FAM71E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)9.75954251
2spermatid development (GO:0007286)9.69698185
3response to pheromone (GO:0019236)9.66827407
4reproduction (GO:0000003)9.60382763
5motile cilium assembly (GO:0044458)9.56839474
6cilium movement (GO:0003341)8.51887336
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.05016119
8single fertilization (GO:0007338)7.78692403
9piRNA metabolic process (GO:0034587)7.73522362
10sperm capacitation (GO:0048240)7.49578441
11male meiosis (GO:0007140)7.39989101
12synaptonemal complex organization (GO:0070193)7.13410633
13negative regulation of inclusion body assembly (GO:0090084)6.87043341
14synaptonemal complex assembly (GO:0007130)6.75264575
15rRNA methylation (GO:0031167)6.71004680
16fertilization (GO:0009566)6.55466069
17spermatogenesis (GO:0007283)6.45817602
18male gamete generation (GO:0048232)6.43449689
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.39770156
20microtubule depolymerization (GO:0007019)6.37158064
21organic cation transport (GO:0015695)6.20462127
22protein targeting to Golgi (GO:0000042)5.93881215
23phosphatidylethanolamine metabolic process (GO:0046337)5.91213582
24gamete generation (GO:0007276)5.91089735
25cellular ketone body metabolic process (GO:0046950)5.86503123
26regulation of microtubule-based movement (GO:0060632)5.80260843
27establishment of protein localization to Golgi (GO:0072600)5.73608786
28ventricular system development (GO:0021591)5.70602009
29regulation of inclusion body assembly (GO:0090083)5.68506471
30rRNA modification (GO:0000154)5.61994728
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.53320588
32germ cell development (GO:0007281)5.43685810
33calcium ion-dependent exocytosis (GO:0017156)5.43675096
34male meiosis I (GO:0007141)5.40039044
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.38407449
36regulation of Rab GTPase activity (GO:0032313)5.33734381
37positive regulation of Rab GTPase activity (GO:0032851)5.33734381
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32915629
39ketone body metabolic process (GO:1902224)5.17332050
40centriole replication (GO:0007099)5.06953074
41cell recognition (GO:0008037)4.90083005
42DNA methylation involved in gamete generation (GO:0043046)4.84423716
43regulation of transcription involved in cell fate commitment (GO:0060850)4.83028714
44chromatin silencing (GO:0006342)4.82906115
45left/right pattern formation (GO:0060972)4.78107327
46multicellular organismal reproductive process (GO:0048609)4.68267446
47microtubule severing (GO:0051013)4.66782130
48chromosome organization involved in meiosis (GO:0070192)4.61462044
49glycerol ether metabolic process (GO:0006662)4.57277181
50meiotic nuclear division (GO:0007126)4.39597800
51seminiferous tubule development (GO:0072520)4.38911594
52meiosis I (GO:0007127)4.31992672
53protein localization to Golgi apparatus (GO:0034067)4.25093857
54ether metabolic process (GO:0018904)4.22308917
55chromosome condensation (GO:0030261)4.14368084
56coenzyme catabolic process (GO:0009109)4.12417996
57spermatid nucleus differentiation (GO:0007289)4.09590067
58DNA packaging (GO:0006323)3.97416024
59chaperone-mediated protein complex assembly (GO:0051131)3.86916459
60negative regulation of Rho protein signal transduction (GO:0035024)3.83186641
61genitalia morphogenesis (GO:0035112)3.81730996
62response to acidic pH (GO:0010447)3.81382579
63protein polyglutamylation (GO:0018095)3.76953665
64multicellular organismal development (GO:0007275)3.75283116
65monoubiquitinated protein deubiquitination (GO:0035520)3.71754670
66peptidyl-threonine dephosphorylation (GO:0035970)3.60015198
67meiotic cell cycle (GO:0051321)3.56452118
68multicellular organismal movement (GO:0050879)3.55750751
69musculoskeletal movement (GO:0050881)3.55750751
70protein localization to cilium (GO:0061512)3.55156629
71cellular response to pH (GO:0071467)3.53045323
72protein refolding (GO:0042026)3.48499238
73cerebral cortex neuron differentiation (GO:0021895)3.47926353
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.47553121
75polyamine biosynthetic process (GO:0006596)3.46028850
76nucleosome disassembly (GO:0006337)3.44349942
77protein-DNA complex disassembly (GO:0032986)3.44349942
78negative regulation of gene expression, epigenetic (GO:0045814)3.30118635
79microtubule polymerization or depolymerization (GO:0031109)3.26999403
80carnitine transport (GO:0015879)3.23717535
81amino-acid betaine transport (GO:0015838)3.23717535
82regulation of spindle checkpoint (GO:0090231)3.23454547
83histone H3-K9 demethylation (GO:0033169)3.22831835
84regulation of T-helper 2 cell differentiation (GO:0045628)3.22214914
85membrane protein intracellular domain proteolysis (GO:0031293)3.22098951
86regulation of interleukin-13 production (GO:0032656)3.21683762
87glycolytic process (GO:0006096)3.19595361
88protein depolymerization (GO:0051261)3.19502792
89mesenchymal cell differentiation involved in kidney development (GO:0072161)3.19182150
90mesenchymal cell differentiation involved in renal system development (GO:2001012)3.19182150
91single strand break repair (GO:0000012)3.16794130
92cranial nerve morphogenesis (GO:0021602)3.13964290
93sexual reproduction (GO:0019953)3.13279481
94homeostasis of number of cells within a tissue (GO:0048873)3.08395870
95regulation of somitogenesis (GO:0014807)3.08140571
96carnitine transmembrane transport (GO:1902603)3.07250429
97microtubule-based movement (GO:0007018)3.07014285
98cell differentiation involved in metanephros development (GO:0072202)3.06360499
99negative regulation of organelle assembly (GO:1902116)3.03419365
100nucleus organization (GO:0006997)3.02132326
101cilium organization (GO:0044782)3.00853254
