FAM69C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.42163430
2doxorubicin metabolic process (GO:0044598)7.42163430
3daunorubicin metabolic process (GO:0044597)7.42163430
4negative regulation of astrocyte differentiation (GO:0048712)6.57455799
5positive regulation of cellular amide metabolic process (GO:0034250)5.60720634
6atrial cardiac muscle cell action potential (GO:0086014)4.73586681
7amino acid import (GO:0043090)4.65306278
8aminoglycoside antibiotic metabolic process (GO:0030647)4.62713411
9astrocyte differentiation (GO:0048708)4.62177869
10cellular response to cholesterol (GO:0071397)4.62087883
11potassium ion import (GO:0010107)4.61678399
12response to auditory stimulus (GO:0010996)4.61006913
13L-amino acid import (GO:0043092)4.56293917
14neurotransmitter-gated ion channel clustering (GO:0072578)4.51929300
15alanine transport (GO:0032328)4.48424134
16lateral sprouting from an epithelium (GO:0060601)4.41266591
17regulation of astrocyte differentiation (GO:0048710)4.39289226
18negative regulation of glial cell differentiation (GO:0045686)4.25646910
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13946789
20regulation of neurotransmitter uptake (GO:0051580)4.10616366
21chondroitin sulfate catabolic process (GO:0030207)4.10572807
22glial cell proliferation (GO:0014009)4.09589414
23regulation of beta-amyloid formation (GO:1902003)4.08278197
24dermatan sulfate metabolic process (GO:0030205)4.08138017
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.05925978
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.05723825
27locomotory exploration behavior (GO:0035641)4.00593562
28presynaptic membrane assembly (GO:0097105)3.95115465
29appendage development (GO:0048736)3.94555675
30limb development (GO:0060173)3.94555675
31neuronal action potential propagation (GO:0019227)3.89593854
32gamma-aminobutyric acid transport (GO:0015812)3.87934116
33positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.81018688
34neuron cell-cell adhesion (GO:0007158)3.80751959
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80515008
36regulation of synapse structural plasticity (GO:0051823)3.78698086
37astrocyte development (GO:0014002)3.78334137
38C4-dicarboxylate transport (GO:0015740)3.78300801
39negative regulation of oligodendrocyte differentiation (GO:0048715)3.76952472
40negative regulation of sodium ion transport (GO:0010766)3.75781817
41cellular response to sterol (GO:0036315)3.74574306
42negative regulation of smoothened signaling pathway (GO:0045879)3.71121053
43regulation of timing of cell differentiation (GO:0048505)3.71115150
44postsynaptic membrane organization (GO:0001941)3.70088353
45negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.69351194
46cardiac left ventricle morphogenesis (GO:0003214)3.69187868
47regulation of respiratory system process (GO:0044065)3.69148829
48low-density lipoprotein particle remodeling (GO:0034374)3.66406122
49cell communication by electrical coupling (GO:0010644)3.62004853
50potassium ion homeostasis (GO:0055075)3.61471957
51neuronal stem cell maintenance (GO:0097150)3.60773387
52dermatan sulfate biosynthetic process (GO:0030208)3.58683030
53axon ensheathment in central nervous system (GO:0032291)3.57887555
54central nervous system myelination (GO:0022010)3.57887555
55oligodendrocyte differentiation (GO:0048709)3.53180408
56response to gravity (GO:0009629)3.50459946
57auditory behavior (GO:0031223)3.47547907
58behavioral response to cocaine (GO:0048148)3.45351707
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.45089535
60presynaptic membrane organization (GO:0097090)3.38674631
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37924963
62regulation of phospholipid biosynthetic process (GO:0071071)3.36171431
63photoreceptor cell differentiation (GO:0046530)3.33618824
64eye photoreceptor cell differentiation (GO:0001754)3.33618824
65cellular potassium ion homeostasis (GO:0030007)3.33477014
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25482373
67regulation of development, heterochronic (GO:0040034)3.25052760
68cerebral cortex radially oriented cell migration (GO:0021799)3.24126418
69regulation of penile erection (GO:0060405)3.23312522
70vocalization behavior (GO:0071625)3.20808434
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19524541
72axonal fasciculation (GO:0007413)3.19208087
73negative regulation of gliogenesis (GO:0014014)3.18007399
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17995947
75regulation of inclusion body assembly (GO:0090083)3.17445642
76regulation of amyloid precursor protein catabolic process (GO:1902991)3.17225273
77cellular anion homeostasis (GO:0030002)3.17195617
78olfactory bulb development (GO:0021772)3.14826560
79positive regulation of synapse assembly (GO:0051965)3.07693432
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.06972202
81regulation of sensory perception of pain (GO:0051930)3.05830394
82regulation of sensory perception (GO:0051931)3.05830394
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04980402
