FAM71C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.77854001
2response to pheromone (GO:0019236)9.70816706
3DNA packaging (GO:0006323)9.32878091
4sperm capacitation (GO:0048240)9.16146039
5plasma membrane fusion (GO:0045026)8.71280847
6microtubule depolymerization (GO:0007019)8.53211389
7single strand break repair (GO:0000012)8.39756912
8spermatid nucleus differentiation (GO:0007289)8.20942991
9spermatid development (GO:0007286)8.08707314
10sperm-egg recognition (GO:0035036)7.66405891
11binding of sperm to zona pellucida (GO:0007339)7.16920991
12multicellular organism reproduction (GO:0032504)7.10804679
13sexual reproduction (GO:0019953)7.00761362
14rRNA methylation (GO:0031167)6.94625670
15microtubule polymerization or depolymerization (GO:0031109)6.93911534
16negative regulation of inclusion body assembly (GO:0090084)6.84554592
17reproduction (GO:0000003)6.83321429
18protein polyglutamylation (GO:0018095)6.74922655
19calcium ion-dependent exocytosis (GO:0017156)6.73241649
20protein targeting to Golgi (GO:0000042)6.52353567
21cell-cell recognition (GO:0009988)6.30101979
22establishment of protein localization to Golgi (GO:0072600)6.26427740
23spermatogenesis (GO:0007283)6.17720925
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.16826432
25male gamete generation (GO:0048232)6.15601523
26retrograde transport, vesicle recycling within Golgi (GO:0000301)6.06115467
27axonemal dynein complex assembly (GO:0070286)6.04229447
28cellular ketone body metabolic process (GO:0046950)5.88563226
29rRNA modification (GO:0000154)5.83325734
30microtubule severing (GO:0051013)5.79160221
31phosphatidylethanolamine metabolic process (GO:0046337)5.71473445
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.70316109
33gamete generation (GO:0007276)5.62829403
34centriole replication (GO:0007099)5.25616175
35ketone body metabolic process (GO:1902224)5.19511698
36regulation of Rab GTPase activity (GO:0032313)5.12396105
37positive regulation of Rab GTPase activity (GO:0032851)5.12396105
38single fertilization (GO:0007338)4.96357828
39regulation of cilium movement (GO:0003352)4.91911055
40regulation of inclusion body assembly (GO:0090083)4.91647169
41motile cilium assembly (GO:0044458)4.90556302
42chromatin silencing (GO:0006342)4.82613248
43centriole assembly (GO:0098534)4.66396256
44protein localization to Golgi apparatus (GO:0034067)4.65598448
45germ cell development (GO:0007281)4.56205312
46RNA destabilization (GO:0050779)4.53116116
47multicellular organismal reproductive process (GO:0048609)4.50600787
48cell wall macromolecule catabolic process (GO:0016998)4.47736659
49regulation of transcription involved in cell fate commitment (GO:0060850)4.41779150
50regulation of centriole replication (GO:0046599)4.38787209
51cilium or flagellum-dependent cell motility (GO:0001539)4.35108712
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.34946042
53coenzyme catabolic process (GO:0009109)4.21933963
54cell wall macromolecule metabolic process (GO:0044036)4.18651779
55nucleus organization (GO:0006997)4.12128447
56seminiferous tubule development (GO:0072520)4.08589396
57fertilization (GO:0009566)4.07197724
58glycerol ether metabolic process (GO:0006662)3.96289245
59negative regulation of Rho protein signal transduction (GO:0035024)3.92984566
60epithelial cilium movement (GO:0003351)3.77731565
61glomerular visceral epithelial cell development (GO:0072015)3.66882406
62multicellular organismal movement (GO:0050879)3.66238150
63musculoskeletal movement (GO:0050881)3.66238150
64ether metabolic process (GO:0018904)3.65746890
65glomerular epithelial cell development (GO:0072310)3.53017954
66organic cation transport (GO:0015695)3.44355121
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39050952
68regulation of microtubule-based movement (GO:0060632)3.35175325
69cilium movement (GO:0003341)3.33855409
70polyamine biosynthetic process (GO:0006596)3.30572015
71nucleosome disassembly (GO:0006337)3.29204308
72protein-DNA complex disassembly (GO:0032986)3.29204308
73negative regulation of gene expression, epigenetic (GO:0045814)3.29191165
74peptidyl-threonine dephosphorylation (GO:0035970)3.26249209
