FAM71E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.99288669
2multicellular organism reproduction (GO:0032504)9.78164765
3epithelial cilium movement (GO:0003351)9.67545967
4spermatid development (GO:0007286)9.65693816
5axonemal dynein complex assembly (GO:0070286)9.35931008
6motile cilium assembly (GO:0044458)9.24748196
7plasma membrane fusion (GO:0045026)8.90050907
8reproduction (GO:0000003)8.89163279
9regulation of cilium movement (GO:0003352)8.43337962
10cilium movement (GO:0003341)7.90945792
11negative regulation of inclusion body assembly (GO:0090084)7.24842475
12sperm capacitation (GO:0048240)7.24413125
13organic cation transport (GO:0015695)6.94376685
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.83709249
15spermatogenesis (GO:0007283)6.83344636
16cilium or flagellum-dependent cell motility (GO:0001539)6.81984708
17male gamete generation (GO:0048232)6.80647588
18single fertilization (GO:0007338)6.79435736
19synaptonemal complex organization (GO:0070193)6.57771321
20synaptonemal complex assembly (GO:0007130)6.53625937
21spermatid nucleus differentiation (GO:0007289)6.48498749
22regulation of inclusion body assembly (GO:0090083)6.36309966
23gamete generation (GO:0007276)6.25028245
24microtubule depolymerization (GO:0007019)6.23668047
25male meiosis (GO:0007140)6.20408937
26calcium ion-dependent exocytosis (GO:0017156)6.05388797
27single strand break repair (GO:0000012)5.90720390
28sexual reproduction (GO:0019953)5.77658078
29fertilization (GO:0009566)5.74979092
30piRNA metabolic process (GO:0034587)5.69998042
31chromosome condensation (GO:0030261)5.56632814
32DNA packaging (GO:0006323)5.29985600
33germ cell development (GO:0007281)5.25506857
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.14136926
35glycerol ether metabolic process (GO:0006662)5.10180573
36microtubule severing (GO:0051013)5.08354988
37cell recognition (GO:0008037)5.03234824
38regulation of microtubule-based movement (GO:0060632)5.00425613
39multicellular organismal reproductive process (GO:0048609)4.89202832
40ventricular system development (GO:0021591)4.72057004
41ether metabolic process (GO:0018904)4.70271642
42chromosome organization involved in meiosis (GO:0070192)4.29516840
43seminiferous tubule development (GO:0072520)4.27489946
44protein K11-linked deubiquitination (GO:0035871)4.18102228
45sequestering of actin monomers (GO:0042989)4.18044888
46left/right pattern formation (GO:0060972)4.10462963
47proteasome assembly (GO:0043248)4.00100910
48male meiosis I (GO:0007141)3.97990528
49multicellular organismal development (GO:0007275)3.97439482
50chromatin remodeling at centromere (GO:0031055)3.92207328
51DNA methylation involved in gamete generation (GO:0043046)3.88810231
52CENP-A containing nucleosome assembly (GO:0034080)3.84487772
53ribosomal small subunit assembly (GO:0000028)3.82569970
54viral transcription (GO:0019083)3.76640632
55histone exchange (GO:0043486)3.67750630
56translational termination (GO:0006415)3.66085971
57meiotic nuclear division (GO:0007126)3.62053792
58chaperone-mediated protein transport (GO:0072321)3.60754756
59protein polyglutamylation (GO:0018095)3.59919428
60positive regulation of macrophage activation (GO:0043032)3.52352160
61RNA localization (GO:0006403)3.51515111
62chaperone-mediated protein complex assembly (GO:0051131)3.51241273
63negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.50005483
64regulation of meiosis I (GO:0060631)3.47283333
65maturation of SSU-rRNA (GO:0030490)3.46049181
66polyamine biosynthetic process (GO:0006596)3.34333857
67DNA replication checkpoint (GO:0000076)3.30034200
68translational elongation (GO:0006414)3.24949752
69resolution of meiotic recombination intermediates (GO:0000712)3.22035274
70meiotic cell cycle process (GO:1903046)3.19450548
71regulation of mitochondrial translation (GO:0070129)3.19222640
72glycolytic process (GO:0006096)3.19148168
73chromatin silencing (GO:0006342)3.19058670
74protein localization to cilium (GO:0061512)3.18700575
75pseudouridine synthesis (GO:0001522)3.18497494
76mitotic metaphase plate congression (GO:0007080)3.16693533
77mitotic chromosome condensation (GO:0007076)3.15952380
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.15470397
79microtubule polymerization or depolymerization (GO:0031109)3.15390807
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13665016
81intraciliary transport (GO:0042073)3.12426366
82RNA destabilization (GO:0050779)3.11729961
83cilium organization (GO:0044782)3.08609913
84translational initiation (GO:0006413)3.08415836
85cotranslational protein targeting to membrane (GO:0006613)3.07519962
86protein refolding (GO:0042026)3.07046122
87meiosis I (GO:0007127)3.05413991
88negative regulation of DNA-templated transcription, elongation (GO:0032785)3.05354483
89protein-DNA complex disassembly (GO:0032986)3.05352939
90nucleosome disassembly (GO:0006337)3.05352939
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02499630
92protein targeting to ER (GO:0045047)2.99939791
93cilium assembly (GO:0042384)2.99755773
94axoneme assembly (GO:0035082)2.97855825
95genitalia morphogenesis (GO:0035112)2.96719337
96cilium morphogenesis (GO:0060271)2.95805166
97cellular protein complex disassembly (GO:0043624)2.94721540
98rRNA modification (GO:0000154)2.93096078
99polyol catabolic process (GO:0046174)2.92831196
100DNA replication-independent nucleosome organization (GO:0034724)2.90979183
101DNA replication-independent nucleosome assembly (GO:0006336)2.90979183
102regulation of spindle checkpoint (GO:0090231)2.89557720
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87972574
104cellular component assembly involved in morphogenesis (GO:0010927)2.87228695
105ribosomal small subunit biogenesis (GO:0042274)2.87126500
106nucleus organization (GO:0006997)2.84985234
107protein localization to endoplasmic reticulum (GO:0070972)2.84846548
108cullin deneddylation (GO:0010388)2.84810111
109calcium ion import (GO:0070509)2.84527824
110nucleoside diphosphate phosphorylation (GO:0006165)2.82859431
111regulation of cilium assembly (GO:1902017)2.82412048
112viral life cycle (GO:0019058)2.80041584
113membrane protein intracellular domain proteolysis (GO:0031293)2.78629232
114pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77495149
115centriole replication (GO:0007099)2.77443771
