FAM69A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)5.00647466
2synaptic vesicle maturation (GO:0016188)4.88307566
3neutrophil activation involved in immune response (GO:0002283)4.33776307
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.23055579
5type B pancreatic cell proliferation (GO:0044342)4.06442449
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91172210
7peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.89807573
8phagosome maturation (GO:0090382)3.70667727
9L-serine transport (GO:0015825)3.69081345
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68513103
11protein heterotrimerization (GO:0070208)3.55260512
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51974882
13positive regulation of fibroblast migration (GO:0010763)3.47587649
14regulation of synaptic vesicle exocytosis (GO:2000300)3.44700421
15protein neddylation (GO:0045116)3.42949988
16cellular response to zinc ion (GO:0071294)3.41003335
17cellular potassium ion homeostasis (GO:0030007)3.40838615
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39555317
19ATP synthesis coupled proton transport (GO:0015986)3.39555317
20fatty acid elongation (GO:0030497)3.38546010
21neuronal action potential propagation (GO:0019227)3.31125594
22central nervous system myelination (GO:0022010)3.28468900
23axon ensheathment in central nervous system (GO:0032291)3.28468900
24response to gravity (GO:0009629)3.27460706
25sodium ion export (GO:0071436)3.27218033
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.22731533
27neuron cell-cell adhesion (GO:0007158)3.21417697
28gamma-aminobutyric acid transport (GO:0015812)3.20844086
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20687155
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.20687155
31NADH dehydrogenase complex assembly (GO:0010257)3.20687155
32regulation of cell communication by electrical coupling (GO:0010649)3.13060150
33respiratory electron transport chain (GO:0022904)3.12821538
34collagen fibril organization (GO:0030199)3.07353159
35mast cell activation (GO:0045576)3.04222169
36respiratory burst (GO:0045730)3.04128448
37cellular response to exogenous dsRNA (GO:0071360)3.02882699
38electron transport chain (GO:0022900)3.02671818
39chaperone-mediated protein transport (GO:0072321)3.01134677
40serine transport (GO:0032329)2.98865450
41long-chain fatty acid biosynthetic process (GO:0042759)2.98741097
42leukocyte aggregation (GO:0070486)2.98126844
43regulation of B cell receptor signaling pathway (GO:0050855)2.96503647
44negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94432863
45regulation of mitochondrial depolarization (GO:0051900)2.93327395
46amino acid import (GO:0043090)2.86396933
47positive regulation of monocyte chemotaxis (GO:0090026)2.85461230
48negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84101529
49regulation of clathrin-mediated endocytosis (GO:2000369)2.83188475
50negative regulation of neurotransmitter transport (GO:0051589)2.81747779
51protein complex biogenesis (GO:0070271)2.80352370
52positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78071024
53neutrophil activation (GO:0042119)2.77737806
54extracellular matrix assembly (GO:0085029)2.77520355
55transferrin transport (GO:0033572)2.76763281
56positive regulation of extracellular matrix organization (GO:1903055)2.75054412
57presynaptic membrane assembly (GO:0097105)2.73933975
58metanephric mesenchyme development (GO:0072075)2.73277141
59regulation of synaptic vesicle transport (GO:1902803)2.70130250
60superoxide anion generation (GO:0042554)2.68823982
61kidney mesenchyme development (GO:0072074)2.65017271
62dendritic cell migration (GO:0036336)2.64954047
63neurotransmitter secretion (GO:0007269)2.64706431
64acidic amino acid transport (GO:0015800)2.61464361
65regulation of T cell migration (GO:2000404)2.60691867
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60415361
67skin morphogenesis (GO:0043589)2.59394190
68neurotransmitter uptake (GO:0001504)2.58261254
69presynaptic membrane organization (GO:0097090)2.58143012
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58032872
71ferric iron transport (GO:0015682)2.57160735
72trivalent inorganic cation transport (GO:0072512)2.57160735
73substantia nigra development (GO:0021762)2.56761019
74L-amino acid import (GO:0043092)2.55915181
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55433497
76regulation of plasminogen activation (GO:0010755)2.54984893
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53768799
78ATP hydrolysis coupled proton transport (GO:0015991)2.53768799
79regulation of integrin-mediated signaling pathway (GO:2001044)2.52840104
80extracellular fibril organization (GO:0043206)2.52085231
81glutamate receptor signaling pathway (GO:0007215)2.51376358
82cell adhesion mediated by integrin (GO:0033627)2.46748314
83regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.46683563
84positive regulation of T cell migration (GO:2000406)2.46598406
85C4-dicarboxylate transport (GO:0015740)2.46468909
86synaptic transmission, glutamatergic (GO:0035249)2.46392956
87cullin deneddylation (GO:0010388)2.45770636
88granulocyte activation (GO:0036230)2.44943215
89neuronal ion channel clustering (GO:0045161)2.44759632
90myeloid cell activation involved in immune response (GO:0002275)2.44725143
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44300686
92activated T cell proliferation (GO:0050798)2.44218475
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44125875
94sphingomyelin metabolic process (GO:0006684)2.43748575
95apoptotic cell clearance (GO:0043277)2.43441954
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43365333
97protein localization to endosome (GO:0036010)2.43193349
98cell migration involved in heart development (GO:0060973)2.42460205
99dermatan sulfate biosynthetic process (GO:0030208)2.41992479
100membrane assembly (GO:0071709)2.40610559
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40574554
102Golgi to plasma membrane protein transport (GO:0043001)2.40544073
103relaxation of smooth muscle (GO:0044557)2.39832087
104negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39395934
