FAM65A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)8.91611771
2glomerular epithelial cell development (GO:0072310)8.16479153
3glomerular basement membrane development (GO:0032836)7.52142258
4vascular endothelial growth factor signaling pathway (GO:0038084)4.29429500
5plasma membrane repair (GO:0001778)3.94234495
6endothelial cell chemotaxis (GO:0035767)3.92281209
7positive regulation of histone deacetylation (GO:0031065)3.79648948
8protein localization to endosome (GO:0036010)3.70171189
9venous blood vessel morphogenesis (GO:0048845)3.67809431
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.54876135
11negative regulation of cell size (GO:0045792)3.50564535
12vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.49688775
13cardiac myofibril assembly (GO:0055003)3.49287236
14glomerulus development (GO:0032835)3.45357808
15stress fiber assembly (GO:0043149)3.39854238
16definitive hemopoiesis (GO:0060216)3.36963733
17positive regulation of blood vessel endothelial cell migration (GO:0043536)3.36098416
18regulation of early endosome to late endosome transport (GO:2000641)3.27777707
19sarcomere organization (GO:0045214)3.21603168
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19186630
21antigen processing and presentation via MHC class Ib (GO:0002475)3.17165941
22epithelial cell differentiation involved in kidney development (GO:0035850)3.14210534
23positive regulation of receptor recycling (GO:0001921)3.10648091
24blood vessel maturation (GO:0001955)3.09520667
25negative regulation of erythrocyte differentiation (GO:0045647)3.09259221
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.08564110
27regulation of synapse structural plasticity (GO:0051823)3.07488089
28adherens junction assembly (GO:0034333)3.04901076
29epithelial cell-cell adhesion (GO:0090136)3.03666155
30positive regulation of protein deacetylation (GO:0090312)3.03558672
31positive regulation of lamellipodium assembly (GO:0010592)3.03100574
32negative regulation of vascular permeability (GO:0043116)3.00438678
33cell-substrate adherens junction assembly (GO:0007045)2.99893596
34focal adhesion assembly (GO:0048041)2.99893596
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99357301
36coronary vasculature morphogenesis (GO:0060977)2.98336034
37neuron projection extension involved in neuron projection guidance (GO:1902284)2.93304842
38axon extension involved in axon guidance (GO:0048846)2.93304842
39activation of protein kinase A activity (GO:0034199)2.93300807
40mannose metabolic process (GO:0006013)2.88279880
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87613617
42glucocorticoid receptor signaling pathway (GO:0042921)2.87097508
43cell communication by electrical coupling (GO:0010644)2.86615510
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85988323
45cell-cell junction maintenance (GO:0045217)2.83835346
46lymphangiogenesis (GO:0001946)2.81748072
47sprouting angiogenesis (GO:0002040)2.81126796
48semaphorin-plexin signaling pathway (GO:0071526)2.80875579
49heart trabecula formation (GO:0060347)2.79493315
50regulation of p38MAPK cascade (GO:1900744)2.77880085
51response to peptidoglycan (GO:0032494)2.76025939
52sodium ion export (GO:0071436)2.75974412
53renal filtration (GO:0097205)2.75082147
54embryonic hemopoiesis (GO:0035162)2.74151558
55megakaryocyte development (GO:0035855)2.72863449
56regulation of ARF protein signal transduction (GO:0032012)2.72687256
57protein retention in ER lumen (GO:0006621)2.72385098
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72184700
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72184700
60synaptic vesicle maturation (GO:0016188)2.71357150
61cortical actin cytoskeleton organization (GO:0030866)2.69868080
62positive regulation of lamellipodium organization (GO:1902745)2.69827172
63patterning of blood vessels (GO:0001569)2.68266478
64response to laminar fluid shear stress (GO:0034616)2.68019387
65synaptic vesicle docking involved in exocytosis (GO:0016081)2.67751906
66cardiac muscle contraction (GO:0060048)2.65475231
67lymph vessel development (GO:0001945)2.63173735
68regulation of axon guidance (GO:1902667)2.58660655
69skin morphogenesis (GO:0043589)2.58420303
70barbed-end actin filament capping (GO:0051016)2.57774120
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56263171
72positive regulation of axon extension (GO:0045773)2.55925731
73regulation of T-helper 2 cell differentiation (GO:0045628)2.55721338
74substrate-dependent cell migration (GO:0006929)2.53258886
75response to muramyl dipeptide (GO:0032495)2.53125585
76germ cell migration (GO:0008354)2.51098102
77cardiac muscle cell proliferation (GO:0060038)2.50736316
78positive regulation of vascular permeability (GO:0043117)2.50564306
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49864750
80regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49698492
81positive regulation of protein dephosphorylation (GO:0035307)2.48717556
82protein targeting to plasma membrane (GO:0072661)2.48400096
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46579337
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.46579337
85modulation by symbiont of host immune response (GO:0052553)2.46579337
86positive regulation by symbiont of host defense response (GO:0052509)2.46579337
87modulation by symbiont of host defense response (GO:0052031)2.46579337
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46579337
89peptidyl-lysine dimethylation (GO:0018027)2.45800134
90myofibril assembly (GO:0030239)2.45371762
91regulation of erythrocyte differentiation (GO:0045646)2.45300734
92cell migration involved in sprouting angiogenesis (GO:0002042)2.44922655
93macrophage activation involved in immune response (GO:0002281)2.43546487
94positive regulation of fibroblast migration (GO:0010763)2.43172971
95positive regulation of Rap GTPase activity (GO:0032854)2.42702438
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42018282
97locomotory exploration behavior (GO:0035641)2.41470038
98endocytic recycling (GO:0032456)2.41172377
99atrioventricular valve morphogenesis (GO:0003181)2.40905302
100cell-substrate junction assembly (GO:0007044)2.40350679
101positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39788058
102blood vessel endothelial cell migration (GO:0043534)2.39342085
103ribosomal small subunit assembly (GO:0000028)2.39288680
104cortical cytoskeleton organization (GO:0030865)2.37936059
105regulation of ARF GTPase activity (GO:0032312)2.37781247
106regulation of vascular permeability (GO:0043114)2.36731662
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.36094044
108cardiac muscle cell development (GO:0055013)2.34453364
109protein heterotrimerization (GO:0070208)2.33497328
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33477707
111NADH metabolic process (GO:0006734)2.32699732
112regulation of leukocyte degranulation (GO:0043300)2.31349999
113cell volume homeostasis (GO:0006884)2.30488480
114positive regulation of extracellular matrix organization (GO:1903055)2.30309624
115basement membrane organization (GO:0071711)2.30016670
116virion attachment to host cell (GO:0019062)2.29296128
117adhesion of symbiont to host cell (GO:0044650)2.29296128
118regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.29155459
119oxygen transport (GO:0015671)2.29121864
120germinal center formation (GO:0002467)2.28347343
121positive regulation of synapse maturation (GO:0090129)2.28300968
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.27922784
123adenosine receptor signaling pathway (GO:0001973)2.27620353
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26236748
125negative regulation of actin filament bundle assembly (GO:0032232)2.26175294
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25484211
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.25054404
128response to fluid shear stress (GO:0034405)2.24630137
129actomyosin structure organization (GO:0031032)2.24377285
130heparin biosynthetic process (GO:0030210)2.23506248
131heparin metabolic process (GO:0030202)2.23506248
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23166913
133embryonic heart tube development (GO:0035050)2.22981661
134hyaluronan catabolic process (GO:0030214)2.22362700
135cAMP biosynthetic process (GO:0006171)2.22102564
136regulation of macrophage cytokine production (GO:0010935)2.21642097
137activation of Rac GTPase activity (GO:0032863)2.20973096
138lamellipodium assembly (GO:0030032)2.20951646
139endothelium development (GO:0003158)2.20821162
140adhesion of symbiont to host (GO:0044406)2.20798112
141modulation by symbiont of host cellular process (GO:0044068)2.19845884
142actin filament bundle assembly (GO:0051017)2.19613664
143actin filament bundle organization (GO:0061572)2.19613664
144negative regulation of heart growth (GO:0061117)2.19090942
145negative regulation of cardiac muscle tissue growth (GO:0055022)2.19090942
146mitotic G1 DNA damage checkpoint (GO:0031571)2.18995918
147regulation of extracellular matrix disassembly (GO:0010715)2.18373020
148cell migration involved in heart development (GO:0060973)2.18118073
149cell adhesion mediated by integrin (GO:0033627)2.17772763
150signal complex assembly (GO:0007172)2.17629807
151negative regulation of homotypic cell-cell adhesion (GO:0034111)2.16281527
152activation of MAPKKK activity (GO:0000185)2.14682172
153NIK/NF-kappaB signaling (GO:0038061)2.13234453
154regulation of mast cell degranulation (GO:0043304)2.13135500
155synaptic vesicle exocytosis (GO:0016079)2.12998143
156cell junction maintenance (GO:0034331)2.11659603
157modulation by virus of host morphology or physiology (GO:0019048)2.10167879
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.09937419
159detection of molecule of bacterial origin (GO:0032490)2.06987725
160fibril organization (GO:0097435)2.06422662
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.05792458
162extracellular fibril organization (GO:0043206)2.04700688
163negative regulation of fatty acid transport (GO:2000192)2.04630305
164regulation of regulated secretory pathway (GO:1903305)2.04386653
165glutamate secretion (GO:0014047)2.04068260
166activation of JUN kinase activity (GO:0007257)2.03877171
167positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.01517613
168actin filament depolymerization (GO:0030042)2.01245167
169apoptotic cell clearance (GO:0043277)2.00713696
170cellular response to catecholamine stimulus (GO:0071870)2.00291750
171cellular response to monoamine stimulus (GO:0071868)2.00291750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.37218285
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.08137128
3VDR_21846776_ChIP-Seq_THP-1_Human3.05125900
4SCL_19346495_ChIP-Seq_HPC-7_Human3.00471014
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75606749
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.72845846
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66793640
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.60499105
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.49866866
10* KDM2B_26808549_Chip-Seq_DND41_Human2.49647836
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.40142144
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37775965
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32329621
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31576374
15LXR_22292898_ChIP-Seq_THP-1_Human2.31145272
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20602455
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.16064989
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.14711761
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09439570
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05092181
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02507293
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98541045
23ZNF263_19887448_ChIP-Seq_K562_Human1.96547450
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96235208
25E2F7_22180533_ChIP-Seq_HELA_Human1.94113589
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85369918
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81859331
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.80414575
29KDM2B_26808549_Chip-Seq_K562_Human1.76918682
30SPI1_23127762_ChIP-Seq_K562_Human1.76115029
31CIITA_25753668_ChIP-Seq_RAJI_Human1.74647468
32VDR_24763502_ChIP-Seq_THP-1_Human1.74217817
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73973834
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73500716
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69962837
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.69611995
37* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68814436
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.61005862
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.59538076
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59315483
41UTX_26944678_Chip-Seq_JUKART_Human1.58904024
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58307936
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.57698370
44* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55907320
45FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.55758257
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55523142
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51892940
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51749645
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.51698097
50MAF_26560356_Chip-Seq_TH1_Human1.45877541
51RACK7_27058665_Chip-Seq_MCF-7_Human1.42825353
52* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41645086
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41533220
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37800797
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.37655315
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37552763
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35304819
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34810588
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.34239138
60CLOCK_20551151_ChIP-Seq_293T_Human1.34045270
61GATA1_19941826_ChIP-Seq_K562_Human1.33491941
62* NCOR1_26117541_ChIP-Seq_K562_Human1.33013971
63MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32999038
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32730893
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31067647
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30151353
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29809557
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.29586202
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28417920
70* TBX20_22328084_ChIP-Seq_HEART_Mouse1.27627588
71* TBX20_22080862_ChIP-Seq_HEART_Mouse1.27627588
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26991650
73CTCF_27219007_Chip-Seq_Bcells_Human1.25583751
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24984685
75* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24648804
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23922648
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23573262
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23204636
79TP53_22127205_ChIP-Seq_IMR90_Human1.22979642
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22021561
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21164635
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.21092310
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20300966
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20046222
85P68_20966046_ChIP-Seq_HELA_Human1.18704474
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18598135
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18387456
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17196473
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15863949
90* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15721007
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15653351
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15415687
93* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15299448
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.14393327
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.14181763
96CREB1_26743006_Chip-Seq_LNCaP_Human1.13138411
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13028238
98MAF_26560356_Chip-Seq_TH2_Human1.11785588
99EZH2_22144423_ChIP-Seq_EOC_Human1.11253103
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.11116319
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10254865
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09497298
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09455921
104* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08437037
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08274030
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08226703
107ATF3_27146783_Chip-Seq_COLON_Human1.08102191
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06727240
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06712367
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.06662307
111* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06318415
112SMC4_20622854_ChIP-Seq_HELA_Human1.06126549
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.06067011
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05640184
115BCL6_27268052_Chip-Seq_Bcells_Human1.04070001
116BCOR_27268052_Chip-Seq_Bcells_Human1.03453985
117* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03312823
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03205434
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01162033
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01132567
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00896109
122CTCF_21964334_Chip-Seq_Bcells_Human1.00791584
123DROSHA_22980978_ChIP-Seq_HELA_Human1.00548568
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00496489
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00488073
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00348016
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98920644
128* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98702835
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98363958
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.98250942
131* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97739990
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96879335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.30634059
2MP0010368_abnormal_lymphatic_system3.67443378
3MP0004859_abnormal_synaptic_plasticity2.90578085
4MP0000751_myopathy2.86092778
5MP0005623_abnormal_meninges_morphology2.83813315
6MP0005058_abnormal_lysosome_morphology2.83474555
7MP0001879_abnormal_lymphatic_vessel2.68142110
8MP0004036_abnormal_muscle_relaxation2.64209650
9MP0002396_abnormal_hematopoietic_system2.61266732
10MP0002837_dystrophic_cardiac_calcinosis2.45719309
11MP0004215_abnormal_myocardial_fiber2.38013006
12MP0004808_abnormal_hematopoietic_stem2.32042832
13MP0006054_spinal_hemorrhage2.29495632
14MP0008961_abnormal_basal_metabolism2.25933118
15MP0003436_decreased_susceptibility_to2.18772425
16MP0009840_abnormal_foam_cell2.08626629
17MP0004272_abnormal_basement_membrane2.05176617
18MP0003279_aneurysm2.04287513
19MP0005397_hematopoietic_system_phenotyp2.02425005
20MP0001545_abnormal_hematopoietic_system2.02425005
21MP0005409_darkened_coat_color2.02409342
22MP0003191_abnormal_cellular_cholesterol2.01987697
23MP0005451_abnormal_body_composition2.01916250
24MP0009278_abnormal_bone_marrow2.01217701
25MP0003566_abnormal_cell_adhesion1.97471281
26MP0002877_abnormal_melanocyte_morpholog1.96279066
27MP0004858_abnormal_nervous_system1.94345846
28MP0005257_abnormal_intraocular_pressure1.91400700
29MP0000749_muscle_degeneration1.90198689
30MP0005330_cardiomyopathy1.89876412
31MP0008775_abnormal_heart_ventricle1.87910355
32MP0008260_abnormal_autophagy1.86299567
33MP0000013_abnormal_adipose_tissue1.83169388
34MP0001849_ear_inflammation1.81781523
35MP0003828_pulmonary_edema1.81719652
36MP0010630_abnormal_cardiac_muscle1.79568313
37MP0004087_abnormal_muscle_fiber1.74852395
38MP0003646_muscle_fatigue1.70213368
39MP0010352_gastrointestinal_tract_polyps1.65435630
40MP0005385_cardiovascular_system_phenoty1.63537673
41MP0001544_abnormal_cardiovascular_syste1.63537673
42MP0003329_amyloid_beta_deposits1.63463248
43MP0003705_abnormal_hypodermis_morpholog1.56506571
44MP0006138_congestive_heart_failure1.56383353
45MP0000747_muscle_weakness1.53420343
46MP0004484_altered_response_of1.50779296
47MP0002972_abnormal_cardiac_muscle1.49233880
48MP0004233_abnormal_muscle_weight1.48014609
49MP0000750_abnormal_muscle_regeneration1.47414322
50MP0002269_muscular_atrophy1.46204979
51MP0003300_gastrointestinal_ulcer1.42920551
52MP0002998_abnormal_bone_remodeling1.42675184
53MP0002106_abnormal_muscle_physiology1.39293895
54MP0005275_abnormal_skin_tensile1.39278851
55MP0003724_increased_susceptibility_to1.38801414
56MP0003075_altered_response_to1.35758167
57MP0001533_abnormal_skeleton_physiology1.35486314
58MP0003879_abnormal_hair_cell1.33286000
59MP0002128_abnormal_blood_circulation1.30906014
60MP0005620_abnormal_muscle_contractility1.29960210
61MP0003303_peritoneal_inflammation1.25858303
62MP0005167_abnormal_blood-brain_barrier1.22994958
63MP0004130_abnormal_muscle_cell1.22838552
64MP0004085_abnormal_heartbeat1.21504671
65MP0003091_abnormal_cell_migration1.21236104
66MP0003122_maternal_imprinting1.21070876
67MP0003221_abnormal_cardiomyocyte_apopto1.20106138
68MP0002419_abnormal_innate_immunity1.19384682
69MP0001958_emphysema1.17685885
70MP0000759_abnormal_skeletal_muscle1.17556570
71MP0000003_abnormal_adipose_tissue1.17325814
72MP0005595_abnormal_vascular_smooth1.17135418
73MP0001542_abnormal_bone_strength1.16987200
74MP0000604_amyloidosis1.16613787
75MP0004947_skin_inflammation1.16347726
76MP0000266_abnormal_heart_morphology1.16173915
77MP0003635_abnormal_synaptic_transmissio1.15231290
78MP0005369_muscle_phenotype1.14096938
79MP0000465_gastrointestinal_hemorrhage1.13324713
80MP0003690_abnormal_glial_cell1.12915815
81MP0005423_abnormal_somatic_nervous1.12348235
82MP0000343_altered_response_to1.12149390
83MP0002295_abnormal_pulmonary_circulatio1.11304089
84MP0002925_abnormal_cardiovascular_devel1.11021963
85MP0002933_joint_inflammation1.10621247
86MP0004510_myositis1.08200354
87MP0002909_abnormal_adrenal_gland1.07072460
88MP0009780_abnormal_chondrocyte_physiolo1.06225620
89MP0003567_abnormal_fetal_cardiomyocyte1.05789385
90MP0002089_abnormal_postnatal_growth/wei1.03525688
91MP0001790_abnormal_immune_system1.03338182
92MP0005387_immune_system_phenotype1.03338182
93MP0003453_abnormal_keratinocyte_physiol1.02680574
94MP0005390_skeleton_phenotype1.01623299
95MP0003137_abnormal_impulse_conducting1.01334391
96MP0000230_abnormal_systemic_arterial0.98966123
97MP0000920_abnormal_myelination0.98687799
98MP0001915_intracranial_hemorrhage0.96516564
99MP0000767_abnormal_smooth_muscle0.96246738
100MP0002332_abnormal_exercise_endurance0.95844502
101MP0005076_abnormal_cell_differentiation0.95544133
102MP0008874_decreased_physiological_sensi0.95528798
103MP0000733_abnormal_muscle_development0.94997858
104MP0005025_abnormal_response_to0.94996726
105MP0009384_cardiac_valve_regurgitation0.93750521
106MP0008770_decreased_survivor_rate0.93592919
107MP0001614_abnormal_blood_vessel0.93146392
108MP0005670_abnormal_white_adipose0.92602814
109MP0000685_abnormal_immune_system0.91981034
110MP0003634_abnormal_glial_cell0.91849233
111MP0000249_abnormal_blood_vessel0.91405693
112MP0000534_abnormal_ureter_morphology0.91227513
113MP0006082_CNS_inflammation0.91181493
114MP0003984_embryonic_growth_retardation0.89445542
115MP0001784_abnormal_fluid_regulation0.87678789
116MP0003045_fibrosis0.87068913
117MP0005166_decreased_susceptibility_to0.86356807
118MP0005164_abnormal_response_to0.85240452
119MP0002896_abnormal_bone_mineralization0.84603311
120MP0008438_abnormal_cutaneous_collagen0.84189505
121MP0005503_abnormal_tendon_morphology0.83695645
122MP0002088_abnormal_embryonic_growth/wei0.82604711
123MP0005000_abnormal_immune_tolerance0.82147986
124MP0002234_abnormal_pharynx_morphology0.81649440
125MP0005666_abnormal_adipose_tissue0.80604206
126MP0001851_eye_inflammation0.80515290
127MP0008004_abnormal_stomach_pH0.79162128
128MP0005508_abnormal_skeleton_morphology0.78528749
129MP0003943_abnormal_hepatobiliary_system0.78327265
130MP0008569_lethality_at_weaning0.77621571
131MP0005464_abnormal_platelet_physiology0.77014906
132MP0002135_abnormal_kidney_morphology0.76857530
133MP0002086_abnormal_extraembryonic_tissu0.76216344
134MP0003448_altered_tumor_morphology0.75106875
135MP0005375_adipose_tissue_phenotype0.73112608
136MP0000678_abnormal_parathyroid_gland0.72727838
137MP0002060_abnormal_skin_morphology0.72530264
138MP0005165_increased_susceptibility_to0.71111087
139MP0002133_abnormal_respiratory_system0.69624105
140MP0005388_respiratory_system_phenotype0.69624105
141MP0002127_abnormal_cardiovascular_syste0.69302231
142MP0003172_abnormal_lysosome_physiology0.69095591
143MP0002970_abnormal_white_adipose0.68717659
144MP0004811_abnormal_neuron_physiology0.68643964
145MP0005023_abnormal_wound_healing0.67638826
146MP0003795_abnormal_bone_structure0.67284567
147MP0002063_abnormal_learning/memory/cond0.67020431
148MP0002249_abnormal_larynx_morphology0.66911555
149MP0005621_abnormal_cell_physiology0.66630713
150MP0002080_prenatal_lethality0.65396279
151MP0004145_abnormal_muscle_electrophysio0.64697136
152MP0003942_abnormal_urinary_system0.64319412
153MP0000703_abnormal_thymus_morphology0.63658236
154MP0001348_abnormal_lacrimal_gland0.63325425
155MP0003283_abnormal_digestive_organ0.62791840
156MP0000858_altered_metastatic_potential0.62069983
157MP0001697_abnormal_embryo_size0.62020987

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)5.72879396
2Focal segmental glomerulosclerosis (HP:0000097)3.64740420
3Lymphangioma (HP:0100764)3.60951250
4Protrusio acetabuli (HP:0003179)3.52023373
5Obstructive sleep apnea (HP:0002870)3.45449648
6Sudden death (HP:0001699)3.24308721
7Cerebral aneurysm (HP:0004944)3.14617975
8Hyperacusis (HP:0010780)3.12059553
9Rapidly progressive (HP:0003678)3.05179827
10Vertebral compression fractures (HP:0002953)2.98244183
11Abnormal albumin level (HP:0012116)2.94928468
12Hypoalbuminemia (HP:0003073)2.94928468
13Ankle contracture (HP:0006466)2.91927001
14Supranuclear gaze palsy (HP:0000605)2.89844445
15Polycythemia (HP:0001901)2.82217572
16Hypoproteinemia (HP:0003075)2.74282073
17Distal lower limb amyotrophy (HP:0008944)2.74044806
18Glomerulosclerosis (HP:0000096)2.72188261
19Ventricular tachycardia (HP:0004756)2.71326448
20Muscle fiber splitting (HP:0003555)2.70553465
21Difficulty climbing stairs (HP:0003551)2.70515290
22Supraventricular arrhythmia (HP:0005115)2.66878714
23Bundle branch block (HP:0011710)2.65291188
24Primary atrial arrhythmia (HP:0001692)2.64965032
25Papilledema (HP:0001085)2.63813831
26Supraventricular tachycardia (HP:0004755)2.61824936
27Abnormality of glycolipid metabolism (HP:0010969)2.61051777
28Abnormality of liposaccharide metabolism (HP:0010968)2.61051777
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.61051777
30Atrial fibrillation (HP:0005110)2.57576386
31Atrioventricular block (HP:0001678)2.56689213
32Broad face (HP:0000283)2.56305548
33Subaortic stenosis (HP:0001682)2.55353037
34Abnormality of the left ventricular outflow tract (HP:0011103)2.55353037
35Dysmetric saccades (HP:0000641)2.55094057
36Distal lower limb muscle weakness (HP:0009053)2.51960947
37Aortic aneurysm (HP:0004942)2.50702154
