FAM60CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)7.02151323
2rRNA modification (GO:0000154)5.60133733
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.39851104
4protein neddylation (GO:0045116)5.39644688
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19880142
6rRNA methylation (GO:0031167)5.18429574
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.17977056
8ATP synthesis coupled proton transport (GO:0015986)5.17977056
9maturation of 5.8S rRNA (GO:0000460)4.75138025
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53234071
11DNA deamination (GO:0045006)4.48447187
12chaperone-mediated protein transport (GO:0072321)4.33839624
13termination of RNA polymerase III transcription (GO:0006386)4.33567195
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.33567195
15GTP biosynthetic process (GO:0006183)4.06870721
16pseudouridine synthesis (GO:0001522)3.95929191
17somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.94463625
18somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.94463625
19isotype switching (GO:0045190)3.94463625
20cullin deneddylation (GO:0010388)3.93208757
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.91153405
22regulation of mitotic spindle checkpoint (GO:1903504)3.91153405
23respiratory chain complex IV assembly (GO:0008535)3.77982855
24protein complex biogenesis (GO:0070271)3.72040978
25protein deneddylation (GO:0000338)3.71571167
26mitochondrial respiratory chain complex assembly (GO:0033108)3.71025546
27DNA damage response, detection of DNA damage (GO:0042769)3.61896463
28respiratory electron transport chain (GO:0022904)3.61710935
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59227266
30electron transport chain (GO:0022900)3.58355464
31protein targeting to mitochondrion (GO:0006626)3.55911735
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55015056
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.55015056
34NADH dehydrogenase complex assembly (GO:0010257)3.55015056
35cytochrome complex assembly (GO:0017004)3.52432838
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51200071
37UTP biosynthetic process (GO:0006228)3.51018430
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50706748
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50156724
40ribosomal large subunit biogenesis (GO:0042273)3.49684280
41CTP biosynthetic process (GO:0006241)3.47310032
42CTP metabolic process (GO:0046036)3.47310032
43pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.47265617
44regulation of immunoglobulin secretion (GO:0051023)3.46124688
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37309360
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37309360
47protein localization to mitochondrion (GO:0070585)3.35846091
48ATP biosynthetic process (GO:0006754)3.33619866
49establishment of protein localization to mitochondrion (GO:0072655)3.31399878
50ribonucleoside triphosphate biosynthetic process (GO:0009201)3.26118150
51regulation of mitochondrial translation (GO:0070129)3.23727273
52DNA ligation (GO:0006266)3.21390718
53tRNA processing (GO:0008033)3.21145654
54organelle disassembly (GO:1903008)3.20392750
55pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.19982376
56regulation of cellular amino acid metabolic process (GO:0006521)3.18644877
57rRNA processing (GO:0006364)3.17650750
58response to pheromone (GO:0019236)3.14337025
59UTP metabolic process (GO:0046051)3.14304541
60mitochondrial RNA metabolic process (GO:0000959)3.13260868
61rRNA metabolic process (GO:0016072)3.10411316
62pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.10281193
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07150114
64histone mRNA metabolic process (GO:0008334)3.03676915
65spliceosomal snRNP assembly (GO:0000387)3.03310021
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02902339
67somatic recombination of immunoglobulin gene segments (GO:0016447)3.00565837
68nucleoside triphosphate biosynthetic process (GO:0009142)3.00486913
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99550616
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99550616
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99550616
