FAM71F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.98057908
2plasma membrane fusion (GO:0045026)9.75066964
3epithelial cilium movement (GO:0003351)9.70691933
4axonemal dynein complex assembly (GO:0070286)9.59688255
5motile cilium assembly (GO:0044458)9.43135898
6reproduction (GO:0000003)9.15379111
7response to pheromone (GO:0019236)8.89988464
8regulation of cilium movement (GO:0003352)8.87006882
9cilium or flagellum-dependent cell motility (GO:0001539)8.08039580
10cilium movement (GO:0003341)7.75410071
11negative regulation of inclusion body assembly (GO:0090084)7.68801059
12rRNA methylation (GO:0031167)7.34247442
13single fertilization (GO:0007338)7.24041173
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.19692669
15sperm capacitation (GO:0048240)7.18966132
16synaptonemal complex organization (GO:0070193)7.13555715
17synaptonemal complex assembly (GO:0007130)7.01058925
18spermatogenesis (GO:0007283)6.98453057
19male gamete generation (GO:0048232)6.95944017
20organic cation transport (GO:0015695)6.80225697
21microtubule depolymerization (GO:0007019)6.78395000
22male meiosis (GO:0007140)6.74417540
23piRNA metabolic process (GO:0034587)6.74033902
24gamete generation (GO:0007276)6.39363639
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.36627219
26protein targeting to Golgi (GO:0000042)6.36504772
27regulation of inclusion body assembly (GO:0090083)6.35340201
28rRNA modification (GO:0000154)6.31945870
29fertilization (GO:0009566)6.21330527
30establishment of protein localization to Golgi (GO:0072600)6.12476735
31chromosome condensation (GO:0030261)5.88467142
32phosphatidylethanolamine metabolic process (GO:0046337)5.88006678
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.86951170
34calcium ion-dependent exocytosis (GO:0017156)5.71420393
35DNA packaging (GO:0006323)5.56767153
36centriole replication (GO:0007099)5.56353582
37germ cell development (GO:0007281)5.52607441
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.40131529
39cellular ketone body metabolic process (GO:0046950)5.37999913
40glycerol ether metabolic process (GO:0006662)5.26964293
41regulation of microtubule-based movement (GO:0060632)5.24899366
42spermatid nucleus differentiation (GO:0007289)5.15610906
43multicellular organismal reproductive process (GO:0048609)5.03375294
44ventricular system development (GO:0021591)5.01596000
45cell recognition (GO:0008037)5.00800028
46ether metabolic process (GO:0018904)4.86850175
47microtubule severing (GO:0051013)4.80463029
48centriole assembly (GO:0098534)4.77762795
49positive regulation of Rab GTPase activity (GO:0032851)4.77416424
50regulation of Rab GTPase activity (GO:0032313)4.77416424
51seminiferous tubule development (GO:0072520)4.74489417
52ketone body metabolic process (GO:1902224)4.73144457
53chromosome organization involved in meiosis (GO:0070192)4.71375598
54male meiosis I (GO:0007141)4.69874946
55regulation of centriole replication (GO:0046599)4.69098653
56sexual reproduction (GO:0019953)4.65595212
57protein localization to Golgi apparatus (GO:0034067)4.59736209
58left/right pattern formation (GO:0060972)4.44224211
59chaperone-mediated protein complex assembly (GO:0051131)4.43033130
60single strand break repair (GO:0000012)4.41804878
61regulation of transcription involved in cell fate commitment (GO:0060850)4.40485565
62DNA methylation involved in gamete generation (GO:0043046)4.34077118
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13517854
64meiotic nuclear division (GO:0007126)4.08888135
65multicellular organismal development (GO:0007275)4.06249811
66nucleosome disassembly (GO:0006337)3.88791527
67protein-DNA complex disassembly (GO:0032986)3.88791527
68sequestering of actin monomers (GO:0042989)3.86022024
69meiosis I (GO:0007127)3.75835122
70coenzyme catabolic process (GO:0009109)3.59801997
71musculoskeletal movement (GO:0050881)3.58965229
72multicellular organismal movement (GO:0050879)3.58965229
73genitalia morphogenesis (GO:0035112)3.53763805
74protein polyglutamylation (GO:0018095)3.51624409
75protein refolding (GO:0042026)3.49275497
76negative regulation of gene expression, epigenetic (GO:0045814)3.49185098
77regulation of spindle checkpoint (GO:0090231)3.48797244
78microtubule polymerization or depolymerization (GO:0031109)3.46584972
79glomerular visceral epithelial cell development (GO:0072015)3.45690851
80protein K11-linked deubiquitination (GO:0035871)3.42265509
81negative regulation of Rho protein signal transduction (GO:0035024)3.41634327
82peptidyl-threonine dephosphorylation (GO:0035970)3.38931885
83histone exchange (GO:0043486)3.35680308
84glomerular epithelial cell development (GO:0072310)3.31081466
85glycolytic process (GO:0006096)3.30720188
86meiotic cell cycle (GO:0051321)3.28281869
87response to acidic pH (GO:0010447)3.27998729
88mitotic sister chromatid cohesion (GO:0007064)3.25601465
89nucleus organization (GO:0006997)3.21531279
90DNA conformation change (GO:0071103)3.19139086
91interferon-gamma secretion (GO:0072643)3.18905357
92regulation of interleukin-13 production (GO:0032656)3.17146634
93negative regulation of histone methylation (GO:0031061)3.17022520
94histone H3-K9 demethylation (GO:0033169)3.15148513
95cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.15024731
96homeostasis of number of cells within a tissue (GO:0048873)3.10861659
97positive regulation of macrophage activation (GO:0043032)3.10367744
98nucleoside diphosphate phosphorylation (GO:0006165)3.08497088
99amino-acid betaine transport (GO:0015838)3.07732834
100carnitine transport (GO:0015879)3.07732834
101monoubiquitinated protein deubiquitination (GO:0035520)3.06968805