84melanin biosynthetic process (GO:0042438)3.04328727
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03332086
86cerebral cortex neuron differentiation (GO:0021895)3.02099306
87myelination (GO:0042552)3.01322948
88secondary metabolite biosynthetic process (GO:0044550)2.96902156
89regulation of glutamate receptor signaling pathway (GO:1900449)2.96420305
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.95573136
91neuron recognition (GO:0008038)2.94725930
92glial cell differentiation (GO:0010001)2.94513015
93synaptic vesicle exocytosis (GO:0016079)2.94288173
94neuron projection regeneration (GO:0031102)2.93622707
95retinal rod cell development (GO:0046548)2.93472688
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.91655219
97membrane repolarization (GO:0086009)2.91321999
98axon ensheathment (GO:0008366)2.90868334
99ensheathment of neurons (GO:0007272)2.90868334
100positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.90167689
101glutamate secretion (GO:0014047)2.89548025
102negative regulation of inclusion body assembly (GO:0090084)2.88863791
103layer formation in cerebral cortex (GO:0021819)2.88760246
104regulation of neuronal synaptic plasticity (GO:0048168)2.88487753
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88226845
106transmission of nerve impulse (GO:0019226)2.87751101
107negative regulation of cAMP biosynthetic process (GO:0030818)2.86924475
108regulation of respiratory gaseous exchange (GO:0043576)2.86578848
109cGMP-mediated signaling (GO:0019934)2.86281177
110heart valve formation (GO:0003188)2.85471772
111negative regulation of adenylate cyclase activity (GO:0007194)2.84454130
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83287799
113response to histamine (GO:0034776)2.83169357
114synaptic transmission, glutamatergic (GO:0035249)2.82415793
115proline transport (GO:0015824)2.81990241
116prepulse inhibition (GO:0060134)2.81791757
117startle response (GO:0001964)2.81350969
118sodium ion export (GO:0071436)2.81269107
119L-serine transport (GO:0015825)2.81201184
120regulation of heat generation (GO:0031650)2.79813226
121negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.79416895
122regulation of voltage-gated calcium channel activity (GO:1901385)2.79249823
123central nervous system projection neuron axonogenesis (GO:0021952)2.78840045
124glutamate receptor signaling pathway (GO:0007215)2.78836287
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78266140
126forebrain neuron differentiation (GO:0021879)2.77489513
127cellular sodium ion homeostasis (GO:0006883)2.77376447
128long-chain fatty acid biosynthetic process (GO:0042759)2.76772148
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75935463
130behavioral defense response (GO:0002209)2.75016058
131behavioral fear response (GO:0001662)2.75016058
132negative regulation of cyclase activity (GO:0031280)2.74546954
133melanin metabolic process (GO:0006582)2.73801560
134response to cholesterol (GO:0070723)2.73359248
135neuron-neuron synaptic transmission (GO:0007270)2.73159989
136tongue development (GO:0043586)2.73059057
137exploration behavior (GO:0035640)2.72520440
138cerebellar granule cell differentiation (GO:0021707)2.71919312
139neurotransmitter uptake (GO:0001504)2.71130366
140nonmotile primary cilium assembly (GO:0035058)2.70320403
141regulation of cellular amide metabolic process (GO:0034248)2.68937446
142L-serine metabolic process (GO:0006563)2.68231050
143acidic amino acid transport (GO:0015800)2.66151908
144cell proliferation in forebrain (GO:0021846)2.63218012
145synaptic vesicle maturation (GO:0016188)2.61397613
146long-term synaptic potentiation (GO:0060291)2.61201152
147protein heterotetramerization (GO:0051290)2.61144404
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.59021226
149regulation of glial cell differentiation (GO:0045685)2.56335120
150protein localization to synapse (GO:0035418)2.55680697
151mechanosensory behavior (GO:0007638)2.53357398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24474438
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18153781
3GBX2_23144817_ChIP-Seq_PC3_Human3.10991010
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.08577958
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08452939
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06662228
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.03318736
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83296525
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83296525
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.81623926
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80961620
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68143140
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66250574
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.58097807
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43057278
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.36989884
17AR_21572438_ChIP-Seq_LNCaP_Human2.36400593