116lactate metabolic process (GO:0006089)2.77317268
117interferon-gamma secretion (GO:0072643)2.73982905
118mitochondrion degradation (GO:0000422)2.73155989
119meiotic chromosome segregation (GO:0045132)2.73020091
120ribosomal large subunit biogenesis (GO:0042273)2.71551677
121DNA damage response, detection of DNA damage (GO:0042769)2.71493571
122protein complex disassembly (GO:0043241)2.70397535
123regulation of retinoic acid receptor signaling pathway (GO:0048385)2.66577525
124protein targeting to mitochondrion (GO:0006626)2.66275086
125microtubule-based movement (GO:0007018)2.65666483
126protein deneddylation (GO:0000338)2.65473795
127cellular biogenic amine biosynthetic process (GO:0042401)2.64505586
128amine biosynthetic process (GO:0009309)2.64505586
129establishment of integrated proviral latency (GO:0075713)2.63520105
130histone arginine methylation (GO:0034969)2.62728705
131DNA strand elongation involved in DNA replication (GO:0006271)2.61586504
132macromolecular complex disassembly (GO:0032984)2.59887576
133amino-acid betaine transport (GO:0015838)2.59670752
134carnitine transport (GO:0015879)2.59670752
135iron-sulfur cluster assembly (GO:0016226)2.58992700
136metallo-sulfur cluster assembly (GO:0031163)2.58992700
137termination of RNA polymerase III transcription (GO:0006386)2.57466366
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.57466366
139establishment of protein localization to mitochondrion (GO:0072655)2.57407232
140L-serine metabolic process (GO:0006563)2.56945540
141regulation of centriole replication (GO:0046599)2.56459169
142alditol metabolic process (GO:0019400)2.56299461
143maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55902450
144GTP biosynthetic process (GO:0006183)2.55546696
145establishment of protein localization to mitochondrial membrane (GO:0090151)2.54553434
146DNA strand elongation (GO:0022616)2.54530388
147rRNA processing (GO:0006364)2.54459540
148monoubiquitinated protein deubiquitination (GO:0035520)2.53721039
149meiotic cell cycle (GO:0051321)2.53651837
150protein complex biogenesis (GO:0070271)2.52015756
151rRNA metabolic process (GO:0016072)2.51961282
152ribonucleoprotein complex biogenesis (GO:0022613)2.51677646
153ncRNA 3-end processing (GO:0043628)2.49514927
154respiratory chain complex IV assembly (GO:0008535)2.49010047
155cellular component biogenesis (GO:0044085)2.47809112
156telomere maintenance via semi-conservative replication (GO:0032201)2.47213427
157translation (GO:0006412)2.46714017
158DNA replication initiation (GO:0006270)2.46621833
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.45297411
160NADH dehydrogenase complex assembly (GO:0010257)2.45297411
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45297411
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.45116737
163protein localization to mitochondrion (GO:0070585)2.44961125
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.44724903
165DNA double-strand break processing (GO:0000729)2.44241174
166spliceosomal snRNP assembly (GO:0000387)2.42792911
167histone mRNA metabolic process (GO:0008334)2.42699556
168mitochondrial respiratory chain complex assembly (GO:0033108)2.42440705
169synapsis (GO:0007129)2.42130146
170regulation of double-strand break repair via homologous recombination (GO:0010569)2.41502118
171negative regulation of gene expression, epigenetic (GO:0045814)2.41497358
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.40572063
173translesion synthesis (GO:0019985)2.40444962
174mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39333594
175ribosome biogenesis (GO:0042254)2.38529866
176formation of translation preinitiation complex (GO:0001731)2.38283959
177protein K6-linked ubiquitination (GO:0085020)2.37134761
178cell wall macromolecule catabolic process (GO:0016998)14.4723989
179cell wall macromolecule metabolic process (GO:0044036)14.4723989
180sperm motility (GO:0030317)14.2330446
181acrosome reaction (GO:0007340)12.6759410
182fusion of sperm to egg plasma membrane (GO:0007342)11.6325259
183acrosome assembly (GO:0001675)11.2958974
184sperm-egg recognition (GO:0035036)11.1228473
185binding of sperm to zona pellucida (GO:0007339)10.1627226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.50445798
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.52199638
3EZH2_22144423_ChIP-Seq_EOC_Human4.15766841
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52949904
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.51625477
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.47431693
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43408481
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22159925
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08952082
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.06765539
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97195837
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89172314
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.88118453
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86250553
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80679979
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.68075786
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.67890132
18E2F7_22180533_ChIP-Seq_HELA_Human2.66275036
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.60534867
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52121058
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51158875
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45125463
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35855778
24VDR_22108803_ChIP-Seq_LS180_Human2.34989347
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11451552
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09917738
27GATA1_26923725_Chip-Seq_HPCs_Mouse2.09186618
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01715819
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94447547
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93918873
31TTF2_22483619_ChIP-Seq_HELA_Human1.92139634
32XRN2_22483619_ChIP-Seq_HELA_Human1.87723463
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87651512
34GABP_19822575_ChIP-Seq_HepG2_Human1.86979798
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84392882
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.83944412
