

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 6.14198353 |
| 2 | mitotic sister chromatid segregation (GO:0000070) | 5.83735955 |
| 3 | sister chromatid segregation (GO:0000819) | 5.64597269 |
| 4 | kinetochore organization (GO:0051383) | 5.45976426 |
| 5 | protein localization to chromosome, centromeric region (GO:0071459) | 5.44811268 |
| 6 | DNA unwinding involved in DNA replication (GO:0006268) | 5.43991559 |
| 7 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 5.27616880 |
| 8 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.19736460 |
| 9 | mitotic metaphase plate congression (GO:0007080) | 5.19235076 |
| 10 | mitotic chromosome condensation (GO:0007076) | 4.87338102 |
| 11 | kinetochore assembly (GO:0051382) | 4.84600951 |
| 12 | regulation of spindle organization (GO:0090224) | 4.84045771 |
| 13 | metaphase plate congression (GO:0051310) | 4.67716513 |
| 14 | establishment of chromosome localization (GO:0051303) | 4.60571856 |
| 15 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.40679589 |
| 16 | CENP-A containing nucleosome assembly (GO:0034080) | 4.37181046 |
| 17 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.34560218 |
| 18 | DNA topological change (GO:0006265) | 4.31938793 |
| 19 | chromatin remodeling at centromere (GO:0031055) | 4.21565252 |
| 20 | regulation of mitotic spindle organization (GO:0060236) | 4.21463285 |
| 21 | mitotic nuclear envelope disassembly (GO:0007077) | 4.21453361 |
| 22 | spindle checkpoint (GO:0031577) | 4.15544777 |
| 23 | DNA strand elongation (GO:0022616) | 4.12376694 |
| 24 | regulation of chromosome segregation (GO:0051983) | 4.04533140 |
| 25 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.04396846 |
| 26 | spindle assembly checkpoint (GO:0071173) | 4.02645168 |
| 27 | negative regulation of chromosome segregation (GO:0051985) | 3.99481994 |
| 28 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.96057789 |
| 29 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.96057789 |
| 30 | negative regulation of sister chromatid segregation (GO:0033046) | 3.96057789 |
| 31 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.96057789 |
| 32 | mitotic spindle assembly checkpoint (GO:0007094) | 3.95439800 |
| 33 | nuclear envelope disassembly (GO:0051081) | 3.90627554 |
| 34 | membrane disassembly (GO:0030397) | 3.90627554 |
| 35 | DNA replication-independent nucleosome organization (GO:0034724) | 3.90133251 |
| 36 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.90133251 |
| 37 | L-serine metabolic process (GO:0006563) | 3.83626799 |
| 38 | protein localization to chromosome (GO:0034502) | 3.83545724 |
| 39 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.82653057 |
| 40 | positive regulation of chromosome segregation (GO:0051984) | 3.82650769 |
| 41 | mitotic recombination (GO:0006312) | 3.82504092 |
| 42 | mitotic spindle checkpoint (GO:0071174) | 3.82172158 |
| 43 | DNA replication initiation (GO:0006270) | 3.78920758 |
| 44 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.78449252 |
| 45 | chromosome segregation (GO:0007059) | 3.74603468 |
| 46 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.71453689 |
| 47 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.71453689 |
| 48 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.71453689 |
| 49 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.68491245 |
| 50 | establishment of viral latency (GO:0019043) | 3.68406197 |
| 51 | ribosomal small subunit assembly (GO:0000028) | 3.66710635 |
| 52 | telomere maintenance via recombination (GO:0000722) | 3.63678908 |
| 53 | regulation of sister chromatid segregation (GO:0033045) | 3.62148436 |
| 54 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.62148436 |
| 55 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.62148436 |
| 56 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.57019537 |
| 57 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.57019537 |
| 58 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.56640243 |
| 59 | chromosome condensation (GO:0030261) | 3.56101269 |
| 60 | histone exchange (GO:0043486) | 3.54648783 |
| 61 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.52665631 |
| 62 | meiotic chromosome segregation (GO:0045132) | 3.52190970 |
| 63 | viral transcription (GO:0019083) | 3.51669215 |
| 64 | histone-serine phosphorylation (GO:0035404) | 3.49457282 |
| 65 | translational termination (GO:0006415) | 3.42930808 |
| 66 | nuclear pore organization (GO:0006999) | 3.42851114 |
| 67 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.40811655 |
| 68 | heterochromatin organization (GO:0070828) | 3.36087720 |
| 69 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.27380292 |
| 70 | telomere maintenance via telomere lengthening (GO:0010833) | 3.27205635 |
| 71 | DNA replication checkpoint (GO:0000076) | 3.26318621 |
| 72 | regulation of sister chromatid cohesion (GO:0007063) | 3.25420321 |
| 73 | negative regulation of ligase activity (GO:0051352) | 3.24122217 |
| 74 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.24122217 |
| 75 | chromatin assembly or disassembly (GO:0006333) | 3.23728181 |
| 76 | protein K6-linked ubiquitination (GO:0085020) | 3.22915812 |
| 77 | proteasome assembly (GO:0043248) | 3.21121175 |
| 78 | ATP-dependent chromatin remodeling (GO:0043044) | 3.20801018 |
| 79 | chaperone-mediated protein transport (GO:0072321) | 3.19297303 |
| 80 | DNA duplex unwinding (GO:0032508) | 3.18374032 |
| 81 | establishment of mitotic spindle localization (GO:0040001) | 3.18230738 |
| 82 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.18049400 |
| 83 | DNA geometric change (GO:0032392) | 3.17276663 |
| 84 | establishment of integrated proviral latency (GO:0075713) | 3.16603788 |
| 85 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.16531934 |
| 86 | regulation of centrosome cycle (GO:0046605) | 3.16143035 |
