FAM71D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.84281684
2spermatid development (GO:0007286)9.65397686
3motile cilium assembly (GO:0044458)9.35164959
4regulation of cilium movement (GO:0003352)8.95645134
5response to pheromone (GO:0019236)8.71169510
6cilium movement (GO:0003341)8.56098473
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.90790877
8single fertilization (GO:0007338)7.77663656
9sperm capacitation (GO:0048240)7.74236794
10piRNA metabolic process (GO:0034587)7.29446741
11male meiosis (GO:0007140)7.20788190
12synaptonemal complex organization (GO:0070193)7.03611444
13synaptonemal complex assembly (GO:0007130)6.86290705
14negative regulation of inclusion body assembly (GO:0090084)6.66113484
15protein targeting to Golgi (GO:0000042)6.54138746
16fertilization (GO:0009566)6.48799207
17establishment of protein localization to Golgi (GO:0072600)6.46835249
18microtubule depolymerization (GO:0007019)6.46410182
19spermatogenesis (GO:0007283)6.46228793
20male gamete generation (GO:0048232)6.43849789
21rRNA methylation (GO:0031167)6.27584643
22organic cation transport (GO:0015695)6.23325572
23retrograde transport, vesicle recycling within Golgi (GO:0000301)5.94768417
24gamete generation (GO:0007276)5.93102993
25centriole replication (GO:0007099)5.77201353
26regulation of inclusion body assembly (GO:0090083)5.60979895
27rRNA modification (GO:0000154)5.57565546
28calcium ion-dependent exocytosis (GO:0017156)5.48864704
29ventricular system development (GO:0021591)5.43127467
30germ cell development (GO:0007281)5.38229035
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.36205311
32regulation of microtubule-based movement (GO:0060632)5.31027139
33phosphatidylethanolamine biosynthetic process (GO:0006646)5.14827972
34cellular ketone body metabolic process (GO:0046950)5.13887458
35cell recognition (GO:0008037)5.06291059
36protein localization to Golgi apparatus (GO:0034067)5.01375060
37spermatid nucleus differentiation (GO:0007289)4.93295376
38microtubule severing (GO:0051013)4.86239303
39glycerol ether metabolic process (GO:0006662)4.80472700
40male meiosis I (GO:0007141)4.80103603
41phosphatidylethanolamine metabolic process (GO:0046337)4.76864673
42multicellular organismal reproductive process (GO:0048609)4.69276577
43chromosome organization involved in meiosis (GO:0070192)4.68506952
44DNA methylation involved in gamete generation (GO:0043046)4.62148736
45ketone body metabolic process (GO:1902224)4.52671315
46ether metabolic process (GO:0018904)4.44025101
47left/right pattern formation (GO:0060972)4.39817137
48regulation of Rab GTPase activity (GO:0032313)4.39320575
49positive regulation of Rab GTPase activity (GO:0032851)4.39320575
50seminiferous tubule development (GO:0072520)4.34535425
51meiotic nuclear division (GO:0007126)4.24101278
52chromosome condensation (GO:0030261)4.23075244
53regulation of transcription involved in cell fate commitment (GO:0060850)4.21608076
54DNA packaging (GO:0006323)4.01333642
55regulation of centriole replication (GO:0046599)3.99405174
56monoubiquitinated protein deubiquitination (GO:0035520)3.90665187
57chaperone-mediated protein complex assembly (GO:0051131)3.88915322
58single strand break repair (GO:0000012)3.85998854
59sexual reproduction (GO:0019953)3.85866405
60meiosis I (GO:0007127)3.84853491
61RNA destabilization (GO:0050779)3.84390907
62multicellular organismal development (GO:0007275)3.74697337
63genitalia morphogenesis (GO:0035112)3.72669562
64protein polyglutamylation (GO:0018095)3.72499069
65coenzyme catabolic process (GO:0009109)3.72474801
66protein K11-linked deubiquitination (GO:0035871)3.48999617
67microtubule polymerization or depolymerization (GO:0031109)3.38848962
68protein localization to cilium (GO:0061512)3.35509645
69meiotic cell cycle (GO:0051321)3.35039158
70chromatin silencing (GO:0006342)3.34170012
71protein refolding (GO:0042026)3.29783176
72glycolytic process (GO:0006096)3.24677617
73negative regulation of Rho protein signal transduction (GO:0035024)3.21435859
74microtubule nucleation (GO:0007020)3.21398730
75regulation of spindle checkpoint (GO:0090231)3.16312333
76polyol catabolic process (GO:0046174)3.15933184
77nucleoside diphosphate phosphorylation (GO:0006165)3.06133960
78alditol metabolic process (GO:0019400)3.04076656
79carnitine transport (GO:0015879)3.02823714
80amino-acid betaine transport (GO:0015838)3.02823714
81NAD biosynthetic process (GO:0009435)3.02536511
82nucleus organization (GO:0006997)2.96930395
83response to acidic pH (GO:0010447)2.96801158
84cilium organization (GO:0044782)2.95351674
85microtubule-based movement (GO:0007018)2.95322518
86spinal cord motor neuron differentiation (GO:0021522)2.89912263
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89708487
88musculoskeletal movement (GO:0050881)2.89052676
89multicellular organismal movement (GO:0050879)2.89052676
90lactate metabolic process (GO:0006089)2.89024839
91tooth mineralization (GO:0034505)2.88205937
92GTP biosynthetic process (GO:0006183)2.86334327
93carnitine transmembrane transport (GO:1902603)2.85935656
94intraciliary transport (GO:0042073)2.85591316
95mitotic sister chromatid cohesion (GO:0007064)2.84796874
96cilium assembly (GO:0042384)2.84794977
97alanine transport (GO:0032328)2.84399658
98mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82209584
99mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82209584
100cranial nerve morphogenesis (GO:0021602)2.81789731
101cilium morphogenesis (GO:0060271)2.80807129
102negative regulation of organelle assembly (GO:1902116)2.80316269
103sequestering of actin monomers (GO:0042989)2.79955930
104cellular response to pH (GO:0071467)2.77840178
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77301610
