FAM78B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60899463
2vocalization behavior (GO:0071625)5.35646264
3neuron cell-cell adhesion (GO:0007158)5.23331176
4synaptic vesicle maturation (GO:0016188)5.13006182
5synaptic vesicle exocytosis (GO:0016079)5.06839523
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06827665
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97022761
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94618855
9protein localization to synapse (GO:0035418)4.91540035
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.90558592
11locomotory exploration behavior (GO:0035641)4.81977788
12regulation of synaptic vesicle exocytosis (GO:2000300)4.73132431
13glutamate secretion (GO:0014047)4.51893743
14regulation of glutamate receptor signaling pathway (GO:1900449)4.39835236
15behavioral response to nicotine (GO:0035095)4.26444807
16layer formation in cerebral cortex (GO:0021819)4.24864372
17cell migration in hindbrain (GO:0021535)4.20505904
18regulation of synaptic vesicle transport (GO:1902803)4.10088118
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.08527804
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.06361056
21exploration behavior (GO:0035640)3.97035074
22postsynaptic membrane organization (GO:0001941)3.94528911
23neurotransmitter secretion (GO:0007269)3.92914588
24regulation of synapse structural plasticity (GO:0051823)3.86051136
25neuron recognition (GO:0008038)3.82714156
26glutamate receptor signaling pathway (GO:0007215)3.79812964
27innervation (GO:0060384)3.77575165
28synaptic transmission, glutamatergic (GO:0035249)3.76997829
29positive regulation of synapse maturation (GO:0090129)3.76225335
30neuronal action potential propagation (GO:0019227)3.75636493
31neuromuscular synaptic transmission (GO:0007274)3.71718228
32axonal fasciculation (GO:0007413)3.69348292
33neuron-neuron synaptic transmission (GO:0007270)3.63529061
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59278496
35dendritic spine morphogenesis (GO:0060997)3.58179030
36dendrite morphogenesis (GO:0048813)3.55527168
37regulation of neuronal synaptic plasticity (GO:0048168)3.54129602
38neurotransmitter-gated ion channel clustering (GO:0072578)3.49655811
39cerebellar Purkinje cell differentiation (GO:0021702)3.49197184
40proline transport (GO:0015824)3.48890693
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47771759
42nucleobase catabolic process (GO:0046113)3.47624366
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45423280
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40470112
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39208909
46synapse assembly (GO:0007416)3.36399019
47regulation of neurotransmitter secretion (GO:0046928)3.35563620
48regulation of postsynaptic membrane potential (GO:0060078)3.35217979
49central nervous system projection neuron axonogenesis (GO:0021952)3.34135641
50positive regulation of membrane potential (GO:0045838)3.33451722
51auditory behavior (GO:0031223)3.31232001
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.28705989
53gamma-aminobutyric acid transport (GO:0015812)3.28222318
54cellular potassium ion homeostasis (GO:0030007)3.26387884
55synaptic vesicle endocytosis (GO:0048488)3.25117123
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24527916
57long-term memory (GO:0007616)3.21996365
58neurotransmitter transport (GO:0006836)3.21950916
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17987832
60presynaptic membrane assembly (GO:0097105)3.17095691
61regulation of synapse maturation (GO:0090128)3.15957865
62pyrimidine nucleobase catabolic process (GO:0006208)3.15681855
63membrane hyperpolarization (GO:0060081)3.15087872
64regulation of neurotransmitter transport (GO:0051588)3.15015247
65cerebellar granule cell differentiation (GO:0021707)3.10211679
66regulation of dendritic spine morphogenesis (GO:0061001)3.07740872
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.07666474
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07506205
69response to histamine (GO:0034776)3.05850724
70neuronal ion channel clustering (GO:0045161)3.05409967
71membrane depolarization during action potential (GO:0086010)3.02126992
72righting reflex (GO:0060013)3.01538905
73sodium ion export (GO:0071436)3.01182150
74positive regulation of neurotransmitter transport (GO:0051590)3.00136982
75response to auditory stimulus (GO:0010996)3.00055462
76neuromuscular process controlling balance (GO:0050885)2.98888495
77regulation of synaptic plasticity (GO:0048167)2.98515897
78synaptic transmission, cholinergic (GO:0007271)2.98429996
79negative regulation of dendrite development (GO:2000171)2.97597675
80positive regulation of meiosis (GO:0045836)2.97337149
