ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	6.38040134
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.24792267
3	cilium movement (GO:0003341)	5.85413499
4	epithelial cilium movement (GO:0003351)	5.66104933
5	cilium or flagellum-dependent cell motility (GO:0001539)	5.40132569
6	desmosome organization (GO:0002934)	5.17498933
7	motile cilium assembly (GO:0044458)	4.86023506
8	intestinal epithelial cell development (GO:0060576)	4.47599345
9	axoneme assembly (GO:0035082)	4.37130012
10	keratinocyte development (GO:0003334)	4.29953846
11	cardiac right ventricle morphogenesis (GO:0003215)	4.01870254
12	behavioral response to nicotine (GO:0035095)	3.95481160
13	regulation of hippo signaling (GO:0035330)	3.70187816
14	regulation of water loss via skin (GO:0033561)	3.69143213
15	cornea development in camera-type eye (GO:0061303)	3.65479510
16	epithelial cell maturation (GO:0002070)	3.60619975
17	establishment of skin barrier (GO:0061436)	3.56520926
18	ear development (GO:0043583)	3.54707695
19	regulation of cell proliferation involved in kidney development (GO:1901722)	3.51077298
20	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.41495635
21	fucose catabolic process (GO:0019317)	3.32833407
22	L-fucose metabolic process (GO:0042354)	3.32833407
23	L-fucose catabolic process (GO:0042355)	3.32833407
24	regulation of cilium movement (GO:0003352)	3.26287737
25	prostate gland growth (GO:0060736)	3.12764955
26	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.10593023
27	hepatocyte apoptotic process (GO:0097284)	3.10097576
28	cilium organization (GO:0044782)	3.09874834
29	norepinephrine metabolic process (GO:0042415)	3.09648303
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.05051373
31	cilium assembly (GO:0042384)	2.99824792
32	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.97435564
33	establishment of monopolar cell polarity (GO:0061162)	2.97435564
34	negative regulation of T cell differentiation in thymus (GO:0033085)	2.95649299
35	ectoderm development (GO:0007398)	2.92657984
36	biotin metabolic process (GO:0006768)	2.91828113
37	positive regulation of keratinocyte differentiation (GO:0045618)	2.89906434
38	establishment of apical/basal cell polarity (GO:0035089)	2.89769370
39	negative regulation of kidney development (GO:0090185)	2.88733589
40	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.87705495
41	kynurenine metabolic process (GO:0070189)	2.87500005
42	cellular ketone body metabolic process (GO:0046950)	2.85293168
43	multicellular organismal water homeostasis (GO:0050891)	2.83798534
44	cilium morphogenesis (GO:0060271)	2.82153231
45	regulation of establishment of cell polarity (GO:2000114)	2.80483130
46	protein localization to cilium (GO:0061512)	2.79883330
47	multicellular organism reproduction (GO:0032504)	2.79743051
48	mammary gland epithelial cell differentiation (GO:0060644)	2.79613875
49	establishment of planar polarity (GO:0001736)	2.78979188
50	establishment of tissue polarity (GO:0007164)	2.78979188
51	piRNA metabolic process (GO:0034587)	2.78137486
52	vitamin transmembrane transport (GO:0035461)	2.75921541
53	mannosylation (GO:0097502)	2.75665655
54	auditory receptor cell stereocilium organization (GO:0060088)	2.73734339
55	primary alcohol catabolic process (GO:0034310)	2.72981019
56	limb bud formation (GO:0060174)	2.70564172
57	intraciliary transport (GO:0042073)	2.66352716
58	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.65284247
59	lung lobe morphogenesis (GO:0060463)	2.65118558
60	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.64619501
61	mesonephros development (GO:0001823)	2.63069398
62	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.63052643
63	positive regulation of epidermal cell differentiation (GO:0045606)	2.60285998
64	water homeostasis (GO:0030104)	2.58578446
65	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.58362438
66	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.58362438
67	DNA methylation involved in gamete generation (GO:0043046)	2.58152127
68	striated muscle atrophy (GO:0014891)	2.55659383
69	tryptophan catabolic process (GO:0006569)	2.55348402
70	indole-containing compound catabolic process (GO:0042436)	2.55348402
71	indolalkylamine catabolic process (GO:0046218)	2.55348402
72	lung epithelium development (GO:0060428)	2.53811988