| 87 | negative regulation of nuclear division (GO:0051784) | 3.15902725 |
| 88 | translational elongation (GO:0006414) | 3.14709563 |
| 89 | maturation of SSU-rRNA (GO:0030490) | 3.14626611 |
| 90 | microtubule depolymerization (GO:0007019) | 3.14535625 |
| 91 | DNA ligation (GO:0006266) | 3.14500312 |
| 92 | nuclear pore complex assembly (GO:0051292) | 3.14059477 |
| 93 | negative regulation of RNA splicing (GO:0033119) | 3.11960058 |
| 94 | ventricular cardiac muscle cell development (GO:0055015) | 3.11725100 |
| 95 | regulation of exit from mitosis (GO:0007096) | 3.11715737 |
| 96 | negative regulation of mitosis (GO:0045839) | 3.11692094 |
| 97 | protein complex localization (GO:0031503) | 3.11035232 |
| 98 | negative regulation of cell division (GO:0051782) | 3.08730816 |
| 99 | nuclear envelope organization (GO:0006998) | 3.07665293 |
| 100 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.06559982 |
| 101 | DNA conformation change (GO:0071103) | 3.04055966 |
| 102 | formation of translation preinitiation complex (GO:0001731) | 3.03960614 |
| 103 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.03375228 |
| 104 | DNA packaging (GO:0006323) | 3.03127196 |
| 105 | mitotic cell cycle (GO:0000278) | 3.00882150 |
| 106 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.00187977 |
| 107 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.98931543 |
| 108 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.98931543 |
| 109 | DNA strand renaturation (GO:0000733) | 2.98262942 |
| 110 | negative regulation of proteasomal protein catabolic process (GO:1901799) | 2.94794313 |
| 111 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.93762827 |
| 112 | mitotic G2/M transition checkpoint (GO:0044818) | 2.93642712 |
| 113 | translational initiation (GO:0006413) | 2.93314026 |
| 114 | purine nucleobase biosynthetic process (GO:0009113) | 2.91968281 |
| 115 | DNA damage response, detection of DNA damage (GO:0042769) | 2.91179179 |
| 116 | mitotic spindle organization (GO:0007052) | 2.90579732 |
| 117 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.89597959 |
| 118 | IMP biosynthetic process (GO:0006188) | 2.88350774 |
| 119 | ribosomal small subunit biogenesis (GO:0042274) | 2.87304437 |
| 120 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435) | 2.85942126 |
| 121 | mitotic cytokinesis (GO:0000281) | 2.85033847 |
| 122 | spliceosomal complex assembly (GO:0000245) | 2.83283704 |
| 123 | cellular protein complex disassembly (GO:0043624) | 2.82958917 |
| 124 | base-excision repair (GO:0006284) | 2.82808362 |
| 125 | * mitotic nuclear division (GO:0007067) | 2.82494343 |
| 126 | spliceosomal snRNP assembly (GO:0000387) | 2.81596947 |
| 127 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.81078497 |
| 128 | non-recombinational repair (GO:0000726) | 2.81016871 |
| 129 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.81016871 |
| 130 | mitotic sister chromatid cohesion (GO:0007064) | 2.80773800 |
| 131 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.79147261 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.93406098 |
| 2 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 8.03806755 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.61204886 |
| 4 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 4.61048308 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.83734397 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.46664497 |
| 7 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.80654303 |
| 8 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.75668937 |
| 9 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.68539092 |
| 10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.62286227 |
| 11 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.57898858 |
| 12 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.54334759 |
| 13 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.45476158 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.41762067 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.41722584 |
| 16 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.32121313 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.31570373 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.26225376 |
| 19 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.21510103 |
| 20 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.20743272 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.19220121 |
| 22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.12798865 |
| 23 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.02674194 |
| 24 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.98538132 |
| 25 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.92288021 |
| 26 | MYC_22102868_ChIP-Seq_BL_Human | 1.87071242 |
| 27 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.81394680 |
| 28 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.79841913 |
| 29 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.78159247 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.77719413 |
| 31 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.72863527 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.71342985 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.71231461 |
| 34 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.68279121 |
| 35 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.67013001 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.63930893 |
| 37 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.61873320 |
| 38 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.57188274 |
| 39 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.55721017 |
| 40 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.53518715 |
| 41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.51281700 |
| 42 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.50692881 |
| 43 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48659219 |
| 44 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.47874078 |
| 45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.47299065 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.47010424 |
| 47 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.46779834 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.46607685 |
| 49 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.45837306 |
| 50 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45698953 |
| 51 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.44224387 |
| 52 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.43571640 |
| 53 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43008724 |
| 54 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.38722955 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.37795078 |
| 56 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.36161048 |
| 57 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.35422764 |
| 58 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.33167563 |
| 59 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31246428 |
| 60 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28171160 |
| 61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.26730473 |
| 62 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.21963466 |
| 63 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.21374279 |
| 64 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.20564750 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.20303743 |
| 66 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17425361 |
| 67 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.14200255 |
| 68 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.13521767 |
| 69 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.12272753 |
| 70 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.11330977 |
| 71 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06783250 |
| 72 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.06361931 |
| 73 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.05384005 |
| 74 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.05115062 |
| 75 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.04686248 |
| 76 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.03114337 |
| 77 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.02139966 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.01909546 |
| 79 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01208466 |
| 80 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.00981398 |
| 81 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.00642804 |
| 82 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.99424026 |
| 83 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.99340560 |
| 84 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99164556 |
| 85 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.97639429 |
| 86 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.95453184 |
| 87 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.95115990 |
| 88 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94739568 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94551181 |
| 90 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.93068670 |
| 91 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.91441863 |
| 92 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.90983678 |
| 93 | EWS_26573619_Chip-Seq_HEK293_Human | 0.90198321 |
| 94 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.89974598 |
| 95 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.88119459 |
| 96 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87364803 |
| 97 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.86612856 |
| 98 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.85692203 |
| 99 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.85458354 |
| 100 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.85458354 |
| 101 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.85458354 |
| 102 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85185540 |
| 103 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.84375698 |
| 104 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.84202765 |
| 105 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.84189443 |
| 106 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84065027 |
| 107 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81875092 |
| 108 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.81675130 |
| 109 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.79655331 |
| 110 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.79194713 |
| 111 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.79124693 |
| 112 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.79095429 |
| 113 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.78829447 |
| 114 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.77525216 |
| 115 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.74605353 |
| 116 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.73935640 |
| 117 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.73225566 |
| 118 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.72789146 |
| 119 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.69823440 |
| 120 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.68851704 |
| 121 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.68540781 |
| 122 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.65273338 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.60738708 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.33785707 |
| 3 | MP0003077_abnormal_cell_cycle | 3.95724964 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.94767552 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.68291688 |
| 6 | MP0010030_abnormal_orbit_morphology | 3.35569583 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.95345172 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.92020781 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.68338050 |
| 10 | MP0008057_abnormal_DNA_replication | 2.59507625 |
| 11 | MP0003123_paternal_imprinting | 2.38503315 |
| 12 | MP0003136_yellow_coat_color | 2.34247957 |
| 13 | MP0001730_embryonic_growth_arrest | 2.24463894 |
| 14 | MP0008058_abnormal_DNA_repair | 2.17263033 |
| 15 | MP0003718_maternal_effect | 2.15719174 |
| 16 | MP0003941_abnormal_skin_development | 2.08155187 |
| 17 | MP0000350_abnormal_cell_proliferation | 2.07534953 |
| 18 | MP0000537_abnormal_urethra_morphology | 1.95943219 |
| 19 | MP0009053_abnormal_anal_canal | 1.92820383 |
| 20 | MP0001697_abnormal_embryo_size | 1.79008348 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 1.76278468 |
| 22 | MP0005380_embryogenesis_phenotype | 1.76278468 |
| 23 | MP0002396_abnormal_hematopoietic_system | 1.75829400 |
| 24 | MP0004808_abnormal_hematopoietic_stem | 1.75468872 |
| 25 | MP0003705_abnormal_hypodermis_morpholog | 1.74444413 |
| 26 | MP0002085_abnormal_embryonic_tissue | 1.73247269 |
| 27 | MP0005076_abnormal_cell_differentiation | 1.72953779 |
| 28 | MP0010352_gastrointestinal_tract_polyps | 1.68650188 |
| 29 | MP0006054_spinal_hemorrhage | 1.62687727 |
| 30 | MP0010307_abnormal_tumor_latency | 1.61543785 |
| 31 | MP0009697_abnormal_copulation | 1.61256731 |
| 32 | MP0003984_embryonic_growth_retardation | 1.60168351 |
| 33 | MP0003121_genomic_imprinting | 1.59132588 |
| 34 | MP0002080_prenatal_lethality | 1.57685761 |
| 35 | MP0002088_abnormal_embryonic_growth/wei | 1.57329779 |
| 36 | MP0004197_abnormal_fetal_growth/weight/ | 1.54171290 |
| 37 | MP0002084_abnormal_developmental_patter | 1.53133878 |
| 38 | MP0008789_abnormal_olfactory_epithelium | 1.51953639 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.47412182 |
| 40 | MP0002086_abnormal_extraembryonic_tissu | 1.40343847 |
| 41 | MP0009278_abnormal_bone_marrow | 1.38660995 |
| 42 | MP0002233_abnormal_nose_morphology | 1.34049156 |
| 43 | MP0000049_abnormal_middle_ear | 1.33456047 |
| 44 | MP0001293_anophthalmia | 1.28467153 |
| 45 | MP0003937_abnormal_limbs/digits/tail_de | 1.28405128 |
| 46 | MP0000490_abnormal_crypts_of | 1.27309529 |
| 47 | MP0001529_abnormal_vocalization | 1.26769764 |
| 48 | MP0002932_abnormal_joint_morphology | 1.25862538 |
| 49 | MP0002282_abnormal_trachea_morphology | 1.25109004 |
| 50 | MP0000313_abnormal_cell_death | 1.24555834 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.24490542 |
| 52 | MP0003122_maternal_imprinting | 1.24397832 |
| 53 | MP0003115_abnormal_respiratory_system | 1.23942377 |
| 54 | MP0002111_abnormal_tail_morphology | 1.22431037 |
| 55 | MP0003385_abnormal_body_wall | 1.22270763 |
| 56 | MP0000428_abnormal_craniofacial_morphol | 1.21079412 |
| 57 | MP0003942_abnormal_urinary_system | 1.18198459 |
| 58 | MP0002019_abnormal_tumor_incidence | 1.15984322 |
| 59 | MP0000733_abnormal_muscle_development | 1.13954033 |
| 60 | MP0003786_premature_aging | 1.11703937 |
| 61 | MP0004133_heterotaxia | 1.08968091 |
| 62 | MP0005394_taste/olfaction_phenotype | 1.08516391 |
| 63 | MP0005499_abnormal_olfactory_system | 1.08516391 |
| 64 | MP0000372_irregular_coat_pigmentation | 1.07511703 |
| 65 | MP0001346_abnormal_lacrimal_gland | 1.07061222 |
| 66 | MP0002249_abnormal_larynx_morphology | 1.05691154 |
| 67 | MP0009672_abnormal_birth_weight | 1.05175318 |
| 68 | MP0005023_abnormal_wound_healing | 1.05130785 |
| 69 | MP0003119_abnormal_digestive_system | 1.05102794 |
| 70 | MP0000579_abnormal_nail_morphology | 1.04738968 |
| 71 | MP0003315_abnormal_perineum_morphology | 1.04413207 |
| 72 | MP0006072_abnormal_retinal_apoptosis | 1.03520393 |
| 73 | MP0002938_white_spotting | 1.01468987 |
| 74 | MP0000703_abnormal_thymus_morphology | 1.00777231 |
| 75 | MP0003186_abnormal_redox_activity | 1.00363197 |
| 76 | MP0003935_abnormal_craniofacial_develop | 0.98515766 |
| 77 | MP0001915_intracranial_hemorrhage | 0.96433161 |
| 78 | MP0001299_abnormal_eye_distance/ | 0.95222866 |
| 79 | MP0000566_synostosis | 0.92661355 |
| 80 | MP0003283_abnormal_digestive_organ | 0.91633257 |
| 81 | MP0001929_abnormal_gametogenesis | 0.90590648 |
| 82 | MP0006035_abnormal_mitochondrial_morpho | 0.89741168 |
| 83 | MP0008877_abnormal_DNA_methylation | 0.88907195 |
| 84 | MP0001145_abnormal_male_reproductive | 0.88544837 |
| 85 | MP0002092_abnormal_eye_morphology | 0.87956936 |
| 86 | MP0005623_abnormal_meninges_morphology | 0.86966973 |
| 87 | MP0002254_reproductive_system_inflammat | 0.86733611 |
| 88 | MP0001188_hyperpigmentation | 0.86492399 |
| 89 | MP0002697_abnormal_eye_size | 0.86249840 |
| 90 | MP0002925_abnormal_cardiovascular_devel | 0.85848437 |
| 91 | MP0003755_abnormal_palate_morphology | 0.84675030 |
| 92 | MP0005391_vision/eye_phenotype | 0.84347935 |
| 93 | MP0000858_altered_metastatic_potential | 0.84123754 |
| 94 | MP0003566_abnormal_cell_adhesion | 0.83943977 |
| 95 | MP0000432_abnormal_head_morphology | 0.83087054 |
| 96 | MP0001849_ear_inflammation | 0.82690457 |
| 97 | MP0002653_abnormal_ependyma_morphology | 0.82226829 |
| 98 | MP0003279_aneurysm | 0.80800477 |
| 99 | MP0001286_abnormal_eye_development | 0.80745902 |
| 100 | MP0000647_abnormal_sebaceous_gland | 0.80662813 |
| 101 | MP0008438_abnormal_cutaneous_collagen | 0.80464628 |
| 102 | MP0000653_abnormal_sex_gland | 0.80088956 |
| 103 | MP0003861_abnormal_nervous_system | 0.80024442 |
| 104 | MP0004233_abnormal_muscle_weight | 0.79662288 |
| 105 | MP0002116_abnormal_craniofacial_bone | 0.78241320 |
| 106 | MP0002114_abnormal_axial_skeleton | 0.77393223 |
| 107 | MP0001485_abnormal_pinna_reflex | 0.76662689 |
| 108 | MP0003806_abnormal_nucleotide_metabolis | 0.75832161 |
| 109 | MP0002736_abnormal_nociception_after | 0.75775449 |
| 110 | MP0000358_abnormal_cell_content/ | 0.75141473 |
| 111 | MP0009703_decreased_birth_body | 0.74207220 |
| 112 | MP0009333_abnormal_splenocyte_physiolog | 0.74034670 |
| 113 | MP0009250_abnormal_appendicular_skeleto | 0.72486598 |
| 114 | MP0010368_abnormal_lymphatic_system | 0.72209518 |
| 115 | MP0002751_abnormal_autonomic_nervous | 0.72018907 |
| 116 | MP0000762_abnormal_tongue_morphology | 0.71387576 |
| 117 | MP0005248_abnormal_Harderian_gland | 0.70605402 |
| 118 | MP0003878_abnormal_ear_physiology | 0.70598395 |
| 119 | MP0005377_hearing/vestibular/ear_phenot | 0.70598395 |
| 120 | MP0000631_abnormal_neuroendocrine_gland | 0.70525967 |
| 121 | MP0002089_abnormal_postnatal_growth/wei | 0.70523876 |
| 122 | MP0002722_abnormal_immune_system | 0.68899219 |
| 123 | MP0002210_abnormal_sex_determination | 0.68874573 |
| 124 | MP0003938_abnormal_ear_development | 0.68684639 |
| 125 | MP0000778_abnormal_nervous_system | 0.68647151 |
| 126 | MP0002398_abnormal_bone_marrow | 0.68324796 |
| 127 | MP0001545_abnormal_hematopoietic_system | 0.68017957 |
| 128 | MP0005397_hematopoietic_system_phenotyp | 0.68017957 |
| 129 | MP0002102_abnormal_ear_morphology | 0.67977687 |
| 130 | MP0002234_abnormal_pharynx_morphology | 0.67727503 |
| 131 | MP0000534_abnormal_ureter_morphology | 0.66842840 |
| 132 | MP0001879_abnormal_lymphatic_vessel | 0.66259322 |
| 133 | MP0005503_abnormal_tendon_morphology | 0.65027231 |
| 134 | MP0009379_abnormal_foot_pigmentation | 0.65024590 |
| 135 | MP0001119_abnormal_female_reproductive | 0.62615199 |
| 136 | MP0002081_perinatal_lethality | 0.62003349 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 4.02169631 |
| 2 | Abnormality of the labia minora (HP:0012880) | 3.61551768 |
| 3 | Increased nuchal translucency (HP:0010880) | 3.58381268 |
| 4 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.48938652 |
| 5 | Short 4th metacarpal (HP:0010044) | 3.48938652 |
| 6 | Cortical dysplasia (HP:0002539) | 3.43438668 |
| 7 | Renal duplication (HP:0000075) | 3.25427876 |
| 8 | Selective tooth agenesis (HP:0001592) | 3.22908321 |
| 9 | Colon cancer (HP:0003003) | 3.11488562 |
| 10 | Abnormal lung lobation (HP:0002101) | 3.07408085 |
| 11 | Chromsome breakage (HP:0040012) | 2.98486856 |
| 12 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.92872662 |
| 13 | Septo-optic dysplasia (HP:0100842) | 2.91774362 |
| 14 | Patellar aplasia (HP:0006443) | 2.90650968 |
| 15 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.77217488 |
| 16 | Abnormal number of incisors (HP:0011064) | 2.77150210 |
| 17 | Proximal placement of thumb (HP:0009623) | 2.62790027 |
| 18 | Meckel diverticulum (HP:0002245) | 2.62739358 |
| 19 | Deviation of the thumb (HP:0009603) | 2.60188717 |
| 20 | Small intestinal stenosis (HP:0012848) | 2.59180455 |
| 21 | Duodenal stenosis (HP:0100867) | 2.59180455 |
| 22 | Medulloblastoma (HP:0002885) | 2.52573801 |
| 23 | Abnormality of the ileum (HP:0001549) | 2.52511440 |
| 24 | Acute necrotizing encephalopathy (HP:0006965) | 2.50413826 |
| 25 | Degeneration of anterior horn cells (HP:0002398) | 2.48281524 |
| 26 | Abnormality of the anterior horn cell (HP:0006802) | 2.48281524 |
| 27 | Abnormality of the 4th metacarpal (HP:0010012) | 2.44128497 |
| 28 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.43827709 |
| 29 | Hypoplastic pelvis (HP:0008839) | 2.43316223 |
| 30 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.41748058 |
| 31 | Absent septum pellucidum (HP:0001331) | 2.39307595 |
| 32 | 11 pairs of ribs (HP:0000878) | 2.36418938 |
| 33 | Atresia of the external auditory canal (HP:0000413) | 2.36346581 |
| 34 | High pitched voice (HP:0001620) | 2.31691727 |
| 35 | Abnormality of the duodenum (HP:0002246) | 2.30621958 |
| 36 | Ectopic kidney (HP:0000086) | 2.29989758 |
| 37 | Acute encephalopathy (HP:0006846) | 2.29590272 |
| 38 | Embryonal renal neoplasm (HP:0011794) | 2.29280686 |
| 39 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.28133879 |
| 40 | Absent radius (HP:0003974) | 2.26332970 |
| 41 | Myelodysplasia (HP:0002863) | 2.25948009 |
| 42 | Hyperacusis (HP:0010780) | 2.25703261 |
| 43 | Ependymoma (HP:0002888) | 2.25496827 |
| 44 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.24356488 |
| 45 | Duplication of thumb phalanx (HP:0009942) | 2.23941749 |
| 46 | Oral leukoplakia (HP:0002745) | 2.22657480 |
| 47 | Abnormality of chromosome stability (HP:0003220) | 2.22575547 |
| 48 | Abnormality of the septum pellucidum (HP:0007375) | 2.21923882 |
| 49 | Carpal bone hypoplasia (HP:0001498) | 2.20960238 |
| 50 | Abnormality of the calcaneus (HP:0008364) | 2.20776542 |
| 51 | Protrusio acetabuli (HP:0003179) | 2.19565695 |
| 52 | Short middle phalanx of the 5th finger (HP:0004220) | 2.14198855 |
| 53 | Aplasia involving forearm bones (HP:0009822) | 2.12231345 |
| 54 | Absent forearm bone (HP:0003953) | 2.12231345 |
| 55 | Stenosis of the external auditory canal (HP:0000402) | 2.11938674 |
| 56 | Neoplasm of the pancreas (HP:0002894) | 2.11032441 |
| 57 | Absent thumb (HP:0009777) | 2.10347036 |
| 58 | Birth length less than 3rd percentile (HP:0003561) | 2.10076876 |
| 59 | Missing ribs (HP:0000921) | 2.10067330 |
| 60 | Maternal diabetes (HP:0009800) | 2.09585597 |
| 61 | Mesomelia (HP:0003027) | 2.07717550 |
| 62 | Volvulus (HP:0002580) | 2.07088434 |
| 63 | Tracheoesophageal fistula (HP:0002575) | 2.07074026 |
| 64 | Abnormal number of erythroid precursors (HP:0012131) | 2.07052029 |
| 65 | Increased density of long bones (HP:0006392) | 2.03720012 |
| 66 | Sloping forehead (HP:0000340) | 2.03255993 |
| 67 | Breast hypoplasia (HP:0003187) | 2.01934131 |
| 68 | Holoprosencephaly (HP:0001360) | 2.01856535 |
| 69 | Multiple enchondromatosis (HP:0005701) | 2.01773163 |
| 70 | Broad distal phalanx of finger (HP:0009836) | 1.99569276 |
| 71 | Abnormality of the preputium (HP:0100587) | 1.98911853 |
| 72 | Partial duplication of thumb phalanx (HP:0009944) | 1.97299529 |
| 73 | Pallor (HP:0000980) | 1.96833683 |
| 74 | Short 5th finger (HP:0009237) | 1.95506131 |
| 75 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.95210774 |
| 76 | Absent epiphyses (HP:0010577) | 1.95210774 |
| 77 | Hemivertebrae (HP:0002937) | 1.95188786 |
| 78 | Esophageal atresia (HP:0002032) | 1.94221036 |
| 79 | Intestinal polyp (HP:0005266) | 1.93385436 |
| 80 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.93145510 |
| 81 | Partial duplication of the phalanx of hand (HP:0009999) | 1.91144174 |
| 82 | Spastic diplegia (HP:0001264) | 1.90748367 |
| 83 | Hyperglycinemia (HP:0002154) | 1.90442899 |
| 84 | Abnormality of abdominal situs (HP:0011620) | 1.90149423 |
| 85 | Abdominal situs inversus (HP:0003363) | 1.90149423 |
| 86 | Facial cleft (HP:0002006) | 1.90059095 |
| 87 | Impulsivity (HP:0100710) | 1.88775287 |
| 88 | Intestinal polyposis (HP:0200008) | 1.88532878 |
| 89 | Agnosia (HP:0010524) | 1.88404067 |
| 90 | Skull defect (HP:0001362) | 1.88298347 |
| 91 | Irregular epiphyses (HP:0010582) | 1.87725385 |
| 92 | Glioma (HP:0009733) | 1.87224037 |
| 93 | Triphalangeal thumb (HP:0001199) | 1.86736084 |
| 94 | Mitochondrial inheritance (HP:0001427) | 1.86424998 |
| 95 | Shallow orbits (HP:0000586) | 1.86291333 |
| 96 | Horseshoe kidney (HP:0000085) | 1.86182390 |
| 97 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.84472833 |
| 98 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.83283372 |
| 99 | Optic nerve coloboma (HP:0000588) | 1.83149501 |
| 100 | Pendular nystagmus (HP:0012043) | 1.83000204 |
| 101 | Abnormality of the carotid arteries (HP:0005344) | 1.82741683 |
| 102 | Increased hepatocellular lipid droplets (HP:0006565) | 1.82612857 |
| 103 | Rhabdomyosarcoma (HP:0002859) | 1.82398762 |
| 104 | Premature graying of hair (HP:0002216) | 1.81680178 |
| 105 | High anterior hairline (HP:0009890) | 1.81250633 |
| 106 | Dandy-Walker malformation (HP:0001305) | 1.81232983 |
| 107 | Preaxial hand polydactyly (HP:0001177) | 1.81127034 |
| 108 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.80344701 |
| 109 | Supernumerary spleens (HP:0009799) | 1.79111767 |
| 110 | Bilateral microphthalmos (HP:0007633) | 1.78827565 |
| 111 | Cafe-au-lait spot (HP:0000957) | 1.78615298 |
| 112 | Progressive macrocephaly (HP:0004481) | 1.78531484 |
| 113 | Anophthalmia (HP:0000528) | 1.78208377 |
| 114 | Short thumb (HP:0009778) | 1.77891138 |
| 115 | Trismus (HP:0000211) | 1.77691878 |
| 116 | Macrocytic anemia (HP:0001972) | 1.77243694 |
| 117 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.76878870 |
| 118 | Broad phalanges of the hand (HP:0009768) | 1.76709716 |
| 119 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.76531923 |
| 120 | Neoplasm of the colon (HP:0100273) | 1.76054813 |
| 121 | Increased CSF lactate (HP:0002490) | 1.75692273 |
| 122 | Aplastic anemia (HP:0001915) | 1.75226502 |
| 123 | Embryonal neoplasm (HP:0002898) | 1.74810662 |
| 124 | Anencephaly (HP:0002323) | 1.74787809 |
| 125 | Bifid tongue (HP:0010297) | 1.74078182 |
| 126 | Cutaneous melanoma (HP:0012056) | 1.73551730 |
| 127 | Ovarian neoplasm (HP:0100615) | 1.72845072 |
| 128 | Facial hemangioma (HP:0000329) | 1.71887153 |
| 129 | Preauricular skin tag (HP:0000384) | 1.71721674 |
| 130 | Rough bone trabeculation (HP:0100670) | 1.69216782 |
| 131 | Syringomyelia (HP:0003396) | 1.69158003 |
| 132 | Spinal cord lesions (HP:0100561) | 1.69158003 |
| 133 | Cerebral edema (HP:0002181) | 1.68889290 |
| 134 | Broad thumb (HP:0011304) | 1.68124453 |
| 135 | Basal cell carcinoma (HP:0002671) | 1.66630824 |
| 136 | Trigonocephaly (HP:0000243) | 1.66222799 |
| 137 | Duplicated collecting system (HP:0000081) | 1.65822440 |
| 138 | Skin tags (HP:0010609) | 1.65153708 |
| 139 | Bone marrow hypocellularity (HP:0005528) | 1.64805827 |
| 140 | Slender long bone (HP:0003100) | 1.64597174 |
| 141 | Lipid accumulation in hepatocytes (HP:0006561) | 1.64139376 |
| 142 | Sclerocornea (HP:0000647) | 1.62943459 |
| 143 | Glossoptosis (HP:0000162) | 1.62817259 |
| 144 | Small epiphyses (HP:0010585) | 1.59121675 |
| 145 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.57977347 |
| 146 | Rectovaginal fistula (HP:0000143) | 1.57742200 |
| 147 | Rectal fistula (HP:0100590) | 1.57742200 |
| 148 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.56685676 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 6.48596602 |
| 2 | CDC7 | 3.89347829 |
| 3 | WEE1 | 3.72419274 |
| 4 | NEK2 | 3.49768691 |
| 5 | VRK2 | 2.94239034 |
| 6 | NEK1 | 2.54353283 |
| 7 | BRSK1 | 2.52541092 |
| 8 | BRSK2 | 2.42970263 |
| 9 | TTK | 2.42025006 |
| 10 | MAP3K10 | 2.26632657 |
| 11 | PLK1 | 2.11761973 |
| 12 | TLK1 | 2.08533674 |
| 13 | STK10 | 2.05349050 |
| 14 | TESK2 | 2.00920368 |
| 15 | MKNK1 | 1.96576121 |
| 16 | AURKB | 1.95673108 |
| 17 | EEF2K | 1.89390145 |
| 18 | SRPK1 | 1.74295344 |
| 19 | MAP3K8 | 1.73961595 |
| 20 | PASK | 1.73454076 |
| 21 | TAF1 | 1.72312166 |
| 22 | CCNB1 | 1.66588039 |
| 23 | PKN2 | 1.66011948 |
| 24 | AURKA | 1.63209105 |
| 25 | PLK3 | 1.61463293 |
| 26 | CDK7 | 1.52352349 |
| 27 | PAK4 | 1.51398381 |
| 28 | TGFBR1 | 1.46307324 |
| 29 | TRIB3 | 1.43744214 |
| 30 | RPS6KA4 | 1.43420225 |
| 31 | STK4 | 1.43100045 |
| 32 | ATR | 1.37033712 |
| 33 | PLK4 | 1.35726884 |
| 34 | MELK | 1.32134511 |
| 35 | VRK1 | 1.26096421 |
| 36 | CDK4 | 1.25403850 |
| 37 | EIF2AK1 | 1.24058225 |
| 38 | NME1 | 1.18889529 |
| 39 | RPS6KB2 | 1.18027601 |
| 40 | NME2 | 1.17000717 |
| 41 | TRIM28 | 1.15473182 |
| 42 | CHEK2 | 1.13715448 |
| 43 | CLK1 | 1.13378350 |
| 44 | TESK1 | 1.12851355 |
| 45 | CDK12 | 1.10126636 |
| 46 | LRRK2 | 1.08978429 |
| 47 | CHEK1 | 1.07753212 |
| 48 | MKNK2 | 1.04015885 |
| 49 | TSSK6 | 1.02098137 |
| 50 | SCYL2 | 1.01044272 |
| 51 | NUAK1 | 1.00409827 |
| 52 | DYRK2 | 0.97365368 |
| 53 | WNK3 | 0.94717421 |
| 54 | TNIK | 0.94618844 |
| 55 | CDK6 | 0.94004997 |
| 56 | ACVR1B | 0.90106251 |
| 57 | PAK1 | 0.83804490 |
| 58 | PNCK | 0.83022499 |
| 59 | FLT3 | 0.82581570 |
| 60 | DYRK3 | 0.81842698 |
| 61 | MAP2K3 | 0.79197458 |
| 62 | TTN | 0.78569684 |
| 63 | ILK | 0.78184848 |
| 64 | KDR | 0.77317456 |
| 65 | CDK2 | 0.73071120 |
| 66 | MST4 | 0.72077293 |
| 67 | CDK8 | 0.69155785 |
| 68 | PBK | 0.68812423 |
| 69 | ATM | 0.67687411 |
| 70 | CDK1 | 0.67002298 |
| 71 | LIMK1 | 0.65371124 |
| 72 | AKT2 | 0.64199730 |
| 73 | PAK2 | 0.63749933 |
| 74 | ERBB4 | 0.59108720 |
| 75 | PTK6 | 0.58659327 |
| 76 | CSNK1G1 | 0.58527086 |
| 77 | STK16 | 0.56637564 |
| 78 | CDK19 | 0.55998043 |
| 79 | MARK3 | 0.55784075 |
| 80 | EIF2AK2 | 0.55262765 |
| 81 | EPHB2 | 0.54945688 |
| 82 | BRD4 | 0.54753748 |
| 83 | FGFR1 | 0.53995613 |
| 84 | TAOK2 | 0.53462506 |
| 85 | BMPR1B | 0.50930543 |
| 86 | CSNK1G3 | 0.49625542 |
| 87 | STK3 | 0.49581717 |
| 88 | PDK2 | 0.49474931 |
| 89 | LATS2 | 0.49081795 |
| 90 | BCKDK | 0.48504361 |
| 91 | ZAK | 0.48126234 |
| 92 | DYRK1B | 0.47369948 |
| 93 | SMG1 | 0.47041268 |
| 94 | BTK | 0.46554003 |
| 95 | BCR | 0.45317212 |
| 96 | NEK9 | 0.44993931 |
| 97 | PDGFRA | 0.43591450 |
| 98 | CSNK2A1 | 0.43150464 |
| 99 | ERBB3 | 0.43001823 |
| 100 | CDK15 | 0.42862230 |
| 101 | CDK11A | 0.42422887 |
| 102 | EIF2AK3 | 0.41778410 |
| 103 | CDK18 | 0.41447415 |
| 104 | MINK1 | 0.39478205 |
| 105 | CSNK1G2 | 0.39336368 |
| 106 | MAPKAPK2 | 0.39073693 |
| 107 | PIM1 | 0.38636163 |
| 108 | EPHA4 | 0.37815154 |
| 109 | MTOR | 0.37659244 |
| 110 | PLK2 | 0.37086062 |
| 111 | CDK14 | 0.36445619 |
| 112 | MAPK11 | 0.35597108 |
| 113 | MAP3K11 | 0.34901124 |
| 114 | CSNK1E | 0.34515165 |
| 115 | CSNK2A2 | 0.34189228 |
| 116 | BRAF | 0.33387698 |
| 117 | ERBB2 | 0.32761163 |
| 118 | ALK | 0.32626299 |
| 119 | MAP4K1 | 0.31378910 |
| 120 | YES1 | 0.31269940 |
| 121 | CDK3 | 0.30658894 |
| 122 | CSNK1A1L | 0.30203171 |
| 123 | STK38L | 0.30150078 |
| 124 | CSF1R | 0.30014394 |
| 125 | PRKCI | 0.28727579 |
| 126 | TIE1 | 0.28144532 |
| 127 | PRKCG | 0.25268523 |
| 128 | AKT1 | 0.24660032 |
| 129 | KSR1 | 0.24408629 |
| 130 | PRKDC | 0.23527651 |
| 131 | FGFR2 | 0.23293037 |
| 132 | MET | 0.22426196 |
| 133 | MAP2K7 | 0.17868247 |
| 134 | DMPK | 0.17371087 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.02034547 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.11996422 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.50573821 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.49570111 |
| 5 | Base excision repair_Homo sapiens_hsa03410 | 3.47466464 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 3.16403183 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 3.12645941 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.89891646 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.58020260 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.46861769 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.46732121 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.27637216 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.19278995 |
| 14 | Proteasome_Homo sapiens_hsa03050 | 2.17095560 |
| 15 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.95323212 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.90743345 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.90573379 |
| 18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.89402137 |
| 19 | Parkinsons disease_Homo sapiens_hsa05012 | 1.87761670 |
| 20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.87241812 |
| 21 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.81129589 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.80912503 |
| 23 | Protein export_Homo sapiens_hsa03060 | 1.72267196 |
| 24 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.68141510 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.63917933 |
| 26 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.59916912 |
| 27 | Huntingtons disease_Homo sapiens_hsa05016 | 1.56953000 |
| 28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.53898682 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.51069001 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50306706 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.40367689 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35835089 |
| 33 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.34191432 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.31095833 |
| 35 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.28519628 |
| 36 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.28499321 |
| 37 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.28426421 |
| 38 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.25541820 |
| 39 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.23318779 |
| 40 | HTLV-I infection_Homo sapiens_hsa05166 | 1.21697210 |
| 41 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.21521683 |
| 42 | Basal transcription factors_Homo sapiens_hsa03022 | 1.15441818 |
| 43 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.12982380 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12012820 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.10892314 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.09576522 |
| 47 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.09281939 |
| 48 | Alzheimers disease_Homo sapiens_hsa05010 | 1.08685736 |
| 49 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.06207131 |
| 50 | Sulfur relay system_Homo sapiens_hsa04122 | 1.03715550 |
| 51 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.02366486 |
| 52 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.98854883 |
| 53 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.94258467 |
| 54 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.91933514 |
| 55 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.91073777 |
| 56 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.90111026 |
| 57 | Alcoholism_Homo sapiens_hsa05034 | 0.89144231 |
| 58 | Bladder cancer_Homo sapiens_hsa05219 | 0.85083606 |
| 59 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.84661187 |
| 60 | Purine metabolism_Homo sapiens_hsa00230 | 0.83463046 |
| 61 | Colorectal cancer_Homo sapiens_hsa05210 | 0.83408554 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.81675763 |
| 63 | Thyroid cancer_Homo sapiens_hsa05216 | 0.78660570 |
| 64 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.77759629 |
| 65 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.76673514 |
| 66 | Viral myocarditis_Homo sapiens_hsa05416 | 0.75059467 |
| 67 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.73778431 |
| 68 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.73395087 |
| 69 | Shigellosis_Homo sapiens_hsa05131 | 0.71887159 |
| 70 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.70776130 |
| 71 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.69505273 |
| 72 | Adherens junction_Homo sapiens_hsa04520 | 0.65710988 |
| 73 | Apoptosis_Homo sapiens_hsa04210 | 0.64586921 |
| 74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.63252414 |
| 75 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.62586827 |
| 76 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.62409667 |
| 77 | Hepatitis B_Homo sapiens_hsa05161 | 0.61108379 |
| 78 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.60198482 |
| 79 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.60184623 |
| 80 | Pathways in cancer_Homo sapiens_hsa05200 | 0.59536421 |
| 81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55404225 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.55161471 |
| 83 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.53287066 |
| 84 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.52282287 |
| 85 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.50867342 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49687027 |
| 87 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.49334803 |
| 88 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.48461492 |
| 89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48284961 |
| 90 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.47840565 |
| 91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47577278 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47546165 |
| 93 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.45027353 |
| 94 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.44955045 |
| 95 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.44614259 |
| 96 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.44035796 |
| 97 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.42675527 |
| 98 | Focal adhesion_Homo sapiens_hsa04510 | 0.38870506 |
| 99 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.37734949 |
| 100 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37680945 |
| 101 | Lysine degradation_Homo sapiens_hsa00310 | 0.37375990 |
| 102 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.37019792 |
| 103 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36275435 |
| 104 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.35947467 |
| 105 | Tight junction_Homo sapiens_hsa04530 | 0.35075621 |
| 106 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.34968948 |
| 107 | Prostate cancer_Homo sapiens_hsa05215 | 0.34446753 |
| 108 | Melanoma_Homo sapiens_hsa05218 | 0.34194327 |
| 109 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33976251 |
| 110 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.32995871 |
| 111 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.32694647 |
| 112 | Endometrial cancer_Homo sapiens_hsa05213 | 0.32622022 |
| 113 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.31462998 |
| 114 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31148084 |
| 115 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.30341240 |
| 116 | Measles_Homo sapiens_hsa05162 | 0.28796236 |
| 117 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.28112228 |
| 118 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.28034130 |
| 119 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.27861507 |
| 120 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.26950956 |
| 121 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25973389 |
| 122 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.25898632 |
| 123 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.25851437 |
| 124 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.24670130 |
| 125 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.24521393 |
| 126 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.24327578 |
| 127 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.22995594 |
| 128 | Influenza A_Homo sapiens_hsa05164 | 0.22570448 |
| 129 | Leishmaniasis_Homo sapiens_hsa05140 | 0.21679929 |
| 130 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.20951122 |
| 131 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.20769491 |
| 132 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.20182186 |
| 133 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.19272994 |
| 134 | Glioma_Homo sapiens_hsa05214 | 0.19082066 |
| 135 | Platelet activation_Homo sapiens_hsa04611 | 0.18967230 |
| 136 | Peroxisome_Homo sapiens_hsa04146 | 0.18103259 |
| 137 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.17976889 |
| 138 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.17600564 |
| 139 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.16088381 |
| 140 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.15914455 |
| 141 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.15345350 |
| 142 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.13244949 |
| 143 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.13158874 |
| 144 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.12083032 |
| 145 | Phototransduction_Homo sapiens_hsa04744 | 0.11242192 |