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97659569
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97642078
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97642078
75spliceosomal complex assembly (GO:0000245)2.97565558
76somatic diversification of immunoglobulins (GO:0016445)2.97527373
77chromatin remodeling at centromere (GO:0031055)2.97492155
78intracellular protein transmembrane import (GO:0044743)2.96715262
79DNA double-strand break processing (GO:0000729)2.95688561
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.86328957
81transcription from mitochondrial promoter (GO:0006390)2.86121605
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85427504
83signal transduction involved in DNA damage checkpoint (GO:0072422)2.85427504
84pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.85372919
85protein-cofactor linkage (GO:0018065)2.83283325
86hydrogen ion transmembrane transport (GO:1902600)2.81619081
87tRNA metabolic process (GO:0006399)2.81420612
88aldehyde catabolic process (GO:0046185)2.80694437
89regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.78370847
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78352386
91water-soluble vitamin biosynthetic process (GO:0042364)2.77873251
92CENP-A containing nucleosome assembly (GO:0034080)2.76917421
93transcription elongation from RNA polymerase I promoter (GO:0006362)2.75242458
94ncRNA processing (GO:0034470)2.74856595
95ncRNA metabolic process (GO:0034660)2.74754608
96nucleoside diphosphate phosphorylation (GO:0006165)2.73488934
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71435396
98somatic diversification of immune receptors (GO:0002200)2.70311671
99cellular component biogenesis (GO:0044085)2.70285961
100pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.70039882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92668984
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.46002900
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.82780174
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27228784
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12168797
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98591748
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.89535847
8VDR_23849224_ChIP-Seq_CD4+_Human2.74851140
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.72398143
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68270325
11ELK1_19687146_ChIP-ChIP_HELA_Human2.67694937
12VDR_22108803_ChIP-Seq_LS180_Human2.66878971
13EWS_26573619_Chip-Seq_HEK293_Human2.56862775
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53853454
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47787729
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46999649
17FOXP3_21729870_ChIP-Seq_TREG_Human2.22371638
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.17224131
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15430007
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13230989
21ZNF274_21170338_ChIP-Seq_K562_Hela2.10357777
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08143723
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.01139103
24IGF1R_20145208_ChIP-Seq_DFB_Human1.97222702
25MYC_18940864_ChIP-ChIP_HL60_Human1.97128249
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92826054
27TTF2_22483619_ChIP-Seq_HELA_Human1.88408803
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86830280
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85618295
30FUS_26573619_Chip-Seq_HEK293_Human1.82233552
31DCP1A_22483619_ChIP-Seq_HELA_Human1.78095150
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76379252
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.76137604
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70478489
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64121847
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61891540
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55856417
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.54846614
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54772619
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51879763
41TP53_22573176_ChIP-Seq_HFKS_Human1.50921702
