FAM69B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.86757314
2synaptic vesicle maturation (GO:0016188)5.33999710
3ribosomal small subunit biogenesis (GO:0042274)5.26153580
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93098796
5synaptic vesicle exocytosis (GO:0016079)4.82579573
6regulation of synapse structural plasticity (GO:0051823)4.79540597
7lymph vessel development (GO:0001945)4.78705897
8vocalization behavior (GO:0071625)4.70102721
9locomotory exploration behavior (GO:0035641)4.68219461
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.65770718
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59758487
12viral transcription (GO:0019083)4.58192317
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45814128
14neuronal action potential propagation (GO:0019227)4.43535295
15translational termination (GO:0006415)4.25763197
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.22415338
17protein localization to synapse (GO:0035418)4.21562877
18regulation of glutamate receptor signaling pathway (GO:1900449)4.19109290
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.13083007
20neuron cell-cell adhesion (GO:0007158)4.07401508
21glutamate secretion (GO:0014047)4.06622897
22exploration behavior (GO:0035640)4.01797651
23regulation of synaptic vesicle exocytosis (GO:2000300)3.97413713
24neurotransmitter secretion (GO:0007269)3.88300909
25protein-DNA complex disassembly (GO:0032986)3.80750631
26nucleosome disassembly (GO:0006337)3.80750631
27translational elongation (GO:0006414)3.78479947
28regulation of synaptic vesicle transport (GO:1902803)3.75123573
29platelet dense granule organization (GO:0060155)3.72269801
30negative regulation of microtubule polymerization (GO:0031115)3.69808931
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.68268086
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67645109
33DNA deamination (GO:0045006)3.63143154
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.62971339
35embryonic heart tube development (GO:0035050)3.55957734
36layer formation in cerebral cortex (GO:0021819)3.53825324
37negative regulation of erythrocyte differentiation (GO:0045647)3.53496163
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53076810
39regulation of neuronal synaptic plasticity (GO:0048168)3.49278018
40synaptic transmission, glutamatergic (GO:0035249)3.46560614
41negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.46321955
42pyrimidine nucleotide catabolic process (GO:0006244)3.45215116
43postsynaptic membrane organization (GO:0001941)3.44247853
44positive regulation of membrane potential (GO:0045838)3.44150528
45positive regulation of synapse maturation (GO:0090129)3.42035435
46blood vessel maturation (GO:0001955)3.40197290
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37288640
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36450820
49chaperone-mediated protein transport (GO:0072321)3.36250724
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35513487
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31907128
52glutamate receptor signaling pathway (GO:0007215)3.29788073
53activation of protein kinase A activity (GO:0034199)3.29562548
54maturation of SSU-rRNA (GO:0030490)3.27499688
55metallo-sulfur cluster assembly (GO:0031163)3.27186675
56iron-sulfur cluster assembly (GO:0016226)3.27186675
57protein complex disassembly (GO:0043241)3.27052263
58viral life cycle (GO:0019058)3.25643892
59positive regulation of protein kinase C signaling (GO:0090037)3.23330571
60cellular protein complex disassembly (GO:0043624)3.22305668
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21921219
62neuromuscular process controlling posture (GO:0050884)3.21283782
63cranial nerve morphogenesis (GO:0021602)3.20751818
64definitive hemopoiesis (GO:0060216)3.18079451
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17937818
66antigen processing and presentation via MHC class Ib (GO:0002475)3.17045077
67neuron-neuron synaptic transmission (GO:0007270)3.17000579
68L-serine metabolic process (GO:0006563)3.16644163
69heterochromatin organization (GO:0070828)3.15389134
70rRNA transcription (GO:0009303)3.08501749
71histone arginine methylation (GO:0034969)3.07065705
72long-term memory (GO:0007616)3.06314809
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05549545
74positive regulation of neurotransmitter secretion (GO:0001956)3.04390050
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04276408
76UTP biosynthetic process (GO:0006228)3.03203671
77cell communication by electrical coupling (GO:0010644)3.02444863
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02131533
79dendritic spine morphogenesis (GO:0060997)3.01970446
80proline transport (GO:0015824)3.01676325
81aggressive behavior (GO:0002118)3.00414052
82macromolecular complex disassembly (GO:0032984)2.99581944
83mitochondrion transport along microtubule (GO:0047497)2.98696376
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98696376
85positive regulation of neurotransmitter transport (GO:0051590)2.98024710
86negative regulation of Notch signaling pathway (GO:0045746)2.97723633
87neurotransmitter transport (GO:0006836)2.97252630
88negative regulation of cell size (GO:0045792)2.96668838
89proline biosynthetic process (GO:0006561)2.93580641
90cotranslational protein targeting to membrane (GO:0006613)2.91671544
91cell migration in hindbrain (GO:0021535)2.91234298
92lymphoid progenitor cell differentiation (GO:0002320)2.90325266
93protein targeting to ER (GO:0045047)2.90265174
94ribosomal small subunit assembly (GO:0000028)2.89492832
95regulation of neurotransmitter levels (GO:0001505)2.88868851
96DNA strand renaturation (GO:0000733)2.88367824
97regulation of postsynaptic membrane potential (GO:0060078)2.87950324
98pseudouridine synthesis (GO:0001522)2.86996916
99translational initiation (GO:0006413)2.85894248
100ribonucleoprotein complex biogenesis (GO:0022613)2.85583173
101regulation of female receptivity (GO:0045924)2.85568833
102response to pheromone (GO:0019236)2.84555288
103chromatin assembly (GO:0031497)2.84519338
