

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 7.37438079 |
| 2 | cellular potassium ion homeostasis (GO:0030007) | 6.10374628 |
| 3 | glutamate secretion (GO:0014047) | 6.08847436 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 6.01649336 |
| 5 | vocalization behavior (GO:0071625) | 5.99675710 |
| 6 | sodium ion export (GO:0071436) | 5.89835919 |
| 7 | neurotransmitter-gated ion channel clustering (GO:0072578) | 5.82396074 |
| 8 | presynaptic membrane assembly (GO:0097105) | 5.79944330 |
| 9 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 5.68962328 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 5.68280529 |
| 11 | L-amino acid import (GO:0043092) | 5.49498447 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.48978241 |
| 13 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.48724238 |
| 14 | amino acid import (GO:0043090) | 5.38585009 |
| 15 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.37844723 |
| 16 | presynaptic membrane organization (GO:0097090) | 5.25978694 |
| 17 | protein localization to synapse (GO:0035418) | 5.23815849 |
| 18 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.22340132 |
| 19 | neuron cell-cell adhesion (GO:0007158) | 5.19156166 |
| 20 | postsynaptic membrane organization (GO:0001941) | 5.11786350 |
| 21 | synaptic vesicle maturation (GO:0016188) | 4.98013028 |
| 22 | regulation of synaptic vesicle transport (GO:1902803) | 4.76508144 |
| 23 | neuronal action potential propagation (GO:0019227) | 4.72268928 |
| 24 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.45934106 |
| 25 | synaptic transmission, glutamatergic (GO:0035249) | 4.44838558 |
| 26 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.43068433 |
| 27 | neuron-neuron synaptic transmission (GO:0007270) | 4.34961749 |
| 28 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.26317563 |
| 29 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.23212199 |
| 30 | locomotory exploration behavior (GO:0035641) | 4.22885939 |
| 31 | long-term synaptic potentiation (GO:0060291) | 4.22654435 |
| 32 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.17976000 |
| 33 | neurotransmitter secretion (GO:0007269) | 4.15637780 |
| 34 | mechanosensory behavior (GO:0007638) | 4.14428366 |
| 35 | potassium ion homeostasis (GO:0055075) | 4.05752217 |
| 36 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.04192540 |
| 37 | glutamate receptor signaling pathway (GO:0007215) | 4.02088249 |
| 38 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.99967870 |
| 39 | positive regulation of synapse maturation (GO:0090129) | 3.98872351 |
| 40 | neuronal ion channel clustering (GO:0045161) | 3.97822877 |
| 41 | layer formation in cerebral cortex (GO:0021819) | 3.97745475 |
| 42 | cerebellar granule cell differentiation (GO:0021707) | 3.92918331 |
| 43 | potassium ion import (GO:0010107) | 3.87160033 |
| 44 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.86634900 |
| 45 | regulation of postsynaptic membrane potential (GO:0060078) | 3.82819713 |
| 46 | positive regulation of neurotransmitter transport (GO:0051590) | 3.80712917 |
| 47 | regulation of neurotransmitter secretion (GO:0046928) | 3.80291754 |
| 48 | response to histamine (GO:0034776) | 3.78993902 |
| 49 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.78237970 |
| 50 | cellular sodium ion homeostasis (GO:0006883) | 3.74678518 |
| 51 | transferrin transport (GO:0033572) | 3.72117348 |
| 52 | positive regulation of membrane potential (GO:0045838) | 3.71963903 |
| 53 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.65961462 |
| 54 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.64828942 |
| 55 | regulation of synaptic plasticity (GO:0048167) | 3.64423182 |
| 56 | startle response (GO:0001964) | 3.62225756 |
| 57 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.62190954 |
| 58 | acidic amino acid transport (GO:0015800) | 3.57845253 |
| 59 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.57729272 |
| 60 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.56130256 |
| 61 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.56130256 |
| 62 | cell communication by electrical coupling (GO:0010644) | 3.54960996 |
| 63 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.54908336 |
| 64 | positive regulation of dendritic spine development (GO:0060999) | 3.51221803 |
| 65 | auditory behavior (GO:0031223) | 3.47025129 |
| 66 | neurotransmitter uptake (GO:0001504) | 3.46227383 |
| 67 | ferric iron transport (GO:0015682) | 3.45423870 |
| 68 | trivalent inorganic cation transport (GO:0072512) | 3.45423870 |
| 69 | neuromuscular process controlling balance (GO:0050885) | 3.44048304 |
| 70 | regulation of synapse maturation (GO:0090128) | 3.43088250 |
| 71 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.42235251 |
| 72 | central nervous system myelination (GO:0022010) | 3.38965309 |
| 73 | axon ensheathment in central nervous system (GO:0032291) | 3.38965309 |
| 74 | proline transport (GO:0015824) | 3.37644952 |
| 75 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.37328382 |
| 76 | exploration behavior (GO:0035640) | 3.36924839 |
| 77 | regulation of neurotransmitter transport (GO:0051588) | 3.33662695 |
| 78 | regulation of ARF protein signal transduction (GO:0032012) | 3.31492376 |
| 79 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.30474557 |
| 80 | neurotransmitter transport (GO:0006836) | 3.29421881 |
| 81 | positive regulation of synapse assembly (GO:0051965) | 3.29167793 |
| 82 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.28981503 |
| 83 | synaptic vesicle endocytosis (GO:0048488) | 3.28931736 |
| 84 | positive regulation of synaptic transmission (GO:0050806) | 3.24292991 |