102RNA localization (GO:0006403)3.02567492
103cerebral cortex neuron differentiation (GO:0021895)3.02393834
104polyol catabolic process (GO:0046174)3.01584703
105cellular response to pH (GO:0071467)3.00775062
106polyamine biosynthetic process (GO:0006596)2.96062645
107RNA destabilization (GO:0050779)2.94804987
108protein localization to cilium (GO:0061512)2.94388010
109alditol metabolic process (GO:0019400)2.90529671
110carnitine transmembrane transport (GO:1902603)2.88879020
111chromatin silencing (GO:0006342)2.88301450
112mitochondrial fission (GO:0000266)2.88080847
113GTP biosynthetic process (GO:0006183)2.84982620
114mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84579056
115mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84579056
116microtubule nucleation (GO:0007020)2.83167661
117regulation of T-helper 2 cell differentiation (GO:0045628)2.82923347
118cranial nerve morphogenesis (GO:0021602)2.78373075
119meiotic cell cycle process (GO:1903046)2.76496061
120cell differentiation involved in metanephros development (GO:0072202)2.76355292
121protein depolymerization (GO:0051261)2.76135379
122regulation of cilium assembly (GO:1902017)2.72325059
123regulation of somitogenesis (GO:0014807)2.71161003
124cilium organization (GO:0044782)2.67600819
125synapsis (GO:0007129)2.66459188
126mitochondrion degradation (GO:0000422)2.64789493
127microtubule-based movement (GO:0007018)2.62318254
128cilium morphogenesis (GO:0060271)2.57583932
129cilium assembly (GO:0042384)2.56781773
130cellular component assembly involved in morphogenesis (GO:0010927)2.56254086
131UTP biosynthetic process (GO:0006228)2.55774240
132membrane protein intracellular domain proteolysis (GO:0031293)2.50489987
133negative regulation of organelle assembly (GO:1902116)2.46144869
134axoneme assembly (GO:0035082)2.45227752
135intraciliary transport (GO:0042073)2.44402944
136peptidyl-glutamic acid modification (GO:0018200)2.43253597
137lactate metabolic process (GO:0006089)2.41497653
138sperm motility (GO:0030317)14.4701222
139fusion of sperm to egg plasma membrane (GO:0007342)12.8039955
140cell wall macromolecule metabolic process (GO:0044036)12.7319362
141cell wall macromolecule catabolic process (GO:0016998)12.7319362
142acrosome reaction (GO:0007340)12.6941225
143sperm-egg recognition (GO:0035036)11.5785542
144acrosome assembly (GO:0001675)11.4380559
145binding of sperm to zona pellucida (GO:0007339)10.6769510
146multicellular organism reproduction (GO:0032504)10.4388879
147cell-cell recognition (GO:0009988)10.3611361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.39622807
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.84332721
3EZH2_22144423_ChIP-Seq_EOC_Human4.18568038
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87749935
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79893163
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.29181745
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14587327
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90801749
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88672535
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69938674
11VDR_22108803_ChIP-Seq_LS180_Human2.55839498
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35677909
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.31591715
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27060559
15FUS_26573619_Chip-Seq_HEK293_Human2.19799204
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11377255
17ZNF274_21170338_ChIP-Seq_K562_Hela2.07821091
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05567509
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.98016676
20ERA_21632823_ChIP-Seq_H3396_Human1.94456014
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84730076
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84706830
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.84496716
24RAC3_21632823_ChIP-Seq_H3396_Human1.81618656
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81357664
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78368656
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78060753
28* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76784240
29STAT1_17558387_ChIP-Seq_HELA_Human1.74118651
30DROSHA_22980978_ChIP-Seq_HELA_Human1.74113596
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.73547438
32CTCF_27219007_Chip-Seq_Bcells_Human1.73036600
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69086414
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66765522
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.63442479
36ER_23166858_ChIP-Seq_MCF-7_Human1.63375460
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.63205747
38TAF2_19829295_ChIP-Seq_ESCs_Human1.60583293
39AR_25329375_ChIP-Seq_VCAP_Human1.60561172
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.60247817
41P300_19829295_ChIP-Seq_ESCs_Human1.59080433
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58068932
43MYC_19829295_ChIP-Seq_ESCs_Human1.55091532
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54062757
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.50001770
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49425101
47RBPJ_21746931_ChIP-Seq_IB4_Human1.49152218
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.48819859
49BCL6_27268052_Chip-Seq_Bcells_Human1.48380568
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.48037412
51TP53_18474530_ChIP-ChIP_U2OS_Human1.47240664
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.46687110
53OCT4_20526341_ChIP-Seq_ESCs_Human1.46331286
54* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46036971