75response to acidic pH (GO:0010447)3.23948550
76mesenchymal cell differentiation involved in kidney development (GO:0072161)3.22278966
77mesenchymal cell differentiation involved in renal system development (GO:2001012)3.22278966
78protein depolymerization (GO:0051261)3.21308823
79histone H3-K9 demethylation (GO:0033169)3.19184199
80regulation of interleukin-13 production (GO:0032656)3.18147478
81membrane protein intracellular domain proteolysis (GO:0031293)3.16649530
82regulation of somitogenesis (GO:0014807)3.15370185
83cerebral cortex neuron differentiation (GO:0021895)3.14926686
84cell differentiation involved in metanephros development (GO:0072202)3.13754714
85cellular response to pH (GO:0071467)3.11762043
86cell recognition (GO:0008037)3.05094627
87cranial nerve morphogenesis (GO:0021602)3.04975889
88regulation of T-helper 2 cell differentiation (GO:0045628)3.03707399
89homeostasis of number of cells within a tissue (GO:0048873)3.01864144
90NAD biosynthetic process (GO:0009435)3.01101941
91multicellular organismal development (GO:0007275)3.00450896
92microtubule nucleation (GO:0007020)3.00256784
93DNA conformation change (GO:0071103)2.95119712
94regulation of phosphoprotein phosphatase activity (GO:0043666)2.79151887
95negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76626029
96tooth mineralization (GO:0034505)2.68935897
97negative regulation of histone methylation (GO:0031061)2.68584929
98acrosome reaction (GO:0007340)12.4438084
99sperm motility (GO:0030317)11.6294355
100fusion of sperm to egg plasma membrane (GO:0007342)11.4824835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.38447370
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06049704
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.74894758
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43459297
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43459297
6IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21900066
7CBP_20019798_ChIP-Seq_JUKART_Human2.21900066
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19962714
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.07000917
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05059383
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.00368999
12ERA_21632823_ChIP-Seq_H3396_Human1.99909017
13RAC3_21632823_ChIP-Seq_H3396_Human1.92199933
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91965036
15EZH2_22144423_ChIP-Seq_EOC_Human1.88208694
16DROSHA_22980978_ChIP-Seq_HELA_Human1.87581886
17EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.86786018
18NANOG_20526341_ChIP-Seq_ESCs_Human1.84439565
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79456485
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.78942901
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.76632524
22CTCF_27219007_Chip-Seq_Bcells_Human1.73987081
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69207783
24TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64313649
25* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63940227
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63420372
27TAF2_19829295_ChIP-Seq_ESCs_Human1.61898742
28BCL6_27268052_Chip-Seq_Bcells_Human1.61567321
29E2F1_20622854_ChIP-Seq_HELA_Human1.60554231
30MYC_19829295_ChIP-Seq_ESCs_Human1.60145666
31ER_23166858_ChIP-Seq_MCF-7_Human1.59071044
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.57897664
33SMC4_20622854_ChIP-Seq_HELA_Human1.53882200
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.53783888
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.51574882
36* FUS_26573619_Chip-Seq_HEK293_Human1.51522893
37BCOR_27268052_Chip-Seq_Bcells_Human1.50768099
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50506695
39CTCF_20526341_ChIP-Seq_ESCs_Human1.49341705
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49007949
41TP53_18474530_ChIP-ChIP_U2OS_Human1.47287045
42PHF8_20622854_ChIP-Seq_HELA_Human1.46589090
43TP63_22573176_ChIP-Seq_HFKS_Human1.46523014
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46440408
45P68_20966046_ChIP-Seq_HELA_Human1.45992116
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44308308