38Neurofibrillary tangles (HP:0002185)2.50054254
39Limb-girdle muscle atrophy (HP:0003797)2.48895757
40Vascular tortuosity (HP:0004948)2.48698443
41Broad metatarsal (HP:0001783)2.46978358
42Asymmetric septal hypertrophy (HP:0001670)2.45620404
43Dysostosis multiplex (HP:0000943)2.45236268
44Axonal loss (HP:0003447)2.41597079
45Aneurysm (HP:0002617)2.41403222
46Enlarged penis (HP:0000040)2.39992327
47Arterial tortuosity (HP:0005116)2.37722469
48Prolonged bleeding time (HP:0003010)2.35150084
49Cerebral inclusion bodies (HP:0100314)2.33441819
50Fragile skin (HP:0001030)2.32452091
51Increased variability in muscle fiber diameter (HP:0003557)2.32226239
52Distal upper limb amyotrophy (HP:0007149)2.30841493
53Upper limb amyotrophy (HP:0009129)2.30841493
54Abnormality of polysaccharide metabolism (HP:0011012)2.29752528
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29752528
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29752528
57Abnormality of skeletal muscle fiber size (HP:0012084)2.27509590
58Aortic dissection (HP:0002647)2.27121093
59Abnormality of the fingertips (HP:0001211)2.26326851
60Abnormal platelet function (HP:0011869)2.25104408
61Impaired platelet aggregation (HP:0003540)2.25104408
62Mucopolysacchariduria (HP:0008155)2.24978152
63Urinary glycosaminoglycan excretion (HP:0003541)2.24978152
64Acute lymphatic leukemia (HP:0006721)2.24861160
65Shallow orbits (HP:0000586)2.23525951
66Atrophic scars (HP:0001075)2.22990263
67Disproportionate tall stature (HP:0001519)2.21360976
68Achilles tendon contracture (HP:0001771)2.20462532
69Abnormality of cells of the erythroid lineage (HP:0012130)2.18680729
70Peritonitis (HP:0002586)2.18127684
71Lipoatrophy (HP:0100578)2.17910050
72Nuclear cataract (HP:0100018)2.17501616
73Myotonia (HP:0002486)2.17326280
74Mitral regurgitation (HP:0001653)2.16340138
75Wormian bones (HP:0002645)2.15549024
76Abnormal number of erythroid precursors (HP:0012131)2.15237847
77Increased connective tissue (HP:0009025)2.13445015
78Pointed chin (HP:0000307)2.11364295
79Type 1 muscle fiber predominance (HP:0003803)2.10908763
80Difficulty running (HP:0009046)2.08914276
81Heart block (HP:0012722)2.08830332
82Blue sclerae (HP:0000592)2.08537306
83Hyporeflexia of lower limbs (HP:0002600)2.08518713
84Joint stiffness (HP:0001387)2.06040751
85Thin bony cortex (HP:0002753)2.04807507
86Renal duplication (HP:0000075)2.02598792
87Bladder diverticulum (HP:0000015)2.02560589
88Abnormality of the nasal mucosa (HP:0000433)2.01796614
89Visual hallucinations (HP:0002367)1.99848410
90Abnormal atrioventricular conduction (HP:0005150)1.96710681
91Emphysema (HP:0002097)1.94824139
92EMG: myopathic abnormalities (HP:0003458)1.94350506
93Bowel diverticulosis (HP:0005222)1.94245601
94Eczematoid dermatitis (HP:0000976)1.94076419
95Slender build (HP:0001533)1.93247736
96Petechiae (HP:0000967)1.92251413
97Neuronal loss in central nervous system (HP:0002529)1.91879243
98Long eyelashes (HP:0000527)1.91516704
99Abnormality of the calf musculature (HP:0001430)1.91443970
100Spinal canal stenosis (HP:0003416)1.90278682
101Abnormality of the Achilles tendon (HP:0005109)1.89080277
102Ulnar bowing (HP:0003031)1.88238452
103Dilated cardiomyopathy (HP:0001644)1.88173078
104Mitral valve prolapse (HP:0001634)1.88136838
105Macroorchidism (HP:0000053)1.87701648
106Elfin facies (HP:0004428)1.86380478
107Insomnia (HP:0100785)1.85958798
108Centrally nucleated skeletal muscle fibers (HP:0003687)1.85486220
109Short nail (HP:0001799)1.84661330
110Broad palm (HP:0001169)1.84095536
111Exostoses (HP:0100777)1.83222163
112Apathy (HP:0000741)1.82631726
113Spontaneous hematomas (HP:0007420)1.82365211
114Abnormality of macrophages (HP:0004311)1.81858529
115Systemic lupus erythematosus (HP:0002725)1.81093233
116Exercise-induced muscle cramps (HP:0003710)1.80539196
117Visceral angiomatosis (HP:0100761)1.79548867
118Long palpebral fissure (HP:0000637)1.78163855
119Joint laxity (HP:0001388)1.76956234
120Segmental peripheral demyelination/remyelination (HP:0003481)1.76612581
121Hematochezia (HP:0002573)1.76155666
122Hand muscle atrophy (HP:0009130)1.75226499
123Diminished motivation (HP:0000745)1.74884292
124Mildly elevated creatine phosphokinase (HP:0008180)1.74863124
125Increased cerebral lipofuscin (HP:0011813)1.74262517
126Wrist flexion contracture (HP:0001239)1.74014309
127Lymphedema (HP:0001004)1.73933232
128Annular pancreas (HP:0001734)1.73893418
129Hemorrhage of the eye (HP:0011885)1.73766720
130Spondylolisthesis (HP:0003302)1.73733792
131Hypoventilation (HP:0002791)1.73613021
132Hemangiomatosis (HP:0007461)1.72906872
133Progressive muscle weakness (HP:0003323)1.72741323
134J-shaped sella turcica (HP:0002680)1.72357401
135Foot dorsiflexor weakness (HP:0009027)1.70557784
136EMG: neuropathic changes (HP:0003445)1.70161053
137Premature rupture of membranes (HP:0001788)1.69545345
138Hyperextensible skin (HP:0000974)1.69047937
139Genu recurvatum (HP:0002816)1.68193387
140Neoplasm of the heart (HP:0100544)1.67701228
141Calf muscle hypertrophy (HP:0008981)1.67258401
142Interstitial pulmonary disease (HP:0006530)1.66410929
143Amyloidosis (HP:0011034)1.66350935
144Spinal rigidity (HP:0003306)1.65690549
145Lumbar hyperlordosis (HP:0002938)1.65689307
146Dilatation of the ascending aorta (HP:0005111)1.65110454
147Abnormality of the lower motor neuron (HP:0002366)1.64935330
148Hemiplegia (HP:0002301)1.64702307
149Exercise-induced myalgia (HP:0003738)1.64640849
150Biconcave vertebral bodies (HP:0004586)1.64296549
151Cellulitis (HP:0100658)1.64084223
152Abnormality of binocular vision (HP:0011514)1.63910062
153Diplopia (HP:0000651)1.63910062
154Ventricular fibrillation (HP:0001663)1.63811467
155Genetic anticipation (HP:0003743)1.63518344
156Hypercortisolism (HP:0001578)1.63130859
157Ulnar deviation of the wrist (HP:0003049)1.63050347
158Mitral stenosis (HP:0001718)1.62806424
159Ankle clonus (HP:0011448)1.62531240
160Bicuspid aortic valve (HP:0001647)1.62329845
161Easy fatigability (HP:0003388)1.61795241
162Chronic otitis media (HP:0000389)1.61717222
163Lower limb amyotrophy (HP:0007210)1.61615352
164Cervical subluxation (HP:0003308)1.61212173
165Fatigue (HP:0012378)1.60929309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.03762940
2EEF2K3.72652726
3TIE13.65523134
4PRPF4B3.15497347
5PKN23.02130253
6KDR2.84407491
7IRAK32.22028083
8TTN2.21329650
9ICK2.09261663
10PAK42.05103133
11ERN11.95837883
12MYLK1.94189712
13TGFBR21.89011382
14PRKD31.82799345
15MAP3K101.77581035
16EPHB11.74784184
17SCYL21.72502984
18EPHB21.71238536
19TGFBR11.66614345
20SMG11.60568698
21TAOK11.56993009
22SIK31.56082662
23DMPK1.55982617
24MAPKAPK31.54662969
25RIPK41.53267590
26CDK191.52991979
27RIPK11.49810538
28TESK11.48570282
29NEK11.47734582
30ARAF1.46289316
31TAOK21.46152797
32MAP3K31.41756315
33MAP3K131.40806927
34MAP3K71.38669486
35LRRK21.37010140
36ILK1.30176422
37DDR21.28354540
38SIK21.27004696
39FES1.26621434
40KIT1.22550584
41PTK2B1.21234661
42CAMKK11.20781705
43DAPK11.18801511
44PTK21.16642853
45PDGFRA1.16489203
46NTRK31.15265965
47CAMK11.14113015
48RPS6KB21.13338869
49MAP2K31.11610183
50MARK21.10879052
51PAK21.08368944
52PIM21.05680028
53IRAK41.04621306
54IRAK21.04527963
55BLK1.04037517
56MOS1.01279369
57MINK11.01137475
58ALK1.00134501
59TBK10.99303984
60MAP3K60.99240849
61PDPK10.95656405
62WNK40.95107266
63TYK20.94904703
64CAMK1G0.94899278
65RET0.92060743
66MAP3K40.88415824
67PRKD20.88374537
68NTRK10.87265643
69CAMK1D0.87089824
70NME20.83578199
71CAMKK20.83504444
72MAP4K10.82343228
73MATK0.80918755
74PTK60.80623639
75MAP3K120.79824950
76KSR20.78043332
77CSK0.77887484
78MARK10.76620715
79FGFR40.76353280
80RPS6KA20.76135228
81MAPK120.73409112
82CAMK40.71487859
83KSR10.70830227
84PRKCH0.70579583
85MTOR0.70429001
86SGK30.67390940
87HIPK20.67189948
88TNK20.66851370
89MAPK70.66351235
90DYRK1B0.65827642
91TESK20.65189667
92RAF10.63818549
93CDK180.62836426
94BTK0.62528337
95BRSK10.62331909
96CDK40.61157529
97CDK11A0.60823689
98LIMK10.60672119
99PRKD10.60627382
100EPHA20.60035108
101CDK150.59925644
102BRAF0.59901036
103MAP2K40.59702882
104MAP3K140.59383014
105PDK10.59009163
106TYRO30.58928120
107RPS6KL10.58191895
108MAP3K90.57820484
109CDK120.56203797
110PRKG20.55793486
111CDC42BPA0.54416413
112MAP3K110.54203214
113ZAP700.54113336
114PDGFRB0.53399601
115MAPK40.52924845
116LMTK20.52681065
117NEK20.52122095
118CDK140.51970233
119MARK30.51916845
120PAK60.50567998
121RPS6KA40.49447632
122EIF2AK10.48119369
123PAK30.47156447
124PHKG10.46783193
125PHKG20.46783193
126SIK10.46469905
127JAK30.46363832
128ABL20.45915971
129CDK50.45686468
130LATS20.44987744
131ROCK10.44521318
132BMX0.44249577
133UHMK10.42754354
134DAPK30.41538250
135MAPK90.41421291
136DAPK20.40284170
137AKT20.36719053
138CDK60.36661986
139STK380.36321614
140STK110.35216472
141MAP3K10.34831396
142RPS6KC10.34556185

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.14021969
2Other glycan degradation_Homo sapiens_hsa005112.06635167
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.99799369
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99470484
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96984733
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87863582
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75696817
8Focal adhesion_Homo sapiens_hsa045101.66049732
9Osteoclast differentiation_Homo sapiens_hsa043801.62557297
10ECM-receptor interaction_Homo sapiens_hsa045121.58177105
11Glioma_Homo sapiens_hsa052141.56556178
12Chronic myeloid leukemia_Homo sapiens_hsa052201.56409055
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50465790
14Platelet activation_Homo sapiens_hsa046111.50214067
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47667137
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45665372
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43831762
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42184337
19Non-small cell lung cancer_Homo sapiens_hsa052231.34534440
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.33927707
21Prion diseases_Homo sapiens_hsa050201.32177848
22VEGF signaling pathway_Homo sapiens_hsa043701.31890159
23Long-term potentiation_Homo sapiens_hsa047201.31529544
24Circadian entrainment_Homo sapiens_hsa047131.31351192
25mTOR signaling pathway_Homo sapiens_hsa041501.30953321
26Small cell lung cancer_Homo sapiens_hsa052221.27128956
27Lysosome_Homo sapiens_hsa041421.24478303
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23455652
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22887267
30Acute myeloid leukemia_Homo sapiens_hsa052211.21828606
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21580765
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20732112
33Gap junction_Homo sapiens_hsa045401.19825674
34Oxytocin signaling pathway_Homo sapiens_hsa049211.18972552
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17682111
36Malaria_Homo sapiens_hsa051441.17376476
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14094347
38Leishmaniasis_Homo sapiens_hsa051401.13631261
39Gastric acid secretion_Homo sapiens_hsa049711.13298276
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08993884
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08861009
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08848410
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08606867
44Estrogen signaling pathway_Homo sapiens_hsa049151.07770656
45Proteoglycans in cancer_Homo sapiens_hsa052051.07215638
46Tuberculosis_Homo sapiens_hsa051521.07097993
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06116516
48Salmonella infection_Homo sapiens_hsa051321.05428884
49Toxoplasmosis_Homo sapiens_hsa051451.05240151
50Cardiac muscle contraction_Homo sapiens_hsa042601.04555476
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04234370
52Amoebiasis_Homo sapiens_hsa051461.03476199
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03405394
54Olfactory transduction_Homo sapiens_hsa047401.02783847
55Phagosome_Homo sapiens_hsa041450.99236011
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.99203846
57Pancreatic cancer_Homo sapiens_hsa052120.99072930
58Rap1 signaling pathway_Homo sapiens_hsa040150.99022760
59HIF-1 signaling pathway_Homo sapiens_hsa040660.97878321
60TNF signaling pathway_Homo sapiens_hsa046680.97842473
61N-Glycan biosynthesis_Homo sapiens_hsa005100.97406572
62Pertussis_Homo sapiens_hsa051330.97406167
63Bladder cancer_Homo sapiens_hsa052190.96640885
64Renin-angiotensin system_Homo sapiens_hsa046140.96411565
65GnRH signaling pathway_Homo sapiens_hsa049120.96286462
66Renal cell carcinoma_Homo sapiens_hsa052110.92931868
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92770519
68Insulin signaling pathway_Homo sapiens_hsa049100.92733109
69Shigellosis_Homo sapiens_hsa051310.92587381
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92393008
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91913674
72Salivary secretion_Homo sapiens_hsa049700.91379787
73B cell receptor signaling pathway_Homo sapiens_hsa046620.88772191
74Insulin secretion_Homo sapiens_hsa049110.88181508
75Calcium signaling pathway_Homo sapiens_hsa040200.88014618
76cAMP signaling pathway_Homo sapiens_hsa040240.87977237
77Endometrial cancer_Homo sapiens_hsa052130.87704427
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.87530850
79Oocyte meiosis_Homo sapiens_hsa041140.87486403
80DNA replication_Homo sapiens_hsa030300.85985393
81Dorso-ventral axis formation_Homo sapiens_hsa043200.85679293
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85674701
83Morphine addiction_Homo sapiens_hsa050320.85316233
84Viral myocarditis_Homo sapiens_hsa054160.84743732
85Dopaminergic synapse_Homo sapiens_hsa047280.83501257
86Cholinergic synapse_Homo sapiens_hsa047250.83399810
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82972642
88Chemokine signaling pathway_Homo sapiens_hsa040620.82769390
89Renin secretion_Homo sapiens_hsa049240.82307013
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.81810770
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81757529
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81568271
93Synaptic vesicle cycle_Homo sapiens_hsa047210.81350942
94Colorectal cancer_Homo sapiens_hsa052100.81248916
95Vibrio cholerae infection_Homo sapiens_hsa051100.77929359
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77799663
97Thyroid cancer_Homo sapiens_hsa052160.77436893
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.77045597
99Staphylococcus aureus infection_Homo sapiens_hsa051500.76453131
100Amphetamine addiction_Homo sapiens_hsa050310.75634395
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74140921
102Endocytosis_Homo sapiens_hsa041440.73762097
103ErbB signaling pathway_Homo sapiens_hsa040120.73661222
104MicroRNAs in cancer_Homo sapiens_hsa052060.72423757
105Axon guidance_Homo sapiens_hsa043600.72088021
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71976424
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.71344009
108Prolactin signaling pathway_Homo sapiens_hsa049170.71140083
109Hepatitis C_Homo sapiens_hsa051600.70969452
110Glutamatergic synapse_Homo sapiens_hsa047240.70937956
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.70843397
112Notch signaling pathway_Homo sapiens_hsa043300.70736911
113Influenza A_Homo sapiens_hsa051640.69750494
114Apoptosis_Homo sapiens_hsa042100.68978607
115Glucagon signaling pathway_Homo sapiens_hsa049220.68315185
116Cell cycle_Homo sapiens_hsa041100.68019635
117Pathways in cancer_Homo sapiens_hsa052000.67215645
118Insulin resistance_Homo sapiens_hsa049310.66786288
119MAPK signaling pathway_Homo sapiens_hsa040100.66500026
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66198131
121Adherens junction_Homo sapiens_hsa045200.65434288
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.64774641
123Cocaine addiction_Homo sapiens_hsa050300.64590120
124HTLV-I infection_Homo sapiens_hsa051660.64426459
125Melanogenesis_Homo sapiens_hsa049160.64221772
126Inositol phosphate metabolism_Homo sapiens_hsa005620.64156510
127Type II diabetes mellitus_Homo sapiens_hsa049300.64101576
128Hepatitis B_Homo sapiens_hsa051610.63115126
129Choline metabolism in cancer_Homo sapiens_hsa052310.62373048
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61735409
131FoxO signaling pathway_Homo sapiens_hsa040680.59335039
132Ras signaling pathway_Homo sapiens_hsa040140.58562826
133AMPK signaling pathway_Homo sapiens_hsa041520.57769568
134GABAergic synapse_Homo sapiens_hsa047270.57660791

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