42GABP_19822575_ChIP-Seq_HepG2_Human1.50602955
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46761754
44IRF1_19129219_ChIP-ChIP_H3396_Human1.45291995
45TAF15_26573619_Chip-Seq_HEK293_Human1.42997099
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40942191
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.38871527
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38447182
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34973872
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33466083
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33372215
52P300_19829295_ChIP-Seq_ESCs_Human1.27781812
53XRN2_22483619_ChIP-Seq_HELA_Human1.27767937
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26913018
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.26290151
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26290151
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23281640
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23065112
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.22906001
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22102958
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20952140
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18953887
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15241463
64ER_23166858_ChIP-Seq_MCF-7_Human1.13914486
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12917917
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12509323
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12305978
68NCOR_22424771_ChIP-Seq_293T_Human1.11865534
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.11751692
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.10451436
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08249975
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07882508
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07078760
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06877126
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04398605
76CBP_20019798_ChIP-Seq_JUKART_Human1.04318073
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04318073
78NANOG_19829295_ChIP-Seq_ESCs_Human1.03340338
79SOX2_19829295_ChIP-Seq_ESCs_Human1.03340338
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03114979
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02631263
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02127589
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02058815
84ERG_20517297_ChIP-Seq_VCAP_Human0.96901378
85HTT_18923047_ChIP-ChIP_STHdh_Human0.94087338
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93268287
87AR_20517297_ChIP-Seq_VCAP_Human0.93179087
88HOXB7_26014856_ChIP-Seq_BT474_Human0.93058915
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.90670017
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89059265
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88974095
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87848310
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.87459690
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87159184
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86463261
96TCF4_22108803_ChIP-Seq_LS180_Human0.86142927
97KDM5A_27292631_Chip-Seq_BREAST_Human0.85018916
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83959193
99MYC_19829295_ChIP-Seq_ESCs_Human0.83693041
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81543950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.21006768
2MP0006292_abnormal_olfactory_placode3.25347230
3MP0001986_abnormal_taste_sensitivity2.97304478
4MP0008875_abnormal_xenobiotic_pharmacok2.45036413
5MP0001968_abnormal_touch/_nociception2.41077088
6MP0002736_abnormal_nociception_after2.30949015
7MP0005646_abnormal_pituitary_gland2.21530700
8MP0003195_calcinosis2.17584265
9MP0005084_abnormal_gallbladder_morpholo2.11055635
10MP0003880_abnormal_central_pattern2.00285934
11MP0008872_abnormal_physiological_respon1.94169690
12MP0002837_dystrophic_cardiac_calcinosis1.89289995
13MP0003693_abnormal_embryo_hatching1.85058873
14MP0008058_abnormal_DNA_repair1.84311600
15MP0008007_abnormal_cellular_replicative1.82878509
16MP0005671_abnormal_response_to1.81260608