102mitotic sister chromatid cohesion (GO:0007064)2.99593032
103nucleoside diphosphate phosphorylation (GO:0006165)2.97619859
104DNA conformation change (GO:0071103)2.96223819
105polyol catabolic process (GO:0046174)2.95222708
106NAD biosynthetic process (GO:0009435)2.94046047
107intraciliary transport (GO:0042073)2.93901898
108RNA localization (GO:0006403)2.91199680
109axoneme assembly (GO:0035082)2.90360159
110alditol metabolic process (GO:0019400)2.89256545
111cilium assembly (GO:0042384)2.88174876
112glomerular visceral epithelial cell development (GO:0072015)2.87061664
113gene silencing by RNA (GO:0031047)2.86801983
114meiotic cell cycle process (GO:1903046)2.85354869
115negative regulation of histone methylation (GO:0031061)2.84120531
116lactate metabolic process (GO:0006089)2.82933961
117glomerular epithelial cell development (GO:0072310)2.82504473
118protein K11-linked deubiquitination (GO:0035871)2.80869646
119nuclear pore complex assembly (GO:0051292)2.80450886
120tooth mineralization (GO:0034505)2.79851996
121negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.78132554
122regulation of phosphoprotein phosphatase activity (GO:0043666)2.76138278
123cilium morphogenesis (GO:0060271)2.75201961
124mitotic G1 DNA damage checkpoint (GO:0031571)2.74128277
125cellular component assembly involved in morphogenesis (GO:0010927)2.73881770
126synapsis (GO:0007129)2.71670646
127RNA destabilization (GO:0050779)2.71416258
128peptidyl-glutamic acid modification (GO:0018200)2.68107892
129negative regulation of skeletal muscle tissue development (GO:0048642)2.62088939
130regulation of protein kinase C signaling (GO:0090036)2.61331273
131GTP biosynthetic process (GO:0006183)2.58852758
132regulation of meiosis I (GO:0060631)2.58620761
133regulation of cilium assembly (GO:1902017)2.56918920
134regulation of centriole replication (GO:0046599)2.56263972
135centriole assembly (GO:0098534)2.55520395
136interferon-gamma secretion (GO:0072643)2.54818509
137fusion of sperm to egg plasma membrane (GO:0007342)14.0201497
138sperm motility (GO:0030317)13.9447693
139acrosome reaction (GO:0007340)11.9838613
140cilium or flagellum-dependent cell motility (GO:0001539)11.7230773
141multicellular organism reproduction (GO:0032504)11.4526941
142sperm-egg recognition (GO:0035036)11.3470453
143cell wall macromolecule metabolic process (GO:0044036)10.8713471
144cell wall macromolecule catabolic process (GO:0016998)10.8713471
145plasma membrane fusion (GO:0045026)10.6891880
146acrosome assembly (GO:0001675)10.5132245
147axonemal dynein complex assembly (GO:0070286)10.4888096
148epithelial cilium movement (GO:0003351)10.2614929
149cell-cell recognition (GO:0009988)10.1508990
150binding of sperm to zona pellucida (GO:0007339)10.1178231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.67467310
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.85841024
3EZH2_22144423_ChIP-Seq_EOC_Human4.50446783
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.12035245
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.85098687
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30888269
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.27915759
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91038002
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86087236
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53105004
11VDR_22108803_ChIP-Seq_LS180_Human2.46119077
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.30953040
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15203349
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10083224
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07305994
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.99806492
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97851309
18DROSHA_22980978_ChIP-Seq_HELA_Human1.92393384
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.91842801
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.90000208
21RAC3_21632823_ChIP-Seq_H3396_Human1.89626425
22* ERA_21632823_ChIP-Seq_H3396_Human1.88773358
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88341730
24ZNF274_21170338_ChIP-Seq_K562_Hela1.86502960
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.81174746
26* CTCF_27219007_Chip-Seq_Bcells_Human1.77460408
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76165677
28BCL6_27268052_Chip-Seq_Bcells_Human1.75750580
29* NANOG_20526341_ChIP-Seq_ESCs_Human1.74079906
30SMC4_20622854_ChIP-Seq_HELA_Human1.70954809
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70938352
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70190372
33STAT1_17558387_ChIP-Seq_HELA_Human1.70009959
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.69785356
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.64751003
36BCOR_27268052_Chip-Seq_Bcells_Human1.63199531
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63022364
38P68_20966046_ChIP-Seq_HELA_Human1.62435672
39* E2F1_20622854_ChIP-Seq_HELA_Human1.62395582
40TAF2_19829295_ChIP-Seq_ESCs_Human1.61277710
41PHF8_20622854_ChIP-Seq_HELA_Human1.60374986
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.60158692
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59778702
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58212243
45LXR_22292898_ChIP-Seq_THP-1_Human1.57518894
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55910179
47CBP_20019798_ChIP-Seq_JUKART_Human1.55492999
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55492999
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54344566
50TP63_22573176_ChIP-Seq_HFKS_Human1.52857338
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52750147
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52624889
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.49734973