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.45490283
56E2F1_20622854_ChIP-Seq_HELA_Human1.44818430
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.44316704
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44201387
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43538960
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.42612753
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42282597
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41734386
63SMC4_20622854_ChIP-Seq_HELA_Human1.41680360
64KDM2B_26808549_Chip-Seq_REH_Human1.41465142
65P53_21459846_ChIP-Seq_SAOS-2_Human1.40309918
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.39575701
67ETV1_20927104_ChIP-Seq_GIST48_Human1.39537483
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38727803
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38212929
70CBP_20019798_ChIP-Seq_JUKART_Human1.38212929
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37387673
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.36364770
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34044313
74P68_20966046_ChIP-Seq_HELA_Human1.32639859
75TP63_22573176_ChIP-Seq_HFKS_Human1.32197585
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32101827
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30276865
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30172814
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30058742
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29426956
81RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29426106
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.28737737
83REST_21632747_ChIP-Seq_MESCs_Mouse1.27922928
84TBL1_22424771_ChIP-Seq_293T_Human1.27853996
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.27221610
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25954416
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25681243
88P300_27268052_Chip-Seq_Bcells_Human1.24984688
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24252250
90PHF8_20622853_ChIP-Seq_HELA_Human1.23351107
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22670912
92CEBPB_22108803_ChIP-Seq_LS180_Human1.22602178
93GF1_26923725_Chip-Seq_HPCs_Mouse1.22010520
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.21797149
95CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20776658
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20550912
97RUNX2_22187159_ChIP-Seq_PCA_Human1.19897825
98SOX2_19829295_ChIP-Seq_ESCs_Human1.19451789
99NANOG_19829295_ChIP-Seq_ESCs_Human1.19451789
100SPI1_26923725_Chip-Seq_HPCs_Mouse1.18664888
101* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18375589
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18323864
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18123743
104P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17635320
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.17472112
106* SMAD4_21741376_ChIP-Seq_HESCs_Human1.16698251
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.16664214
108SMAD4_21799915_ChIP-Seq_A2780_Human1.16648722
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16644876
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14844329
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.14786061
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14665489
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13972155
114GATA6_21074721_ChIP-Seq_CACO-2_Human1.13847709
115SMRT_27268052_Chip-Seq_Bcells_Human1.13581044
116MYC_27129775_Chip-Seq_CORNEA_Mouse1.12909858
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12638050
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.12041914
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10857751
120ERG_20517297_ChIP-Seq_VCAP_Human1.10470646
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10155274
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10078967
123NFYA_21822215_ChIP-Seq_K562_Human1.09978685
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09829727
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09672118
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09672118
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09510158
128* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09399555
129RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08234815
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.07674276
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07391382
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07064317
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.06895588
134ESET_19884257_ChIP-Seq_ESCs_Mouse1.06210674
135OCT1_27270436_Chip-Seq_PROSTATE_Human1.05111893
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04504388
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03658001
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03561565
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03213345
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03186473
141HOXB7_26014856_ChIP-Seq_BT474_Human1.02938195
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02805967
143SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00790696
144* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00539050
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.98394056
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97853003
147* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96938191
148CRX_20693478_ChIP-Seq_RETINA_Mouse0.96924121
149* CTCF_20526341_ChIP-Seq_ESCs_Human0.95931069
150BCOR_27268052_Chip-Seq_Bcells_Human0.95527875
151SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95289222
