006386)	3.56364669
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.55639215
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.55639215
11	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.54954399
12	regulation of mitotic spindle checkpoint (GO:1903504)	3.54954399
13	DNA catabolic process, exonucleolytic (GO:0000738)	3.51124798
14	mitochondrial RNA metabolic process (GO:0000959)	3.44444497
15	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39145363
16	cytidine deamination (GO:0009972)	3.38364336
17	cytidine metabolic process (GO:0046087)	3.38364336
18	cytidine catabolic process (GO:0006216)	3.38364336
19	protein complex biogenesis (GO:0070271)	3.38005497
20	pseudouridine synthesis (GO:0001522)	3.35807145
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.34597419
22	ATP synthesis coupled proton transport (GO:0015986)	3.34597419
23	DNA replication checkpoint (GO:0000076)	3.32254792
24	chaperone-mediated protein transport (GO:0072321)	3.31143377
25	protein neddylation (GO:0045116)	3.26395508
26	cullin deneddylation (GO:0010388)	3.25894377
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25740386
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25740386
29	NADH dehydrogenase complex assembly (GO:0010257)	3.25740386
30	maturation of 5.8S rRNA (GO:0000460)	3.25702320
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.22773189
32	respiratory chain complex IV assembly (GO:0008535)	3.22192943
33	peptidyl-histidine modification (GO:0018202)	3.18856002
34	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.15653869
35	DNA methylation involved in gamete generation (GO:0043046)	3.10262592
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09478526
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.08924155
38	L-fucose catabolic process (GO:0042355)	3.07676671
39	fucose catabolic process (GO:0019317)	3.07676671
40	L-fucose metabolic process (GO:0042354)	3.07676671
41	protein deneddylation (GO:0000338)	3.03480592
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03454640
43	protein-cofactor linkage (GO:0018065)	3.02164028
44	somatic diversification of immunoglobulins (GO:0016445)	3.02139939
45	DNA ligation (GO:0006266)	3.00814368
46	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.99829093
47	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.99829093
48	isotype switching (GO:0045190)	2.99829093
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98135883
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98135883
51	piRNA metabolic process (GO:0034587)	2.94202780
52	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.93922613
53	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.92631427
54	rRNA modification (GO:0000154)	2.92229225
55	behavioral response to nicotine (GO:0035095)	2.91955977
56	spliceosomal snRNP assembly (GO:0000387)	2.88065548
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.87254083
58	response to pheromone (GO:0019236)	2.86659757
59	tRNA processing (GO:0008033)	2.86528156
60	cytochrome complex assembly (GO:0017004)	2.85155378
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84695196
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84570379
63	organelle disassembly (GO:1903008)	2.83744223
64	prenylation (GO:0097354)	2.82676183
65	protein prenylation (GO:0018342)	2.82676183
66	chromatin remodeling at centromere (GO:0031055)	2.81426992
67	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.79048124
68	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.79048124
69	regulation of translation, ncRNA-mediated (GO:0045974)	2.79048124
70	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78981006
71	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76300631
72	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.75807369
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.75807369
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.75807369
75	kinetochore assembly (GO:0051382)	2.73823507
76	double-strand break repair via homologous recombination (GO:0000724)	2.71459351
77	regulation of meiosis I (GO:0060631)	2.71421810
78	recombinational repair (GO:0000725)	2.71081030
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.70163363
80	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.68901065
81	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.68901065
82	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67820651
83	tRNA modification (GO:0006400)	2.67278086
84	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.67129893
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.66959516
86	negative regulation of ligase activity (GO:0051352)	2.66797195
87	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66797195
88	tRNA metabolic process (GO:0006399)	2.66526127
89	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.66038842
90	histone mRNA metabolic process (GO:0008334)	2.65487311
91	termination of RNA polymerase I transcription (GO:0006363)	2.65194131
92	protein K6-linked ubiquitination (GO:0085020)	2.64014533