81positive regulation of neurotransmitter secretion (GO:0001956)2.96945230
82long-term synaptic potentiation (GO:0060291)2.96887296
83synapse organization (GO:0050808)2.95666981
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95407137
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.94234343
86mechanosensory behavior (GO:0007638)2.93483813
87cochlea development (GO:0090102)2.93417518
88transmission of nerve impulse (GO:0019226)2.92690944
89regulation of neurotransmitter levels (GO:0001505)2.92293977
90regulation of dendritic spine development (GO:0060998)2.91869843
91membrane depolarization (GO:0051899)2.91702153
92regulation of voltage-gated calcium channel activity (GO:1901385)2.91524448
93regulation of calcium ion-dependent exocytosis (GO:0017158)2.91336859
94regulation of respiratory system process (GO:0044065)2.90536329
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90200427
96presynaptic membrane organization (GO:0097090)2.89928163
97positive regulation of dendritic spine development (GO:0060999)2.89554127
98startle response (GO:0001964)2.87984313
99detection of calcium ion (GO:0005513)2.87548437
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87062878
101short-term memory (GO:0007614)2.86371955
102activation of protein kinase A activity (GO:0034199)2.86242352
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85863547
104response to pheromone (GO:0019236)2.84858920
105axon extension (GO:0048675)2.84809976
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84265371
107prepulse inhibition (GO:0060134)2.84078769
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83439003
109organelle transport along microtubule (GO:0072384)2.83028816
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82925937
111cell communication by electrical coupling (GO:0010644)2.82459548
112learning (GO:0007612)2.82002900
113central nervous system neuron axonogenesis (GO:0021955)2.79800466
114suckling behavior (GO:0001967)2.78525336
115cerebral cortex radially oriented cell migration (GO:0021799)2.78085037
116regulation of vesicle fusion (GO:0031338)2.77416852
117positive regulation of synapse assembly (GO:0051965)2.76963736
118negative regulation of microtubule polymerization (GO:0031115)2.76629691
119vesicle transport along microtubule (GO:0047496)2.76362758
120dopamine receptor signaling pathway (GO:0007212)2.75888431
121positive regulation of meiotic cell cycle (GO:0051446)2.72720484
122behavioral response to ethanol (GO:0048149)2.69998212
123serotonin metabolic process (GO:0042428)2.67964205
124tachykinin receptor signaling pathway (GO:0007217)2.67336130
125behavioral defense response (GO:0002209)2.66875337
126behavioral fear response (GO:0001662)2.66875337
127neuronal action potential (GO:0019228)2.66113534
128potassium ion import (GO:0010107)2.66035747
129C4-dicarboxylate transport (GO:0015740)2.65145960
130fear response (GO:0042596)2.63683869
131multicellular organismal signaling (GO:0035637)2.63182992
132negative regulation of neurotransmitter transport (GO:0051589)2.62785680
133regulation of neurotransmitter uptake (GO:0051580)2.59015994
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.56497979
135synaptic transmission (GO:0007268)2.55618453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73844471
2GBX2_23144817_ChIP-Seq_PC3_Human3.42440468
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02579078
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96664043
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93413967
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74060619
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74060619
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.61714076
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61387473
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50365094
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49919042
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.49649493
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44472565
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39457658
15DROSHA_22980978_ChIP-Seq_HELA_Human2.37641304
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37233202
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26414343
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.25541655
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21264724
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20529377
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20301481
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19394846
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.10038284
24VDR_22108803_ChIP-Seq_LS180_Human2.09014336