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82262153
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82051104
39ZNF274_21170338_ChIP-Seq_K562_Hela1.82032066
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80519610
41* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77150505
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73841455
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73201818
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73133391
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.72713574
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71992939
47REST_21632747_ChIP-Seq_MESCs_Mouse1.70439965
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69125694
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.68363734
50DCP1A_22483619_ChIP-Seq_HELA_Human1.64418804
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63080820
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59373398
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58495582
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58122444
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57202369
56KDM2B_26808549_Chip-Seq_REH_Human1.55488104
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53486483
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.53049623
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52453291
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.51712780
61STAT1_17558387_ChIP-Seq_HELA_Human1.50505531
62VDR_23849224_ChIP-Seq_CD4+_Human1.49880066
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.43570244
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.42965048
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42700433
66FOXP3_21729870_ChIP-Seq_TREG_Human1.42118109
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42072988
68MYC_18940864_ChIP-ChIP_HL60_Human1.41508016
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41052602
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.37276296
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.36740669
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34666960
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34635093
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34391045
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34107804
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33768515
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33765796
78TAF15_26573619_Chip-Seq_HEK293_Human1.33384609
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31967562
80CBP_20019798_ChIP-Seq_JUKART_Human1.31967562
81KDM5A_27292631_Chip-Seq_BREAST_Human1.31058296
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30553024
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29138802
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27289492
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27227348
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26918446
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.26848905
88P53_21459846_ChIP-Seq_SAOS-2_Human1.26428808
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26106223
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26106223
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.23092266
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.22639953
93GF1_26923725_Chip-Seq_HPCs_Mouse1.22147348
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21712109
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.20745577
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20293392
97LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19883534
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19802392
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19802392
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19802392
101KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19714168
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17951013
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.17721473
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17284114
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15729975
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14090108
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13870444
108RNF2_27304074_Chip-Seq_NSC_Mouse1.13372912
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12126816
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.12081352
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12031986
112* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11591307
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10895318
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10811211
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10732637
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10723968
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10351963
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08538670
119ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08446851
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07689141
121P53_22387025_ChIP-Seq_ESCs_Mouse1.06513414
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06377064
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06284960
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.06216451
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05562603
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.04867510
127SPI1_26923725_Chip-Seq_HPCs_Mouse1.04839310
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04793158
129SOX9_26525672_Chip-Seq_HEART_Mouse1.04727899
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.04437582
131IRF1_19129219_ChIP-ChIP_H3396_Human1.03937298
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02916586
133FOXP1_21924763_ChIP-Seq_HESCs_Human1.02575702
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02359011
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.01493921
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.01355747
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01289326
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00932495
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.99423808
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98180963
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97685150