93	somatic diversification of immune receptors (GO:0002200)	2.63532276
94	protein polyglutamylation (GO:0018095)	2.62275922
95	synapsis (GO:0007129)	2.61636440
96	centriole replication (GO:0007099)	2.61529544
97	CENP-A containing nucleosome assembly (GO:0034080)	2.61457771
98	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.61019956
99	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.61019956
100	cell wall macromolecule catabolic process (GO:0016998)	2.60656199

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.70018021
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.84613312
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84514714
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.05919205
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03754691
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82755733
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.76440363
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.76028797
9	VDR_22108803_ChIP-Seq_LS180_Human	2.68578815
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.65116302
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.58341406
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.45050038
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41594766
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33906406
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31793670
16	EWS_26573619_Chip-Seq_HEK293_Human	2.31365183
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.22343810
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.22020389
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14042084
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.07977240
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06303446
22	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03765313
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01529255
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00954679
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.94021482
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93168451
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88290790
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84944776
29	FUS_26573619_Chip-Seq_HEK293_Human	1.83443824
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.82980261
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73643786
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72166528
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.59642001
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55689397
35	P300_19829295_ChIP-Seq_ESCs_Human	1.55143478
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51285372
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.50457529
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46754428
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45698523
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45526763
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42222691
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35917867
43	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.34339799
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.31782653
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31553737
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31333054
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.31177712
48	E2F7_22180533_ChIP-Seq_HELA_Human	1.29843911
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29788158
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23757643
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23052409
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22244738
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22163780
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22115975
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.18112037
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17859143
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17543250
58	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.15759401
59	GATA1_22025678_ChIP-Seq_K562_Human	1.13354677
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13051105
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13051105
62	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12761418
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.10355563
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09332242
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.09249483
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09249483
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08587027
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07088482
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06221372
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04662645
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04662645
72	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04572087
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99981312