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39105778
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.38526683
107mitochondrial respiratory chain complex assembly (GO:0033108)2.38368306
108positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.38363605
109potassium ion homeostasis (GO:0055075)2.37079425
110negative regulation of receptor-mediated endocytosis (GO:0048261)2.36527558
111startle response (GO:0001964)2.35175481
112cellular copper ion homeostasis (GO:0006878)2.33547826
113glycosphingolipid biosynthetic process (GO:0006688)2.32525573
114regulation of monocyte chemotaxis (GO:0090025)2.32356735
115regulation of neuronal synaptic plasticity (GO:0048168)2.31565074
116suckling behavior (GO:0001967)2.31178252
117positive regulation of pseudopodium assembly (GO:0031274)2.31118633
118chondrocyte proliferation (GO:0035988)2.30954899
119mannosylation (GO:0097502)2.30145361
120negative regulation of osteoblast proliferation (GO:0033689)2.30044943
121dendritic cell chemotaxis (GO:0002407)2.30010473
122regulation of dendritic spine development (GO:0060998)2.29264757
123membrane raft organization (GO:0031579)2.29149001
124chondroitin sulfate catabolic process (GO:0030207)2.28208377
125protein carboxylation (GO:0018214)2.28128433
126peptidyl-glutamic acid carboxylation (GO:0017187)2.28128433
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28056303
128defense response to protozoan (GO:0042832)2.28045007
129regulation of platelet aggregation (GO:0090330)2.27637674
130regulation of dendritic spine morphogenesis (GO:0061001)2.27326679
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.27097518
132L-glutamate transport (GO:0015813)2.26293263
133positive regulation of muscle hypertrophy (GO:0014742)2.26263788
134positive regulation of cardiac muscle hypertrophy (GO:0010613)2.26263788
135regulation of synapse structural plasticity (GO:0051823)2.25388473
136regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.25297177
137protein retention in ER lumen (GO:0006621)2.25198157
138Rap protein signal transduction (GO:0032486)2.24666276
139regulation of collateral sprouting (GO:0048670)2.23801999
140pericardium development (GO:0060039)2.23365759
141lipid particle organization (GO:0034389)2.23057901
142regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.22676607
143fibril organization (GO:0097435)2.22605071
144T-helper 1 type immune response (GO:0042088)2.22544609
145necrotic cell death (GO:0070265)2.22439724
146developmental pigmentation (GO:0048066)2.22346419
147leukocyte mediated cytotoxicity (GO:0001909)2.22340211
148regulation of lymphocyte migration (GO:2000401)2.22078993
149activation of protein kinase B activity (GO:0032148)2.21992153
150cytochrome complex assembly (GO:0017004)2.21824397
151negative regulation of protein localization to plasma membrane (GO:1903077)2.21661463
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.21531780
153myeloid dendritic cell activation (GO:0001773)2.20888361
154transmission of nerve impulse (GO:0019226)2.20211906
155regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.19951633
156negative regulation of interleukin-17 production (GO:0032700)2.19889481
157T cell migration (GO:0072678)2.19759183
158proton transport (GO:0015992)2.18356761
159positive regulation of axon extension (GO:0045773)2.17914969
160response to protozoan (GO:0001562)2.17729067
161cellular response to interferon-beta (GO:0035458)2.17464329
162positive regulation of actin filament depolymerization (GO:0030836)2.17299154
163regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.17266843
164sequestering of extracellular ligand from receptor (GO:0035581)2.17154337
165gonadal mesoderm development (GO:0007506)2.16525899
166potassium ion import (GO:0010107)2.16458273
167mast cell activation involved in immune response (GO:0002279)2.16124691
168mast cell degranulation (GO:0043303)2.16124691
169regulation of neurotransmitter secretion (GO:0046928)2.15632278
170respiratory chain complex IV assembly (GO:0008535)2.15447606
171hydrogen transport (GO:0006818)2.15279521
172regulation of interferon-beta biosynthetic process (GO:0045357)2.15238116
173leukocyte degranulation (GO:0043299)2.15112497
174regulation of neuron projection regeneration (GO:0070570)2.14888170
175regulation of axon regeneration (GO:0048679)2.14888170
176regulation of mitochondrial fission (GO:0090140)2.14217059
177immunoglobulin mediated immune response (GO:0016064)2.13689432
178lymphocyte chemotaxis (GO:0048247)2.12722813
179microglial cell activation (GO:0001774)2.12278666
180positive regulation of mitochondrial fission (GO:0090141)2.11728356
181positive regulation of synapse assembly (GO:0051965)2.11447973
182neuron-neuron synaptic transmission (GO:0007270)2.11080264
183positive regulation of lymphocyte migration (GO:2000403)2.10788333
184regulation of pigment cell differentiation (GO:0050932)2.10291592
185hydrogen ion transmembrane transport (GO:1902600)2.10067812
186negative regulation of neurotransmitter secretion (GO:0046929)2.09909115
187interferon-gamma-mediated signaling pathway (GO:0060333)2.08573008
188synaptic vesicle exocytosis (GO:0016079)2.08567734
189establishment of protein localization to mitochondrial membrane (GO:0090151)2.08021726
190positive regulation of alpha-beta T cell proliferation (GO:0046641)2.08006955
191B cell receptor signaling pathway (GO:0050853)2.07506293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.21999727
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.62888532
3EZH2_22144423_ChIP-Seq_EOC_Human3.53861212
4GBX2_23144817_ChIP-Seq_PC3_Human3.52183764
5TAF15_26573619_Chip-Seq_HEK293_Human3.38276996
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36807414
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.30857528
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.26458012
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23382743
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.00661541
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95407787
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61267897