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.97526416
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97497050
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97323022
145CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97313448
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96380204
147GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96361368
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95455347
149P300_18555785_Chip-Seq_ESCs_Mouse0.95334608
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94942321
151ERG_20517297_ChIP-Seq_VCAP_Human0.94852790
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93646718
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93452090
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93259179
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93183654
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.92887485
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92557124
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92036748
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92027678
160AR_21909140_ChIP-Seq_LNCAP_Human0.91720168
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.91418163
162SOX2_16153702_ChIP-ChIP_HESCs_Human0.90646747
163NANOG_16153702_ChIP-ChIP_HESCs_Human0.90638799
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90288374
165PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90229728
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89976538
167PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89622172
168SMAD3_21741376_ChIP-Seq_ESCs_Human0.89246343
169FUS_26573619_Chip-Seq_HEK293_Human0.88519044
170CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87551495
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86830077
172E2F1_21310950_ChIP-Seq_MCF-7_Human0.86218123
173ELK1_19687146_ChIP-ChIP_HELA_Human0.83874498
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81568931
175POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81039575
176NOTCH1_21737748_ChIP-Seq_TLL_Human0.80478019
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79865166
178BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79831079
179SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77653327
180DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77372564
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74541275
182TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74160889
183NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74144710
184CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73379182
185CTCF_20526341_ChIP-Seq_ESCs_Human0.73019397
186KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72763515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.74931635
2MP0001929_abnormal_gametogenesis5.17493537
3MP0008877_abnormal_DNA_methylation3.17677456
4MP0002161_abnormal_fertility/fecundity3.11045780
5MP0002210_abnormal_sex_determination3.05307603
6MP0003718_maternal_effect3.04587053
7MP0003693_abnormal_embryo_hatching2.91506790
8MP0005670_abnormal_white_adipose2.91432966
9MP0001145_abnormal_male_reproductive2.60156021
10MP0009379_abnormal_foot_pigmentation2.41987584
11MP0000653_abnormal_sex_gland2.25099555
12MP0005410_abnormal_fertilization15.6077535
13MP0010094_abnormal_chromosome_stability1.99226385
14MP0003123_paternal_imprinting1.96656424
15MP0003121_genomic_imprinting1.95730970
16MP0003077_abnormal_cell_cycle1.93485186
17MP0010030_abnormal_orbit_morphology1.88786015
18MP0002160_abnormal_reproductive_system1.81876753
19MP0001984_abnormal_olfaction1.76239819
20MP0003111_abnormal_nucleus_morphology1.74575269
21MP0004957_abnormal_blastocyst_morpholog1.74355156
22MP0003122_maternal_imprinting1.71074946
23MP0002653_abnormal_ependyma_morphology1.69671295
24MP0008932_abnormal_embryonic_tissue1.68738583
25MP0002234_abnormal_pharynx_morphology1.66138553
26MP0003136_yellow_coat_color1.59555279
27MP0001188_hyperpigmentation1.58280964
28MP0004233_abnormal_muscle_weight1.52026034
29MP0004142_abnormal_muscle_tone1.45280725
30MP0003186_abnormal_redox_activity1.41316511
31MP0002249_abnormal_larynx_morphology1.38354534
32MP0005551_abnormal_eye_electrophysiolog1.35888349
33MP0002822_catalepsy1.29808969
34MP0003119_abnormal_digestive_system1.24954716
35MP0006035_abnormal_mitochondrial_morpho1.21569236
36MP0008007_abnormal_cellular_replicative1.19387438
37MP0003646_muscle_fatigue1.18893287
38MP0000778_abnormal_nervous_system1.18789430
39MP0003880_abnormal_central_pattern1.18327757
40MP0001346_abnormal_lacrimal_gland1.18292244
41MP0002736_abnormal_nociception_after1.09324516
42MP0003937_abnormal_limbs/digits/tail_de1.09195484
43MP0003890_abnormal_embryonic-extraembry1.04030187
44MP0003938_abnormal_ear_development1.03842392
45MP0001765_abnormal_ion_homeostasis1.03759347
46MP0003786_premature_aging1.00123712
47MP0009046_muscle_twitch0.98883638
48MP0005253_abnormal_eye_physiology0.98828944
49MP0002233_abnormal_nose_morphology0.96944258
50MP0006072_abnormal_retinal_apoptosis0.95982914
51MP0001119_abnormal_female_reproductive0.95379838
52MP0001502_abnormal_circadian_rhythm0.94828443
53MP0005501_abnormal_skin_physiology0.92166421
54MP0002697_abnormal_eye_size0.91909987
55MP0002084_abnormal_developmental_patter0.89045858
56MP0003183_abnormal_peptide_metabolism0.88930801
57MP0004859_abnormal_synaptic_plasticity0.88885166
58MP0001730_embryonic_growth_arrest0.88299278
59MP0005389_reproductive_system_phenotype0.88022184
60MP0000537_abnormal_urethra_morphology0.87832442
61MP0002085_abnormal_embryonic_tissue0.87523386
62MP0005367_renal/urinary_system_phenotyp0.86613505
63MP0000516_abnormal_urinary_system0.86613505
64MP0001905_abnormal_dopamine_level0.86506077
65MP0000678_abnormal_parathyroid_gland0.85438650
66MP0001968_abnormal_touch/_nociception0.83253931
67MP0002282_abnormal_trachea_morphology0.82825582
68MP0001286_abnormal_eye_development0.82063475
69MP0001324_abnormal_eye_pigmentation0.82028296
70MP0008789_abnormal_olfactory_epithelium0.81401992
71MP0000350_abnormal_cell_proliferation0.79064760
72MP0005647_abnormal_sex_gland0.78910827
73MP0005395_other_phenotype0.78354605
74MP0003567_abnormal_fetal_cardiomyocyte0.77680546
75MP0005623_abnormal_meninges_morphology0.75187127
76MP0005257_abnormal_intraocular_pressure0.73399975
77MP0002111_abnormal_tail_morphology0.73390731
78MP0003011_delayed_dark_adaptation0.72926361
79MP0003942_abnormal_urinary_system0.72298002
80MP0005394_taste/olfaction_phenotype0.72076847
81MP0005499_abnormal_olfactory_system0.72076847
82MP0008058_abnormal_DNA_repair0.71610086
83MP0000534_abnormal_ureter_morphology0.68018398
84MP0006292_abnormal_olfactory_placode0.64479693
85MP0005636_abnormal_mineral_homeostasis0.64172032
86MP0002928_abnormal_bile_duct0.63558221
87MP0005645_abnormal_hypothalamus_physiol0.62977055
88MP0002272_abnormal_nervous_system0.61633397
89MP0002102_abnormal_ear_morphology0.60332157
90MP0003635_abnormal_synaptic_transmissio0.60095746
91MP0002572_abnormal_emotion/affect_behav0.59051502
92MP0001764_abnormal_homeostasis0.58822477
93MP0005195_abnormal_posterior_eye0.58553574
94MP0003787_abnormal_imprinting0.57931959
95MP0002063_abnormal_learning/memory/cond0.57257627
96MP0004742_abnormal_vestibular_system0.56837135
97MP0004811_abnormal_neuron_physiology0.56240746
98MP0003115_abnormal_respiratory_system0.56221578
99MP0005646_abnormal_pituitary_gland0.55856138
100MP0004270_analgesia0.55703341
101MP0005391_vision/eye_phenotype0.55666712
102MP0002752_abnormal_somatic_nervous0.55507564
103MP0008569_lethality_at_weaning0.53820390
104MP0008995_early_reproductive_senescence0.51766363
105MP0002557_abnormal_social/conspecific_i0.51214142
106MP0004133_heterotaxia0.50678766
107MP0002229_neurodegeneration0.49626712
108MP0004036_abnormal_muscle_relaxation0.49491120
109MP0003329_amyloid_beta_deposits0.48766024
110MP0005423_abnormal_somatic_nervous0.47836324
111MP0001486_abnormal_startle_reflex0.47656390
112MP0002909_abnormal_adrenal_gland0.47176068
113MP0002734_abnormal_mechanical_nocicepti0.46855088
114MP0002152_abnormal_brain_morphology0.46797779
115MP0002882_abnormal_neuron_morphology0.46413962
116MP0001293_anophthalmia0.45109789
117MP0001270_distended_abdomen0.44232343
118MP0000631_abnormal_neuroendocrine_gland0.43049356
119MP0003861_abnormal_nervous_system0.41626155
120MP0002064_seizures0.41204000
121MP0002735_abnormal_chemical_nociception0.40907978
122MP0001529_abnormal_vocalization0.40569286
123MP0002184_abnormal_innervation0.40259886
124MP0004043_abnormal_pH_regulation0.40138568
125MP0004885_abnormal_endolymph0.39980864
126MP0000026_abnormal_inner_ear0.38294643
127MP0003633_abnormal_nervous_system0.37706614
128MP0009697_abnormal_copulation0.37601439
129MP0006036_abnormal_mitochondrial_physio0.37313765
130MP0002693_abnormal_pancreas_physiology0.36780979
131MP0000462_abnormal_digestive_system0.36690055
132MP0003699_abnormal_female_reproductive0.36556168
133MP0000049_abnormal_middle_ear0.36035388
134MP0002067_abnormal_sensory_capabilities0.35859516
135MP0003879_abnormal_hair_cell0.34930061
136MP0000566_synostosis0.34542104
137MP0006276_abnormal_autonomic_nervous0.34500247
138MP0002876_abnormal_thyroid_physiology0.34300360
139MP0009745_abnormal_behavioral_response0.32825839
140MP0001963_abnormal_hearing_physiology0.32403543
141MP0003948_abnormal_gas_homeostasis0.31730073
142MP0002638_abnormal_pupillary_reflex0.31601893
143MP0001986_abnormal_taste_sensitivity0.31017699
144MP0002269_muscular_atrophy0.30567355
145MP0003878_abnormal_ear_physiology0.30042016
146MP0005377_hearing/vestibular/ear_phenot0.30042016

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.10962884
2Abnormal respiratory epithelium morphology (HP:0012253)8.94809399
3Abnormal respiratory motile cilium morphology (HP:0005938)8.94809399
4Abnormal ciliary motility (HP:0012262)7.18978196
5Rhinitis (HP:0012384)7.14745222
6Chronic bronchitis (HP:0004469)7.08155816
7Infertility (HP:0000789)6.56104530
8Nasal polyposis (HP:0100582)5.45246174
9Abnormality of the labia minora (HP:0012880)4.89880822
10Male infertility (HP:0003251)4.87265607
11Abnormality of the nasal mucosa (HP:0000433)4.34759883
12Bronchiectasis (HP:0002110)4.10614688
13Nephronophthisis (HP:0000090)4.02850141
14Bronchitis (HP:0012387)4.02059059
15Reticulocytopenia (HP:0001896)3.62890770
16Medial flaring of the eyebrow (HP:0010747)3.21081315
17Stenosis of the external auditory canal (HP:0000402)3.19750809
18Tubulointerstitial nephritis (HP:0001970)3.18262618
19Abnormality of midbrain morphology (HP:0002418)3.16386545
20Molar tooth sign on MRI (HP:0002419)3.16386545
21Abnormal spermatogenesis (HP:0008669)3.13566397
22Abnormality of the renal medulla (HP:0100957)3.05077488
23Acute necrotizing encephalopathy (HP:0006965)2.99482290
24Recurrent otitis media (HP:0000403)2.93190439
25Chromsome breakage (HP:0040012)2.88911545
26Abnormal mitochondria in muscle tissue (HP:0008316)2.88209086
27Recurrent sinusitis (HP:0011108)2.83294791
28Oligodactyly (hands) (HP:0001180)2.78984759
29Decreased central vision (HP:0007663)2.67960650
30Abnormality of cells of the erythroid lineage (HP:0012130)2.65524279
31Myokymia (HP:0002411)2.61022534
32Tubulointerstitial abnormality (HP:0001969)2.50149381
33Poor suck (HP:0002033)2.49774386
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49642743
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49642743
36Mitochondrial inheritance (HP:0001427)2.49151192
37Cholecystitis (HP:0001082)2.48478633
38Abnormal gallbladder physiology (HP:0012438)2.48478633
39Choroideremia (HP:0001139)2.47166028
40Hepatocellular necrosis (HP:0001404)2.42256564
41Acute encephalopathy (HP:0006846)2.41510049
42Tubular atrophy (HP:0000092)2.40424404
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40357042
44Dyschromatopsia (HP:0007641)2.37824210
45Hepatic necrosis (HP:0002605)2.36895341
46Short tibia (HP:0005736)2.36311251
47Oligomenorrhea (HP:0000876)2.29060737
48Congenital malformation of the right heart (HP:0011723)2.28826320
49Double outlet right ventricle (HP:0001719)2.28826320
50Increased CSF lactate (HP:0002490)2.27757356
51Macrocytic anemia (HP:0001972)2.27733412
52Progressive macrocephaly (HP:0004481)2.27521509
53Absent thumb (HP:0009777)2.26546339
54Septo-optic dysplasia (HP:0100842)2.26230376
55Triphalangeal thumb (HP:0001199)2.26107147
56Oligodactyly (HP:0012165)2.24184177
57Polyphagia (HP:0002591)2.23707750
58Gait imbalance (HP:0002141)2.21305580
59Horseshoe kidney (HP:0000085)2.20583011
60Meckel diverticulum (HP:0002245)2.20525183
61Birth length less than 3rd percentile (HP:0003561)2.20425619
62Congenital primary aphakia (HP:0007707)2.16771516
63Aplasia/Hypoplasia of the lens (HP:0008063)2.16203857