47OCT4_20526341_ChIP-Seq_ESCs_Human1.43873237
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41823624
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.38394783
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36560943
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34168779
52LXR_22292898_ChIP-Seq_THP-1_Human1.33883650
53TAF15_26573619_Chip-Seq_HEK293_Human1.33242616
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33118142
55RBPJ_21746931_ChIP-Seq_IB4_Human1.32964480
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32731959
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31866000
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.31722670
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.30509446
60P300_27268052_Chip-Seq_Bcells_Human1.30492697
61* AR_25329375_ChIP-Seq_VCAP_Human1.30054327
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29909089
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.27615869
64ETV1_20927104_ChIP-Seq_GIST48_Human1.27301889
65ERG_20517297_ChIP-Seq_VCAP_Human1.26251971
66P300_19829295_ChIP-Seq_ESCs_Human1.26106048
67RUNX_20019798_ChIP-Seq_JUKART_Human1.25291090
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22970681
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22692165
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21351229
71CEBPB_22108803_ChIP-Seq_LS180_Human1.20916049
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20570809
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.19687066
74P53_21459846_ChIP-Seq_SAOS-2_Human1.19031831
75TBL1_22424771_ChIP-Seq_293T_Human1.17934366
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16052951
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15028044
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.13346726
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13178994
80SA1_27219007_Chip-Seq_Bcells_Human1.11055517
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10510501
82PHF8_20622853_ChIP-Seq_HELA_Human1.10129275
83* NFYB_21822215_ChIP-Seq_K562_Human1.09025373
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08944309
85SMRT_27268052_Chip-Seq_Bcells_Human1.08271210
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.08168591
87RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06748451
88* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06433038
89HOXB7_26014856_ChIP-Seq_BT474_Human1.03452828
90NANOG_19829295_ChIP-Seq_ESCs_Human1.03420114
91SOX2_19829295_ChIP-Seq_ESCs_Human1.03420114
92ZNF274_21170338_ChIP-Seq_K562_Hela1.02950074
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00739076
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.00169882
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99879871
96NFYA_21822215_ChIP-Seq_K562_Human0.99504682
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97263363
98SMAD4_21799915_ChIP-Seq_A2780_Human0.96403205
99CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95261737
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95072237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.00579072
2MP0003878_abnormal_ear_physiology5.00579072
3MP0005670_abnormal_white_adipose4.47291480
4MP0003698_abnormal_male_reproductive4.44804629
5MP0001929_abnormal_gametogenesis3.82245433
6MP0001348_abnormal_lacrimal_gland3.62738719
7MP0000678_abnormal_parathyroid_gland2.69715807
8MP0002161_abnormal_fertility/fecundity2.49087571
9MP0003011_delayed_dark_adaptation2.46852779
10MP0003718_maternal_effect2.22135900
11MP0003646_muscle_fatigue2.05258105
12MP0002132_abnormal_respiratory_system2.00804075
13MP0005410_abnormal_fertilization12.4535651
14MP0005423_abnormal_somatic_nervous1.85298269
15MP0002234_abnormal_pharynx_morphology1.76023824
16MP0005379_endocrine/exocrine_gland_phen1.75966592
17MP0002210_abnormal_sex_determination1.62697456
18MP0002249_abnormal_larynx_morphology1.60669075
19MP0004510_myositis1.60609789
20MP0001486_abnormal_startle_reflex1.54317700
21MP0009053_abnormal_anal_canal1.46807961
22MP0001485_abnormal_pinna_reflex1.43731150
23MP0002282_abnormal_trachea_morphology1.43607967
24MP0005310_abnormal_salivary_gland1.41100971
