FAM65C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)9.47793959
2gas transport (GO:0015669)8.72995395
3porphyrin-containing compound biosynthetic process (GO:0006779)7.65838749
4negative regulation of erythrocyte differentiation (GO:0045647)7.41149791
5hemoglobin metabolic process (GO:0020027)7.23902942
6erythrocyte maturation (GO:0043249)6.86657827
7tetrapyrrole biosynthetic process (GO:0033014)6.74588081
8erythrocyte development (GO:0048821)6.58963204
9heme biosynthetic process (GO:0006783)6.58686510
10definitive hemopoiesis (GO:0060216)6.53221878
11porphyrin-containing compound metabolic process (GO:0006778)6.30893368
12vitamin transmembrane transport (GO:0035461)6.20010874
13establishment of skin barrier (GO:0061436)6.07152273
14keratinization (GO:0031424)5.92299367
15regulation of water loss via skin (GO:0033561)5.53151142
16regulation of response to osmotic stress (GO:0047484)5.36920865
17heme metabolic process (GO:0042168)5.30040243
18granulocyte differentiation (GO:0030851)5.11438937
19desmosome organization (GO:0002934)4.99314235
20myeloid cell development (GO:0061515)4.90931122
21epoxygenase P450 pathway (GO:0019373)4.88570990
22regulation of erythrocyte differentiation (GO:0045646)4.71729821
23iron ion import (GO:0097286)4.65659427
24skin morphogenesis (GO:0043589)4.65133254
25urate metabolic process (GO:0046415)4.54385044
26lung-associated mesenchyme development (GO:0060484)4.40488701
27pantothenate metabolic process (GO:0015939)4.30551688
28serine family amino acid catabolic process (GO:0009071)4.28790671
29regulation of natural killer cell differentiation (GO:0032823)4.22868313
30positive regulation of natural killer cell differentiation (GO:0032825)4.19287903
31megakaryocyte development (GO:0035855)4.08633742
32positive regulation of erythrocyte differentiation (GO:0045648)3.96777847
33antibacterial humoral response (GO:0019731)3.95410542
34thrombin receptor signaling pathway (GO:0070493)3.94673609
35mannose metabolic process (GO:0006013)3.83368343
36valine metabolic process (GO:0006573)3.78579433
37tetrapyrrole metabolic process (GO:0033013)3.78092544
38glycine metabolic process (GO:0006544)3.77194739
39biotin metabolic process (GO:0006768)3.75468943
40antimicrobial humoral response (GO:0019730)3.72982084
41positive regulation of B cell differentiation (GO:0045579)3.67292880
42regulation of cholesterol homeostasis (GO:2000188)3.66392277
43omega-hydroxylase P450 pathway (GO:0097267)3.56979841
44vitamin transport (GO:0051180)3.55451178
45response to peptidoglycan (GO:0032494)3.55006210
46embryonic hemopoiesis (GO:0035162)3.54795701
47blood vessel maturation (GO:0001955)3.50991620
48folic acid metabolic process (GO:0046655)3.49453454
49Peyers patch development (GO:0048541)3.48616723
50mucosal-associated lymphoid tissue development (GO:0048537)3.48616723
51defense response to fungus (GO:0050832)3.46738078
52endothelial cell chemotaxis (GO:0035767)3.43781694
53disruption of cells of other organism (GO:0044364)3.42026715
54killing of cells of other organism (GO:0031640)3.42026715
55regulation of female gonad development (GO:2000194)3.41582721
56one-carbon compound transport (GO:0019755)3.41279804
57innate immune response in mucosa (GO:0002227)3.36167025
58phospholipid efflux (GO:0033700)3.35331042
59epithelial cell-cell adhesion (GO:0090136)3.34727141
60multicellular organismal water homeostasis (GO:0050891)3.33674381
61JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32606058
62erythrocyte differentiation (GO:0030218)3.30897048
63folic acid transport (GO:0015884)3.30462459
64platelet formation (GO:0030220)3.29755712
65response to methylmercury (GO:0051597)3.27944486
66purine nucleobase biosynthetic process (GO:0009113)3.27377922
67tryptophan metabolic process (GO:0006568)3.26255022
68molting cycle (GO:0042303)3.23237061
69hair cycle (GO:0042633)3.23237061
70cysteine metabolic process (GO:0006534)3.23103254
71regulation of protein activation cascade (GO:2000257)3.21655179
72water homeostasis (GO:0030104)3.20473475
73kynurenine metabolic process (GO:0070189)3.18602129
74modified amino acid transport (GO:0072337)3.17990156
75positive regulation of granulocyte differentiation (GO:0030854)3.15879061
76regulation of complement activation (GO:0030449)3.14896219
77serine family amino acid metabolic process (GO:0009069)3.13683112
78platelet aggregation (GO:0070527)3.11483105
79protein carboxylation (GO:0018214)3.11473357
80peptidyl-glutamic acid carboxylation (GO:0017187)3.11473357
81mesodermal cell differentiation (GO:0048333)3.08976392
82regulation of transforming growth factor beta1 production (GO:0032908)3.08613566
83positive regulation of gamma-delta T cell activation (GO:0046645)3.08042102
84negative regulation of bone mineralization (GO:0030502)3.07570414
85negative regulation of biomineral tissue development (GO:0070168)3.06249397
86regulation of mast cell degranulation (GO:0043304)3.05656551
87tryptophan catabolic process (GO:0006569)3.05601032
88indole-containing compound catabolic process (GO:0042436)3.05601032
89indolalkylamine catabolic process (GO:0046218)3.05601032
90amino-acid betaine metabolic process (GO:0006577)3.04135306
91collagen fibril organization (GO:0030199)3.02357862
92positive regulation of megakaryocyte differentiation (GO:0045654)3.02326604
93creatine metabolic process (GO:0006600)2.99879072
94negative regulation of macrophage differentiation (GO:0045650)2.98949589
95endocardial cushion development (GO:0003197)2.98588180
96potassium ion export (GO:0071435)2.95461275
97cellular response to thyroid hormone stimulus (GO:0097067)2.95136201
98endothelium development (GO:0003158)2.94164534
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.93978961
100L-phenylalanine catabolic process (GO:0006559)2.93978961
101positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.90855199
102regulation of integrin activation (GO:0033623)2.90702311
103glycine transport (GO:0015816)2.89396394
104aromatic amino acid family catabolic process (GO:0009074)2.87762151
105protein heterotrimerization (GO:0070208)2.86246789
106negative regulation of viral entry into host cell (GO:0046597)2.84158348
107positive regulation of glomerulus development (GO:0090193)2.83942986