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23869543
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23177723
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21647467
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.17733717
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14251369
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11616874
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07552402
25DROSHA_22980978_ChIP-Seq_HELA_Human2.05868169
26REST_21632747_ChIP-Seq_MESCs_Mouse1.98129324
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88770112
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78509235
29RING1B_27294783_Chip-Seq_ESCs_Mouse1.77720587
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.76172745
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71798671
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64272209
33TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.62630854
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.61059155
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55158567
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.54942386
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53218424
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.51943641
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51292546
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49968254
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46686999
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44630457
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44431033
44P300_19829295_ChIP-Seq_ESCs_Human1.43955807
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43636979
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.40360637
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.40304907
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40254235
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39783314
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39632882
51SMAD4_21799915_ChIP-Seq_A2780_Human1.39465439
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36589797
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36356953
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36249711
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35081507
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.33247842
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32346034
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32209642
59AR_25329375_ChIP-Seq_VCAP_Human1.27168351
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23889062
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23233704
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22413561
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22271217
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21604963
65RXR_22108803_ChIP-Seq_LS180_Human1.20690706
66RNF2_27304074_Chip-Seq_NSC_Mouse1.19120303
67* RARB_27405468_Chip-Seq_BRAIN_Mouse1.15467881
68TP53_18474530_ChIP-ChIP_U2OS_Human1.14214343
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.13152057
70FUS_26573619_Chip-Seq_HEK293_Human1.10860526
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10834189
72TAF15_26573619_Chip-Seq_HEK293_Human1.09182726
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07590950
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07436182
75AR_19668381_ChIP-Seq_PC3_Human1.06858898
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06776595
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06442676
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.05583813
79SOX9_26525672_Chip-Seq_HEART_Mouse1.03807138
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03505736
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03410524
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03248564
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02576125
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02576125
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02172103
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01413498
87STAT3_23295773_ChIP-Seq_U87_Human1.01289387
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.98775097
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98423386
90BCAT_22108803_ChIP-Seq_LS180_Human0.98283771
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98096282
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98023001
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97291701
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96784294
95RUNX2_22187159_ChIP-Seq_PCA_Human0.96594201
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95679861
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95658623
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95179695
99* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94943809
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94927972
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94495377
102E2F1_18555785_Chip-Seq_ESCs_Mouse0.94126607