25MP0001145_abnormal_male_reproductive1.35119474
26MP0004742_abnormal_vestibular_system1.29673587
27MP0000653_abnormal_sex_gland1.29463242
28MP0001765_abnormal_ion_homeostasis1.28476531
29MP0002735_abnormal_chemical_nociception1.25565894
30MP0004859_abnormal_synaptic_plasticity1.25484949
31MP0001968_abnormal_touch/_nociception1.24887114
32MP0000534_abnormal_ureter_morphology1.20597782
33MP0002138_abnormal_hepatobiliary_system1.19929782
34MP0002127_abnormal_cardiovascular_syste1.18065964
35MP0005248_abnormal_Harderian_gland1.09547582
36MP0001963_abnormal_hearing_physiology1.09276859
37MP0003879_abnormal_hair_cell1.07243398
38MP0005395_other_phenotype1.05127327
39MP0000026_abnormal_inner_ear0.97078800
40MP0002822_catalepsy0.94988946
41MP0002229_neurodegeneration0.88153903
42MP0000955_abnormal_spinal_cord0.86918623
43MP0000681_abnormal_thyroid_gland0.86343475
44MP0005451_abnormal_body_composition0.82807324
45MP0002733_abnormal_thermal_nociception0.80601315
46MP0000049_abnormal_middle_ear0.79155572
47MP0008877_abnormal_DNA_methylation0.76817361
48MP0005551_abnormal_eye_electrophysiolog0.76537072
49MP0002653_abnormal_ependyma_morphology0.76103025
50MP0004085_abnormal_heartbeat0.76004480
51MP0002067_abnormal_sensory_capabilities0.74227357
52MP0000516_abnormal_urinary_system0.73389251
53MP0005367_renal/urinary_system_phenotyp0.73389251
54MP0005636_abnormal_mineral_homeostasis0.73059497
55MP0008569_lethality_at_weaning0.71025305
56MP0009115_abnormal_fat_cell0.69595712
57MP0005083_abnormal_biliary_tract0.68891553
58MP0005666_abnormal_adipose_tissue0.68133326
59MP0001879_abnormal_lymphatic_vessel0.67346041
60MP0002557_abnormal_social/conspecific_i0.66730876
61MP0003880_abnormal_central_pattern0.65805257
62MP0005253_abnormal_eye_physiology0.60565989
63MP0005167_abnormal_blood-brain_barrier0.59953310
64MP0004484_altered_response_of0.59643259
65MP0001666_abnormal_nutrient_absorption0.57952212
66MP0005375_adipose_tissue_phenotype0.57897167
67MP0002572_abnormal_emotion/affect_behav0.56675057
68MP0001970_abnormal_pain_threshold0.56614636
69MP0008995_early_reproductive_senescence0.53259810
70MP0001984_abnormal_olfaction0.52835916
71MP0002272_abnormal_nervous_system0.52652901
72MP0001905_abnormal_dopamine_level0.52169861
73MP0001501_abnormal_sleep_pattern0.50807475
74MP0003137_abnormal_impulse_conducting0.50619201
75MP0002734_abnormal_mechanical_nocicepti0.50400982
76MP0003077_abnormal_cell_cycle0.48295873
77MP0005623_abnormal_meninges_morphology0.47821839
78MP0009697_abnormal_copulation0.47352758
79MP0004036_abnormal_muscle_relaxation0.47350439
80MP0004233_abnormal_muscle_weight0.47138887
81MP0003119_abnormal_digestive_system0.46773976
82MP0001440_abnormal_grooming_behavior0.46175828
83MP0008961_abnormal_basal_metabolism0.45351290
84MP0000003_abnormal_adipose_tissue0.44930853
85MP0005535_abnormal_body_temperature0.44104715
86MP0009745_abnormal_behavioral_response0.43472669
87MP0003699_abnormal_female_reproductive0.41370581
88MP0000470_abnormal_stomach_morphology0.40731109
89MP0000249_abnormal_blood_vessel0.40177384
90MP0000613_abnormal_salivary_gland0.39726836
91MP0005408_hypopigmentation0.39335272
92MP0006292_abnormal_olfactory_placode0.39252324
93MP0003172_abnormal_lysosome_physiology0.37840321
94MP0003635_abnormal_synaptic_transmissio0.36973158
95MP0000230_abnormal_systemic_arterial0.35248044
96MP0003936_abnormal_reproductive_system0.34665046
97MP0000566_synostosis0.34333169
98MP0002928_abnormal_bile_duct0.33137926
99MP0002882_abnormal_neuron_morphology0.31707252
100MP0003631_nervous_system_phenotype0.30375537

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.62385717
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.89999668
3Absent/shortened dynein arms (HP:0200106)5.89999668
4Asymmetric septal hypertrophy (HP:0001670)5.36472805
5Attenuation of retinal blood vessels (HP:0007843)5.28938028
6Bony spicule pigmentary retinopathy (HP:0007737)5.25066339
7Resting tremor (HP:0002322)4.59988059
8Tubulointerstitial nephritis (HP:0001970)4.59003163
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.54733771
10Abnormal ciliary motility (HP:0012262)4.48348184