64Testicular atrophy (HP:0000029)2.16119718
65Abnormal biliary tract physiology (HP:0012439)2.15037958
66Bile duct proliferation (HP:0001408)2.15037958
67Abnormality of the ileum (HP:0001549)2.12978708
68Hypokinesia (HP:0002375)2.11274811
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.07449496
70Supernumerary spleens (HP:0009799)2.06900989
71J-shaped sella turcica (HP:0002680)2.05435311
72True hermaphroditism (HP:0010459)2.02331708
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01493284
74Abnormality of the aortic arch (HP:0012303)2.01385548
75Absent/shortened dynein arms (HP:0200106)12.4067284
76Dynein arm defect of respiratory motile cilia (HP:0012255)12.4067284
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2103574
78Nephrogenic diabetes insipidus (HP:0009806)1.99552368
79Abnormality of the preputium (HP:0100587)1.98148124
80Recurrent bronchitis (HP:0002837)1.97994553
81Cerebral edema (HP:0002181)1.97640981
82Failure to thrive in infancy (HP:0001531)1.96363156
83Maternal diabetes (HP:0009800)1.95295105
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.94499968
85Colon cancer (HP:0003003)1.93959748
86Tubulointerstitial fibrosis (HP:0005576)1.93906930
87Azoospermia (HP:0000027)1.92743715
88Impulsivity (HP:0100710)1.89839573
89Pancreatic fibrosis (HP:0100732)1.88929795
90Esotropia (HP:0000565)1.88860687
91Absent epiphyses (HP:0010577)1.88725132
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88725132
93Postaxial foot polydactyly (HP:0001830)1.86767347
94Abnormal hair whorl (HP:0010721)1.84604366
95Vaginal atresia (HP:0000148)1.84206851
96Absent septum pellucidum (HP:0001331)1.84045384
97Polydipsia (HP:0001959)1.83879690
98Abnormal drinking behavior (HP:0030082)1.83879690
99Congenital hepatic fibrosis (HP:0002612)1.83330466
100Abnormality of the anterior horn cell (HP:0006802)1.82649962
101Degeneration of anterior horn cells (HP:0002398)1.82649962
102Hypoplastic female external genitalia (HP:0012815)1.82133100
103Respiratory failure (HP:0002878)1.81601100
104Sclerocornea (HP:0000647)1.81157536
105Abnormality of the labia (HP:0000058)1.80604997
106Aplasia involving forearm bones (HP:0009822)1.79789065
107Absent forearm bone (HP:0003953)1.79789065
108Genital tract atresia (HP:0001827)1.79373328
109Constricted visual fields (HP:0001133)1.79365180
110Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79305922
111Small intestinal stenosis (HP:0012848)1.78142594
112Duodenal stenosis (HP:0100867)1.78142594
113Labial hypoplasia (HP:0000066)1.77814464
114Abnormality of chromosome stability (HP:0003220)1.76815248
115Hyperglycinuria (HP:0003108)1.75837878
116Ectopic kidney (HP:0000086)1.75587298
117Neurofibrillary tangles (HP:0002185)1.75331995
118Exotropia (HP:0000577)1.74740557
119Absent radius (HP:0003974)1.74698127
120Stage 5 chronic kidney disease (HP:0003774)1.74629427
121Increased serum lactate (HP:0002151)1.74383579
122Abnormality of abdominal situs (HP:0011620)1.74276689
123Abdominal situs inversus (HP:0003363)1.74276689
124Abnormality of glycine metabolism (HP:0010895)1.73458064
125Abnormality of serine family amino acid metabolism (HP:0010894)1.73458064
126Lactic acidosis (HP:0003128)1.72200933
127Postaxial hand polydactyly (HP:0001162)1.71791672
128Gonadotropin excess (HP:0000837)1.71296209
129Attenuation of retinal blood vessels (HP:0007843)1.71075822
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70965707
131Sensory axonal neuropathy (HP:0003390)1.70547144
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70355091
133Abnormality of renal excretion (HP:0011036)1.70297797
134Type 2 muscle fiber atrophy (HP:0003554)1.70260911
135Cystic liver disease (HP:0006706)1.70153223
136Optic nerve hypoplasia (HP:0000609)1.69691568
137Hypoplastic pelvis (HP:0008839)1.69567764
138Hypoplastic left heart (HP:0004383)1.69489935
139Cerebral hypomyelination (HP:0006808)1.68365267
140Abnormality of the phalanges of the hallux (HP:0010057)1.68003905
141Hyperglycinemia (HP:0002154)1.67906415
142Preaxial hand polydactyly (HP:0001177)1.67608374
143Abnormal ventriculo-arterial connection (HP:0011563)1.66811538
144Transposition of the great arteries (HP:0001669)1.66811538
145Abnormality of DNA repair (HP:0003254)1.64294421
146Asymmetric septal hypertrophy (HP:0001670)1.64169255
147Retinal dysplasia (HP:0007973)1.61214618
148Type I transferrin isoform profile (HP:0003642)1.60917388
149Poor coordination (HP:0002370)1.60636890
150Hypoplasia of the radius (HP:0002984)1.60580865
151Abnormality of dentin (HP:0010299)1.60416209
152Inability to walk (HP:0002540)1.60076820
153Abnormality of the duodenum (HP:0002246)1.59898625
154Taurodontia (HP:0000679)1.59547741
155Abnormality of permanent molar morphology (HP:0011071)1.59547741
156Abnormality of the dental root (HP:0006486)1.59547741
157CNS hypomyelination (HP:0003429)1.59467404
158Abnormality of macular pigmentation (HP:0008002)1.57898005
159Oculomotor apraxia (HP:0000657)1.57292560
160Fatigable weakness (HP:0003473)1.54214739
161Abnormality of the neuromuscular junction (HP:0003398)1.54214739
162Abnormality of the dental pulp (HP:0006479)1.51452498
163Easy fatigability (HP:0003388)1.50913772
164Supranuclear gaze palsy (HP:0000605)1.50376533
165Abnormality of the renal cortex (HP:0011035)1.50128030
166Pancreatic cysts (HP:0001737)1.49961504
167Aplasia/Hypoplasia affecting the retina (HP:0008061)1.48415211
168Abnormality of molar (HP:0011077)1.47058685
169Abnormality of molar morphology (HP:0011070)1.47058685
170Broad distal phalanx of finger (HP:0009836)1.46496858
171Exercise-induced myalgia (HP:0003738)1.45022284
172Abnormal urine output (HP:0012590)1.44775602
173Chronic sinusitis (HP:0011109)1.43435743
174Severe visual impairment (HP:0001141)1.40001954
175Aplasia/Hypoplasia of the tongue (HP:0010295)1.39405797
176Aplasia/Hypoplasia of the macula (HP:0008059)1.37693716
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.36990988
178Occipital encephalocele (HP:0002085)1.36946634
179Facial cleft (HP:0002006)1.34961519
180Renal dysplasia (HP:0000110)1.34943468
181Muscle fiber atrophy (HP:0100295)1.34638892
182Hemorrhage of the eye (HP:0011885)1.34273911
183Aplasia/Hypoplasia of the brainstem (HP:0007362)1.33072272
184Hypoplasia of the brainstem (HP:0002365)1.33072272
185Myoglobinuria (HP:0002913)1.30100673