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.98144928
26AR_21572438_ChIP-Seq_LNCaP_Human1.91148910
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85540190
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75876648
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75500021
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75182182
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71669067
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69491650
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65570887
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.62469758
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60565014
36TAF15_26573619_Chip-Seq_HEK293_Human1.60342325
37IGF1R_20145208_ChIP-Seq_DFB_Human1.59261193
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58882049
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57911089
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54226300
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.50198451
42ZNF274_21170338_ChIP-Seq_K562_Hela1.50154444
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.49708866
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.43947003
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43739490
46P300_19829295_ChIP-Seq_ESCs_Human1.43641315
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43461218
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40888315
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36915281
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35579479
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.34877951
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.34503427
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32278292
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.32114244
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31946642
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.29211588
57* AR_25329375_ChIP-Seq_VCAP_Human1.27835672
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27770691
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27084779
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26019334
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25776759
62RNF2_27304074_Chip-Seq_NSC_Mouse1.24950195
63BCAT_22108803_ChIP-Seq_LS180_Human1.24516621
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.23791561
65AHR_22903824_ChIP-Seq_MCF-7_Human1.23091164
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23027355
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22928633
68AR_19668381_ChIP-Seq_PC3_Human1.22573590
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20423153
70STAT3_23295773_ChIP-Seq_U87_Human1.19094641
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18509899
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18396846
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18199294
74* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15925037
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15385783
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14822259
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13892652
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12936719
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12734334
80CBP_20019798_ChIP-Seq_JUKART_Human1.12523403
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12523403
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11337163
83* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11327897
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10914961
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09840517
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08767859
87* TCF4_23295773_ChIP-Seq_U87_Human1.08048602
88* KDM2B_26808549_Chip-Seq_K562_Human1.07290150
89* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06602704
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06075263
91* P53_22387025_ChIP-Seq_ESCs_Mouse1.05237192
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04915978
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04228503
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03429665
95RUNX2_22187159_ChIP-Seq_PCA_Human1.03142944
96* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02469644
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01957156
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01876188
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00489210
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.00457512
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00359151
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00007177
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99689959
104SOX9_26525672_Chip-Seq_HEART_Mouse0.99128814