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94120521
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93599038
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.93535252
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93250425
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92177637
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.91681945
109VDR_22108803_ChIP-Seq_LS180_Human0.90840837
110JUN_21703547_ChIP-Seq_K562_Human0.90602484
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90460403
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90270181
113RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89741103
114POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88902730
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87755592
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87026385
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86482291
118TP53_16413492_ChIP-PET_HCT116_Human0.86480544
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86230609
120SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85608544
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.85185499
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85033350
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84140877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.74583202
2MP0005645_abnormal_hypothalamus_physiol3.74319588
3MP0005646_abnormal_pituitary_gland3.28704868
4MP0005423_abnormal_somatic_nervous3.16707505
5MP0004859_abnormal_synaptic_plasticity3.15993329
6MP0004858_abnormal_nervous_system3.01469610
7MP0002638_abnormal_pupillary_reflex2.94553416
8MP0001486_abnormal_startle_reflex2.72701652
9MP0000566_synostosis2.68606905
10MP0002254_reproductive_system_inflammat2.67616340
11MP0005171_absent_coat_pigmentation2.61983108
12MP0001502_abnormal_circadian_rhythm2.61649106
13MP0005377_hearing/vestibular/ear_phenot2.59921096
14MP0003878_abnormal_ear_physiology2.59921096
15MP0006292_abnormal_olfactory_placode2.54335190
16MP0003690_abnormal_glial_cell2.51687661
17MP0003880_abnormal_central_pattern2.45906485
18MP0003329_amyloid_beta_deposits2.38185674
19MP0009384_cardiac_valve_regurgitation2.31529605
20MP0004885_abnormal_endolymph2.28285365
21MP0003635_abnormal_synaptic_transmissio2.16540175
22MP0002653_abnormal_ependyma_morphology2.09349977
23MP0001984_abnormal_olfaction1.98900768
24MP0005174_abnormal_tail_pigmentation1.97451748
25MP0002063_abnormal_learning/memory/cond1.87250997
26MP0002557_abnormal_social/conspecific_i1.85294462
27MP0002572_abnormal_emotion/affect_behav1.82875659
28MP0009745_abnormal_behavioral_response1.81343477
29MP0003136_yellow_coat_color1.74982350
30MP0002064_seizures1.74013632
31MP0000778_abnormal_nervous_system1.69696634
32MP0000049_abnormal_middle_ear1.67092483
33MP0000372_irregular_coat_pigmentation1.66645224
34MP0001485_abnormal_pinna_reflex1.63689263
35MP0005551_abnormal_eye_electrophysiolog1.63553672
36MP0001440_abnormal_grooming_behavior1.56084784
37MP0009046_muscle_twitch1.53143312
38MP0003279_aneurysm1.52255110
39MP0002735_abnormal_chemical_nociception1.52224177
40MP0005248_abnormal_Harderian_gland1.51408734
41MP0002095_abnormal_skin_pigmentation1.50301649
42MP0001293_anophthalmia1.49836133
43MP0003634_abnormal_glial_cell1.49051995
44MP0000026_abnormal_inner_ear1.47668582
45MP0002089_abnormal_postnatal_growth/wei1.46626983
46MP0000920_abnormal_myelination1.44859376
47MP0002132_abnormal_respiratory_system1.43199974
48MP0002272_abnormal_nervous_system1.37907009
49MP0001529_abnormal_vocalization1.35450917
50MP0005253_abnormal_eye_physiology1.32807295
51MP0001986_abnormal_taste_sensitivity1.31446608
52MP0002184_abnormal_innervation1.31422633
53MP0005167_abnormal_blood-brain_barrier1.30295143
54MP0001968_abnormal_touch/_nociception1.29046857
55MP0001963_abnormal_hearing_physiology1.27218219
56MP0005379_endocrine/exocrine_gland_phen1.27024216
57MP0001905_abnormal_dopamine_level1.25013606
58MP0008569_lethality_at_weaning1.24736960
59MP0006072_abnormal_retinal_apoptosis1.24647787
60MP0003938_abnormal_ear_development1.23454982
61MP0002067_abnormal_sensory_capabilities1.21405618
62MP0004742_abnormal_vestibular_system1.21207176
63MP0002734_abnormal_mechanical_nocicepti1.18990999
64MP0010030_abnormal_orbit_morphology1.16549870
65MP0001501_abnormal_sleep_pattern1.15758132
66MP0003941_abnormal_skin_development1.15663283
67MP0002733_abnormal_thermal_nociception1.14694376
68MP0000569_abnormal_digit_pigmentation1.14233814
69MP0002882_abnormal_neuron_morphology1.14164366
70MP0002736_abnormal_nociception_after1.13600725
71MP0000604_amyloidosis1.12550220
72MP0009840_abnormal_foam_cell1.10704777
73MP0005503_abnormal_tendon_morphology1.08463942
74MP0000631_abnormal_neuroendocrine_gland1.07897052
75MP0004142_abnormal_muscle_tone1.06436939
76MP0002152_abnormal_brain_morphology1.05074801
77MP0004270_analgesia1.03439336
78MP0002938_white_spotting1.03323389
79MP0003075_altered_response_to1.03323045
80MP0002752_abnormal_somatic_nervous1.03153242
81MP0005386_behavior/neurological_phenoty1.01611775
82MP0004924_abnormal_behavior1.01611775
83MP0003011_delayed_dark_adaptation1.00800242
84MP0002249_abnormal_larynx_morphology0.99676479
85MP0001177_atelectasis0.98667044
86MP0004147_increased_porphyrin_level0.98466652
87MP0002127_abnormal_cardiovascular_syste0.98299620
88MP0009250_abnormal_appendicular_skeleto0.98111549
89MP0001970_abnormal_pain_threshold0.97679343
90MP0005195_abnormal_posterior_eye0.97372023
91MP0002090_abnormal_vision0.96955579
92MP0002697_abnormal_eye_size0.96330826
93MP0001348_abnormal_lacrimal_gland0.96246274
94MP0005394_taste/olfaction_phenotype0.94769150
95MP0005499_abnormal_olfactory_system0.94769150
96MP0002822_catalepsy0.94650708
97MP0001299_abnormal_eye_distance/0.93225470
98MP0003787_abnormal_imprinting0.93224968
99MP0002909_abnormal_adrenal_gland0.91748635
100MP0003632_abnormal_nervous_system0.89941312
101MP0004811_abnormal_neuron_physiology0.89463807
102MP0008789_abnormal_olfactory_epithelium0.88231351
103MP0006276_abnormal_autonomic_nervous0.87829926
104MP0003633_abnormal_nervous_system0.87257478
105MP0003137_abnormal_impulse_conducting0.86903367
106MP0002092_abnormal_eye_morphology0.85991124
107MP0003942_abnormal_urinary_system0.85658805
108MP0002229_neurodegeneration0.85147540
109MP0000955_abnormal_spinal_cord0.84752053
110MP0003631_nervous_system_phenotype0.83790999
111MP0004134_abnormal_chest_morphology0.83735720
112MP0002066_abnormal_motor_capabilities/c0.83089553
113MP0000428_abnormal_craniofacial_morphol0.82143309
114MP0002233_abnormal_nose_morphology0.81831839
115MP0003638_abnormal_response/metabolism_0.81370295
116MP0000534_abnormal_ureter_morphology0.80856837
117MP0003937_abnormal_limbs/digits/tail_de0.80610182
118MP0005391_vision/eye_phenotype0.79993139
119MP0003122_maternal_imprinting0.79631108
120MP0009780_abnormal_chondrocyte_physiolo0.78944157
121MP0005647_abnormal_sex_gland0.78518429
122MP0003755_abnormal_palate_morphology0.77818469
123MP0001324_abnormal_eye_pigmentation0.77632822
124MP0005257_abnormal_intraocular_pressure0.73350274
125MP0003879_abnormal_hair_cell0.72342806
126MP0003861_abnormal_nervous_system0.71377406
127MP0000579_abnormal_nail_morphology0.70898911
128MP0005408_hypopigmentation0.70779757

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)6.15346466
2Aplasia involving bones of the upper limbs (HP:0009823)5.76432865
3Aplasia of the phalanges of the hand (HP:0009802)5.76432865
4Aplasia involving bones of the extremities (HP:0009825)5.76432865
5Missing ribs (HP:0000921)4.29097364
6Anophthalmia (HP:0000528)4.10168325
7Action tremor (HP:0002345)3.88702284
811 pairs of ribs (HP:0000878)3.80762024
9Synostosis involving the elbow (HP:0003938)3.72204169
10Humeroradial synostosis (HP:0003041)3.72204169
11Neurofibrillary tangles (HP:0002185)3.57796967
12Rib fusion (HP:0000902)3.56729443
13Recurrent corneal erosions (HP:0000495)3.56703937
14Peripheral hypomyelination (HP:0007182)3.56416807
15Hemiparesis (HP:0001269)3.49406318
16Morphological abnormality of the inner ear (HP:0011390)3.43329692
17Abnormality of the axillary hair (HP:0100134)3.41902404
18Abnormality of secondary sexual hair (HP:0009888)3.41902404
19Absent hair (HP:0002298)3.39145599
20Mixed hearing impairment (HP:0000410)3.11638319
21Focal seizures (HP:0007359)3.11453022
22Follicular hyperkeratosis (HP:0007502)3.10525725
23Back pain (HP:0003418)3.09309550
24Abnormality of the diencephalon (HP:0010662)3.03942510
25Hypoplastic left heart (HP:0004383)2.91924651
26Fibular hypoplasia (HP:0003038)2.87172031
27Focal motor seizures (HP:0011153)2.86222907
28Diplopia (HP:0000651)2.85512385
29Abnormality of binocular vision (HP:0011514)2.85512385
30Progressive cerebellar ataxia (HP:0002073)2.83805905
31Hyperventilation (HP:0002883)2.82205654
32Absent eyelashes (HP:0000561)2.79937590
33Absent/shortened dynein arms (HP:0200106)2.75611370
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.75611370
35Atonic seizures (HP:0010819)2.72166409
36Fibular aplasia (HP:0002990)2.68350953
37Epileptic encephalopathy (HP:0200134)2.68124089
38Abnormality of the 4th metacarpal (HP:0010012)2.67181645
39Blue irides (HP:0000635)2.65446607
40Parakeratosis (HP:0001036)2.65075148
41Long nose (HP:0003189)2.58331352
42Febrile seizures (HP:0002373)2.53763370
43Hemiplegia (HP:0002301)2.52245211
44Cerebral inclusion bodies (HP:0100314)2.50409143
45Sclerocornea (HP:0000647)2.50121716
46Abnormality of the dental pulp (HP:0006479)2.48584053
47Clumsiness (HP:0002312)2.48517475
48Coronal craniosynostosis (HP:0004440)2.43470486
49Synostosis of carpal bones (HP:0005048)2.43387353
50Split foot (HP:0001839)2.43336562
51Partial duplication of thumb phalanx (HP:0009944)2.41941070
52Alacrima (HP:0000522)2.40827892
53Hypoplastic heart (HP:0001961)2.40357441
54Cutaneous syndactyly (HP:0012725)2.37583684
55Broad alveolar ridges (HP:0000187)2.35776760
56Hypoplastic pelvis (HP:0008839)2.32378370
57Generalized tonic-clonic seizures (HP:0002069)2.32026629
58Aplasia/Hypoplasia of the clavicles (HP:0006710)2.31821368