11Abnormal respiratory motile cilium physiology (HP:0012261)4.39385219
12Chronic hepatic failure (HP:0100626)4.32091974
13Bell-shaped thorax (HP:0001591)4.30000140
14Hyperkalemia (HP:0002153)4.23434318
15Abnormal rod and cone electroretinograms (HP:0008323)4.22981322
16Abnormal respiratory motile cilium morphology (HP:0005938)4.19873724
17Abnormal respiratory epithelium morphology (HP:0012253)4.19873724
18Nasal polyposis (HP:0100582)4.18524859
19Hypoplastic ischia (HP:0003175)4.18004259
20Infertility (HP:0000789)4.09711884
21Male infertility (HP:0003251)4.04744461
22Abnormality of macular pigmentation (HP:0008002)3.99634189
23Facial shape deformation (HP:0011334)3.90991945
24Potter facies (HP:0002009)3.90991945
25Enlarged epiphyses (HP:0010580)3.79611954
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.72119099
27Abnormality of the ischium (HP:0003174)3.71726884
28Azoospermia (HP:0000027)3.71324655
29Cone-rod dystrophy (HP:0000548)3.58043952
30Abnormal spermatogenesis (HP:0008669)3.57000478
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.56485945
32Abnormality of the nasal mucosa (HP:0000433)3.40588740
33Unilateral renal agenesis (HP:0000122)3.36137158
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.32416569
35Hypoplasia of the thymus (HP:0000778)3.09469779
36Impulsivity (HP:0100710)3.09182208
37Congenital malformation of the right heart (HP:0011723)2.96369077
38Double outlet right ventricle (HP:0001719)2.96369077
39Progressive sensorineural hearing impairment (HP:0000408)2.94704498
40Postural instability (HP:0002172)2.87340969
41Abnormality of the aortic arch (HP:0012303)2.84794409
42Abnormal urine output (HP:0012590)2.79728472
43Generalized aminoaciduria (HP:0002909)2.75572980
44Hypoalphalipoproteinemia (HP:0003233)2.74605657
45Stage 5 chronic kidney disease (HP:0003774)2.72032225
46Renal dysplasia (HP:0000110)2.70840397
47Amelogenesis imperfecta (HP:0000705)2.62382178
48Nephronophthisis (HP:0000090)2.61933640
49Progressive cerebellar ataxia (HP:0002073)2.57503704
50Rhinitis (HP:0012384)2.56345854
51Abnormality of potassium homeostasis (HP:0011042)2.52038886
52Truncal obesity (HP:0001956)2.48447108
53Abnormality of the costochondral junction (HP:0000919)2.44164813
54Abnormality of dental color (HP:0011073)2.43228301
55Abnormality of renal excretion (HP:0011036)2.39924504
56Abnormality of the parathyroid morphology (HP:0011766)2.37496104
57Polydipsia (HP:0001959)2.37135831
58Abnormal drinking behavior (HP:0030082)2.37135831
59Portal hypertension (HP:0001409)2.34225179
60Flattened epiphyses (HP:0003071)2.32085369
61Epiphyseal dysplasia (HP:0002656)2.31075220
62Ventricular tachycardia (HP:0004756)2.29859123
63Insulin-resistant diabetes mellitus (HP:0000831)2.28578450
64Polyuria (HP:0000103)2.23185716
65Renovascular hypertension (HP:0100817)2.20824591
66Abnormality of the renal medulla (HP:0100957)2.20348267
67Menstrual irregularities (HP:0000858)2.20040562
68Hyponatremia (HP:0002902)2.18540145
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16099277
70Absent epiphyses (HP:0010577)2.16099277
71Tubulointerstitial abnormality (HP:0001969)2.15744754
72Abnormality of the hepatic vasculature (HP:0006707)2.13511510
73Osteomalacia (HP:0002749)2.09439952
74Abnormality of the epiphysis of the femoral head (HP:0010574)2.08420067
75Abnormality of the pubic bones (HP:0003172)2.07492962
76Tetany (HP:0001281)2.04905375
77Bronchiectasis (HP:0002110)2.02470198
78Focal segmental glomerulosclerosis (HP:0000097)2.02142583
79Chronic bronchitis (HP:0004469)1.99952737
80Decreased central vision (HP:0007663)1.96602466
81Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94641185
82Abnormality of femoral epiphyses (HP:0006499)1.94641185
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91523546
84Optic nerve hypoplasia (HP:0000609)1.90996967
85Widely patent fontanelles and sutures (HP:0004492)1.90149258
86Fatigable weakness (HP:0003473)1.86110240
87Abnormality of the neuromuscular junction (HP:0003398)1.86110240
88Abnormality of the femoral head (HP:0003368)1.85407289
89Hyperthyroidism (HP:0000836)1.85375397
90Hypophosphatemic rickets (HP:0004912)1.84893657