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49385432
55OCT4_20526341_ChIP-Seq_ESCs_Human1.49339757
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45904570
57ER_23166858_ChIP-Seq_MCF-7_Human1.45239799
58P300_27268052_Chip-Seq_Bcells_Human1.41806839
59TP53_18474530_ChIP-ChIP_U2OS_Human1.40002165
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.39657944
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39213761
62KDM2B_26808549_Chip-Seq_REH_Human1.38857945
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37148620
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36075883
65GATA3_21867929_ChIP-Seq_CD8_Mouse1.35594773
66AR_25329375_ChIP-Seq_VCAP_Human1.33884822
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.32585678
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32424218
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32388156
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31458095
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31149750
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.30545469
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30519161
74CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29662642
75P53_21459846_ChIP-Seq_SAOS-2_Human1.29404498
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.29003977
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28481384
78RBPJ_21746931_ChIP-Seq_IB4_Human1.27874482
79REST_21632747_ChIP-Seq_MESCs_Mouse1.27669369
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27066042
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.25839310
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.24725866
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.23633710
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22868457
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22858659
86ETV1_20927104_ChIP-Seq_GIST48_Human1.22684654
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21998378
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21921702
89TAF15_26573619_Chip-Seq_HEK293_Human1.21477916
90CEBPB_22108803_ChIP-Seq_LS180_Human1.20220649
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20123659
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.19302780
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.18928449
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18223584
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17991528
96SA1_27219007_Chip-Seq_Bcells_Human1.17729055
97GF1_26923725_Chip-Seq_HPCs_Mouse1.17064616
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16842057
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16756692
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16086569
101RUNX_20019798_ChIP-Seq_JUKART_Human1.15532889
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.15133497
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13912213
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13825936
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13825936
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.13566888
107RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13498111
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13481665
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.13473301
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12918118
111SMRT_27268052_Chip-Seq_Bcells_Human1.11585027
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10962173
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10908967
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10390562
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07721256
116P300_19829295_ChIP-Seq_ESCs_Human1.07618014
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07428117
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07356738
119ERG_20517297_ChIP-Seq_VCAP_Human1.07303154
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.03907627
121PHF8_20622853_ChIP-Seq_HELA_Human1.03834075
122* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03621994
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03618323
124* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03562704
125* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03428788
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.02698942
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.02047790
128CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01121894
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.00714654
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00432462
131* SPI1_26923725_Chip-Seq_HPCs_Mouse1.00392136
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.99317719
133RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99241579
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.98976925
135OCT1_27270436_Chip-Seq_PROSTATE_Human0.98439951
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.98341377
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97996351
138CTCF_20526341_ChIP-Seq_ESCs_Human0.97875861
139SOX2_19829295_ChIP-Seq_ESCs_Human0.97851989
140NANOG_19829295_ChIP-Seq_ESCs_Human0.97851989
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97798561
142RUNX2_22187159_ChIP-Seq_PCA_Human0.97703090
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97346401
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.96884373
145* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96156168
146KLF5_25053715_ChIP-Seq_YYC3_Human0.96099286
147NFYB_21822215_ChIP-Seq_K562_Human0.94869522
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.94463291
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.93917025
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93540363