73	ketone body metabolic process (GO:1902224)	2.53023753
74	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52691024
75	diterpenoid biosynthetic process (GO:0016102)	2.52582105
76	lateral sprouting from an epithelium (GO:0060601)	2.52524046
77	sympathetic nervous system development (GO:0048485)	2.52466163
78	left/right axis specification (GO:0070986)	2.51065717
79	peristalsis (GO:0030432)	2.50841319
80	regulation of autophagic vacuole assembly (GO:2000785)	2.50641310
81	response to food (GO:0032094)	2.49224343
82	protein import into peroxisome matrix (GO:0016558)	2.48695428
83	retinoic acid metabolic process (GO:0042573)	2.47724005
84	glandular epithelial cell differentiation (GO:0002067)	2.43622865
85	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.43497840
86	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.43082134
87	nucleotide transmembrane transport (GO:1901679)	2.39669373
88	ventricular system development (GO:0021591)	2.38228971
89	neuronal action potential (GO:0019228)	2.37936912
90	auditory receptor cell differentiation (GO:0042491)	2.35618804
91	nonmotile primary cilium assembly (GO:0035058)	2.35151319
92	embryonic epithelial tube formation (GO:0001838)	2.34538408
93	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.34497085
94	terpenoid biosynthetic process (GO:0016114)	2.34346281
95	nitric oxide biosynthetic process (GO:0006809)	2.33408435
96	polarized epithelial cell differentiation (GO:0030859)	2.33306544
97	regulation of keratinocyte differentiation (GO:0045616)	2.33277090
98	dorsal/ventral neural tube patterning (GO:0021904)	2.31114773
99	negative regulation of keratinocyte proliferation (GO:0010839)	2.30519149
100	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.27833754

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	5.57111412
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	4.88161289
3	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.60244281
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.48654307
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91518106
6	AHR_22903824_ChIP-Seq_MCF-7_Human	2.89279556
7	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.85999532
8	VDR_22108803_ChIP-Seq_LS180_Human	2.85145370
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.82609043
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.76752870
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.59344870
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.46716018
13	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.35035052
14	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.32089145
15	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.20613714
16	GATA3_24758297_ChIP-Seq_MCF-7_Human	2.07506090
17	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.88315452
18	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.87876200
19	HOXB7_26014856_ChIP-Seq_BT474_Human	1.85415094
20	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.84642964
21	ELF5_23300383_ChIP-Seq_T47D_Human	1.82122747
22	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.81668205
23	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.75739311
24	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.70775617
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.63572497
26	ERA_21632823_ChIP-Seq_H3396_Human	1.61895341
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61068683
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60634545
29	KDM5A_27292631_Chip-Seq_BREAST_Human	1.60602087
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55733598
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52250639
32	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.51321604
33	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.50746078
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46634914
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41201956
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41121396
37	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.33796206
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33023846
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33023846
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31654427
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31475678
42	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29571794