106cellular component assembly involved in morphogenesis (GO:0010927)2.77100749
107meiotic cell cycle process (GO:1903046)2.74953593
108cerebral cortex neuron differentiation (GO:0021895)2.74742197
109synapsis (GO:0007129)2.73494199
110behavioral response to nicotine (GO:0035095)2.70858737
111axoneme assembly (GO:0035082)2.70485553
112neurofilament cytoskeleton organization (GO:0060052)2.70409651
113gene silencing by RNA (GO:0031047)2.69668599
114RNA localization (GO:0006403)2.67818399
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.65404092
116microtubule bundle formation (GO:0001578)2.64097873
117cell differentiation involved in metanephros development (GO:0072202)2.64004065
118outer ear morphogenesis (GO:0042473)2.63831466
119positive regulation of action potential (GO:0045760)2.62075640
120peptidyl-glutamic acid modification (GO:0018200)2.59389402
121regulation of cilium assembly (GO:1902017)2.58018581
122centriole assembly (GO:0098534)2.57568501
123glycerol metabolic process (GO:0006071)2.56825910
124negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.56672805
125detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.54675101
126interferon-gamma secretion (GO:0072643)2.54603844
127UTP biosynthetic process (GO:0006228)2.54395133
128somite rostral/caudal axis specification (GO:0032525)2.53782818
129positive regulation of macrophage activation (GO:0043032)2.48900953
130polyamine biosynthetic process (GO:0006596)2.44641407
131negative regulation of skeletal muscle tissue development (GO:0048642)2.41440272
132sperm motility (GO:0030317)14.1248676
133fusion of sperm to egg plasma membrane (GO:0007342)13.9756281
134cell wall macromolecule metabolic process (GO:0044036)12.7039639
135cell wall macromolecule catabolic process (GO:0016998)12.7039639
136acrosome reaction (GO:0007340)11.7651503
137sperm-egg recognition (GO:0035036)11.6050709
138multicellular organism reproduction (GO:0032504)11.5525747
139acrosome assembly (GO:0001675)11.4483873
140plasma membrane fusion (GO:0045026)10.6689678
141binding of sperm to zona pellucida (GO:0007339)10.4912588
142epithelial cilium movement (GO:0003351)10.4556582
143cell-cell recognition (GO:0009988)10.3873367
144cilium or flagellum-dependent cell motility (GO:0001539)10.3360249
145axonemal dynein complex assembly (GO:0070286)10.2447365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.24806389
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.78601110
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.42236430
4EZH2_22144423_ChIP-Seq_EOC_Human4.21291798
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.41967364
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17066832
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.00972241
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81105626
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70307025
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53836703
11VDR_22108803_ChIP-Seq_LS180_Human2.52845633
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.17473076
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16284149
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.12227068
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09188752
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01324874
17ERA_21632823_ChIP-Seq_H3396_Human1.98964810
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97675414
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97430683
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93665390
21ZNF274_21170338_ChIP-Seq_K562_Hela1.92736798
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.91556553
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.89948179
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89253975
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.86268857
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84128184
27NANOG_20526341_ChIP-Seq_ESCs_Human1.82484833
28MYC_19829295_ChIP-Seq_ESCs_Human1.74520380
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.72653413
30STAT1_17558387_ChIP-Seq_HELA_Human1.72030627
31TAF2_19829295_ChIP-Seq_ESCs_Human1.71165941
32* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71026282
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69014917
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68793720
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67997804
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66228682
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.65341108
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63941045
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.63389794
40BCL6_27268052_Chip-Seq_Bcells_Human1.61623997
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.60133930
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59815316
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58322177
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.57707025
45CTCF_27219007_Chip-Seq_Bcells_Human1.57180977
46RAC3_21632823_ChIP-Seq_H3396_Human1.57033964
47KDM2B_26808549_Chip-Seq_REH_Human1.56367679
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56144683
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55551609
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.55040899
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53490789
52* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52321186
53* ER_23166858_ChIP-Seq_MCF-7_Human1.51295835
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50405102
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.49665346
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49620845
57CBP_20019798_ChIP-Seq_JUKART_Human1.49620845