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94859022
153FLI1_21867929_ChIP-Seq_CD8_Mouse0.94842930
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93126518
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.91399660
156TAF15_26573619_Chip-Seq_HEK293_Human0.90845925
157NFYB_21822215_ChIP-Seq_K562_Human0.90819009
158* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90302772
159NANOG_20526341_ChIP-Seq_ESCs_Human0.89074718
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88576133
161SOX2_21211035_ChIP-Seq_LN229_Human0.86964019
162PHF8_20622854_ChIP-Seq_HELA_Human0.86616584
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86103370
164SOX9_26525672_Chip-Seq_HEART_Mouse0.84954770
165KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84944937
166STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84832944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04303232
2MP0001929_abnormal_gametogenesis5.52435386
3MP0008877_abnormal_DNA_methylation3.77116625
4MP0002161_abnormal_fertility/fecundity3.31779093
5MP0002210_abnormal_sex_determination3.29281590
6MP0005670_abnormal_white_adipose3.19388760
7MP0001145_abnormal_male_reproductive2.78793005
8MP0003718_maternal_effect2.43973544
9MP0000653_abnormal_sex_gland2.39914967
10MP0000678_abnormal_parathyroid_gland2.32950380
11MP0005410_abnormal_fertilization16.7745111
12MP0002653_abnormal_ependyma_morphology1.97955227
13MP0005379_endocrine/exocrine_gland_phen1.82490885
14MP0002132_abnormal_respiratory_system1.75589456
15MP0001485_abnormal_pinna_reflex1.64418530
16MP0009053_abnormal_anal_canal1.59178884
17MP0004233_abnormal_muscle_weight1.50085338
18MP0001486_abnormal_startle_reflex1.49670775
19MP0002249_abnormal_larynx_morphology1.47926648
20MP0002160_abnormal_reproductive_system1.47690067
21MP0003646_muscle_fatigue1.45028558
22MP0005623_abnormal_meninges_morphology1.42689253
23MP0005423_abnormal_somatic_nervous1.42403079
24MP0002735_abnormal_chemical_nociception1.40998325
25MP0005310_abnormal_salivary_gland1.19172437
26MP0004859_abnormal_synaptic_plasticity1.18228303
27MP0002282_abnormal_trachea_morphology1.14075454
28MP0006292_abnormal_olfactory_placode1.12097013
29MP0001963_abnormal_hearing_physiology1.10699140
30MP0002138_abnormal_hepatobiliary_system1.09413161
31MP0001765_abnormal_ion_homeostasis1.08691602
32MP0000049_abnormal_middle_ear1.05792092
33MP0005395_other_phenotype1.01667675
34MP0002822_catalepsy1.01192443
35MP0005248_abnormal_Harderian_gland1.01141134
36MP0003119_abnormal_digestive_system0.99745292
37MP0002234_abnormal_pharynx_morphology0.99218972
38MP0000026_abnormal_inner_ear0.98510677
39MP0004510_myositis0.96720680
40MP0002127_abnormal_cardiovascular_syste0.94858715
41MP0001984_abnormal_olfaction0.90841875
42MP0000955_abnormal_spinal_cord0.83652971
43MP0005367_renal/urinary_system_phenotyp0.82906614
44MP0000516_abnormal_urinary_system0.82906614
45MP0002229_neurodegeneration0.82843578
46MP0003115_abnormal_respiratory_system0.80110053
47MP0005083_abnormal_biliary_tract0.77289641
48MP0008058_abnormal_DNA_repair0.77251046
49MP0005647_abnormal_sex_gland0.77131411
50MP0002067_abnormal_sensory_capabilities0.76207147
51MP0003077_abnormal_cell_cycle0.75898207
52MP0002557_abnormal_social/conspecific_i0.73925319
53MP0005389_reproductive_system_phenotype0.73047323
54MP0004085_abnormal_heartbeat0.69677421
55MP0000566_synostosis0.69028314
56MP0003878_abnormal_ear_physiology0.68925109
57MP0005377_hearing/vestibular/ear_phenot0.68925109
58MP0002733_abnormal_thermal_nociception0.67466454
59MP0005666_abnormal_adipose_tissue0.67092599
60MP0003011_delayed_dark_adaptation0.66576856
61MP0002254_reproductive_system_inflammat0.65718378
62MP0004957_abnormal_blastocyst_morpholog0.65502959
63MP0009697_abnormal_copulation0.64724539
64MP0002734_abnormal_mechanical_nocicepti0.64699462
65MP0008569_lethality_at_weaning0.64498226
66MP0005084_abnormal_gallbladder_morpholo0.64268792
67MP0008995_early_reproductive_senescence0.63664061
68MP0001666_abnormal_nutrient_absorption0.59879450
69MP0003329_amyloid_beta_deposits0.59175346
70MP0005636_abnormal_mineral_homeostasis0.58467729
71MP0003137_abnormal_impulse_conducting0.57370082
72MP0009046_muscle_twitch0.57024962
73MP0000569_abnormal_digit_pigmentation0.54352102
74MP0009745_abnormal_behavioral_response0.54181917
75MP0001879_abnormal_lymphatic_vessel0.54116081
76MP0002269_muscular_atrophy0.53849096
77MP0001324_abnormal_eye_pigmentation0.53543905
78MP0000681_abnormal_thyroid_gland0.53298276
79MP0000358_abnormal_cell_content/0.52919068
80MP0002572_abnormal_emotion/affect_behav0.52187163
81MP0004036_abnormal_muscle_relaxation0.51374749
82MP0001440_abnormal_grooming_behavior0.50967795
83MP0000534_abnormal_ureter_morphology0.50722664
84MP0003283_abnormal_digestive_organ0.50377674
85MP0001905_abnormal_dopamine_level0.49928601
86MP0002272_abnormal_nervous_system0.49738782
87MP0001764_abnormal_homeostasis0.48264796
88MP0001293_anophthalmia0.47871129
89MP0002736_abnormal_nociception_after0.47671097
90MP0001970_abnormal_pain_threshold0.47533313
91MP0005451_abnormal_body_composition0.47118924
92MP0001545_abnormal_hematopoietic_system0.46323518
93MP0005397_hematopoietic_system_phenotyp0.46323518
94MP0010094_abnormal_chromosome_stability0.46006705
95MP0009278_abnormal_bone_marrow0.45675429
96MP0001501_abnormal_sleep_pattern0.45565358
97MP0000613_abnormal_salivary_gland0.45374173
98MP0003699_abnormal_female_reproductive0.45125584
99MP0000470_abnormal_stomach_morphology0.44440234
100MP0003936_abnormal_reproductive_system0.43263263
101MP0003880_abnormal_central_pattern0.43227093
102MP0003693_abnormal_embryo_hatching0.42833395