91Progressive hearing impairment (HP:0001730)1.83598258
92Recurrent pneumonia (HP:0006532)1.81704400
93Abnormal ventriculo-arterial connection (HP:0011563)1.81315334
94Transposition of the great arteries (HP:0001669)1.81315334
95Abnormal connection of the cardiac segments (HP:0011545)1.81315334
96Recurrent corneal erosions (HP:0000495)1.81070456
97Flat capital femoral epiphysis (HP:0003370)1.81063834
98Bradycardia (HP:0001662)1.81017545
99Renal Fanconi syndrome (HP:0001994)1.80751884
100Spastic paraparesis (HP:0002313)1.79951532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.37022809
2TESK16.21949250
3DDR25.11255480
4INSRR4.31862381
5MAP4K23.86561929
6BRD43.13823387
7PLK23.09685830
8STK383.04788561
9PNCK2.63752024
10PRKD32.28927587
11MAPK152.25574168
12STK38L2.19446903
13CAMK1G2.16432569
14WNK11.83344631
15PIK3CG1.75240419
16MST1R1.61696870
17PDPK11.57842100
18PDK11.51440354
19CDK121.31428695
20DYRK1B1.30962601
21MUSK1.27455909
22CDK71.25639008
23PTK2B1.20455169
24NEK61.14036429
25MAP3K91.12789300
26KSR21.11010491
27LATS20.84466029
28CAMK1D0.84434776
29AKT30.81260969
30UHMK10.78051757
31PRKG20.73354267
32LATS10.71412240
33PRKAA20.70269532
34RPS6KA20.69589990
35BRAF0.69481737
36TYRO30.69025725
37MAP3K110.67236342
38MAP3K20.63259432
39PRKG10.62709261
40MAP2K20.62194028
41SIK20.57395776
42RPS6KA10.57197472
43CAMK10.55948403
44ROCK10.54892849
45WNK40.53452631
46MAP3K80.53313817
47MARK10.47778552
48STK390.45576572
49CDK30.45038293
50CDK40.44598102
51GSK3B0.44068937
52CDK20.40332981
53PRKCG0.39585651
54MAPK10.39422125
55CAMK40.39304276
56CDK10.38157975
57ARAF0.36664553
58SGK4940.34245620
59SGK2230.34245620
60MAPK80.33561318
61RPS6KC10.33389816
62RPS6KL10.33389816
63BMPR1B0.33174372
64PRKCZ0.32607645
65TIE10.32509868
66MAP3K10.31508313
67RPS6KA60.31186046
68MTOR0.30920721
69NTRK30.30589151
70MAP3K40.29807676
71CHEK10.25906111
72MAPK100.23984273
73TESK20.23371140
74PRKCB0.22622193
75MARK20.22018603
76SGK10.22011131
77MAPK140.20860842
78FER0.20414260
79FRK0.20399929
80MET0.17282562
81PKN10.16125773
82AKT10.15785720
83OXSR10.14431749
84BRSK10.14075750
85BLK0.14012407
86MAP3K70.12149794
87MAPK110.10984384
88DYRK30.09982508
89PRKACA0.09792769
90MAPK90.09354945
91RIPK40.08898411
92PRKACB0.08426142
93CAMK2A0.07603002
94IKBKB0.07284049
95PRKAA10.06394145
96PINK10.05080837
97CHUK0.04599026
98RPS6KA30.04523904
99ZAK0.04327228
100ADRBK20.04217610

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.26649914
2Fatty acid biosynthesis_Homo sapiens_hsa000615.83524852
3Olfactory transduction_Homo sapiens_hsa047403.72845769
4Butanoate metabolism_Homo sapiens_hsa006502.83244574
5Allograft rejection_Homo sapiens_hsa053302.01803767
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.01552333
7Type I diabetes mellitus_Homo sapiens_hsa049401.99556283
8Autoimmune thyroid disease_Homo sapiens_hsa053201.97028567
9Taste transduction_Homo sapiens_hsa047421.85912152
10Graft-versus-host disease_Homo sapiens_hsa053321.84945230
11Antigen processing and presentation_Homo sapiens_hsa046121.76166546
12Dorso-ventral axis formation_Homo sapiens_hsa043201.75761210
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66259779
14Phenylalanine metabolism_Homo sapiens_hsa003601.58218505
15Type II diabetes mellitus_Homo sapiens_hsa049301.56818410
16Fatty acid degradation_Homo sapiens_hsa000711.52682241
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50343040
18Viral myocarditis_Homo sapiens_hsa054161.39332355
19Fatty acid metabolism_Homo sapiens_hsa012121.35621987
20RNA transport_Homo sapiens_hsa030131.33859683
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30880383
22Arginine and proline metabolism_Homo sapiens_hsa003301.28491444
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25228248
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18879865
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12783755
26Endocytosis_Homo sapiens_hsa041441.11269007
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.06286054
28Salivary secretion_Homo sapiens_hsa049701.05581784
29Phototransduction_Homo sapiens_hsa047441.05158793
30Protein digestion and absorption_Homo sapiens_hsa049741.04347666