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48437523
59* TAL1_26923725_Chip-Seq_HPCs_Mouse1.47509672
60AR_25329375_ChIP-Seq_VCAP_Human1.45587901
61E2F1_20622854_ChIP-Seq_HELA_Human1.44424462
62OCT4_20526341_ChIP-Seq_ESCs_Human1.43138976
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42163779
64CTCF_20526341_ChIP-Seq_ESCs_Human1.41891337
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41748539
66P300_19829295_ChIP-Seq_ESCs_Human1.40659222
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.39879866
68DROSHA_22980978_ChIP-Seq_HELA_Human1.38445170
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36995879
70PHF8_20622854_ChIP-Seq_HELA_Human1.36557334
71RBPJ_21746931_ChIP-Seq_IB4_Human1.35165287
72REST_21632747_ChIP-Seq_MESCs_Mouse1.35145759
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34954270
74* GATA3_21867929_ChIP-Seq_CD8_Mouse1.33852482
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32956111
76P68_20966046_ChIP-Seq_HELA_Human1.31848242
77TAF15_26573619_Chip-Seq_HEK293_Human1.31362618
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31008837
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30925362
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30513829
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30347355
82* SMAD3_21741376_ChIP-Seq_ESCs_Human1.27960371
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27056891
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.26381619
85P53_21459846_ChIP-Seq_SAOS-2_Human1.25973393
86ETV1_20927104_ChIP-Seq_GIST48_Human1.24289859
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24145153
88* GATA3_21867929_ChIP-Seq_TH1_Mouse1.23891463
89* FLI1_21867929_ChIP-Seq_TH2_Mouse1.22960039
90CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22599332
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21726500
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21474880
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.21323926
94BCOR_27268052_Chip-Seq_Bcells_Human1.20647755
95JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20564623
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20143345
97P300_27268052_Chip-Seq_Bcells_Human1.19537556
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19441958
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19441958
100* NCOR_22424771_ChIP-Seq_293T_Human1.18350397
101* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18130138
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.17538408
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.17177306
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17177306
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.17108843
106* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16832531
107PHF8_20622853_ChIP-Seq_HELA_Human1.16291573
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15472227
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.14699010
110* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12840897
111FOXH1_21741376_ChIP-Seq_EPCs_Human1.12574875
112NANOG_19829295_ChIP-Seq_ESCs_Human1.11487088
113SOX2_19829295_ChIP-Seq_ESCs_Human1.11487088
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11469232
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.11214402
116RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10304098
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10036280
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09160163
119RNF2_27304074_Chip-Seq_NSC_Mouse1.08947454
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08830478
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08608462
122* GF1_26923725_Chip-Seq_HPCs_Mouse1.08495335
123IRF1_19129219_ChIP-ChIP_H3396_Human1.08027888
124* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08011285
125* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07953998
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.07534974
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07362435
128GATA6_21074721_ChIP-Seq_CACO-2_Human1.07194674
129* FOXH1_21741376_ChIP-Seq_ESCs_Human1.07193897
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07107817
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06413107
132P53_22387025_ChIP-Seq_ESCs_Mouse1.06396808
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.06296699
134SA1_27219007_Chip-Seq_Bcells_Human1.06090960
135HOXB7_26014856_ChIP-Seq_BT474_Human1.05644968
136CEBPB_22108803_ChIP-Seq_LS180_Human1.05422926
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04589535
138SMRT_27268052_Chip-Seq_Bcells_Human1.04486245
139ERG_20517297_ChIP-Seq_VCAP_Human1.04156807
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.04002739
141SPI1_26923725_Chip-Seq_HPCs_Mouse1.03643061
142SMC4_20622854_ChIP-Seq_HELA_Human1.03489597
143CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03350788
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03156986
145TP63_22573176_ChIP-Seq_HFKS_Human1.01771332
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01028755
147PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00798825
148EZH2_27294783_Chip-Seq_NPCs_Mouse1.00753616
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00466042
150P300_18555785_Chip-Seq_ESCs_Mouse0.99340928
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98579285
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98507307
153KLF4_18555785_Chip-Seq_ESCs_Mouse0.97414008
154SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96946022
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95525815
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95253529
157FUS_26573619_Chip-Seq_HEK293_Human0.94205484
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.94179040
159NFYB_21822215_ChIP-Seq_K562_Human0.94100774