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.93508452
152SOX2_21211035_ChIP-Seq_LN229_Human0.92071629
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91793759
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.91683273
155TBL1_22424771_ChIP-Seq_293T_Human0.91297433
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90990435
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.90748378
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90661280
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90344744
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90061762
161FUS_26573619_Chip-Seq_HEK293_Human0.89830317
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.89754838
163MYC_19829295_ChIP-Seq_ESCs_Human0.88682991
164P53_22387025_ChIP-Seq_ESCs_Mouse0.88609609
165RNF2_27304074_Chip-Seq_NSC_Mouse0.88528612
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88359632
167JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88147239
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87683425
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87458392
170FLI1_21867929_ChIP-Seq_CD8_Mouse0.86482753
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.86173471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06772077
2MP0001929_abnormal_gametogenesis5.42562423
3MP0008877_abnormal_DNA_methylation4.29802794
4MP0001348_abnormal_lacrimal_gland3.52023896
5MP0002210_abnormal_sex_determination3.42556881
6MP0002161_abnormal_fertility/fecundity3.33221053
7MP0005670_abnormal_white_adipose2.99258269
8MP0002653_abnormal_ependyma_morphology2.88708197
9MP0001145_abnormal_male_reproductive2.88374312
10MP0000678_abnormal_parathyroid_gland2.74721051
11MP0000653_abnormal_sex_gland2.49308568
12MP0002132_abnormal_respiratory_system2.40288371
13MP0003718_maternal_effect2.17508042
14MP0005410_abnormal_fertilization16.2052706
15MP0005623_abnormal_meninges_morphology1.97240346
16MP0002249_abnormal_larynx_morphology1.70142039
17MP0005379_endocrine/exocrine_gland_phen1.63894491
18MP0002160_abnormal_reproductive_system1.56481655
19MP0002282_abnormal_trachea_morphology1.55830295
20MP0009053_abnormal_anal_canal1.52714128
21MP0003646_muscle_fatigue1.51871967
22MP0004510_myositis1.48661592
23MP0002822_catalepsy1.45181831
24MP0005310_abnormal_salivary_gland1.38475926
25MP0001486_abnormal_startle_reflex1.36013465
26MP0001485_abnormal_pinna_reflex1.35710056
27MP0002735_abnormal_chemical_nociception1.27907234
28MP0004233_abnormal_muscle_weight1.24761732
29MP0001765_abnormal_ion_homeostasis1.21885689
30MP0004859_abnormal_synaptic_plasticity1.20437311
31MP0001968_abnormal_touch/_nociception1.15755478
32MP0005248_abnormal_Harderian_gland1.12382393
33MP0008995_early_reproductive_senescence1.12057920
34MP0002138_abnormal_hepatobiliary_system1.11982515
35MP0002127_abnormal_cardiovascular_syste1.11018029
36MP0001963_abnormal_hearing_physiology1.01665510
37MP0005377_hearing/vestibular/ear_phenot1.01226367
38MP0003878_abnormal_ear_physiology1.01226367
39MP0005395_other_phenotype1.00725183
40MP0000026_abnormal_inner_ear0.94863053
41MP0005647_abnormal_sex_gland0.94783637
42MP0009046_muscle_twitch0.93463175
43MP0001984_abnormal_olfaction0.89155230
44MP0000681_abnormal_thyroid_gland0.88741603
45MP0000955_abnormal_spinal_cord0.87520636
46MP0003115_abnormal_respiratory_system0.87227564
47MP0005451_abnormal_body_composition0.87162351
48MP0000049_abnormal_middle_ear0.84591560
49MP0008569_lethality_at_weaning0.82337042
50MP0001879_abnormal_lymphatic_vessel0.79300763
51MP0005389_reproductive_system_phenotype0.78761727
52MP0008058_abnormal_DNA_repair0.76013240
53MP0005666_abnormal_adipose_tissue0.73883402
54MP0002733_abnormal_thermal_nociception0.73771491
55MP0005083_abnormal_biliary_tract0.73019597
56MP0005367_renal/urinary_system_phenotyp0.70921581
57MP0000516_abnormal_urinary_system0.70921581
58MP0004085_abnormal_heartbeat0.70230855
59MP0002067_abnormal_sensory_capabilities0.68621239
60MP0000569_abnormal_digit_pigmentation0.64597029
61MP0001905_abnormal_dopamine_level0.64479392
62MP0005636_abnormal_mineral_homeostasis0.63528163
63MP0002557_abnormal_social/conspecific_i0.62633877
64MP0000003_abnormal_adipose_tissue0.62459754
65MP0005167_abnormal_blood-brain_barrier0.61863587
66MP0004484_altered_response_of0.61805461
67MP0001666_abnormal_nutrient_absorption0.61566173
68MP0003950_abnormal_plasma_membrane0.59132795
69MP0003329_amyloid_beta_deposits0.55878176
70MP0000358_abnormal_cell_content/0.55755473
71MP0003119_abnormal_digestive_system0.54682354
72MP0003011_delayed_dark_adaptation0.54659456
73MP0002572_abnormal_emotion/affect_behav0.53684495
74MP0009278_abnormal_bone_marrow0.53116249
75MP0001764_abnormal_homeostasis0.52056042
76MP0010094_abnormal_chromosome_stability0.51900290
77MP0001293_anophthalmia0.50916737
78MP0001324_abnormal_eye_pigmentation0.50814955
79MP0003699_abnormal_female_reproductive0.50587622
80MP0001970_abnormal_pain_threshold0.50003478
81MP0001440_abnormal_grooming_behavior0.48582173
82MP0002734_abnormal_mechanical_nocicepti0.48197608
83MP0005397_hematopoietic_system_phenotyp0.47498514
84MP0001545_abnormal_hematopoietic_system0.47498514
85MP0000249_abnormal_blood_vessel0.47215310
86MP0000470_abnormal_stomach_morphology0.46427982
87MP0003077_abnormal_cell_cycle0.46367921
88MP0002928_abnormal_bile_duct0.46165739
89MP0009697_abnormal_copulation0.46097456
90MP0003880_abnormal_central_pattern0.45861741
91MP0004036_abnormal_muscle_relaxation0.45830484
92MP0002234_abnormal_pharynx_morphology0.45445474
93MP0002272_abnormal_nervous_system0.45194170
94MP0002269_muscular_atrophy0.44035084
95MP0009115_abnormal_fat_cell0.43875599
96MP0000566_synostosis0.42080456
97MP0009745_abnormal_behavioral_response0.41885748
98MP0002971_abnormal_brown_adipose0.41756237