| 85 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.20464665 |
| 86 | neuron recognition (GO:0008038) | 3.18849789 |
| 87 | phosphorelay signal transduction system (GO:0000160) | 3.18123720 |
| 88 | behavioral response to cocaine (GO:0048148) | 3.16663471 |
| 89 | negative regulation of dendrite development (GO:2000171) | 3.15846691 |
| 90 | long-term memory (GO:0007616) | 3.12355402 |
| 91 | membrane depolarization (GO:0051899) | 3.11686984 |
| 92 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.11546661 |
| 93 | synaptic vesicle transport (GO:0048489) | 3.10527814 |
| 94 | establishment of synaptic vesicle localization (GO:0097480) | 3.10527814 |
| 95 | long term synaptic depression (GO:0060292) | 3.09503657 |
| 96 | regulation of cell communication by electrical coupling (GO:0010649) | 3.08242830 |
| 97 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.08151889 |
| 98 | female mating behavior (GO:0060180) | 3.08030031 |
| 99 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.07567669 |
| 100 | behavioral fear response (GO:0001662) | 3.07545301 |
| 101 | behavioral defense response (GO:0002209) | 3.07545301 |
| 102 | transmission of nerve impulse (GO:0019226) | 3.06836530 |
| 103 | gamma-aminobutyric acid transport (GO:0015812) | 3.06199133 |
| 104 | serotonin metabolic process (GO:0042428) | 3.04937739 |
| 105 | dicarboxylic acid transport (GO:0006835) | 3.03995993 |
| 106 | response to auditory stimulus (GO:0010996) | 3.01346288 |
| 107 | regulation of synaptic transmission (GO:0050804) | 2.99789238 |
| 108 | response to gravity (GO:0009629) | 2.99720195 |
| 109 | L-glutamate transport (GO:0015813) | 2.99627575 |
| 110 | mitochondrion distribution (GO:0048311) | 2.99356640 |
| 111 | regulation of synapse structural plasticity (GO:0051823) | 2.99050442 |
| 112 | synaptic transmission (GO:0007268) | 2.98980001 |
| 113 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.98099535 |
| 114 | vesicle docking involved in exocytosis (GO:0006904) | 2.96813143 |
| 115 | regulation of vesicle fusion (GO:0031338) | 2.95913467 |
| 116 | regulation of female receptivity (GO:0045924) | 2.94293084 |
| 117 | regulation of neurotransmitter levels (GO:0001505) | 2.94223048 |
| 118 | regulation of synapse assembly (GO:0051963) | 2.94080421 |
| 119 | regulation of glutamate secretion (GO:0014048) | 2.93830730 |
| 120 | regulation of dendritic spine development (GO:0060998) | 2.90856743 |
| 121 | learning (GO:0007612) | 2.88731630 |
| 122 | cochlea development (GO:0090102) | 2.88231370 |
| 123 | axonal fasciculation (GO:0007413) | 2.87619619 |
| 124 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.86944590 |
| 125 | calcium ion-dependent exocytosis (GO:0017156) | 2.86902226 |
| 126 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.84802227 |
| 127 | activation of protein kinase A activity (GO:0034199) | 2.82942705 |
| 128 | detection of calcium ion (GO:0005513) | 2.82338051 |
| 129 | membrane depolarization during action potential (GO:0086010) | 2.82082374 |
| 130 | vesicle docking (GO:0048278) | 2.81618596 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.94158024 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.86264315 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.04098767 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.87962831 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.82443159 |
| 6 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.70872243 |
| 7 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.69017105 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.55134102 |
| 9 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.50151539 |
| 10 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.41512761 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.40289991 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.38376664 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.38376664 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.35597852 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.33701216 |
| 16 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.33455894 |
| 17 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.33220216 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.27912789 |
| 19 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.26765527 |
| 20 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.18785164 |
| 21 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.16787100 |
| 22 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.12593448 |
| 23 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.12108051 |
| 24 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.09585262 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.07784562 |
| 26 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.07117025 |
| 27 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.02311044 |
| 28 | SMAD4_21799915_ChIP-Seq_A2780_Human | 2.00314800 |
| 29 | P300_19829295_ChIP-Seq_ESCs_Human | 1.98228195 |
| 30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.92679975 |
| 31 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.92465201 |
| 32 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.89457861 |
| 33 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.88548678 |
| 34 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.86566444 |
| 35 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.85390613 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.83701503 |
| 37 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.81916271 |
| 38 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.80786883 |
| 39 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.79040862 |