160SOX9_26525672_Chip-Seq_HEART_Mouse0.93975858
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93812769
162* ESET_19884257_ChIP-Seq_ESCs_Mouse0.93047510
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92447926
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91379183
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91110955
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.90329541
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90283746
168KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89712280
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.89281975
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89071235
171SMAD4_21741376_ChIP-Seq_EPCs_Human0.89069692
172TBL1_22424771_ChIP-Seq_293T_Human0.88716728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11745204
2MP0001929_abnormal_gametogenesis5.50199456
3MP0008877_abnormal_DNA_methylation4.16823205
4MP0002210_abnormal_sex_determination3.39620702
5MP0002161_abnormal_fertility/fecundity3.35711022
6MP0001348_abnormal_lacrimal_gland3.09551433
7MP0001145_abnormal_male_reproductive2.87313675
8MP0002653_abnormal_ependyma_morphology2.74002685
9MP0005670_abnormal_white_adipose2.72884374
10MP0000653_abnormal_sex_gland2.50587992
11MP0005379_endocrine/exocrine_gland_phen2.44705307
12MP0006292_abnormal_olfactory_placode2.21127082
13MP0001485_abnormal_pinna_reflex2.12566830
14MP0000678_abnormal_parathyroid_gland2.00866607
15MP0005410_abnormal_fertilization16.3376129
16MP0002822_catalepsy1.83213498
17MP0005623_abnormal_meninges_morphology1.82303154
18MP0002138_abnormal_hepatobiliary_system1.77443194
19MP0003718_maternal_effect1.73152226
20MP0002132_abnormal_respiratory_system1.54930412
21MP0002282_abnormal_trachea_morphology1.50051220
22MP0001486_abnormal_startle_reflex1.47118371
23MP0004233_abnormal_muscle_weight1.46885426
24MP0001905_abnormal_dopamine_level1.43593736
25MP0003646_muscle_fatigue1.43398594
26MP0002160_abnormal_reproductive_system1.43225297
27MP0002735_abnormal_chemical_nociception1.41203965
28MP0004859_abnormal_synaptic_plasticity1.40661991
29MP0001963_abnormal_hearing_physiology1.33230309
30MP0009745_abnormal_behavioral_response1.32708373
31MP0002163_abnormal_gland_morphology1.25191088
32MP0000955_abnormal_spinal_cord1.24280595
33MP0001765_abnormal_ion_homeostasis1.24100397
34MP0003880_abnormal_central_pattern1.23332963
35MP0002733_abnormal_thermal_nociception1.22468024
36MP0000026_abnormal_inner_ear1.21232467
37MP0002837_dystrophic_cardiac_calcinosis1.17694104
38MP0005310_abnormal_salivary_gland1.17595854
39MP0002249_abnormal_larynx_morphology1.17463411
40MP0000049_abnormal_middle_ear1.16703173
41MP0009053_abnormal_anal_canal1.15494658
42MP0002557_abnormal_social/conspecific_i1.12328562
43MP0006276_abnormal_autonomic_nervous1.12062505
44MP0001970_abnormal_pain_threshold1.09059167
45MP0009046_muscle_twitch1.06589372
46MP0002067_abnormal_sensory_capabilities1.04373408
47MP0001984_abnormal_olfaction1.03496573
48MP0003123_paternal_imprinting1.01072106
49MP0005084_abnormal_gallbladder_morpholo0.99932796
50MP0008995_early_reproductive_senescence0.97293804
51MP0005647_abnormal_sex_gland0.95116418
52MP0008789_abnormal_olfactory_epithelium0.93670737
53MP0005645_abnormal_hypothalamus_physiol0.93541168
54MP0004142_abnormal_muscle_tone0.92355920
55MP0008058_abnormal_DNA_repair0.90425726
56MP0003635_abnormal_synaptic_transmissio0.87185758
57MP0004085_abnormal_heartbeat0.85246460
58MP0001501_abnormal_sleep_pattern0.83502043
59MP0003137_abnormal_impulse_conducting0.81121656
60MP0002734_abnormal_mechanical_nocicepti0.80100445
61MP0003878_abnormal_ear_physiology0.79365754
62MP0005377_hearing/vestibular/ear_phenot0.79365754
63MP0002127_abnormal_cardiovascular_syste0.76491943
64MP0001188_hyperpigmentation0.75248506
65MP0005499_abnormal_olfactory_system0.75072855
66MP0005394_taste/olfaction_phenotype0.75072855
67MP0001529_abnormal_vocalization0.72605341
68MP0005646_abnormal_pituitary_gland0.72589180
69MP0002752_abnormal_somatic_nervous0.71312695
70MP0000230_abnormal_systemic_arterial0.71187173
71MP0002234_abnormal_pharynx_morphology0.71178504
72MP0002063_abnormal_learning/memory/cond0.70948223
73MP0005389_reproductive_system_phenotype0.70859142
74MP0002882_abnormal_neuron_morphology0.70487070
75MP0004885_abnormal_endolymph0.68352740
76MP0002064_seizures0.66433624
77MP0005636_abnormal_mineral_homeostasis0.65857997
78MP0003115_abnormal_respiratory_system0.65459182
79MP0002184_abnormal_innervation0.64698125
80MP0005332_abnormal_amino_acid0.64114341
81MP0001879_abnormal_lymphatic_vessel0.63539009
82MP0003011_delayed_dark_adaptation0.63484238
83MP0005535_abnormal_body_temperature0.63280563
84MP0008872_abnormal_physiological_respon0.63189373
85MP0003329_amyloid_beta_deposits0.60302730
86MP0000631_abnormal_neuroendocrine_gland0.57381795
87MP0000681_abnormal_thyroid_gland0.57320467
88MP0001324_abnormal_eye_pigmentation0.56768116
89MP0005666_abnormal_adipose_tissue0.56429368
90MP0008775_abnormal_heart_ventricle0.56390834
91MP0003121_genomic_imprinting0.55914983
92MP0005248_abnormal_Harderian_gland0.55812595
93MP0004036_abnormal_muscle_relaxation0.55439094
94MP0000569_abnormal_digit_pigmentation0.53213118
95MP0005551_abnormal_eye_electrophysiolog0.52383574
96MP0003699_abnormal_female_reproductive0.51543087
97MP0010094_abnormal_chromosome_stability0.51410798
98MP0000358_abnormal_cell_content/0.51217863
99MP0003950_abnormal_plasma_membrane0.49753269
100MP0001764_abnormal_homeostasis0.49678170
101MP0001293_anophthalmia0.48004427
102MP0002736_abnormal_nociception_after0.46456294
103MP0002269_muscular_atrophy0.46031852
104MP0005253_abnormal_eye_physiology0.44634071
105MP0002928_abnormal_bile_duct0.44292485