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51967306
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48748634
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28785051
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22260031
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09655221
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05812279
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02452851
20TP53_18474530_ChIP-ChIP_U2OS_Human2.02383682
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95939457
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89524843
23AR_21572438_ChIP-Seq_LNCaP_Human1.86641113
24P300_19829295_ChIP-Seq_ESCs_Human1.85807985
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85253551
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.84952530
27ER_23166858_ChIP-Seq_MCF-7_Human1.83361303
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.82218017
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80731408
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.78014650
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74530100
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72131137
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68356471
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.67306976
35FUS_26573619_Chip-Seq_HEK293_Human1.63837835
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62233594
37BRD4_25478319_ChIP-Seq_HGPS_Human1.62134193
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62038262
39* CJUN_26792858_Chip-Seq_BT549_Human1.60563424
40EWS_26573619_Chip-Seq_HEK293_Human1.55750358
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54707522
42* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53198957
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52258936
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.51231618
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48184025
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46633066
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45502182
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43580484
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42567505
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41613652
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40410450
52VDR_22108803_ChIP-Seq_LS180_Human1.38627466
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38134808
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37876502
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37425277
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37083156
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35867028
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33412485
59P53_22387025_ChIP-Seq_ESCs_Mouse1.32228151
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.32027418
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30880241
62* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30075418
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.29189659
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28778621
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28239529
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28040574
67SMAD4_21799915_ChIP-Seq_A2780_Human1.27944129
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27092630
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27037988
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.26515742
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.26355670
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.25488236
73TP53_16413492_ChIP-PET_HCT116_Human1.25290697
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.24937089
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24578506
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24171097
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23598179
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23191234
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22961101
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.22240659
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22178174
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.22014222
83JUN_21703547_ChIP-Seq_K562_Human1.21980117
84* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21410566
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20791870
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20593661
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20166946
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.19894956
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.19778800
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19275020
91P300_18555785_Chip-Seq_ESCs_Mouse1.19267665
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19226582
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19040735
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.17018066
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16897601
96* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16897601
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.16594665
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15369659
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14669315
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14154322
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14100480
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.14082895
103ELK1_19687146_ChIP-ChIP_HELA_Human1.12480585
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12241335
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12241335
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.12155031
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.10583655
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.09825291
109RUNX_20019798_ChIP-Seq_JUKART_Human1.09790760
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09582724
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09301700
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.09291231
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09053678
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08712734