99MP0000613_abnormal_salivary_gland0.41072936
100MP0003091_abnormal_cell_migration0.40716483
101MP0003879_abnormal_hair_cell0.40683450
102MP0005535_abnormal_body_temperature0.40593539
103MP0006292_abnormal_olfactory_placode0.40240416
104MP0003137_abnormal_impulse_conducting0.39667086
105MP0003786_premature_aging0.39407639
106MP0008961_abnormal_basal_metabolism0.38907267
107MP0005253_abnormal_eye_physiology0.38406493
108MP0003936_abnormal_reproductive_system0.38107365
109MP0003111_abnormal_nucleus_morphology0.38030068
110MP0000534_abnormal_ureter_morphology0.37562140
111MP0001501_abnormal_sleep_pattern0.36551747
112MP0005551_abnormal_eye_electrophysiolog0.35100290
113MP0000467_abnormal_esophagus_morphology0.33722499
114MP0003942_abnormal_urinary_system0.33259509
115MP0003635_abnormal_synaptic_transmissio0.32945282
116MP0005391_vision/eye_phenotype0.32456489
117MP0005084_abnormal_gallbladder_morpholo0.32385202
118MP0002295_abnormal_pulmonary_circulatio0.32373861
119MP0001727_abnormal_embryo_implantation0.32165726
120MP0001270_distended_abdomen0.32130456
121MP0005375_adipose_tissue_phenotype0.31970237
122MP0000751_myopathy0.31252438
123MP0001119_abnormal_female_reproductive0.28382188
124MP0003633_abnormal_nervous_system0.27368200
125MP0002139_abnormal_hepatobiliary_system0.27264517
126MP0000604_amyloidosis0.27063388
127MP0008007_abnormal_cellular_replicative0.26776710
128MP0001730_embryonic_growth_arrest0.25919911
129MP0006036_abnormal_mitochondrial_physio0.25407881
130MP0004742_abnormal_vestibular_system0.24798219
131MP0004811_abnormal_neuron_physiology0.24530180
132MP0008057_abnormal_DNA_replication0.24127938
133MP0003948_abnormal_gas_homeostasis0.23691825
134MP0002102_abnormal_ear_morphology0.23512677
135MP0001661_extended_life_span0.23182993
136MP0003861_abnormal_nervous_system0.23120890
137MP0004133_heterotaxia0.21618628
138MP0002152_abnormal_brain_morphology0.21558906
139MP0004130_abnormal_muscle_cell0.21508622
140MP0004270_analgesia0.20802630
141MP0003631_nervous_system_phenotype0.20633894
142MP0002092_abnormal_eye_morphology0.20546991
143MP0003045_fibrosis0.20393152
144MP0002736_abnormal_nociception_after0.20275027
145MP0009672_abnormal_birth_weight0.19288671
146MP0003959_abnormal_lean_body0.18320539
147MP0004019_abnormal_vitamin_homeostasis0.18175504
148MP0001849_ear_inflammation0.18115507
149MP0002118_abnormal_lipid_homeostasis0.17282256
150MP0005365_abnormal_bile_salt0.16945360
151MP0004808_abnormal_hematopoietic_stem0.16844044
152MP0002405_respiratory_system_inflammati0.16757263
153MP0002796_impaired_skin_barrier0.16547720
154MP0002169_no_abnormal_phenotype0.16422515
155MP0002873_normal_phenotype0.16191593
156MP0000313_abnormal_cell_death0.15474807
157MP0006035_abnormal_mitochondrial_morpho0.14684057
158MP0002229_neurodegeneration0.14641233
159MP0010329_abnormal_lipoprotein_level0.14351905
160MP0005423_abnormal_somatic_nervous0.14226739
161MP0001986_abnormal_taste_sensitivity0.14184167
162MP0002970_abnormal_white_adipose0.13977066
163MP0004043_abnormal_pH_regulation0.13919332

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.23195011
2Abnormal respiratory epithelium morphology (HP:0012253)9.23195011
3Abnormal respiratory motile cilium physiology (HP:0012261)9.04420082
4Severe visual impairment (HP:0001141)8.79629304
5Rhinitis (HP:0012384)7.37038932
6Abnormal ciliary motility (HP:0012262)7.26459334
7Infertility (HP:0000789)6.90057779
8Chronic bronchitis (HP:0004469)6.83449159
9Nasal polyposis (HP:0100582)6.41228301
10Bony spicule pigmentary retinopathy (HP:0007737)5.40117553
11Attenuation of retinal blood vessels (HP:0007843)5.31626869
12Abnormality of the nasal mucosa (HP:0000433)5.28591365
13Male infertility (HP:0003251)5.21216367
14Bronchitis (HP:0012387)4.68027870
15Resting tremor (HP:0002322)4.58305284
16Bronchiectasis (HP:0002110)4.47562633
17Hypoplastic ischia (HP:0003175)4.45678462
18Abnormal rod and cone electroretinograms (HP:0008323)4.38861733
19Nephronophthisis (HP:0000090)4.38424670
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.33935657
21Hyperkalemia (HP:0002153)4.28224545
22Facial shape deformation (HP:0011334)4.09528567
23Potter facies (HP:0002009)4.09528567
24Enlarged epiphyses (HP:0010580)4.00363714
25Abnormality of the ischium (HP:0003174)3.96094561
26Abnormality of macular pigmentation (HP:0008002)3.94417128
27Abnormal spermatogenesis (HP:0008669)3.86864770
28Chronic hepatic failure (HP:0100626)3.85779729
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.58554602
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.52593260
31Recurrent otitis media (HP:0000403)3.39134648
32Cone-rod dystrophy (HP:0000548)3.37477795
33Recurrent sinusitis (HP:0011108)3.35251292
34Unilateral renal agenesis (HP:0000122)3.35056792
35Abnormality of the renal medulla (HP:0100957)3.32061389
36Recurrent bronchitis (HP:0002837)3.24413677
37Hypoplasia of the thymus (HP:0000778)3.16978326
38Impulsivity (HP:0100710)3.04666860
39Tubulointerstitial nephritis (HP:0001970)3.02365401
40Postural instability (HP:0002172)2.99849398
41Double outlet right ventricle (HP:0001719)2.98109019
42Congenital malformation of the right heart (HP:0011723)2.98109019
43Abnormality of the aortic arch (HP:0012303)2.88362106
44Generalized aminoaciduria (HP:0002909)2.71773856
45Epiphyseal dysplasia (HP:0002656)2.70184559
46Progressive sensorineural hearing impairment (HP:0000408)2.70108101
47Tubular atrophy (HP:0000092)2.66246487
48Gonadotropin excess (HP:0000837)2.63733422
49Abnormal gallbladder physiology (HP:0012438)2.58588662
50Cholecystitis (HP:0001082)2.58588662
51Tubulointerstitial abnormality (HP:0001969)2.52226347
52Hypoalphalipoproteinemia (HP:0003233)2.51462627
53Abnormality of potassium homeostasis (HP:0011042)2.51166633
54Abnormality of the costochondral junction (HP:0000919)2.49844670
55Abnormality of midbrain morphology (HP:0002418)2.47843471
56Molar tooth sign on MRI (HP:0002419)2.47843471
57Progressive cerebellar ataxia (HP:0002073)2.43668584
58Abnormality of the parathyroid morphology (HP:0011766)2.39807323
59Flattened epiphyses (HP:0003071)2.35324333
60Azoospermia (HP:0000027)2.34189027
61Portal hypertension (HP:0001409)2.25043975
62Spastic tetraparesis (HP:0001285)2.24350924
63Abnormality of the pubic bones (HP:0003172)2.21080879
64Amelogenesis imperfecta (HP:0000705)2.19585040
65Abnormality of the epiphysis of the femoral head (HP:0010574)2.19351994
66Medial flaring of the eyebrow (HP:0010747)2.18616795
67Ventricular tachycardia (HP:0004756)2.17961264
68Renovascular hypertension (HP:0100817)2.17779844
69Abnormality of dental color (HP:0011073)2.12534451
70Insulin-resistant diabetes mellitus (HP:0000831)2.11459494
71Dyschromatopsia (HP:0007641)2.08607661
72Widely patent fontanelles and sutures (HP:0004492)2.07275943
73Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05942606
74Abnormality of femoral epiphyses (HP:0006499)2.05942606
75Abnormality of the hepatic vasculature (HP:0006707)2.04739935
76Heterotopia (HP:0002282)2.04682156
77Hyponatremia (HP:0002902)2.02448353
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02224940
79Osteomalacia (HP:0002749)2.00508551
80Tetany (HP:0001281)2.00116698
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.5934396
82Absent/shortened dynein arms (HP:0200106)13.5934396
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8784296
84Tubulointerstitial fibrosis (HP:0005576)1.99370015
85Abnormal ventriculo-arterial connection (HP:0011563)1.98461221
86Transposition of the great arteries (HP:0001669)1.98461221
87Abnormal connection of the cardiac segments (HP:0011545)1.98461221
88Hypophosphatemic rickets (HP:0004912)1.97478399
89Abnormality of the femoral head (HP:0003368)1.95168412
90Hyperthyroidism (HP:0000836)1.93383518
91Recurrent corneal erosions (HP:0000495)1.91291238
92Mixed hearing impairment (HP:0000410)1.91172012
93Abnormality of the lower motor neuron (HP:0002366)1.91030442
94Menstrual irregularities (HP:0000858)1.90811679
95Choroideremia (HP:0001139)1.90084695
96Recurrent pneumonia (HP:0006532)1.87751098
97Flat capital femoral epiphysis (HP:0003370)1.87701720
98Spastic paraparesis (HP:0002313)1.87453404
99Vertebral clefting (HP:0008428)1.87348116
100Postaxial foot polydactyly (HP:0001830)1.86953945
101Protuberant abdomen (HP:0001538)1.85756429
102Neoplasm of the heart (HP:0100544)1.84332911
103Atelectasis (HP:0100750)1.83477346
104Stage 5 chronic kidney disease (HP:0003774)1.83131665
105Decreased central vision (HP:0007663)1.81644689
106Bell-shaped thorax (HP:0001591)1.81383473
107Short ribs (HP:0000773)1.78828147
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78456283
109Hypoparathyroidism (HP:0000829)1.77612995
110Polydipsia (HP:0001959)1.77161059
111Abnormal drinking behavior (HP:0030082)1.77161059
112Bradycardia (HP:0001662)1.76707196
113Bile duct proliferation (HP:0001408)1.74314846
114Abnormal biliary tract physiology (HP:0012439)1.74314846
115Abnormality of the renal cortex (HP:0011035)1.70914935
116Congenital hepatic fibrosis (HP:0002612)1.70834966
117Hemorrhage of the eye (HP:0011885)1.70720619
118Fibular hypoplasia (HP:0003038)1.63648522
119Abnormality of renal excretion (HP:0011036)1.58944771
120Oculomotor apraxia (HP:0000657)1.58035920
121Absent frontal sinuses (HP:0002688)1.57341349
122Amyotrophic lateral sclerosis (HP:0007354)1.57054560
123Abnormality of dentin (HP:0010299)1.56233931
124Hemiparesis (HP:0001269)1.54829441
125Neurofibrillary tangles (HP:0002185)1.52648378
126Taurodontia (HP:0000679)1.48819957
127Abnormality of permanent molar morphology (HP:0011071)1.48819957
128Abnormality of the dental root (HP:0006486)1.48819957
129Asymmetric septal hypertrophy (HP:0001670)1.47236418
130Deformed sella turcica (HP:0002681)1.46400421
131J-shaped sella turcica (HP:0002680)1.44907663
132Renal dysplasia (HP:0000110)1.43944501
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43720424
134Absent epiphyses (HP:0010577)1.43720424
135Postaxial hand polydactyly (HP:0001162)1.39573194
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.38962250
137Abnormality of molar (HP:0011077)1.37719588
138Abnormality of molar morphology (HP:0011070)1.37719588
139Microglossia (HP:0000171)1.36429639
140Abnormality of the dental pulp (HP:0006479)1.36201726
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.35030217
142Bundle branch block (HP:0011710)1.34682767
143Abnormal urine output (HP:0012590)1.34134826
144Cystic liver disease (HP:0006706)1.32171658
145Cerebral inclusion bodies (HP:0100314)1.32107276
146Broad distal phalanx of finger (HP:0009836)1.31732382
147Facial cleft (HP:0002006)1.31484979
148Short thorax (HP:0010306)1.29914652
149Chronic sinusitis (HP:0011109)1.29804601
150Impaired proprioception (HP:0010831)1.29146877
151Truncal obesity (HP:0001956)1.24862344
152Hypercholesterolemia (HP:0003124)1.24360003
153Nephropathy (HP:0000112)1.22810252
154Glucose intolerance (HP:0000833)1.22487993
155Supernumerary spleens (HP:0009799)1.21926998
156Aplasia/Hypoplasia of the lens (HP:0008063)1.21297216
157Pachygyria (HP:0001302)1.19792847
158Short femoral neck (HP:0100864)1.16359287
159Loss of speech (HP:0002371)1.14812411
160Hyporeflexia of lower limbs (HP:0002600)1.14223978
161Pancreatic fibrosis (HP:0100732)1.13864022
162Lissencephaly (HP:0001339)1.12103591
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.11883008
164Abnormality of saccadic eye movements (HP:0000570)1.10838828
165Polyuria (HP:0000103)1.10540140