108regulation of mast cell activation involved in immune response (GO:0033006)2.83811196
109linoleic acid metabolic process (GO:0043651)2.83217250
110regulation of spindle organization (GO:0090224)2.81495331
111S-adenosylmethionine metabolic process (GO:0046500)2.81256191
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80233108
113L-phenylalanine metabolic process (GO:0006558)2.80233108
114extracellular fibril organization (GO:0043206)2.79323452
115fibril organization (GO:0097435)2.79130456
116regulation of G0 to G1 transition (GO:0070316)2.77647495
117positive regulation of extracellular matrix organization (GO:1903055)2.77580089
118regulation of gamma-delta T cell differentiation (GO:0045586)2.76212106
119collagen metabolic process (GO:0032963)2.75326907
120fibrinolysis (GO:0042730)2.75138197
121positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.73614734
122collagen catabolic process (GO:0030574)2.71090238
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70694844
124homocysteine metabolic process (GO:0050667)2.70097555
125negative regulation of fibrinolysis (GO:0051918)2.69935104
126complement activation, alternative pathway (GO:0006957)2.69306682
127positive regulation of cholesterol efflux (GO:0010875)2.69002414
128mucosal immune response (GO:0002385)2.68806276
129hemopoiesis (GO:0030097)2.65959901
130positive regulation of sterol transport (GO:0032373)2.65427877
131positive regulation of cholesterol transport (GO:0032376)2.65427877
132retinal metabolic process (GO:0042574)2.63093549
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62704825
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62520387
135regulation of fibrinolysis (GO:0051917)2.62458296
136basement membrane organization (GO:0071711)2.62257039
137G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61714234
138positive regulation of osteoblast proliferation (GO:0033690)2.61082993
139keratinocyte differentiation (GO:0030216)2.59452870
140nucleobase biosynthetic process (GO:0046112)2.58770246
141type B pancreatic cell proliferation (GO:0044342)2.58755989
142hydrogen peroxide catabolic process (GO:0042744)2.58639470
143response to mercury ion (GO:0046689)2.58333134
144hematopoietic stem cell differentiation (GO:0060218)2.58057372
145regulation of chemokine biosynthetic process (GO:0045073)2.57635252
146hemidesmosome assembly (GO:0031581)2.57509982
147organ or tissue specific immune response (GO:0002251)2.57437485
148regulation of natural killer cell activation (GO:0032814)2.56834190
149NAD biosynthetic process (GO:0009435)2.56450831
150multicellular organismal macromolecule metabolic process (GO:0044259)2.54951114
151endodermal cell differentiation (GO:0035987)2.54889511
152UV protection (GO:0009650)2.54233694
153ectoderm development (GO:0007398)2.53714052
154positive regulation of natural killer cell activation (GO:0032816)2.52536516
155aromatic amino acid family metabolic process (GO:0009072)2.52449503
156peptide cross-linking (GO:0018149)2.52343684
157regulation of hypersensitivity (GO:0002883)2.52316930
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.52261091
159pyrimidine-containing compound transmembrane transport (GO:0072531)2.51875694
160negative regulation of Ras GTPase activity (GO:0034261)2.50756361
161intestinal epithelial cell development (GO:0060576)2.50547948
162blood circulation (GO:0008015)2.49898929
163regulation of platelet aggregation (GO:0090330)2.49849083
164glyoxylate metabolic process (GO:0046487)2.49733906
165multicellular organismal catabolic process (GO:0044243)2.49604547
166regulation of mitotic spindle organization (GO:0060236)2.48414774
167regulation of cell proliferation involved in kidney development (GO:1901722)2.48346680
168serine family amino acid biosynthetic process (GO:0009070)2.47033407
169response to thyroid hormone (GO:0097066)2.45663598
170cofactor transport (GO:0051181)2.45157179
171cellular extravasation (GO:0045123)2.44917801
172multicellular organismal metabolic process (GO:0044236)2.43681434
173ribosome assembly (GO:0042255)2.42723136
174positive regulation of male gonad development (GO:2000020)2.42496713
175intermediate filament organization (GO:0045109)2.42405982
176regulation of plasminogen activation (GO:0010755)2.42202634
177cardiolipin metabolic process (GO:0032048)2.41151258
178positive regulation of vasculogenesis (GO:2001214)2.39450914
179positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.38884111
180response to fungus (GO:0009620)2.38811610
181negative regulation of interleukin-8 production (GO:0032717)2.38445837
182establishment of planar polarity (GO:0001736)2.37441469
183establishment of tissue polarity (GO:0007164)2.37441469
184response to arsenic-containing substance (GO:0046685)2.37122326
185regulation of histone H3-K4 methylation (GO:0051569)2.36696888
186regulation of platelet activation (GO:0010543)2.36241745
187positive regulation of steroid metabolic process (GO:0045940)2.36013087
188response to lead ion (GO:0010288)2.35970387
189ovulation from ovarian follicle (GO:0001542)2.35864053
190hippo signaling (GO:0035329)2.35550903
191regulation of viral entry into host cell (GO:0046596)2.35390371
192hyaluronan catabolic process (GO:0030214)2.34632527
193intracellular estrogen receptor signaling pathway (GO:0030520)2.34199247
194regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33525781
195alditol metabolic process (GO:0019400)2.32888255
196wound healing, spreading of cells (GO:0044319)2.32663499
197urea cycle (GO:0000050)2.31594009
198positive regulation of protein kinase C signaling (GO:0090037)2.30364044
199protoporphyrinogen IX metabolic process (GO:0046501)11.5522642
200protoporphyrinogen IX biosynthetic process (GO:0006782)10.6349154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.06542833
2SCL_19346495_ChIP-Seq_HPC-7_Human5.07535197
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.63813047
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.09562175
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.65221759
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.30435368
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07091834
8GATA1_19941827_ChIP-Seq_MEL_Mouse3.04587471
9ZNF263_19887448_ChIP-Seq_K562_Human2.92798279
10TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.83861540
11CLOCK_20551151_ChIP-Seq_293T_Human2.75292974
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.73621960
13SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.70630211
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66820439
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.53391020
16* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.52941833
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50959420
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.44080484
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38813096
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.26275184
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25522508
22* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.22270985
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20957655
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09387644
25VDR_21846776_ChIP-Seq_THP-1_Human2.02551274
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98656933
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98253971
28SPI1_23127762_ChIP-Seq_K562_Human1.97124667
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.97112714
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95312529
31* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.93935564
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.91751651
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90906775
34E2F7_22180533_ChIP-Seq_HELA_Human1.89822124
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.89675520
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.89617841
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89050452
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.87843569
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86328641
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.84533328
41VDR_24763502_ChIP-Seq_THP-1_Human1.83287756
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82457538
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80834805
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78381583
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77763476
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.76488911
47KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.72861606
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68190915
49MAF_26560356_Chip-Seq_TH1_Human1.67442235
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65542163
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.64922402
52ATF3_27146783_Chip-Seq_COLON_Human1.64908257
53RACK7_27058665_Chip-Seq_MCF-7_Human1.63520874
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62205928
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61954578
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61058533
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.56323594
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55552756
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54139817
60AR_21909140_ChIP-Seq_LNCAP_Human1.52130176
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.51870906
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51322504
63BCL6_27268052_Chip-Seq_Bcells_Human1.48830884
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47947374
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44787127
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44143979
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.43025567
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41752422
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39781178
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39338298
71STAT1_20625510_ChIP-Seq_HELA_Human1.39110047
72GATA1_22025678_ChIP-Seq_K562_Human1.36903809
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35682703
74* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34584846
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33472925
76UTX_26944678_Chip-Seq_JUKART_Human1.33450625
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32782446
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31787309
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29454446
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27351289
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27102852
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25408740
83MYC_22102868_ChIP-Seq_BL_Human1.24212003
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.23956599
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23456204
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21394029
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20742376
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19786644
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19543528
90LXR_22292898_ChIP-Seq_THP-1_Human1.18389257
91MAF_26560356_Chip-Seq_TH2_Human1.17728340
92KDM2B_26808549_Chip-Seq_DND41_Human1.17154076
93* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16563691
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.16377506
95GATA1_19941826_ChIP-Seq_K562_Human1.16072984
96BCOR_27268052_Chip-Seq_Bcells_Human1.15732328
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15535423
98* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13502685
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12483471
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12242494
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09883350
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08234666
103P300_27268052_Chip-Seq_Bcells_Human1.05790673
104P68_20966046_ChIP-Seq_HELA_Human1.05773434
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04661436
106* GATA4_25053715_ChIP-Seq_YYC3_Human1.03756159
107GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03732238
108* FOXO3_23340844_ChIP-Seq_DLD1_Human1.02398857
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.99341845
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99334787
111* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98113226
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97018674
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97018674
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97018674
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95836130