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08533582
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08512927
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08370739
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07871796
119AR_25329375_ChIP-Seq_VCAP_Human1.07480428
120RNF2_27304074_Chip-Seq_NSC_Mouse1.06291699
121SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06231109
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06168057
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05849427
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05844587
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05822437
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.05145895
127* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04891433
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04281271
129CLOCK_20551151_ChIP-Seq_293T_Human1.03794272
130MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03332308
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02173597
132STAT3_23295773_ChIP-Seq_U87_Human1.02063705
133CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01914716
134PU1_27457419_Chip-Seq_LIVER_Mouse1.01866976
135SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01371546
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01340760
137* SOX2_20726797_ChIP-Seq_SW620_Human0.99856862
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99378794
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98029085
140BCAT_22108803_ChIP-Seq_LS180_Human0.96420287
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.95591788
142KDM2B_26808549_Chip-Seq_REH_Human0.94756930
143MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94730706
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.92842611
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90401488
146* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89169312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.28732977
2MP0003880_abnormal_central_pattern4.59835500
3MP0003724_increased_susceptibility_to3.25913759
4MP0001835_abnormal_antigen_presentation3.21284692
5MP0001958_emphysema3.09366508
6MP0005503_abnormal_tendon_morphology3.04511760
7MP0006054_spinal_hemorrhage3.04011373
8MP0005275_abnormal_skin_tensile2.94834617
9MP0001529_abnormal_vocalization2.89429535
10MP0005623_abnormal_meninges_morphology2.69792887
11MP0002148_abnormal_hypersensitivity_rea2.63534730
12MP0003279_aneurysm2.53391622
13MP0000920_abnormal_myelination2.44019343
14MP0009785_altered_susceptibility_to2.43586771
15MP0001905_abnormal_dopamine_level2.31668513
16MP0005671_abnormal_response_to2.28855236
17MP0001542_abnormal_bone_strength2.24171507
18MP0003950_abnormal_plasma_membrane2.21252151
19MP0004859_abnormal_synaptic_plasticity2.21174281
20MP0009745_abnormal_behavioral_response2.19261698
21MP0002736_abnormal_nociception_after2.18570006
22MP0005000_abnormal_immune_tolerance2.18343362
23MP0009046_muscle_twitch2.14416806
24MP0009379_abnormal_foot_pigmentation2.13296925
25MP0005423_abnormal_somatic_nervous2.13149448
26MP0002064_seizures2.09227027
27MP0003635_abnormal_synaptic_transmissio2.05573339
28MP0002272_abnormal_nervous_system2.04396296
29MP0003705_abnormal_hypodermis_morpholog2.01631016
30MP0001968_abnormal_touch/_nociception1.96686907
31MP0004272_abnormal_basement_membrane1.95515463
32MP0004142_abnormal_muscle_tone1.94037208
33MP0000751_myopathy1.93958928
34MP0002419_abnormal_innate_immunity1.93152553
35MP0005387_immune_system_phenotype1.87502196
36MP0001790_abnormal_immune_system1.87502196
37MP0001486_abnormal_startle_reflex1.82938616
38MP0005257_abnormal_intraocular_pressure1.80867330
39MP0010386_abnormal_urinary_bladder1.80368287
40MP0002295_abnormal_pulmonary_circulatio1.79101323
41MP0001800_abnormal_humoral_immune1.75703477
42MP0000372_irregular_coat_pigmentation1.74689621
43MP0005025_abnormal_response_to1.71222801
44MP0002452_abnormal_antigen_presenting1.69441377
45MP0009780_abnormal_chondrocyte_physiolo1.68828112
46MP0002063_abnormal_learning/memory/cond1.66805787
47MP0003091_abnormal_cell_migration1.65640571
48MP0002723_abnormal_immune_serum1.65561867
49MP0004270_analgesia1.63503327
50MP0002420_abnormal_adaptive_immunity1.58567389
51MP0001299_abnormal_eye_distance/1.58455993
52MP0001819_abnormal_immune_cell1.58404569
53MP0003690_abnormal_glial_cell1.57370548
54MP0002572_abnormal_emotion/affect_behav1.56424419
55MP0002734_abnormal_mechanical_nocicepti1.54815556
56MP0003436_decreased_susceptibility_to1.40945877
57MP0002735_abnormal_chemical_nociception1.40498382
58MP0006276_abnormal_autonomic_nervous1.40097579
59MP0001501_abnormal_sleep_pattern1.39748302
60MP0000778_abnormal_nervous_system1.38449773
61MP0005023_abnormal_wound_healing1.38336097
62MP0002067_abnormal_sensory_capabilities1.37043155
63MP0003633_abnormal_nervous_system1.35016985
64MP0006082_CNS_inflammation1.34302868
65MP0001188_hyperpigmentation1.34116676
66MP0003136_yellow_coat_color1.31516277
67MP0004742_abnormal_vestibular_system1.26465046
68MP0000569_abnormal_digit_pigmentation1.26217731
69MP0004883_abnormal_blood_vessel1.26134340
70MP0005171_absent_coat_pigmentation1.23434759
71MP0001243_abnormal_dermal_layer1.22277738
72MP0003329_amyloid_beta_deposits1.19840984
73MP0000749_muscle_degeneration1.18757851
74MP0003566_abnormal_cell_adhesion1.16994790
75MP0000015_abnormal_ear_pigmentation1.16409019
76MP0005164_abnormal_response_to1.16101800
77MP0001440_abnormal_grooming_behavior1.15598862
78MP0009840_abnormal_foam_cell1.15483924
79MP0000685_abnormal_immune_system1.14157572
80MP0003868_abnormal_feces_composition1.14016622
81MP0000013_abnormal_adipose_tissue1.12414496
82MP0005174_abnormal_tail_pigmentation1.12036422
83MP0001970_abnormal_pain_threshold1.11929963
84MP0009764_decreased_sensitivity_to1.11726941
85MP0005187_abnormal_penis_morphology1.11099176
86MP0005075_abnormal_melanosome_morpholog1.09999241
87MP0003448_altered_tumor_morphology1.06318722
88MP0000716_abnormal_immune_system1.06004128
89MP0009384_cardiac_valve_regurgitation1.04847941
90MP0005310_abnormal_salivary_gland1.04598083
91MP0003252_abnormal_bile_duct1.04428723
92MP0004147_increased_porphyrin_level1.04075578