103MP0004484_altered_response_of0.41961680
104MP0003111_abnormal_nucleus_morphology0.39967814
105MP0001299_abnormal_eye_distance/0.39184605
106MP0009115_abnormal_fat_cell0.39093607
107MP0008789_abnormal_olfactory_epithelium0.38138431
108MP0003942_abnormal_urinary_system0.37661720
109MP0003136_yellow_coat_color0.37523333
110MP0003950_abnormal_plasma_membrane0.36795040
111MP0005253_abnormal_eye_physiology0.35964443
112MP0001730_embryonic_growth_arrest0.35005550
113MP0006036_abnormal_mitochondrial_physio0.33994678
114MP0004133_heterotaxia0.33864748
115MP0002928_abnormal_bile_duct0.33833570
116MP0002295_abnormal_pulmonary_circulatio0.32426350
117MP0005391_vision/eye_phenotype0.30250055
118MP0001849_ear_inflammation0.30141398
119MP0005551_abnormal_eye_electrophysiolog0.29514091
120MP0002971_abnormal_brown_adipose0.28219921
121MP0004811_abnormal_neuron_physiology0.27226183
122MP0000604_amyloidosis0.27082356
123MP0005375_adipose_tissue_phenotype0.25478103
124MP0003861_abnormal_nervous_system0.24609941
125MP0003948_abnormal_gas_homeostasis0.24205381
126MP0002169_no_abnormal_phenotype0.23634197
127MP0002873_normal_phenotype0.23424647
128MP0003633_abnormal_nervous_system0.22655808
129MP0001119_abnormal_female_reproductive0.21986181
130MP0001727_abnormal_embryo_implantation0.21140111
131MP0010307_abnormal_tumor_latency0.20985116
132MP0001968_abnormal_touch/_nociception0.20442632
133MP0008007_abnormal_cellular_replicative0.20150761
134MP0002152_abnormal_brain_morphology0.19966810
135MP0002102_abnormal_ear_morphology0.19951359
136MP0002092_abnormal_eye_morphology0.19550750
137MP0001348_abnormal_lacrimal_gland0.19503492
138MP0003879_abnormal_hair_cell0.19439760
139MP0006035_abnormal_mitochondrial_morpho0.18401085
140MP0003631_nervous_system_phenotype0.18378152
141MP0005503_abnormal_tendon_morphology0.18316093
142MP0003786_premature_aging0.18044860
143MP0004019_abnormal_vitamin_homeostasis0.17932894
144MP0000751_myopathy0.17690236
145MP0002139_abnormal_hepatobiliary_system0.17242784
146MP0003279_aneurysm0.16656117
147MP0004808_abnormal_hematopoietic_stem0.16645277
148MP0002084_abnormal_developmental_patter0.16496528
149MP0003959_abnormal_lean_body0.15932646
150MP0008961_abnormal_basal_metabolism0.15680805
151MP0005380_embryogenesis_phenotype0.15437666
152MP0001672_abnormal_embryogenesis/_devel0.15437666
153MP0000313_abnormal_cell_death0.15193223
154MP0008770_decreased_survivor_rate0.14969798
155MP0004742_abnormal_vestibular_system0.14341138
156MP0003787_abnormal_imprinting0.14315077
157MP0000001_mammalian_phenotype0.13940976
158MP0004145_abnormal_muscle_electrophysio0.13875682
159MP0004087_abnormal_muscle_fiber0.13872146
160MP0001697_abnormal_embryo_size0.13805841
161MP0003045_fibrosis0.13326389
162MP0001661_extended_life_span0.12885918

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.35780563
2Abnormal respiratory epithelium morphology (HP:0012253)9.35780563
3Abnormal respiratory motile cilium physiology (HP:0012261)9.28242000
4Severe visual impairment (HP:0001141)8.13867030
5Chronic bronchitis (HP:0004469)7.37334396
6Rhinitis (HP:0012384)7.32471096
7Infertility (HP:0000789)7.21422668
8Abnormal ciliary motility (HP:0012262)7.21205791
9Nasal polyposis (HP:0100582)6.40023674
10Abnormality of the nasal mucosa (HP:0000433)5.26647617
11Male infertility (HP:0003251)5.14762845
12Attenuation of retinal blood vessels (HP:0007843)4.96025487
13Bony spicule pigmentary retinopathy (HP:0007737)4.95521961
14Bronchitis (HP:0012387)4.58027581
15Chronic hepatic failure (HP:0100626)4.54374619
16Hyperkalemia (HP:0002153)4.48197706
17Bronchiectasis (HP:0002110)4.31969544
18Resting tremor (HP:0002322)4.30316997
19Abnormality of macular pigmentation (HP:0008002)4.16354433
20Nephronophthisis (HP:0000090)4.03474714
21Abnormal rod and cone electroretinograms (HP:0008323)3.88428226
22Abnormal spermatogenesis (HP:0008669)3.73720002
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.72211771
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.71016142
25Facial shape deformation (HP:0011334)3.70113386
26Potter facies (HP:0002009)3.70113386
27Cone-rod dystrophy (HP:0000548)3.63337096
28Hypoplastic ischia (HP:0003175)3.39718741
29Recurrent otitis media (HP:0000403)3.26844272
30Recurrent sinusitis (HP:0011108)3.18359681
31Progressive sensorineural hearing impairment (HP:0000408)3.04206497
32Abnormality of the ischium (HP:0003174)3.01417722
33Abnormality of the renal medulla (HP:0100957)2.99649525
34Hypoplasia of the thymus (HP:0000778)2.99434757
35Unilateral renal agenesis (HP:0000122)2.87685907
36Enlarged epiphyses (HP:0010580)2.86003671
37Progressive cerebellar ataxia (HP:0002073)2.83553254
38Impulsivity (HP:0100710)2.77831668
39Postural instability (HP:0002172)2.72357268
40Recurrent bronchitis (HP:0002837)2.71823038
41Abnormality of the parathyroid morphology (HP:0011766)2.70630835
42Tubulointerstitial nephritis (HP:0001970)2.70157232
43Hypoalphalipoproteinemia (HP:0003233)2.69173914
44Abnormality of the aortic arch (HP:0012303)2.65939634
45Abnormal gallbladder physiology (HP:0012438)2.61600124
46Cholecystitis (HP:0001082)2.61600124
47Abnormality of potassium homeostasis (HP:0011042)2.59083741
48Tubular atrophy (HP:0000092)2.55619387
49Amelogenesis imperfecta (HP:0000705)2.53558547
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50973333
51Generalized aminoaciduria (HP:0002909)2.49426890
52Molar tooth sign on MRI (HP:0002419)2.45770204
53Abnormality of midbrain morphology (HP:0002418)2.45770204
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39806886
55Optic nerve hypoplasia (HP:0000609)2.37438829