| 40 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.71106247 |
| 41 | FUS_26573619_Chip-Seq_HEK293_Human | 1.69348215 |
| 42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.67893956 |
| 43 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.64872357 |
| 44 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.63556539 |
| 45 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.61452486 |
| 46 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.57334773 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.57053761 |
| 48 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.55341707 |
| 49 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.54046976 |
| 50 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.54013446 |
| 51 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.52124914 |
| 52 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.50576357 |
| 53 | AR_25329375_ChIP-Seq_VCAP_Human | 1.49620727 |
| 54 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.48728817 |
| 55 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.46030475 |
| 56 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.45694929 |
| 57 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.45546630 |
| 58 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.44141190 |
| 59 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.44085141 |
| 60 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.43105620 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.39225086 |
| 62 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.38599648 |
| 63 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.38032841 |
| 64 | STAT3_23295773_ChIP-Seq_U87_Human | 1.38008566 |
| 65 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.35920503 |
| 66 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.32331618 |
| 67 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.32312439 |
| 68 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.32130518 |
| 69 | TCF4_23295773_ChIP-Seq_U87_Human | 1.31764180 |
| 70 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.30352059 |
| 71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.29187494 |
| 72 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.28263224 |
| 73 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.28196067 |
| 74 | KDM2B_26808549_Chip-Seq_K562_Human | 1.27503044 |
| 75 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.26055376 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.25770706 |
| 77 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.25039497 |
| 78 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.24447548 |
| 79 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.24217133 |
| 80 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.23663354 |
| 81 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.21358930 |
| 82 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.20697343 |
| 83 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.20201136 |
| 84 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.19109942 |
| 85 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.17428363 |
| 86 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.17295318 |
| 87 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.15751209 |
| 88 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.15027417 |
| 89 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.14534504 |
| 90 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.14307595 |
| 91 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13364999 |
| 92 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.13347693 |
| 93 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.12875163 |
| 94 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.12663907 |
| 95 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.10599167 |
| 96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.10169285 |
| 97 | JUN_21703547_ChIP-Seq_K562_Human | 1.09518320 |
| 98 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.09352657 |
| 99 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.09237109 |
| 100 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.09151907 |
| 101 | AR_19668381_ChIP-Seq_PC3_Human | 1.08821293 |
| 102 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.08057038 |
| 103 | * RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.05900419 |
| 104 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.05727029 |
| 105 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.04929869 |
| 106 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.04719762 |
| 107 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.03692987 |
| 108 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02594747 |
| 109 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.02496088 |
| 110 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01703384 |
| 111 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.01518762 |
| 112 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.01304535 |
| 113 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.00666856 |
| 114 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.00430704 |
| 115 | KDM2B_26808549_Chip-Seq_REH_Human | 1.00333387 |
| 116 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.99907241 |
| 117 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.99848306 |
| 118 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99824381 |
| 119 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.99824381 |
| 120 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.99811625 |
| 121 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.99655099 |
| 122 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.99306705 |
