FAM72C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.84600550
2mitotic sister chromatid segregation (GO:0000070)6.75839481
3sister chromatid segregation (GO:0000819)6.48786285
4protein localization to chromosome, centromeric region (GO:0071459)6.22526889
5nuclear pore complex assembly (GO:0051292)6.01543091
6protein localization to kinetochore (GO:0034501)5.93542601
7mitotic metaphase plate congression (GO:0007080)5.80435359
8DNA unwinding involved in DNA replication (GO:0006268)5.75469729
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.65969185
10nuclear pore organization (GO:0006999)5.32937461
11DNA topological change (GO:0006265)5.30645007
12kinetochore organization (GO:0051383)5.02299554
13regulation of mitotic spindle organization (GO:0060236)4.99249221
14regulation of spindle organization (GO:0090224)4.95707481
15metaphase plate congression (GO:0051310)4.95245690
16DNA strand elongation involved in DNA replication (GO:0006271)4.72941242
17mitotic nuclear envelope disassembly (GO:0007077)4.62667403
18DNA strand elongation (GO:0022616)4.60181397
19chromosome condensation (GO:0030261)4.49120488
20pore complex assembly (GO:0046931)4.42396260
21telomere maintenance via semi-conservative replication (GO:0032201)4.37904465
22establishment of chromosome localization (GO:0051303)4.36652816
23CENP-A containing nucleosome assembly (GO:0034080)4.34122013
24membrane disassembly (GO:0030397)4.32893049
25nuclear envelope disassembly (GO:0051081)4.32893049
26mitotic sister chromatid cohesion (GO:0007064)4.32799331
27DNA replication checkpoint (GO:0000076)4.32570674
28DNA ligation (GO:0006266)4.26176385
29chromosome segregation (GO:0007059)4.23899883
30regulation of chromosome segregation (GO:0051983)4.22757795
31meiotic chromosome segregation (GO:0045132)4.19980354
32positive regulation of chromosome segregation (GO:0051984)4.16003325
33protein localization to chromosome (GO:0034502)4.14764483
34chromatin remodeling at centromere (GO:0031055)4.12810500
35spindle checkpoint (GO:0031577)4.08824196
36kinetochore assembly (GO:0051382)4.08043985
37negative regulation of chromosome segregation (GO:0051985)4.05243121
38DNA replication initiation (GO:0006270)4.04783741
39regulation of translational fidelity (GO:0006450)3.99040478
40establishment of integrated proviral latency (GO:0075713)3.96022390
41microtubule depolymerization (GO:0007019)3.94708823
42mitotic spindle checkpoint (GO:0071174)3.93470847
43DNA packaging (GO:0006323)3.91901633
44mitotic recombination (GO:0006312)3.91417466
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.90320806
46negative regulation of sister chromatid segregation (GO:0033046)3.90320806
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.90320806
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.90320806
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.90320806
50mitotic spindle assembly checkpoint (GO:0007094)3.87925029
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85813142
52spindle assembly checkpoint (GO:0071173)3.85476470
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.82165620
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.82165620
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.82165620
56telomere maintenance via recombination (GO:0000722)3.79063107
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.79021484
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.79021484
59regulation of mitotic sister chromatid separation (GO:0010965)3.75789777
60regulation of mitotic sister chromatid segregation (GO:0033047)3.75789777
61regulation of sister chromatid segregation (GO:0033045)3.75789777
62formation of translation preinitiation complex (GO:0001731)3.70818993
63DNA replication-independent nucleosome organization (GO:0034724)3.68329005
64DNA replication-independent nucleosome assembly (GO:0006336)3.68329005
65attachment of spindle microtubules to kinetochore (GO:0008608)3.63037515
66regulation of centrosome cycle (GO:0046605)3.50411369
67histone exchange (GO:0043486)3.48048732
68regulation of sister chromatid cohesion (GO:0007063)3.42269518
69DNA conformation change (GO:0071103)3.41778129
