FAM60DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)8.65564665
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.84451795
3monoubiquitinated protein deubiquitination (GO:0035520)5.61840160
4membrane repolarization during action potential (GO:0086011)5.45893885
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.45207724
6regulation of DNA endoreduplication (GO:0032875)5.37225906
7parturition (GO:0007567)4.95949083
8negative regulation of response to food (GO:0032096)4.76489834
9negative regulation of appetite (GO:0032099)4.76489834
10water-soluble vitamin biosynthetic process (GO:0042364)4.59341816
11cell proliferation in forebrain (GO:0021846)4.45095085
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.42335020
13negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.38282734
14serotonin metabolic process (GO:0042428)4.27143359
15magnesium ion transport (GO:0015693)4.23709887
16membrane repolarization (GO:0086009)4.22947155
17fat-soluble vitamin catabolic process (GO:0042363)4.13852606
18vitamin catabolic process (GO:0009111)4.13852606
19protein complex biogenesis (GO:0070271)4.11738513
20cellular anion homeostasis (GO:0030002)4.09556586
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.97604377
22negative regulation of transcription regulatory region DNA binding (GO:2000678)3.96198642
23regulation of membrane repolarization (GO:0060306)3.94976580
24primary amino compound metabolic process (GO:1901160)3.91568975
25tooth mineralization (GO:0034505)3.88394240
26negative regulation of membrane potential (GO:0045837)3.76072981
27negative regulation of DNA-templated transcription, elongation (GO:0032785)3.61840879
28mitochondrial respiratory chain complex assembly (GO:0033108)3.59117693
29cellular response to electrical stimulus (GO:0071257)3.55498348
30spinal cord development (GO:0021510)3.47484468
31dendritic spine morphogenesis (GO:0060997)3.43971152
32indolalkylamine metabolic process (GO:0006586)3.40502934
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38002660
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.38002660
35NADH dehydrogenase complex assembly (GO:0010257)3.38002660
36positive regulation of fatty acid oxidation (GO:0046321)3.34179893
37positive regulation of synapse maturation (GO:0090129)3.28703710
38glyoxylate metabolic process (GO:0046487)3.26018575
39negative regulation of systemic arterial blood pressure (GO:0003085)3.23308073
40protein K48-linked deubiquitination (GO:0071108)3.22574676
41retinal ganglion cell axon guidance (GO:0031290)3.19929825
42substrate-independent telencephalic tangential migration (GO:0021826)3.14693485
43substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.14693485
44misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.12835454
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11440559
46regulation of sequestering of triglyceride (GO:0010889)3.10452992
47trivalent inorganic anion homeostasis (GO:0072506)3.09903201
48phosphate ion homeostasis (GO:0055062)3.09903201
49cerebellar Purkinje cell differentiation (GO:0021702)3.06961775
50vitamin D metabolic process (GO:0042359)3.06421096
51protein import into peroxisome matrix (GO:0016558)3.05760665
52regulation of response to food (GO:0032095)3.03442126
53regulation of potassium ion transmembrane transport (GO:1901379)3.02532672
54regulation of fatty acid beta-oxidation (GO:0031998)3.01911718
55pyrimidine nucleobase catabolic process (GO:0006208)3.00923811
56base-excision repair, AP site formation (GO:0006285)2.97547739
57cellular potassium ion homeostasis (GO:0030007)2.93057148
58synaptic transmission, cholinergic (GO:0007271)2.91298620
59snRNA transcription (GO:0009301)2.90119236
60ovulation cycle (GO:0042698)2.88781787
61regulation of synapse maturation (GO:0090128)2.88107074
62gamma-aminobutyric acid transport (GO:0015812)2.86736084
63response to misfolded protein (GO:0051788)2.85779178
64negative regulation of protein localization to cell surface (GO:2000009)2.84046948
65positive regulation of endothelial cell differentiation (GO:0045603)2.81334935
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.81027368
67forebrain neuron differentiation (GO:0021879)2.80709800
68metanephric mesenchyme development (GO:0072075)2.79837414
69kidney mesenchyme development (GO:0072074)2.79451545
70regulation of appetite (GO:0032098)2.76502442
71protein neddylation (GO:0045116)2.76236821
72positive regulation of potassium ion transmembrane transport (GO:1901381)2.76040657
73transmission of nerve impulse (GO:0019226)2.73631188
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72928358
75chaperone-mediated protein transport (GO:0072321)2.72281193
76cellular response to exogenous dsRNA (GO:0071360)2.71582169
77vitamin A metabolic process (GO:0006776)2.70078381
78indole-containing compound metabolic process (GO:0042430)2.68106614
79positive regulation of gastrulation (GO:2000543)2.67965902
80negative regulation of response to extracellular stimulus (GO:0032105)2.65988870
81negative regulation of response to nutrient levels (GO:0032108)2.65988870
82nonmotile primary cilium assembly (GO:0035058)2.64312630
83pyrimidine nucleotide catabolic process (GO:0006244)2.61217058
84regulation of potassium ion transmembrane transporter activity (GO:1901016)2.60665562
85embryonic body morphogenesis (GO:0010172)2.59960476
86regulation of transcription regulatory region DNA binding (GO:2000677)2.59113506
87intracellular protein transmembrane import (GO:0044743)2.57889352
88middle ear morphogenesis (GO:0042474)2.56853589
89spinal cord association neuron differentiation (GO:0021527)2.55554166
90protein polyglutamylation (GO:0018095)2.54931036
91negative regulation of potassium ion transmembrane transport (GO:1901380)2.54642635
92chaperone-mediated protein complex assembly (GO:0051131)2.53762821
93outer ear morphogenesis (GO:0042473)2.53556970
94segment specification (GO:0007379)2.52152971
95positive regulation of cardiac muscle cell differentiation (GO:2000727)2.52139224
96sulfation (GO:0051923)2.52061901
97glomerulus development (GO:0032835)2.51859433
98limb development (GO:0060173)2.50314387
99appendage development (GO:0048736)2.50314387
100endoderm formation (GO:0001706)2.50284989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.50058335
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70778762
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.98176311
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95960378
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.86186738
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84463202
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84279913
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.79368710
9IRF1_19129219_ChIP-ChIP_H3396_Human2.68608612
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67781208
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.60367026
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49464766
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41000129
14REST_21632747_ChIP-Seq_MESCs_Mouse2.37844475
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36010936
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.28394771
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26597945
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26438156
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19074784
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16936181
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16936181
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.07519965
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03258533
24RNF2_27304074_Chip-Seq_NSC_Mouse2.01686868
25VDR_22108803_ChIP-Seq_LS180_Human1.82744659
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81787641
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81213865
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80227992
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79697244
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73675144
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73226819
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67306345
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65666320
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.63697077
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61881391
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.61597872
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59579878
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52519810
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.52397524
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.51893794
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39527265
42ZNF274_21170338_ChIP-Seq_K562_Hela1.35470184
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32384568
44TAF15_26573619_Chip-Seq_HEK293_Human1.30853784
45P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30601604
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.27023190
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25515681
48NCOR_22424771_ChIP-Seq_293T_Human1.24655680
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24628373
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23670087
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23670087
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22212772
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20902992
54GBX2_23144817_ChIP-Seq_PC3_Human1.20829496
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.20689414
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17723800
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16813393
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16133702
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.15836972
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15504404
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15059424
62EWS_26573619_Chip-Seq_HEK293_Human1.14016563
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13567201
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12490038
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11983470
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10181640
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08384303
68RXR_22108803_ChIP-Seq_LS180_Human1.03881347
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03456859
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02309124
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01991038
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00092823
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98487027
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98365982
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97043190
76FUS_26573619_Chip-Seq_HEK293_Human0.96026920
77TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95865753
78CTCF_27219007_Chip-Seq_Bcells_Human0.94843480
79TAL1_26923725_Chip-Seq_HPCs_Mouse0.93768135
80TAF2_19829295_ChIP-Seq_ESCs_Human0.93343892
81P300_19829295_ChIP-Seq_ESCs_Human0.93246608
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.92868567
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91161709
84CBP_20019798_ChIP-Seq_JUKART_Human0.89020716
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89020716
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87922255
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87918200
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86596298
89AR_25329375_ChIP-Seq_VCAP_Human0.86235311
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86056506
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85708434
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84923834
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84814094
94RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83317360
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81358457
96BCAT_22108803_ChIP-Seq_LS180_Human0.81324141
97STAT3_23295773_ChIP-Seq_U87_Human0.80551964
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78732384
99IGF1R_20145208_ChIP-Seq_DFB_Human0.77696793
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77201200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.20217253
2MP0002837_dystrophic_cardiac_calcinosis3.93827988
3MP0003123_paternal_imprinting3.81443465
4MP0006292_abnormal_olfactory_placode2.88391748
5MP0002160_abnormal_reproductive_system2.87749701
6MP0003122_maternal_imprinting2.72368988
7MP0004130_abnormal_muscle_cell2.63010164
8MP0003890_abnormal_embryonic-extraembry2.59169588
9MP0009379_abnormal_foot_pigmentation2.47940661
10MP0003121_genomic_imprinting2.41839678
11MP0003011_delayed_dark_adaptation2.41439641
12MP0002653_abnormal_ependyma_morphology2.40580402
13MP0003787_abnormal_imprinting2.10176588
14MP0005389_reproductive_system_phenotype1.95421201
15MP0001485_abnormal_pinna_reflex1.91096430
16MP0004742_abnormal_vestibular_system1.90953704
17MP0008775_abnormal_heart_ventricle1.88416545
18MP0001440_abnormal_grooming_behavior1.87116332
19MP0004133_heterotaxia1.85267678
20MP0009384_cardiac_valve_regurgitation1.79467808
21MP0000778_abnormal_nervous_system1.72970056
22MP0000049_abnormal_middle_ear1.66480620
23MP0008877_abnormal_DNA_methylation1.59994506
24MP0004185_abnormal_adipocyte_glucose1.54639552
25MP0001968_abnormal_touch/_nociception1.52924753
26MP0002736_abnormal_nociception_after1.52615700
27MP0004145_abnormal_muscle_electrophysio1.50518045
28MP0002272_abnormal_nervous_system1.50091342
29MP0006276_abnormal_autonomic_nervous1.48404280
30MP0003942_abnormal_urinary_system1.48092039
31MP0005423_abnormal_somatic_nervous1.48002817
32MP0008789_abnormal_olfactory_epithelium1.45893198
33MP0001188_hyperpigmentation1.45865359
34MP0004885_abnormal_endolymph1.44654414
35MP0003879_abnormal_hair_cell1.42902851
36MP0001853_heart_inflammation1.42166852
37MP0002163_abnormal_gland_morphology1.38023471
38MP0002733_abnormal_thermal_nociception1.35172803
39MP0004142_abnormal_muscle_tone1.32463235
40MP0002638_abnormal_pupillary_reflex1.29473510
41MP0002557_abnormal_social/conspecific_i1.28663782
42MP0000631_abnormal_neuroendocrine_gland1.28648796
43MP0003880_abnormal_central_pattern1.28426751
44MP0001970_abnormal_pain_threshold1.24981626
45MP0000569_abnormal_digit_pigmentation1.24903088
46MP0003136_yellow_coat_color1.24737318
47MP0002928_abnormal_bile_duct1.24537290
48MP0010030_abnormal_orbit_morphology1.23325923
49MP0000026_abnormal_inner_ear1.23040323
50MP0004019_abnormal_vitamin_homeostasis1.22113007
51MP0009745_abnormal_behavioral_response1.21563026
52MP0005551_abnormal_eye_electrophysiolog1.21467802
53MP0001905_abnormal_dopamine_level1.20492088
54MP0000537_abnormal_urethra_morphology1.19415702
55MP0005646_abnormal_pituitary_gland1.18343324
56MP0002184_abnormal_innervation1.15254341
57MP0002735_abnormal_chemical_nociception1.15135039
58MP0009046_muscle_twitch1.14602299
59MP0002572_abnormal_emotion/affect_behav1.13315538
60MP0001486_abnormal_startle_reflex1.12973739
61MP0000230_abnormal_systemic_arterial1.11472756
62MP0002876_abnormal_thyroid_physiology1.10908856
63MP0001542_abnormal_bone_strength1.10586384
64MP0005386_behavior/neurological_phenoty1.09246442
65MP0004924_abnormal_behavior1.09246442
66MP0003567_abnormal_fetal_cardiomyocyte1.08615196
67MP0000955_abnormal_spinal_cord1.08524985
68MP0002063_abnormal_learning/memory/cond1.07964675
69MP0003635_abnormal_synaptic_transmissio1.06335103
70MP0002067_abnormal_sensory_capabilities1.05698561
71MP0002938_white_spotting1.03715812
72MP0002064_seizures1.03117850
73MP0001963_abnormal_hearing_physiology1.01924189
74MP0002752_abnormal_somatic_nervous1.01282683
75MP0003937_abnormal_limbs/digits/tail_de0.99262797
76MP0009250_abnormal_appendicular_skeleto0.97948789
77MP0001919_abnormal_reproductive_system0.95788514
78MP0001879_abnormal_lymphatic_vessel0.95390080
79MP0002089_abnormal_postnatal_growth/wei0.94845123
80MP0002277_abnormal_respiratory_mucosa0.93424543
81MP0004085_abnormal_heartbeat0.91407240
82MP0000427_abnormal_hair_cycle0.91030357
83MP0002882_abnormal_neuron_morphology0.90940052
84MP0010386_abnormal_urinary_bladder0.90858932
85MP0002822_catalepsy0.90772104
86MP0003938_abnormal_ear_development0.88153271
87MP0002734_abnormal_mechanical_nocicepti0.87286367
88MP0005195_abnormal_posterior_eye0.87201331
89MP0009053_abnormal_anal_canal0.82816650
90MP0004215_abnormal_myocardial_fiber0.82690302
91MP0003755_abnormal_palate_morphology0.81326676
92MP0006072_abnormal_retinal_apoptosis0.77954999
93MP0002210_abnormal_sex_determination0.75649749
94MP0002229_neurodegeneration0.75333029
95MP0005394_taste/olfaction_phenotype0.74329872
96MP0005499_abnormal_olfactory_system0.74329872
97MP0002152_abnormal_brain_morphology0.74151772
98MP0001293_anophthalmia0.73845397
99MP0003119_abnormal_digestive_system0.73311180
100MP0003633_abnormal_nervous_system0.73177804

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)5.88599910
2Osteomalacia (HP:0002749)5.01170473
3Short femoral neck (HP:0100864)3.77852065
4Hyperglycinemia (HP:0002154)3.41358419
5Nephronophthisis (HP:0000090)3.32049282
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.29159043
7Short 4th metacarpal (HP:0010044)3.29159043
8Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.26770612
9Progressive cerebellar ataxia (HP:0002073)3.02283015
10Molar tooth sign on MRI (HP:0002419)2.85960482
11Abnormality of midbrain morphology (HP:0002418)2.85960482
12Stenosis of the external auditory canal (HP:0000402)2.82437755
13Mesomelia (HP:0003027)2.77549402
14Meningioma (HP:0002858)2.77492685
15Abnormality of the 4th metacarpal (HP:0010012)2.74738807
16Abnormality of the renal medulla (HP:0100957)2.73993525
17Methylmalonic acidemia (HP:0002912)2.73649584
18Decreased circulating renin level (HP:0003351)2.71863858
19Abnormality of the renal collecting system (HP:0004742)2.70598335
20True hermaphroditism (HP:0010459)2.69781132
21Methylmalonic aciduria (HP:0012120)2.67364565
22Abnormality of renal resorption (HP:0011038)2.64574265
23Abnormal pancreas size (HP:0012094)2.63140582
24Oligodontia (HP:0000677)2.58284863
25Hypoplasia of the ulna (HP:0003022)2.52501951
26Fibular hypoplasia (HP:0003038)2.52287340
27Vascular calcification (HP:0004934)2.52060693
28Abnormality of the corticospinal tract (HP:0002492)2.50468096
29Neoplasm of the adrenal cortex (HP:0100641)2.45783976
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44752436
31Septo-optic dysplasia (HP:0100842)2.43284094
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.40511760
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40511760
34Aplasia/hypoplasia of the femur (HP:0005613)2.40089516
35Periauricular skin pits (HP:0100277)2.39808283
36Preauricular pit (HP:0004467)2.39808283
37Hypoplasia of the uterus (HP:0000013)2.39603824
38Mesangial abnormality (HP:0001966)2.36973532
39Pancreatic fibrosis (HP:0100732)2.35605158
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.33739034
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.32724791
42Congenital, generalized hypertrichosis (HP:0004540)2.31497666
43Genetic anticipation (HP:0003743)2.29826706
44Agitation (HP:0000713)2.28521331
45Medial flaring of the eyebrow (HP:0010747)2.28312863
46Lip pit (HP:0100267)2.27365468
47Aplasia/Hypoplasia of the fibula (HP:0006492)2.26744629
48Abnormality of the phalanges of the 5th finger (HP:0004213)2.25631535
49Short tibia (HP:0005736)2.23846689
50Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.20252453
51Chronic hepatic failure (HP:0100626)2.19671328
52Rib fusion (HP:0000902)2.18727331
53Pancreatic cysts (HP:0001737)2.17895835
54Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.16182924
55Adrenal hypoplasia (HP:0000835)2.14757086
56Cardiovascular calcification (HP:0011915)2.14281458
57Radial bowing (HP:0002986)2.13127841
58Abnormality of the middle phalanges of the toes (HP:0010183)2.11831557
59Megalencephaly (HP:0001355)2.11825313
60Diastasis recti (HP:0001540)2.11274460
61Clumsiness (HP:0002312)2.07142521
62Anomalous pulmonary venous return (HP:0010772)2.05937352
63Male pseudohermaphroditism (HP:0000037)2.04855374
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.04576463
65Gait imbalance (HP:0002141)2.01681617
66Aplasia/Hypoplasia of the ulna (HP:0006495)1.99258425
67Aplasia/Hypoplasia of the patella (HP:0006498)1.99239599
68Small hand (HP:0200055)1.98594176
69Concave nail (HP:0001598)1.97901005
70Abnormality of the proximal phalanges of the hand (HP:0009834)1.96989132
71Patellar aplasia (HP:0006443)1.96220509
72Metabolic alkalosis (HP:0200114)1.89100582
73Abnormality of the right ventricle (HP:0001707)1.88683950
74Myokymia (HP:0002411)1.88647005
75Abnormality of the axillary hair (HP:0100134)1.88189704
76Abnormality of secondary sexual hair (HP:0009888)1.88189704
77Enlarged kidneys (HP:0000105)1.88014733
78Ectopic kidney (HP:0000086)1.87296301
79Hyperphosphatemia (HP:0002905)1.85743229
80Asplenia (HP:0001746)1.84364077
81Absent thumb (HP:0009777)1.84032398
82Congenital primary aphakia (HP:0007707)1.83895415
83Polyphagia (HP:0002591)1.81871135
84Abnormality of cells of the erythroid lineage (HP:0012130)1.81104532
85Abnormality of the pulmonary veins (HP:0011718)1.78161133
86Incomplete penetrance (HP:0003829)1.78013771
87Nephrogenic diabetes insipidus (HP:0009806)1.77695907
88Congenital stationary night blindness (HP:0007642)1.77651269
89Abnormality of DNA repair (HP:0003254)1.77118013
90Symphalangism affecting the phalanges of the hand (HP:0009773)1.76855987
91Aplasia/hypoplasia of the uterus (HP:0008684)1.75990385
92Aplasia involving bones of the upper limbs (HP:0009823)1.75918419
93Aplasia of the phalanges of the hand (HP:0009802)1.75918419
94Aplasia involving bones of the extremities (HP:0009825)1.75918419
95Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75554914
96Sclerocornea (HP:0000647)1.75302459
97Abolished electroretinogram (ERG) (HP:0000550)1.75261913
98Abnormal respiratory epithelium morphology (HP:0012253)1.74645673
99Abnormal respiratory motile cilium morphology (HP:0005938)1.74645673
100Specific learning disability (HP:0001328)1.74308899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.13739228
2WNK43.36019566
3TLK13.18864978
4PNCK2.95716813
5EPHB22.37536452
6FGFR21.96624717
7STK161.96192636
8CASK1.95729633
9RPS6KA21.85824376
10ADRBK21.78943873
11SIK21.78762141
12SGK2231.73258766
13SGK4941.73258766
14MAP3K131.73065690
15SGK21.72507864
16ACVR1B1.68707361
17PINK11.67898079
18NTRK21.67791488
19GRK11.63960165
20MAP3K111.60316892
21MAP2K71.58445315
22STK391.55774132
23MAPK151.54807254
24MAP3K41.53936777
25NTRK31.49702405
26DYRK21.48763117
27CAMKK21.48022100
28BMPR1B1.44374424
29TAOK31.35389060
30MAP3K91.33736009
31INSRR1.31850932
32TYRO31.28765521
33RPS6KA61.28569300
34DYRK31.27681248
35PRKCG1.26749745
36MAPK131.22185602
37CAMK1G1.19273977
38WNK11.16046535
39PRKD31.14893092
40STK111.14313408
41MARK11.12729327
42SGK11.12428098
43ZAK1.11599636
44RPS6KC11.08896001
45RPS6KL11.08896001
46STK241.08632622
47BCKDK1.02038547
48CAMKK10.98495226
49ADRBK10.96091017
50TIE10.94934752
51MAP2K40.93909489
52ERBB20.93029128
53SGK30.91927155
54ABL20.88955339
55TAF10.87661545
56GRK70.87651736
57PAK30.84910378
58PIK3CA0.80092523
59MINK10.78352370
60CAMK1D0.78229508
61DMPK0.75344100
62AURKA0.75113469
63NEK20.74439651
64PRKACA0.73601300
65PRKCZ0.70211068
66PLK20.69376559
67PRKD20.64492789
68CDK190.62021513
69MARK20.61402864
70PRKCQ0.59587884
71NUAK10.58384272
72WNK30.58013105
73CAMK10.57285067
74CDK50.56086574
75MAPK40.53516993
76PRKACG0.50540306
77PKN10.49775190
78PLK10.48777410
79TGFBR10.48319057
80PRKCE0.46363177
81TNIK0.44770487
82OXSR10.44610440
83MAP3K70.43185099
84CSNK1G20.41293056
85CHUK0.40509054
86DYRK1A0.39931831
87CSNK1A10.38972515
88BRAF0.38928167
89IKBKB0.38711589
90ILK0.38625803
91EPHA40.38454705
92PLK40.38299019
93PHKG20.38147737
94PHKG10.38147737
95AKT30.37346390
96PRKCA0.35574444
97AKT10.35431700
98MKNK20.35422464
99RPS6KA10.34928294
100MAPKAPK50.34416797

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.82066097
2Nicotine addiction_Homo sapiens_hsa050332.67399964
3Oxidative phosphorylation_Homo sapiens_hsa001902.67140486
4Ribosome_Homo sapiens_hsa030102.57101764
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42219283
6Cardiac muscle contraction_Homo sapiens_hsa042602.40921405
7Phototransduction_Homo sapiens_hsa047442.06805287
8Sulfur metabolism_Homo sapiens_hsa009202.03954287
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01911644
10Parkinsons disease_Homo sapiens_hsa050121.95672314
11Glutamatergic synapse_Homo sapiens_hsa047241.82132519
12Serotonergic synapse_Homo sapiens_hsa047261.80532238
13Tryptophan metabolism_Homo sapiens_hsa003801.80214557
14Morphine addiction_Homo sapiens_hsa050321.77937626
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76088682
16Cholinergic synapse_Homo sapiens_hsa047251.71777789
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69510669
18Sulfur relay system_Homo sapiens_hsa041221.68749790
19Type II diabetes mellitus_Homo sapiens_hsa049301.67647073
20Linoleic acid metabolism_Homo sapiens_hsa005911.65028961
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63133213
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60764124
23Alzheimers disease_Homo sapiens_hsa050101.58278944
24Retinol metabolism_Homo sapiens_hsa008301.51799934
25Vitamin digestion and absorption_Homo sapiens_hsa049771.51078136
26Huntingtons disease_Homo sapiens_hsa050161.44423155
27Basal cell carcinoma_Homo sapiens_hsa052171.44205556
28GABAergic synapse_Homo sapiens_hsa047271.40364665
29Dopaminergic synapse_Homo sapiens_hsa047281.37547864
30Circadian entrainment_Homo sapiens_hsa047131.36550074
31Axon guidance_Homo sapiens_hsa043601.36009100
32Peroxisome_Homo sapiens_hsa041461.32077742
33Cocaine addiction_Homo sapiens_hsa050301.30397470
34Collecting duct acid secretion_Homo sapiens_hsa049661.23247784
35Fanconi anemia pathway_Homo sapiens_hsa034601.22674917
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19169573
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17934025
38Melanoma_Homo sapiens_hsa052181.13886960
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13595792
40Glycerolipid metabolism_Homo sapiens_hsa005611.12956297
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10548732
42Dorso-ventral axis formation_Homo sapiens_hsa043201.09998044
43Chemical carcinogenesis_Homo sapiens_hsa052041.08400342
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07627059
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.07366591
46Protein export_Homo sapiens_hsa030601.05175004
47Fatty acid biosynthesis_Homo sapiens_hsa000611.03302985
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02879593
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.02674085
50Steroid biosynthesis_Homo sapiens_hsa001001.00644809
51MAPK signaling pathway_Homo sapiens_hsa040100.99054655
52Hedgehog signaling pathway_Homo sapiens_hsa043400.96495311
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94855619
54Insulin secretion_Homo sapiens_hsa049110.93519727
55Basal transcription factors_Homo sapiens_hsa030220.92435759
56Regulation of autophagy_Homo sapiens_hsa041400.91666425
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89218051
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87166271
59Oxytocin signaling pathway_Homo sapiens_hsa049210.86549804
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.86327845
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80956115
62Calcium signaling pathway_Homo sapiens_hsa040200.80906680
63Nitrogen metabolism_Homo sapiens_hsa009100.79951669
64PPAR signaling pathway_Homo sapiens_hsa033200.78983446
65Olfactory transduction_Homo sapiens_hsa047400.77865317
66Hippo signaling pathway_Homo sapiens_hsa043900.77038844
67Ether lipid metabolism_Homo sapiens_hsa005650.76275335
68Notch signaling pathway_Homo sapiens_hsa043300.76218061
69Ras signaling pathway_Homo sapiens_hsa040140.75328919
70cAMP signaling pathway_Homo sapiens_hsa040240.73185770
71Taste transduction_Homo sapiens_hsa047420.71291527
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70738704
73Renin secretion_Homo sapiens_hsa049240.70515059
74RNA degradation_Homo sapiens_hsa030180.70447310
75Homologous recombination_Homo sapiens_hsa034400.69947706
76Fat digestion and absorption_Homo sapiens_hsa049750.66237570
77Alcoholism_Homo sapiens_hsa050340.65273695
78Synaptic vesicle cycle_Homo sapiens_hsa047210.64354796
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64233718
80Amphetamine addiction_Homo sapiens_hsa050310.61004227
81Rap1 signaling pathway_Homo sapiens_hsa040150.58726735
82Long-term depression_Homo sapiens_hsa047300.58463510
83Renin-angiotensin system_Homo sapiens_hsa046140.57814953
84RNA polymerase_Homo sapiens_hsa030200.53950313
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50657108
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50207372
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47522329
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45419467
89Pyruvate metabolism_Homo sapiens_hsa006200.44940150
90Wnt signaling pathway_Homo sapiens_hsa043100.41859014
91Gastric acid secretion_Homo sapiens_hsa049710.41293032
92Selenocompound metabolism_Homo sapiens_hsa004500.38808268
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38271189
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38198178
95Metabolic pathways_Homo sapiens_hsa011000.37714149
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37582745
97Arachidonic acid metabolism_Homo sapiens_hsa005900.36650426
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36079281
99Fatty acid degradation_Homo sapiens_hsa000710.35981584
100Nucleotide excision repair_Homo sapiens_hsa034200.35448026

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