106MP0002102_abnormal_ear_morphology0.38218580
107MP0002971_abnormal_brown_adipose0.37368704
108MP0009115_abnormal_fat_cell0.36915472
109MP0003786_premature_aging0.34228771
110MP0003633_abnormal_nervous_system0.34077770
111MP0008057_abnormal_DNA_replication0.33836462
112MP0005391_vision/eye_phenotype0.33624232
113MP0004270_analgesia0.33006624
114MP0000534_abnormal_ureter_morphology0.32509391
115MP0001119_abnormal_female_reproductive0.31550667
116MP0006036_abnormal_mitochondrial_physio0.29890360
117MP0003879_abnormal_hair_cell0.29224179
118MP0000604_amyloidosis0.29190722
119MP0004811_abnormal_neuron_physiology0.29114266
120MP0005397_hematopoietic_system_phenotyp0.28628139
121MP0001545_abnormal_hematopoietic_system0.28628139
122MP0005423_abnormal_somatic_nervous0.28338595
123MP0003631_nervous_system_phenotype0.26917195
124MP0001968_abnormal_touch/_nociception0.26757203
125MP0004742_abnormal_vestibular_system0.26049612
126MP0003861_abnormal_nervous_system0.25777769
127MP0002152_abnormal_brain_morphology0.25726951
128MP0004019_abnormal_vitamin_homeostasis0.25035381
129MP0000751_myopathy0.24102664
130MP0004133_heterotaxia0.23763257
131MP0003111_abnormal_nucleus_morphology0.23664461
132MP0003942_abnormal_urinary_system0.23655487
133MP0009278_abnormal_bone_marrow0.23601235
134MP0002295_abnormal_pulmonary_circulatio0.23516904
135MP0004043_abnormal_pH_regulation0.22638456
136MP0002229_neurodegeneration0.20790908
137MP0002139_abnormal_hepatobiliary_system0.20231842
138MP0004145_abnormal_muscle_electrophysio0.20038387
139MP0003948_abnormal_gas_homeostasis0.19639077
140MP0008007_abnormal_cellular_replicative0.19492044
141MP0002169_no_abnormal_phenotype0.19312689
142MP0002873_normal_phenotype0.19146501
143MP0001727_abnormal_embryo_implantation0.19126940
144MP0008875_abnormal_xenobiotic_pharmacok0.18987129
145MP0001730_embryonic_growth_arrest0.18706886
146MP0002572_abnormal_emotion/affect_behav0.17854972
147MP0002092_abnormal_eye_morphology0.17304174
148MP0006072_abnormal_retinal_apoptosis0.16833487
149MP0006035_abnormal_mitochondrial_morpho0.16722243
150MP0001986_abnormal_taste_sensitivity0.16668594
151MP0005375_adipose_tissue_phenotype0.16124341
152MP0003045_fibrosis0.16122942
153MP0000920_abnormal_myelination0.16118134
154MP0005195_abnormal_posterior_eye0.15941185
155MP0008961_abnormal_basal_metabolism0.15721501
156MP0001440_abnormal_grooming_behavior0.15638889
157MP0003787_abnormal_imprinting0.14703515
158MP0008569_lethality_at_weaning0.13687472
159MP0004084_abnormal_cardiac_muscle0.13451777
160MP0000001_mammalian_phenotype0.13421804
161MP0002272_abnormal_nervous_system0.13037572

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34215513
2Abnormal respiratory motile cilium morphology (HP:0005938)9.31967330
3Abnormal respiratory epithelium morphology (HP:0012253)9.31967330
4Abnormal ciliary motility (HP:0012262)7.54862406
5Rhinitis (HP:0012384)7.50025046
6Severe visual impairment (HP:0001141)7.36522333
7Chronic bronchitis (HP:0004469)7.20562687
8Infertility (HP:0000789)6.75611784
9Nasal polyposis (HP:0100582)6.22755257
10Abnormality of the nasal mucosa (HP:0000433)5.10675123
11Abnormal rod and cone electroretinograms (HP:0008323)5.02640105
12Male infertility (HP:0003251)4.81859806
13Bronchitis (HP:0012387)4.64706388
14Bronchiectasis (HP:0002110)4.41916462
15Attenuation of retinal blood vessels (HP:0007843)4.26398240
16Chronic hepatic failure (HP:0100626)4.23751204
17Nephronophthisis (HP:0000090)4.22693610
18Bony spicule pigmentary retinopathy (HP:0007737)4.22020364
19Abnormality of macular pigmentation (HP:0008002)3.74266983
20Double outlet right ventricle (HP:0001719)3.58229773
21Congenital malformation of the right heart (HP:0011723)3.58229773
22Abnormal spermatogenesis (HP:0008669)3.54026941
23Recurrent sinusitis (HP:0011108)3.44885557
24Recurrent otitis media (HP:0000403)3.31922184
25Renal Fanconi syndrome (HP:0001994)3.31053720
26Abnormality of the renal medulla (HP:0100957)3.20446475
27Hyperkalemia (HP:0002153)3.09166411
28Progressive cerebellar ataxia (HP:0002073)2.98631553
29Tubulointerstitial nephritis (HP:0001970)2.97486974
30Myokymia (HP:0002411)2.94486323
31Recurrent bronchitis (HP:0002837)2.94135522
32Congenital stationary night blindness (HP:0007642)2.88678914
33Facial shape deformation (HP:0011334)2.81298108
34Potter facies (HP:0002009)2.81298108
35Abnormality of the aortic arch (HP:0012303)2.71731189
36Hyperthyroidism (HP:0000836)2.68693377
37Generalized aminoaciduria (HP:0002909)2.66661055
38Impulsivity (HP:0100710)2.66365890
39Unilateral renal agenesis (HP:0000122)2.63791292
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.62092540
41Molar tooth sign on MRI (HP:0002419)2.58698801
42Abnormality of midbrain morphology (HP:0002418)2.58698801
43Abnormality of dental color (HP:0011073)2.57397347
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54655235
45Sclerocornea (HP:0000647)2.51625355
46Polyuria (HP:0000103)2.49475569
47Gonadotropin excess (HP:0000837)2.49058966
48Medial flaring of the eyebrow (HP:0010747)2.48533916
49Tubular atrophy (HP:0000092)2.46624554
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46421628
51Resting tremor (HP:0002322)2.39467309
52Cholecystitis (HP:0001082)2.38824025
53Abnormal gallbladder physiology (HP:0012438)2.38824025
54Hypoplastic ischia (HP:0003175)2.38282711
55Tubulointerstitial abnormality (HP:0001969)2.38189747
56Pancreatic cysts (HP:0001737)2.37848917
57Abnormality of urine glucose concentration (HP:0011016)2.37629500
58Glycosuria (HP:0003076)2.37629500
59Enlarged epiphyses (HP:0010580)2.37523996
60Abnormality of renal resorption (HP:0011038)2.32412230
61Pendular nystagmus (HP:0012043)2.27629763
62Abnormality of the costochondral junction (HP:0000919)2.21510562