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98238234
106FLI1_21867929_ChIP-Seq_TH2_Mouse0.98152394
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97997469
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.97510038
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97443556
110TCF4_22108803_ChIP-Seq_LS180_Human0.97012691
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.96528592
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96517522
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96517522
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.95719103
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95632250
116EWS_26573619_Chip-Seq_HEK293_Human0.95180298
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94590213
118* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93969293
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93161228
120* JUN_21703547_ChIP-Seq_K562_Human0.88690671
121FUS_26573619_Chip-Seq_HEK293_Human0.88254163
122ER_23166858_ChIP-Seq_MCF-7_Human0.88198638
123* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87728372
124TP53_16413492_ChIP-PET_HCT116_Human0.87024821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43046824
2MP0003880_abnormal_central_pattern3.99865758
3MP0003635_abnormal_synaptic_transmissio3.69091611
4MP0004270_analgesia3.56675878
5MP0005423_abnormal_somatic_nervous3.07654766
6MP0002063_abnormal_learning/memory/cond3.00446172
7MP0001968_abnormal_touch/_nociception2.94507866
8MP0009745_abnormal_behavioral_response2.90352273
9MP0009046_muscle_twitch2.88046772
10MP0002064_seizures2.72568660
11MP0000569_abnormal_digit_pigmentation2.66730874
12MP0002734_abnormal_mechanical_nocicepti2.63591151
13MP0002572_abnormal_emotion/affect_behav2.55502019
14MP0002735_abnormal_chemical_nociception2.47059444
15MP0002822_catalepsy2.38621883
16MP0002184_abnormal_innervation2.37616394
17MP0004858_abnormal_nervous_system2.33180218
18MP0001486_abnormal_startle_reflex2.32127676
19MP0000778_abnormal_nervous_system2.31990571
20MP0002736_abnormal_nociception_after2.26515361
21MP0002272_abnormal_nervous_system2.19177261
22MP0001440_abnormal_grooming_behavior1.93876997
23MP0006276_abnormal_autonomic_nervous1.93864036
24MP0002067_abnormal_sensory_capabilities1.93505730
25MP0002733_abnormal_thermal_nociception1.91856011
26MP0004811_abnormal_neuron_physiology1.87727489
27MP0005551_abnormal_eye_electrophysiolog1.86195171
28MP0001970_abnormal_pain_threshold1.84268672
29MP0009780_abnormal_chondrocyte_physiolo1.80029387
30MP0001188_hyperpigmentation1.79848842
31MP0001501_abnormal_sleep_pattern1.78978086
32MP0002557_abnormal_social/conspecific_i1.77637679
33MP0001984_abnormal_olfaction1.73188325
34MP0004924_abnormal_behavior1.70785409
35MP0005386_behavior/neurological_phenoty1.70785409
36MP0008569_lethality_at_weaning1.69684667
37MP0005645_abnormal_hypothalamus_physiol1.65938837
38MP0000955_abnormal_spinal_cord1.64249805
39MP0002882_abnormal_neuron_morphology1.63898364
40MP0008877_abnormal_DNA_methylation1.53946558
41MP0001502_abnormal_circadian_rhythm1.52243816
42MP0003787_abnormal_imprinting1.51730959
43MP0002909_abnormal_adrenal_gland1.51308706
44MP0002638_abnormal_pupillary_reflex1.44257503
45MP0004885_abnormal_endolymph1.41065446
46MP0003122_maternal_imprinting1.41014104
47MP0000372_irregular_coat_pigmentation1.35901511
48MP0004043_abnormal_pH_regulation1.32480063
49MP0002066_abnormal_motor_capabilities/c1.31991763
50MP0002751_abnormal_autonomic_nervous1.26995631
51MP0003879_abnormal_hair_cell1.22781183
52MP0002152_abnormal_brain_morphology1.21336966
53MP0004742_abnormal_vestibular_system1.20580388
54MP0001529_abnormal_vocalization1.20390926
55MP0002090_abnormal_vision1.19427340
56MP0003329_amyloid_beta_deposits1.17236235
57MP0006072_abnormal_retinal_apoptosis1.16776981
58MP0002752_abnormal_somatic_nervous1.15653071
59MP0003136_yellow_coat_color1.12646332
60MP0005253_abnormal_eye_physiology1.11484519
61MP0004233_abnormal_muscle_weight1.11378437
62MP0001905_abnormal_dopamine_level1.10681121
63MP0002102_abnormal_ear_morphology1.09140897
64MP0004142_abnormal_muscle_tone1.09013601
65MP0005646_abnormal_pituitary_gland1.08385719
66MP0003633_abnormal_nervous_system1.07572399
67MP0010386_abnormal_urinary_bladder1.06760111
68MP0003283_abnormal_digestive_organ1.05377786
69MP0002229_neurodegeneration1.04827663
70MP0000751_myopathy1.02811357
71MP0005394_taste/olfaction_phenotype1.01166614
72MP0005499_abnormal_olfactory_system1.01166614
73MP0003631_nervous_system_phenotype0.97363674
74MP0000015_abnormal_ear_pigmentation0.96489095
75MP0002938_white_spotting0.96203489
76MP0004145_abnormal_muscle_electrophysio0.95125342