166Difficulty climbing stairs (HP:0003551)1.10535726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.87241546
2PDK37.87241546
3TESK16.19337456
4PRKD36.04476251
5DDR25.79024225
6PDK25.08147076
7ICK4.54172351
8MAP4K23.58620868
9INSRR3.53385552
10BRD43.12505716
11PLK22.84490366
12PNCK2.77270918
13PTK2B2.41531827
14WNK42.20138695
15STK392.00203700
16MST1R1.86761175
17STK381.65701932
18DYRK1B1.65012533
19NEK21.49009090
20CDK71.47507138
21PIK3CG1.40146155
22KSR21.17547052
23MAP3K91.13886574
24MAPK151.06213422
25LATS21.03075604
26PDK11.02941160
27TYRO31.01136565
28CAMK1G0.98953921
29WNK10.95213365
30AKT30.85682298
31CAMK1D0.83792889
32RPS6KA20.83504922
33UHMK10.78134471
34DYRK30.77684820
35BRAF0.72610119
36MAP3K110.68879165
37PRKAA20.66573070
38MAP3K20.65545206
39PASK0.65202698
40SIK20.64374109
41ROCK10.61365069
42STK30.61292525
43MAP2K60.61262219
44MAP2K20.58908810
45MAP3K80.58287671
46EEF2K0.57939561
47PDPK10.57507177
48TTK0.57474641
49CCNB10.56046513
50TESK20.55657863
51CHEK20.53241052
52RIPK40.50662908
53LATS10.50402180
54IRAK10.50103156
55LMTK20.49146392
56RPS6KL10.48343231
57RPS6KC10.48343231
58TIE10.47125606
59PAK10.45801260
60CHEK10.45207757
61CDK30.44589571
62RPS6KA60.44124201
63ARAF0.43853054
64BMPR1B0.43300579
65PAK20.39768029
66MTOR0.38577178
67PINK10.38442752
68SGK2230.37699723
69SGK4940.37699723
70MAP3K10.36874401
71WEE10.33426427
72CAMK40.32853271
73CDC70.32203182
74ATM0.31970389
75NEK60.31485276
76PAK40.30980700
77NTRK20.29801303
78MET0.29575129
79CDK120.28676077
80MARK10.28324476
81ATR0.27681214
82MARK20.26962238
83PRKCG0.26830531
84NTRK30.25410243
85STK38L0.25302876
86MAPK100.24657783
87PLK40.24190082
88IRAK20.24123259
89MAPK140.23690286
90MAPK110.23063655
91SGK10.22286403
92FRK0.22158055
93PRKAA10.22017462
94FER0.21507406
95CAMKK10.19377741
96MAP3K100.18932687
97AKT10.17063666
98MUSK0.16246692
99RPS6KB10.16029846
100ACVR1B0.15217550
101MAPKAPK50.14043281
102MAP3K40.13605642
103OXSR10.13192415
104PRKCZ0.12669844
105PLK10.12651352
106CSNK1D0.12579429
107RIPK10.10666423
108IKBKB0.09902658
109CDK60.09885921
110GSK3B0.09341679
111JAK30.08974015
112MAPK90.08748930
113CHUK0.08354396
114CDK150.07836831
115ROCK20.07546778
116BRSK20.07145045
117PRKCQ0.07116184
118TNIK0.06842254
119RPS6KA10.06322885
120PRKACA0.06082689
121CDK20.06005525
122EPHB10.05757541
123CDK90.05486264
124CDK180.05354726
125MAP3K130.05165612
126CDK10.05158679
127CDK11A0.04726525
128CSNK2A10.04483319
129BRSK10.04149007
130CDK40.03999755
131STK110.03518773
132PRKG20.03395365
133CSNK2A20.02777600
134MAPK80.02697305
135PKN10.02463720
136PRKG10.02241334
137MARK30.02131434
138TRIB30.01883457
139STK100.01858718
140WNK30.01725586
141CDK140.01574433
142CAMK2A0.01551761
143PRKCB0.01259831
144PAK60.01064583
145PRKACG0.01060990
146PRKDC0.00706820
147ZAP700.00205761
148CSK0.00176401
149EGFR0.00032297
150CLK10.00019141
151PDGFRB-0.0192166
152TAOK1-0.0190305
153CAMK1-0.0150026
154CSF1R-0.0138221
155RPS6KA3-0.0053886
156PRKACB-0.0043360
157MAPK1-0.0039369

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.23629820
2Fatty acid biosynthesis_Homo sapiens_hsa000614.57795223
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51330648
4Olfactory transduction_Homo sapiens_hsa047403.50352032
5Pyruvate metabolism_Homo sapiens_hsa006203.42937309
6Vitamin B6 metabolism_Homo sapiens_hsa007503.17231446
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.06516238
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84741550
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.76117318
10Linoleic acid metabolism_Homo sapiens_hsa005912.72479369
11Butanoate metabolism_Homo sapiens_hsa006502.66887528
12Propanoate metabolism_Homo sapiens_hsa006402.65604886
13Glucagon signaling pathway_Homo sapiens_hsa049222.50541032
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.47706100
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.16837589
16Dorso-ventral axis formation_Homo sapiens_hsa043202.15097749
17Glycerolipid metabolism_Homo sapiens_hsa005612.08495023
18PPAR signaling pathway_Homo sapiens_hsa033202.02359157
19Selenocompound metabolism_Homo sapiens_hsa004502.00962616
20Basal transcription factors_Homo sapiens_hsa030221.99261317
21Allograft rejection_Homo sapiens_hsa053301.85533808
22Type I diabetes mellitus_Homo sapiens_hsa049401.85243453
23Autoimmune thyroid disease_Homo sapiens_hsa053201.80857963
24Fructose and mannose metabolism_Homo sapiens_hsa000511.77972584
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73885933
26Graft-versus-host disease_Homo sapiens_hsa053321.72304541
27Oocyte meiosis_Homo sapiens_hsa041141.66671180
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.66314168
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.64332497
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56272055
31Phenylalanine metabolism_Homo sapiens_hsa003601.54675328
32Pentose phosphate pathway_Homo sapiens_hsa000301.49482638
33Fatty acid metabolism_Homo sapiens_hsa012121.49449859
34Mineral absorption_Homo sapiens_hsa049781.47675326
35Fatty acid degradation_Homo sapiens_hsa000711.47657560
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.42103760
37Carbon metabolism_Homo sapiens_hsa012001.34385450
38Amphetamine addiction_Homo sapiens_hsa050311.34029647
39Fanconi anemia pathway_Homo sapiens_hsa034601.33326096
40Viral myocarditis_Homo sapiens_hsa054161.32646500
41Antigen processing and presentation_Homo sapiens_hsa046121.31789953
42Fat digestion and absorption_Homo sapiens_hsa049751.29386247
43Arginine and proline metabolism_Homo sapiens_hsa003301.26305037
44Cardiac muscle contraction_Homo sapiens_hsa042601.22668811
45Ether lipid metabolism_Homo sapiens_hsa005651.21788295
46mRNA surveillance pathway_Homo sapiens_hsa030151.20931842
47Huntingtons disease_Homo sapiens_hsa050161.19343847