59Morphological abnormality of the middle ear (HP:0008609)2.31480420
60Myokymia (HP:0002411)2.31076883
61Abnormal auditory evoked potentials (HP:0006958)2.30543726
62Abnormality of permanent molar morphology (HP:0011071)2.30389591
63Abnormality of the dental root (HP:0006486)2.30389591
64Taurodontia (HP:0000679)2.30389591
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30385427
66Adactyly (HP:0009776)2.30095842
67Abnormality of molar (HP:0011077)2.27369382
68Abnormality of molar morphology (HP:0011070)2.27369382
69Adrenal hypoplasia (HP:0000835)2.26615940
70Abnormality of the middle phalanges of the toes (HP:0010183)2.25977526
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22629622
72Abnormality of cochlea (HP:0000375)2.19845334
73Septo-optic dysplasia (HP:0100842)2.17669301
74Renal dysplasia (HP:0000110)2.17323927
75True hermaphroditism (HP:0010459)2.15947033
76Increased circulating renin level (HP:0000848)2.15679378
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.14349918
78Hypoplasia of the fovea (HP:0007750)2.14349918
79Polyphagia (HP:0002591)2.12037940
80Abnormal ciliary motility (HP:0012262)2.10290575
81Partial duplication of the phalanx of hand (HP:0009999)2.10257504
82Symphalangism affecting the phalanges of the hand (HP:0009773)2.09075905
83Duplication of thumb phalanx (HP:0009942)2.07848602
84Narrow nasal bridge (HP:0000446)2.06514244
85Anosmia (HP:0000458)2.05578083
86Hypoplasia of the iris (HP:0007676)2.05370396
87Unilateral renal agenesis (HP:0000122)2.04591718
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.04483655
89Dysdiadochokinesis (HP:0002075)2.03336459
90Abnormality of the nasal septum (HP:0000419)2.02187842
91Absence seizures (HP:0002121)2.01113732
92Retinal dysplasia (HP:0007973)1.98355429
93Abolished electroretinogram (ERG) (HP:0000550)1.97516658
94Abnormality of the ischium (HP:0003174)1.97503984
95Ulnar claw (HP:0001178)1.94335314
96Abnormality of the fovea (HP:0000493)1.93609983
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93277326
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.93277326
99Dialeptic seizures (HP:0011146)1.92707080
100Decreased lacrimation (HP:0000633)1.91682307
101Short hallux (HP:0010109)1.91644444
102Absent eyebrow (HP:0002223)1.91520512
103Midline defect of the nose (HP:0004122)1.91371952
104Gastrointestinal atresia (HP:0002589)1.91219003
105Oligodactyly (hands) (HP:0001180)1.90638307
106Cutaneous finger syndactyly (HP:0010554)1.90422268
107Heterochromia iridis (HP:0001100)1.90205741
108Abnormality of the antihelix (HP:0009738)1.90136957
109Conical tooth (HP:0000698)1.89346612
110Abnormal eating behavior (HP:0100738)1.89088405
111Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88512742
112Pancreatic fibrosis (HP:0100732)1.88140410
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.87697130
114Large for gestational age (HP:0001520)1.87338701
115Pseudobulbar signs (HP:0002200)1.86953061
116Abnormality of incisor morphology (HP:0011063)1.85295498
117Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84840857
118Vertebral hypoplasia (HP:0008417)1.84840857
119Esophageal atresia (HP:0002032)1.84754817
120Optic nerve hypoplasia (HP:0000609)1.83789808
121Short clavicles (HP:0000894)1.80955853
122Medial flaring of the eyebrow (HP:0010747)1.80744943
123Intention tremor (HP:0002080)1.80648592
124Vitreoretinal degeneration (HP:0000655)1.80322381
125Occipital encephalocele (HP:0002085)1.79068464
126Abnormality of the corticospinal tract (HP:0002492)1.79037659
127Neonatal short-limb short stature (HP:0008921)1.78467360
128Hypopigmentation of the fundus (HP:0007894)1.76945934
129Abnormality of midbrain morphology (HP:0002418)1.75132609
130Molar tooth sign on MRI (HP:0002419)1.75132609
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.74574480
132Limb dystonia (HP:0002451)1.73347307
133Oligodactyly (HP:0012165)1.72737681
134White forelock (HP:0002211)1.71585694
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71258103
136Abnormality of the phalanges of the 5th finger (HP:0004213)1.70227309
137Abnormality of the lacrimal duct (HP:0011481)1.69730517
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.68750835
139Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68355135
140Gait imbalance (HP:0002141)1.66883217
141Patchy hypopigmentation of hair (HP:0011365)1.66459548
142Hypoplasia of the ulna (HP:0003022)1.66340010
143Postaxial hand polydactyly (HP:0001162)1.65976188
144Preaxial foot polydactyly (HP:0001841)1.65842230
145Ankle clonus (HP:0011448)1.64961646
146Ocular albinism (HP:0001107)1.64710699
147Absent septum pellucidum (HP:0001331)1.64379479
148Tracheomalacia (HP:0002779)1.62037847
149Truncal ataxia (HP:0002078)1.61863892
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.61468208
151Median cleft lip (HP:0000161)1.61456226
152Status epilepticus (HP:0002133)1.61193306
153Hypoplastic ilia (HP:0000946)1.60685450
154Postaxial foot polydactyly (HP:0001830)1.60535478
155Postural tremor (HP:0002174)1.60442427
156Broad hallux (HP:0010055)1.60178038
157Aqueductal stenosis (HP:0002410)1.60047401
158Myelomeningocele (HP:0002475)1.58541588
159Broad toe (HP:0001837)1.58368552
160Nephrogenic diabetes insipidus (HP:0009806)1.58194307
161Nasolacrimal duct obstruction (HP:0000579)1.57715298
162Maternal diabetes (HP:0009800)1.57589454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.60106422
2LMTK24.52476778
3PRPF4B4.38279397
4NTRK23.84791057
5CASK3.65595207
6PNCK3.64507896
7PHKG13.53847492
8PHKG23.53847492
9SIK13.16944514
10MAPK153.15499689
11NTRK33.00584476
12PIK3CA2.83959918
13TNIK2.70067838
14SIK32.37787937
15SGK22.35761095
16MUSK2.19380009
17SGK4942.09967957
18SGK2232.09967957
19PRKD31.84033757
20MAPK131.77179974
21WEE11.76663247
22SIK21.61761921
23SGK31.59816251
24LATS11.57932081
25MAP2K71.54222196
26MARK11.52937597
27TSSK61.41846055
28CAMK2B1.37730939
29DDR21.27661673
30TAOK21.27491110
31CAMK2D1.23141619
32STK391.22292954
33CAMK2G1.16690692
34FGR1.16281449
35ICK1.13938369
36WNK41.11872178
37TIE11.06506078
38CAMK1G1.06461255
39CDK31.06257095
40CSNK1G21.02077493
41MINK11.01611942
42CDK191.01150745
43MAPK120.98472617
44EPHA20.97386051
45INSRR0.96272643
46MAP2K40.92752466
47MAPKAPK50.89049465
48NEK60.86635143
49STK380.86562390
50PRKCG0.85925358
51CDK50.84079229
52ADRBK20.83164219
53DYRK1A0.81574523
54EPHB20.78130438
55PDGFRA0.76992279
56PBK0.76856345
57CAMK1D0.74437387
58MAP3K40.74128197
59MAPK70.68877450
60ERBB30.68149131
61CAMK2A0.66166144
62SGK10.65692901
63ERBB40.63919815
64PRKCE0.63525930
65IRAK20.62791096
66ADRBK10.62046909
67STK110.62019353
68PINK10.61875148
69LRRK20.59750752
70PLK20.59124520
71ROCK10.58572295
72LATS20.57728979
73CSNK1G10.57175209
74CAMK10.56675781
75MARK30.56126817
76YES10.55956670
77CDC70.53810572
78CSNK1A1L0.52339320
79CSNK1G30.51424722
80KSR10.51047084
81WNK30.48319367
82BMPR1B0.48299431
83PRKD10.46993369
84CDK11A0.44720172
85CDK140.44529420
86DMPK0.44431093
87TNK20.44194986
88PKN10.42741844
89PRKCH0.42295700
90GRK50.42001949
91GRK60.41487457
92DAPK20.40367842
93MARK20.40358537
94MAP3K90.39761706
95TYRO30.39251358
96BMPR20.39143295
97PTK2B0.39058806
98FRK0.38154179
99BRSK10.37911793
100RET0.36111517
101NTRK10.36007573
102DYRK20.35776699
103VRK10.35750380
104AKT30.35670274
105FGFR10.35591738
106CLK10.35015093
107PRKACA0.34647492
108WNK10.34190291
109MKNK20.34112090
110PRKG10.33998966
111FGFR20.33360281
112TRIB30.33209640
113NEK90.32627111
114ROCK20.32312586
115CSNK1D0.32251607
116CAMKK10.31558730
117PRKCZ0.31409448
118ERBB20.30567058
119BRAF0.29812697
120PAK60.28930659
121IGF1R0.28622380
122PRKD20.27997491
123CAMK40.27865339
124MAPK40.27432418
125CDK180.27374160
126RPS6KA30.26249773
127CDK150.25807289
128PRKCA0.25453585
129CSNK1A10.24406958
130PRKCQ0.23735077
131EPHA30.23569316
132PAK30.23422075
133UHMK10.23263914
134RPS6KB10.22463761
135SRC0.21968014
136BMX0.21440223
137PRKACG0.21434125
138GSK3B0.21318676
139MAPK100.19198269

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.24657746
2Nicotine addiction_Homo sapiens_hsa050333.45689245
3Nitrogen metabolism_Homo sapiens_hsa009103.40544086
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44150355
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37731217
6Glutamatergic synapse_Homo sapiens_hsa047242.32336634
7Fatty acid metabolism_Homo sapiens_hsa012122.26582674
8GABAergic synapse_Homo sapiens_hsa047272.24558507
9Steroid biosynthesis_Homo sapiens_hsa001002.19291176
10Circadian entrainment_Homo sapiens_hsa047131.95295621
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86168314
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84521754
13Morphine addiction_Homo sapiens_hsa050321.78651615
14Fatty acid degradation_Homo sapiens_hsa000711.65588737
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64821294
16Salivary secretion_Homo sapiens_hsa049701.63760772
17Basal cell carcinoma_Homo sapiens_hsa052171.61251886
18Axon guidance_Homo sapiens_hsa043601.59207672
19Cocaine addiction_Homo sapiens_hsa050301.56862341
20Insulin secretion_Homo sapiens_hsa049111.51221089
21Circadian rhythm_Homo sapiens_hsa047101.50804695
22Estrogen signaling pathway_Homo sapiens_hsa049151.47652529
23Olfactory transduction_Homo sapiens_hsa047401.44228979
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42495422
25Synaptic vesicle cycle_Homo sapiens_hsa047211.41479175
26Calcium signaling pathway_Homo sapiens_hsa040201.35503524
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31928490
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31756784
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30003614
30Sulfur metabolism_Homo sapiens_hsa009201.26846743
31Taste transduction_Homo sapiens_hsa047421.24111029
32Serotonergic synapse_Homo sapiens_hsa047261.21691752
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20642601
34PPAR signaling pathway_Homo sapiens_hsa033201.19930451
35Amphetamine addiction_Homo sapiens_hsa050311.19375901
36Hedgehog signaling pathway_Homo sapiens_hsa043401.18502398
37beta-Alanine metabolism_Homo sapiens_hsa004101.17931138