70folic acid-containing compound biosynthetic process (GO:0009396)3.39869506
71DNA synthesis involved in DNA repair (GO:0000731)3.38624349
72nuclear envelope organization (GO:0006998)3.37398202
73regulation of centriole replication (GO:0046599)3.31911492
74chromatin assembly or disassembly (GO:0006333)3.24432091
75DNA duplex unwinding (GO:0032508)3.19499008
76regulation of RNA export from nucleus (GO:0046831)3.17474011
77heterochromatin organization (GO:0070828)3.17070152
78ribosomal small subunit biogenesis (GO:0042274)3.16914347
79ATP-dependent chromatin remodeling (GO:0043044)3.14597731
80synapsis (GO:0007129)3.13739677
81mitotic cell cycle (GO:0000278)3.13246220
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.12912379
83IMP biosynthetic process (GO:0006188)3.10082603
84regulation of DNA endoreduplication (GO:0032875)3.09161279
85DNA geometric change (GO:0032392)3.09107054
86negative regulation of mitosis (GO:0045839)3.04316736
87purine nucleobase biosynthetic process (GO:0009113)3.03707909
88telomere maintenance via telomere lengthening (GO:0010833)3.03176192
89chromosome organization (GO:0051276)3.02934008
90establishment of mitotic spindle localization (GO:0040001)2.97680815
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95933906
92mitotic G2/M transition checkpoint (GO:0044818)2.94962311
93establishment of viral latency (GO:0019043)2.93587594
94regulation of histone H3-K9 methylation (GO:0051570)2.92291190
95spindle organization (GO:0007051)2.92000294
96ribosome biogenesis (GO:0042254)2.90182799
97ribonucleoprotein complex biogenesis (GO:0022613)2.89623772
98negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.89100194
99nucleobase biosynthetic process (GO:0046112)2.88342648
100ribosome assembly (GO:0042255)2.86605965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.06627171
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.26355002
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.64941515
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.52892175
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.92485647
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37213889
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26431494
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15375217
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14030423
10AR_21909140_ChIP-Seq_LNCAP_Human3.06455232
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76108970
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66057379
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64169496
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60894295
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.36642774
16XRN2_22483619_ChIP-Seq_HELA_Human2.34490014
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.25696993
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24456402
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.22888251
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15815959
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15339656
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.12684876
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12268768
24DCP1A_22483619_ChIP-Seq_HELA_Human2.07983330
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07572861
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05913793
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02209036
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.97751741
29TTF2_22483619_ChIP-Seq_HELA_Human1.93217483
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88787138
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85397745
32MYC_22102868_ChIP-Seq_BL_Human1.82308942
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77032097
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76759696
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75286017
36FOXP3_21729870_ChIP-Seq_TREG_Human1.71675989
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66991361
38GABP_19822575_ChIP-Seq_HepG2_Human1.54614657
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53990751
40ELK1_19687146_ChIP-ChIP_HELA_Human1.53770110