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95692697
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95639536
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95139766
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95139766
120KDM2B_26808549_Chip-Seq_K562_Human0.94905198
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94841266
122CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94154794
123GATA2_19941826_ChIP-Seq_K562_Human0.92749356
124SA1_27219007_Chip-Seq_Bcells_Human0.92378147
125SPI1_20517297_ChIP-Seq_HL60_Human0.92319815
126STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92096347
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91903498
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91680507
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91451547
130TP63_22573176_ChIP-Seq_HFKS_Human0.91403428
131TCF7_22412390_ChIP-Seq_EML_Mouse0.91281486
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91122442
133PHF8_20622854_ChIP-Seq_HELA_Human0.90891196
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90635046
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90617470
136* CTCF_21964334_Chip-Seq_Bcells_Human0.89940450
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89832415
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89160500
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88966496
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.88942014
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88909981
142CREB1_26743006_Chip-Seq_LNCaP_Human0.88679813
143MYB_26560356_Chip-Seq_TH1_Human0.88517621
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.88097199
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87986415
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87134140
147NCOR1_26117541_ChIP-Seq_K562_Human0.87093587
148E2F1_20622854_ChIP-Seq_HELA_Human0.86859962
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86672804
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85586131
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84956017
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83030562
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82794211
154CTCF_27219007_Chip-Seq_Bcells_Human0.81319454
155* YY1_22570637_ChIP-Seq_MALME-3M_Human0.80774703
156MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80635794
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.79038492
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78281751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.99320690
2MP0005275_abnormal_skin_tensile5.42126947
3MP0002796_impaired_skin_barrier4.23071027
4MP0009278_abnormal_bone_marrow3.69932182
5MP0003705_abnormal_hypodermis_morpholog3.66418230
6MP0008438_abnormal_cutaneous_collagen3.65900168
7MP0003303_peritoneal_inflammation3.63712028
8MP0005451_abnormal_body_composition3.37683642
9MP0010234_abnormal_vibrissa_follicle3.03252605
10MP0002060_abnormal_skin_morphology2.82207701
11MP0005360_urolithiasis2.77315302
12MP0009840_abnormal_foam_cell2.74803854
13MP0002139_abnormal_hepatobiliary_system2.70155297
14MP0003941_abnormal_skin_development2.69921065
15MP0005501_abnormal_skin_physiology2.54780568
16MP0003191_abnormal_cellular_cholesterol2.35484803
17MP0008995_early_reproductive_senescence2.09341829
18MP0005365_abnormal_bile_salt1.99067750
19MP0000383_abnormal_hair_follicle1.96942768
20MP0003436_decreased_susceptibility_to1.96915905
21MP0005503_abnormal_tendon_morphology1.94329031
22MP0005085_abnormal_gallbladder_physiolo1.88056569
23MP0004381_abnormal_hair_follicle1.85789336
24MP0000647_abnormal_sebaceous_gland1.82665466
25MP0004947_skin_inflammation1.82517336
26MP0010678_abnormal_skin_adnexa1.82174266
27MP0001216_abnormal_epidermal_layer1.80414127
28MP0004808_abnormal_hematopoietic_stem1.79661245
29MP0010771_integument_phenotype1.74375097
30MP0001243_abnormal_dermal_layer1.71381477
31MP0000579_abnormal_nail_morphology1.69700188
32MP0001986_abnormal_taste_sensitivity1.68619968
33MP0002098_abnormal_vibrissa_morphology1.66651035
34MP0003724_increased_susceptibility_to1.64414312
35MP0003195_calcinosis1.62870088
36MP0005636_abnormal_mineral_homeostasis1.48723900
37MP0008004_abnormal_stomach_pH1.46829380
38MP0001542_abnormal_bone_strength1.45750548
39MP0004019_abnormal_vitamin_homeostasis1.44441550
40MP0000377_abnormal_hair_follicle1.43254027
41MP0003252_abnormal_bile_duct1.41148798
42MP0000465_gastrointestinal_hemorrhage1.40901722
43MP0005257_abnormal_intraocular_pressure1.39533714
44MP0003453_abnormal_keratinocyte_physiol1.33053704
45MP0005332_abnormal_amino_acid1.27692089
46MP0009931_abnormal_skin_appearance1.25845040
47MP0009764_decreased_sensitivity_to1.25150230
48MP0003186_abnormal_redox_activity1.23832943
49MP0000750_abnormal_muscle_regeneration1.22405462
50MP0003718_maternal_effect1.22315682
51MP0003172_abnormal_lysosome_physiology1.20838302
52MP0001533_abnormal_skeleton_physiology1.19632963
53MP0003566_abnormal_cell_adhesion1.17859734
54MP0005076_abnormal_cell_differentiation1.17528712
55MP0003567_abnormal_fetal_cardiomyocyte1.14558149
56MP0010329_abnormal_lipoprotein_level1.14210363
57MP0008875_abnormal_xenobiotic_pharmacok1.12748645
58MP0002396_abnormal_hematopoietic_system1.10022569
59MP0003828_pulmonary_edema1.08189414
60MP0005025_abnormal_response_to1.08109671
61MP0002254_reproductive_system_inflammat1.08109143
62MP0009333_abnormal_splenocyte_physiolog1.07733063
63MP0004130_abnormal_muscle_cell1.07689925
64MP0005508_abnormal_skeleton_morphology1.04447864
65MP0002419_abnormal_innate_immunity1.04080625
66MP0003656_abnormal_erythrocyte_physiolo1.03413741
67MP0000367_abnormal_coat/_hair1.03170496
68MP0001191_abnormal_skin_condition1.02405950
69MP0001756_abnormal_urination1.02144660
70MP0002398_abnormal_bone_marrow1.01990327
71MP0000689_abnormal_spleen_morphology1.01474597
72MP0005410_abnormal_fertilization1.00734221
73MP0000609_abnormal_liver_physiology1.00716924
74MP0002132_abnormal_respiratory_system1.00491662
75MP0005058_abnormal_lysosome_morphology1.00223267
76MP0002332_abnormal_exercise_endurance0.99277313
77MP0004272_abnormal_basement_membrane0.98355731
78MP0009053_abnormal_anal_canal0.97126368
79MP0009384_cardiac_valve_regurgitation0.96976241
80MP0004145_abnormal_muscle_electrophysio0.96723777
81MP0002722_abnormal_immune_system0.96446002
82MP0004185_abnormal_adipocyte_glucose0.96370421
83MP0006054_spinal_hemorrhage0.95847607
84MP0006036_abnormal_mitochondrial_physio0.95584589
85MP0003878_abnormal_ear_physiology0.94861831
86MP0005377_hearing/vestibular/ear_phenot0.94861831
87MP0004264_abnormal_extraembryonic_tissu0.90582216
88MP0005595_abnormal_vascular_smooth0.90333906
89MP0001958_emphysema0.90277905
90MP0005164_abnormal_response_to0.89763186
91MP0005023_abnormal_wound_healing0.88400404
92MP0002163_abnormal_gland_morphology0.88385368
93MP0009643_abnormal_urine_homeostasis0.88005393
94MP0001661_extended_life_span0.86166796
95MP0000343_altered_response_to0.84194260
96MP0003693_abnormal_embryo_hatching0.83496340
97MP0002429_abnormal_blood_cell0.82817400
98MP0005647_abnormal_sex_gland0.82752193
99MP0005670_abnormal_white_adipose0.82664008
100MP0002295_abnormal_pulmonary_circulatio0.80662833
101MP0003385_abnormal_body_wall0.80554177
102MP0003300_gastrointestinal_ulcer0.79864484
103MP0003806_abnormal_nucleotide_metabolis0.79163929
104MP0003279_aneurysm0.78571230
105MP0010352_gastrointestinal_tract_polyps0.78122857
106MP0000230_abnormal_systemic_arterial0.76485210
107MP0002136_abnormal_kidney_physiology0.75817816
108MP0002166_altered_tumor_susceptibility0.75709527
109MP0009672_abnormal_birth_weight0.75561410
110MP0000751_myopathy0.74397432
111MP0005319_abnormal_enzyme/_coenzyme0.74318558
112MP0005000_abnormal_immune_tolerance0.73423346
113MP0001666_abnormal_nutrient_absorption0.73135438
114MP0009763_increased_sensitivity_to0.72908129
115MP0005395_other_phenotype0.71782320
116MP0001664_abnormal_digestion0.70865086
117MP0000372_irregular_coat_pigmentation0.70837229
118MP0005535_abnormal_body_temperature0.70750220
119MP0002138_abnormal_hepatobiliary_system0.70747524
120MP0009785_altered_susceptibility_to0.70744072
121MP0002111_abnormal_tail_morphology0.70485000
122MP0006138_congestive_heart_failure0.69344508
123MP0002006_tumorigenesis0.69119847
124MP0000767_abnormal_smooth_muscle0.68192146
125MP0000762_abnormal_tongue_morphology0.68174627
126MP0005464_abnormal_platelet_physiology0.67035285
127MP0002877_abnormal_melanocyte_morpholog0.66669173
128MP0001663_abnormal_digestive_system0.66585989
129MP0004197_abnormal_fetal_growth/weight/0.65447110
130MP0008874_decreased_physiological_sensi0.63854988
131MP0010307_abnormal_tumor_latency0.63624094
132MP0003123_paternal_imprinting0.63345713
133MP0010030_abnormal_orbit_morphology0.63067845
134MP0001835_abnormal_antigen_presentation0.62460286
135MP0005376_homeostasis/metabolism_phenot0.62125277
136MP0001881_abnormal_mammary_gland0.61389933
137MP0002405_respiratory_system_inflammati0.61076677
138MP0002148_abnormal_hypersensitivity_rea0.60916435
139MP0005266_abnormal_metabolism0.60864877
140MP0000733_abnormal_muscle_development0.60485051
141MP0002118_abnormal_lipid_homeostasis0.60168381
142MP0009765_abnormal_xenobiotic_induced0.59356965
143MP0005390_skeleton_phenotype0.59105596
144MP0004036_abnormal_muscle_relaxation0.58840133
145MP0002128_abnormal_blood_circulation0.58492235
146MP0001764_abnormal_homeostasis0.58435518
147MP0002019_abnormal_tumor_incidence0.57918720
148MP0005666_abnormal_adipose_tissue0.57905176
149MP0005397_hematopoietic_system_phenotyp0.57717198
150MP0001545_abnormal_hematopoietic_system0.57717198
151MP0003045_fibrosis0.57101590
152MP0000249_abnormal_blood_vessel0.56320588
153MP0000534_abnormal_ureter_morphology0.56082352
154MP0001784_abnormal_fluid_regulation0.55695754
155MP0002971_abnormal_brown_adipose0.55383704
156MP0005334_abnormal_fat_pad0.55310275
157MP0005187_abnormal_penis_morphology0.54818254
158MP0002420_abnormal_adaptive_immunity0.54646353
159MP0008775_abnormal_heart_ventricle0.54429344
160MP0005083_abnormal_biliary_tract0.54110527
161MP0000598_abnormal_liver_morphology0.53692659
162MP0002933_joint_inflammation0.53247443
163MP0001340_abnormal_eyelid_morphology0.52809462

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.37309692
2Reticulocytosis (HP:0001923)6.49644793
3Premature rupture of membranes (HP:0001788)5.55275721
4Abnormal hemoglobin (HP:0011902)5.26828612
5Prolonged bleeding time (HP:0003010)4.83624954
6Acanthocytosis (HP:0001927)4.30663971
7Hypochromic microcytic anemia (HP:0004840)4.29109746
8Petechiae (HP:0000967)4.28974120
9Cholelithiasis (HP:0001081)4.21491146
10Abnormal gallbladder physiology (HP:0012438)4.17194649
11Cholecystitis (HP:0001082)4.17194649
12Abnormality of reticulocytes (HP:0004312)4.15756810
13Microcytic anemia (HP:0001935)4.11920985
14Follicular hyperkeratosis (HP:0007502)4.10963100
15Soft skin (HP:0000977)4.07727627
16Abnormality of iron homeostasis (HP:0011031)3.93304735
17Alopecia of scalp (HP:0002293)3.81042126
18Hypochromic anemia (HP:0001931)3.80795792
19Hypotrichosis (HP:0001006)3.79683121
20Epistaxis (HP:0000421)3.79196855
21Hypertensive crisis (HP:0100735)3.75506209
22Increased IgE level (HP:0003212)3.75433789
23Abnormality of transition element cation homeostasis (HP:0011030)3.74733259
24Abnormal gallbladder morphology (HP:0012437)3.69115665
25Paralysis (HP:0003470)3.63864651
26Protrusio acetabuli (HP:0003179)3.61973962
27Increased mean platelet volume (HP:0011877)3.58381965
28Increased serum ferritin (HP:0003281)3.54479170
29Ileus (HP:0002595)3.53797466
30Impaired platelet aggregation (HP:0003540)3.53253276
31Abnormal platelet function (HP:0011869)3.53253276
32Hyperglycinuria (HP:0003108)3.45896334
33Abnormal number of erythroid precursors (HP:0012131)3.45011195
34Pustule (HP:0200039)3.42624342
35Gout (HP:0001997)3.38622810
36Hyperglycinemia (HP:0002154)3.36660238
37Hyperthyroidism (HP:0000836)3.36455024
38Abnormal platelet volume (HP:0011876)3.32390838
39Congenital ichthyosiform erythroderma (HP:0007431)3.31286956
40Menorrhagia (HP:0000132)3.25896496
41Osteolytic defects of the phalanges of the hand (HP:0009771)3.18147241
42Osteolytic defects of the hand bones (HP:0009699)3.18147241
43Abnormality of nail color (HP:0100643)3.10047513
44Ankle contracture (HP:0006466)3.09546876
45Muscle fiber splitting (HP:0003555)3.06254776
46Increased connective tissue (HP:0009025)3.06144384
47Xanthomatosis (HP:0000991)2.98271074
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.98025617
49Hyperbilirubinemia (HP:0002904)2.95472382
50Abnormality of the gallbladder (HP:0005264)2.90939389
51Gonadal dysgenesis (HP:0000133)2.90726345
52Abnormality of cells of the erythroid lineage (HP:0012130)2.89601187
53Atelectasis (HP:0100750)2.89337132
54Woolly hair (HP:0002224)2.83720700
55Atrophic scars (HP:0001075)2.80706676
56Truncus arteriosus (HP:0001660)2.80249069
57Areflexia of lower limbs (HP:0002522)2.79294250
58Myocardial infarction (HP:0001658)2.74454717
59Shallow orbits (HP:0000586)2.67003098
60Abnormality of the fingertips (HP:0001211)2.65700241
61Gingival bleeding (HP:0000225)2.65482001
62Corneal erosion (HP:0200020)2.65198271
63Onycholysis (HP:0001806)2.64449978
64Pili torti (HP:0003777)2.63130857
65Concave nail (HP:0001598)2.62702330
66Abnormality of serine family amino acid metabolism (HP:0010894)2.62384089
67Abnormality of glycine metabolism (HP:0010895)2.62384089
68Abnormality of the Achilles tendon (HP:0005109)2.61166658
69Deep venous thrombosis (HP:0002625)2.60326804
70Atrioventricular block (HP:0001678)2.59707416
71Purpura (HP:0000979)2.59368298
72Testicular neoplasm (HP:0010788)2.53803577
73Pallor (HP:0000980)2.53507612
74Brittle hair (HP:0002299)2.50840944
75Peritonitis (HP:0002586)2.50364338
76Diaphragmatic weakness (HP:0009113)2.50042707
77Polycythemia (HP:0001901)2.49039412
78Biconcave vertebral bodies (HP:0004586)2.48773261
79Seborrheic dermatitis (HP:0001051)2.48622278
80Achilles tendon contracture (HP:0001771)2.47832501
81Bladder diverticulum (HP:0000015)2.44296368
82Natal tooth (HP:0000695)2.39391711
83Fragile skin (HP:0001030)2.38313930
84Erythroderma (HP:0001019)2.37938995
85Hypoparathyroidism (HP:0000829)2.37567059
86Obstructive lung disease (HP:0006536)2.37412801
87Chronic obstructive pulmonary disease (HP:0006510)2.37412801
88Aortic aneurysm (HP:0004942)2.37024488
89Right ventricular cardiomyopathy (HP:0011663)2.33719386
90Cerebral palsy (HP:0100021)2.33703400
91Genu recurvatum (HP:0002816)2.31334919
92Congenital, generalized hypertrichosis (HP:0004540)2.29162539
93Tetraplegia (HP:0002445)2.25553917
94Abnormal delivery (HP:0001787)2.25097928
95Thick nail (HP:0001805)2.24448356
96Asymmetry of the thorax (HP:0001555)2.23845649
97Abnormality of the umbilical cord (HP:0010881)2.23380957
98Mesangial abnormality (HP:0001966)2.23199663
99Gastrointestinal infarctions (HP:0005244)2.23183922
100Hyperlipoproteinemia (HP:0010980)2.21748360
101Nonimmune hydrops fetalis (HP:0001790)2.20757408
102Type 1 muscle fiber predominance (HP:0003803)2.20545825
103Palmoplantar hyperkeratosis (HP:0000972)2.18175030
104Bruising susceptibility (HP:0000978)2.18136647
105Difficulty climbing stairs (HP:0003551)2.17909035
106Abnormality of the distal phalanges of the toes (HP:0010182)2.17279741
107Mitral valve prolapse (HP:0001634)2.17177102
108Lack of skin elasticity (HP:0100679)2.16791173
109Thin bony cortex (HP:0002753)2.15326977
110Dilatation of the ascending aorta (HP:0005111)2.14586235
111Broad metatarsal (HP:0001783)2.12707689
112Sparse eyelashes (HP:0000653)2.12328240
113Plantar hyperkeratosis (HP:0007556)2.09486310
114Anhidrosis (HP:0000970)2.07727586
115Delayed epiphyseal ossification (HP:0002663)2.07692355
116Complement deficiency (HP:0004431)2.05571804
117Cerebral aneurysm (HP:0004944)2.04615007
118Palmar hyperkeratosis (HP:0010765)2.03371294
119Entropion (HP:0000621)2.00909197
120Bowel incontinence (HP:0002607)2.00688220
121Abnormality of the heme biosynthetic pathway (HP:0010472)10.9086626
122Cardiovascular calcification (HP:0011915)1.99900703
123Advanced eruption of teeth (HP:0006288)1.99561471
124Albinism (HP:0001022)1.97936035
125Confusion (HP:0001289)1.97284644
126Milia (HP:0001056)1.96390082
127Rectal prolapse (HP:0002035)1.95596556
128Fragile nails (HP:0001808)1.92748347
129Gastrointestinal dysmotility (HP:0002579)1.91242387
130Abnormal large intestine physiology (HP:0012700)1.90926072
131Abnormality of skeletal muscle fiber size (HP:0012084)1.90272914
132Cutaneous photosensitivity (HP:0000992)1.89701493
133Hyporeflexia of lower limbs (HP:0002600)1.88830086
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88647907
135Abnormality of the pulmonary veins (HP:0011718)1.87228035
136Increased purine levels (HP:0004368)1.85685373
137Hyperuricemia (HP:0002149)1.85685373
138Aortic dissection (HP:0002647)1.84891063
139Hypoalphalipoproteinemia (HP:0003233)1.84139600
140Nephritis (HP:0000123)1.83379614
141Venous insufficiency (HP:0005293)1.83241121
142Microvesicular hepatic steatosis (HP:0001414)1.82311859
143Systemic lupus erythematosus (HP:0002725)1.82186288
144Hypophosphatemic rickets (HP:0004912)1.82038070
145Vascular calcification (HP:0004934)1.80611951
146Venous abnormality (HP:0002624)1.80019075
147Intrahepatic cholestasis (HP:0001406)1.79331960
148Slender build (HP:0001533)1.79144267
149Chondrocalcinosis (HP:0000934)1.76682121
150Malnutrition (HP:0004395)1.76511931
151Elbow flexion contracture (HP:0002987)1.76312863
152Breast hypoplasia (HP:0003187)1.76217261
153Redundant skin (HP:0001582)1.75734540
154Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74499116
155Abnormality of the peritoneum (HP:0002585)1.73349637
156Multiple enchondromatosis (HP:0005701)1.72044832
157Vertebral compression fractures (HP:0002953)1.71930809
158Knee flexion contracture (HP:0006380)1.71479185
159Abnormal cartilage morphology (HP:0002763)1.71298274
160Spontaneous hematomas (HP:0007420)1.70514600
161Abnormality of complement system (HP:0005339)1.69613101
162Nail dystrophy (HP:0008404)1.69425762
163Carpal bone hypoplasia (HP:0001498)1.67333694
164Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67205097
165Increased variability in muscle fiber diameter (HP:0003557)1.65678530
166Nausea (HP:0002018)1.65392672
167Persistence of primary teeth (HP:0006335)1.62967209
168Short middle phalanx of the 5th finger (HP:0004220)1.61466206
169Abnormality of sodium homeostasis (HP:0010931)1.57290576
170Abnormality of the tricuspid valve (HP:0001702)1.53956839
171Osteomalacia (HP:0002749)1.53494176
172Thrombophlebitis (HP:0004418)1.53399374
173Acne (HP:0001061)1.52762055
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.49969483
175Toxemia of pregnancy (HP:0100603)1.49525284