43	KLF5_25053715_ChIP-Seq_YYC3_Human	1.26687227
44	GATA4_25053715_ChIP-Seq_YYC3_Human	1.25803056
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25072297
46	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.24555210
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.22001809
48	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.20528136
49	RACK7_27058665_Chip-Seq_MCF-7_Human	1.20280516
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19314502
51	AR_20517297_ChIP-Seq_VCAP_Human	1.18754866
52	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18241194
53	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.16307198
54	GATA6_25053715_ChIP-Seq_YYC3_Human	1.13338215
55	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12361598
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.11210893
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.10850593
58	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08203766
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06797522
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06625341
61	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.06244792
62	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.05852910
63	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05544418
64	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05275764
65	EWS_26573619_Chip-Seq_HEK293_Human	1.02548817
66	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.99668711
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98699065
68	RAC3_21632823_ChIP-Seq_H3396_Human	0.96862352
69	GBX2_23144817_ChIP-Seq_PC3_Human	0.94598454
70	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.94408549
71	AR_25329375_ChIP-Seq_VCAP_Human	0.93558516
72	E2F1_20622854_ChIP-Seq_HELA_Human	0.92886004
73	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.92791371
74	SOX2_20726797_ChIP-Seq_SW620_Human	0.92604407
75	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91652913
76	AR_21572438_ChIP-Seq_LNCaP_Human	0.91560517
77	TP63_22573176_ChIP-Seq_HFKS_Human	0.91388760
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90016757
79	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88179002
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87434947
81	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.87097825
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.86380180
83	NCOR_22424771_ChIP-Seq_293T_Human	0.86340503
84	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.85858803
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.84208113
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.84182433
87	SMC4_20622854_ChIP-Seq_HELA_Human	0.83195346
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.81700728
89	P68_20966046_ChIP-Seq_HELA_Human	0.81179314
90	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.80569032
91	CTCF_20526341_ChIP-Seq_ESCs_Human	0.79984085
92	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.79777394
93	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.79672979
94	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.79547021
95	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.79352517
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.77519894
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.76979922
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.76605437
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.76240333
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.75552706

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000383_abnormal_hair_follicle	4.01353688
2	MP0010234_abnormal_vibrissa_follicle	3.57446314
3	MP0010678_abnormal_skin_adnexa	3.47642343
4	MP0000427_abnormal_hair_cycle	3.34154179
5	MP0002098_abnormal_vibrissa_morphology	2.94836336
6	MP0002653_abnormal_ependyma_morphology	2.89451461
7	MP0000566_synostosis	2.83952395
8	MP0008875_abnormal_xenobiotic_pharmacok	2.74546626
9	MP0004264_abnormal_extraembryonic_tissu	2.72055626
10	MP0002796_impaired_skin_barrier	2.69754952
11	MP0009780_abnormal_chondrocyte_physiolo	2.62505562
12	MP0000579_abnormal_nail_morphology	2.47182673
13	MP0005646_abnormal_pituitary_gland	2.02514180
14	MP0004043_abnormal_pH_regulation	1.95266621
15	MP0005083_abnormal_biliary_tract	1.94842645
16	MP0004381_abnormal_hair_follicle	1.85534528
17	MP0004885_abnormal_endolymph	1.80307622
18	MP0005501_abnormal_skin_physiology	1.71819253
19	MP0002876_abnormal_thyroid_physiology	1.70518684
20	MP0005377_hearing/vestibular/ear_phenot	1.69914969
21	MP0003878_abnormal_ear_physiology	1.69914969
22	MP0002160_abnormal_reproductive_system	1.65424963
23	MP0000467_abnormal_esophagus_morphology	1.63824473
24	MP0001968_abnormal_touch/_nociception	1.62367373
25	MP0000647_abnormal_sebaceous_gland	1.61236714
26	MP0004133_heterotaxia	1.57851481
27	MP0000377_abnormal_hair_follicle	1.55919678
28	MP0005551_abnormal_eye_electrophysiolog	1.55828453
29	MP0003011_delayed_dark_adaptation	1.53410357
30	MP0008872_abnormal_physiological_respon	1.52357325
31	MP0001346_abnormal_lacrimal_gland	1.51828346
32	MP0001919_abnormal_reproductive_system	1.48877147
33	MP0004782_abnormal_surfactant_physiolog	1.48693262
34	MP0002736_abnormal_nociception_after	1.44220027
35	MP0001873_stomach_inflammation	1.43818267
36	MP0002909_abnormal_adrenal_gland	1.36562448
37	MP0002282_abnormal_trachea_morphology	1.34941941
38	MP0003936_abnormal_reproductive_system	1.29803860
39	MP0003136_yellow_coat_color	1.29743994
40	MP0000627_abnormal_mammary_gland	1.29551466
41	MP0005389_reproductive_system_phenotype	1.27080535
42	MP0002254_reproductive_system_inflammat	1.22586721
43	MP0003787_abnormal_imprinting	1.22473884
44	MP0000538_abnormal_urinary_bladder	1.20147202
45	MP0010771_integument_phenotype	1.19450923
46	MP0005248_abnormal_Harderian_gland	1.19287623
47	MP0000537_abnormal_urethra_morphology	1.16532149
48	MP0001664_abnormal_digestion	1.15719331
49	MP0002102_abnormal_ear_morphology	1.13374261
50	MP0001485_abnormal_pinna_reflex	1.13322621
51	MP0005075_abnormal_melanosome_morpholog	1.13186027
52	MP0000470_abnormal_stomach_morphology	1.12112314
53	MP0002249_abnormal_larynx_morphology	1.10404492
54	MP0008789_abnormal_olfactory_epithelium	1.10387382
55	MP0002277_abnormal_respiratory_mucosa	1.07603955
56	MP0001881_abnormal_mammary_gland	1.07185067
57	MP0001216_abnormal_epidermal_layer	1.06872490
58	MP0002234_abnormal_pharynx_morphology	1.03971098
59	MP0001765_abnormal_ion_homeostasis	1.02706105
60	MP0000631_abnormal_neuroendocrine_gland	1.02495455
61	MP0000613_abnormal_salivary_gland	1.01499363
62	MP0003638_abnormal_response/metabolism_	1.01456996
63	MP0008877_abnormal_DNA_methylation	1.00585052
64	MP0000516_abnormal_urinary_system	1.00045791
65	MP0005367_renal/urinary_system_phenotyp	1.00045791
66	MP0002751_abnormal_autonomic_nervous	0.99494255
67	MP0010030_abnormal_orbit_morphology	0.99100918
68	MP0009384_cardiac_valve_regurgitation	0.98594700
69	MP0003315_abnormal_perineum_morphology	0.95804887
70	MP0000026_abnormal_inner_ear	0.94283970
71	MP0005408_hypopigmentation	0.92393625
72	MP0003718_maternal_effect	0.91864539
73	MP0003938_abnormal_ear_development	0.91818167
74	MP0003942_abnormal_urinary_system	0.90068947
75	MP0004742_abnormal_vestibular_system	0.88936444
76	MP0003880_abnormal_central_pattern	0.88320513
77	MP0001944_abnormal_pancreas_morphology	0.86608811
78	MP0005645_abnormal_hypothalamus_physiol	0.86443031
79	MP0001984_abnormal_olfaction	0.84394233
80	MP0003195_calcinosis	0.84227613
81	MP0003937_abnormal_limbs/digits/tail_de	0.83888431
82	MP0002928_abnormal_bile_duct	0.82701853
83	MP0000462_abnormal_digestive_system	0.81804873
84	MP0005253_abnormal_eye_physiology	0.79650570
85	MP0006072_abnormal_retinal_apoptosis	0.78709075
86	MP0002184_abnormal_innervation	0.78315416
87	MP0001502_abnormal_circadian_rhythm	0.77214021
88	MP0005174_abnormal_tail_pigmentation	0.75415745
89	MP0004019_abnormal_vitamin_homeostasis	0.75296609
90	MP0000367_abnormal_coat/_hair	0.74700504
91	MP0005499_abnormal_olfactory_system	0.73284860
92	MP0005394_taste/olfaction_phenotype	0.73284860
93	MP0003698_abnormal_male_reproductive	0.73004197
94	MP0008961_abnormal_basal_metabolism	0.72809513
95	MP0004147_increased_porphyrin_level	0.68944389
96	MP0000762_abnormal_tongue_morphology	0.67491263
97	MP0002210_abnormal_sex_determination	0.67110338
98	MP0002557_abnormal_social/conspecific_i	0.66743631
99	MP0005410_abnormal_fertilization	0.66470216
100	MP0008995_early_reproductive_senescence	0.66265428

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.34881244
2	Absent/shortened dynein arms (HP:0200106)	5.34881244
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.96360829
4	Abnormal respiratory motile cilium morphology (HP:0005938)	4.96360829