41KDM5A_27292631_Chip-Seq_BREAST_Human1.52670809
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51695421
43VDR_23849224_ChIP-Seq_CD4+_Human1.48529278
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45365017
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44800433
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44685205
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43975050
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.41462759
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38014507
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38005939
51CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37774085
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37699780
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36100777
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34365153
55CIITA_25753668_ChIP-Seq_RAJI_Human1.29868436
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29541721
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28563003
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24625458
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24013010
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19346622
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18915818
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17364909
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17130038
64ZNF263_19887448_ChIP-Seq_K562_Human1.14709499
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09269110
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.07631483
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07258969
68TFEB_21752829_ChIP-Seq_HELA_Human1.03478007
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.02266659
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02080798
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00705825
72NCOR1_26117541_ChIP-Seq_K562_Human1.00096420
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99092271
74VDR_21846776_ChIP-Seq_THP-1_Human0.98755083
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96810438
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96178691
77CHD1_26751641_Chip-Seq_LNCaP_Human0.93159507
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92810966
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92127043
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91122395
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.87401162
82NANOG_21062744_ChIP-ChIP_HESCs_Human0.86688612
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85824240
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84768865
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83839507
86MYC_18940864_ChIP-ChIP_HL60_Human0.83370882
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.83199778
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80748643
89SALL1_21062744_ChIP-ChIP_HESCs_Human0.80302783
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80054350
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79985289
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79181705
93GATA1_22025678_ChIP-Seq_K562_Human0.77809554
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74675253
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74360843
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73649245
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72879655
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72855873
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72705932
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72571658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61120846
2MP0010094_abnormal_chromosome_stability5.48792617
3MP0003111_abnormal_nucleus_morphology5.45551993
4MP0004957_abnormal_blastocyst_morpholog4.60173537
5MP0003077_abnormal_cell_cycle4.39115830
6MP0008057_abnormal_DNA_replication4.04036485
7MP0008058_abnormal_DNA_repair3.79164634
8MP0008932_abnormal_embryonic_tissue3.20637016
9MP0008007_abnormal_cellular_replicative2.93498281
10MP0001730_embryonic_growth_arrest2.43381947
11MP0000350_abnormal_cell_proliferation2.36361158
12MP0010307_abnormal_tumor_latency2.28074243