63Hypoplasia of the thymus (HP:0000778)2.21060274
64Azoospermia (HP:0000027)2.16406372
65Abnormality of the parathyroid morphology (HP:0011766)2.15948636
66Optic nerve hypoplasia (HP:0000609)2.15183426
67Hypophosphatemic rickets (HP:0004912)2.08328952
68Abnormality of potassium homeostasis (HP:0011042)2.04518869
69Dyschromatopsia (HP:0007641)2.04249782
70Cone-rod dystrophy (HP:0000548)2.01286090
71Spastic tetraparesis (HP:0001285)2.01178239
72Absent/shortened dynein arms (HP:0200106)13.5468508
73Dynein arm defect of respiratory motile cilia (HP:0012255)13.5468508
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1691806
75Transposition of the great arteries (HP:0001669)1.97451329
76Abnormal connection of the cardiac segments (HP:0011545)1.97451329
77Abnormal ventriculo-arterial connection (HP:0011563)1.97451329
78True hermaphroditism (HP:0010459)1.95451479
79Amelogenesis imperfecta (HP:0000705)1.95343150
80Osteomalacia (HP:0002749)1.94292113
81Fetal akinesia sequence (HP:0001989)1.92328768
82Amblyopia (HP:0000646)1.90893664
83Occipital encephalocele (HP:0002085)1.90455313
84Menstrual irregularities (HP:0000858)1.89693873
85Tetany (HP:0001281)1.89343831
86Postaxial foot polydactyly (HP:0001830)1.89162144
87Type II lissencephaly (HP:0007260)1.88621822
88Abnormality of the ischium (HP:0003174)1.88444613
89Decreased central vision (HP:0007663)1.86876555
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86070994
91Heterotopia (HP:0002282)1.82002999
92Choroideremia (HP:0001139)1.81962194
93Hypoplastic left heart (HP:0004383)1.80347516
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79951101
95Tubulointerstitial fibrosis (HP:0005576)1.79158364
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78873428
97Optic disc pallor (HP:0000543)1.77201053
98Portal hypertension (HP:0001409)1.77153642
99Stage 5 chronic kidney disease (HP:0003774)1.76178338
100Bile duct proliferation (HP:0001408)1.74835458
101Abnormal biliary tract physiology (HP:0012439)1.74835458
102Bulbous nose (HP:0000414)1.74724010
103Acute necrotizing encephalopathy (HP:0006965)1.74563284
104Intellectual disability, moderate (HP:0002342)1.73843037
105Congenital hepatic fibrosis (HP:0002612)1.68877882
106Muscle fiber atrophy (HP:0100295)1.68230252
107Preauricular pit (HP:0004467)1.67500201
108Abnormal drinking behavior (HP:0030082)1.66746835
109Polydipsia (HP:0001959)1.66746835
110Bell-shaped thorax (HP:0001591)1.65866337
111Short ribs (HP:0000773)1.63253153
112Abnormality of the renal cortex (HP:0011035)1.62099708
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60849503
114Abnormality of renal excretion (HP:0011036)1.58681278
115Fibular hypoplasia (HP:0003038)1.57912343
116Abnormality of permanent molar morphology (HP:0011071)1.57549461
117Abnormality of the dental root (HP:0006486)1.57549461
118Taurodontia (HP:0000679)1.57549461
119Asymmetric septal hypertrophy (HP:0001670)1.56426267
120Oculomotor apraxia (HP:0000657)1.55602854
121Abnormality of the lower motor neuron (HP:0002366)1.55105860
122Hemorrhage of the eye (HP:0011885)1.51153550
123Chronic sinusitis (HP:0011109)1.48903942
124Abnormality of dentin (HP:0010299)1.48470722
125Postaxial hand polydactyly (HP:0001162)1.47759488
126Abnormality of molar (HP:0011077)1.46300861
127Abnormality of molar morphology (HP:0011070)1.46300861
128Renal dysplasia (HP:0000110)1.46017853
129Aplasia/Hypoplasia of the lens (HP:0008063)1.45773819
130Abnormality of the dental pulp (HP:0006479)1.44945299
131Neurofibrillary tangles (HP:0002185)1.44825232
132Gait imbalance (HP:0002141)1.44021862
133Cystic liver disease (HP:0006706)1.43712329
134Congenital primary aphakia (HP:0007707)1.43347556
135Absent frontal sinuses (HP:0002688)1.41299136
136Microglossia (HP:0000171)1.38918494
137Hemiparesis (HP:0001269)1.38473313
138Pancreatic fibrosis (HP:0100732)1.38142618
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.38080061
140J-shaped sella turcica (HP:0002680)1.37791231
141Deformed sella turcica (HP:0002681)1.37501402
142Bundle branch block (HP:0011710)1.34617914
143Amyotrophic lateral sclerosis (HP:0007354)1.34204413
144Facial cleft (HP:0002006)1.33673019
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.31367749
146Abnormal urine output (HP:0012590)1.27876117
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.26425991
148Absent epiphyses (HP:0010577)1.26425991
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22213218
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.21944259
151Cerebellar dysplasia (HP:0007033)1.21836065
152Constricted visual fields (HP:0001133)1.21766164
153Cerebral inclusion bodies (HP:0100314)1.21001506
154Nephrogenic diabetes insipidus (HP:0009806)1.20811399
155Short thorax (HP:0010306)1.20580522
156Abnormality of saccadic eye movements (HP:0000570)1.19882218
157Broad distal phalanx of finger (HP:0009836)1.18180403
158Nephropathy (HP:0000112)1.18020883
159Truncal obesity (HP:0001956)1.17631585
160Sensory axonal neuropathy (HP:0003390)1.16490087
161Easy fatigability (HP:0003388)1.15981871
162Pachygyria (HP:0001302)1.15359569
163Abnormality of ocular smooth pursuit (HP:0000617)1.15072846
164Supernumerary spleens (HP:0009799)1.14941485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.55460194
2PDK48.55460194
3TESK15.55945497
4PDK25.52674285
5PRKD35.11338506
6ICK4.04327092
7MAP4K23.58646826
8INSRR3.23644763
9DDR23.13927046
10PLK22.59404038
11FRK2.32463121
12PNCK2.31805899
13PTK2B2.19927772
14WNK42.18216728
15STK392.11886691
16BRD42.07267256
17STK381.57525959
18DYRK1B1.53321344
19PIK3CG1.43693140
20SIK21.43660619
21NEK21.39143829
22ZAK1.38069321
23ADRBK21.38039815
24AKT31.33887524
25TAF11.29565852
26DYRK21.27706016
27MAP3K91.21090774
28NUAK11.18851319