17MP0003787_abnormal_imprinting1.78797138
18MP0006036_abnormal_mitochondrial_physio1.77316521
19MP0005645_abnormal_hypothalamus_physiol1.72461111
20MP0006072_abnormal_retinal_apoptosis1.71113523
21MP0008057_abnormal_DNA_replication1.70357970
22MP0000516_abnormal_urinary_system1.66238908
23MP0005367_renal/urinary_system_phenotyp1.66238908
24MP0006276_abnormal_autonomic_nervous1.66181461
25MP0002102_abnormal_ear_morphology1.63467573
26MP0004957_abnormal_blastocyst_morpholog1.63462918
27MP0001529_abnormal_vocalization1.60357396
28MP0005423_abnormal_somatic_nervous1.57732992
29MP0004147_increased_porphyrin_level1.57496707
30MP0004885_abnormal_endolymph1.57003061
31MP0003786_premature_aging1.55072460
32MP0003718_maternal_effect1.54471409
33MP0005083_abnormal_biliary_tract1.54287956
34MP0010094_abnormal_chromosome_stability1.53909395
35MP0005551_abnormal_eye_electrophysiolog1.47736427
36MP0000631_abnormal_neuroendocrine_gland1.46201131
37MP0001501_abnormal_sleep_pattern1.44879375
38MP0002272_abnormal_nervous_system1.44870570
39MP0005253_abnormal_eye_physiology1.42628537
40MP0006035_abnormal_mitochondrial_morpho1.35508810
41MP0003045_fibrosis1.35285925
42MP0009046_muscle_twitch1.34575514
43MP0005410_abnormal_fertilization1.34038305
44MP0002751_abnormal_autonomic_nervous1.32917291
45MP0002163_abnormal_gland_morphology1.32912184
46MP0003122_maternal_imprinting1.31328234
47MP0003646_muscle_fatigue1.26742901
48MP0003567_abnormal_fetal_cardiomyocyte1.25886122
49MP0004142_abnormal_muscle_tone1.19189795
50MP0000049_abnormal_middle_ear1.18578047
51MP0009785_altered_susceptibility_to1.14485176
52MP0002638_abnormal_pupillary_reflex1.12167201
53MP0001764_abnormal_homeostasis1.08993143
54MP0008932_abnormal_embryonic_tissue1.07931103
55MP0004145_abnormal_muscle_electrophysio1.07024318
56MP0003011_delayed_dark_adaptation1.04900172
57MP0003121_genomic_imprinting1.04737870
58MP0001835_abnormal_antigen_presentation1.04657594
59MP0009745_abnormal_behavioral_response1.03814132
60MP0002234_abnormal_pharynx_morphology1.03780444
61MP0004215_abnormal_myocardial_fiber1.02698739
62MP0002210_abnormal_sex_determination0.99937736
63MP0002160_abnormal_reproductive_system0.98690422
64MP0002938_white_spotting0.98417455
65MP0008789_abnormal_olfactory_epithelium0.96928433
66MP0001905_abnormal_dopamine_level0.95743937
67MP0005187_abnormal_penis_morphology0.94970625
68MP0003119_abnormal_digestive_system0.93471816
69MP0005389_reproductive_system_phenotype0.90538672
70MP0000653_abnormal_sex_gland0.87904012
71MP0003137_abnormal_impulse_conducting0.87418145
72MP0001293_anophthalmia0.86167601
73MP0001929_abnormal_gametogenesis0.84839111
74MP0001119_abnormal_female_reproductive0.82962617
75MP0002733_abnormal_thermal_nociception0.82458226
76MP0002735_abnormal_chemical_nociception0.81636082
77MP0001970_abnormal_pain_threshold0.80157344
78MP0001145_abnormal_male_reproductive0.79414535
79MP0004133_heterotaxia0.76673177
80MP0001485_abnormal_pinna_reflex0.76513827
81MP0001963_abnormal_hearing_physiology0.72724122
82MP0001486_abnormal_startle_reflex0.72015086
83MP0005395_other_phenotype0.71236907
84MP0001879_abnormal_lymphatic_vessel0.70569454
85MP0002752_abnormal_somatic_nervous0.70012148
86MP0000685_abnormal_immune_system0.69411040
87MP0003186_abnormal_redox_activity0.68470086
88MP0002572_abnormal_emotion/affect_behav0.68258170
89MP0003111_abnormal_nucleus_morphology0.67652868
90MP0005195_abnormal_posterior_eye0.67451036
91MP0002067_abnormal_sensory_capabilities0.66956487
92MP0000372_irregular_coat_pigmentation0.66271212
93MP0001919_abnormal_reproductive_system0.65940683
94MP0010386_abnormal_urinary_bladder0.65301948
95MP0001984_abnormal_olfaction0.64443352
96MP0003938_abnormal_ear_development0.63746244
97MP0003698_abnormal_male_reproductive0.63536036
98MP0002229_neurodegeneration0.62968823
99MP0005391_vision/eye_phenotype0.62492913
100MP0009379_abnormal_foot_pigmentation0.61595578

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.13126316
2Acute necrotizing encephalopathy (HP:0006965)4.81289846
33-Methylglutaconic aciduria (HP:0003535)4.75874714
4Acute encephalopathy (HP:0006846)4.34977593