13MP0003718_maternal_effect2.18066880
14MP0002396_abnormal_hematopoietic_system1.99846798
15MP0003786_premature_aging1.99202793
16MP0001697_abnormal_embryo_size1.97320550
17MP0005380_embryogenesis_phenotype1.93060523
18MP0001672_abnormal_embryogenesis/_devel1.93060523
19MP0009697_abnormal_copulation1.92942533
20MP0002877_abnormal_melanocyte_morpholog1.92111168
21MP0005076_abnormal_cell_differentiation1.87795636
22MP0002080_prenatal_lethality1.79377417
23MP0000313_abnormal_cell_death1.76509162
24MP0003984_embryonic_growth_retardation1.69859717
25MP0002088_abnormal_embryonic_growth/wei1.62344607
26MP0003656_abnormal_erythrocyte_physiolo1.61423013
27MP0004147_increased_porphyrin_level1.59868139
28MP0002085_abnormal_embryonic_tissue1.53118912
29MP0005451_abnormal_body_composition1.50117330
30MP0010352_gastrointestinal_tract_polyps1.39425540
31MP0002210_abnormal_sex_determination1.38933003
32MP0002084_abnormal_developmental_patter1.38175076
33MP0002086_abnormal_extraembryonic_tissu1.35988020
34MP0003890_abnormal_embryonic-extraembry1.33926700
35MP0009672_abnormal_birth_weight1.33198545
36MP0004185_abnormal_adipocyte_glucose1.32498502
37MP0004808_abnormal_hematopoietic_stem1.29797528
38MP0002019_abnormal_tumor_incidence1.29512735
39MP0001661_extended_life_span1.27949019
40MP0008995_early_reproductive_senescence1.27413623
41MP0004233_abnormal_muscle_weight1.26582740
42MP0003705_abnormal_hypodermis_morpholog1.25963202
43MP0004197_abnormal_fetal_growth/weight/1.24935697
44MP0001929_abnormal_gametogenesis1.24160094
45MP0006035_abnormal_mitochondrial_morpho1.19703766
46MP0002009_preneoplasia1.18574321
47MP0000358_abnormal_cell_content/1.10628473
48MP0001145_abnormal_male_reproductive1.07160963
49MP0000490_abnormal_crypts_of1.05213748
50MP0006292_abnormal_olfactory_placode1.03443695
51MP0005501_abnormal_skin_physiology0.98779719
52MP0003937_abnormal_limbs/digits/tail_de0.93424170
53MP0000653_abnormal_sex_gland0.92443886
54MP0003699_abnormal_female_reproductive0.90336087
55MP0003221_abnormal_cardiomyocyte_apopto0.89971246
56MP0005384_cellular_phenotype0.89918710
57MP0005621_abnormal_cell_physiology0.89769630
58MP0002697_abnormal_eye_size0.89659768
59MP0000678_abnormal_parathyroid_gland0.88355716
60MP0000703_abnormal_thymus_morphology0.86316505
61MP0003950_abnormal_plasma_membrane0.86240701
62MP0003941_abnormal_skin_development0.85553251
63MP0006036_abnormal_mitochondrial_physio0.85396304
64MP0005083_abnormal_biliary_tract0.83391148
65MP0008877_abnormal_DNA_methylation0.83088021
66MP0003806_abnormal_nucleotide_metabolis0.79487644
67MP0001727_abnormal_embryo_implantation0.78460152
68MP0010030_abnormal_orbit_morphology0.77937511
69MP0001286_abnormal_eye_development0.77849876
70MP0009703_decreased_birth_body0.75834940
71MP0002111_abnormal_tail_morphology0.75318805
72MP0002161_abnormal_fertility/fecundity0.75038195
73MP0000428_abnormal_craniofacial_morphol0.73322276
74MP0003698_abnormal_male_reproductive0.72845701
75MP0001293_anophthalmia0.71144737
76MP0010234_abnormal_vibrissa_follicle0.70511970
77MP0001881_abnormal_mammary_gland0.69431632
78MP0003315_abnormal_perineum_morphology0.69157129
79MP0001346_abnormal_lacrimal_gland0.66788937
80MP0001119_abnormal_female_reproductive0.66278689
81MP0003186_abnormal_redox_activity0.66246127
82MP0003567_abnormal_fetal_cardiomyocyte0.64225179
83MP0003123_paternal_imprinting0.62526113
84MP0001545_abnormal_hematopoietic_system0.60771421
85MP0005397_hematopoietic_system_phenotyp0.60771421
86MP0002796_impaired_skin_barrier0.59436757
87MP0002398_abnormal_bone_marrow0.58864757
88MP0002722_abnormal_immune_system0.58533352
89MP0003861_abnormal_nervous_system0.58244270
90MP0002163_abnormal_gland_morphology0.58212074
91MP0003385_abnormal_body_wall0.57413889
92MP0002269_muscular_atrophy0.57143311
93MP0009379_abnormal_foot_pigmentation0.56816954
94MP0002160_abnormal_reproductive_system0.56537996
95MP0002970_abnormal_white_adipose0.56250173
96MP0005666_abnormal_adipose_tissue0.54947955
97MP0005395_other_phenotype0.54168765
98MP0001529_abnormal_vocalization0.53522416
99MP0009333_abnormal_splenocyte_physiolog0.52748890
100MP0002092_abnormal_eye_morphology0.50309495