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99247367
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97797339
76	TTF2_22483619_ChIP-Seq_HELA_Human	0.97450011
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96904380
78	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96800738
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96581816
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96274307
81	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.96195576
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96007772
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95703043
84	P300_18555785_Chip-Seq_ESCs_Mouse	0.94771515
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.94522678
86	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94441021
87	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.93370653
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93032118
89	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.92939171
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.91404013
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91089282
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.89984332
93	ER_23166858_ChIP-Seq_MCF-7_Human	0.89912146
94	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.89302274
95	AR_20517297_ChIP-Seq_VCAP_Human	0.87622600
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.87542371
97	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.87160594
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.85895279
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.85559565
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.85317120

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.45971415
2	MP0008058_abnormal_DNA_repair	3.18694413
3	MP0001986_abnormal_taste_sensitivity	2.93582021
4	MP0005645_abnormal_hypothalamus_physiol	2.84337593
5	MP0002102_abnormal_ear_morphology	2.73251332
6	MP0008872_abnormal_physiological_respon	2.64161235
7	MP0003718_maternal_effect	2.53161402
8	MP0008875_abnormal_xenobiotic_pharmacok	2.45656752
9	MP0006292_abnormal_olfactory_placode	2.40841629
10	MP0003011_delayed_dark_adaptation	2.37016175
11	MP0006072_abnormal_retinal_apoptosis	2.29880984
12	MP0003195_calcinosis	2.18626523
13	MP0010094_abnormal_chromosome_stability	2.02863338
14	MP0005671_abnormal_response_to	2.01017354
15	MP0003786_premature_aging	1.99903972
16	MP0008057_abnormal_DNA_replication	1.94234725
17	MP0009697_abnormal_copulation	1.92164752
18	MP0005253_abnormal_eye_physiology	1.91801659
19	MP0004957_abnormal_blastocyst_morpholog	1.91093397
20	MP0003567_abnormal_fetal_cardiomyocyte	1.81167470
21	MP0008995_early_reproductive_senescence	1.78794347
22	MP0005084_abnormal_gallbladder_morpholo	1.72820514
23	MP0000372_irregular_coat_pigmentation	1.71258217
24	MP0005551_abnormal_eye_electrophysiolog	1.69009266
25	MP0004142_abnormal_muscle_tone	1.65394067
26	MP0002736_abnormal_nociception_after	1.62683335
27	MP0001984_abnormal_olfaction	1.58601407
28	MP0001968_abnormal_touch/_nociception	1.55850980
29	MP0001529_abnormal_vocalization	1.50661127
30	MP0001485_abnormal_pinna_reflex	1.48389682
31	MP0003186_abnormal_redox_activity	1.43469235
32	MP0002938_white_spotting	1.35147208
33	MP0006036_abnormal_mitochondrial_physio	1.34979417
34	MP0001293_anophthalmia	1.33691969
35	MP0009745_abnormal_behavioral_response	1.29716697
36	MP0003693_abnormal_embryo_hatching	1.29652358
37	MP0001348_abnormal_lacrimal_gland	1.29486377
38	MP0003646_muscle_fatigue	1.28723812
39	MP0009046_muscle_twitch	1.28626926
40	MP0004133_heterotaxia	1.26509394
41	MP0003121_genomic_imprinting	1.22792263
42	MP0004043_abnormal_pH_regulation	1.22311354
43	MP0001929_abnormal_gametogenesis	1.21774760
44	MP0000631_abnormal_neuroendocrine_gland	1.21199525
45	MP0002210_abnormal_sex_determination	1.20566201
46	MP0005310_abnormal_salivary_gland	1.20169496
47	MP0003890_abnormal_embryonic-extraembry	1.19379891
48	MP0003119_abnormal_digestive_system	1.16277313
49	MP0005646_abnormal_pituitary_gland	1.13837688
50	MP0009333_abnormal_splenocyte_physiolog	1.11116109
51	MP0006035_abnormal_mitochondrial_morpho	1.06833273
52	MP0008789_abnormal_olfactory_epithelium	1.05824629
53	MP0000653_abnormal_sex_gland	1.05602749
54	MP0004885_abnormal_endolymph	1.05417115
55	MP0001119_abnormal_female_reproductive	1.05129570
56	MP0001501_abnormal_sleep_pattern	1.04986130
57	MP0004145_abnormal_muscle_electrophysio	1.04611557
58	MP0002272_abnormal_nervous_system	1.02848262
59	MP0001188_hyperpigmentation	1.01829025
60	MP0005389_reproductive_system_phenotype	1.01785477
61	MP0003943_abnormal_hepatobiliary_system	0.99640950
62	MP0004742_abnormal_vestibular_system	0.98810444
63	MP0005410_abnormal_fertilization	0.98465651
64	MP0001145_abnormal_male_reproductive	0.98418146
65	MP0003698_abnormal_male_reproductive	0.95143399
66	MP0002163_abnormal_gland_morphology	0.94456719
67	MP0005377_hearing/vestibular/ear_phenot	0.94027790
68	MP0003878_abnormal_ear_physiology	0.94027790
69	MP0005395_other_phenotype	0.93897355
70	MP0003787_abnormal_imprinting	0.93822818
71	MP0005391_vision/eye_phenotype	0.93681400
72	MP0003283_abnormal_digestive_organ	0.92331122
73	MP0002751_abnormal_autonomic_nervous	0.91785524
74	MP0002277_abnormal_respiratory_mucosa	0.90974166
75	MP0003077_abnormal_cell_cycle	0.90510725
76	MP0008932_abnormal_embryonic_tissue	0.88787955
77	MP0001919_abnormal_reproductive_system	0.88300070
78	MP0002638_abnormal_pupillary_reflex	0.87322061
79	MP0003880_abnormal_central_pattern	0.86928298
80	MP0001764_abnormal_homeostasis	0.84654073
81	MP0003122_maternal_imprinting	0.83477855
82	MP0002928_abnormal_bile_duct	0.81169043
83	MP0004215_abnormal_myocardial_fiber	0.78079369
84	MP0003136_yellow_coat_color	0.73486926
85	MP0005195_abnormal_posterior_eye	0.72113665
86	MP0002160_abnormal_reproductive_system	0.71607487
87	MP0001286_abnormal_eye_development	0.70223149
88	MP0003111_abnormal_nucleus_morphology	0.69768656
89	MP0001486_abnormal_startle_reflex	0.69715235
90	MP0000647_abnormal_sebaceous_gland	0.69438752
91	MP0010386_abnormal_urinary_bladder	0.64140989
92	MP0003137_abnormal_impulse_conducting	0.63946763
93	MP0009785_altered_susceptibility_to	0.63297858
94	MP0003763_abnormal_thymus_physiology	0.63136825
95	MP0008873_increased_physiological_sensi	0.62951671
96	MP0001697_abnormal_embryo_size	0.61629520
97	MP0002876_abnormal_thyroid_physiology	0.61324252
98	MP0001873_stomach_inflammation	0.60993126
99	MP0001502_abnormal_circadian_rhythm	0.60748035
100	MP0000516_abnormal_urinary_system	0.60499096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the pons (HP:0007361)	3.28872856
2	Abnormality of midbrain morphology (HP:0002418)	3.27045138
3	Molar tooth sign on MRI (HP:0002419)	3.27045138
4	Nephronophthisis (HP:0000090)	3.18887224
5	Acute necrotizing encephalopathy (HP:0006965)	3.16150921
6	3-Methylglutaconic aciduria (HP:0003535)	3.13899602
7	Abnormality of the labia minora (HP:0012880)	3.10508151
8	True hermaphroditism (HP:0010459)	3.04342026
9	Pancreatic cysts (HP:0001737)	3.02410520
10	Pendular nystagmus (HP:0012043)	2.93410404
11	Progressive macrocephaly (HP:0004481)	2.86858661
12	Acute encephalopathy (HP:0006846)	2.84295944
13	Duplicated collecting system (HP:0000081)	2.80674436
14	Chronic hepatic failure (HP:0100626)	2.78300673
15	Mitochondrial inheritance (HP:0001427)	2.76155947
16	Increased CSF lactate (HP:0002490)	2.74581706
17	Increased hepatocellular lipid droplets (HP:0006565)	2.72405131
18	Aplasia/hypoplasia of the uterus (HP:0008684)	2.70718471
19	Abnormality of the renal medulla (HP:0100957)	2.70652028
20	Large for gestational age (HP:0001520)	2.70209248
21	Congenital stationary night blindness (HP:0007642)	2.62885807
22	Gonadal dysgenesis (HP:0000133)	2.62692831
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.59477257
24	Abnormality of the renal collecting system (HP:0004742)	2.54674764
25	Meckel diverticulum (HP:0002245)	2.53046842
26	Progressive inability to walk (HP:0002505)	2.52244016
27	Lipid accumulation in hepatocytes (HP:0006561)	2.48540147
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46186635
29	Abnormality of the ileum (HP:0001549)	2.44604882
30	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42409542
31	Chromsome breakage (HP:0040012)	2.41448249
32	Hypoplasia of the pons (HP:0012110)	2.33844168
33	Increased serum lactate (HP:0002151)	2.33429403
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29796354
35	Absent/shortened dynein arms (HP:0200106)	2.29796354
36	Exertional dyspnea (HP:0002875)	2.28404042
37	Pancreatic fibrosis (HP:0100732)	2.28232145
38	Severe combined immunodeficiency (HP:0004430)	2.26270706
39	Thyroiditis (HP:0100646)	2.25510099
40	Aplastic anemia (HP:0001915)	2.25021166
41	Abnormality of alanine metabolism (HP:0010916)	2.23831600
42	Hyperalaninemia (HP:0003348)	2.23831600
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23831600
44	Methylmalonic acidemia (HP:0002912)	2.22644005
45	Abnormality of the preputium (HP:0100587)	2.22219634
46	Hypoplasia of the uterus (HP:0000013)	2.22200637
47	Gaze-evoked nystagmus (HP:0000640)	2.21038654
48	Hepatocellular necrosis (HP:0001404)	2.19082697
49	Chorioretinal atrophy (HP:0000533)	2.18949992
50	Congenital, generalized hypertrichosis (HP:0004540)	2.16418399
51	Bilateral microphthalmos (HP:0007633)	2.13673816
52	Medial flaring of the eyebrow (HP:0010747)	2.13220857
53	Bile duct proliferation (HP:0001408)	2.08922810
54	Abnormal biliary tract physiology (HP:0012439)	2.08922810
55	Cerebral hypomyelination (HP:0006808)	2.08747967
56	Colon cancer (HP:0003003)	2.07863945
57	Attenuation of retinal blood vessels (HP:0007843)	2.07425619
58	Optic disc pallor (HP:0000543)	2.07224791
59	Inability to walk (HP:0002540)	2.06622083
60	Abnormality of homocysteine metabolism (HP:0010919)	2.04892311
61	Homocystinuria (HP:0002156)	2.04892311
62	Hepatic necrosis (HP:0002605)	2.03696016
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02319565
64	Abnormal lung lobation (HP:0002101)	2.00735009