186Bulbar palsy (HP:0001283)1.29893250
187Abnormal connection of the cardiac segments (HP:0011545)1.29437135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.16484557
2PDK48.16484557
3TESK16.19509530
4PDK25.12236682
5PRKD34.52800054
6ICK4.37593793
7MAP4K23.62913737
8BUB13.56300930
9PBK2.94752323
10CDC72.84566589
11PLK42.79409754
12VRK22.76478627
13WNK42.17711768
14SRPK12.10347355
15CDK192.08850886
16ZAK1.95130188
17STK161.94690490
18STK391.89410898
19TSSK61.85820968
20STK381.85114098
21DYRK1B1.83968918
22PTK2B1.79212747
23ARAF1.70608581
24PLK11.62018610
25NEK11.60900643
26MAPK151.58101360
27BCKDK1.58044840
28VRK11.54571789
29TRIM281.49394583
30MAP3K91.48643002
31AURKA1.44592328
32PRKCI1.42590135
33DYRK31.41262504
34EPHA41.37321709
35MAP3K121.35882880
36PLK31.34890426
37EIF2AK11.33516766
38AURKB1.31084176
39NME11.27397763
40TESK21.27297847
41PDK11.18504434
42IRAK11.17300733
43TAOK11.15457830
44NME21.09133855
45LRRK21.04595318
46CDK71.03346801
47CSNK1G31.01811393
48CSNK1G11.01049006
49NEK21.00294652
50PLK20.98225733
51TAF10.98100907
52PINK10.97828624
53IRAK20.93589066
54WEE10.92572948
55CSNK1G20.91110752
56MAP3K110.89627609
57AKT20.87588540
58PASK0.85945062
59RIPK40.85497560
60NUAK10.82726900
61LMTK20.82094270
62NTRK20.77960125
63MST40.76230610
64STK38L0.75035400
65PDPK10.74555334
66PNCK0.74132186
67WNK10.73992996
68DAPK30.73638853
69MUSK0.68792688
70PRKCG0.67534902
71CSNK1A1L0.67368499
72MAP2K60.66332470
73TLK10.63499239
74MAP2K70.58520765
75SMG10.58142899
76MAPKAPK50.56718637
77MKNK20.56710188
78CSNK1E0.56067651
79DAPK10.55534477
80CDK10.52970627
81CHEK20.51877201
82CDK20.50645918
83CSNK2A20.49309507
84OXSR10.48211023
85MAP3K40.47492547
86CAMK1G0.46788735
87MET0.45153764
88CDK80.44284297
89EEF2K0.44188437
90CCNB10.43427305
91MAP2K40.43134772
92TYRO30.42956448
93MARK10.41628761
94MAP3K80.41387946
95TNIK0.40049993
96INSRR0.39444731
97KSR10.39189056
98CDK30.38479161
99CSNK1A10.37267926
100PRKCZ0.37098758
101BRSK20.36779156
102MARK20.36318247
103ERBB30.34755995
104CAMK2G0.34724057
105CAMK10.34577434
106BMPR1B0.33834253
107RAF10.33554647
108WNK30.28426192
109GRK10.28355882
110PRKAA10.28235713
111NTRK30.28182249
112BMPR20.28163844
113BRAF0.27879814
114MAP3K100.26423908
115NEK60.25472160
116RPS6KB10.24987886
117CDK150.24494600
118ADRBK20.24494428
119CDK180.23584500
120PAK10.23191579
121PRKCQ0.22003165
122CASK0.21560990
123CDK140.21525357
124PKN10.20961788
125PIK3CG0.19860281
126CAMK2A0.19200873
127PRKG10.19077495
128SGK4940.19053381
129SGK2230.19053381
130STK30.18938212
131YES10.18935749
132MAPK130.18791230
133CDK11A0.18763498
134DYRK1A0.18515591
135CHEK10.16205631
136RPS6KA20.16204309
137UHMK10.14834214
138PRKG20.13812267
139MINK10.12284904
140PRKACG0.11542094
141PRKCA0.11274444
142PRKCD0.10321752
143GSK3B0.10212567
144PRKCB0.10014338
145MAP3K50.09971058
146BRSK10.09831814
147TNK20.09702680
148ZAP700.09557439
149TTK0.09527630
150PRKACA0.09321424
151RPS6KA10.08389582
152CAMKK10.07719531
153ATM0.07441850
154AKT30.07049786
155ATR0.06638382
156CSNK2A10.06549424
157DYRK20.06467058
158SGK20.05840665
159PAK20.05105358
160PHKG10.04299056
161PHKG20.04299056
162CDK50.04025184
163RPS6KA30.02975399
164PAK60.02695507

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.08869104
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.00468828
3Ribosome_Homo sapiens_hsa030103.90180790
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.36010125
5Linoleic acid metabolism_Homo sapiens_hsa005913.27412442
6Pyruvate metabolism_Homo sapiens_hsa006202.99415803
7Oxidative phosphorylation_Homo sapiens_hsa001902.66482100
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65595607
9Parkinsons disease_Homo sapiens_hsa050122.52673818
10Vitamin B6 metabolism_Homo sapiens_hsa007502.45889789
11DNA replication_Homo sapiens_hsa030302.44087536
12Mismatch repair_Homo sapiens_hsa034302.42664013
13Sulfur relay system_Homo sapiens_hsa041222.41169594
14Glucagon signaling pathway_Homo sapiens_hsa049222.37251519
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.35238062
16RNA polymerase_Homo sapiens_hsa030202.34877859
17Basal transcription factors_Homo sapiens_hsa030222.21801164
18Proteasome_Homo sapiens_hsa030502.15469851
19Homologous recombination_Homo sapiens_hsa034402.15335204
20Base excision repair_Homo sapiens_hsa034102.08949332
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07323344
22Propanoate metabolism_Homo sapiens_hsa006401.96395975
23Folate biosynthesis_Homo sapiens_hsa007901.90842946
24RNA transport_Homo sapiens_hsa030131.90792622
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85121997
26Non-homologous end-joining_Homo sapiens_hsa034501.83064975
27Collecting duct acid secretion_Homo sapiens_hsa049661.81869390
28Amphetamine addiction_Homo sapiens_hsa050311.80574044
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79672529
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.77524310
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76828742
32Mineral absorption_Homo sapiens_hsa049781.76696624
33Ether lipid metabolism_Homo sapiens_hsa005651.74239139
34Nucleotide excision repair_Homo sapiens_hsa034201.70862783
35Insulin secretion_Homo sapiens_hsa049111.65762160
36Fructose and mannose metabolism_Homo sapiens_hsa000511.63738642
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63162478
38Synaptic vesicle cycle_Homo sapiens_hsa047211.61892370
39RNA degradation_Homo sapiens_hsa030181.60586044
40Spliceosome_Homo sapiens_hsa030401.59882172
41Cardiac muscle contraction_Homo sapiens_hsa042601.59848864
42Steroid biosynthesis_Homo sapiens_hsa001001.59469417
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58334952
44Cell cycle_Homo sapiens_hsa041101.56995109
45Glycerolipid metabolism_Homo sapiens_hsa005611.55177933
46Alzheimers disease_Homo sapiens_hsa050101.49166063
47Pyrimidine metabolism_Homo sapiens_hsa002401.47878424
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47300480
49Fat digestion and absorption_Homo sapiens_hsa049751.46255397
50Selenocompound metabolism_Homo sapiens_hsa004501.42457051
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38771461
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35526112
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.35426345
54Fatty acid elongation_Homo sapiens_hsa000621.32661526
55PPAR signaling pathway_Homo sapiens_hsa033201.31161060