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.31341612
2Chromsome breakage (HP:0040012)6.02745094
3Increased nuchal translucency (HP:0010880)4.16778683
4Reticulocytopenia (HP:0001896)3.95214488
5Cortical dysplasia (HP:0002539)3.93856724
6Abnormality of the preputium (HP:0100587)3.68296174
7Birth length less than 3rd percentile (HP:0003561)3.60292798
8Small intestinal stenosis (HP:0012848)3.53835988
9Duodenal stenosis (HP:0100867)3.53835988
10Abnormality of chromosome stability (HP:0003220)3.52509114
11Meckel diverticulum (HP:0002245)3.47905194
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.46713056
13Myelodysplasia (HP:0002863)3.36182743
14Nephroblastoma (Wilms tumor) (HP:0002667)3.33290545
15Cholecystitis (HP:0001082)3.28732761
16Abnormal gallbladder physiology (HP:0012438)3.28732761
17Abnormality of the ileum (HP:0001549)3.28009002
18Embryonal renal neoplasm (HP:0011794)3.13274101
19Abnormal lung lobation (HP:0002101)3.12259739
20Abnormality of reticulocytes (HP:0004312)3.09980994
21Abnormality of cells of the erythroid lineage (HP:0012130)2.96742320
22Abnormality of the duodenum (HP:0002246)2.88039179
23Abnormality of the carotid arteries (HP:0005344)2.73167326
24Reticulocytosis (HP:0001923)2.69607233
25Progressive muscle weakness (HP:0003323)2.68102621
26Progressive external ophthalmoplegia (HP:0000590)2.66372744
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62231405
28Cafe-au-lait spot (HP:0000957)2.61316979
29Pallor (HP:0000980)2.58462189
30Volvulus (HP:0002580)2.55156790
31Overlapping toe (HP:0001845)2.49153715
32Multiple enchondromatosis (HP:0005701)2.46395286
33Abnormal number of erythroid precursors (HP:0012131)2.46213931
34Microvesicular hepatic steatosis (HP:0001414)2.44889965
35Ankyloglossia (HP:0010296)2.44060361
36Horseshoe kidney (HP:0000085)2.43328487
37Squamous cell carcinoma (HP:0002860)2.42814560
38Duplicated collecting system (HP:0000081)2.36871414
39Sloping forehead (HP:0000340)2.35060273
40Abnormality of glycolysis (HP:0004366)2.33581429
41Abnormality of cochlea (HP:0000375)2.29757104
4211 pairs of ribs (HP:0000878)2.29324944
43Breast hypoplasia (HP:0003187)2.29038486
44Absent radius (HP:0003974)2.28240858
45Abnormality of chromosome segregation (HP:0002916)2.26387603
46Ectopic kidney (HP:0000086)2.24329109
47Absent thumb (HP:0009777)2.22396138
48Macrocytic anemia (HP:0001972)2.20686154
49Embryonal neoplasm (HP:0002898)2.20198803
50Missing ribs (HP:0000921)2.19345152
51Choanal atresia (HP:0000453)2.18448407
52Increased serum pyruvate (HP:0003542)2.18351810
53Acute myeloid leukemia (HP:0004808)2.17063065
54Abnormality of DNA repair (HP:0003254)2.16049689
55Proximal placement of thumb (HP:0009623)2.15623503
56Deep philtrum (HP:0002002)2.14426506
57Aplasia involving forearm bones (HP:0009822)2.09837600
58Absent forearm bone (HP:0003953)2.09837600
59Insomnia (HP:0100785)2.09131741
60Medulloblastoma (HP:0002885)2.05365914
61Facial hemangioma (HP:0000329)2.04620582
62Deviation of the thumb (HP:0009603)2.04477491
63Arteriovenous malformation (HP:0100026)2.03540045
64Duplication of thumb phalanx (HP:0009942)2.03002911
65Triphalangeal thumb (HP:0001199)1.97395201
66Truncus arteriosus (HP:0001660)1.96993667
67Abnormality of the renal collecting system (HP:0004742)1.95937253
68Clubbing of toes (HP:0100760)1.93995766
69Cholelithiasis (HP:0001081)1.91888273
70Short thumb (HP:0009778)1.91139368
71Neoplasm of the colon (HP:0100273)1.90806298
72Sandal gap (HP:0001852)1.88340617
73Rhabdomyosarcoma (HP:0002859)1.86507116
74Upper limb muscle weakness (HP:0003484)1.85367083
75Poikiloderma (HP:0001029)1.83627121
76Bone marrow hypocellularity (HP:0005528)1.83129297
77Orthostatic hypotension (HP:0001278)1.81739172
78Nonimmune hydrops fetalis (HP:0001790)1.79109859
79Abnormality of the heme biosynthetic pathway (HP:0010472)1.79020223
80Premature ovarian failure (HP:0008209)1.78951704
81Patellar aplasia (HP:0006443)1.77572183
82Abnormality of oral frenula (HP:0000190)1.77272611
83Ureteral duplication (HP:0000073)1.77136768
84Obsessive-compulsive behavior (HP:0000722)1.76398359
85Abnormality of homocysteine metabolism (HP:0010919)1.70580748
86Homocystinuria (HP:0002156)1.70580748
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70504692
88Aplasia/Hypoplasia of the patella (HP:0006498)1.70420824
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69121920
90Atresia of the external auditory canal (HP:0000413)1.68622009
91Short middle phalanx of the 5th finger (HP:0004220)1.68038790
92Poikilocytosis (HP:0004447)1.67972111
93Impulsivity (HP:0100710)1.66370803
94Hypergonadotropic hypogonadism (HP:0000815)1.66211078
95Pancytopenia (HP:0001876)1.65383171
96Abnormal gallbladder morphology (HP:0012437)1.64614252
97Heterotopia (HP:0002282)1.63400062
98Selective tooth agenesis (HP:0001592)1.62346012
99Carpal bone hypoplasia (HP:0001498)1.62062795
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.61804788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.83563444
2TTK4.25911015
3CDC73.80441393
4NEK13.66107466
5PBK3.11422739
6WEE13.03112061
7EIF2AK12.98301508
8SRPK12.74261535
9BRSK22.56661158
10NEK22.53574345
11PLK42.48083531
12CDK122.07246231
13PLK31.96755432
14CHEK21.88515097
15BRSK11.86698263
16PLK11.82621605
17TSSK61.78647383
18MAP3K101.70045156
19CCNB11.68814462
20AURKB1.59062055
21NME21.58514573
22BRAF1.57294566
23VRK21.56548498
24EEF2K1.56158030
25MAP3K81.54635416
26SMG11.49873866
27ATR1.43836763
28EIF2AK31.36463676
29ICK1.34550997
30AURKA1.31933648
31CLK11.31219674
32CHEK11.30939721
33CDK71.29151165
34STK101.25339203
35ZAK1.24308042
36CDK41.21472727
37SCYL21.21175121
38STK41.18628790
39CDK81.15206580
40VRK11.15010698
41MKNK11.14495700
42PRPF4B1.12511961
43RPS6KB21.09336218
44TAF11.01644448
45BRD41.01563571
46IRAK30.98334736
47KSR20.96695389
48ATM0.88950275
49CDK10.84978776
50RAF10.81443991
51EIF2AK20.81031956
52CDK20.78122707
53PASK0.74659664
54MKNK20.74637537
55MST1R0.72458275
56STK30.69456090
57MST40.67851505
58LATS20.66704726
59NME10.62774934
60STK160.61637444
61ALK0.61220200
62CDK60.57894412
63MAP3K90.57473999
64MET0.53960127
65PAK10.52234117
66RPS6KA40.51782073
67PNCK0.49395900
68MARK30.49245524
69KSR10.48944001
70ERBB40.47671788
71CSNK2A20.47340773
72MTOR0.47286254
73CDK11A0.47127302
74DYRK30.45232517
75TRIB30.44915206
76CDK150.44615473
77BMX0.44456924
78MAP3K130.44278861
79TESK20.44213313
80PDK20.43950522
81PAK40.43839480
82CSNK2A10.43183571
83MELK0.43066893
84CDK90.42667778
85AKT20.42392573
86CDK180.41925399
87ARAF0.41452435
88TAOK20.40884988
89CDK140.34303789
90CSNK1E0.33757973
91MAPK110.32648051
92NEK90.32559139
93PRKDC0.30526404
94PIM10.29721396
95MAPK140.28314997
96GSK3B0.23489761
97DMPK0.22541593
98PRKCI0.21972933
99CDK30.21077839
100RPS6KA50.17619219

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.93836520
2Mismatch repair_Homo sapiens_hsa034304.27983494
3Cell cycle_Homo sapiens_hsa041103.55302358
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.38137418
5Homologous recombination_Homo sapiens_hsa034403.15757536
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99796901
7Spliceosome_Homo sapiens_hsa030402.92950089
8Base excision repair_Homo sapiens_hsa034102.90452001
9RNA transport_Homo sapiens_hsa030132.81459638
10Nucleotide excision repair_Homo sapiens_hsa034202.75430379
11One carbon pool by folate_Homo sapiens_hsa006702.71660479
12Ribosome_Homo sapiens_hsa030102.66128265
13Non-homologous end-joining_Homo sapiens_hsa034502.61934239
14Fanconi anemia pathway_Homo sapiens_hsa034602.60314310
15mRNA surveillance pathway_Homo sapiens_hsa030151.93800578
16Basal transcription factors_Homo sapiens_hsa030221.80787172
17Pyrimidine metabolism_Homo sapiens_hsa002401.76212909
18Proteasome_Homo sapiens_hsa030501.73405643
19RNA polymerase_Homo sapiens_hsa030201.73041361
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65844676
21Oocyte meiosis_Homo sapiens_hsa041141.57270585
22Biosynthesis of amino acids_Homo sapiens_hsa012301.56700335
23RNA degradation_Homo sapiens_hsa030181.49401335
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46961668
25p53 signaling pathway_Homo sapiens_hsa041151.38008592
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.20442853
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18536065
28Carbon metabolism_Homo sapiens_hsa012001.14926931