104regulation of respiratory system process (GO:0044065)2.82140561
105regulation of protein kinase A signaling (GO:0010738)2.81634390
106respiratory system process (GO:0003016)2.81546054
107pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81485139
108positive regulation of dendritic spine development (GO:0060999)2.80947478
109sodium ion export (GO:0071436)2.80286344
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80124566
111axon cargo transport (GO:0008088)2.79966546
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79861766
113neuron recognition (GO:0008038)2.79748164
114auditory behavior (GO:0031223)2.79534969
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77171226
116UTP metabolic process (GO:0046051)2.76862370
117peptidyl-arginine methylation (GO:0018216)2.76446672
118peptidyl-arginine N-methylation (GO:0035246)2.76446672
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75314530
120protein localization to endoplasmic reticulum (GO:0070972)2.75083304
121thyroid gland development (GO:0030878)2.75065873
122neurotransmitter-gated ion channel clustering (GO:0072578)2.74896704
123regulation of translational fidelity (GO:0006450)2.74881542
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74749875
125membrane depolarization during action potential (GO:0086010)2.71713160
126regulation of respiratory gaseous exchange (GO:0043576)2.71049902
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70252496
128microtubule severing (GO:0051013)2.68505157
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.68412060
130establishment of mitochondrion localization (GO:0051654)2.67655966
131regulation of neurotransmitter secretion (GO:0046928)2.67175036
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66683859
133membrane hyperpolarization (GO:0060081)2.65292891
134neuron remodeling (GO:0016322)2.65226829
135pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65193344
136lymphangiogenesis (GO:0001946)2.65176101
137regulation of vesicle fusion (GO:0031338)2.64972003
138response to auditory stimulus (GO:0010996)2.64563216
139grooming behavior (GO:0007625)2.64546408
140heart valve formation (GO:0003188)2.64265007
141membrane depolarization (GO:0051899)2.64230653
142GTP biosynthetic process (GO:0006183)2.63920957
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63709436
144cerebellar Purkinje cell differentiation (GO:0021702)2.63541000
145gamma-aminobutyric acid transport (GO:0015812)2.63518316
146pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63218839
147melanin biosynthetic process (GO:0042438)2.62881808
148mechanosensory behavior (GO:0007638)2.62655333
149UV protection (GO:0009650)2.62307145
150transmission of nerve impulse (GO:0019226)2.61234454
151cellular potassium ion homeostasis (GO:0030007)2.61219304
152female mating behavior (GO:0060180)2.61194618
153synaptic vesicle transport (GO:0048489)2.61120654
154establishment of synaptic vesicle localization (GO:0097480)2.61120654
155neuromuscular process controlling balance (GO:0050885)2.59112117
156pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58714483
157inositol phosphate catabolic process (GO:0071545)2.57724783
158regulation of synaptic plasticity (GO:0048167)2.57489900
159gamma-aminobutyric acid signaling pathway (GO:0007214)2.57138569
160base-excision repair, AP site formation (GO:0006285)2.56658860
161deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56453639
162neuronal ion channel clustering (GO:0045161)2.56279990
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.55769136
164regulation of synapse maturation (GO:0090128)2.55700809
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.54243022
166endosome to pigment granule transport (GO:0043485)2.53797351
167endosome to melanosome transport (GO:0035646)2.53797351
168dopamine receptor signaling pathway (GO:0007212)2.53104551
169peptidyl-arginine omega-N-methylation (GO:0035247)2.52497802
170CTP biosynthetic process (GO:0006241)2.52478604
171CTP metabolic process (GO:0046036)2.52478604
172regulation of synaptic transmission, glutamatergic (GO:0051966)2.52478279
173regulation of neurotransmitter transport (GO:0051588)2.52219412
174axonal fasciculation (GO:0007413)2.52074016
175pentose metabolic process (GO:0019321)2.49715067
176guanosine-containing compound biosynthetic process (GO:1901070)2.48912289
177neural tube development (GO:0021915)2.47537441
178adenosine receptor signaling pathway (GO:0001973)2.47162829
179establishment of protein localization to mitochondrial membrane (GO:0090151)2.46461397
180outer ear morphogenesis (GO:0042473)2.46460099
181cellular anion homeostasis (GO:0030002)2.45559249
182adenine nucleotide transport (GO:0051503)2.45542454
183negative regulation of blood vessel endothelial cell migration (GO:0043537)2.44781160
184positive regulation of urine volume (GO:0035810)2.39517529
185cellular component biogenesis (GO:0044085)2.39405602
186protein kinase C signaling (GO:0070528)2.38971556
187ribosomal large subunit biogenesis (GO:0042273)2.38838016
188nuclear-transcribed mRNA catabolic process (GO:0000956)2.37207632
189DNA unwinding involved in DNA replication (GO:0006268)2.35289277
190regulation of mitochondrial translation (GO:0070129)2.34233629
191apoptotic process involved in morphogenesis (GO:0060561)2.33265862
192dendritic spine organization (GO:0097061)2.32832262
193phosphatidylglycerol biosynthetic process (GO:0006655)2.31848665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.70350772
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.57968844
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.05246203
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.02497274
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.85620200
6REST_21632747_ChIP-Seq_MESCs_Mouse2.73306385
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69302036
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.60506283
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55897659
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.54911936
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44085564
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.28065746
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.25979764
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24147711
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23937383
16* P68_20966046_ChIP-Seq_HELA_Human2.16074975
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12664422
18IGF1R_20145208_ChIP-Seq_DFB_Human2.11699680
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06907754
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06340068
21SCL_19346495_ChIP-Seq_HPC-7_Human2.04085518
22GBX2_23144817_ChIP-Seq_PC3_Human2.04031596
23DROSHA_22980978_ChIP-Seq_HELA_Human2.01944336
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00463547
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99647820
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99448403
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99448403
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98964079
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95763349
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.94042608
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91118456
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87532844
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.87126581
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85739680
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85577502
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81503646
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.77442939
38ZNF274_21170338_ChIP-Seq_K562_Hela1.76303127
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75482130
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72416002
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71932595
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71663751
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.70759396
44KDM2B_26808549_Chip-Seq_DND41_Human1.66741038
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.60506427
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59760636
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.59756109
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59686863
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59029779
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56193520
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55709039
52TAF15_26573619_Chip-Seq_HEK293_Human1.54889754
53MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.54167258
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53194232
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.50367713
56E2F7_22180533_ChIP-Seq_HELA_Human1.49913381
57MYC_22102868_ChIP-Seq_BL_Human1.49307806
58VDR_21846776_ChIP-Seq_THP-1_Human1.49286294
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48530597
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47457961
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.47090028
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.46638457
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45863576
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45729460
65CIITA_25753668_ChIP-Seq_RAJI_Human1.43108750
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41875471
67RACK7_27058665_Chip-Seq_MCF-7_Human1.40908312
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39847507
69* SMC4_20622854_ChIP-Seq_HELA_Human1.36962668
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35978256
71TTF2_22483619_ChIP-Seq_HELA_Human1.35676402
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35608123
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.34934254
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32298629
75* PHF8_20622854_ChIP-Seq_HELA_Human1.31820688
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31155712
77CREB1_26743006_Chip-Seq_LNCaP_Human1.30868180
78GABP_19822575_ChIP-Seq_HepG2_Human1.30435519
79CTCF_21964334_Chip-Seq_Bcells_Human1.29950367
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.29725544
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27669216
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25454033
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.24960242
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23951167
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23908663
86* LXR_22292898_ChIP-Seq_THP-1_Human1.23096250
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22007114
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.21229766
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20651573
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19923698
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19819172
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.17958298
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17628723
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.16974088
95* BCOR_27268052_Chip-Seq_Bcells_Human1.16629359
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15991163
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.15292770
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15163213
99* E2F1_20622854_ChIP-Seq_HELA_Human1.14591964
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14242605
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13904960
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13607343
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13088989
104* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13058134
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13023448
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.12230106
107MAF_26560356_Chip-Seq_TH2_Human1.11452444
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.10858655
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09225627
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08338161
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08300821
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06337117
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06187130
114KDM5A_27292631_Chip-Seq_BREAST_Human1.06046939
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05768595
116NCOR1_26117541_ChIP-Seq_K562_Human1.05476493
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99094259
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98965010
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98482509
120XRN2_22483619_ChIP-Seq_HELA_Human0.97734801
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96498593
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95626326
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95459385
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95112200
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94419586
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94264027
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93461430
128* TCF7_22412390_ChIP-Seq_EML_Mouse0.93048455
129CTCF_27219007_Chip-Seq_Bcells_Human0.90682380
130* BCL6_27268052_Chip-Seq_Bcells_Human0.90093465
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.89822330
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89809904
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89656940
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.89398992
135JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88812498
136SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88631734
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88624557
138EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87835437
139CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87497604
140KDM2B_26808549_Chip-Seq_K562_Human0.87397683
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87193635
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87088789
143HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86970393
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.86862331
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85632064
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84679479
147VDR_24763502_ChIP-Seq_THP-1_Human0.83965377
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.83838438
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83464628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.82754615
2MP0003880_abnormal_central_pattern4.38647787
3MP0010368_abnormal_lymphatic_system4.32955023
4MP0003635_abnormal_synaptic_transmissio3.81159580
5MP0001968_abnormal_touch/_nociception3.05310404
6MP0009745_abnormal_behavioral_response3.01857005
7MP0002063_abnormal_learning/memory/cond2.86721097
8MP0004270_analgesia2.83541158
9MP0001879_abnormal_lymphatic_vessel2.82930803
10MP0002064_seizures2.63191899
11MP0002736_abnormal_nociception_after2.58842230
12MP0005423_abnormal_somatic_nervous2.57722710
13MP0009046_muscle_twitch2.56438669
14MP0002272_abnormal_nervous_system2.41944569
15MP0002249_abnormal_larynx_morphology2.36885145
16MP0003136_yellow_coat_color2.36066578
17MP0002572_abnormal_emotion/affect_behav2.35888335
18MP0010030_abnormal_orbit_morphology2.29498556
19MP0003123_paternal_imprinting2.25349418
20MP0002734_abnormal_mechanical_nocicepti2.17525797
21MP0001529_abnormal_vocalization2.17143735
22MP0002735_abnormal_chemical_nociception2.12905273
23MP0009278_abnormal_bone_marrow2.11179247
24MP0006276_abnormal_autonomic_nervous2.10421978
25MP0008569_lethality_at_weaning2.09939131
26MP0002733_abnormal_thermal_nociception2.06344184
27MP0002822_catalepsy1.98329402
28MP0000537_abnormal_urethra_morphology1.98289101
29MP0000049_abnormal_middle_ear1.98221213
30MP0002909_abnormal_adrenal_gland1.96496660
31MP0001970_abnormal_pain_threshold1.91706153
32MP0002184_abnormal_innervation1.89063841
33MP0004142_abnormal_muscle_tone1.89029776
34MP0002653_abnormal_ependyma_morphology1.88721915
35MP0001486_abnormal_startle_reflex1.88162883
36MP0001501_abnormal_sleep_pattern1.86783818
37MP0002067_abnormal_sensory_capabilities1.86314955
38MP0000751_myopathy1.86022927
39MP0002396_abnormal_hematopoietic_system1.83198119
40MP0004811_abnormal_neuron_physiology1.80899680
41MP0000678_abnormal_parathyroid_gland1.71589344
42MP0002557_abnormal_social/conspecific_i1.71286258
43MP0005174_abnormal_tail_pigmentation1.62526174
44MP0005386_behavior/neurological_phenoty1.61598106
45MP0004924_abnormal_behavior1.61598106
46MP0002160_abnormal_reproductive_system1.60992477
47MP0001440_abnormal_grooming_behavior1.60885398
48MP0003111_abnormal_nucleus_morphology1.59906624
49MP0001188_hyperpigmentation1.59444556
50MP0000955_abnormal_spinal_cord1.58117362
51MP0004858_abnormal_nervous_system1.53704452
52MP0003646_muscle_fatigue1.49298299
53MP0001905_abnormal_dopamine_level1.45820474
54MP0005670_abnormal_white_adipose1.42177389
55MP0000465_gastrointestinal_hemorrhage1.41959662
56MP0001984_abnormal_olfaction1.40322496
57MP0004185_abnormal_adipocyte_glucose1.39159768
58MP0003879_abnormal_hair_cell1.35705329
59MP0005409_darkened_coat_color1.34837501
60MP0001293_anophthalmia1.34229409
61MP0000778_abnormal_nervous_system1.34187181
62MP0002638_abnormal_pupillary_reflex1.32859494
63MP0003385_abnormal_body_wall1.31662924
64MP0005167_abnormal_blood-brain_barrier1.29011388
65MP0003122_maternal_imprinting1.26922058
66MP0002066_abnormal_motor_capabilities/c1.24769646
67MP0005646_abnormal_pituitary_gland1.24579467
68MP0004145_abnormal_muscle_electrophysio1.24148596
69MP0003329_amyloid_beta_deposits1.21503307
70MP0000003_abnormal_adipose_tissue1.20495363
71MP0002882_abnormal_neuron_morphology1.19284852
72MP0005623_abnormal_meninges_morphology1.19186285
73MP0002932_abnormal_joint_morphology1.18578986
74MP0003693_abnormal_embryo_hatching1.18437577
75MP0001502_abnormal_circadian_rhythm1.16504267
76MP0003172_abnormal_lysosome_physiology1.16161062
77MP0005645_abnormal_hypothalamus_physiol1.16085081
78MP0002095_abnormal_skin_pigmentation1.14668177
79MP0003121_genomic_imprinting1.13909854
80MP0005171_absent_coat_pigmentation1.12931815
81MP0003315_abnormal_perineum_morphology1.12551890
82MP0002837_dystrophic_cardiac_calcinosis1.11132294
83MP0002089_abnormal_postnatal_growth/wei1.10126180
84MP0009379_abnormal_foot_pigmentation1.09269223
85MP0008932_abnormal_embryonic_tissue1.09207344
86MP0003567_abnormal_fetal_cardiomyocyte1.07888620
87MP0004215_abnormal_myocardial_fiber1.07539954
88MP0005666_abnormal_adipose_tissue1.05550306
89MP0008961_abnormal_basal_metabolism1.01379222
90MP0001672_abnormal_embryogenesis/_devel1.00969412
91MP0005380_embryogenesis_phenotype1.00969412
92MP0000015_abnormal_ear_pigmentation1.00313540
93MP0004272_abnormal_basement_membrane0.99766074
94MP0004147_increased_porphyrin_level0.99356694
95MP0003942_abnormal_urinary_system0.98425875
96MP0000631_abnormal_neuroendocrine_gland0.98096134
97MP0000516_abnormal_urinary_system0.96712121
98MP0005367_renal/urinary_system_phenotyp0.96712121
99MP0003137_abnormal_impulse_conducting0.96653057
100MP0002152_abnormal_brain_morphology0.96618666
101MP0006292_abnormal_olfactory_placode0.96565102
102MP0003861_abnormal_nervous_system0.96437869
103MP0004808_abnormal_hematopoietic_stem0.95677789
104MP0005375_adipose_tissue_phenotype0.95471648
105MP0002697_abnormal_eye_size0.94425999
106MP0003984_embryonic_growth_retardation0.93869714
107MP0008872_abnormal_physiological_respon0.93811866
108MP0003633_abnormal_nervous_system0.93705776
109MP0010094_abnormal_chromosome_stability0.92452040
110MP0003119_abnormal_digestive_system0.92267145
111MP0001730_embryonic_growth_arrest0.91706850
112MP0004133_heterotaxia0.91645878
113MP0003787_abnormal_imprinting0.90982402
114MP0001346_abnormal_lacrimal_gland0.90870552
115MP0003866_abnormal_defecation0.88894913
116MP0002088_abnormal_embryonic_growth/wei0.87405430
117MP0004085_abnormal_heartbeat0.87232359
118MP0004130_abnormal_muscle_cell0.85034243
119MP0001986_abnormal_taste_sensitivity0.84802104
120MP0002085_abnormal_embryonic_tissue0.84524891
121MP0005075_abnormal_melanosome_morpholog0.83450744
122MP0001849_ear_inflammation0.83400339
123MP0002234_abnormal_pharynx_morphology0.82512029
124MP0000566_synostosis0.82225717
125MP0010630_abnormal_cardiac_muscle0.82135308
126MP0005187_abnormal_penis_morphology0.82011789
127MP0001664_abnormal_digestion0.81890456
128MP0008874_decreased_physiological_sensi0.81095312
129MP0009053_abnormal_anal_canal0.80225858
130MP0003283_abnormal_digestive_organ0.80160684
131MP0002092_abnormal_eye_morphology0.79197460
132MP0009250_abnormal_appendicular_skeleto0.78538358
133MP0003935_abnormal_craniofacial_develop0.78176524
134MP0002084_abnormal_developmental_patter0.78126234
135MP0003077_abnormal_cell_cycle0.77882462
136MP0005220_abnormal_exocrine_pancreas0.76181826
137MP0002080_prenatal_lethality0.76139141
138MP0002069_abnormal_eating/drinking_beha0.75188068
139MP0002114_abnormal_axial_skeleton0.74874418
140MP0000747_muscle_weakness0.74719320
141MP0004233_abnormal_muscle_weight0.73645703
142MP0004885_abnormal_endolymph0.73575702
143MP0006035_abnormal_mitochondrial_morpho0.73048874
144MP0002925_abnormal_cardiovascular_devel0.72918257
145MP0003631_nervous_system_phenotype0.71979400
146MP0006036_abnormal_mitochondrial_physio0.71237578
147MP0005535_abnormal_body_temperature0.69672424
148MP0000681_abnormal_thyroid_gland0.67439802
149MP0002229_neurodegeneration0.66311058
150MP0005394_taste/olfaction_phenotype0.64584588
151MP0005499_abnormal_olfactory_system0.64584588
152MP0005397_hematopoietic_system_phenotyp0.63819640
153MP0001545_abnormal_hematopoietic_system0.63819640
154MP0003956_abnormal_body_size0.58924017
155MP0002752_abnormal_somatic_nervous0.58869717
156MP0002751_abnormal_autonomic_nervous0.58587365
157MP0004484_altered_response_of0.58331112
158MP0010769_abnormal_survival0.58217729
159MP0004036_abnormal_muscle_relaxation0.58040636
160MP0000372_irregular_coat_pigmentation0.57539338
161MP0010768_mortality/aging0.56797972

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.40460220
2Focal motor seizures (HP:0011153)5.36124979
3Visual hallucinations (HP:0002367)4.92369346
4Truncus arteriosus (HP:0001660)4.12003796
5Hyperthyroidism (HP:0000836)4.04325719
6Focal seizures (HP:0007359)3.86055873
7Atonic seizures (HP:0010819)3.73217907
8Reticulocytopenia (HP:0001896)3.60452719
9Broad distal phalanx of finger (HP:0009836)3.51284724
10Epileptic encephalopathy (HP:0200134)3.48207019
11Retinal dysplasia (HP:0007973)3.44265587
12Febrile seizures (HP:0002373)3.41386695
13Abnormality of the aortic arch (HP:0012303)3.34987613
14Type II lissencephaly (HP:0007260)3.23743933
15Aplastic anemia (HP:0001915)3.21337457
16Poor eye contact (HP:0000817)3.19181996
17Progressive inability to walk (HP:0002505)3.17439224
18Capillary hemangiomas (HP:0005306)3.14751693
19Mutism (HP:0002300)3.10618518
20Absence seizures (HP:0002121)3.09972083
21Papilledema (HP:0001085)3.05112707
22Lymphangioma (HP:0100764)3.03029793
23Ankle clonus (HP:0011448)3.02864568
24Depression (HP:0000716)2.97531204
25Acute lymphatic leukemia (HP:0006721)2.89260335
26Broad-based gait (HP:0002136)2.84193819
27Transposition of the great arteries (HP:0001669)2.81161025
28Abnormal connection of the cardiac segments (HP:0011545)2.81161025
29Abnormal ventriculo-arterial connection (HP:0011563)2.81161025
30Progressive cerebellar ataxia (HP:0002073)2.81056299
31Hepatocellular necrosis (HP:0001404)2.80043101
32Truncal ataxia (HP:0002078)2.79734090
33Rectovaginal fistula (HP:0000143)2.75942961
34Rectal fistula (HP:0100590)2.75942961
35Partial duplication of thumb phalanx (HP:0009944)2.74312712
36Hypothermia (HP:0002045)2.73338165
37Lissencephaly (HP:0001339)2.71255311
38Dialeptic seizures (HP:0011146)2.68937883
39Poor suck (HP:0002033)2.68148254
40Rib fusion (HP:0000902)2.65565603
41Gaze-evoked nystagmus (HP:0000640)2.65552681
42Impaired social interactions (HP:0000735)2.62786836
43Abnormal social behavior (HP:0012433)2.62786836
44Thrombocytosis (HP:0001894)2.61427522
45Intestinal fistula (HP:0100819)2.60158223
46Anxiety (HP:0000739)2.59041386
47Large eyes (HP:0001090)2.58585378
48Impaired vibration sensation in the lower limbs (HP:0002166)2.57868465
49Supranuclear gaze palsy (HP:0000605)2.54318556
50Spinal canal stenosis (HP:0003416)2.52465560
51Facial hemangioma (HP:0000329)2.48490550
52Testicular atrophy (HP:0000029)2.48029398
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47336176
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47336176
55Action tremor (HP:0002345)2.47145218
56Turricephaly (HP:0000262)2.45943005
57Double outlet right ventricle (HP:0001719)2.45282622
58Congenital malformation of the right heart (HP:0011723)2.45282622
59Amyotrophic lateral sclerosis (HP:0007354)2.44605413
60Insomnia (HP:0100785)2.43335252
61Partial duplication of the phalanx of hand (HP:0009999)2.42771940
62Bradykinesia (HP:0002067)2.42553054
63Abnormality of the 4th metacarpal (HP:0010012)2.40091354
64Focal dystonia (HP:0004373)2.39493575
65Microretrognathia (HP:0000308)2.39129153
66Vaginal fistula (HP:0004320)2.38993870
67High anterior hairline (HP:0009890)2.38358534
68Impaired smooth pursuit (HP:0007772)2.37991526
69Myotonia (HP:0002486)2.37300272
70Limb dystonia (HP:0002451)2.37120673
71Elevated erythrocyte sedimentation rate (HP:0003565)2.34560746
72Hyperacusis (HP:0010780)2.31450411
73Abnormality of the phalanges of the hallux (HP:0010057)2.29127473
74Duplication of thumb phalanx (HP:0009942)2.28024794
75Abnormal eating behavior (HP:0100738)2.25864985
76Inability to walk (HP:0002540)2.25099245
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.21271914
78Hypoplasia of the brainstem (HP:0002365)2.21271914
79Craniofacial dystonia (HP:0012179)2.21271829
80Generalized tonic-clonic seizures (HP:0002069)2.20922231
81Absent thumb (HP:0009777)2.20520313
82Urinary urgency (HP:0000012)2.18615718
83Pallor (HP:0000980)2.18373436
84Amblyopia (HP:0000646)2.17374987
85Postural instability (HP:0002172)2.17283168
86Ulnar bowing (HP:0003031)2.11781640
87Torticollis (HP:0000473)2.11426981
88Hemiparesis (HP:0001269)2.11267413
89Unsteady gait (HP:0002317)2.10772459
90Optic nerve coloboma (HP:0000588)2.09927267
91Polyphagia (HP:0002591)2.09195286
92Abnormality of ocular smooth pursuit (HP:0000617)2.07809084
93Macrocytic anemia (HP:0001972)2.07212556
94Microvesicular hepatic steatosis (HP:0001414)2.06715832
95Nonimmune hydrops fetalis (HP:0001790)2.06655328
96Stereotypic behavior (HP:0000733)2.05461214
97Scanning speech (HP:0002168)2.04165371
98Dysmetria (HP:0001310)2.03496308
99Increased muscle lipid content (HP:0009058)2.02433961
100Mitochondrial inheritance (HP:0001427)2.02099843
101Neoplasm of the adrenal cortex (HP:0100641)1.99752802
102Psychosis (HP:0000709)1.99580769
103Ragged-red muscle fibers (HP:0003200)1.99012014
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98505007
105Broad face (HP:0000283)1.98431430
106Annular pancreas (HP:0001734)1.96433759
107Dysdiadochokinesis (HP:0002075)1.96283201
108Abnormal mitochondria in muscle tissue (HP:0008316)1.95135438
109Abnormality of cells of the erythroid lineage (HP:0012130)1.94412818
110Spastic gait (HP:0002064)1.93762205
111Hepatic necrosis (HP:0002605)1.93249005
112Abnormality of the columella (HP:0009929)1.92798267
113Elfin facies (HP:0004428)1.92311874
114Self-mutilation (HP:0000742)1.91764883
115Osteomalacia (HP:0002749)1.91638207
116Diminished motivation (HP:0000745)1.90756393
117Pointed chin (HP:0000307)1.90238402
118Severe visual impairment (HP:0001141)1.89342556
119Abnormality of reticulocytes (HP:0004312)1.89334768
120Patellar aplasia (HP:0006443)1.87172807
121Cutaneous melanoma (HP:0012056)1.86987591
122Anteriorly placed anus (HP:0001545)1.86818438
123Urinary bladder sphincter dysfunction (HP:0002839)1.86732795
124Failure to thrive in infancy (HP:0001531)1.85361640
125Delusions (HP:0000746)1.85090759
126Long foot (HP:0001833)1.84478463
127Emotional lability (HP:0000712)1.84468689
128Abnormal number of erythroid precursors (HP:0012131)1.82471194
129Ventricular fibrillation (HP:0001663)1.81986388
130Abnormally folded helix (HP:0008544)1.81711208
131Dysautonomia (HP:0002459)1.81157223
132Limb ataxia (HP:0002070)1.80490668
133Neoplasm of the peripheral nervous system (HP:0100007)1.79935493
134Chronic otitis media (HP:0000389)1.79369786
135Iris hypopigmentation (HP:0007730)1.78917778
136Abnormal number of incisors (HP:0011064)1.78862540
137Menstrual irregularities (HP:0000858)1.78744578
138Bowel incontinence (HP:0002607)1.78561472
139Skull defect (HP:0001362)1.78528768
140Increased intramyocellular lipid droplets (HP:0012240)1.78167992
141Aplasia/Hypoplasia of the patella (HP:0006498)1.78157436
142Agitation (HP:0000713)1.77783734
143Macroglossia (HP:0000158)1.77609776
144Acute necrotizing encephalopathy (HP:0006965)1.77477191
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.76440974
146Abnormal EKG (HP:0003115)1.76426559
147High pitched voice (HP:0001620)1.76327915
148Generalized hypotonia (HP:0001290)1.76327344
149Hypoventilation (HP:0002791)1.76148135
150Birth length less than 3rd percentile (HP:0003561)1.75354528
151Atelectasis (HP:0100750)1.75036951
152Abnormality of cochlea (HP:0000375)1.74758263
153Abnormality of the thoracic spine (HP:0100711)1.74675534
154Preauricular pit (HP:0004467)1.74019915
155Periauricular skin pits (HP:0100277)1.74019915
156Type 2 muscle fiber atrophy (HP:0003554)1.73278533
157Abnormal large intestine physiology (HP:0012700)1.73201148
158Radial bowing (HP:0002986)1.73124710
159Overriding aorta (HP:0002623)1.72760479
160Protruding tongue (HP:0010808)1.72262868
161Rigidity (HP:0002063)1.72199933
162Hypoparathyroidism (HP:0000829)1.72137188
163Premature skin wrinkling (HP:0100678)1.71962160
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71850100
165Short 4th metacarpal (HP:0010044)1.71850100
166Thoracic kyphosis (HP:0002942)1.68931595
167Overfolded helix (HP:0000396)1.62978904
168Absent epiphyses (HP:0010577)1.61396996
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61396996
170Skin tags (HP:0010609)1.58458330
171Impulsivity (HP:0100710)1.56330484
172Squamous cell carcinoma (HP:0002860)1.55811987
173Cerebellar dysplasia (HP:0007033)1.55031453
174Abnormality of the parathyroid morphology (HP:0011766)1.54311268
175Congenital hip dislocation (HP:0001374)1.53331185
176Deep palmar crease (HP:0006191)1.52880215
177Preauricular skin tag (HP:0000384)1.52772975
178Patent foramen ovale (HP:0001655)1.52675606
179Tetralogy of Fallot (HP:0001636)1.52635185
180Absent radius (HP:0003974)1.51921387
181Atresia of the external auditory canal (HP:0000413)1.50647124
182Asymmetric growth (HP:0100555)1.49367825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.34480639
2KDR4.53892491
3TNIK3.83257084
4MAP3K123.41684302
5CDK193.38022302
6NTRK33.10893924
7MAP3K93.08278599
8SMG12.96904008
9MAP2K72.78613435
10MINK12.75655086
11FLT32.66938863
12MARK12.59504709
13BCKDK2.46858775
14MAP3K42.45178236
15KIT2.41831320
16SCYL22.15814209
17ZAK2.13554686
18DAPK12.10093446
19CAMKK12.00753767
20EPHA41.98130882
21CAMKK21.96677364
22ACVR1B1.92067010
23NTRK21.82965012
24NME21.80914000
25MUSK1.80825632
26MAPK131.72270265
27MAP2K31.65963708
28MAP2K41.63876910
29FES1.61499194
30ICK1.61105022
31KSR11.53680468
32KSR21.52759972
33CCNB11.50442990
34TGFBR11.49641710
35VRK21.45579044
36CAMK11.41279227
37SIK31.37442855
38CDC71.35601548
39CAMK1D1.34401632
40SIK21.31610788
41ARAF1.27011874
42RPS6KA21.25881906
43RAF11.21843839
44PAK61.21481188
45NEK21.19651539
46CSF1R1.17048243
47DAPK21.15994201
48RIPK41.13405175
49AURKA1.12521176
50STK161.12192156
51RPS6KC11.04754868
52RPS6KL11.04754868
53MAP3K61.03502518
54CDK51.03454166
55NTRK11.02903969
56UHMK11.02398049
57CASK1.02165913
58EEF2K1.01609764
59WEE11.00595060
60CAMK1G0.99396664
61AKT20.98993198
62MAP3K100.96269781
63CDK80.95555497
64PKN20.93222039
65RPS6KA60.90296101
66CHEK20.90117543
67PHKG10.89444628
68PHKG20.89444628
69MARK20.89237949
70RPS6KB20.88944204
71TAOK10.87903149
72TYRO30.83892250
73MATK0.83273210
74ATR0.83015670
75RET0.81801204
76PRKD20.79479563
77CDK70.79161157
78TEC0.78894599
79MTOR0.78082259
80VRK10.77255513
81GRK50.76970871
82CSNK1A1L0.76592663
83ADRBK20.76368491
84MAPK150.74837956
85SYK0.74730118
86MAPKAPK50.72592070
87CSNK1G10.72580537
88WNK40.72362011
89DYRK1B0.71461850
90MAPK120.71339772
91EPHB20.71213030
92TAF10.70702380
93CDK120.70518366
94PRKCG0.70248704
95MAPKAPK30.70107697
96BRSK10.69948282
97DYRK20.69013050
98RPS6KA50.67617031
99CDK90.65273834
100LRRK20.63486122
101BTK0.62933446
102MAP3K70.60790626
103PRKD30.60142518
104PASK0.59166686
105DAPK30.58169548
106PLK40.57815037
107MAP2K60.55472879
108PKN10.55319503
109ABL20.55123981
110MAP3K10.54819999
111MAP3K130.54817373
112PLK10.52660236
113MAP3K110.52126967
114FGFR20.50779816
115CDK180.50763326
116NEK10.50430981
117PINK10.49461506
118ILK0.49299901
119CDK20.48767638
120MAP2K20.47557478
121CSNK1G20.46611498
122BRAF0.46410113
123TESK20.46321471
124CDK11A0.45809441
125STK40.45092076
126CDK150.44454011
127CDK40.43514259
128PRKCH0.43330079
129LMTK20.41247026
130ADRBK10.40927936
131MAP3K80.40848473
132MAPK110.40708256
133IRAK20.40109286
134AKT10.40064729
135CDK140.39692492
136CAMK2A0.39543875
137CHEK10.39528192
138DYRK1A0.38348290
139CAMK40.38327683
140TNK20.38314738
141STK380.38289651
142TLK10.37794977
143MYLK0.34518725
144STK110.32400155
145PRKG20.31618779
146NME10.31143586
147PNCK0.30843521
148BMPR1B0.29709447
149TRIB30.29431583
150HIPK20.27790400
151CAMK2D0.27636696
152PDK10.27185524
153CSNK1G30.25791757
154CAMK2B0.24815798
155ZAP700.24599825
156CAMK2G0.22511824

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34484235
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94812090
3Olfactory transduction_Homo sapiens_hsa047402.65539671
4Circadian entrainment_Homo sapiens_hsa047132.51759957
5Long-term potentiation_Homo sapiens_hsa047202.40274299
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36998317
7Glutamatergic synapse_Homo sapiens_hsa047242.23017541
8GABAergic synapse_Homo sapiens_hsa047272.19983853
9Morphine addiction_Homo sapiens_hsa050322.15947697
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11244007
11Notch signaling pathway_Homo sapiens_hsa043302.10883518
12Amphetamine addiction_Homo sapiens_hsa050312.06887468
13Dopaminergic synapse_Homo sapiens_hsa047282.03447666
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80860151
15DNA replication_Homo sapiens_hsa030301.74053300
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71285365
17Cholinergic synapse_Homo sapiens_hsa047251.71127325
18Salivary secretion_Homo sapiens_hsa049701.67759800
19Biosynthesis of amino acids_Homo sapiens_hsa012301.64553917
20Basal cell carcinoma_Homo sapiens_hsa052171.64324767
21Insulin secretion_Homo sapiens_hsa049111.63371165
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58843819
23Gastric acid secretion_Homo sapiens_hsa049711.55162211
24Taste transduction_Homo sapiens_hsa047421.54503913
25Parkinsons disease_Homo sapiens_hsa050121.54243723
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53291762
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51694605
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51636375
29Calcium signaling pathway_Homo sapiens_hsa040201.51547929
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51210376
31Ribosome_Homo sapiens_hsa030101.51183397
32Oxytocin signaling pathway_Homo sapiens_hsa049211.47290816
33Cardiac muscle contraction_Homo sapiens_hsa042601.45492395
34Fanconi anemia pathway_Homo sapiens_hsa034601.45423945
35Gap junction_Homo sapiens_hsa045401.34206655
36Serotonergic synapse_Homo sapiens_hsa047261.33996097
37Long-term depression_Homo sapiens_hsa047301.33994168
38Hedgehog signaling pathway_Homo sapiens_hsa043401.31619632
39GnRH signaling pathway_Homo sapiens_hsa049121.31589434
40Cocaine addiction_Homo sapiens_hsa050301.29664218
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29251204
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28580742
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27885617
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27608815
45Oxidative phosphorylation_Homo sapiens_hsa001901.27432928
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26942196
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25154264
48Renin secretion_Homo sapiens_hsa049241.24620968
49Alcoholism_Homo sapiens_hsa050341.24562367
50Homologous recombination_Homo sapiens_hsa034401.24307532
51RNA polymerase_Homo sapiens_hsa030201.23158467
52Pentose phosphate pathway_Homo sapiens_hsa000301.16874238
53Alzheimers disease_Homo sapiens_hsa050101.14624837
54cAMP signaling pathway_Homo sapiens_hsa040241.13374767
55Mismatch repair_Homo sapiens_hsa034301.10911461
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08324712
57Oocyte meiosis_Homo sapiens_hsa041141.07855481
58Spliceosome_Homo sapiens_hsa030401.07615030
59N-Glycan biosynthesis_Homo sapiens_hsa005101.05903839
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04309905
61Lysine degradation_Homo sapiens_hsa003101.00865445
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00031456
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99024271
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96636458
65Glioma_Homo sapiens_hsa052140.95781725
66Arginine and proline metabolism_Homo sapiens_hsa003300.94679314
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.93934367
68Huntingtons disease_Homo sapiens_hsa050160.91964558
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91122643
70Estrogen signaling pathway_Homo sapiens_hsa049150.90883083
71Systemic lupus erythematosus_Homo sapiens_hsa053220.88065439
72Collecting duct acid secretion_Homo sapiens_hsa049660.87840628
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.86730853
74mRNA surveillance pathway_Homo sapiens_hsa030150.84988603
75Vitamin B6 metabolism_Homo sapiens_hsa007500.84667459
76VEGF signaling pathway_Homo sapiens_hsa043700.84361001
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84054825
78Vibrio cholerae infection_Homo sapiens_hsa051100.83010925
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.82800989
80Hippo signaling pathway_Homo sapiens_hsa043900.82320950
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82223529
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81856390
83Fatty acid elongation_Homo sapiens_hsa000620.81539424
84One carbon pool by folate_Homo sapiens_hsa006700.79460255
85RNA transport_Homo sapiens_hsa030130.79086103
86Melanogenesis_Homo sapiens_hsa049160.78890346
87Carbon metabolism_Homo sapiens_hsa012000.77363463
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.76756621
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75972151
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74618948
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73714989
92Cell cycle_Homo sapiens_hsa041100.73086911
93Wnt signaling pathway_Homo sapiens_hsa043100.71737679
94Bladder cancer_Homo sapiens_hsa052190.71558682
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70698519
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.70647666
97mTOR signaling pathway_Homo sapiens_hsa041500.70418296
98ErbB signaling pathway_Homo sapiens_hsa040120.70276451
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68671977
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68029258
101Selenocompound metabolism_Homo sapiens_hsa004500.65444935
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65250467
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64848158
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62277700
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61361148
106Chronic myeloid leukemia_Homo sapiens_hsa052200.60840515
107Thyroid cancer_Homo sapiens_hsa052160.60031925
108Inositol phosphate metabolism_Homo sapiens_hsa005620.59508241
109Non-small cell lung cancer_Homo sapiens_hsa052230.58969562
110AMPK signaling pathway_Homo sapiens_hsa041520.58921644
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58798919
112Platelet activation_Homo sapiens_hsa046110.57764376
113Colorectal cancer_Homo sapiens_hsa052100.57747604
114Pyrimidine metabolism_Homo sapiens_hsa002400.56636526
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56556976
116Purine metabolism_Homo sapiens_hsa002300.55970132
117Arginine biosynthesis_Homo sapiens_hsa002200.55263529
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54476675
119Type II diabetes mellitus_Homo sapiens_hsa049300.54349323
120B cell receptor signaling pathway_Homo sapiens_hsa046620.53405748
121Glucagon signaling pathway_Homo sapiens_hsa049220.52916667
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.51900238
123Sulfur relay system_Homo sapiens_hsa041220.50972592
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50969798
125Fructose and mannose metabolism_Homo sapiens_hsa000510.50735769
126Melanoma_Homo sapiens_hsa052180.50521408
127Ovarian steroidogenesis_Homo sapiens_hsa049130.50480419
128Axon guidance_Homo sapiens_hsa043600.50174190
129Pyruvate metabolism_Homo sapiens_hsa006200.49923232
130Pancreatic secretion_Homo sapiens_hsa049720.48554290
131Acute myeloid leukemia_Homo sapiens_hsa052210.47736881
132Base excision repair_Homo sapiens_hsa034100.47624624
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47444683
134Metabolic pathways_Homo sapiens_hsa011000.47375713
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44648838
136Dilated cardiomyopathy_Homo sapiens_hsa054140.44366234
137Type I diabetes mellitus_Homo sapiens_hsa049400.44147625
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43356021
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42839941
140Thyroid hormone synthesis_Homo sapiens_hsa049180.42694440
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.42640373
142Insulin signaling pathway_Homo sapiens_hsa049100.42564873
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41642246
144Fatty acid metabolism_Homo sapiens_hsa012120.41308932
145MAPK signaling pathway_Homo sapiens_hsa040100.40633409
146Choline metabolism in cancer_Homo sapiens_hsa052310.40427843
147Nucleotide excision repair_Homo sapiens_hsa034200.38862193
148Circadian rhythm_Homo sapiens_hsa047100.38248814
149Rap1 signaling pathway_Homo sapiens_hsa040150.37417046
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35565391
151Shigellosis_Homo sapiens_hsa051310.35438493
152Ras signaling pathway_Homo sapiens_hsa040140.33386700

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