56Protein export_Homo sapiens_hsa030601.31160010
57Fatty acid metabolism_Homo sapiens_hsa012121.27990798
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26582736
59Arginine and proline metabolism_Homo sapiens_hsa003301.25231453
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23495435
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21463942
62Glutathione metabolism_Homo sapiens_hsa004801.17767434
63Fatty acid degradation_Homo sapiens_hsa000711.15485100
64Renin secretion_Homo sapiens_hsa049241.14923744
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13101564
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10797485
67Arachidonic acid metabolism_Homo sapiens_hsa005901.10221168
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10208035
69Oocyte meiosis_Homo sapiens_hsa041141.06822861
70Pentose phosphate pathway_Homo sapiens_hsa000301.05862071
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05529805
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04937969
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03096553
74Hedgehog signaling pathway_Homo sapiens_hsa043401.00192602
75Taste transduction_Homo sapiens_hsa047420.99280500
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98656089
77Circadian entrainment_Homo sapiens_hsa047130.97859823
78Purine metabolism_Homo sapiens_hsa002300.97605616
79Nicotine addiction_Homo sapiens_hsa050330.96391635
80Carbon metabolism_Homo sapiens_hsa012000.95655813
81Chemical carcinogenesis_Homo sapiens_hsa052040.94825932
82Huntingtons disease_Homo sapiens_hsa050160.93321465
83Phototransduction_Homo sapiens_hsa047440.91987601
84One carbon pool by folate_Homo sapiens_hsa006700.90836622
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89237204
86Long-term potentiation_Homo sapiens_hsa047200.85182898
87Salivary secretion_Homo sapiens_hsa049700.81009918
88Thyroid hormone synthesis_Homo sapiens_hsa049180.80189064
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78473507
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74133913
91Pancreatic secretion_Homo sapiens_hsa049720.74099242
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73261564
93Fanconi anemia pathway_Homo sapiens_hsa034600.73121925
94Regulation of autophagy_Homo sapiens_hsa041400.72975477
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.72302394
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72123453
97Inositol phosphate metabolism_Homo sapiens_hsa005620.69783511
98Vibrio cholerae infection_Homo sapiens_hsa051100.69446848
99Gastric acid secretion_Homo sapiens_hsa049710.68703906
100Olfactory transduction_Homo sapiens_hsa047400.68686940
101Cocaine addiction_Homo sapiens_hsa050300.68264174
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67998682
103Calcium signaling pathway_Homo sapiens_hsa040200.67039128
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66855451
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66530030
106Alcoholism_Homo sapiens_hsa050340.65349006
107Bile secretion_Homo sapiens_hsa049760.65191642
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63406901
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61870823
110Estrogen signaling pathway_Homo sapiens_hsa049150.61154533
111Caffeine metabolism_Homo sapiens_hsa002320.61036303
112p53 signaling pathway_Homo sapiens_hsa041150.60421427
113ABC transporters_Homo sapiens_hsa020100.59598111
114Sulfur metabolism_Homo sapiens_hsa009200.57785724
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.57547384
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56723718
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.56545531
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.54324464
119Nitrogen metabolism_Homo sapiens_hsa009100.54112239
120Dopaminergic synapse_Homo sapiens_hsa047280.53708742
121Morphine addiction_Homo sapiens_hsa050320.53170990
122Glutamatergic synapse_Homo sapiens_hsa047240.52153234
123Biosynthesis of amino acids_Homo sapiens_hsa012300.50130813
124Circadian rhythm_Homo sapiens_hsa047100.50004141
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.49767854
126Basal cell carcinoma_Homo sapiens_hsa052170.48831060
127cAMP signaling pathway_Homo sapiens_hsa040240.48601903
128Metabolic pathways_Homo sapiens_hsa011000.47941431
129Phenylalanine metabolism_Homo sapiens_hsa003600.47341098
130Dorso-ventral axis formation_Homo sapiens_hsa043200.46319688
131Systemic lupus erythematosus_Homo sapiens_hsa053220.46096849
132Arginine biosynthesis_Homo sapiens_hsa002200.45576519
133Peroxisome_Homo sapiens_hsa041460.45418958
134Hippo signaling pathway_Homo sapiens_hsa043900.44540481
135Butanoate metabolism_Homo sapiens_hsa006500.44342747
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43533721
137Antigen processing and presentation_Homo sapiens_hsa046120.41504496
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41264711
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40091379
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39960569
141Protein digestion and absorption_Homo sapiens_hsa049740.39808049
142mRNA surveillance pathway_Homo sapiens_hsa030150.39723026
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.39090979
144Renin-angiotensin system_Homo sapiens_hsa046140.36681567
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36453631
146beta-Alanine metabolism_Homo sapiens_hsa004100.35087559
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34879470
148Wnt signaling pathway_Homo sapiens_hsa043100.33900447
149Tight junction_Homo sapiens_hsa045300.32888916
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32522820
151Endocytosis_Homo sapiens_hsa041440.31611491
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30209419
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30125954
154TGF-beta signaling pathway_Homo sapiens_hsa043500.29533024
155Legionellosis_Homo sapiens_hsa051340.28586045
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27863393
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.27563377
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27265115
159Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24790651
160GABAergic synapse_Homo sapiens_hsa047270.24775031
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24377696

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