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.78244927
6	Abnormal ciliary motility (HP:0012262)	4.68116881
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.57175705
8	Concave nail (HP:0001598)	4.35875012
9	Pancreatic cysts (HP:0001737)	4.09941547
10	Rhinitis (HP:0012384)	3.84733784
11	True hermaphroditism (HP:0010459)	3.69893334
12	Pancreatic fibrosis (HP:0100732)	3.69493581
13	Molar tooth sign on MRI (HP:0002419)	3.49848938
14	Abnormality of midbrain morphology (HP:0002418)	3.49848938
15	Type II lissencephaly (HP:0007260)	3.46125879
16	Tubular atrophy (HP:0000092)	3.40296527
17	Chronic bronchitis (HP:0004469)	3.37511786
18	Cystic liver disease (HP:0006706)	3.26473900
19	Amelogenesis imperfecta (HP:0000705)	3.18949434
20	Nephronophthisis (HP:0000090)	3.17330199
21	Abnormality of the renal cortex (HP:0011035)	3.16591911
22	Abnormality of the renal medulla (HP:0100957)	3.04191705
23	Furrowed tongue (HP:0000221)	2.86437023
24	Bronchiectasis (HP:0002110)	2.77346486
25	Congenital stationary night blindness (HP:0007642)	2.68757538
26	Septate vagina (HP:0001153)	2.62290578
27	Pili torti (HP:0003777)	2.51114594
28	Hyperventilation (HP:0002883)	2.39518913
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36364102
30	Sclerocornea (HP:0000647)	2.30935655
31	Medial flaring of the eyebrow (HP:0010747)	2.27943109
32	Occipital encephalocele (HP:0002085)	2.23425478
33	Cerebellar dysplasia (HP:0007033)	2.20347662
34	Chronic hepatic failure (HP:0100626)	2.19473337
35	Tubulointerstitial nephritis (HP:0001970)	2.15201093
36	Lip pit (HP:0100267)	2.11297957
37	Curly hair (HP:0002212)	2.10943913
38	Right ventricular cardiomyopathy (HP:0011663)	2.10873868
39	Abnormal hair laboratory examination (HP:0003328)	2.09947586
40	Renal dysplasia (HP:0000110)	2.09926908
41	Woolly hair (HP:0002224)	2.07679115
42	Male pseudohermaphroditism (HP:0000037)	2.06114817
43	Pendular nystagmus (HP:0012043)	2.05130159
44	Congenital hepatic fibrosis (HP:0002612)	2.05024449
45	Large for gestational age (HP:0001520)	2.04911468
46	Abnormal drinking behavior (HP:0030082)	1.97785952
47	Polydipsia (HP:0001959)	1.97785952
48	Abnormal biliary tract physiology (HP:0012439)	1.96172153
49	Bile duct proliferation (HP:0001408)	1.96172153
50	Decreased circulating renin level (HP:0003351)	1.94635092
51	Hyperglycinuria (HP:0003108)	1.94583838
52	Infertility (HP:0000789)	1.92722489
53	Clumsiness (HP:0002312)	1.92357032
54	Breast carcinoma (HP:0003002)	1.91943931
55	Attenuation of retinal blood vessels (HP:0007843)	1.91881890
56	Anencephaly (HP:0002323)	1.89237829
57	Postaxial foot polydactyly (HP:0001830)	1.88682956
58	Gait imbalance (HP:0002141)	1.88342341
59	Severe muscular hypotonia (HP:0006829)	1.88302281
60	Congenital primary aphakia (HP:0007707)	1.87277619
61	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86040991
62	Patellar aplasia (HP:0006443)	1.84058318
63	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83571389
64	Aplasia/Hypoplasia of the patella (HP:0006498)	1.82975388
65	Hypotrichosis (HP:0001006)	1.80735184
66	Hypoplastic labia majora (HP:0000059)	1.80615719
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.80403456
68	Congenital, generalized hypertrichosis (HP:0004540)	1.76535536
69	Lissencephaly (HP:0001339)	1.76467822
70	Abnormality of nail color (HP:0100643)	1.75038986
71	Tubulointerstitial fibrosis (HP:0005576)	1.74824786
72	Increased corneal curvature (HP:0100692)	1.72705177
73	Keratoconus (HP:0000563)	1.72705177
74	Renal salt wasting (HP:0000127)	1.72522514
75	Retinal dysplasia (HP:0007973)	1.71547778
76	Nephrogenic diabetes insipidus (HP:0009806)	1.69352626
77	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.66645001
78	Flat capital femoral epiphysis (HP:0003370)	1.66026531
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.65755318
80	Decreased central vision (HP:0007663)	1.65290907
81	Ketoacidosis (HP:0001993)	1.64964644
82	Ketosis (HP:0001946)	1.64730816
83	Chronic sinusitis (HP:0011109)	1.64216516
84	Microretrognathia (HP:0000308)	1.63775060
85	Testicular atrophy (HP:0000029)	1.63747355
86	Hypoplasia of the pons (HP:0012110)	1.62756707
87	Abnormality of the pons (HP:0007361)	1.62581280
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.62394120
89	Preaxial hand polydactyly (HP:0001177)	1.61942712
90	Vaginal atresia (HP:0000148)	1.60521278
91	Alopecia of scalp (HP:0002293)	1.59964827
92	Abnormality of the labia majora (HP:0012881)	1.58847470
93	Genital tract atresia (HP:0001827)	1.58657837
94	Sparse lateral eyebrow (HP:0005338)	1.58641039
95	Nasal polyposis (HP:0100582)	1.54929701
96	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.54886946
97	Hamartoma of the eye (HP:0010568)	1.54340323
98	Tubulointerstitial abnormality (HP:0001969)	1.53192459
99	Hyperalaninemia (HP:0003348)	1.53031129
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.53031129

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.20866680
2	MAPKAPK3	4.05511861
3	FRK	3.95436500
4	MAPK15	3.78365110
5	MUSK	2.58044998
6	TRIB3	2.44709607
7	RPS6KB2	2.41086279
8	WNK4	2.30032902
9	TLK1	2.20650711
10	SIK1	2.16964600
11	GRK1	2.08283142
12	PKN2	2.01899628
13	STK39	1.98982349
14	PINK1	1.92136830
15	MST4	1.89785718
16	ADRBK2	1.88601089
17	NME1	1.86951626
18	ZAK	1.76670208
19	PIK3CA	1.75479970
20	PRKCI	1.75327765
21	MST1R	1.72172778
22	MAP2K2	1.71214766
23	FER	1.49576040
24	NUAK1	1.46514178
25	BMPR1B	1.43639869
26	VRK2	1.41753839
27	TSSK6	1.40991303
28	CASK	1.32847967
29	STK38L	1.28595185
30	MAP4K2	1.28117361
31	PNCK	1.19505617
32	CHUK	1.18347626
33	INSRR	1.12814588
34	BRSK2	1.12526217
35	WEE1	1.08073238
36	TAOK3	1.07455958
37	OXSR1	1.06330091
38	NEK6	1.04123730
39	LATS1	1.03784688
40	MET	0.99052986
41	WNK3	0.95737874
42	MAPK13	0.95337766
43	GRK6	0.89683807
44	PRKD3	0.87811062
45	MAPKAPK5	0.87773296
46	MAP2K1	0.83806381
47	TNK2	0.82987308
48	TAF1	0.80658586
49	FGFR2	0.79115384
50	MAP2K6	0.76049357
51	PAK3	0.71671466
52	PHKG2	0.69679714
53	PHKG1	0.69679714
54	EIF2AK1	0.66504516
55	ADRBK1	0.65862450
56	ERBB2	0.64690896
57	AKT3	0.64372240
58	TRIM28	0.59541767
59	EEF2K	0.58380925
60	PRKCE	0.57159993
61	IKBKB	0.56244238
62	SCYL2	0.55630834
63	MAP2K7	0.55125591
64	ILK	0.50753828
65	ACVR1B	0.49242407
66	IRAK1	0.48781767
67	NEK2	0.47945594
68	TGFBR1	0.47931072
69	CDK7	0.46285279
70	CAMKK1	0.45141203
71	CDK8	0.44705557
72	CSNK1A1	0.44520588
73	PTK2B	0.43437316
74	PTK6	0.41467450
75	STK24	0.40191597
76	EIF2AK2	0.40163731
77	CAMK1D	0.39906368
78	CAMK2D	0.39573694
79	RPS6KB1	0.39567610
80	PRKCZ	0.39460240
81	PRKAA2	0.39113797
82	RPS6KA2	0.37315894
83	CAMK2G	0.35013052
84	BCKDK	0.34858396
85	CAMK2B	0.34762363
86	STK3	0.34310234
87	MAP3K2	0.33510316
88	CSNK1D	0.32083471
89	RPS6KA5	0.31747267
90	PRKCG	0.31029729
91	CSNK1A1L	0.30860070
92	RPS6KA6	0.29790400
93	TRPM7	0.29259406
94	CHEK2	0.29180735
95	CSNK1G3	0.29120637
96	SMG1	0.29014627
97	PRKAA1	0.28653072
98	DYRK2	0.28310934
99	HIPK2	0.26887060
100	DAPK2	0.26185576

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.93180185
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.83391984
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.78298282
4	Phototransduction_Homo sapiens_hsa04744	2.53918503
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.50266911
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.43990126
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.20338412
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02184206
9	Histidine metabolism_Homo sapiens_hsa00340	2.01339480
10	Chemical carcinogenesis_Homo sapiens_hsa05204	1.97016228
11	ABC transporters_Homo sapiens_hsa02010	1.96564887
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90675292
13	Caffeine metabolism_Homo sapiens_hsa00232	1.86834129
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.86553765
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.84907356
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.78366242
17	Butanoate metabolism_Homo sapiens_hsa00650	1.67140806
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.66981648
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.63833274
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.63809200
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.62706720
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.60900223
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.58054935
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.53735045
25	Basal transcription factors_Homo sapiens_hsa03022	1.50587375
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47481577
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39879187
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38869757
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.37853011