56Portal hypertension (HP:0001409)2.34829696
57Tubulointerstitial abnormality (HP:0001969)2.33742036
58Gonadotropin excess (HP:0000837)2.33168366
59Osteomalacia (HP:0002749)2.32966302
60Insulin-resistant diabetes mellitus (HP:0000831)2.32614704
61Renovascular hypertension (HP:0100817)2.27384123
62Abnormality of dental color (HP:0011073)2.27181465
63Dyschromatopsia (HP:0007641)2.24953477
64Abnormality of the hepatic vasculature (HP:0006707)2.23126533
65Polyuria (HP:0000103)2.21647231
66Hyponatremia (HP:0002902)2.19714458
67Azoospermia (HP:0000027)2.19242182
68Abnormality of the costochondral junction (HP:0000919)2.14060053
69Medial flaring of the eyebrow (HP:0010747)2.13248124
70Choroideremia (HP:0001139)2.12293362
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09680015
72Menstrual irregularities (HP:0000858)2.07092983
73Hypophosphatemic rickets (HP:0004912)2.06681241
74Ventricular tachycardia (HP:0004756)2.03883324
75Myokymia (HP:0002411)2.03580188
76Spastic tetraparesis (HP:0001285)2.01185060
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.6672920
78Absent/shortened dynein arms (HP:0200106)13.6672920
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8909762
80Pendular nystagmus (HP:0012043)1.96419710
81Increased purine levels (HP:0004368)1.91888512
82Hyperuricemia (HP:0002149)1.91888512
83Tubulointerstitial fibrosis (HP:0005576)1.90726658
84Decreased central vision (HP:0007663)1.90481657
85Progressive hearing impairment (HP:0001730)1.90289130
86Mixed hearing impairment (HP:0000410)1.89924147
87Abnormality of the pubic bones (HP:0003172)1.89804465
88Epiphyseal dysplasia (HP:0002656)1.87962647
89Upper limb muscle weakness (HP:0003484)1.87780258
90Flattened epiphyses (HP:0003071)1.84304209
91Hemorrhage of the eye (HP:0011885)1.84214802
92Transposition of the great arteries (HP:0001669)1.82603858
93Abnormal connection of the cardiac segments (HP:0011545)1.82603858
94Abnormal ventriculo-arterial connection (HP:0011563)1.82603858
95Recurrent corneal erosions (HP:0000495)1.81918639
96Widely patent fontanelles and sutures (HP:0004492)1.79864896
97Abnormality of chloride homeostasis (HP:0011422)1.79656394
98Intellectual disability, moderate (HP:0002342)1.77596776
99Congenital malformation of the right heart (HP:0011723)1.76719857
100Double outlet right ventricle (HP:0001719)1.76719857
101Abnormality of the epiphysis of the femoral head (HP:0010574)1.76708836
102Tetany (HP:0001281)1.76496968
103Heterotopia (HP:0002282)1.76138303
104Esophageal atresia (HP:0002032)1.73870343
105Stage 5 chronic kidney disease (HP:0003774)1.73577404
106Spastic paraparesis (HP:0002313)1.73522924
107Neurofibrillary tangles (HP:0002185)1.71246902
108Postaxial foot polydactyly (HP:0001830)1.68286958
109Polydipsia (HP:0001959)1.66173428
110Abnormal drinking behavior (HP:0030082)1.66173428
111Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63399392
112Bell-shaped thorax (HP:0001591)1.62858346
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60982996
114Abnormal biliary tract physiology (HP:0012439)1.58767695
115Bile duct proliferation (HP:0001408)1.58767695
116Abnormality of renal excretion (HP:0011036)1.55760491
117Congenital hepatic fibrosis (HP:0002612)1.55677064
118Abnormality of dentin (HP:0010299)1.54519097
119Short ribs (HP:0000773)1.54479387
120Asymmetric septal hypertrophy (HP:0001670)1.54401744
121Abnormality of the renal cortex (HP:0011035)1.48615274
122Oculomotor apraxia (HP:0000657)1.46611751
123Aplasia/Hypoplasia of the lens (HP:0008063)1.43127726
124Bundle branch block (HP:0011710)1.43000896
125Cerebral inclusion bodies (HP:0100314)1.42380256
126Exercise-induced myalgia (HP:0003738)1.40960872
127Abnormality of the dental root (HP:0006486)1.37585932
128Taurodontia (HP:0000679)1.37585932
129Abnormality of permanent molar morphology (HP:0011071)1.37585932
130Easy fatigability (HP:0003388)1.37389750
131Myoglobinuria (HP:0002913)1.36713655
132Fibular hypoplasia (HP:0003038)1.36319182
133Renal dysplasia (HP:0000110)1.32639182
134Facial cleft (HP:0002006)1.31957714
135Abnormality of the lower motor neuron (HP:0002366)1.31550085
136Abnormal urine output (HP:0012590)1.31102436
137Cystic liver disease (HP:0006706)1.30465284
138Deformed sella turcica (HP:0002681)1.30400359
139Postaxial hand polydactyly (HP:0001162)1.30038496
140Constricted visual fields (HP:0001133)1.29485453
141Loss of speech (HP:0002371)1.29063735
142Abnormality of the dental pulp (HP:0006479)1.28770757
143Broad distal phalanx of finger (HP:0009836)1.28621805
144Hypercholesterolemia (HP:0003124)1.27670243
145Sensory axonal neuropathy (HP:0003390)1.27604361
146Fatigable weakness (HP:0003473)1.26693379
147Abnormality of the neuromuscular junction (HP:0003398)1.26693379
148Abnormality of molar (HP:0011077)1.26297474
149Abnormality of molar morphology (HP:0011070)1.26297474
150Rhabdomyolysis (HP:0003201)1.25495022
151Absent epiphyses (HP:0010577)1.25048902
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25048902
153Cerebellar dysplasia (HP:0007033)1.25044899
154Hemiparesis (HP:0001269)1.21429647
155Amyotrophic lateral sclerosis (HP:0007354)1.18879196
156Short nail (HP:0001799)1.17843024
157Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.17651933
158Neoplasm of the heart (HP:0100544)1.16001806
159Generalized muscle weakness (HP:0003324)1.15628516
160Truncal obesity (HP:0001956)1.15556687
161Short thorax (HP:0010306)1.13678997
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.13638037
163Difficulty climbing stairs (HP:0003551)1.13387066
164Absent frontal sinuses (HP:0002688)1.12969095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.91271984
2PDK47.91271984
3TESK16.70253071
4PRKD35.47647557
5PDK25.11525186
6ICK4.78508235
7DDR24.10098872
8INSRR3.71029782
9PLK23.29109443
10BRD43.24151453
11MAP4K23.13246418
12PTK2B2.18686603
13WNK42.02912952
14STK381.93396459
15STK391.92483981
16PNCK1.79049638
17DYRK1B1.70635398
18PIK3CG1.61808130
19NEK21.61071091
20MAP3K91.38418927
21CDK71.29040116
22PDK11.22355721
23CDK121.20435237
24LATS20.98565756
25DYRK30.96535745
26TYRO30.84725844
27CAMK1D0.84555821
28AKT30.82119780
29PDPK10.81740466
30MAPK150.80687530
31BMPR1B0.79123722
32CDK190.78970035
33PASK0.78593161
34UHMK10.78356698
35WNK10.77567901
36EEF2K0.77548801
37IRAK10.74130819
38TESK20.72975800
39TNIK0.72956622
40CASK0.72481317
41OXSR10.70531334
42RIPK40.69144525
43LATS10.66162437
44KSR20.64918428
45TTK0.62758414
46STK30.61765096
47CAMK10.59804466
48CCNB10.59551942
49CHEK20.57490046
50PRKAA20.55623864
51MAP2K60.50774788
52PINK10.50181456
53MAP3K80.49886784
54CDK30.49274163
55SGK2230.49041139
56SGK4940.49041139
57MAP3K40.48923921
58CAMK1G0.47929160
59TIE10.47910014
60FRK0.47355278
61PAK10.46879519
62ROCK10.46859618
63MAP2K20.45950143
64ZAK0.45347944
65RPS6KA20.43436434
66STK38L0.41621722
67IRAK20.41374096
68MAP3K100.40043265
69MUSK0.40008367
70MAPK10.39028253
71NTRK20.38831405
72PAK20.37684183
73TAF10.37026751
74CHEK10.36932668
75MAP3K110.36323096
76SIK20.35656391
77LMTK20.35592840
78PAK40.35168327
79PRKCG0.34948771
80DYRK20.31787014
81CAMKK10.30973835
82MAP3K20.30820527
83MET0.29706199
84MTOR0.28723916
85MAPKAPK50.27919322
86MAPK140.27748154
87WNK30.27084358
88NUAK10.26946794
89SGK10.26593974
90MARK10.26454486
91MARK20.25789234
92CAMK40.25568470
93ATM0.24897877
94WEE10.24483738
95ACVR1B0.24119719
96MAPK100.23292596
97ATR0.22521890
98PLK40.22081371
99MKNK20.21948932
100SRPK10.21736467
101RPS6KA60.20888109
102NME10.20691929
103RPS6KC10.20473580
104RPS6KL10.20473580
105AKT10.20211659
106BRSK20.20079836
107ERBB40.19731053
108CDK150.19471519
109PRKCZ0.19446501
110MAP3K70.18247644
111TRIB30.17245096
112CDC70.16970093
113CDK180.16584601
114NTRK30.16269011
115PRKAA10.16092137
116SGK20.15547022
117CDK11A0.15540366
118PLK10.14537512
119BRAF0.13685799
120PRKG20.13313736
121STK100.12516489
122PRKCQ0.12483045
123BRSK10.12410942
124NEK60.12081685
125RPS6KB10.11824609
126CDK140.11709801
127MARK30.10213743
128RPS6KA10.09491998
129CDK60.08158024
130CSNK2A10.06752905
131GSK3B0.05972464
132TTN0.05187019
133PIM10.04007206
134CDK20.03016819
135CSF1R0.02905661
136CDK10.02407239
137PRKCD0.02200687
138PAK60.01786304
139AURKA0.01745374
140MST1R0.01629229
141PRKG10.01602612
142CSNK1D0.01519044
143MAPK80.01190851
144PRKACG0.00899553
145CAMK2A0.00824022
146PRKCB0.00630515
147CSNK2A20.00480512
148STK110.00164522
149PRKDC-0.0479505
150EPHB1-0.0434362
151BUB1-0.0423385
152PKN1-0.0364710
153PRKACB-0.0333528
154RPS6KA3-0.0321985
155PDGFRB-0.0314439
156EGFR-0.0252426
157CLK1-0.0171520
158PRKCA-0.0041275
159CDK4-0.0027830

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.09377553
2Fatty acid biosynthesis_Homo sapiens_hsa000614.88614276
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.59965184
4Olfactory transduction_Homo sapiens_hsa047403.67748021
5Vitamin B6 metabolism_Homo sapiens_hsa007503.43996538
6Pyruvate metabolism_Homo sapiens_hsa006203.34325183
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.21714804
8Linoleic acid metabolism_Homo sapiens_hsa005913.11776779
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.87406272
10Butanoate metabolism_Homo sapiens_hsa006502.80112065
11Glucagon signaling pathway_Homo sapiens_hsa049222.57763070
12Propanoate metabolism_Homo sapiens_hsa006402.45698219
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.45005084
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29959805
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.20370495
16Basal transcription factors_Homo sapiens_hsa030222.15867077
17Selenocompound metabolism_Homo sapiens_hsa004501.95032330
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.94441384
19Glycerolipid metabolism_Homo sapiens_hsa005611.93009911
20PPAR signaling pathway_Homo sapiens_hsa033201.89574642
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.72320816
22Fructose and mannose metabolism_Homo sapiens_hsa000511.70513546
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68849146
24Oocyte meiosis_Homo sapiens_hsa041141.57689655
25Mineral absorption_Homo sapiens_hsa049781.57370922
26Fat digestion and absorption_Homo sapiens_hsa049751.55516614
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55176786
28Arginine and proline metabolism_Homo sapiens_hsa003301.46997456
29Fatty acid metabolism_Homo sapiens_hsa012121.45991800
30Amphetamine addiction_Homo sapiens_hsa050311.45355011
31Fatty acid degradation_Homo sapiens_hsa000711.45031290
32Ether lipid metabolism_Homo sapiens_hsa005651.43096799
33Pentose phosphate pathway_Homo sapiens_hsa000301.41999558
34Type II diabetes mellitus_Homo sapiens_hsa049301.38840314
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.35284602
36Carbon metabolism_Homo sapiens_hsa012001.35223108
37Dorso-ventral axis formation_Homo sapiens_hsa043201.34080719
38Phototransduction_Homo sapiens_hsa047441.33540182
39Type I diabetes mellitus_Homo sapiens_hsa049401.25270942
40Cardiac muscle contraction_Homo sapiens_hsa042601.25069577
41Phenylalanine metabolism_Homo sapiens_hsa003601.19856935
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19580553
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.17942143
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17106780
45Antigen processing and presentation_Homo sapiens_hsa046121.13659475
46Autoimmune thyroid disease_Homo sapiens_hsa053201.13004437