38Gastric acid secretion_Homo sapiens_hsa049711.16955429
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10553936
40Melanogenesis_Homo sapiens_hsa049161.09623658
41Cholinergic synapse_Homo sapiens_hsa047251.06513347
42Renin secretion_Homo sapiens_hsa049241.05122689
43Mineral absorption_Homo sapiens_hsa049781.04693962
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03766294
45Long-term potentiation_Homo sapiens_hsa047201.03017214
46Propanoate metabolism_Homo sapiens_hsa006401.02813265
47Notch signaling pathway_Homo sapiens_hsa043301.01241914
48Histidine metabolism_Homo sapiens_hsa003401.00946406
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99174659
50cAMP signaling pathway_Homo sapiens_hsa040240.98710902
51Fatty acid elongation_Homo sapiens_hsa000620.98410378
52Prion diseases_Homo sapiens_hsa050200.98406776
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97853966
54Wnt signaling pathway_Homo sapiens_hsa043100.96656171
55Dopaminergic synapse_Homo sapiens_hsa047280.95293825
56Ether lipid metabolism_Homo sapiens_hsa005650.94941362
57Sulfur relay system_Homo sapiens_hsa041220.94479075
58Long-term depression_Homo sapiens_hsa047300.91533692
59Dorso-ventral axis formation_Homo sapiens_hsa043200.86307840
60African trypanosomiasis_Homo sapiens_hsa051430.85126470
61Ribosome_Homo sapiens_hsa030100.84587267
62Glioma_Homo sapiens_hsa052140.83108538
63Dilated cardiomyopathy_Homo sapiens_hsa054140.79884122
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.79746231
65Gap junction_Homo sapiens_hsa045400.79586604
66Butanoate metabolism_Homo sapiens_hsa006500.75695867
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73463907
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69922508
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68610566
70Oxytocin signaling pathway_Homo sapiens_hsa049210.65174197
71Arginine and proline metabolism_Homo sapiens_hsa003300.61855050
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61211195
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.60234789
74Peroxisome_Homo sapiens_hsa041460.59426072
75Cardiac muscle contraction_Homo sapiens_hsa042600.58499099
76Rap1 signaling pathway_Homo sapiens_hsa040150.57633565
77Type I diabetes mellitus_Homo sapiens_hsa049400.57138270
78Bile secretion_Homo sapiens_hsa049760.56400335
79Melanoma_Homo sapiens_hsa052180.55693526
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55169347
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54151988
82Vitamin digestion and absorption_Homo sapiens_hsa049770.53873244
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52178793
84Vitamin B6 metabolism_Homo sapiens_hsa007500.52136949
85Hippo signaling pathway_Homo sapiens_hsa043900.51902285
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51521385
87Alzheimers disease_Homo sapiens_hsa050100.51097516
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50280684
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50143000
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49911300
91Pancreatic secretion_Homo sapiens_hsa049720.49742270
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.48777647
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48666543
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48587101
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48171395
96Glycerolipid metabolism_Homo sapiens_hsa005610.47989194
97Tight junction_Homo sapiens_hsa045300.47944450
98Ras signaling pathway_Homo sapiens_hsa040140.47480347
99ErbB signaling pathway_Homo sapiens_hsa040120.47220430
100Phototransduction_Homo sapiens_hsa047440.46890017
101Sphingolipid metabolism_Homo sapiens_hsa006000.46395547
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46338889
103Parkinsons disease_Homo sapiens_hsa050120.45837041
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.45321262
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45162969
106Oxidative phosphorylation_Homo sapiens_hsa001900.44525714
107Glucagon signaling pathway_Homo sapiens_hsa049220.44298586
108Fructose and mannose metabolism_Homo sapiens_hsa000510.43051836
109Thyroid hormone synthesis_Homo sapiens_hsa049180.41950891
110Ovarian steroidogenesis_Homo sapiens_hsa049130.41236873
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41227938
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.40601749
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40591031
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40590947
115Choline metabolism in cancer_Homo sapiens_hsa052310.38987353
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38218403
117Linoleic acid metabolism_Homo sapiens_hsa005910.37990532
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37303704
119Alcoholism_Homo sapiens_hsa050340.36278170
120GnRH signaling pathway_Homo sapiens_hsa049120.35772945
121MAPK signaling pathway_Homo sapiens_hsa040100.34860767
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34701041

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