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37777186
31	Sulfur relay system_Homo sapiens_hsa04122	1.36103214
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.34244096
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32918457
34	Peroxisome_Homo sapiens_hsa04146	1.31114441
35	Tyrosine metabolism_Homo sapiens_hsa00350	1.28812287
36	Taste transduction_Homo sapiens_hsa04742	1.28223105
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26689939
38	Sphingolipid metabolism_Homo sapiens_hsa00600	1.24551585
39	Homologous recombination_Homo sapiens_hsa03440	1.22799906
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.22308721
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.19844919
42	RNA polymerase_Homo sapiens_hsa03020	1.15023524
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06503710
44	Huntingtons disease_Homo sapiens_hsa05016	1.01584609
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97751305
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96169754
47	Retinol metabolism_Homo sapiens_hsa00830	0.93756342
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92952722
49	Glutathione metabolism_Homo sapiens_hsa00480	0.91460367
50	One carbon pool by folate_Homo sapiens_hsa00670	0.90650878
51	Protein export_Homo sapiens_hsa03060	0.88231218
52	Sulfur metabolism_Homo sapiens_hsa00920	0.86612197
53	Olfactory transduction_Homo sapiens_hsa04740	0.84492212
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81344392
55	Tight junction_Homo sapiens_hsa04530	0.79692316
56	Nicotine addiction_Homo sapiens_hsa05033	0.77545591
57	Propanoate metabolism_Homo sapiens_hsa00640	0.76905243
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.75961165
59	Metabolic pathways_Homo sapiens_hsa01100	0.74457541
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71381334
61	RNA degradation_Homo sapiens_hsa03018	0.70702664
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69996345
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69890457
64	Axon guidance_Homo sapiens_hsa04360	0.66508088
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.66122615
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64131952
67	Salivary secretion_Homo sapiens_hsa04970	0.63243164
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61940728
69	Regulation of autophagy_Homo sapiens_hsa04140	0.60740964
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59608349
71	Mineral absorption_Homo sapiens_hsa04978	0.58239628
72	Insulin secretion_Homo sapiens_hsa04911	0.58053283
73	Circadian rhythm_Homo sapiens_hsa04710	0.55317450
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54247031
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52614801
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.49383206
77	Serotonergic synapse_Homo sapiens_hsa04726	0.49343182
78	Parkinsons disease_Homo sapiens_hsa05012	0.48560238
79	Purine metabolism_Homo sapiens_hsa00230	0.48175454
80	Proteasome_Homo sapiens_hsa03050	0.48165738
81	p53 signaling pathway_Homo sapiens_hsa04115	0.48044872
82	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.46525345
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45325608
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44295368
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.41579639
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40849584
87	Circadian entrainment_Homo sapiens_hsa04713	0.40502932
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39548791
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.39516352
90	Alzheimers disease_Homo sapiens_hsa05010	0.39013790
91	Insulin resistance_Homo sapiens_hsa04931	0.37382184
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.36456862
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.35807300
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33221934
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32594717
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.32024482
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.31676266
98	Lysine degradation_Homo sapiens_hsa00310	0.30858072
99	Choline metabolism in cancer_Homo sapiens_hsa05231	0.29618885
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.27454768

FAM83H-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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