29CASK1.13789341
30PDK11.10917211
31NTRK30.96886101
32VRK20.91920634
33CDK70.91580195
34TYRO30.90876377
35STK160.90471052
36WNK10.87114396
37TLK10.86331790
38OXSR10.85661463
39DYRK30.83599148
40CAMK10.81522379
41CAMK1D0.78809563
42GRK10.77033085
43MAPK150.73605342
44TXK0.73259993
45CDK190.72390338
46TNIK0.70518112
47BCKDK0.70012945
48IRAK10.68889373
49STK30.67682439
50CAMK1G0.66447173
51PASK0.65721142
52MAP2K60.63847929
53PDPK10.62288031
54TESK20.60752100
55RPS6KA20.59774587
56ABL20.59292035
57CCNB10.58931287
58RIPK40.58667080
59CHEK20.57540058
60LMTK20.57382266
61TTK0.57171434
62MAP3K110.55172785
63VRK10.52366412
64TIE10.50770473
65MST1R0.50285541
66SGK2230.49887158
67SGK4940.49887158
68CSNK1G30.46246259
69MAPK130.45934205
70PINK10.44854684
71EEF2K0.44038986
72ACVR1B0.43944862
73STK38L0.43544541
74RPS6KA60.42449463
75CSNK1G20.41584414
76PAK10.41226590
77TNK20.40273288
78CHEK10.40236920
79NTRK20.38491937
80PRKAA20.35721672
81DMPK0.35714282
82MUSK0.35622988
83IRAK20.35503504
84UHMK10.34322218
85PRKCE0.34015446
86PHKG20.33706441
87PHKG10.33706441
88MKNK20.33506565
89MINK10.32892937
90PLK40.32335049
91RPS6KL10.32303407
92RPS6KC10.32303407
93WEE10.31149792
94NEK60.30163237
95SGK10.29401766
96PRKCG0.29360874
97MARK20.29221483
98MAPKAPK50.28109613
99CDK80.28062647
100ATM0.27949141
101CSNK1A10.27218862
102PAK20.26560316
103MTOR0.24888840
104ATR0.22072853
105PAK40.20981037
106PRKAA10.19778440
107CDC70.18486212
108CAMKK10.17927529
109BRSK20.17549751
110MAP3K100.17325118
111RPS6KB10.15741564
112PRKCZ0.14307793
113PRKCQ0.12648228
114PLK10.12400209
115PKN10.11713754
116CDK150.11404201
117CSNK1D0.09899660
118BRAF0.09606708
119MAP3K40.09447458
120MARK30.09217212
121CDK180.08852576
122BRSK10.08657637
123GSK3B0.08205439
124CAMK2A0.07912743
125CDK11A0.07711898
126PRKG10.06993634
127CDK140.05587791
128STK110.05495940
129CSNK2A10.05445137
130CDK120.04522411
131RPS6KA10.04518679
132CDK10.04247965
133WNK30.04191792
134PRKG20.03688292
135CDK20.03309207
136PRKACG0.03195283
137CSNK2A20.02650346
138STK100.02143795
139MAPK80.01801128
140PAK60.01594171
141EPHB10.01500225
142BMPR1B0.01427938
143PRKCB0.01329444
144PRKACB0.00505765
145EGFR0.00290352
146PRKCA0.00180550
147PDGFRB-0.0215683
148PRKDC-0.0139864
149PRKACA-0.0113858
150MAP3K5-0.0079428
151PRKCD-0.0076305
152MARK1-0.0057787
153MAP2K7-0.0040844
154AURKA-0.0025783
155CDK6-0.0012022
156RPS6KA3-0.0011732

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.01669910
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60081911
3Fatty acid biosynthesis_Homo sapiens_hsa000614.24833681
4Vitamin B6 metabolism_Homo sapiens_hsa007503.59817333
5Pyruvate metabolism_Homo sapiens_hsa006203.57319388
6Olfactory transduction_Homo sapiens_hsa047403.11297111
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91692919
8Linoleic acid metabolism_Homo sapiens_hsa005912.80969468
9Propanoate metabolism_Homo sapiens_hsa006402.76235342
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66340454
11Butanoate metabolism_Homo sapiens_hsa006502.63291101
12Glucagon signaling pathway_Homo sapiens_hsa049222.58173102
13Sulfur relay system_Homo sapiens_hsa041222.39288460
14Oxidative phosphorylation_Homo sapiens_hsa001902.36779123
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30378618
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.29920705
17Basal transcription factors_Homo sapiens_hsa030222.22401663
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03123083
19Glycerolipid metabolism_Homo sapiens_hsa005611.98799733
20Ribosome_Homo sapiens_hsa030101.96506716
21Phototransduction_Homo sapiens_hsa047441.95906990
22Dorso-ventral axis formation_Homo sapiens_hsa043201.87146951
23PPAR signaling pathway_Homo sapiens_hsa033201.86798471
24Selenocompound metabolism_Homo sapiens_hsa004501.83802969
25Oocyte meiosis_Homo sapiens_hsa041141.81843207
26Parkinsons disease_Homo sapiens_hsa050121.71814026
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.69640695
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69151339
29Pentose phosphate pathway_Homo sapiens_hsa000301.68685346
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63387497
31Nicotine addiction_Homo sapiens_hsa050331.63245467
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.61676054
33Fructose and mannose metabolism_Homo sapiens_hsa000511.57602969
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56178975
35Mineral absorption_Homo sapiens_hsa049781.53790658
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51892858
37Amphetamine addiction_Homo sapiens_hsa050311.49607576
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49344527
39Carbon metabolism_Homo sapiens_hsa012001.40597300
40Ether lipid metabolism_Homo sapiens_hsa005651.39290790
41Cardiac muscle contraction_Homo sapiens_hsa042601.36977045
42Fatty acid metabolism_Homo sapiens_hsa012121.32902432
43Fanconi anemia pathway_Homo sapiens_hsa034601.30450846
44Fatty acid degradation_Homo sapiens_hsa000711.27813914
45Morphine addiction_Homo sapiens_hsa050321.26665695
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26036453
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24260305
48Fat digestion and absorption_Homo sapiens_hsa049751.22829777
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22346470
50Type I diabetes mellitus_Homo sapiens_hsa049401.22193001
51Huntingtons disease_Homo sapiens_hsa050161.22081650
52Phenylalanine metabolism_Homo sapiens_hsa003601.19655126
53Arginine and proline metabolism_Homo sapiens_hsa003301.18234262
54Alzheimers disease_Homo sapiens_hsa050101.18154487
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16497715
56Renin secretion_Homo sapiens_hsa049241.16431345
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16419461