65	Renal Fanconi syndrome (HP:0001994)	2.00404470
66	Cerebral edema (HP:0002181)	1.99602840
67	Lethargy (HP:0001254)	1.99162755
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99116619
69	Methylmalonic aciduria (HP:0012120)	1.97041402
70	Male pseudohermaphroditism (HP:0000037)	1.96013021
71	Lactic acidosis (HP:0003128)	1.95353861
72	Hyperglycinuria (HP:0003108)	1.94856892
73	Abnormality of the renal cortex (HP:0011035)	1.92412211
74	Combined immunodeficiency (HP:0005387)	1.91463015
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.88670095
76	IgG deficiency (HP:0004315)	1.88170752
77	Abnormality of chromosome stability (HP:0003220)	1.87247534
78	Hyperinsulinemic hypoglycemia (HP:0000825)	1.86383801
79	Abolished electroretinogram (ERG) (HP:0000550)	1.84038482
80	Ependymoma (HP:0002888)	1.84010802
81	Hyperglycinemia (HP:0002154)	1.83626817
82	Abnormality of serum amino acid levels (HP:0003112)	1.83554164
83	Ketoacidosis (HP:0001993)	1.83297995
84	Agitation (HP:0000713)	1.82129047
85	Abnormal number of erythroid precursors (HP:0012131)	1.79308127
86	Abnormality of glycine metabolism (HP:0010895)	1.77965799
87	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77965799
88	Pancytopenia (HP:0001876)	1.77456951
89	Female pseudohermaphroditism (HP:0010458)	1.77040163
90	Abnormal drinking behavior (HP:0030082)	1.76047272
91	Polydipsia (HP:0001959)	1.76047272
92	Small intestinal stenosis (HP:0012848)	1.74758280
93	Duodenal stenosis (HP:0100867)	1.74758280
94	Ectopic kidney (HP:0000086)	1.72281217
95	Hypoglycemic seizures (HP:0002173)	1.71720258
96	Carpal bone hypoplasia (HP:0001498)	1.69271091
97	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.69253268
98	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.69253268
99	Type I transferrin isoform profile (HP:0003642)	1.68624749
100	Type II lissencephaly (HP:0007260)	1.67838168

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	3.75681209
2	NUAK1	3.62350775
3	PBK	3.09777354
4	BUB1	3.09713844
5	EIF2AK3	3.08044641
6	VRK2	2.75007033
7	SRPK1	2.70923007
8	EIF2AK1	2.58609190
9	ZAK	2.49795402
10	WNK3	2.42384265
11	MST4	2.24745186
12	ACVR1B	2.21182715
13	FRK	2.19504196
14	PLK3	2.03374092
15	TXK	1.98057866
16	MKNK1	1.93120890
17	MAP4K2	1.87165971
18	VRK1	1.80412203
19	MKNK2	1.79021579
20	CDC7	1.67906630
21	INSRR	1.66822559
22	PLK4	1.66447209
23	BMPR1B	1.65003920
24	ADRBK2	1.57339481
25	TNIK	1.42687691
26	WNK4	1.37904234
27	NEK1	1.33923140
28	TRIM28	1.26478282
29	MAP3K4	1.26021677
30	TLK1	1.25073099
31	BRSK2	1.22209642
32	PASK	1.20857292
33	GRK1	1.18953493
34	MAP2K7	1.13691423
35	STK39	1.11300237
36	PLK1	1.09583020
37	CSNK1G1	1.07682047
38	OXSR1	1.06727704
39	PINK1	1.04908370
40	PLK2	1.04777784
41	EIF2AK2	1.02921281
42	FGFR2	0.96694682
43	WEE1	0.95575879
44	TTK	0.93234799
45	STK16	0.93104334
46	MAP3K12	0.89766156
47	CSNK1G3	0.77169080
48	MAPKAPK3	0.76139232
49	BRD4	0.75542069
50	TIE1	0.74610249
51	IRAK1	0.74382815
52	STK38L	0.74295483
53	MAPK13	0.73714981
54	ALK	0.73641280
55	IKBKB	0.72988587
56	ITK	0.71500686
57	ERBB3	0.70949591
58	DYRK2	0.70462553
59	LATS1	0.70020416
60	NLK	0.67477876
61	CSNK1A1L	0.65933401
62	FGFR1	0.65732783
63	TGFBR1	0.65017186
64	MINK1	0.62609875
65	TAF1	0.59234638
66	STK4	0.56472705
67	MAPKAPK5	0.54268215
68	CSNK1G2	0.53826628
69	PKN1	0.53435167
70	BCKDK	0.53317674
71	PAK3	0.53212937
72	PNCK	0.50119464
73	NME1	0.47821586
74	CAMKK2	0.47105187
75	ATR	0.46990241
76	ADRBK1	0.43921443
77	TAOK3	0.43617437
78	NEK6	0.43538789
79	PHKG2	0.41897025
80	PHKG1	0.41897025
81	TEC	0.41476980
82	PIK3CA	0.41010692
83	DAPK1	0.39712008
84	PRKCQ	0.39678530
85	TNK2	0.39319938
86	PRKAA2	0.38103750
87	MAPK15	0.37166805
88	PDK2	0.37015813
89	ATM	0.36136458
90	MAP2K6	0.35895007
91	RPS6KA5	0.35865348
92	PRKCG	0.34436952
93	PRKG1	0.34124237
94	BCR	0.33601423
95	CSNK2A1	0.31365937
96	STK3	0.31300979
97	STK24	0.29513765
98	CHUK	0.29285709
99	AURKB	0.27991603
100	CSNK1E	0.25894153

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.78452245
2	RNA polymerase_Homo sapiens_hsa03020	3.12156550
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.93321986
4	Protein export_Homo sapiens_hsa03060	2.72131254
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57333773
6	Homologous recombination_Homo sapiens_hsa03440	2.40368936
7	One carbon pool by folate_Homo sapiens_hsa00670	2.32807297
8	Mismatch repair_Homo sapiens_hsa03430	2.27667995
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25866586
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.25224469
11	Parkinsons disease_Homo sapiens_hsa05012	2.23132903
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04982499
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.92360731
14	Phototransduction_Homo sapiens_hsa04744	1.89541464
15	Basal transcription factors_Homo sapiens_hsa03022	1.85064461
16	Propanoate metabolism_Homo sapiens_hsa00640	1.82298696
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81894966
18	Caffeine metabolism_Homo sapiens_hsa00232	1.80732816
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.78400148
20	RNA degradation_Homo sapiens_hsa03018	1.65336912
21	RNA transport_Homo sapiens_hsa03013	1.63567071
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54020459
23	DNA replication_Homo sapiens_hsa03030	1.53727844
24	Spliceosome_Homo sapiens_hsa03040	1.53600488
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52198413
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49188388
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46153156
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45442408
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42918327
30	Huntingtons disease_Homo sapiens_hsa05016	1.42799917
31	Sulfur metabolism_Homo sapiens_hsa00920	1.42363877
32	Butanoate metabolism_Homo sapiens_hsa00650	1.39653080
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.37489005
34	Base excision repair_Homo sapiens_hsa03410	1.36918559
35	Fatty acid elongation_Homo sapiens_hsa00062	1.35496507
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.28119877
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.28048423
38	Ribosome_Homo sapiens_hsa03010	1.26041425
39	Alzheimers disease_Homo sapiens_hsa05010	1.17626391
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16940214
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13488389
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.13129717
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11302857
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.08821856
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06503847
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.01724639
47	Purine metabolism_Homo sapiens_hsa00230	1.01650676
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97439831
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92076250
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.91137284
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.90337336
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87563809
53	Asthma_Homo sapiens_hsa05310	0.85949759
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85512567
55	Allograft rejection_Homo sapiens_hsa05330	0.83787111
56	Cell cycle_Homo sapiens_hsa04110	0.81827886
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81160791
58	Peroxisome_Homo sapiens_hsa04146	0.76080810
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74576052
60	Nicotine addiction_Homo sapiens_hsa05033	0.73726748
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71572247
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69805890
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69293529
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67597532
65	Metabolic pathways_Homo sapiens_hsa01100	0.61749407
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61720613
67	Retinol metabolism_Homo sapiens_hsa00830	0.61449788
68	Olfactory transduction_Homo sapiens_hsa04740	0.60599351
69	Regulation of autophagy_Homo sapiens_hsa04140	0.60272611
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59507905
71	p53 signaling pathway_Homo sapiens_hsa04115	0.57230071
72	Glutathione metabolism_Homo sapiens_hsa00480	0.55955286
73	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55221878
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.55215934
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55000748
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53892842
77	Taste transduction_Homo sapiens_hsa04742	0.53868632
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51992610
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49290584
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46703528
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43922828
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42284088
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41581838
84	Mineral absorption_Homo sapiens_hsa04978	0.40353433
85	Oocyte meiosis_Homo sapiens_hsa04114	0.40154534
86	Fatty acid degradation_Homo sapiens_hsa00071	0.39793726
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37629060
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37507126
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36922849
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.36211714
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35576020
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33845268
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32893309
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.32209354
95	Serotonergic synapse_Homo sapiens_hsa04726	0.31939149
96	Sulfur relay system_Homo sapiens_hsa04122	0.31287601
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29946300
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29279527
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26534958
100	mRNA surveillance pathway_Homo sapiens_hsa03015	0.26288984

FAM60BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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