5Abnormal mitochondria in muscle tissue (HP:0008316)4.11558109
6Progressive macrocephaly (HP:0004481)3.97688284
7Mitochondrial inheritance (HP:0001427)3.96963506
8Increased CSF lactate (HP:0002490)3.67777445
9Hepatocellular necrosis (HP:0001404)3.59477459
10Pancreatic cysts (HP:0001737)3.53755533
11Molar tooth sign on MRI (HP:0002419)3.53495706
12Abnormality of midbrain morphology (HP:0002418)3.53495706
13Cerebral edema (HP:0002181)3.32552058
14Hepatic necrosis (HP:0002605)3.28008070
15Pancreatic fibrosis (HP:0100732)3.11371969
16IgG deficiency (HP:0004315)3.07717220
17Hyperglycinemia (HP:0002154)2.82805903
18Abnormality of the pons (HP:0007361)2.75637013
19Increased IgM level (HP:0003496)2.73184791
20Median cleft lip (HP:0000161)2.69622910
21Multiple enchondromatosis (HP:0005701)2.65835439
22True hermaphroditism (HP:0010459)2.65016782
23Increased serum lactate (HP:0002151)2.60657052
24Medial flaring of the eyebrow (HP:0010747)2.59243115
25Optic disc pallor (HP:0000543)2.57138379
26Nephronophthisis (HP:0000090)2.54065971
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52966125
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52966125
29Abnormality of the anterior horn cell (HP:0006802)2.51214242
30Degeneration of anterior horn cells (HP:0002398)2.51214242
31Hyperglycinuria (HP:0003108)2.47832782
32Methylmalonic acidemia (HP:0002912)2.36335559
33Respiratory failure (HP:0002878)2.35992390
34Cortical visual impairment (HP:0100704)2.33248803
35Abnormality of the renal cortex (HP:0011035)2.33147552
36Lactic acidosis (HP:0003128)2.32294707
37Congenital, generalized hypertrichosis (HP:0004540)2.31939677
38Lipid accumulation in hepatocytes (HP:0006561)2.26139864
39Polyuria (HP:0000103)2.25587857
40Abnormality of the renal medulla (HP:0100957)2.24562369
41Abnormality of the renal collecting system (HP:0004742)2.24202237
42Abnormal drinking behavior (HP:0030082)2.24093177
43Polydipsia (HP:0001959)2.24093177
44Increased hepatocellular lipid droplets (HP:0006565)2.23968250
45Lethargy (HP:0001254)2.23774406
46Parakeratosis (HP:0001036)2.23202082
47Hypochromic microcytic anemia (HP:0004840)2.21328906
48Stenosis of the external auditory canal (HP:0000402)2.17956705
49Hypoproteinemia (HP:0003075)2.15220457
50Leukodystrophy (HP:0002415)2.13125720
51Posterior subcapsular cataract (HP:0007787)2.12419965
52Meckel diverticulum (HP:0002245)2.12184673
53Exercise intolerance (HP:0003546)2.11160616
54Broad alveolar ridges (HP:0000187)2.10729634
55Abnormality of the ileum (HP:0001549)2.08195351
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08022137
57Abnormality of glycine metabolism (HP:0010895)2.07235547
58Abnormality of serine family amino acid metabolism (HP:0010894)2.07235547
59Duplicated collecting system (HP:0000081)2.06696916
60Abnormality of the labia minora (HP:0012880)2.06244479
61Generalized aminoaciduria (HP:0002909)2.05702021
62Microvesicular hepatic steatosis (HP:0001414)2.03514641
63Sclerocornea (HP:0000647)2.03171081
64Anencephaly (HP:0002323)2.02983138
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01588991
66Abnormality of serum amino acid levels (HP:0003112)2.01099006
67Pendular nystagmus (HP:0012043)1.99267245
68Methylmalonic aciduria (HP:0012120)1.98207319
69Cystic liver disease (HP:0006706)1.97661823
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94648124
71Preaxial hand polydactyly (HP:0001177)1.94550429
72Triphalangeal thumb (HP:0001199)1.92174213
73Aplasia/hypoplasia of the uterus (HP:0008684)1.89646004
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87976266
75Absent thumb (HP:0009777)1.85060422
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.83014281
77CNS demyelination (HP:0007305)1.79487472
78Abnormality of methionine metabolism (HP:0010901)1.77924292
79Renal Fanconi syndrome (HP:0001994)1.77885470
80Ectopic kidney (HP:0000086)1.76364695
81Hypoplasia of the pons (HP:0012110)1.75522962
82Abnormal urine output (HP:0012590)1.75059702
83Cerebral hypomyelination (HP:0006808)1.74982522
84Large for gestational age (HP:0001520)1.74745417
85Opisthotonus (HP:0002179)1.74646611
86Failure to thrive in infancy (HP:0001531)1.74083513
87Absent septum pellucidum (HP:0001331)1.73431931
88Limb dystonia (HP:0002451)1.72811279
89Abnormality of alanine metabolism (HP:0010916)1.71559556
90Hyperalaninemia (HP:0003348)1.71559556
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71559556
92Severe combined immunodeficiency (HP:0004430)1.70929899
93Congenital stationary night blindness (HP:0007642)1.70810519
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.70579553
95Dicarboxylic aciduria (HP:0003215)1.69710949
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69710949
97Type 2 muscle fiber atrophy (HP:0003554)1.69396216
98Oral leukoplakia (HP:0002745)1.69181182
99Abnormality of T cell physiology (HP:0011840)1.68691587
100Reticulocytopenia (HP:0001896)1.68246914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.28155324
2VRK23.13437430
3TSSK63.13102398
4MKNK12.95886025
5ZAK2.94137230
6WNK32.49294214
7VRK12.43462467
8TLK12.39096552
9TXK2.33372747
10NME22.30022757
11SRPK12.16810859
12OXSR12.14014895
13STK392.09265787
14EIF2AK32.06007185
15MKNK22.04664938
16MST42.00546219
17NEK11.97350072
18EIF2AK11.95884985
19BCR1.88916602
20PLK31.86622226
21TAF11.81796165
22MAP4K21.78232209
23BUB11.65652432
24ADRBK21.60391538
25TRIM281.55410797
26GRK11.54789866
27PASK1.40704884
28MAP2K71.32691887
29STK161.31568799
30EIF2AK21.30860181
31TIE11.30448083
32WNK41.29550913
33MAP3K41.29214614
34MAPK131.26487447
35FRK1.25749820
36CSNK1G31.18159542
37DYRK21.18103022
38BMPR1B1.14787271
39PLK21.11311482
40CSNK1A1L1.08281851
41WEE11.04491797
42RPS6KA51.02321669
43CSNK1G11.00135292
44PLK40.94354773
45CSNK1G20.87957028
46MAPKAPK50.87420177
47PDK20.85478198
48INSRR0.84899149
49ERBB30.84887452
50KDR0.84722159
51PIM20.84522638
52PLK10.79984962
53CDK190.77476208
54TAOK30.77321481
55IKBKB0.71978476
56CDC70.71089724
57PHKG20.69869252
58PHKG10.69869252
59NME10.67299566
60TNIK0.65413364
61MAP3K120.63935077
62ALK0.62564331
63PRKCG0.59378810
64ATR0.56770374
65MINK10.53516753
66CSNK2A10.51782080
67TNK20.51725369
68FGFR30.50596080
69AURKB0.49862914
70CSNK1E0.46550167
71TEC0.46399515
72PRKCQ0.46271674
73CSNK2A20.46114321
74CAMK2A0.45866694
75ABL20.45122187
76CAMKK20.44135706
77DAPK30.41410125
78DYRK1A0.40538971
79PIM10.38960145
80PINK10.37737042
81IKBKE0.37579135
82CSNK1A10.36600219
83ADRBK10.36560344
84GRK50.36308942
85CHUK0.35386627
86PRKACA0.34936818
87ATM0.33498803
88CSNK1D0.33445884
89PRKACB0.32718334
90PKN10.32508077
91OBSCN0.31505292
92PRKG10.31375133
93NEK60.31361911
94CAMK10.30485619
95EPHA30.29228975
96TGFBR20.28423209
97BCKDK0.28067494
98PRKCA0.27914042
99MYLK0.25095442
100LYN0.24380658

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01723683
2Oxidative phosphorylation_Homo sapiens_hsa001903.91069093
3RNA polymerase_Homo sapiens_hsa030203.11415109
4Parkinsons disease_Homo sapiens_hsa050123.09606279
5Ribosome_Homo sapiens_hsa030102.96506893
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50697336
7Propanoate metabolism_Homo sapiens_hsa006402.39090644
8Protein export_Homo sapiens_hsa030602.33094341
9Huntingtons disease_Homo sapiens_hsa050162.17555336
10Mismatch repair_Homo sapiens_hsa034302.17157647
11One carbon pool by folate_Homo sapiens_hsa006702.11038845
12DNA replication_Homo sapiens_hsa030302.07013803
13Alzheimers disease_Homo sapiens_hsa050101.94759427
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92144449
15RNA degradation_Homo sapiens_hsa030181.88925064
16Basal transcription factors_Homo sapiens_hsa030221.87386089
17RNA transport_Homo sapiens_hsa030131.75993130
18Nucleotide excision repair_Homo sapiens_hsa034201.75486650
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73938127
20Homologous recombination_Homo sapiens_hsa034401.71328903
21Pyrimidine metabolism_Homo sapiens_hsa002401.71132933
22Spliceosome_Homo sapiens_hsa030401.67989683
23Caffeine metabolism_Homo sapiens_hsa002321.65293550
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.62328064
25Vitamin B6 metabolism_Homo sapiens_hsa007501.60053501
26Asthma_Homo sapiens_hsa053101.58334712
27Collecting duct acid secretion_Homo sapiens_hsa049661.52779879
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51085505
29Linoleic acid metabolism_Homo sapiens_hsa005911.47133342
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42532367
31Primary immunodeficiency_Homo sapiens_hsa053401.41900463
32Fanconi anemia pathway_Homo sapiens_hsa034601.40044129
33Cardiac muscle contraction_Homo sapiens_hsa042601.37980407
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36248017
35Phototransduction_Homo sapiens_hsa047441.33211521
36Base excision repair_Homo sapiens_hsa034101.31879360
37Purine metabolism_Homo sapiens_hsa002301.25532461
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19182592
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18833508
40Autoimmune thyroid disease_Homo sapiens_hsa053201.18047280
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.14424073
42Allograft rejection_Homo sapiens_hsa053301.13324463
43Nitrogen metabolism_Homo sapiens_hsa009101.06578432
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02205100
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97863508
46Pyruvate metabolism_Homo sapiens_hsa006200.92868613
47Tryptophan metabolism_Homo sapiens_hsa003800.92397772
48Taste transduction_Homo sapiens_hsa047420.88937472
49Non-homologous end-joining_Homo sapiens_hsa034500.88198869
50Sulfur relay system_Homo sapiens_hsa041220.87462532
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86073833
52Butanoate metabolism_Homo sapiens_hsa006500.84356488
53Rheumatoid arthritis_Homo sapiens_hsa053230.80587016
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77581495
55Metabolic pathways_Homo sapiens_hsa011000.71487101
56Retinol metabolism_Homo sapiens_hsa008300.71250820
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69721356
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68102464
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66976575
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.66637115
61Arachidonic acid metabolism_Homo sapiens_hsa005900.64599307
62beta-Alanine metabolism_Homo sapiens_hsa004100.62988129
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62668331
64Selenocompound metabolism_Homo sapiens_hsa004500.62287985
65Nicotine addiction_Homo sapiens_hsa050330.60157569
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59598542
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58375508
68Ether lipid metabolism_Homo sapiens_hsa005650.56297577
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53894958
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51898432
71Graft-versus-host disease_Homo sapiens_hsa053320.50611536
72Sulfur metabolism_Homo sapiens_hsa009200.50519118
73Chemical carcinogenesis_Homo sapiens_hsa052040.50448467
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50217031
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49363013
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.48858392
77Systemic lupus erythematosus_Homo sapiens_hsa053220.47815686
78Fatty acid degradation_Homo sapiens_hsa000710.47181580
79Peroxisome_Homo sapiens_hsa041460.45915640
80Glutathione metabolism_Homo sapiens_hsa004800.44009516
81Type I diabetes mellitus_Homo sapiens_hsa049400.43164308
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43116615
83Epstein-Barr virus infection_Homo sapiens_hsa051690.41579310
84Fatty acid elongation_Homo sapiens_hsa000620.41560982
85mRNA surveillance pathway_Homo sapiens_hsa030150.39661800
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38158757
87Glycerolipid metabolism_Homo sapiens_hsa005610.35654675
88Cell cycle_Homo sapiens_hsa041100.32379107
89Steroid biosynthesis_Homo sapiens_hsa001000.31453278
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31217268
91Fat digestion and absorption_Homo sapiens_hsa049750.28625258
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25699950
93Tyrosine metabolism_Homo sapiens_hsa003500.25343318
94Arginine and proline metabolism_Homo sapiens_hsa003300.24887237
95Olfactory transduction_Homo sapiens_hsa047400.24537813
96Morphine addiction_Homo sapiens_hsa050320.23877364
97Fatty acid metabolism_Homo sapiens_hsa012120.23490497
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22071231
99Malaria_Homo sapiens_hsa051440.20710580
100Carbon metabolism_Homo sapiens_hsa012000.19015280

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »