FAM63A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.24202864
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.24202864
3neutrophil activation involved in immune response (GO:0002283)6.05813423
4L-phenylalanine metabolic process (GO:0006558)5.96320587
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.96320587
6cysteine metabolic process (GO:0006534)5.74138957
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.40000294
8aromatic amino acid family catabolic process (GO:0009074)5.26564357
9sulfur amino acid catabolic process (GO:0000098)4.98186799
10leukocyte migration involved in inflammatory response (GO:0002523)4.97501618
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87845017
12negative regulation of cell killing (GO:0031342)4.87845017
13glyoxylate metabolic process (GO:0046487)4.78051103
14bile acid biosynthetic process (GO:0006699)4.64282657
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.56436603
16alpha-linolenic acid metabolic process (GO:0036109)4.55111975
17tryptophan catabolic process (GO:0006569)4.53528386
18indole-containing compound catabolic process (GO:0042436)4.53528386
19indolalkylamine catabolic process (GO:0046218)4.53528386
20neutrophil activation (GO:0042119)4.48495455
21tryptophan metabolic process (GO:0006568)4.47105478
22positive regulation by symbiont of host defense response (GO:0052509)4.44437490
23modulation by symbiont of host defense response (GO:0052031)4.44437490
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44437490
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44437490
26positive regulation by organism of defense response of other organism involved in symbiotic interact4.44437490
27modulation by symbiont of host immune response (GO:0052553)4.44437490
28serine family amino acid catabolic process (GO:0009071)4.40218132
29urea cycle (GO:0000050)4.36423519
30urea metabolic process (GO:0019627)4.36423519
31protein carboxylation (GO:0018214)4.33867256
32peptidyl-glutamic acid carboxylation (GO:0017187)4.33867256
33kynurenine metabolic process (GO:0070189)4.27519026
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23178565
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.23094321
36positive regulation of gamma-delta T cell activation (GO:0046645)4.19009739
37urate metabolic process (GO:0046415)4.17975807
38heme transport (GO:0015886)4.12294661
39nitrogen cycle metabolic process (GO:0071941)4.05833849
40antigen processing and presentation of endogenous antigen (GO:0019883)4.03389906
41aromatic amino acid family metabolic process (GO:0009072)4.03184636
42regulation of protein activation cascade (GO:2000257)4.00704887
43complement activation, alternative pathway (GO:0006957)3.99892369
44bile acid metabolic process (GO:0008206)3.99134370
45serine family amino acid metabolic process (GO:0009069)3.96107444
46detection of other organism (GO:0098543)3.95277826
47positive regulation of mast cell activation (GO:0033005)3.94126417
48negative regulation of fibrinolysis (GO:0051918)3.93374135
49granulocyte activation (GO:0036230)3.89768750
50lysine metabolic process (GO:0006553)3.84332157
51lysine catabolic process (GO:0006554)3.84332157
52amino-acid betaine metabolic process (GO:0006577)3.83277550
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.82991546
54tyrosine metabolic process (GO:0006570)3.80339850
55regulation of complement activation (GO:0030449)3.80324669
56high-density lipoprotein particle remodeling (GO:0034375)3.79642247
57regulation of platelet aggregation (GO:0090330)3.78607227
58homocysteine metabolic process (GO:0050667)3.78483749
59macrophage activation involved in immune response (GO:0002281)3.76291230
60ethanol oxidation (GO:0006069)3.73664493
61aldehyde catabolic process (GO:0046185)3.73163744
62detection of bacterium (GO:0016045)3.72922934
63regulation of triglyceride catabolic process (GO:0010896)3.67793761
64serine family amino acid biosynthetic process (GO:0009070)3.66908552
65microglial cell activation (GO:0001774)3.65701330
66glycine metabolic process (GO:0006544)3.64922706
67regulation of fibrinolysis (GO:0051917)3.61173758
68cellular extravasation (GO:0045123)3.61096493
69alpha-amino acid catabolic process (GO:1901606)3.60962725
70detection of molecule of bacterial origin (GO:0032490)3.60931887
71plasma lipoprotein particle clearance (GO:0034381)3.58534658
72regulation of B cell receptor signaling pathway (GO:0050855)3.56362742
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55030051
74detection of external biotic stimulus (GO:0098581)3.51059355
75triglyceride homeostasis (GO:0070328)3.50284627
76acylglycerol homeostasis (GO:0055090)3.50284627
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47842214
78negative regulation of T-helper cell differentiation (GO:0045623)3.45479508
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45479508
80bile acid and bile salt transport (GO:0015721)3.44720218
81fibrinolysis (GO:0042730)3.44619258
82cellular amino acid catabolic process (GO:0009063)3.44498605
83thrombin receptor signaling pathway (GO:0070493)3.43352180
84drug transmembrane transport (GO:0006855)3.40132702
85positive regulation of triglyceride lipase activity (GO:0061365)3.38098416
86positive regulation of lipoprotein lipase activity (GO:0051006)3.38098416
87coenzyme catabolic process (GO:0009109)3.37987088
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.33997492
89arginine metabolic process (GO:0006525)3.33888000
90regulation of mast cell degranulation (GO:0043304)3.33886387
91cellular modified amino acid catabolic process (GO:0042219)3.33756460
92reverse cholesterol transport (GO:0043691)3.30640466
93response to host immune response (GO:0052572)3.29471262
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29471262
95cellular ketone body metabolic process (GO:0046950)3.29291597
96drug catabolic process (GO:0042737)3.27854038
97regulation of gamma-delta T cell activation (GO:0046643)3.26880152
98negative regulation of sterol transport (GO:0032372)3.25775655
99negative regulation of cholesterol transport (GO:0032375)3.25775655
100indolalkylamine metabolic process (GO:0006586)3.23366340
101cholesterol homeostasis (GO:0042632)3.22118888
102regulation of interferon-beta biosynthetic process (GO:0045357)3.20525053
103fatty acid oxidation (GO:0019395)3.20489952
104myeloid cell activation involved in immune response (GO:0002275)3.19853524
105macrophage activation (GO:0042116)3.19046642
106response to peptidoglycan (GO:0032494)3.18358477
107protein-lipid complex remodeling (GO:0034368)3.17646802
108macromolecular complex remodeling (GO:0034367)3.17646802
109plasma lipoprotein particle remodeling (GO:0034369)3.17646802
110sterol homeostasis (GO:0055092)3.17169093
111fatty acid beta-oxidation (GO:0006635)3.16614704
112ethanol metabolic process (GO:0006067)3.16296370
113carboxylic acid catabolic process (GO:0046395)3.16240591
114organic acid catabolic process (GO:0016054)3.16240591
115regulation of T-helper 2 cell differentiation (GO:0045628)3.16221634
116regulation of mast cell activation (GO:0033003)3.14635717
117drug transport (GO:0015893)3.14629104
118amine catabolic process (GO:0009310)3.13857692
119cellular biogenic amine catabolic process (GO:0042402)3.13857692
120lipid oxidation (GO:0034440)3.13811377
121cofactor catabolic process (GO:0051187)3.13733019
122response to mercury ion (GO:0046689)3.12435748
123regulation of cholesterol homeostasis (GO:2000188)3.11323315
124regulation of platelet activation (GO:0010543)3.10845557
125regulation of mast cell activation involved in immune response (GO:0033006)3.09870643
126cholesterol efflux (GO:0033344)3.09416479
127leukocyte aggregation (GO:0070486)3.08848129
128benzene-containing compound metabolic process (GO:0042537)3.08682564
129regulation of cholesterol esterification (GO:0010872)3.07354067
130regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06816245
131primary alcohol catabolic process (GO:0034310)3.05034297
132fatty acid catabolic process (GO:0009062)3.04980576
133sulfur amino acid metabolic process (GO:0000096)3.04402628
134phospholipid efflux (GO:0033700)3.04142542
135positive regulation of cellular amide metabolic process (GO:0034250)3.04026572
136negative regulation of erythrocyte differentiation (GO:0045647)3.03373849
137acetyl-CoA metabolic process (GO:0006084)3.03233992
138regulation of gamma-delta T cell differentiation (GO:0045586)3.02572288
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01218928
140response to host (GO:0075136)3.01218928
141response to host defenses (GO:0052200)3.01218928
142response to interleukin-15 (GO:0070672)2.99978900
143leukocyte degranulation (GO:0043299)2.99258586
144very long-chain fatty acid metabolic process (GO:0000038)2.98579642
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98531592
146short-chain fatty acid metabolic process (GO:0046459)2.97766451
147branched-chain amino acid catabolic process (GO:0009083)2.96838002
148detection of biotic stimulus (GO:0009595)2.96143147
149regulation of cholesterol metabolic process (GO:0090181)2.95628858
150pantothenate metabolic process (GO:0015939)2.95591134
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94381807
152negative regulation of leukocyte mediated immunity (GO:0002704)2.93837548
153regulation of leukocyte degranulation (GO:0043300)2.93712474
154monocarboxylic acid catabolic process (GO:0072329)2.93412323
155negative regulation of glycoprotein biosynthetic process (GO:0010561)2.93059722
156response to nitrosative stress (GO:0051409)2.92460378
157regulation of bile acid biosynthetic process (GO:0070857)2.91562694
158cellular glucuronidation (GO:0052695)2.90941357
159actin filament polymerization (GO:0030041)2.90343256
160intestinal cholesterol absorption (GO:0030299)2.88914810
161regulation of regulatory T cell differentiation (GO:0045589)2.88689626
162blood coagulation, intrinsic pathway (GO:0007597)2.88075930
163ketone body metabolic process (GO:1902224)2.86646733
164G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.85997116
165respiratory burst (GO:0045730)2.85307364
166neutrophil mediated immunity (GO:0002446)2.84397702
167antigen processing and presentation via MHC class Ib (GO:0002475)2.84235085
168dendritic cell chemotaxis (GO:0002407)2.83304300
169dendritic cell migration (GO:0036336)2.79687936
170positive regulation of granulocyte differentiation (GO:0030854)2.78990856
171megakaryocyte development (GO:0035855)2.76395314
172positive regulation of mast cell degranulation (GO:0043306)2.76254923
173positive regulation of mast cell activation involved in immune response (GO:0033008)2.76254923
174adenosine receptor signaling pathway (GO:0001973)2.70075412
175production of molecular mediator involved in inflammatory response (GO:0002532)2.66447704
176regulation of regulated secretory pathway (GO:1903305)2.64245706
177negative regulation of interleukin-12 production (GO:0032695)2.62692984
178positive regulation of receptor recycling (GO:0001921)2.62613270
179cellular response to interleukin-15 (GO:0071350)2.60886798
180negative regulation of alpha-beta T cell activation (GO:0046636)2.59634420
181immunoglobulin mediated immune response (GO:0016064)2.59556803
182positive regulation of toll-like receptor signaling pathway (GO:0034123)2.58891707
183positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57143727
184B cell receptor signaling pathway (GO:0050853)2.52628468
185regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51987971
186regulation of natural killer cell mediated immunity (GO:0002715)2.51987971
187G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.50909086
188regulation of amyloid precursor protein catabolic process (GO:1902991)2.50290704
189regulation of memory T cell differentiation (GO:0043380)2.49841820
190angiogenesis involved in wound healing (GO:0060055)2.48225769
191negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.48198968
192negative regulation of T cell mediated immunity (GO:0002710)2.47967051
193germinal center formation (GO:0002467)2.45722927
194lipoxygenase pathway (GO:0019372)2.44581366
195activated T cell proliferation (GO:0050798)2.42618711
196platelet aggregation (GO:0070527)2.42546375
197positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37565479
198positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.36223024
199positive regulation of regulated secretory pathway (GO:1903307)2.34676474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.19233040
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.69458184
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.04832241
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.81538404
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.29906124
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.81680085
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.77614479
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.76439737
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36264510
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13944462
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95974505
12SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.56312207
13SPI1_23127762_ChIP-Seq_K562_Human2.54742348
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.45603119
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31988003
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31569182
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29946722
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23221123
19RUNX_20019798_ChIP-Seq_JUKART_Human2.14408221
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.06879327
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06098718
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01157653
23GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.00269770
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93369288
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90800539
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85959880
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.84012318
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83635385
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75181340
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74145767
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.73896718
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67685693
33VDR_24763502_ChIP-Seq_THP-1_Human1.66403040
34* SPI1_23547873_ChIP-Seq_NB4_Human1.63517085
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61548640
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59599580
37GATA1_22025678_ChIP-Seq_K562_Human1.59402570
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.50755235
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49788441
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49343955
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47459369
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.41077594
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40405011
44* UTX_26944678_Chip-Seq_JUKART_Human1.39800231
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.39540087
46MAF_26560356_Chip-Seq_TH1_Human1.39414514
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.39204148
48MYB_26560356_Chip-Seq_TH2_Human1.37675304
49CLOCK_20551151_ChIP-Seq_293T_Human1.37479504
50VDR_24787735_ChIP-Seq_THP-1_Human1.36166743
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35635002
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35101807
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33813798
54GATA4_25053715_ChIP-Seq_YYC3_Human1.33629912
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31720770
56ZNF263_19887448_ChIP-Seq_K562_Human1.30710548
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29583955
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28006261
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27916139
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26935811
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26901029
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25506116
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25506116
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25506116
65* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24222296
66* GATA3_27048872_Chip-Seq_THYMUS_Human1.23257251
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23250272
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.21155538
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15721173
70MYB_26560356_Chip-Seq_TH1_Human1.14902584
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14786170
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14117252
73GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12157193
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09292442
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09007147
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08642407
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.08323201
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07123794
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05904700
80KDM2B_26808549_Chip-Seq_DND41_Human1.05902417
81* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05505679
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.05250015
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.04742286
84VDR_21846776_ChIP-Seq_THP-1_Human1.03777302
85SCL_19346495_ChIP-Seq_HPC-7_Human1.02399042
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99936283
87GATA3_26560356_Chip-Seq_TH2_Human0.99423470
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99230801
89* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98016264
90PU_27001747_Chip-Seq_BMDM_Mouse0.97867753
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96490240
92AR_21909140_ChIP-Seq_LNCAP_Human0.95930606
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94967201
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92706782
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92336639
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92252535
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92240434
98BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91870459
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91188987
100ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90829527
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90418326
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90272892
103DROSHA_22980978_ChIP-Seq_HELA_Human0.89818154
104SPI1_20517297_ChIP-Seq_HL60_Human0.89748410
105* MAF_26560356_Chip-Seq_TH2_Human0.89549317
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88535272
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87989071
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87146429
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87021218
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86691066
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86604006
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86272267
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85980598
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85922786
115CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85634578
116KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85039113
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84837245
118GATA1_19941826_ChIP-Seq_K562_Human0.84279450
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83879890
120* GATA6_25053715_ChIP-Seq_YYC3_Human0.83718937
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83553622
122BCL6_27268052_Chip-Seq_Bcells_Human0.83520542
123* FOXO3_23340844_ChIP-Seq_DLD1_Human0.83449179
124ATF3_27146783_Chip-Seq_COLON_Human0.83282306
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.82656281
126* LXR_22292898_ChIP-Seq_THP-1_Human0.82601343
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81413024
128* RACK7_27058665_Chip-Seq_MCF-7_Human0.79802701
129IRF8_22096565_ChIP-ChIP_GC-B_Human0.79751196
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79600964
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79480402
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78670965
133SOX2_20726797_ChIP-Seq_SW620_Human0.78650123
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.78022717
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77695580
136* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76516250
137* ELK3_25401928_ChIP-Seq_HUVEC_Human0.75395166
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74631713
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74188697
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.74054852
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73105231
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72996037
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72990217
144GATA2_19941826_ChIP-Seq_K562_Human0.72697515
145HTT_18923047_ChIP-ChIP_STHdh_Human0.72582217
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72518981
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72348489
148JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72210536
149E2F1_18555785_ChIP-Seq_MESCs_Mouse0.72127339
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.72090412
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71456085
152BCOR_27268052_Chip-Seq_Bcells_Human0.71119992
153FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70897904
154* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70793047
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70639964
156* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69484068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.01167261
2MP0005360_urolithiasis5.51203627
3MP0005365_abnormal_bile_salt4.72556846
4MP0005085_abnormal_gallbladder_physiolo4.61069529
5MP0008875_abnormal_xenobiotic_pharmacok3.79604296
6MP0003806_abnormal_nucleotide_metabolis3.75723939
7MP0009840_abnormal_foam_cell3.45719808
8MP0003303_peritoneal_inflammation3.22611417
9MP0001835_abnormal_antigen_presentation2.85333924
10MP0005451_abnormal_body_composition2.81471990
11MP0005083_abnormal_biliary_tract2.79767923
12MP0010329_abnormal_lipoprotein_level2.62854450
13MP0008004_abnormal_stomach_pH2.62312908
14MP0003252_abnormal_bile_duct2.59433071
15MP0005408_hypopigmentation2.56662014
16MP0004510_myositis2.56107955
17MP0001666_abnormal_nutrient_absorption2.49622763
18MP0005332_abnormal_amino_acid2.43721328
19MP0003195_calcinosis2.37610376
20MP0003191_abnormal_cellular_cholesterol2.33122996
21MP0003828_pulmonary_edema2.13609509
22MP0005000_abnormal_immune_tolerance2.11535233
23MP0003300_gastrointestinal_ulcer2.07643205
24MP0005671_abnormal_response_to2.07150207
25MP0002138_abnormal_hepatobiliary_system2.04568794
26MP0001800_abnormal_humoral_immune2.02801317
27MP0001790_abnormal_immune_system1.95798853
28MP0005387_immune_system_phenotype1.95798853
29MP0002723_abnormal_immune_serum1.90939873
30MP0003172_abnormal_lysosome_physiology1.87833705
31MP0003186_abnormal_redox_activity1.85871342
32MP0000609_abnormal_liver_physiology1.83530853
33MP0003656_abnormal_erythrocyte_physiolo1.82348851
34MP0004019_abnormal_vitamin_homeostasis1.80706718
35MP0002420_abnormal_adaptive_immunity1.77978752
36MP0000685_abnormal_immune_system1.77876526
37MP0001819_abnormal_immune_cell1.75703904
38MP0002118_abnormal_lipid_homeostasis1.75679749
39MP0002452_abnormal_antigen_presenting1.74851643
40MP0005058_abnormal_lysosome_morphology1.69885965
41MP0003718_maternal_effect1.66618282
42MP0003866_abnormal_defecation1.64776141
43MP0003868_abnormal_feces_composition1.63642081
44MP0002148_abnormal_hypersensitivity_rea1.63567330
45MP0010155_abnormal_intestine_physiology1.63294719
46MP0003183_abnormal_peptide_metabolism1.61354504
47MP0004130_abnormal_muscle_cell1.56543295
48MP0005319_abnormal_enzyme/_coenzyme1.55619482
49MP0009643_abnormal_urine_homeostasis1.55547241
50MP0009697_abnormal_copulation1.46588264
51MP0002398_abnormal_bone_marrow1.45559880
52MP0001851_eye_inflammation1.44381584
53MP0003724_increased_susceptibility_to1.43195701
54MP0003436_decreased_susceptibility_to1.42981229
55MP0004883_abnormal_blood_vessel1.42282671
56MP0000716_abnormal_immune_system1.32073948
57MP0003763_abnormal_thymus_physiology1.31896568
58MP0010368_abnormal_lymphatic_system1.31010298
59MP0002405_respiratory_system_inflammati1.29292656
60MP0003045_fibrosis1.28977649
61MP0009764_decreased_sensitivity_to1.26677689
62MP0001764_abnormal_homeostasis1.25862948
63MP0008260_abnormal_autophagy1.24423791
64MP0003075_altered_response_to1.21345121
65MP0004084_abnormal_cardiac_muscle1.19979673
66MP0005636_abnormal_mineral_homeostasis1.19780116
67MP0004484_altered_response_of1.18410890
68MP0000598_abnormal_liver_morphology1.17820897
69MP0000689_abnormal_spleen_morphology1.16572980
70MP0005584_abnormal_enzyme/coenzyme_acti1.11162601
71MP0002998_abnormal_bone_remodeling1.10546340
72MP0002722_abnormal_immune_system1.10195221
73MP0002429_abnormal_blood_cell1.09440290
74MP0000858_altered_metastatic_potential1.08474137
75MP0005647_abnormal_sex_gland1.06427387
76MP0004782_abnormal_surfactant_physiolog1.05297123
77MP0005395_other_phenotype1.04955973
78MP0000465_gastrointestinal_hemorrhage1.04309790
79MP0008469_abnormal_protein_level1.03574325
80MP0005220_abnormal_exocrine_pancreas1.03167735
81MP0009333_abnormal_splenocyte_physiolog1.01372635
82MP0005464_abnormal_platelet_physiology0.98681613
83MP0004036_abnormal_muscle_relaxation0.98160807
84MP0000604_amyloidosis0.95947464
85MP0005310_abnormal_salivary_gland0.95848803
86MP0009763_increased_sensitivity_to0.95481349
87MP0003879_abnormal_hair_cell0.95435063
88MP0001756_abnormal_urination0.95267981
89MP0008874_decreased_physiological_sensi0.93159113
90MP0002098_abnormal_vibrissa_morphology0.92601763
91MP0002132_abnormal_respiratory_system0.91902099
92MP0005164_abnormal_response_to0.91786817
93MP0001765_abnormal_ion_homeostasis0.90818094
94MP0005167_abnormal_blood-brain_barrier0.89625411
95MP0001663_abnormal_digestive_system0.88807159
96MP0009278_abnormal_bone_marrow0.87789888
97MP0003453_abnormal_keratinocyte_physiol0.87650698
98MP0003705_abnormal_hypodermis_morpholog0.87572128
99MP0005670_abnormal_white_adipose0.87419734
100MP0005023_abnormal_wound_healing0.87000870
101MP0000703_abnormal_thymus_morphology0.86806116
102MP0000230_abnormal_systemic_arterial0.86271852
103MP0005535_abnormal_body_temperature0.85652239
104MP0003011_delayed_dark_adaptation0.85265387
105MP0000015_abnormal_ear_pigmentation0.84805043
106MP0004147_increased_porphyrin_level0.84720785
107MP0002136_abnormal_kidney_physiology0.82736263
108MP0005248_abnormal_Harderian_gland0.81784909
109MP0004381_abnormal_hair_follicle0.79269067
110MP0002254_reproductive_system_inflammat0.77916772
111MP0001533_abnormal_skeleton_physiology0.77503709
112MP0002796_impaired_skin_barrier0.77424243
113MP0006082_CNS_inflammation0.75651223
114MP0002419_abnormal_innate_immunity0.74630319
115MP0009642_abnormal_blood_homeostasis0.74505538
116MP0005409_darkened_coat_color0.74170582
117MP0009765_abnormal_xenobiotic_induced0.72525654
118MP0000579_abnormal_nail_morphology0.71358471
119MP0002166_altered_tumor_susceptibility0.68779988
120MP0002693_abnormal_pancreas_physiology0.68636710
121MP0005075_abnormal_melanosome_morpholog0.68377113
122MP0004264_abnormal_extraembryonic_tissu0.68097780
123MP0003690_abnormal_glial_cell0.67762576
124MP0000639_abnormal_adrenal_gland0.67699174
125MP0002396_abnormal_hematopoietic_system0.66619280
126MP0002277_abnormal_respiratory_mucosa0.66418884
127MP0001845_abnormal_inflammatory_respons0.66109918
128MP0002332_abnormal_exercise_endurance0.64058827
129MP0006036_abnormal_mitochondrial_physio0.63950867
130MP0001661_extended_life_span0.63011107
131MP0002295_abnormal_pulmonary_circulatio0.62679817
132MP0005390_skeleton_phenotype0.62199169
133MP0005666_abnormal_adipose_tissue0.61878384
134MP0002078_abnormal_glucose_homeostasis0.61835243
135MP0005084_abnormal_gallbladder_morpholo0.60712253
136MP0000462_abnormal_digestive_system0.60225214
137MP0009785_altered_susceptibility_to0.58450914
138MP0003950_abnormal_plasma_membrane0.57970492
139MP0005025_abnormal_response_to0.57105320
140MP0000371_diluted_coat_color0.56429217
141MP0003566_abnormal_cell_adhesion0.56034146
142MP0000343_altered_response_to0.55044611
143MP0008873_increased_physiological_sensi0.54237138
144MP0004947_skin_inflammation0.53927832
145MP0005376_homeostasis/metabolism_phenot0.52071859
146MP0002060_abnormal_skin_morphology0.52020533
147MP0000249_abnormal_blood_vessel0.51741393
148MP0000647_abnormal_sebaceous_gland0.51105147
149MP0004185_abnormal_adipocyte_glucose0.50934960
150MP0000920_abnormal_myelination0.50910697
151MP0003638_abnormal_response/metabolism_0.50323474
152MP0003699_abnormal_female_reproductive0.49844845
153MP0000377_abnormal_hair_follicle0.49776011
154MP0009931_abnormal_skin_appearance0.49216241
155MP0005397_hematopoietic_system_phenotyp0.48914571
156MP0001545_abnormal_hematopoietic_system0.48914571
157MP0002168_other_aberrant_phenotype0.47376961
158MP0005166_decreased_susceptibility_to0.47122593
159MP0005501_abnormal_skin_physiology0.46890444
160MP0003329_amyloid_beta_deposits0.46558368

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.66542355
2Intrahepatic cholestasis (HP:0001406)6.21166930
3Petechiae (HP:0000967)6.20557607
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.19668102
5Abnormal platelet volume (HP:0011876)5.75401438
6Deep venous thrombosis (HP:0002625)5.71743858
7Increased mean platelet volume (HP:0011877)5.42198742
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.36264468
9Xanthomatosis (HP:0000991)5.18930596
10Eczematoid dermatitis (HP:0000976)5.16680760
11Hyperlipoproteinemia (HP:0010980)4.61730116
12Hypobetalipoproteinemia (HP:0003563)4.60475170
13Recurrent abscess formation (HP:0002722)4.37429704
14Prolonged partial thromboplastin time (HP:0003645)4.22201831
15Myositis (HP:0100614)4.20438004
16Spontaneous hematomas (HP:0007420)4.12997235
17Stomatitis (HP:0010280)4.04936581
18Orchitis (HP:0100796)4.01748390
19Hyperglycinuria (HP:0003108)3.82746606
20Hyperammonemia (HP:0001987)3.80595047
21Complement deficiency (HP:0004431)3.80156711
22Optic neuritis (HP:0100653)3.74668844
23Retrobulbar optic neuritis (HP:0100654)3.74668844
24Joint hemorrhage (HP:0005261)3.72724148
25Abnormality of fatty-acid metabolism (HP:0004359)3.70881279
26Fat malabsorption (HP:0002630)3.69724075
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.68986121
28Hyperglycinemia (HP:0002154)3.68315108
29Abnormality of serine family amino acid metabolism (HP:0010894)3.60781999
30Abnormality of glycine metabolism (HP:0010895)3.60781999
31Abnormality of the common coagulation pathway (HP:0010990)3.55258171
32Hypochromic microcytic anemia (HP:0004840)3.50202903
33Hypolipoproteinemia (HP:0010981)3.47144077
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39454615
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38657236
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36265973
37Abnormality of methionine metabolism (HP:0010901)3.31369888
38Ketosis (HP:0001946)3.26893324
39Gastrointestinal infarctions (HP:0005244)3.25009801
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23973118
41Elevated erythrocyte sedimentation rate (HP:0003565)3.20068268
42Abnormality of the intrinsic pathway (HP:0010989)3.19615457
43Abnormal platelet function (HP:0011869)3.18986669
44Impaired platelet aggregation (HP:0003540)3.18986669
45Steatorrhea (HP:0002570)3.18336566
46Gout (HP:0001997)3.16450792
47Chronic obstructive pulmonary disease (HP:0006510)3.15753961
48Obstructive lung disease (HP:0006536)3.15753961
49Generalized aminoaciduria (HP:0002909)3.12763817
50Hypoglycemic coma (HP:0001325)3.10351689
51Episodic fever (HP:0001954)3.03918800
52Encephalitis (HP:0002383)3.00749337
53Hypoalphalipoproteinemia (HP:0003233)2.99375179
54Epidermoid cyst (HP:0200040)2.97897862
55Abnormality of purine metabolism (HP:0004352)2.97662122
56Abnormality of nucleobase metabolism (HP:0010932)2.93752155
57Hypercholesterolemia (HP:0003124)2.89322550
58Chest pain (HP:0100749)2.86118524
59Abnormality of pyrimidine metabolism (HP:0004353)2.85932221
60Arterial thrombosis (HP:0004420)2.85043601
61Recurrent fungal infections (HP:0002841)2.75029059
62Esophageal varix (HP:0002040)2.73301767
63Abnormality of complement system (HP:0005339)2.72705052
64Myocardial infarction (HP:0001658)2.72378897
65Increased IgE level (HP:0003212)2.70715493
66Recurrent skin infections (HP:0001581)2.69227751
67Keratoconjunctivitis sicca (HP:0001097)2.66583191
68Hypochromic anemia (HP:0001931)2.66429061
69Gingivitis (HP:0000230)2.65332724
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64882827
71Dicarboxylic aciduria (HP:0003215)2.64882827
72Recurrent gram-negative bacterial infections (HP:0005420)2.61298436
73Bruising susceptibility (HP:0000978)2.60615826
74Vascular calcification (HP:0004934)2.59880594
75Conjugated hyperbilirubinemia (HP:0002908)2.58655220
76Meningitis (HP:0001287)2.58151213
77Malnutrition (HP:0004395)2.57390459
78Spastic paraparesis (HP:0002313)2.53989775
79Metabolic acidosis (HP:0001942)2.53770135
80Spastic diplegia (HP:0001264)2.52865236
81Ventricular fibrillation (HP:0001663)2.51037857
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.49378830
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.48791814
84Keratoconjunctivitis (HP:0001096)2.48244118
85Pulmonary embolism (HP:0002204)2.48040956
86Abnormality of serum amino acid levels (HP:0003112)2.47883692
87Urticaria (HP:0001025)2.46870792
88Abnormality of iron homeostasis (HP:0011031)2.46334340
89Systemic lupus erythematosus (HP:0002725)2.45469568
90Inflammation of the large intestine (HP:0002037)2.43492543
91Abnormality of transition element cation homeostasis (HP:0011030)2.42437760
92Hyperbilirubinemia (HP:0002904)2.41619446
93Increased serum ferritin (HP:0003281)2.39983078
94Menorrhagia (HP:0000132)2.39963302
95Vasculitis (HP:0002633)2.38819814
96Lethargy (HP:0001254)2.38628663
97Gingival bleeding (HP:0000225)2.38337466
98Vacuolated lymphocytes (HP:0001922)2.34160001
99Paraparesis (HP:0002385)2.33669005
100Nausea (HP:0002018)2.32185878
101Microcytic anemia (HP:0001935)2.29456138
102Mediastinal lymphadenopathy (HP:0100721)2.28790398
103Gastrointestinal inflammation (HP:0004386)2.28529188
104Delayed CNS myelination (HP:0002188)2.25554728
105Joint swelling (HP:0001386)2.24255174
106Cardiovascular calcification (HP:0011915)2.23003677
107Peritonitis (HP:0002586)2.22350048
108Vertigo (HP:0002321)2.22232469
109Poikilocytosis (HP:0004447)2.21717215
110Irritability (HP:0000737)2.19718986
111Hepatocellular carcinoma (HP:0001402)2.18212704
112Pancreatitis (HP:0001733)2.17374789
113Polycythemia (HP:0001901)2.17069890
114Axonal loss (HP:0003447)2.16475891
115Anorexia (HP:0002039)2.14742566
116Spontaneous abortion (HP:0005268)2.14394625
117Recurrent cutaneous fungal infections (HP:0011370)2.13447671
118Chronic mucocutaneous candidiasis (HP:0002728)2.13447671
119Hemorrhage of the eye (HP:0011885)2.13447311
120Abnormality of macrophages (HP:0004311)2.11583065
121Abnormal pupillary function (HP:0007686)2.10951426
122Alkalosis (HP:0001948)2.09667196
123Proximal tubulopathy (HP:0000114)2.08653010
124Increased IgM level (HP:0003496)2.07769354
125Increased purine levels (HP:0004368)2.07684640
126Hyperuricemia (HP:0002149)2.07684640
127Hepatosplenomegaly (HP:0001433)2.05653746
128Testicular neoplasm (HP:0010788)2.05476256
129Ketoacidosis (HP:0001993)2.03394724
130Opisthotonus (HP:0002179)2.02746413
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02051343
132Acanthocytosis (HP:0001927)2.01793804
133Abnormality of urine glucose concentration (HP:0011016)2.01726615
134Glycosuria (HP:0003076)2.01726615
135Leukocytosis (HP:0001974)1.99301434
136Vomiting (HP:0002013)1.98491887
137Hemoptysis (HP:0002105)1.97932201
138Dysostosis multiplex (HP:0000943)1.96956679
139Ileus (HP:0002595)1.96553927
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94431049
141Acute hepatic failure (HP:0006554)1.93139420
142Brushfield spots (HP:0001088)1.89437095
143Abnormal cartilage morphology (HP:0002763)1.87373423
144Glomerulonephritis (HP:0000099)1.86951226
145Cellulitis (HP:0100658)1.86561663
146Acne (HP:0001061)1.85270372
147Abnormal enzyme/coenzyme activity (HP:0012379)1.85204013
148Pulmonary infiltrates (HP:0002113)1.84843527
149Purpura (HP:0000979)1.83416365
150Amyloidosis (HP:0011034)1.82681983
151Increased cerebral lipofuscin (HP:0011813)1.82675798
152T lymphocytopenia (HP:0005403)1.82659657
153Gangrene (HP:0100758)1.82394194
154Hyporeflexia of lower limbs (HP:0002600)1.80557878
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80385699
156Muscle fibrillation (HP:0010546)1.80325808
157Breast hypoplasia (HP:0003187)1.79758768
158Abnormality of the endocardium (HP:0004306)1.78417898
159Rickets (HP:0002748)1.78087404
160Muscle fiber splitting (HP:0003555)1.77053799
161Protuberant abdomen (HP:0001538)1.74852792
162Abnormality of T cell number (HP:0011839)1.73095822
163Hypertriglyceridemia (HP:0002155)1.72741490
164Thrombophlebitis (HP:0004418)1.72406027
165Hydroxyprolinuria (HP:0003080)1.71864591
166Abnormality of proline metabolism (HP:0010907)1.71864591
167Recurrent bacterial skin infections (HP:0005406)1.70614388
168Pustule (HP:0200039)1.69739510
169Skin nodule (HP:0200036)1.69362042
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.67698718
171Epistaxis (HP:0000421)1.67182810
172Late onset (HP:0003584)1.67032506
173Granulocytopenia (HP:0001913)1.66789826
174Hypergammaglobulinemia (HP:0010702)1.66622359
175Osteomyelitis (HP:0002754)1.66616766
176Difficulty running (HP:0009046)1.65186764
177Increased density of long bones (HP:0006392)1.63306682
178Toxemia of pregnancy (HP:0100603)1.62890838
179Increased CSF protein (HP:0002922)1.62693462
180Congenital sensorineural hearing impairment (HP:0008527)1.61233105
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57706651
182Colitis (HP:0002583)1.55761665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.74964066
2RIPK44.92055367
3BCKDK4.03717086
4ERN12.93472496
5TNK22.58599335
6TAOK32.53321235
7MAP2K32.49342021
8BLK2.44509329
9ACVR1B2.42271675
10ERBB42.37959424
11AKT32.28792186
12GRK62.27523341
13EPHB12.24891076
14MAP4K12.19131451
15BTK2.10788357
16FES2.09789603
17CSK2.07896205
18FGFR41.88767588
19TIE11.88163473
20MAP3K101.77336280
21HCK1.75940301
22EPHA21.73466611
23SYK1.72531250
24FGR1.70789590
25MAP3K61.64716408
26MET1.64544011
27NME21.60470864
28IRAK31.59920502
29BMX1.59710612
30ABL21.57996845
31LATS11.57449680
32PTK2B1.55570083
33MST1R1.55103799
34TEC1.39504767
35EEF2K1.39504336
36PLK41.32229083
37JAK31.30890099
38MUSK1.29211196
39TGFBR11.28081382
40KDR1.26796620
41YES11.26298699
42BRAF1.26241606
43MAPKAPK31.21698459
44MARK21.21690247
45MAP3K11.20232619
46MAP3K111.19695172
47JAK11.19255774
48LYN1.17103961
49SIK31.15646005
50PDK11.12997481
51MAP2K21.12544645
52TBK11.12147395
53TXK1.10545144
54ITK1.10448478
55PDPK11.07354254
56RIPK11.05483197
57EPHA31.05009064
58TTK1.01437844
59MAP3K21.00942188
60MAP3K31.00751797
61MAPKAPK51.00236198
62TYK21.00039159
63MYLK0.99891640
64OXSR10.99798166
65DAPK20.99293448
66STK390.97288942
67STK30.96166624
68PRKD20.96052795
69BMPR20.95545052
70TLK10.94133262
71RPS6KB20.94116529
72TRIB30.93924914
73STK100.92442159
74KSR20.91910212
75PRPF4B0.88146640
76LRRK20.87099878
77IRAK10.86847456
78LCK0.86112066
79FGFR30.85907698
80RET0.84501674
81SIK10.83898984
82SGK20.81749109
83SGK30.81563774
84PTK60.79745081
85TAOK10.79513047
86MAPK110.78075643
87NEK90.77716410
88BUB10.77383409
89FRK0.77357979
90HIPK20.76362955
91MAP3K50.76221433
92STK40.76141671
93DYRK1B0.75041863
94MAP3K70.74111999
95MARK30.73213651
96CSNK1G10.72988440
97MAP3K80.72465598
98DYRK30.72390884
99PIM20.71799423
100PRKD10.70453539
101CSNK1G30.69962719
102MAP2K40.69192724
103PRKG20.68437015
104KIT0.67844505
105FER0.67634044
106PRKAA20.66734663
107FLT30.66585882
108FYN0.66434448
109PIK3CG0.65217476
110PIM10.63140468
111IKBKB0.63045181
112GRK50.62648948
113ARAF0.61905249
114JAK20.61722624
115TESK20.61620661
116MAP2K60.61598899
117BMPR1B0.61285157
118NLK0.59552790
119CDC42BPA0.59049425
120TGFBR20.58810904
121IRAK20.58728753
122STK38L0.56531464
123FGFR20.56231076
124DYRK20.55756399
125STK380.54252786
126TRPM70.52738832
127LATS20.52591359
128PTK20.52030608
129PAK30.51446280
130TAOK20.51148227
131MAP2K10.50802389
132MAPK40.48802204
133SGK2230.48461834
134SGK4940.48461834
135IRAK40.47405464
136PINK10.47273067
137MAPK120.47243570
138MAP3K140.46900577
139GSK3A0.45436434
140BRSK20.45209709
141CSNK1A1L0.45145304
142MATK0.44470378
143STK110.44077637
144PRKAA10.43933264
145PRKCZ0.43897412
146EPHB20.43869176
147ERBB20.43862105
148IKBKE0.42933510
149PRKCQ0.42392811
150MAPK70.42314740
151MST40.42145069
152PBK0.42141211
153ZAP700.42036382
154STK240.41741587
155CSF1R0.41561370
156LMTK20.39864963
157ABL10.39464964
158CDK70.38876823
159PDGFRB0.38364481
160MELK0.38363417
161MOS0.37610956
162PAK40.37286422
163GRK10.36991985
164CDK40.35759622
165PKN20.35646610

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60829981
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86609472
3Platelet activation_Homo sapiens_hsa046112.78200186
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62067975
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43508025
6Arginine biosynthesis_Homo sapiens_hsa002202.38953831
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38273634
8Complement and coagulation cascades_Homo sapiens_hsa046102.35850688
9Nitrogen metabolism_Homo sapiens_hsa009102.32677871
10Osteoclast differentiation_Homo sapiens_hsa043802.29072766
11Fatty acid degradation_Homo sapiens_hsa000712.28864165
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26580556
13Folate biosynthesis_Homo sapiens_hsa007902.17826733
14Tryptophan metabolism_Homo sapiens_hsa003802.17518396
15Histidine metabolism_Homo sapiens_hsa003402.13978465
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.09043895
17Peroxisome_Homo sapiens_hsa041462.07001726
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05919918
19Vitamin B6 metabolism_Homo sapiens_hsa007502.04575764
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98633434
21beta-Alanine metabolism_Homo sapiens_hsa004101.95440489
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92059095
23Caffeine metabolism_Homo sapiens_hsa002321.91293011
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85175546
25Steroid biosynthesis_Homo sapiens_hsa001001.84320396
26B cell receptor signaling pathway_Homo sapiens_hsa046621.76694642
27Chemokine signaling pathway_Homo sapiens_hsa040621.74098440
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71938552
29Butanoate metabolism_Homo sapiens_hsa006501.71485597
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70747815
31Staphylococcus aureus infection_Homo sapiens_hsa051501.68792643
32Propanoate metabolism_Homo sapiens_hsa006401.66944691
33PPAR signaling pathway_Homo sapiens_hsa033201.66805250
34Chemical carcinogenesis_Homo sapiens_hsa052041.66304983
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65721626
36Fatty acid metabolism_Homo sapiens_hsa012121.61484261
37Fatty acid elongation_Homo sapiens_hsa000621.59750529
38Selenocompound metabolism_Homo sapiens_hsa004501.59398412
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.56336321
40Hematopoietic cell lineage_Homo sapiens_hsa046401.55191919
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.54805359
42Tuberculosis_Homo sapiens_hsa051521.52879541
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52331874
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47952829
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45643534
46Vitamin digestion and absorption_Homo sapiens_hsa049771.45246103
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44636396
48Retinol metabolism_Homo sapiens_hsa008301.43025353
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41888763
50Sulfur relay system_Homo sapiens_hsa041221.41665708
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.38115303
52T cell receptor signaling pathway_Homo sapiens_hsa046601.35373245
53Acute myeloid leukemia_Homo sapiens_hsa052211.33388576
54Sulfur metabolism_Homo sapiens_hsa009201.33297473
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30757460
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.25232062
57Fat digestion and absorption_Homo sapiens_hsa049751.25109210
58Arginine and proline metabolism_Homo sapiens_hsa003301.22835295
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21475345
60Glutathione metabolism_Homo sapiens_hsa004801.18175054
61Phagosome_Homo sapiens_hsa041451.17082189
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15871019
63Phenylalanine metabolism_Homo sapiens_hsa003601.14951689
64Endocytosis_Homo sapiens_hsa041441.12165674
65Tyrosine metabolism_Homo sapiens_hsa003501.11856336
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10800700
67Non-small cell lung cancer_Homo sapiens_hsa052231.10312753
68Autoimmune thyroid disease_Homo sapiens_hsa053201.09846841
69Graft-versus-host disease_Homo sapiens_hsa053321.09230225
70Measles_Homo sapiens_hsa051621.08312355
71Pyruvate metabolism_Homo sapiens_hsa006201.07846421
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.07790555
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06401610
74Biosynthesis of amino acids_Homo sapiens_hsa012301.06365060
75Bile secretion_Homo sapiens_hsa049761.06126952
76Allograft rejection_Homo sapiens_hsa053301.05847400
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05653738
78NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05212961
79ABC transporters_Homo sapiens_hsa020101.05024822
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04720206
81Maturity onset diabetes of the young_Homo sapiens_hsa049501.01943300
82Starch and sucrose metabolism_Homo sapiens_hsa005001.01512645
83Phospholipase D signaling pathway_Homo sapiens_hsa040721.00760001
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99420326
85VEGF signaling pathway_Homo sapiens_hsa043700.99147577
86Primary immunodeficiency_Homo sapiens_hsa053400.98989222
87Pentose phosphate pathway_Homo sapiens_hsa000300.98595537
88Toxoplasmosis_Homo sapiens_hsa051450.97047449
89Linoleic acid metabolism_Homo sapiens_hsa005910.95289961
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.95117802
91Carbon metabolism_Homo sapiens_hsa012000.94609912
92Pancreatic secretion_Homo sapiens_hsa049720.93998678
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92687716
94Type I diabetes mellitus_Homo sapiens_hsa049400.90413172
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90063622
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88843893
97Collecting duct acid secretion_Homo sapiens_hsa049660.87387605
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85634529
99Endometrial cancer_Homo sapiens_hsa052130.85221454
100Choline metabolism in cancer_Homo sapiens_hsa052310.85061858
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.84844509
102Renal cell carcinoma_Homo sapiens_hsa052110.84613772
103Glycerolipid metabolism_Homo sapiens_hsa005610.83725973
104Pancreatic cancer_Homo sapiens_hsa052120.81881393
105Renin-angiotensin system_Homo sapiens_hsa046140.79291167
106Influenza A_Homo sapiens_hsa051640.78090652
107Notch signaling pathway_Homo sapiens_hsa043300.76814943
108Inositol phosphate metabolism_Homo sapiens_hsa005620.75942385
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75176926
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.73319532
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.70870520
112Shigellosis_Homo sapiens_hsa051310.70698837
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70379437
114Prolactin signaling pathway_Homo sapiens_hsa049170.67327334
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66731109
116Viral myocarditis_Homo sapiens_hsa054160.66516420
117TNF signaling pathway_Homo sapiens_hsa046680.66467607
118Other glycan degradation_Homo sapiens_hsa005110.65868842
119FoxO signaling pathway_Homo sapiens_hsa040680.65458344
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64793825
121GnRH signaling pathway_Homo sapiens_hsa049120.63729366
122Serotonergic synapse_Homo sapiens_hsa047260.63392103
123Long-term depression_Homo sapiens_hsa047300.62100743
124Rap1 signaling pathway_Homo sapiens_hsa040150.62034576
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.61790909
126Lysine degradation_Homo sapiens_hsa003100.61061068
127Hepatitis B_Homo sapiens_hsa051610.59490413
128Amoebiasis_Homo sapiens_hsa051460.59368213
129Renin secretion_Homo sapiens_hsa049240.58254716
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57381616
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57190123
132Chronic myeloid leukemia_Homo sapiens_hsa052200.57138891
133Type II diabetes mellitus_Homo sapiens_hsa049300.57103662
134Salmonella infection_Homo sapiens_hsa051320.56194000
135Metabolic pathways_Homo sapiens_hsa011000.55068776
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.55044567
137Arachidonic acid metabolism_Homo sapiens_hsa005900.54560436
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54152172
139Insulin signaling pathway_Homo sapiens_hsa049100.53438554
140Dorso-ventral axis formation_Homo sapiens_hsa043200.52536202
141Gap junction_Homo sapiens_hsa045400.52411683
142Ether lipid metabolism_Homo sapiens_hsa005650.51531576
143Lysosome_Homo sapiens_hsa041420.50971323
144Gastric acid secretion_Homo sapiens_hsa049710.50893377
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48947177
146Regulation of autophagy_Homo sapiens_hsa041400.48647267
147mTOR signaling pathway_Homo sapiens_hsa041500.48189248
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46455796
149Mineral absorption_Homo sapiens_hsa049780.44779003
150Fructose and mannose metabolism_Homo sapiens_hsa000510.41825153
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41231630
152Ovarian steroidogenesis_Homo sapiens_hsa049130.40832378
153One carbon pool by folate_Homo sapiens_hsa006700.37817041
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.35586284
155Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34452318
156Galactose metabolism_Homo sapiens_hsa000520.29226921
157Protein export_Homo sapiens_hsa030600.27718931
158Insulin resistance_Homo sapiens_hsa049310.19427535
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.19276906
160Sphingolipid metabolism_Homo sapiens_hsa006000.17976651
161Hepatitis C_Homo sapiens_hsa051600.13202956
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12664205
163African trypanosomiasis_Homo sapiens_hsa051430.10531482
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09634718
165Malaria_Homo sapiens_hsa051440.08599023
166Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.06205460
167Protein digestion and absorption_Homo sapiens_hsa049740.05537943
168Fatty acid biosynthesis_Homo sapiens_hsa000610.04578696
169Pyrimidine metabolism_Homo sapiens_hsa002400.03819307
170AMPK signaling pathway_Homo sapiens_hsa041520.03791110
171Legionellosis_Homo sapiens_hsa051340.02671025
172Pertussis_Homo sapiens_hsa051330.01482564
173Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.01105125
174Leishmaniasis_Homo sapiens_hsa05140-0.0214562

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