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00006551
32Cardiac muscle contraction_Homo sapiens_hsa042600.96033335
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95576524
34Arginine biosynthesis_Homo sapiens_hsa002200.90856157
35Morphine addiction_Homo sapiens_hsa050320.88163327
36cAMP signaling pathway_Homo sapiens_hsa040240.87227636
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84325772
38Inositol phosphate metabolism_Homo sapiens_hsa005620.83001503
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81859320
40Calcium signaling pathway_Homo sapiens_hsa040200.81300271
41Influenza A_Homo sapiens_hsa051640.80814819
42Oocyte meiosis_Homo sapiens_hsa041140.80532249
43PPAR signaling pathway_Homo sapiens_hsa033200.80010745
44Fat digestion and absorption_Homo sapiens_hsa049750.75329400
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73758161
46Nicotine addiction_Homo sapiens_hsa050330.73300424
47Renin-angiotensin system_Homo sapiens_hsa046140.71013976
48Synaptic vesicle cycle_Homo sapiens_hsa047210.70243661
49Hedgehog signaling pathway_Homo sapiens_hsa043400.69366446
50Circadian entrainment_Homo sapiens_hsa047130.69158768
51Estrogen signaling pathway_Homo sapiens_hsa049150.67995892
52ABC transporters_Homo sapiens_hsa020100.67578003
53Tyrosine metabolism_Homo sapiens_hsa003500.66524853
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63863335
55Glutamatergic synapse_Homo sapiens_hsa047240.61674720
56Retinol metabolism_Homo sapiens_hsa008300.60312160
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.59625995
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59511878
59Glycerolipid metabolism_Homo sapiens_hsa005610.58366894
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58205239
61Basal transcription factors_Homo sapiens_hsa030220.55478957
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54764255
63Renin secretion_Homo sapiens_hsa049240.52857566
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52603434
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.49928262
66Insulin secretion_Homo sapiens_hsa049110.49045394
67VEGF signaling pathway_Homo sapiens_hsa043700.47963369
68MAPK signaling pathway_Homo sapiens_hsa040100.46844178
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45895026
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.44947835
71Bile secretion_Homo sapiens_hsa049760.44767536
72Gastric acid secretion_Homo sapiens_hsa049710.44064323
73Purine metabolism_Homo sapiens_hsa002300.42837974
74Selenocompound metabolism_Homo sapiens_hsa004500.41448335
75Serotonergic synapse_Homo sapiens_hsa047260.39439065
76Tight junction_Homo sapiens_hsa045300.37695532
77Acute myeloid leukemia_Homo sapiens_hsa052210.34878849
78Cholinergic synapse_Homo sapiens_hsa047250.34576270
79Pancreatic secretion_Homo sapiens_hsa049720.32934936
80mRNA surveillance pathway_Homo sapiens_hsa030150.32915058
81Nitrogen metabolism_Homo sapiens_hsa009100.32833895
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.32472410
83Vitamin B6 metabolism_Homo sapiens_hsa007500.30587933
84Viral carcinogenesis_Homo sapiens_hsa052030.30238492
85Herpes simplex infection_Homo sapiens_hsa051680.27869408
86GABAergic synapse_Homo sapiens_hsa047270.27722504
87Long-term potentiation_Homo sapiens_hsa047200.27648840
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26862176
89Oxytocin signaling pathway_Homo sapiens_hsa049210.24787814
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19802459
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17633186
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16728709
93ECM-receptor interaction_Homo sapiens_hsa045120.16475872
94Prolactin signaling pathway_Homo sapiens_hsa049170.16114076
95Huntingtons disease_Homo sapiens_hsa050160.15746922
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15530282
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15371033
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.15331690
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15076336
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15023641

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