93MP0002060_abnormal_skin_morphology1.03141185
94MP0004924_abnormal_behavior1.02104930
95MP0005386_behavior/neurological_phenoty1.02104930
96MP0003634_abnormal_glial_cell1.01651304
97MP0003075_altered_response_to0.99769136
98MP0008569_lethality_at_weaning0.99730845
99MP0005645_abnormal_hypothalamus_physiol0.99523815
100MP0000767_abnormal_smooth_muscle0.98451027
101MP0000465_gastrointestinal_hemorrhage0.97228065
102MP0002398_abnormal_bone_marrow0.96985860
103MP0008789_abnormal_olfactory_epithelium0.96144408
104MP0000604_amyloidosis0.93914826
105MP0003303_peritoneal_inflammation0.93756706
106MP0005595_abnormal_vascular_smooth0.93614231
107MP0002139_abnormal_hepatobiliary_system0.93587838
108MP0001986_abnormal_taste_sensitivity0.92952386
109MP0005085_abnormal_gallbladder_physiolo0.92559823
110MP0002090_abnormal_vision0.92454813
111MP0004510_myositis0.91827256
112MP0000343_altered_response_to0.91720798
113MP0003283_abnormal_digestive_organ0.91522911
114MP0004381_abnormal_hair_follicle0.91110921
115MP0002277_abnormal_respiratory_mucosa0.91057490
116MP0002971_abnormal_brown_adipose0.90291839
117MP0005409_darkened_coat_color0.90029376
118MP0000538_abnormal_urinary_bladder0.89925335
119MP0005508_abnormal_skeleton_morphology0.89549014
120MP0001984_abnormal_olfaction0.89504722
121MP0002095_abnormal_skin_pigmentation0.89346470
122MP0005365_abnormal_bile_salt0.89273891
123MP0001177_atelectasis0.88471196
124MP0001533_abnormal_skeleton_physiology0.86299800
125MP0002876_abnormal_thyroid_physiology0.85340660
126MP0008260_abnormal_autophagy0.84865595
127MP0002066_abnormal_motor_capabilities/c0.83774497
128MP0002557_abnormal_social/conspecific_i0.83614544
129MP0005166_decreased_susceptibility_to0.82976802
130MP0001346_abnormal_lacrimal_gland0.82743736
131MP0009333_abnormal_splenocyte_physiolog0.82612759
132MP0001963_abnormal_hearing_physiology0.82002407
133MP0002638_abnormal_pupillary_reflex0.81392008
134MP0005058_abnormal_lysosome_morphology0.80107299
135MP0003631_nervous_system_phenotype0.79513920
136MP0002877_abnormal_melanocyte_morpholog0.79269006
137MP0005388_respiratory_system_phenotype0.78835786
138MP0002133_abnormal_respiratory_system0.78835786
139MP0010368_abnormal_lymphatic_system0.78790586
140MP0000681_abnormal_thyroid_gland0.78382344
141MP0003191_abnormal_cellular_cholesterol0.78170593
142MP0006292_abnormal_olfactory_placode0.77494631
143MP0004811_abnormal_neuron_physiology0.77144213
144MP0002184_abnormal_innervation0.76912594
145MP0003763_abnormal_thymus_physiology0.76188009
146MP0003632_abnormal_nervous_system0.75709393
147MP0003186_abnormal_redox_activity0.75686940
148MP0005499_abnormal_olfactory_system0.75535083
149MP0005394_taste/olfaction_phenotype0.75535083
150MP0008874_decreased_physiological_sensi0.75075631
151MP0001502_abnormal_circadian_rhythm0.73195897
152MP0002896_abnormal_bone_mineralization0.72583287
153MP0005551_abnormal_eye_electrophysiolog0.71595281
154MP0000003_abnormal_adipose_tissue0.69688455
155MP0004134_abnormal_chest_morphology0.65903150
156MP0002168_other_aberrant_phenotype0.65496653
157MP0000747_muscle_weakness0.65264156
158MP0004215_abnormal_myocardial_fiber0.65149666
159MP0000762_abnormal_tongue_morphology0.63891547
160MP0000759_abnormal_skeletal_muscle0.63738076
161MP0001348_abnormal_lacrimal_gland0.63564727

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)5.48554923
2Protrusio acetabuli (HP:0003179)5.39710604
3Arterial tortuosity (HP:0005116)5.01969452
4Aortic dissection (HP:0002647)4.99993119
5Premature rupture of membranes (HP:0001788)4.96955430
6Aortic aneurysm (HP:0004942)4.61410922
7Parakeratosis (HP:0001036)4.56390926
8Action tremor (HP:0002345)4.12570112
9Atrophic scars (HP:0001075)4.03291095
10Acute necrotizing encephalopathy (HP:0006965)4.02497907
11Recurrent abscess formation (HP:0002722)3.99081479
12Stomatitis (HP:0010280)3.79307282
13Focal motor seizures (HP:0011153)3.65449892
14Mitochondrial inheritance (HP:0001427)3.62623109
15Abnormal mitochondria in muscle tissue (HP:0008316)3.49599553
16Abnormality of glycolysis (HP:0004366)3.48997236
17Increased serum pyruvate (HP:0003542)3.48997236
18Progressive macrocephaly (HP:0004481)3.44293167
19Recurrent bacterial skin infections (HP:0005406)3.43277109
20Hepatocellular necrosis (HP:0001404)3.32881303
21Follicular hyperkeratosis (HP:0007502)3.23080685
22Acute encephalopathy (HP:0006846)3.04015198
23Soft skin (HP:0000977)3.02534201
24Tetraparesis (HP:0002273)2.93859385
25Increased CSF lactate (HP:0002490)2.93399065
26Obstructive lung disease (HP:0006536)2.92049619
27Chronic obstructive pulmonary disease (HP:0006510)2.92049619
28Elevated erythrocyte sedimentation rate (HP:0003565)2.85982055
29Scanning speech (HP:0002168)2.84917297
30Abnormal hair whorl (HP:0010721)2.77537726
31Hypothermia (HP:0002045)2.76263621
32Recurrent skin infections (HP:0001581)2.76198643
33Polyphagia (HP:0002591)2.73715261
34Spondylolisthesis (HP:0003302)2.71595124
35Abnormality of macrophages (HP:0004311)2.71245196
36Agammaglobulinemia (HP:0004432)2.69641889
37Atonic seizures (HP:0010819)2.69300467
38Dilatation of the ascending aorta (HP:0005111)2.69155790
39Wormian bones (HP:0002645)2.68383068
40Renal Fanconi syndrome (HP:0001994)2.62125998
41Torticollis (HP:0000473)2.61760769
42Delayed gross motor development (HP:0002194)2.59029409
43Febrile seizures (HP:0002373)2.59008353
44Ankle contracture (HP:0006466)2.58514252
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58353990
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54459724
47Mild short stature (HP:0003502)2.52923574
48Increased IgM level (HP:0003496)2.51691253
49Recurrent cutaneous fungal infections (HP:0011370)2.50303603
50Chronic mucocutaneous candidiasis (HP:0002728)2.50303603
51Eczematoid dermatitis (HP:0000976)2.50132718
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49327557
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.49327557
54Reduced subcutaneous adipose tissue (HP:0003758)2.48564402
553-Methylglutaconic aciduria (HP:0003535)2.48166574
56Patchy hypopigmentation of hair (HP:0011365)2.47565392
57Akinesia (HP:0002304)2.47551657
58Vertebral compression fractures (HP:0002953)2.47132825
59Hepatic necrosis (HP:0002605)2.44797809
60Increased hepatocellular lipid droplets (HP:0006565)2.42635473
61Truncal ataxia (HP:0002078)2.40483984
62Vacuolated lymphocytes (HP:0001922)2.37405896
63Myokymia (HP:0002411)2.37012162
64Glucose intolerance (HP:0000833)2.36989446
65Bladder diverticulum (HP:0000015)2.36190455
66Mediastinal lymphadenopathy (HP:0100721)2.34677003
67Leukodystrophy (HP:0002415)2.33499065
68Recurrent viral infections (HP:0004429)2.32402481
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31399563
70Mutism (HP:0002300)2.24591263
71Respiratory failure (HP:0002878)2.24127104
72Horizontal nystagmus (HP:0000666)2.22925264
73Retinal dysplasia (HP:0007973)2.22656111
74Medial flaring of the eyebrow (HP:0010747)2.21556728
75Aortic regurgitation (HP:0001659)2.20352504
76Optic disc pallor (HP:0000543)2.18882728
77Hypoplasia of the iris (HP:0007676)2.18537474
78Gait imbalance (HP:0002141)2.18536908
79Postural tremor (HP:0002174)2.18505120
80Neurofibrillary tangles (HP:0002185)2.17959973
81Neonatal short-limb short stature (HP:0008921)2.17334912
82Peritonitis (HP:0002586)2.17333658
83Cerebral inclusion bodies (HP:0100314)2.15781848
84Hand muscle atrophy (HP:0009130)2.15370347
85Panhypogammaglobulinemia (HP:0003139)2.14245201
86Slender build (HP:0001533)2.13127845
87Recurrent fungal infections (HP:0002841)2.12651099
88Recurrent sinusitis (HP:0011108)2.10862994
89Type 1 muscle fiber predominance (HP:0003803)2.10497910
90Cerebral aneurysm (HP:0004944)2.09728214
91Lower limb muscle weakness (HP:0007340)2.08867904
92Fragile skin (HP:0001030)2.08356611
93Recurrent gram-negative bacterial infections (HP:0005420)2.08135585
94Craniofacial dystonia (HP:0012179)2.07246707
95Exercise intolerance (HP:0003546)2.07153572
96Amniotic constriction ring (HP:0009775)2.06028774
97Abnormality of placental membranes (HP:0011409)2.06028774
98Absence seizures (HP:0002121)2.04321679
99Meningitis (HP:0001287)2.04196549
100Hepatosplenomegaly (HP:0001433)2.03068001
101Exertional dyspnea (HP:0002875)2.02696054
102Focal seizures (HP:0007359)2.02513520
103Coronal craniosynostosis (HP:0004440)2.00756448
104Intention tremor (HP:0002080)2.00065054
105Dysmetria (HP:0001310)1.98943751
106IgM deficiency (HP:0002850)1.98032317
107Focal dystonia (HP:0004373)1.97026200
108Mitral valve prolapse (HP:0001634)1.96400342
109Progressive inability to walk (HP:0002505)1.96129293
110IgG deficiency (HP:0004315)1.95637203
111Limb dystonia (HP:0002451)1.93761172
112Autoamputation (HP:0001218)1.92889576
113Gastrointestinal stroma tumor (HP:0100723)1.92632794
114Ankle clonus (HP:0011448)1.92585196
115Generalized tonic-clonic seizures (HP:0002069)1.92408665
116Mitral stenosis (HP:0001718)1.91691185
117Supranuclear gaze palsy (HP:0000605)1.91599831
118Purpura (HP:0000979)1.90798448
119Papilledema (HP:0001085)1.90362353
120Broad-based gait (HP:0002136)1.90328227
121White forelock (HP:0002211)1.89082880
122Congenital primary aphakia (HP:0007707)1.88630432
123Limb-girdle muscle weakness (HP:0003325)1.88181200
124Bowel diverticulosis (HP:0005222)1.88025337
125Cardiovascular calcification (HP:0011915)1.87773879
126Heterochromia iridis (HP:0001100)1.86991239
127Distal upper limb amyotrophy (HP:0007149)1.86834837
128Upper limb amyotrophy (HP:0009129)1.86834837
129Stridor (HP:0010307)1.86797535
130Chronic sinusitis (HP:0011109)1.86496868
131Osteolytic defects of the hand bones (HP:0009699)1.86252400
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.86252400
133Syringomyelia (HP:0003396)1.86032499
134Spinal cord lesions (HP:0100561)1.86032499
135Lipid accumulation in hepatocytes (HP:0006561)1.85956479
136Cerebral hemorrhage (HP:0001342)1.85680084
137Visual hallucinations (HP:0002367)1.85603102
138Type 2 muscle fiber atrophy (HP:0003554)1.84371912
139Nephrogenic diabetes insipidus (HP:0009806)1.83553041
140Esotropia (HP:0000565)1.82988660
141Eosinophilia (HP:0001880)1.82929761
142Abnormal ciliary motility (HP:0012262)1.82228331
143Abnormality of the corticospinal tract (HP:0002492)1.81953126
144Diplopia (HP:0000651)1.81868158
145Abnormality of binocular vision (HP:0011514)1.81868158
146Dialeptic seizures (HP:0011146)1.81580781
147Fetal akinesia sequence (HP:0001989)1.81468080
148Vasculitis (HP:0002633)1.81255594
149Axonal loss (HP:0003447)1.80932140
150Pheochromocytoma (HP:0002666)1.80717004
151Abnormality of dentin (HP:0010299)1.80475883
152Peripheral hypomyelination (HP:0007182)1.80166905
153Biconcave vertebral bodies (HP:0004586)1.79688601
154Upper limb muscle weakness (HP:0003484)1.79445527
155X-linked dominant inheritance (HP:0001423)1.78566017
156Hypergammaglobulinemia (HP:0010702)1.78530365
157Epileptic encephalopathy (HP:0200134)1.78453556
158Abnormality of eosinophils (HP:0001879)1.78291521
159Hyperventilation (HP:0002883)1.77920462
160Abnormal eating behavior (HP:0100738)1.77656054
161Cervical subluxation (HP:0003308)1.77619132
162Spastic gait (HP:0002064)1.77381090
163Hemiplegia (HP:0002301)1.76667149
164Insidious onset (HP:0003587)1.76521481
165Termporal pattern (HP:0011008)1.76521481
166Abnormal delivery (HP:0001787)1.75673590
167Increased intramyocellular lipid droplets (HP:0012240)1.75221806
168Hammertoe (HP:0001765)1.74158575
169Urinary urgency (HP:0000012)1.74154456
170Conjugated hyperbilirubinemia (HP:0002908)1.71838792
171Chronic otitis media (HP:0000389)1.71440248
172Ectopia lentis (HP:0001083)1.71324865
173Myositis (HP:0100614)1.70753553
174Overgrowth (HP:0001548)1.69263682
175Dysdiadochokinesis (HP:0002075)1.66864033
176Flared iliac wings (HP:0002869)1.64299658
177Tetraplegia (HP:0002445)1.62687766
178Upper motor neuron abnormality (HP:0002127)1.62044822
179Ulnar bowing (HP:0003031)1.62029341
180Hydroxyprolinuria (HP:0003080)1.61960339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.27505412
2BLK3.02396714
3IRAK42.67264947
4RIPK42.49997625
5CASK2.41116584
6MAP3K142.32782797
7PAK62.31408145
8DDR22.22106010
9MAP3K132.18130454
10TGFBR22.15636275
11TNIK2.13058518
12MST42.09008559
13TESK12.06795773
14PBK2.06144782
15BMPR22.01699500
16STK392.01613756
17FES1.96525673
18PDGFRA1.92857049