58Allograft rejection_Homo sapiens_hsa053301.16373490
59Autoimmune thyroid disease_Homo sapiens_hsa053201.14872124
60RNA polymerase_Homo sapiens_hsa030201.13871231
61Antigen processing and presentation_Homo sapiens_hsa046121.10011959
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.08336132
63Peroxisome_Homo sapiens_hsa041461.03223611
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03123468
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02657245
66mRNA surveillance pathway_Homo sapiens_hsa030151.00593078
67Purine metabolism_Homo sapiens_hsa002300.98704744
68Nitrogen metabolism_Homo sapiens_hsa009100.97646399
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96977830
70Biosynthesis of amino acids_Homo sapiens_hsa012300.95673760
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95500012
72Collecting duct acid secretion_Homo sapiens_hsa049660.92109557
73RNA transport_Homo sapiens_hsa030130.91173108
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90480227
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88018330
76Retinol metabolism_Homo sapiens_hsa008300.87341533
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.87051387
78Glutathione metabolism_Homo sapiens_hsa004800.83047282
79Insulin secretion_Homo sapiens_hsa049110.81401061
80GABAergic synapse_Homo sapiens_hsa047270.80883355
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78774270
82Homologous recombination_Homo sapiens_hsa034400.77565781
83Bile secretion_Homo sapiens_hsa049760.77435676
84Chemical carcinogenesis_Homo sapiens_hsa052040.77167072
85Estrogen signaling pathway_Homo sapiens_hsa049150.75663839
86Protein export_Homo sapiens_hsa030600.75297044
87Long-term potentiation_Homo sapiens_hsa047200.75276162
88Hedgehog signaling pathway_Homo sapiens_hsa043400.74786504
89Serotonergic synapse_Homo sapiens_hsa047260.72491515
90Thyroid hormone synthesis_Homo sapiens_hsa049180.72188114
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71453740
92Tryptophan metabolism_Homo sapiens_hsa003800.70348359
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.70066327
94Graft-versus-host disease_Homo sapiens_hsa053320.70053270
95Renin-angiotensin system_Homo sapiens_hsa046140.68180160
96Arachidonic acid metabolism_Homo sapiens_hsa005900.67351529
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66738887
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66710739
99beta-Alanine metabolism_Homo sapiens_hsa004100.66187473
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65910390
101Tyrosine metabolism_Homo sapiens_hsa003500.63655724
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62351483
103Calcium signaling pathway_Homo sapiens_hsa040200.62118209
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61420988
105Synaptic vesicle cycle_Homo sapiens_hsa047210.57248635
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.56867251
107Cholinergic synapse_Homo sapiens_hsa047250.56674098
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56315691
109One carbon pool by folate_Homo sapiens_hsa006700.56239833
110Salivary secretion_Homo sapiens_hsa049700.56086615
111Inositol phosphate metabolism_Homo sapiens_hsa005620.54699114
112Taste transduction_Homo sapiens_hsa047420.53875256
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52706447
114Pancreatic secretion_Homo sapiens_hsa049720.50450695
115Legionellosis_Homo sapiens_hsa051340.48969113
116Base excision repair_Homo sapiens_hsa034100.48713782
117ABC transporters_Homo sapiens_hsa020100.47926220
118Gastric acid secretion_Homo sapiens_hsa049710.47642102
119Protein digestion and absorption_Homo sapiens_hsa049740.47275287
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45757693
121Endocytosis_Homo sapiens_hsa041440.45475300
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43221686
123AMPK signaling pathway_Homo sapiens_hsa041520.42677585
124Sulfur metabolism_Homo sapiens_hsa009200.42665010
125Arginine biosynthesis_Homo sapiens_hsa002200.41669354
126Oxytocin signaling pathway_Homo sapiens_hsa049210.40436366
127Circadian entrainment_Homo sapiens_hsa047130.40036114
128Metabolic pathways_Homo sapiens_hsa011000.39930855
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39368538
130Caffeine metabolism_Homo sapiens_hsa002320.38966762
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.38678341
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.38383238
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38103998
134cAMP signaling pathway_Homo sapiens_hsa040240.36071545
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35129788
136Basal cell carcinoma_Homo sapiens_hsa052170.32716120
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32578538
138Systemic lupus erythematosus_Homo sapiens_hsa053220.32492468
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31005143
140Proteasome_Homo sapiens_hsa030500.29154845
141Regulation of autophagy_Homo sapiens_hsa041400.29000865
142VEGF signaling pathway_Homo sapiens_hsa043700.28499717
143Cocaine addiction_Homo sapiens_hsa050300.25428143
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23561292
145Glutamatergic synapse_Homo sapiens_hsa047240.16664377
146Pyrimidine metabolism_Homo sapiens_hsa002400.13873772
147Alcoholism_Homo sapiens_hsa050340.12245477
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08883142
149Type II diabetes mellitus_Homo sapiens_hsa049300.07564654
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.06944561
151RNA degradation_Homo sapiens_hsa030180.06900727
152Wnt signaling pathway_Homo sapiens_hsa043100.05928539
153HIF-1 signaling pathway_Homo sapiens_hsa040660.04609645
154N-Glycan biosynthesis_Homo sapiens_hsa005100.03729016

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