47Allograft rejection_Homo sapiens_hsa053301.10295653
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07629745
49Fanconi anemia pathway_Homo sapiens_hsa034601.06174169
50Hedgehog signaling pathway_Homo sapiens_hsa043401.02652337
51Glutathione metabolism_Homo sapiens_hsa004801.02465041
52Graft-versus-host disease_Homo sapiens_hsa053321.01299807
53Renin secretion_Homo sapiens_hsa049240.99259641
54Purine metabolism_Homo sapiens_hsa002300.99199054
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99138372
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95957017
57Collecting duct acid secretion_Homo sapiens_hsa049660.92364394
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.90775727
59mRNA surveillance pathway_Homo sapiens_hsa030150.90625824
60Viral myocarditis_Homo sapiens_hsa054160.90387512
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.88515584
62Biosynthesis of amino acids_Homo sapiens_hsa012300.87552112
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86618255
64Arachidonic acid metabolism_Homo sapiens_hsa005900.86608918
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.86121488
66Nicotine addiction_Homo sapiens_hsa050330.85030556
67Nitrogen metabolism_Homo sapiens_hsa009100.84384363
68RNA transport_Homo sapiens_hsa030130.84052588
69Arginine biosynthesis_Homo sapiens_hsa002200.82003380
70Chemical carcinogenesis_Homo sapiens_hsa052040.80964169
71Insulin secretion_Homo sapiens_hsa049110.78715965
72Huntingtons disease_Homo sapiens_hsa050160.78546946
73Tight junction_Homo sapiens_hsa045300.77877659
74Thyroid hormone synthesis_Homo sapiens_hsa049180.77414170
75Estrogen signaling pathway_Homo sapiens_hsa049150.76531864
76Bile secretion_Homo sapiens_hsa049760.73623569
77Long-term potentiation_Homo sapiens_hsa047200.68958625
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68759003
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.68495306
80Morphine addiction_Homo sapiens_hsa050320.68297115
81Retinol metabolism_Homo sapiens_hsa008300.67844432
82Legionellosis_Homo sapiens_hsa051340.66478951
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57918535
84Systemic lupus erythematosus_Homo sapiens_hsa053220.57066643
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53518303
86Pancreatic secretion_Homo sapiens_hsa049720.52147689
87Protein digestion and absorption_Homo sapiens_hsa049740.51133711
88Renin-angiotensin system_Homo sapiens_hsa046140.50396974
89Tyrosine metabolism_Homo sapiens_hsa003500.50141268
90Glutamatergic synapse_Homo sapiens_hsa047240.49652872
91Endocytosis_Homo sapiens_hsa041440.49102736
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48690705
93Salivary secretion_Homo sapiens_hsa049700.48084159
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.46525073
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45806944
96AMPK signaling pathway_Homo sapiens_hsa041520.44729503
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43018709
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41800944
99Synaptic vesicle cycle_Homo sapiens_hsa047210.41430226
100Calcium signaling pathway_Homo sapiens_hsa040200.40854187
101VEGF signaling pathway_Homo sapiens_hsa043700.40710662
102Influenza A_Homo sapiens_hsa051640.38221973
103Gastric acid secretion_Homo sapiens_hsa049710.37990309
104MAPK signaling pathway_Homo sapiens_hsa040100.37588208
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36240162
106Pyrimidine metabolism_Homo sapiens_hsa002400.35775551
107ABC transporters_Homo sapiens_hsa020100.35685416
108Inositol phosphate metabolism_Homo sapiens_hsa005620.35227997
109Adherens junction_Homo sapiens_hsa045200.34395342
110Sulfur metabolism_Homo sapiens_hsa009200.34281083
111Metabolic pathways_Homo sapiens_hsa011000.34118111
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34112239
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34107897
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32912495
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32500861
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30903254
117Alcoholism_Homo sapiens_hsa050340.30676122
118Serotonergic synapse_Homo sapiens_hsa047260.30057030
119RNA polymerase_Homo sapiens_hsa030200.28947938
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28423303
121cAMP signaling pathway_Homo sapiens_hsa040240.27006000
122GABAergic synapse_Homo sapiens_hsa047270.22555156
123Base excision repair_Homo sapiens_hsa034100.22379591
124beta-Alanine metabolism_Homo sapiens_hsa004100.20537656
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20325209
126Cocaine addiction_Homo sapiens_hsa050300.19503899
127Mismatch repair_Homo sapiens_hsa034300.19412312
128Sulfur relay system_Homo sapiens_hsa041220.18855566
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18607588
130Taste transduction_Homo sapiens_hsa047420.18577234
131HIF-1 signaling pathway_Homo sapiens_hsa040660.18223676
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17762128
133Lysine degradation_Homo sapiens_hsa003100.17125948
134Cholinergic synapse_Homo sapiens_hsa047250.17107656
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16790538
136Circadian entrainment_Homo sapiens_hsa047130.16255614
137Basal cell carcinoma_Homo sapiens_hsa052170.14199222
138Wnt signaling pathway_Homo sapiens_hsa043100.11956576
139Salmonella infection_Homo sapiens_hsa051320.11149945
140Viral carcinogenesis_Homo sapiens_hsa052030.10974625
141B cell receptor signaling pathway_Homo sapiens_hsa046620.08080221
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03603288

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