19NTRK11.89501250
20PRKD31.86052974
21BCR1.82824937
22MAP2K61.69791952
23ARAF1.68753304
24OXSR11.64285361
25LATS21.64099725
26TXK1.57305082
27MAPK131.55481707
28MARK11.51993612
29BMPR1B1.51548877
30STK381.50958324
31MAP4K11.49223231
32SIK31.44675430
33CDK191.38977810
34TRIM281.38593068
35KIT1.38024184
36PRPF4B1.33042134
37PLK21.29881750
38PAK31.28072087
39GRK71.27389304
40PRKCH1.26499501
41NEK61.24613223
42CAMKK21.23190931
43PAK21.21776114
44PKN11.21419351
45MAP2K71.18695619
46TEC1.13765855
47SYK1.10372567
48MINK11.09331352
49NTRK31.08707080
50PIM21.08332830
51EIF2AK31.05453259
52MYLK1.05415352
53EPHA31.03919863
54EIF2AK11.03834680
55RIPK11.00871238
56TYK21.00636508
57CAMK2G0.99712673
58CDK180.99326248
59EIF2AK20.99265106
60IKBKE0.98973280
61LIMK10.98488161
62ADRBK10.98444770
63CLK10.97075916
64PRKCQ0.97045204
65IRAK10.95782716
66MAPKAPK50.95547374
67PIK3CG0.94777709
68STK160.92479405
69CDK140.91333689
70CDK150.90482087
71MOS0.90361257
72CSNK1G30.89388683
73CSNK1A1L0.88165404
74IRAK20.87202668
75SCYL20.86787330
76TBK10.83239546
77PRKCG0.82136735
78IKBKB0.81762843
79PDGFRB0.80697157
80LATS10.80036019
81NME10.78319086
82CSNK1G20.77959782
83ABL20.77818725
84EPHA40.77779412
85CDK11A0.76387139
86ADRBK20.75695813
87PRKD20.75442196
88UHMK10.75367914
89RAF10.75264994
90ERBB30.74915572
91LYN0.74272049
92DYRK20.73750546
93ROCK10.72636107
94FGR0.72322430
95CSF1R0.72312670
96CAMK2B0.72109262
97PRKCE0.70387198
98CAMK2D0.70128189
99ERBB40.69291834
100TLK10.66514024
101MAP3K90.63962475
102NTRK20.63411153
103AKT30.63038908
104PRKD10.62676098
105LCK0.62512769
106VRK10.61247924
107MKNK20.61116404
108MKNK10.58903300
109CDK80.58557541
110CAMK2A0.58026268
111CSNK1G10.57923601
112ZAK0.57917951
113TRPM70.57425909
114DAPK10.57248828
115ACVR1B0.56725581
116PTK20.56038935
117MAPK70.53642009
118GRK50.53456806
119FER0.53202395
120BRSK10.52819723
121ROCK20.52579954
122JAK10.52004502
123STK38L0.51147063
124PRKG10.48913070
125PDK10.47435026
126ERN10.46068752
127IRAK30.45993109
128NLK0.45403533
129INSR0.45366320
130CDK50.45266080
131NME20.44201310
132MUSK0.43758866
133DYRK1A0.43678607
134BUB10.43055690
135FYN0.42026494
136MET0.40861447
137STK240.40386051
138CAMK10.39966644
139MAPK120.39617272
140PDK20.38716363
141EPHB10.38035740
142PAK40.37794004
143HCK0.37141348
144SIK20.37087114
145PRKCD0.36931216
146CAMKK10.36731172
147NEK90.36627066
148PRKCA0.36039840
149TNK20.35758844
150CSNK1D0.35700358
151YES10.34779778
152PTK2B0.34638803
153SGK4940.33982577
154SGK2230.33982577
155TYRO30.32856491

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.62770476
2Parkinsons disease_Homo sapiens_hsa050122.80795943
3Collecting duct acid secretion_Homo sapiens_hsa049662.65006930
4Proteasome_Homo sapiens_hsa030502.55888718
5Alzheimers disease_Homo sapiens_hsa050102.39689660
6Rheumatoid arthritis_Homo sapiens_hsa053232.35366652
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34170392
8Nicotine addiction_Homo sapiens_hsa050332.21604553
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21165662
10Graft-versus-host disease_Homo sapiens_hsa053322.16440955
11Fatty acid biosynthesis_Homo sapiens_hsa000612.14039173
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.02302898
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01711948
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93857483
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81240665
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79040599
17Huntingtons disease_Homo sapiens_hsa050161.78612928
18Phagosome_Homo sapiens_hsa041451.74265877
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.73483402
20Primary immunodeficiency_Homo sapiens_hsa053401.68117784
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66720980
22Synaptic vesicle cycle_Homo sapiens_hsa047211.65620283
23Allograft rejection_Homo sapiens_hsa053301.65009167
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.64230101
25Vitamin B6 metabolism_Homo sapiens_hsa007501.58148104
26Steroid biosynthesis_Homo sapiens_hsa001001.57956350
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49282343
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.48668405
29Vibrio cholerae infection_Homo sapiens_hsa051101.44918338
30Fatty acid elongation_Homo sapiens_hsa000621.41698942
31Protein export_Homo sapiens_hsa030601.38053914
32Serotonergic synapse_Homo sapiens_hsa047261.36453254
33GABAergic synapse_Homo sapiens_hsa047271.36049728
34Ribosome_Homo sapiens_hsa030101.34256252
35Complement and coagulation cascades_Homo sapiens_hsa046101.34056231
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33539444
37Leishmaniasis_Homo sapiens_hsa051401.32444350
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31749277
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30078767
40Propanoate metabolism_Homo sapiens_hsa006401.28404541
41Pertussis_Homo sapiens_hsa051331.27819881
42Morphine addiction_Homo sapiens_hsa050321.27788124
43Autoimmune thyroid disease_Homo sapiens_hsa053201.26568218
44Fatty acid metabolism_Homo sapiens_hsa012121.25135808
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25110953
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24772029
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23390368
48ECM-receptor interaction_Homo sapiens_hsa045121.23206448
49Long-term depression_Homo sapiens_hsa047301.22605660
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21579240
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18230270
52Glutamatergic synapse_Homo sapiens_hsa047241.17934939
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15882249
54RNA polymerase_Homo sapiens_hsa030201.13938727
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13714575
56Circadian rhythm_Homo sapiens_hsa047101.08653808
57Pyruvate metabolism_Homo sapiens_hsa006201.08167277
58Malaria_Homo sapiens_hsa051441.07992543
59Cocaine addiction_Homo sapiens_hsa050301.05989013
60Type I diabetes mellitus_Homo sapiens_hsa049401.05868049
61Tuberculosis_Homo sapiens_hsa051521.05046018
62PPAR signaling pathway_Homo sapiens_hsa033201.04856264
63Focal adhesion_Homo sapiens_hsa045101.04748992
64Prion diseases_Homo sapiens_hsa050201.04704290