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.15641537
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14737375
50RNA transport_Homo sapiens_hsa030131.10235153
51Renin secretion_Homo sapiens_hsa049241.08554479
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98151155
53Arginine biosynthesis_Homo sapiens_hsa002200.97374126
54Phototransduction_Homo sapiens_hsa047440.93806944
55Purine metabolism_Homo sapiens_hsa002300.92983336
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91193939
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.89893373
58Biosynthesis of amino acids_Homo sapiens_hsa012300.84612061
59Hedgehog signaling pathway_Homo sapiens_hsa043400.83087325
60Morphine addiction_Homo sapiens_hsa050320.81306604
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80874704
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80543243
63Bile secretion_Homo sapiens_hsa049760.80491459
64Insulin secretion_Homo sapiens_hsa049110.79726311
65Estrogen signaling pathway_Homo sapiens_hsa049150.78856008
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74299382
67Legionellosis_Homo sapiens_hsa051340.72726783
68Thyroid hormone synthesis_Homo sapiens_hsa049180.71636207
69Glutathione metabolism_Homo sapiens_hsa004800.67464907
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.66656457
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64793216
72Tyrosine metabolism_Homo sapiens_hsa003500.63949089
73Protein digestion and absorption_Homo sapiens_hsa049740.63677243
74ABC transporters_Homo sapiens_hsa020100.63538429
75Long-term potentiation_Homo sapiens_hsa047200.63301802
76Arachidonic acid metabolism_Homo sapiens_hsa005900.63207509
77Collecting duct acid secretion_Homo sapiens_hsa049660.63068752
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62908928
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62820267
80Chemical carcinogenesis_Homo sapiens_hsa052040.62725791
81Renin-angiotensin system_Homo sapiens_hsa046140.60537885
82Nicotine addiction_Homo sapiens_hsa050330.59001370
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.58685889
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56523786
85Retinol metabolism_Homo sapiens_hsa008300.54341223
86Calcium signaling pathway_Homo sapiens_hsa040200.52708549
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51760646
88Pancreatic secretion_Homo sapiens_hsa049720.51563019
89Endocytosis_Homo sapiens_hsa041440.50752681
90MAPK signaling pathway_Homo sapiens_hsa040100.50568665
91Salivary secretion_Homo sapiens_hsa049700.49826621
92Glutamatergic synapse_Homo sapiens_hsa047240.49681500
93Tight junction_Homo sapiens_hsa045300.49530510
94Taste transduction_Homo sapiens_hsa047420.48689139
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.48220555
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48067491
97AMPK signaling pathway_Homo sapiens_hsa041520.46590355
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46481574
99Acute myeloid leukemia_Homo sapiens_hsa052210.45227632
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44555741
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43869887
102Gastric acid secretion_Homo sapiens_hsa049710.42682370
103Cholinergic synapse_Homo sapiens_hsa047250.42593719
104Inositol phosphate metabolism_Homo sapiens_hsa005620.41103831
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41057928
106Synaptic vesicle cycle_Homo sapiens_hsa047210.40652994
107Viral carcinogenesis_Homo sapiens_hsa052030.36478326
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35240903
109Circadian entrainment_Homo sapiens_hsa047130.34269570
110Serotonergic synapse_Homo sapiens_hsa047260.34267601
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.33529109
112cAMP signaling pathway_Homo sapiens_hsa040240.32467720
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31940149
114Metabolic pathways_Homo sapiens_hsa011000.31671271
115VEGF signaling pathway_Homo sapiens_hsa043700.30204910
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.28766732
117ECM-receptor interaction_Homo sapiens_hsa045120.28725701
118GABAergic synapse_Homo sapiens_hsa047270.27500259
119Oxytocin signaling pathway_Homo sapiens_hsa049210.26393530
120Prolactin signaling pathway_Homo sapiens_hsa049170.25640613
121Herpes simplex infection_Homo sapiens_hsa051680.21651375
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20548351
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20097025
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19753819
125Adherens junction_Homo sapiens_hsa045200.19655990
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19383768
127N-Glycan biosynthesis_Homo sapiens_hsa005100.18501786
128Sulfur metabolism_Homo sapiens_hsa009200.17876707
129Pyrimidine metabolism_Homo sapiens_hsa002400.17137015
130Cocaine addiction_Homo sapiens_hsa050300.15923576
131Systemic lupus erythematosus_Homo sapiens_hsa053220.15886766
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15752139
133Type II diabetes mellitus_Homo sapiens_hsa049300.15533196
134Toxoplasmosis_Homo sapiens_hsa051450.15345066
135Alcoholism_Homo sapiens_hsa050340.15052053
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13974153
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13670205
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13422484
139Basal cell carcinoma_Homo sapiens_hsa052170.12614126
140HIF-1 signaling pathway_Homo sapiens_hsa040660.11567304
141Insulin resistance_Homo sapiens_hsa049310.10435495
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09097754
143RNA degradation_Homo sapiens_hsa030180.07886722
144Influenza A_Homo sapiens_hsa051640.05915386

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