29Pyruvate metabolism_Homo sapiens_hsa006201.10439824
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08140143
31Thyroid cancer_Homo sapiens_hsa052161.05232391
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05133397
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03765189
34Selenocompound metabolism_Homo sapiens_hsa004501.02607778
35Pentose phosphate pathway_Homo sapiens_hsa000301.01485395
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01115057
37Viral carcinogenesis_Homo sapiens_hsa052031.00737793
38Purine metabolism_Homo sapiens_hsa002300.99738903
39Chronic myeloid leukemia_Homo sapiens_hsa052200.94498641
40MicroRNAs in cancer_Homo sapiens_hsa052060.88333673
41Folate biosynthesis_Homo sapiens_hsa007900.88191048
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87995210
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83049661
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.81503300
45Protein export_Homo sapiens_hsa030600.77991929
46N-Glycan biosynthesis_Homo sapiens_hsa005100.76354423
47Steroid biosynthesis_Homo sapiens_hsa001000.75628074
48Epstein-Barr virus infection_Homo sapiens_hsa051690.74721611
49Pancreatic cancer_Homo sapiens_hsa052120.73736067
50Bladder cancer_Homo sapiens_hsa052190.71061838
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69847906
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67621225
53Small cell lung cancer_Homo sapiens_hsa052220.65932736
54Vitamin B6 metabolism_Homo sapiens_hsa007500.64610210
55Non-small cell lung cancer_Homo sapiens_hsa052230.64384791
56HTLV-I infection_Homo sapiens_hsa051660.64255906
57Sulfur relay system_Homo sapiens_hsa041220.58591163
58Systemic lupus erythematosus_Homo sapiens_hsa053220.58278518
59Lysine degradation_Homo sapiens_hsa003100.57212773
60Fructose and mannose metabolism_Homo sapiens_hsa000510.55376916
61Alcoholism_Homo sapiens_hsa050340.54735044
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53549121
63Acute myeloid leukemia_Homo sapiens_hsa052210.50904512
64Huntingtons disease_Homo sapiens_hsa050160.50881296
65Hepatitis B_Homo sapiens_hsa051610.49549623
66Colorectal cancer_Homo sapiens_hsa052100.48308215
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46793405
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45807504
69Herpes simplex infection_Homo sapiens_hsa051680.45278971
70Apoptosis_Homo sapiens_hsa042100.43688675
71Prostate cancer_Homo sapiens_hsa052150.43143493
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42215229
73Fatty acid elongation_Homo sapiens_hsa000620.38778888
74Renal cell carcinoma_Homo sapiens_hsa052110.37235529
75Glutathione metabolism_Homo sapiens_hsa004800.35807097
76Parkinsons disease_Homo sapiens_hsa050120.34948440
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33256798
78mTOR signaling pathway_Homo sapiens_hsa041500.30876864
79Shigellosis_Homo sapiens_hsa051310.30495227
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27479363
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26845847
82Glioma_Homo sapiens_hsa052140.26273494
83Adherens junction_Homo sapiens_hsa045200.26240174
84HIF-1 signaling pathway_Homo sapiens_hsa040660.26093632
85Metabolic pathways_Homo sapiens_hsa011000.22476928
86Galactose metabolism_Homo sapiens_hsa000520.22124263
87ErbB signaling pathway_Homo sapiens_hsa040120.19039833
88Propanoate metabolism_Homo sapiens_hsa006400.18278794
89Endometrial cancer_Homo sapiens_hsa052130.17923063
90Insulin signaling pathway_Homo sapiens_hsa049100.17881797
91B cell receptor signaling pathway_Homo sapiens_hsa046620.16229822
92Melanoma_Homo sapiens_hsa052180.15916681
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.15675117
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15461244
95Wnt signaling pathway_Homo sapiens_hsa043100.13632989
96TGF-beta signaling pathway_Homo sapiens_hsa043500.13492179
97Hippo signaling pathway_Homo sapiens_hsa043900.13081172
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12769002
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12008196
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11208348

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