| 123 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.99079606 |
| 124 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.98241600 |
| 125 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.95013203 |
| 126 | * LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.89111236 |
| 127 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.88550452 |
| 128 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.88295361 |
| 129 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.87088503 |
| 130 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.86052277 |
| 131 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.86024368 |
| 132 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.85655635 |
| 133 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.84957218 |
| 134 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.84676014 |
| 135 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.84367980 |
| 136 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.82012371 |
| 137 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80352010 |
| 138 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.80302632 |
| 139 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.80238941 |
| 140 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.78185252 |
| 141 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 0.76890922 |
| 142 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.76736624 |
| 143 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.76392629 |
| 144 | POU3F1_26484290_ChIP-Seq_ESCss_Mouse | 0.76388064 |
| 145 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.75607668 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.94369636 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 5.66858023 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.90645595 |
| 4 | MP0009745_abnormal_behavioral_response | 3.51358197 |
| 5 | MP0001968_abnormal_touch/_nociception | 3.51080055 |
| 6 | MP0004270_analgesia | 3.46111843 |
| 7 | MP0009046_muscle_twitch | 3.33336391 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.31367493 |
| 9 | MP0002064_seizures | 3.24778046 |
| 10 | MP0002736_abnormal_nociception_after | 3.22185869 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.93649583 |
| 12 | MP0002735_abnormal_chemical_nociception | 2.68753892 |
| 13 | MP0002734_abnormal_mechanical_nocicepti | 2.64488731 |
| 14 | MP0002272_abnormal_nervous_system | 2.56646081 |
| 15 | MP0005646_abnormal_pituitary_gland | 2.44931321 |
| 16 | MP0009780_abnormal_chondrocyte_physiolo | 2.43373535 |
| 17 | MP0001486_abnormal_startle_reflex | 2.39595227 |
| 18 | MP0003787_abnormal_imprinting | 2.39422570 |
| 19 | MP0003879_abnormal_hair_cell | 2.39247869 |
| 20 | MP0001501_abnormal_sleep_pattern | 2.22366496 |
| 21 | MP0002067_abnormal_sensory_capabilities | 2.15052788 |
| 22 | MP0001440_abnormal_grooming_behavior | 2.09227193 |
| 23 | MP0002876_abnormal_thyroid_physiology | 2.06800097 |
| 24 | MP0001984_abnormal_olfaction | 1.84335835 |
| 25 | MP0001970_abnormal_pain_threshold | 1.77637311 |
| 26 | MP0008004_abnormal_stomach_pH | 1.76666908 |
| 27 | MP0001188_hyperpigmentation | 1.74127003 |
| 28 | MP0002557_abnormal_social/conspecific_i | 1.73944475 |
| 29 | MP0002733_abnormal_thermal_nociception | 1.71122334 |
| 30 | MP0003122_maternal_imprinting | 1.65647600 |
| 31 | MP0000778_abnormal_nervous_system | 1.57170386 |
| 32 | MP0008569_lethality_at_weaning | 1.57167471 |
| 33 | MP0002184_abnormal_innervation | 1.53535437 |
| 34 | MP0005386_behavior/neurological_phenoty | 1.52525272 |
| 35 | MP0004924_abnormal_behavior | 1.52525272 |
| 36 | MP0006276_abnormal_autonomic_nervous | 1.51016517 |
| 37 | MP0005645_abnormal_hypothalamus_physiol | 1.46029918 |
| 38 | MP0005423_abnormal_somatic_nervous | 1.45608121 |
| 39 | MP0002822_catalepsy | 1.42054864 |
| 40 | MP0004811_abnormal_neuron_physiology | 1.41192144 |
| 41 | MP0001502_abnormal_circadian_rhythm | 1.37641773 |
| 42 | MP0002837_dystrophic_cardiac_calcinosis | 1.36718432 |
| 43 | MP0000920_abnormal_myelination | 1.36172084 |
| 44 | MP0001346_abnormal_lacrimal_gland | 1.33743150 |
| 45 | MP0010234_abnormal_vibrissa_follicle | 1.29596173 |
| 46 | MP0003633_abnormal_nervous_system | 1.27287353 |
| 47 | MP0002066_abnormal_motor_capabilities/c | 1.26646632 |
| 48 | MP0003690_abnormal_glial_cell | 1.25574945 |
| 49 | MP0004142_abnormal_muscle_tone | 1.24275187 |
| 50 | MP0005171_absent_coat_pigmentation | 1.21542319 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.17145282 |
| 52 | MP0001986_abnormal_taste_sensitivity | 1.16204171 |
| 53 | MP0001905_abnormal_dopamine_level | 1.15219430 |
| 54 | MP0004858_abnormal_nervous_system | 1.14417893 |
| 55 | MP0010386_abnormal_urinary_bladder | 1.13778650 |
| 56 | MP0002909_abnormal_adrenal_gland | 1.13591725 |
| 57 | MP0003634_abnormal_glial_cell | 1.12185630 |
| 58 | MP0003183_abnormal_peptide_metabolism | 1.12179145 |
| 59 | MP0001963_abnormal_hearing_physiology | 1.10836573 |
| 60 | MP0001348_abnormal_lacrimal_gland | 1.10826176 |
| 61 | MP0000751_myopathy | 1.09864425 |
| 62 | MP0000955_abnormal_spinal_cord | 1.09790641 |
| 63 | MP0000013_abnormal_adipose_tissue | 1.02837996 |
| 64 | MP0004484_altered_response_of | 1.02327946 |
| 65 | MP0004147_increased_porphyrin_level | 1.01994992 |
| 66 | MP0003631_nervous_system_phenotype | 1.00791060 |
| 67 | MP0004215_abnormal_myocardial_fiber | 0.98897532 |
| 68 | MP0001529_abnormal_vocalization | 0.98814180 |
| 69 | MP0008877_abnormal_DNA_methylation | 0.98298614 |
| 70 | MP0004085_abnormal_heartbeat | 0.96212738 |
| 71 | MP0008872_abnormal_physiological_respon | 0.90984403 |
| 72 | MP0003329_amyloid_beta_deposits | 0.90225657 |
| 73 | MP0001485_abnormal_pinna_reflex | 0.89830579 |
| 74 | MP0003632_abnormal_nervous_system | 0.88303952 |
| 75 | MP0001664_abnormal_digestion | 0.87702969 |
| 76 | MP0002152_abnormal_brain_morphology | 0.87167079 |
| 77 | MP0004742_abnormal_vestibular_system | 0.86432943 |
| 78 | MP0002653_abnormal_ependyma_morphology | 0.86156480 |
| 79 | MP0002069_abnormal_eating/drinking_beha | 0.85293820 |
| 80 | MP0008874_decreased_physiological_sensi | 0.82108243 |
| 81 | MP0004145_abnormal_muscle_electrophysio | 0.81611365 |
| 82 | MP0000631_abnormal_neuroendocrine_gland | 0.81164364 |
| 83 | MP0005551_abnormal_eye_electrophysiolog | 0.78827554 |
| 84 | MP0002229_neurodegeneration | 0.75399519 |
| 85 | MP0000604_amyloidosis | 0.74449118 |
| 86 | MP0003646_muscle_fatigue | 0.73369251 |
| 87 | MP0000026_abnormal_inner_ear | 0.73197995 |
| 88 | MP0005535_abnormal_body_temperature | 0.71605423 |
| 89 | MP0003075_altered_response_to | 0.70231098 |
| 90 | MP0004043_abnormal_pH_regulation | 0.69645561 |
| 91 | MP0004885_abnormal_endolymph | 0.69043006 |
| 92 | MP0001177_atelectasis | 0.67770137 |
| 93 | MP0002160_abnormal_reproductive_system | 0.66827731 |
| 94 | MP0003136_yellow_coat_color | 0.66262669 |
| 95 | MP0005394_taste/olfaction_phenotype | 0.64907833 |
| 96 | MP0005499_abnormal_olfactory_system | 0.64907833 |
| 97 | MP0003121_genomic_imprinting | 0.64795074 |
| 98 | MP0002090_abnormal_vision | 0.62996387 |
| 99 | MP0003956_abnormal_body_size | 0.62688691 |
| 100 | MP0003861_abnormal_nervous_system | 0.62552467 |
| 101 | MP0000579_abnormal_nail_morphology | 0.61850486 |
| 102 | MP0002752_abnormal_somatic_nervous | 0.61593953 |
| 103 | MP0010768_mortality/aging | 0.60140800 |
| 104 | MP0002638_abnormal_pupillary_reflex | 0.58147629 |
| 105 | MP0004036_abnormal_muscle_relaxation | 0.58120831 |
| 106 | MP0005084_abnormal_gallbladder_morpholo | 0.56909077 |
| 107 | MP0001943_abnormal_respiration | 0.55289264 |
| 108 | MP0010094_abnormal_chromosome_stability | 0.55277874 |
| 109 | MP0002873_normal_phenotype | 0.55099017 |
| 110 | MP0002169_no_abnormal_phenotype | 0.53347064 |
| 111 | MP0002972_abnormal_cardiac_muscle | 0.53308555 |
| 112 | MP0005620_abnormal_muscle_contractility | 0.53135091 |
| 113 | MP0003137_abnormal_impulse_conducting | 0.52919417 |
| 114 | MP0006292_abnormal_olfactory_placode | 0.51500725 |
| 115 | MP0000749_muscle_degeneration | 0.51489154 |
| 116 | MP0005623_abnormal_meninges_morphology | 0.51442152 |
| 117 | MP0003123_paternal_imprinting | 0.51029986 |
| 118 | MP0002083_premature_death | 0.48851020 |
| 119 | MP0002082_postnatal_lethality | 0.48573387 |
| 120 | MP0010770_preweaning_lethality | 0.48573387 |
| 121 | MP0002877_abnormal_melanocyte_morpholog | 0.48288022 |
| 122 | MP0003698_abnormal_male_reproductive | 0.47493714 |
| 123 | MP0010769_abnormal_survival | 0.46257891 |
| 124 | MP0001731_abnormal_postnatal_growth | 0.46177623 |
| 125 | MP0005310_abnormal_salivary_gland | 0.42122059 |
| 126 | MP0002161_abnormal_fertility/fecundity | 0.41151023 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 9.12999394 |
| 2 | Epileptic encephalopathy (HP:0200134) | 7.02459432 |
| 3 | Atonic seizures (HP:0010819) | 6.50329853 |
| 4 | Hyperventilation (HP:0002883) | 6.03451412 |
| 5 | Febrile seizures (HP:0002373) | 5.98002917 |
| 6 | Focal seizures (HP:0007359) | 5.54911207 |
| 7 | Myokymia (HP:0002411) | 4.83398517 |
| 8 | Absence seizures (HP:0002121) | 4.61432970 |
| 9 | Dialeptic seizures (HP:0011146) | 4.36053714 |
| 10 | Supranuclear gaze palsy (HP:0000605) | 4.28871325 |
| 11 | Broad-based gait (HP:0002136) | 4.12284745 |
| 12 | Spastic gait (HP:0002064) | 4.01312365 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.82918191 |
| 14 | Visual hallucinations (HP:0002367) | 3.82317898 |
| 15 | Gaze-evoked nystagmus (HP:0000640) | 3.54156592 |
| 16 | Progressive cerebellar ataxia (HP:0002073) | 3.52532414 |
| 17 | Amblyopia (HP:0000646) | 3.17569752 |
| 18 | Poor eye contact (HP:0000817) | 3.14447815 |
| 19 | Abnormal hair whorl (HP:0010721) | 3.12705915 |
| 20 | Papilledema (HP:0001085) | 3.07723402 |
| 21 | Pheochromocytoma (HP:0002666) | 3.05780232 |
| 22 | Gait imbalance (HP:0002141) | 3.04524396 |
| 23 | Tetraplegia (HP:0002445) | 3.02297826 |
| 24 | Neurofibrillary tangles (HP:0002185) | 2.98661212 |
| 25 | Protruding tongue (HP:0010808) | 2.97069462 |
| 26 | Epileptiform EEG discharges (HP:0011182) | 2.95614016 |
| 27 | Neuronal loss in central nervous system (HP:0002529) | 2.95481585 |
| 28 | Abnormality of the corticospinal tract (HP:0002492) | 2.92536937 |
| 29 | Cerebral hypomyelination (HP:0006808) | 2.90347944 |
| 30 | Medial flaring of the eyebrow (HP:0010747) | 2.87383066 |
| 31 | Congenital primary aphakia (HP:0007707) | 2.85744383 |
| 32 | Inability to walk (HP:0002540) | 2.80587472 |
| 33 | Abnormal eating behavior (HP:0100738) | 2.79951720 |
| 34 | Nephrogenic diabetes insipidus (HP:0009806) | 2.79183877 |
| 35 | Cerebral inclusion bodies (HP:0100314) | 2.78018213 |
| 36 | Mutism (HP:0002300) | 2.77841524 |
| 37 | Neuroendocrine neoplasm (HP:0100634) | 2.77364348 |
| 38 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.75551167 |
| 39 | Clonus (HP:0002169) | 2.68722514 |
| 40 | Drooling (HP:0002307) | 2.68564709 |
| 41 | Excessive salivation (HP:0003781) | 2.68564709 |
| 42 | Lower limb muscle weakness (HP:0007340) | 2.67925828 |
| 43 | Dysdiadochokinesis (HP:0002075) | 2.67609241 |
| 44 | Dysmetric saccades (HP:0000641) | 2.67101716 |
| 45 | Insomnia (HP:0100785) | 2.65994454 |
| 46 | Intention tremor (HP:0002080) | 2.65287732 |
| 47 | Absent speech (HP:0001344) | 2.65228492 |
| 48 | Blue irides (HP:0000635) | 2.63827019 |
| 49 | Impaired social interactions (HP:0000735) | 2.63752093 |
| 50 | Abnormal social behavior (HP:0012433) | 2.63752093 |
| 51 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.63176959 |
| 52 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.63176959 |
| 53 | Absent/shortened dynein arms (HP:0200106) | 2.62789418 |
| 54 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.62789418 |
| 55 | Akinesia (HP:0002304) | 2.59539992 |
| 56 | Apathy (HP:0000741) | 2.52682980 |
| 57 | Fetal akinesia sequence (HP:0001989) | 2.52076303 |
| 58 | Torticollis (HP:0000473) | 2.47826525 |
| 59 | EEG with generalized epileptiform discharges (HP:0011198) | 2.46039166 |
| 60 | Truncal ataxia (HP:0002078) | 2.41691991 |
| 61 | Annular pancreas (HP:0001734) | 2.39858950 |
| 62 | Hemiplegia (HP:0002301) | 2.36315386 |
| 63 | Polyphagia (HP:0002591) | 2.32607764 |
| 64 | Diminished motivation (HP:0000745) | 2.32374725 |
| 65 | Depression (HP:0000716) | 2.30033672 |
| 66 | Abnormal ciliary motility (HP:0012262) | 2.29526762 |
| 67 | Obstructive sleep apnea (HP:0002870) | 2.29411319 |
| 68 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.29223582 |
| 69 | Anxiety (HP:0000739) | 2.27729236 |
| 70 | Limb dystonia (HP:0002451) | 2.26687186 |
| 71 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.26448181 |
| 72 | Acute necrotizing encephalopathy (HP:0006965) | 2.24144807 |
| 73 | Hypsarrhythmia (HP:0002521) | 2.23255991 |
| 74 | Poor coordination (HP:0002370) | 2.22952748 |
| 75 | Impaired smooth pursuit (HP:0007772) | 2.22377284 |
| 76 | Failure to thrive in infancy (HP:0001531) | 2.21712558 |
| 77 | Status epilepticus (HP:0002133) | 2.21530288 |
| 78 | Impaired vibratory sensation (HP:0002495) | 2.20791419 |
| 79 | Peripheral hypomyelination (HP:0007182) | 2.20437832 |
| 80 | Spastic tetraparesis (HP:0001285) | 2.17487064 |
| 81 | Scanning speech (HP:0002168) | 2.15888079 |
| 82 | Choreoathetosis (HP:0001266) | 2.13440242 |
| 83 | Specific learning disability (HP:0001328) | 2.13024128 |
| 84 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.11424321 |
| 85 | Stereotypic behavior (HP:0000733) | 2.08664762 |
| 86 | Dysmetria (HP:0001310) | 2.08272048 |
| 87 | Abnormality of binocular vision (HP:0011514) | 2.06739664 |
| 88 | Diplopia (HP:0000651) | 2.06739664 |
| 89 | Split foot (HP:0001839) | 2.06611000 |
| 90 | Oligomenorrhea (HP:0000876) | 2.06229578 |
| 91 | Abnormality of the lower motor neuron (HP:0002366) | 2.05797396 |
| 92 | Abnormality of saccadic eye movements (HP:0000570) | 2.05017376 |
| 93 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.03452549 |
| 94 | Progressive macrocephaly (HP:0004481) | 2.02673398 |
| 95 | Abnormality of the labia minora (HP:0012880) | 2.02474519 |
| 96 | Genital tract atresia (HP:0001827) | 2.02255424 |
| 97 | Action tremor (HP:0002345) | 2.01505808 |
| 98 | Vaginal atresia (HP:0000148) | 2.01145880 |
| 99 | Progressive inability to walk (HP:0002505) | 2.01142489 |
| 100 | Hyperthyroidism (HP:0000836) | 2.00659432 |
| 101 | Hemiparesis (HP:0001269) | 1.99622020 |
| 102 | Craniofacial dystonia (HP:0012179) | 1.97471580 |
| 103 | Sensory axonal neuropathy (HP:0003390) | 1.93205903 |
| 104 | Spastic paraplegia (HP:0001258) | 1.92735143 |
| 105 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.92446669 |
| 106 | Rigidity (HP:0002063) | 1.90967158 |
| 107 | Generalized myoclonic seizures (HP:0002123) | 1.90575567 |
| 108 | Bundle branch block (HP:0011710) | 1.90347897 |
| 109 | Ankle clonus (HP:0011448) | 1.90257692 |
| 110 | Genetic anticipation (HP:0003743) | 1.89501614 |
| 111 | Distal sensory impairment (HP:0002936) | 1.89216299 |
| 112 | Abnormality of salivation (HP:0100755) | 1.87540395 |
| 113 | CNS hypomyelination (HP:0003429) | 1.87336431 |
| 114 | Incomplete penetrance (HP:0003829) | 1.86879320 |
| 115 | Poor suck (HP:0002033) | 1.86360184 |
| 116 | Narrow nasal bridge (HP:0000446) | 1.86356735 |
| 117 | Paraplegia (HP:0010550) | 1.85933462 |
| 118 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.84308546 |
| 119 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.84308546 |
| 120 | Sleep apnea (HP:0010535) | 1.83721217 |
| 121 | Slow saccadic eye movements (HP:0000514) | 1.83056404 |
| 122 | Generalized hypopigmentation of hair (HP:0011358) | 1.82270517 |
| 123 | Bradykinesia (HP:0002067) | 1.81597396 |
| 124 | Fair hair (HP:0002286) | 1.78610271 |
| 125 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.78251677 |
| 126 | Resting tremor (HP:0002322) | 1.76509320 |
| 127 | Gait ataxia (HP:0002066) | 1.72227606 |
| 128 | Esotropia (HP:0000565) | 1.69363307 |
| 129 | Delusions (HP:0000746) | 1.68787888 |
| 130 | Postural instability (HP:0002172) | 1.68214320 |
| 131 | Termporal pattern (HP:0011008) | 1.67662430 |
| 132 | Insidious onset (HP:0003587) | 1.67662430 |
| 133 | Mitochondrial inheritance (HP:0001427) | 1.65659945 |
| 134 | Urinary urgency (HP:0000012) | 1.65536416 |
| 135 | Focal dystonia (HP:0004373) | 1.65028547 |
| 136 | Rhinitis (HP:0012384) | 1.64187794 |
| 137 | Thickened helices (HP:0000391) | 1.63067030 |
| 138 | Hypoventilation (HP:0002791) | 1.62136581 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 6.87682409 |
| 2 | EPHA4 | 3.97442160 |
| 3 | NTRK3 | 3.50019778 |
| 4 | DAPK2 | 3.49494240 |
| 5 | CDK19 | 3.21800084 |
| 6 | MAP3K12 | 2.99755231 |
| 7 | MAP2K7 | 2.96418922 |
| 8 | CCNB1 | 2.90982637 |
| 9 | MAP3K4 | 2.64975107 |
| 10 | AKT3 | 2.62731349 |
| 11 | DAPK1 | 2.59424896 |
| 12 | PLK2 | 2.57011248 |
| 13 | PRPF4B | 2.35855141 |
| 14 | MAP3K9 | 2.03988606 |
| 15 | LATS2 | 2.02790499 |
| 16 | OXSR1 | 1.91428958 |
| 17 | MINK1 | 1.76736174 |
| 18 | SIK3 | 1.64264387 |
| 19 | MAP2K4 | 1.62021408 |
| 20 | TSSK6 | 1.44490717 |
| 21 | RIPK4 | 1.36681696 |
| 22 | MARK1 | 1.29790088 |
| 23 | SGK2 | 1.29304778 |
| 24 | GRK5 | 1.28916128 |
| 25 | BMPR2 | 1.24357393 |
| 26 | KSR1 | 1.17582468 |
| 27 | MAPK13 | 1.15755599 |
| 28 | PRKCG | 1.15654285 |
| 29 | BRSK1 | 1.14516741 |
| 30 | SCYL2 | 1.13965282 |
| 31 | PAK6 | 1.13828649 |
| 32 | NTRK2 | 1.12943854 |
| 33 | CAMKK2 | 1.11220003 |
| 34 | SGK223 | 1.09526119 |
| 35 | SGK494 | 1.09526119 |
| 36 | PTK2B | 1.07798988 |
| 37 | CDK5 | 1.07252871 |
| 38 | IRAK2 | 1.05239241 |
| 39 | CAMKK1 | 1.04845042 |
| 40 | PDK4 | 1.01999403 |
| 41 | PDK3 | 1.01999403 |
| 42 | ARAF | 0.99930697 |
| 43 | CAMK2A | 0.98554033 |
| 44 | TNIK | 0.97426147 |
| 45 | ALK | 0.97121236 |
| 46 | TESK1 | 0.94330686 |
| 47 | BRAF | 0.92944196 |
| 48 | LIMK1 | 0.90234606 |
| 49 | CAMK2B | 0.85073849 |
| 50 | DAPK3 | 0.82678302 |
| 51 | NME1 | 0.82528313 |
| 52 | PBK | 0.81247456 |
| 53 | MYLK | 0.77117183 |
| 54 | SGK3 | 0.75831624 |
| 55 | MAPK7 | 0.73249411 |
| 56 | MST1R | 0.72273478 |
| 57 | CDC7 | 0.72104280 |
| 58 | CDK18 | 0.71611667 |
| 59 | KSR2 | 0.70261038 |
| 60 | MAPK10 | 0.70040851 |
| 61 | PDK2 | 0.69710984 |
| 62 | MAPK15 | 0.68761564 |
| 63 | PRKCE | 0.68575081 |
| 64 | NTRK1 | 0.67299368 |
| 65 | NEK1 | 0.66508482 |
| 66 | WNK3 | 0.65332429 |
| 67 | CAMK1D | 0.64623052 |
| 68 | BCR | 0.64146825 |
| 69 | CSNK1G2 | 0.62674713 |
| 70 | CDK15 | 0.61875934 |
| 71 | PAK3 | 0.61475974 |
| 72 | CAMK1 | 0.61188830 |
| 73 | SGK1 | 0.60363827 |
| 74 | CDK14 | 0.59156734 |
| 75 | MARK2 | 0.59118846 |
| 76 | SMG1 | 0.57205385 |
| 77 | DYRK1A | 0.56481621 |
| 78 | FES | 0.56475223 |
| 79 | CAMK1G | 0.55664295 |
| 80 | MKNK2 | 0.55647044 |
| 81 | CDK3 | 0.55143074 |
| 82 | PRKD3 | 0.54607051 |
| 83 | PKN1 | 0.52034567 |
| 84 | STK38 | 0.50725351 |
| 85 | FER | 0.50672249 |
| 86 | CDK11A | 0.50399420 |
| 87 | TNK2 | 0.49833248 |
| 88 | MAPK12 | 0.49190777 |
| 89 | ADRBK2 | 0.48887260 |
| 90 | PINK1 | 0.48820399 |
| 91 | EEF2K | 0.48422301 |
| 92 | STK11 | 0.47653568 |
| 93 | MET | 0.47496738 |
| 94 | RAF1 | 0.46942043 |
| 95 | PRKCI | 0.45313928 |
| 96 | MUSK | 0.44863223 |
| 97 | SIK2 | 0.44048343 |
| 98 | CDK8 | 0.44042522 |
| 99 | PDK1 | 0.43152152 |
| 100 | MAPKAPK5 | 0.43089219 |
| 101 | ADRBK1 | 0.42467693 |
| 102 | PRKCZ | 0.42429101 |
| 103 | CAMK4 | 0.42397309 |
| 104 | UHMK1 | 0.41168363 |
| 105 | GRK7 | 0.40776893 |
| 106 | CAMK2D | 0.40182266 |
| 107 | NEK6 | 0.39986343 |
| 108 | AURKA | 0.38813337 |
| 109 | MAP3K2 | 0.38232379 |
| 110 | STK24 | 0.37010753 |
| 111 | PDPK1 | 0.36017239 |
| 112 | ROCK2 | 0.35985336 |
| 113 | CSNK1E | 0.35925600 |
| 114 | PRKCH | 0.34873413 |
| 115 | FGR | 0.34185429 |
| 116 | STK39 | 0.34075778 |
| 117 | CSNK1A1L | 0.32858855 |
| 118 | WEE1 | 0.31587670 |
| 119 | MAP2K1 | 0.30782727 |
| 120 | CAMK2G | 0.30345211 |
| 121 | MAP3K13 | 0.29478024 |
| 122 | PRKACA | 0.29187627 |
| 123 | ERBB3 | 0.27303629 |
| 124 | RPS6KA3 | 0.26464833 |
| 125 | PNCK | 0.26359340 |
| 126 | PLK3 | 0.26290224 |
| 127 | PHKG2 | 0.25153696 |
| 128 | PHKG1 | 0.25153696 |
| 129 | PRKCA | 0.25111419 |
| 130 | STK38L | 0.24484006 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.30693478 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 4.29917232 |
| 3 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.30268161 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.98911909 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.84061853 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.70498025 |
| 7 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.63167170 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.61314581 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.55052194 |
| 10 | GABAergic synapse_Homo sapiens_hsa04727 | 2.46432810 |
| 11 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.34322639 |
| 12 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.07422684 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.05585200 |
| 14 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 2.03954917 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 2.03479829 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.97804298 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.96644823 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.72107971 |
| 19 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.70669619 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.66520737 |
| 21 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.66201996 |
| 22 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.65664710 |
| 23 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.62874653 |
| 24 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.57619038 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53507458 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.52590906 |
| 27 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.50663600 |
| 28 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.50526271 |
| 29 | Long-term depression_Homo sapiens_hsa04730 | 1.45744418 |
| 30 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.43571495 |
| 31 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.37241701 |
| 32 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.35600367 |
| 33 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.23708902 |
| 34 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.20821088 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.18355447 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.15545915 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.14951007 |
| 38 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.11641261 |
| 39 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.09985983 |
| 40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.08717942 |
| 41 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.07198414 |
| 42 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.04377967 |
| 43 | Gap junction_Homo sapiens_hsa04540 | 1.03917549 |
| 44 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.02889556 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.98916578 |
| 46 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.97458375 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 0.96547804 |
| 48 | Axon guidance_Homo sapiens_hsa04360 | 0.93777380 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.86487623 |
| 50 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.86215969 |
| 51 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.82923889 |
| 52 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.81400891 |
| 53 | Melanogenesis_Homo sapiens_hsa04916 | 0.81398435 |
| 54 | Parkinsons disease_Homo sapiens_hsa05012 | 0.80544552 |
| 55 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.76757761 |
| 56 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.75778136 |
| 57 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.74872188 |
| 58 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.73556084 |
| 59 | Circadian rhythm_Homo sapiens_hsa04710 | 0.73113577 |
| 60 | Bile secretion_Homo sapiens_hsa04976 | 0.70991746 |
| 61 | Glioma_Homo sapiens_hsa05214 | 0.70426528 |
| 62 | Huntingtons disease_Homo sapiens_hsa05016 | 0.69597587 |
| 63 | Phagosome_Homo sapiens_hsa04145 | 0.67523211 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.67472916 |
| 65 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.65630209 |
| 66 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.64444483 |
| 67 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.64310400 |
| 68 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.63960098 |
| 69 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.60870307 |
| 70 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.59453324 |
| 71 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.58356373 |
| 72 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.55265169 |
| 73 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54993659 |
| 74 | Prion diseases_Homo sapiens_hsa05020 | 0.54082484 |
| 75 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53465963 |
| 76 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.53411752 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.53297388 |
| 78 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.52874727 |
| 79 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50335936 |
| 80 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.46948293 |
| 81 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.46286317 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.44951940 |
| 83 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.44593031 |
| 84 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.44539903 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.44106446 |
| 86 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.43172479 |
| 87 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.41672839 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41348115 |
| 89 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.39160433 |
| 90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.37515019 |
| 91 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.37500447 |
| 92 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.35157077 |
| 93 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.33424092 |
| 94 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31996710 |
| 95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.28527759 |
| 96 | Melanoma_Homo sapiens_hsa05218 | 0.28498139 |
| 97 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.28432440 |
| 98 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28356950 |
| 99 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.28254187 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27771169 |
| 101 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.26917006 |
| 102 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.25997666 |
| 103 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.25270124 |
| 104 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.24026919 |
| 105 | Carbon metabolism_Homo sapiens_hsa01200 | 0.23502081 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.23412304 |
| 107 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.22321088 |
| 108 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.21718513 |
| 109 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.21016514 |
| 110 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.20961706 |
| 111 | Tight junction_Homo sapiens_hsa04530 | 0.20278006 |
| 112 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.20022493 |
| 113 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.18319376 |
| 114 | Histidine metabolism_Homo sapiens_hsa00340 | 0.18250617 |
| 115 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.17366626 |
| 116 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.16959739 |
| 117 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.16680432 |
| 118 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.16474300 |
| 119 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.15995742 |
| 120 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.14766181 |
| 121 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.14409459 |
| 122 | Endocytosis_Homo sapiens_hsa04144 | 0.14136721 |
| 123 | Endometrial cancer_Homo sapiens_hsa05213 | 0.13185465 |