176Hypertriglyceridemia (HP:0002155)1.49105743
177Insomnia (HP:0100785)1.48986943
178Hyponatremia (HP:0002902)1.48900627
179Neoplasm of head and neck (HP:0012288)1.47495236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.29267982
2BUB13.09249668
3AKT32.94513945
4TRIB32.93187509
5NEK22.56824466
6CLK12.55025439
7JAK32.53518226
8LATS12.45570243
9FGFR42.41454667
10MAP3K32.35334948
11MST1R2.21436037
12CAMK1G2.10628391
13RIPK42.04384191
14STK32.03124652
15PRPF4B2.02765514
16LATS22.01593965
17TAOK21.99701292
18GRK61.97578550
19PKN21.93265302
20RIPK11.92253763
21ICK1.83895735
22ERN11.83397952
23MYLK1.82538161
24SIK11.81755098
25PTK2B1.75278555
26TEC1.74990314
27PLK41.69274978
28TRPM71.68522025
29STK101.68418765
30RPS6KC11.68246409
31RPS6KL11.68246409
32TTN1.67760412
33STK38L1.56971256
34BMPR21.54204494
35RPS6KA61.52317902
36PNCK1.48137934
37MAP2K31.46348885
38LRRK21.41719383
39BCKDK1.40643421
40TAOK31.39807737
41BTK1.37383382
42MAPK151.37049599
43MKNK21.34632949
44PTK61.28249036
45MAP3K101.28118671
46SRPK11.26993111
47CAMK1D1.25848146
48TYK21.25561423
49EEF2K1.23069966
50SYK1.21756582
51IRAK31.21042061
52TNK21.20433627
53RPS6KA41.20132943
54RPS6KA21.19318297
55MAP4K11.18228008
56DDR21.17052667
57CDK41.16410723
58MAP3K11.15697700
59TIE11.15451770
60PINK11.14260518
61PRKD21.12670489
62BRSK21.11842150
63TAOK11.10590975
64MAP3K61.09946587
65TBK11.09396497
66WEE11.07371109
67MAP2K21.01803275
68GRK71.01285036
69EPHA21.00917188
70MATK0.98967713
71PDGFRA0.97585455
72MAPKAPK30.96340747
73EPHB20.96098258
74GRK50.95799535
75HIPK20.94482223
76ADRBK20.94074375
77PAK20.93837345
78FES0.92530558
79ALK0.91124335
80PIM20.90792957
81STK40.90036434
82IKBKE0.87809653
83RET0.86867919
84RPS6KA50.84654183
85MST40.80639308
86IKBKB0.79638293
87WNK10.79166737
88FGFR10.77538392
89FER0.76663508
90CDC42BPA0.76145872
91KSR20.75532411
92KIT0.75024964
93MTOR0.74918395
94MAPK40.74779214
95BMX0.73468053
96MAP3K110.71576358
97KDR0.71077051
98AURKB0.70821803
99RAF10.70531479
100TGFBR20.70384905
101AURKA0.69931994
102MAP3K80.69890304
103EPHB10.69862316
104PRKAA20.69501071
105JAK10.69117021
106MAP3K50.66998521
107STK240.66411795
108MAPK30.65805384
109PIK3CG0.65608130
110ADRBK10.64866502
111JAK20.64810449
112MARK20.63350741
113TXK0.60740472
114MAP3K140.60636566
115DYRK1B0.60368858
116TTK0.60047097
117DYRK30.59983900
118MARK30.59132550
119FGFR30.57056753
120FLT30.55351099
121PRKCI0.54146648
122CCNB10.53480735
123MAPK110.53248916
124ZAP700.51703720
125PDK20.51656851
126EPHA30.51396693
127ACVR1B0.50403395
128FGFR20.49860571
129LYN0.49813315
130CDK60.49519795
131MKNK10.49015258
132EIF2AK10.49005778
133WNK30.48205765
134MAPK120.47639468
135NEK10.47552088
136PRKACG0.46686447
137MAP2K60.45702499
138MAPK10.43905564
139MET0.42733864
140SCYL20.42213572
141MAP3K20.40157271
142GSK3A0.39673826
143BRSK10.38148624
144STK380.37947517
145PIM10.36839378
146ABL20.36561363
147MAP3K70.35864662
148STK160.35837485
149RPS6KB20.34912888
150MAP2K10.34689896
151CDK70.34095227
152CHUK0.34090241
153PRKAA10.33319230
154PTK20.33103413

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.60597121
2Other glycan degradation_Homo sapiens_hsa005113.52835573
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.97614294
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69959189
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67868229
6Folate biosynthesis_Homo sapiens_hsa007902.60759245
7Vitamin digestion and absorption_Homo sapiens_hsa049772.59644463
8Nitrogen metabolism_Homo sapiens_hsa009102.53276174
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.38909021
10Asthma_Homo sapiens_hsa053102.37500974
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.33922282
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.33808285
13Hematopoietic cell lineage_Homo sapiens_hsa046401.98194751
14Platelet activation_Homo sapiens_hsa046111.96424321
15Complement and coagulation cascades_Homo sapiens_hsa046101.93830259
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92862774
17Acute myeloid leukemia_Homo sapiens_hsa052211.90428224
18African trypanosomiasis_Homo sapiens_hsa051431.81434079
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.73608648
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73240925
21Staphylococcus aureus infection_Homo sapiens_hsa051501.70729618
22Protein digestion and absorption_Homo sapiens_hsa049741.70374552
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.64404777
24Arginine biosynthesis_Homo sapiens_hsa002201.63329025
25ECM-receptor interaction_Homo sapiens_hsa045121.62115258
26Tryptophan metabolism_Homo sapiens_hsa003801.61996635
27Leishmaniasis_Homo sapiens_hsa051401.60887272
28Sulfur relay system_Homo sapiens_hsa041221.57093194
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.55586852
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54840423
31mTOR signaling pathway_Homo sapiens_hsa041501.50481573
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47640763
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.39795766
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36947965
35Fatty acid degradation_Homo sapiens_hsa000711.35618080
36Chronic myeloid leukemia_Homo sapiens_hsa052201.33532105
37PPAR signaling pathway_Homo sapiens_hsa033201.30591459
38Prolactin signaling pathway_Homo sapiens_hsa049171.30548581
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25492028
40p53 signaling pathway_Homo sapiens_hsa041151.23091386
41Butanoate metabolism_Homo sapiens_hsa006501.19249008
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18334374
43Non-small cell lung cancer_Homo sapiens_hsa052231.16780493
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.16191734
45Bile secretion_Homo sapiens_hsa049761.14552536
46Hedgehog signaling pathway_Homo sapiens_hsa043401.13401524
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12956763
48ABC transporters_Homo sapiens_hsa020101.10409989
49Osteoclast differentiation_Homo sapiens_hsa043801.08614693
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07880888
51Selenocompound metabolism_Homo sapiens_hsa004501.07183601
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07123991
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04288870
54Glycerolipid metabolism_Homo sapiens_hsa005611.03675110
55Caffeine metabolism_Homo sapiens_hsa002321.02628156
56Histidine metabolism_Homo sapiens_hsa003401.02185933
57Chemical carcinogenesis_Homo sapiens_hsa052041.01517397
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.00536373
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00007014
60beta-Alanine metabolism_Homo sapiens_hsa004100.99432107
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99279811
62Pentose phosphate pathway_Homo sapiens_hsa000300.99133506
63Influenza A_Homo sapiens_hsa051640.97146859
64Small cell lung cancer_Homo sapiens_hsa052220.93088416
65Biosynthesis of amino acids_Homo sapiens_hsa012300.92501151
66RNA polymerase_Homo sapiens_hsa030200.92201857
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91369069
68Systemic lupus erythematosus_Homo sapiens_hsa053220.88377939
69Hepatitis B_Homo sapiens_hsa051610.87087225
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86426867
71Regulation of autophagy_Homo sapiens_hsa041400.86125598
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86117235
73Toxoplasmosis_Homo sapiens_hsa051450.84384515
74Amoebiasis_Homo sapiens_hsa051460.84325105
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84313525
76Lysine degradation_Homo sapiens_hsa003100.83868909
77Rheumatoid arthritis_Homo sapiens_hsa053230.83451048
78Basal cell carcinoma_Homo sapiens_hsa052170.82283237
79B cell receptor signaling pathway_Homo sapiens_hsa046620.82217468
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82180016
81Peroxisome_Homo sapiens_hsa041460.80972217
82Measles_Homo sapiens_hsa051620.80030457
83Fatty acid metabolism_Homo sapiens_hsa012120.78986859
84Pertussis_Homo sapiens_hsa051330.78813836
85Retinol metabolism_Homo sapiens_hsa008300.77499909
86Pancreatic cancer_Homo sapiens_hsa052120.77129781
87VEGF signaling pathway_Homo sapiens_hsa043700.76718548
88Herpes simplex infection_Homo sapiens_hsa051680.76371038
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75585555
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.74583294
91Fat digestion and absorption_Homo sapiens_hsa049750.72256513
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69583451
93Hippo signaling pathway_Homo sapiens_hsa043900.68622994
94Malaria_Homo sapiens_hsa051440.68608108
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68097274
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67924756
97Bladder cancer_Homo sapiens_hsa052190.67053680
98Phenylalanine metabolism_Homo sapiens_hsa003600.66981774
99Insulin resistance_Homo sapiens_hsa049310.66749968
100Inositol phosphate metabolism_Homo sapiens_hsa005620.66359478
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66199192
102Tuberculosis_Homo sapiens_hsa051520.66081043
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.65656736
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65408001
105AMPK signaling pathway_Homo sapiens_hsa041520.64179772
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.63787567
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63548642
108Proteoglycans in cancer_Homo sapiens_hsa052050.62082861
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62011405
110Fructose and mannose metabolism_Homo sapiens_hsa000510.61676138
111FoxO signaling pathway_Homo sapiens_hsa040680.61016839
112Carbon metabolism_Homo sapiens_hsa012000.60491063
113Steroid biosynthesis_Homo sapiens_hsa001000.59079615
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58540565
115RNA transport_Homo sapiens_hsa030130.57121075
116Propanoate metabolism_Homo sapiens_hsa006400.55842912
117Type II diabetes mellitus_Homo sapiens_hsa049300.55782250
118Viral carcinogenesis_Homo sapiens_hsa052030.55074777
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54492354
120Glutathione metabolism_Homo sapiens_hsa004800.54420194
121Allograft rejection_Homo sapiens_hsa053300.54002645
122Choline metabolism in cancer_Homo sapiens_hsa052310.52696182
123Cell cycle_Homo sapiens_hsa041100.52646671
124Focal adhesion_Homo sapiens_hsa045100.52503526
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.52044080
126Ovarian steroidogenesis_Homo sapiens_hsa049130.52035520
127Dorso-ventral axis formation_Homo sapiens_hsa043200.51315156
128Melanoma_Homo sapiens_hsa052180.51070638
129Adherens junction_Homo sapiens_hsa045200.51065470
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51010854
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50906036
132Starch and sucrose metabolism_Homo sapiens_hsa005000.50583397
133Arginine and proline metabolism_Homo sapiens_hsa003300.50312157
134MicroRNAs in cancer_Homo sapiens_hsa052060.50076458
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47401139
136Arachidonic acid metabolism_Homo sapiens_hsa005900.47335018
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46922197
138Mineral absorption_Homo sapiens_hsa049780.45783642
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.45655795
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45110597
141Insulin signaling pathway_Homo sapiens_hsa049100.45072368
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44011389
143Linoleic acid metabolism_Homo sapiens_hsa005910.42500158
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41289066
145Lysosome_Homo sapiens_hsa041420.41218120
146One carbon pool by folate_Homo sapiens_hsa006700.38924688
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38859509
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.36844720
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36360296
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36084554
151Sphingolipid metabolism_Homo sapiens_hsa006000.35957120
152HTLV-I infection_Homo sapiens_hsa051660.35950497
153TNF signaling pathway_Homo sapiens_hsa046680.35732068
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34801669
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.33951286
156Apoptosis_Homo sapiens_hsa042100.31787757
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30135582
158Hepatitis C_Homo sapiens_hsa051600.27033784
159Fatty acid elongation_Homo sapiens_hsa000620.26834965
160TGF-beta signaling pathway_Homo sapiens_hsa043500.26800257
161Renal cell carcinoma_Homo sapiens_hsa052110.26485310

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