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03857752
66Circadian entrainment_Homo sapiens_hsa047131.03606036
67Ether lipid metabolism_Homo sapiens_hsa005651.03385494
68Histidine metabolism_Homo sapiens_hsa003401.01828908
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01669060
70Fatty acid degradation_Homo sapiens_hsa000710.99446887
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98365296
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96865030
73Asthma_Homo sapiens_hsa053100.95930783
74Salmonella infection_Homo sapiens_hsa051320.95403109
75B cell receptor signaling pathway_Homo sapiens_hsa046620.94333903
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93939289
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92092573
78Hematopoietic cell lineage_Homo sapiens_hsa046400.90873410
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89553716
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89270171
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.87934090
82Measles_Homo sapiens_hsa051620.86260450
83Long-term potentiation_Homo sapiens_hsa047200.85962793
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85620311
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85512497
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85445333
87Cardiac muscle contraction_Homo sapiens_hsa042600.85044228
88Insulin secretion_Homo sapiens_hsa049110.84373473
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83941588
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.83639269
91Butanoate metabolism_Homo sapiens_hsa006500.82584171
92Osteoclast differentiation_Homo sapiens_hsa043800.81525567
93Olfactory transduction_Homo sapiens_hsa047400.80925734
94Chemokine signaling pathway_Homo sapiens_hsa040620.80405796
95Dopaminergic synapse_Homo sapiens_hsa047280.80402906
96Endocytosis_Homo sapiens_hsa041440.79606901
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79499815
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78149559
99Phenylalanine metabolism_Homo sapiens_hsa003600.77637121
100Folate biosynthesis_Homo sapiens_hsa007900.77564996
101African trypanosomiasis_Homo sapiens_hsa051430.77336768
102Salivary secretion_Homo sapiens_hsa049700.77324184
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76325982
104cAMP signaling pathway_Homo sapiens_hsa040240.76205853
105Taste transduction_Homo sapiens_hsa047420.75570105
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74915170
107Lysosome_Homo sapiens_hsa041420.74908086
108Arginine biosynthesis_Homo sapiens_hsa002200.74505630
109Shigellosis_Homo sapiens_hsa051310.74171005
110Axon guidance_Homo sapiens_hsa043600.73942778
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73889456
112Calcium signaling pathway_Homo sapiens_hsa040200.72736128
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68936352
114Sphingolipid metabolism_Homo sapiens_hsa006000.68829406
115Cholinergic synapse_Homo sapiens_hsa047250.68506019
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67417299
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.67330163
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66961529
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66635350
120Gastric acid secretion_Homo sapiens_hsa049710.66270176
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63449974
122Proteoglycans in cancer_Homo sapiens_hsa052050.61758472
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.61676765
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60653243
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60645752
126Viral myocarditis_Homo sapiens_hsa054160.60038839
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59238040
128Bile secretion_Homo sapiens_hsa049760.58848254
129Protein digestion and absorption_Homo sapiens_hsa049740.58062068
130Renin secretion_Homo sapiens_hsa049240.57846647
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56770454
132Oocyte meiosis_Homo sapiens_hsa041140.56518412
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.56068083
134Melanogenesis_Homo sapiens_hsa049160.55440154
135Antigen processing and presentation_Homo sapiens_hsa046120.55153342
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54589700
137T cell receptor signaling pathway_Homo sapiens_hsa046600.54528182
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54357717
139Glioma_Homo sapiens_hsa052140.53782442
140Influenza A_Homo sapiens_hsa051640.52990921
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52466427
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52329856
143Dilated cardiomyopathy_Homo sapiens_hsa054140.52243997
144Caffeine metabolism_Homo sapiens_hsa002320.52022770
145Oxytocin signaling pathway_Homo sapiens_hsa049210.50203404
146Adherens junction_Homo sapiens_hsa045200.48538730
147Other glycan degradation_Homo sapiens_hsa005110.48506269
148Retinol metabolism_Homo sapiens_hsa008300.48301766
149Phototransduction_Homo sapiens_hsa047440.48108171
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47483616
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46818129
152Amphetamine addiction_Homo sapiens_hsa050310.46356718
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45761127
154Platelet activation_Homo sapiens_hsa046110.44798175
155Sulfur relay system_Homo sapiens_hsa041220.44564374
156Gap junction_Homo sapiens_hsa045400.43111914
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43023166
158Chemical carcinogenesis_Homo sapiens_hsa052040.42984135
159Regulation of autophagy_Homo sapiens_hsa041400.42947171
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42944283
161Peroxisome_Homo sapiens_hsa041460.42530841
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38961926
163Ras signaling pathway_Homo sapiens_hsa040140.37160733
164Non-homologous end-joining_Homo sapiens_hsa034500.36891435
165Hepatitis B_Homo sapiens_hsa051610.36844783
166Homologous recombination_Homo sapiens_hsa034400.36186723
167Legionellosis_Homo sapiens_hsa051340.34170597
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.33705828

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