77MP0003137_abnormal_impulse_conducting0.93791669
78MP0000631_abnormal_neuroendocrine_gland0.90013803
79MP0002653_abnormal_ependyma_morphology0.88807307
80MP0000749_muscle_degeneration0.88501525
81MP0003123_paternal_imprinting0.88101051
82MP0001986_abnormal_taste_sensitivity0.87847683
83MP0004085_abnormal_heartbeat0.87235758
84MP0002069_abnormal_eating/drinking_beha0.86636956
85MP0001485_abnormal_pinna_reflex0.86426365
86MP0001963_abnormal_hearing_physiology0.84161249
87MP0003195_calcinosis0.82931914
88MP0003861_abnormal_nervous_system0.82794057
89MP0005195_abnormal_posterior_eye0.81788237
90MP0005171_absent_coat_pigmentation0.81476173
91MP0003634_abnormal_glial_cell0.80594760
92MP0002234_abnormal_pharynx_morphology0.79491257
93MP0001299_abnormal_eye_distance/0.79019577
94MP0005075_abnormal_melanosome_morpholog0.78969950
95MP0005409_darkened_coat_color0.78473486
96MP0004147_increased_porphyrin_level0.77753029
97MP0002876_abnormal_thyroid_physiology0.77735069
98MP0001177_atelectasis0.77045832
99MP0003632_abnormal_nervous_system0.75451428
100MP0003646_muscle_fatigue0.74648130
101MP0004510_myositis0.71608557
102MP0004130_abnormal_muscle_cell0.69276025
103MP0004484_altered_response_of0.68981366
104MP0004215_abnormal_myocardial_fiber0.66926500
105MP0008872_abnormal_physiological_respon0.66770190
106MP0005620_abnormal_muscle_contractility0.66324648
107MP0005623_abnormal_meninges_morphology0.63620133
108MP0002095_abnormal_skin_pigmentation0.63589840
109MP0000534_abnormal_ureter_morphology0.62865759
110MP0006292_abnormal_olfactory_placode0.62783146
111MP0000026_abnormal_inner_ear0.62453583
112MP0002106_abnormal_muscle_physiology0.62108258
113MP0000920_abnormal_myelination0.61915260
114MP0005187_abnormal_penis_morphology0.61515991
115MP0008874_decreased_physiological_sensi0.60596574
116MP0004036_abnormal_muscle_relaxation0.59411222
117MP0001943_abnormal_respiration0.59152028
118MP0010769_abnormal_survival0.57640257
119MP0003121_genomic_imprinting0.57452103
120MP0002837_dystrophic_cardiac_calcinosis0.57352990
121MP0003045_fibrosis0.57089709
122MP0008961_abnormal_basal_metabolism0.56946822
123MP0002082_postnatal_lethality0.56883302
124MP0010770_preweaning_lethality0.56883302

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.96001945
2Myokymia (HP:0002411)5.44947939
3Focal seizures (HP:0007359)4.93924510
4Epileptic encephalopathy (HP:0200134)4.64372126
5Progressive cerebellar ataxia (HP:0002073)4.51495355
6Febrile seizures (HP:0002373)4.27834723
7Visual hallucinations (HP:0002367)4.15833900
8Atonic seizures (HP:0010819)3.90530987
9Action tremor (HP:0002345)3.81252793
10Amblyopia (HP:0000646)3.50916366
11Broad-based gait (HP:0002136)3.49625775
12Absence seizures (HP:0002121)3.49480091
13Congenital stationary night blindness (HP:0007642)3.46018652
14Mutism (HP:0002300)3.42481288
15Dialeptic seizures (HP:0011146)3.31298419
16Hyperventilation (HP:0002883)3.28999715
17Generalized tonic-clonic seizures (HP:0002069)3.14358152
18Central scotoma (HP:0000603)3.07278618
19Supranuclear gaze palsy (HP:0000605)3.06567881
20Truncal ataxia (HP:0002078)3.00696607
21Gaze-evoked nystagmus (HP:0000640)3.00000875
22Excessive salivation (HP:0003781)2.99358267
23Drooling (HP:0002307)2.99358267
24Genetic anticipation (HP:0003743)2.97891537
25Ankle clonus (HP:0011448)2.88877660
26Limb dystonia (HP:0002451)2.86200377
27Poor eye contact (HP:0000817)2.76016812
28Spastic tetraparesis (HP:0001285)2.72276083
29Urinary bladder sphincter dysfunction (HP:0002839)2.69888078
30Absent speech (HP:0001344)2.68942997
31Depression (HP:0000716)2.66986039
32Syncope (HP:0001279)2.66237377
33Pheochromocytoma (HP:0002666)2.64643823
34Cerebral hypomyelination (HP:0006808)2.62158129
35Impaired vibration sensation in the lower limbs (HP:0002166)2.58024516
36Dysdiadochokinesis (HP:0002075)2.57344252
37Impaired social interactions (HP:0000735)2.52770882
38Abnormal social behavior (HP:0012433)2.52770882
39Ulnar claw (HP:0001178)2.48861437
40Abnormality of the corticospinal tract (HP:0002492)2.45206024
41Agitation (HP:0000713)2.45005541
42Termporal pattern (HP:0011008)2.44495711
43Insidious onset (HP:0003587)2.44495711
44Progressive inability to walk (HP:0002505)2.43609727
45Stereotypic behavior (HP:0000733)2.43036117
46Abnormal eating behavior (HP:0100738)2.42046593
47Hemiparesis (HP:0001269)2.41791933
48Exotropia (HP:0000577)2.40300633
49Heterochromia iridis (HP:0001100)2.39897693
50Impaired smooth pursuit (HP:0007772)2.39655844
51Hypoventilation (HP:0002791)2.39181553
52Anxiety (HP:0000739)2.38962543
53Epileptiform EEG discharges (HP:0011182)2.38653811
54Failure to thrive in infancy (HP:0001531)2.38115059
55Dyschromatopsia (HP:0007641)2.38012293
56Abnormality of macular pigmentation (HP:0008002)2.36778494
57Dysmetria (HP:0001310)2.36651373
58Papilledema (HP:0001085)2.34996353
59Urinary urgency (HP:0000012)2.32152330
60EEG with generalized epileptiform discharges (HP:0011198)2.29523283
61Abnormal EKG (HP:0003115)2.28746583
62Polyphagia (HP:0002591)2.27336570
63White forelock (HP:0002211)2.26428055
64Bony spicule pigmentary retinopathy (HP:0007737)2.23044034
65Megalencephaly (HP:0001355)2.22308136
66Abnormality of binocular vision (HP:0011514)2.22182302
67Diplopia (HP:0000651)2.22182302
68Spastic gait (HP:0002064)2.19557415
69Torticollis (HP:0000473)2.19462156
70Status epilepticus (HP:0002133)2.18734617
71Neuroendocrine neoplasm (HP:0100634)2.18513929
72Abnormality of the lower motor neuron (HP:0002366)2.18416336
73Bundle branch block (HP:0011710)2.17833601
74Patchy hypopigmentation of hair (HP:0011365)2.17053490
75Dysmetric saccades (HP:0000641)2.16705201
76Hypsarrhythmia (HP:0002521)2.15477655
77Scanning speech (HP:0002168)2.14643400
78Pancreatic cysts (HP:0001737)2.14020020
79Postural instability (HP:0002172)2.11850464
80Abnormality of ocular smooth pursuit (HP:0000617)2.11828951
81Scotoma (HP:0000575)2.11699663
82Inappropriate behavior (HP:0000719)2.10076357
83Congenital sensorineural hearing impairment (HP:0008527)2.08415010
84Amyotrophic lateral sclerosis (HP:0007354)2.08153955
85Abnormal pancreas size (HP:0012094)2.03370503
86Pointed chin (HP:0000307)2.01341894
87Aqueductal stenosis (HP:0002410)2.00829949
88Fetal akinesia sequence (HP:0001989)1.99412911
89Pancreatic fibrosis (HP:0100732)1.97320704
90Abnormality of salivation (HP:0100755)1.97184088
91Hyperthyroidism (HP:0000836)1.97055554
92Ventricular fibrillation (HP:0001663)1.97019434
93Abolished electroretinogram (ERG) (HP:0000550)1.95505551
94Hemiplegia (HP:0002301)1.95418904
95Blue irides (HP:0000635)1.94870828
96Type II lissencephaly (HP:0007260)1.94667225
97True hermaphroditism (HP:0010459)1.93741231
98Focal dystonia (HP:0004373)1.93571578
99Akinesia (HP:0002304)1.93112926
100Medial flaring of the eyebrow (HP:0010747)1.90930464
101Inability to walk (HP:0002540)1.90775578
102Pachygyria (HP:0001302)1.90661598
103Retinal dysplasia (HP:0007973)1.90153411
104Choroideremia (HP:0001139)1.87521394
105Protruding tongue (HP:0010808)1.87046948
106Severe visual impairment (HP:0001141)1.86573421
107Lower limb muscle weakness (HP:0007340)1.85533963
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84669843
109Hypoplasia of the brainstem (HP:0002365)1.84669843
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83023208
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.83023208
112Genital tract atresia (HP:0001827)1.82343919
113Optic nerve hypoplasia (HP:0000609)1.82191925
114Lissencephaly (HP:0001339)1.82013147
115Progressive macrocephaly (HP:0004481)1.81333088
116Specific learning disability (HP:0001328)1.79730404
117Vaginal atresia (HP:0000148)1.78715891
118Intention tremor (HP:0002080)1.77041147
119Autism (HP:0000717)1.76540618
120Delusions (HP:0000746)1.76032103
121Prolonged QT interval (HP:0001657)1.75575980
122Acute necrotizing encephalopathy (HP:0006965)1.75098456
123Incomplete penetrance (HP:0003829)1.73398234
124Renal hypoplasia (HP:0000089)1.73345278
125Macroorchidism (HP:0000053)1.73238490
126Lower limb amyotrophy (HP:0007210)1.73238225
127Decreased central vision (HP:0007663)1.73090668
128Gait imbalance (HP:0002141)1.72465386
129Obstructive sleep apnea (HP:0002870)1.71917846
130Morphological abnormality of the pyramidal tract (HP:0002062)1.69844880
131Pendular nystagmus (HP:0012043)1.69093166
132Abnormal hair whorl (HP:0010721)1.68526891
133CNS hypomyelination (HP:0003429)1.67404067
134Increased corneal curvature (HP:0100692)1.65950890
135Keratoconus (HP:0000563)1.65950890
136Nephronophthisis (HP:0000090)1.65422374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.96860263
2BMPR1B4.26925331
3NTRK33.60938595
4MAP3K93.25867541
5EPHA43.12549940
6MAP3K43.04965507
7FRK2.97567446
8MINK12.80032172
9CASK2.70486146
10MAP2K72.66209835
11DAPK22.26772301
12NTRK22.24386652
13MAPK132.13475337
14PAK62.06542462
15WNK31.97462670
16PRPF4B1.86587340
17MAP2K41.79527840
18KSR11.77873493
19SIK21.69122176
20CCNB11.64416943
21CAMKK11.62820304
22NTRK11.58911931
23KSR21.54747837
24MAP3K121.52896326
25PLK21.52301052
26CDK51.49598222
27PNCK1.44815091
28PHKG11.37546933
29PHKG21.37546933
30OBSCN1.35147118
31GRK11.34626642
32PRKD31.23426243
33TNIK1.20316999
34CDK191.18210981
35SGK2231.15330059
36SGK4941.15330059
37GRK51.13121580
38STK381.12590162
39TYRO31.11617401
40RET1.11363219
41FES1.11002367
42INSRR1.10374930
43DAPK11.09362079
44PRKCG1.07449325
45CAMKK21.06672310
46LATS21.04575077
47SGK21.04093023
48ADRBK21.02686294
49DYRK1A1.02438755
50UHMK11.02392127
51CSNK1G21.02053539
52AKT30.99732997
53CAMK2A0.99337331
54CAMK10.95763499
55CDK180.90053532
56CDK140.89340462
57SIK30.87509360
58CAMK1G0.86656907
59CDK150.86395556
60DYRK20.83918814
61MARK20.83812225
62STK110.83175225
63CAMK40.82092323
64SGK30.81809013
65MAP4K20.80429326
66ERBB30.80215982
67RIPK40.78909669
68PAK30.78172013
69CAMK2B0.76258075
70NUAK10.74404602
71CDK30.73723823
72CDK11A0.72603571
73PRKCH0.72153661
74TAOK20.71377349
75LIMK10.71371998
76RPS6KA20.67671100
77PRKCZ0.66795222
78SGK10.66588729
79PTK2B0.66363025
80MAP3K20.66089542
81ALK0.65266666
82TNK20.64497876
83MKNK20.63271016
84PINK10.60742520
85CDK80.59355196
86PRKACA0.57656705
87CAMK1D0.54677821
88PRKCE0.53391916
89CSNK1G10.53088182
90ERBB20.52694940
91WNK10.51325080
92FYN0.49961871
93WNK40.49274459
94FGFR20.47937536
95RIPK10.47638022
96RPS6KA30.47237268
97GRK70.46927615
98ARAF0.46678697
99CAMK2D0.46438362
100EIF2AK30.45931396
101PRKG10.45667061
102CDC42BPA0.45504447
103IRAK20.45458014
104ADRBK10.45336101
105MUSK0.45111924
106CAMK2G0.44927365
107PDK10.44915641
108EPHB20.44703835
109PKN10.44453841
110MAPK120.44168105
111CSNK1A10.43879408
112ROCK10.43805107
113STK390.43771364
114OXSR10.43278483
115CSNK1A1L0.43022730
116CSNK1G30.42859962
117FER0.42748679
118MAPK80.41803936
119PASK0.41606484
120MAPK100.41246554
121PRKAA10.40260978
122CSNK1D0.39359548
123DMPK0.39282376
124PDPK10.39183095
125LMTK20.39170704
126MAP2K10.38751362
127FGR0.38684225
128BCR0.36933741
129TIE10.36425154

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55984440
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12910234
3Olfactory transduction_Homo sapiens_hsa047402.65100178
4Circadian entrainment_Homo sapiens_hsa047132.53296144
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51217070
6GABAergic synapse_Homo sapiens_hsa047272.45266610
7Morphine addiction_Homo sapiens_hsa050322.37522155
8Glutamatergic synapse_Homo sapiens_hsa047242.35150334
9Phototransduction_Homo sapiens_hsa047442.34422795
10Long-term potentiation_Homo sapiens_hsa047202.33094571
11Dopaminergic synapse_Homo sapiens_hsa047282.12297526
12Amphetamine addiction_Homo sapiens_hsa050312.11468863
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03813437
14Cholinergic synapse_Homo sapiens_hsa047251.96391815
15Salivary secretion_Homo sapiens_hsa049701.90475685
16Insulin secretion_Homo sapiens_hsa049111.81227232
17Long-term depression_Homo sapiens_hsa047301.75826216
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73042693
19Serotonergic synapse_Homo sapiens_hsa047261.66762704
20Taste transduction_Homo sapiens_hsa047421.66039762
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58358338
22Oxytocin signaling pathway_Homo sapiens_hsa049211.57515390
23Renin secretion_Homo sapiens_hsa049241.56035972
24Gastric acid secretion_Homo sapiens_hsa049711.55868132
25Axon guidance_Homo sapiens_hsa043601.55477221
26Cocaine addiction_Homo sapiens_hsa050301.54456361
27Oxidative phosphorylation_Homo sapiens_hsa001901.48527834
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42949400
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39617579
30Gap junction_Homo sapiens_hsa045401.38944126
31Calcium signaling pathway_Homo sapiens_hsa040201.38890974
32GnRH signaling pathway_Homo sapiens_hsa049121.33587612
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.32788467
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30663588
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29791018
36Type II diabetes mellitus_Homo sapiens_hsa049301.21924148
37cAMP signaling pathway_Homo sapiens_hsa040241.21381289
38Glioma_Homo sapiens_hsa052141.19199456
39Alzheimers disease_Homo sapiens_hsa050101.19197144
40ErbB signaling pathway_Homo sapiens_hsa040121.17350795
41Parkinsons disease_Homo sapiens_hsa050121.16272547
42Collecting duct acid secretion_Homo sapiens_hsa049661.10359087
43Estrogen signaling pathway_Homo sapiens_hsa049151.10258696
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04893907
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02339142
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01729265
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98814357
48Melanogenesis_Homo sapiens_hsa049160.98453570
49Dilated cardiomyopathy_Homo sapiens_hsa054140.93738666
50Cardiac muscle contraction_Homo sapiens_hsa042600.90619122
51Nitrogen metabolism_Homo sapiens_hsa009100.89799143
52Vibrio cholerae infection_Homo sapiens_hsa051100.87066039
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.83443429
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.82700663
55Butanoate metabolism_Homo sapiens_hsa006500.82229812
56Dorso-ventral axis formation_Homo sapiens_hsa043200.82144104
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.81831388
58Endometrial cancer_Homo sapiens_hsa052130.80511675
59MAPK signaling pathway_Homo sapiens_hsa040100.80234565
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79858837
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.79611469
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76559807
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76376581
64Ether lipid metabolism_Homo sapiens_hsa005650.76203369
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75201457
66Circadian rhythm_Homo sapiens_hsa047100.73799337
67Oocyte meiosis_Homo sapiens_hsa041140.72107599
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71728832
69Choline metabolism in cancer_Homo sapiens_hsa052310.70923019
70Rap1 signaling pathway_Homo sapiens_hsa040150.70846950
71VEGF signaling pathway_Homo sapiens_hsa043700.70144160
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68650213
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68610891
74Ras signaling pathway_Homo sapiens_hsa040140.68499186
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68246671
76Regulation of autophagy_Homo sapiens_hsa041400.67111653
77Renal cell carcinoma_Homo sapiens_hsa052110.67022827
78Pancreatic secretion_Homo sapiens_hsa049720.66890214
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66116550
80Huntingtons disease_Homo sapiens_hsa050160.65714143
81Vitamin B6 metabolism_Homo sapiens_hsa007500.64855378
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61757875
83Colorectal cancer_Homo sapiens_hsa052100.61424761
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61271074
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61126445
86Thyroid hormone synthesis_Homo sapiens_hsa049180.61090559
87Wnt signaling pathway_Homo sapiens_hsa043100.59718023
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58896383
89mTOR signaling pathway_Homo sapiens_hsa041500.58855895
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58835634
91Non-small cell lung cancer_Homo sapiens_hsa052230.57548661
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.57021666
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56780739
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55018280
95Fatty acid elongation_Homo sapiens_hsa000620.54217787
96Glucagon signaling pathway_Homo sapiens_hsa049220.51958258
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51687511
98Linoleic acid metabolism_Homo sapiens_hsa005910.51453677
99Endocytosis_Homo sapiens_hsa041440.50251076
100Insulin signaling pathway_Homo sapiens_hsa049100.50120706
101ABC transporters_Homo sapiens_hsa020100.49418849
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49356597
103Bile secretion_Homo sapiens_hsa049760.48953285
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48691658
105Glycerolipid metabolism_Homo sapiens_hsa005610.48413831
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47406297
107Alcoholism_Homo sapiens_hsa050340.46866938
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46756459
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45488759
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44916536
111Protein export_Homo sapiens_hsa030600.43130110
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41887731
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.41506649
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.41251885
115beta-Alanine metabolism_Homo sapiens_hsa004100.40615771
116Inositol phosphate metabolism_Homo sapiens_hsa005620.40474286
117Hedgehog signaling pathway_Homo sapiens_hsa043400.38426376
118Chemokine signaling pathway_Homo sapiens_hsa040620.38270434
119Ovarian steroidogenesis_Homo sapiens_hsa049130.37187964
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36731933
121Prion diseases_Homo sapiens_hsa050200.36520808
122Melanoma_Homo sapiens_hsa052180.36251226
123Hippo signaling pathway_Homo sapiens_hsa043900.36219382
124Tryptophan metabolism_Homo sapiens_hsa003800.35902136
125Prolactin signaling pathway_Homo sapiens_hsa049170.35740863
126Basal transcription factors_Homo sapiens_hsa030220.34692667
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34093748
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33989644
129Phagosome_Homo sapiens_hsa041450.33645003
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32961532
131Peroxisome_Homo sapiens_hsa041460.32754072
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32696897
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32015857
134Platelet activation_Homo sapiens_hsa046110.31427705
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29618636

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »