FAM83H-AS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.38040134
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.24792267
3cilium movement (GO:0003341)5.85413499
4epithelial cilium movement (GO:0003351)5.66104933
5cilium or flagellum-dependent cell motility (GO:0001539)5.40132569
6desmosome organization (GO:0002934)5.17498933
7motile cilium assembly (GO:0044458)4.86023506
8intestinal epithelial cell development (GO:0060576)4.47599345
9axoneme assembly (GO:0035082)4.37130012
10keratinocyte development (GO:0003334)4.29953846
11cardiac right ventricle morphogenesis (GO:0003215)4.01870254
12behavioral response to nicotine (GO:0035095)3.95481160
13regulation of hippo signaling (GO:0035330)3.70187816
14regulation of water loss via skin (GO:0033561)3.69143213
15cornea development in camera-type eye (GO:0061303)3.65479510
16epithelial cell maturation (GO:0002070)3.60619975
17establishment of skin barrier (GO:0061436)3.56520926
18ear development (GO:0043583)3.54707695
19regulation of cell proliferation involved in kidney development (GO:1901722)3.51077298
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41495635
21fucose catabolic process (GO:0019317)3.32833407
22L-fucose metabolic process (GO:0042354)3.32833407
23L-fucose catabolic process (GO:0042355)3.32833407
24regulation of cilium movement (GO:0003352)3.26287737
25prostate gland growth (GO:0060736)3.12764955
26regulation of establishment or maintenance of cell polarity (GO:0032878)3.10593023
27hepatocyte apoptotic process (GO:0097284)3.10097576
28cilium organization (GO:0044782)3.09874834
29norepinephrine metabolic process (GO:0042415)3.09648303
30preassembly of GPI anchor in ER membrane (GO:0016254)3.05051373
31cilium assembly (GO:0042384)2.99824792
32establishment of monopolar cell polarity (GO:0061162)2.97435564
33establishment or maintenance of monopolar cell polarity (GO:0061339)2.97435564
34negative regulation of T cell differentiation in thymus (GO:0033085)2.95649299
35ectoderm development (GO:0007398)2.92657984
36biotin metabolic process (GO:0006768)2.91828113
37positive regulation of keratinocyte differentiation (GO:0045618)2.89906434
38establishment of apical/basal cell polarity (GO:0035089)2.89769370
39negative regulation of kidney development (GO:0090185)2.88733589
40calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87705495
41kynurenine metabolic process (GO:0070189)2.87500005
42cellular ketone body metabolic process (GO:0046950)2.85293168
43multicellular organismal water homeostasis (GO:0050891)2.83798534
44cilium morphogenesis (GO:0060271)2.82153231
45regulation of establishment of cell polarity (GO:2000114)2.80483130
46protein localization to cilium (GO:0061512)2.79883330
47multicellular organism reproduction (GO:0032504)2.79743051
48mammary gland epithelial cell differentiation (GO:0060644)2.79613875
49establishment of tissue polarity (GO:0007164)2.78979188
50establishment of planar polarity (GO:0001736)2.78979188
51piRNA metabolic process (GO:0034587)2.78137486
52vitamin transmembrane transport (GO:0035461)2.75921541
53mannosylation (GO:0097502)2.75665655
54auditory receptor cell stereocilium organization (GO:0060088)2.73734339
55primary alcohol catabolic process (GO:0034310)2.72981019
56limb bud formation (GO:0060174)2.70564172
57intraciliary transport (GO:0042073)2.66352716
58phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65284247
59lung lobe morphogenesis (GO:0060463)2.65118558
60pyrimidine-containing compound transmembrane transport (GO:0072531)2.64619501
61mesonephros development (GO:0001823)2.63069398
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.63052643
63positive regulation of epidermal cell differentiation (GO:0045606)2.60285998
64water homeostasis (GO:0030104)2.58578446
653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58362438
66purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58362438
67DNA methylation involved in gamete generation (GO:0043046)2.58152127
68striated muscle atrophy (GO:0014891)2.55659383
69tryptophan catabolic process (GO:0006569)2.55348402
70indole-containing compound catabolic process (GO:0042436)2.55348402
71indolalkylamine catabolic process (GO:0046218)2.55348402
72lung epithelium development (GO:0060428)2.53811988
73ketone body metabolic process (GO:1902224)2.53023753
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52691024
75diterpenoid biosynthetic process (GO:0016102)2.52582105
76lateral sprouting from an epithelium (GO:0060601)2.52524046
77sympathetic nervous system development (GO:0048485)2.52466163
78left/right axis specification (GO:0070986)2.51065717
79peristalsis (GO:0030432)2.50841319
80regulation of autophagic vacuole assembly (GO:2000785)2.50641310
81response to food (GO:0032094)2.49224343
82protein import into peroxisome matrix (GO:0016558)2.48695428
83retinoic acid metabolic process (GO:0042573)2.47724005
84glandular epithelial cell differentiation (GO:0002067)2.43622865
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.43497840
86phosphatidylserine acyl-chain remodeling (GO:0036150)2.43082134
87nucleotide transmembrane transport (GO:1901679)2.39669373
88ventricular system development (GO:0021591)2.38228971
89neuronal action potential (GO:0019228)2.37936912
90auditory receptor cell differentiation (GO:0042491)2.35618804
91nonmotile primary cilium assembly (GO:0035058)2.35151319
92embryonic epithelial tube formation (GO:0001838)2.34538408
93positive regulation of fatty acid beta-oxidation (GO:0032000)2.34497085
94terpenoid biosynthetic process (GO:0016114)2.34346281
95nitric oxide biosynthetic process (GO:0006809)2.33408435
96polarized epithelial cell differentiation (GO:0030859)2.33306544
97regulation of keratinocyte differentiation (GO:0045616)2.33277090
98dorsal/ventral neural tube patterning (GO:0021904)2.31114773
99negative regulation of keratinocyte proliferation (GO:0010839)2.30519149
100phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.27833754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.57111412
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.88161289
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.60244281
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.48654307
5ZNF274_21170338_ChIP-Seq_K562_Hela2.91518106
6AHR_22903824_ChIP-Seq_MCF-7_Human2.89279556
7ESR1_15608294_ChIP-ChIP_MCF-7_Human2.85999532
8VDR_22108803_ChIP-Seq_LS180_Human2.85145370
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82609043
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76752870
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.59344870
12ER_23166858_ChIP-Seq_MCF-7_Human2.46716018
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.35035052
14ARNT_22903824_ChIP-Seq_MCF-7_Human2.32089145
15RUNX1_27514584_Chip-Seq_MCF-7_Human2.20613714
16GATA3_24758297_ChIP-Seq_MCF-7_Human2.07506090
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88315452
18TDRD3_21172665_ChIP-Seq_MCF-7_Human1.87876200
19HOXB7_26014856_ChIP-Seq_BT474_Human1.85415094
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84642964
21ELF5_23300383_ChIP-Seq_T47D_Human1.82122747
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81668205
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.75739311
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70775617
25ZNF263_19887448_ChIP-Seq_K562_Human1.63572497
26ERA_21632823_ChIP-Seq_H3396_Human1.61895341
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61068683
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60634545
29KDM5A_27292631_Chip-Seq_BREAST_Human1.60602087
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55733598
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.52250639
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51321604
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50746078
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46634914
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41201956
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41121396
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33796206
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33023846
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.33023846
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.31654427
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31475678
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29571794
43KLF5_25053715_ChIP-Seq_YYC3_Human1.26687227
44GATA4_25053715_ChIP-Seq_YYC3_Human1.25803056
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.25072297
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.24555210
47IGF1R_20145208_ChIP-Seq_DFB_Human1.22001809
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20528136
49RACK7_27058665_Chip-Seq_MCF-7_Human1.20280516
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19314502
51AR_20517297_ChIP-Seq_VCAP_Human1.18754866
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18241194
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.16307198
54GATA6_25053715_ChIP-Seq_YYC3_Human1.13338215
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.12361598
56BCAT_22108803_ChIP-Seq_LS180_Human1.11210893
57TP53_22573176_ChIP-Seq_HFKS_Human1.10850593
58P53_21459846_ChIP-Seq_SAOS-2_Human1.08203766
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06797522
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06625341
61PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06244792
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05852910
63DROSHA_22980978_ChIP-Seq_HELA_Human1.05544418
64OCT4_20526341_ChIP-Seq_ESCs_Human1.05275764
65EWS_26573619_Chip-Seq_HEK293_Human1.02548817
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99668711
67NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98699065
68RAC3_21632823_ChIP-Seq_H3396_Human0.96862352
69GBX2_23144817_ChIP-Seq_PC3_Human0.94598454
70GABP_17652178_ChIP-ChIP_JURKAT_Human0.94408549
71AR_25329375_ChIP-Seq_VCAP_Human0.93558516
72E2F1_20622854_ChIP-Seq_HELA_Human0.92886004
73FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92791371
74SOX2_20726797_ChIP-Seq_SW620_Human0.92604407
75IRF1_19129219_ChIP-ChIP_H3396_Human0.91652913
76AR_21572438_ChIP-Seq_LNCaP_Human0.91560517
77TP63_22573176_ChIP-Seq_HFKS_Human0.91388760
78NANOG_20526341_ChIP-Seq_ESCs_Human0.90016757
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88179002
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87434947
81ERG_21242973_ChIP-ChIP_JURKAT_Human0.87097825
82MYC_18940864_ChIP-ChIP_HL60_Human0.86380180
83NCOR_22424771_ChIP-Seq_293T_Human0.86340503
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85858803
85TCF4_22108803_ChIP-Seq_LS180_Human0.84208113
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.84182433
87SMC4_20622854_ChIP-Seq_HELA_Human0.83195346
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81700728
89P68_20966046_ChIP-Seq_HELA_Human0.81179314
90SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80569032
91CTCF_20526341_ChIP-Seq_ESCs_Human0.79984085
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.79777394
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79672979
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.79547021
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79352517
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77519894
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76979922
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76605437
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.76240333
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75552706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle4.01353688
2MP0010234_abnormal_vibrissa_follicle3.57446314
3MP0010678_abnormal_skin_adnexa3.47642343
4MP0000427_abnormal_hair_cycle3.34154179
5MP0002098_abnormal_vibrissa_morphology2.94836336
6MP0002653_abnormal_ependyma_morphology2.89451461
7MP0000566_synostosis2.83952395
8MP0008875_abnormal_xenobiotic_pharmacok2.74546626
9MP0004264_abnormal_extraembryonic_tissu2.72055626
10MP0002796_impaired_skin_barrier2.69754952
11MP0009780_abnormal_chondrocyte_physiolo2.62505562
12MP0000579_abnormal_nail_morphology2.47182673
13MP0005646_abnormal_pituitary_gland2.02514180
14MP0004043_abnormal_pH_regulation1.95266621
15MP0005083_abnormal_biliary_tract1.94842645
16MP0004381_abnormal_hair_follicle1.85534528
17MP0004885_abnormal_endolymph1.80307622
18MP0005501_abnormal_skin_physiology1.71819253
19MP0002876_abnormal_thyroid_physiology1.70518684
20MP0003878_abnormal_ear_physiology1.69914969
21MP0005377_hearing/vestibular/ear_phenot1.69914969
22MP0002160_abnormal_reproductive_system1.65424963
23MP0000467_abnormal_esophagus_morphology1.63824473
24MP0001968_abnormal_touch/_nociception1.62367373
25MP0000647_abnormal_sebaceous_gland1.61236714
26MP0004133_heterotaxia1.57851481
27MP0000377_abnormal_hair_follicle1.55919678
28MP0005551_abnormal_eye_electrophysiolog1.55828453
29MP0003011_delayed_dark_adaptation1.53410357
30MP0008872_abnormal_physiological_respon1.52357325
31MP0001346_abnormal_lacrimal_gland1.51828346
32MP0001919_abnormal_reproductive_system1.48877147
33MP0004782_abnormal_surfactant_physiolog1.48693262
34MP0002736_abnormal_nociception_after1.44220027
35MP0001873_stomach_inflammation1.43818267
36MP0002909_abnormal_adrenal_gland1.36562448
37MP0002282_abnormal_trachea_morphology1.34941941
38MP0003936_abnormal_reproductive_system1.29803860
39MP0003136_yellow_coat_color1.29743994
40MP0000627_abnormal_mammary_gland1.29551466
41MP0005389_reproductive_system_phenotype1.27080535
42MP0002254_reproductive_system_inflammat1.22586721
43MP0003787_abnormal_imprinting1.22473884
44MP0000538_abnormal_urinary_bladder1.20147202
45MP0010771_integument_phenotype1.19450923
46MP0005248_abnormal_Harderian_gland1.19287623
47MP0000537_abnormal_urethra_morphology1.16532149
48MP0001664_abnormal_digestion1.15719331
49MP0002102_abnormal_ear_morphology1.13374261
50MP0001485_abnormal_pinna_reflex1.13322621
51MP0005075_abnormal_melanosome_morpholog1.13186027
52MP0000470_abnormal_stomach_morphology1.12112314
53MP0002249_abnormal_larynx_morphology1.10404492
54MP0008789_abnormal_olfactory_epithelium1.10387382
55MP0002277_abnormal_respiratory_mucosa1.07603955
56MP0001881_abnormal_mammary_gland1.07185067
57MP0001216_abnormal_epidermal_layer1.06872490
58MP0002234_abnormal_pharynx_morphology1.03971098
59MP0001765_abnormal_ion_homeostasis1.02706105
60MP0000631_abnormal_neuroendocrine_gland1.02495455
61MP0000613_abnormal_salivary_gland1.01499363
62MP0003638_abnormal_response/metabolism_1.01456996
63MP0008877_abnormal_DNA_methylation1.00585052
64MP0005367_renal/urinary_system_phenotyp1.00045791
65MP0000516_abnormal_urinary_system1.00045791
66MP0002751_abnormal_autonomic_nervous0.99494255
67MP0010030_abnormal_orbit_morphology0.99100918
68MP0009384_cardiac_valve_regurgitation0.98594700
69MP0003315_abnormal_perineum_morphology0.95804887
70MP0000026_abnormal_inner_ear0.94283970
71MP0005408_hypopigmentation0.92393625
72MP0003718_maternal_effect0.91864539
73MP0003938_abnormal_ear_development0.91818167
74MP0003942_abnormal_urinary_system0.90068947
75MP0004742_abnormal_vestibular_system0.88936444
76MP0003880_abnormal_central_pattern0.88320513
77MP0001944_abnormal_pancreas_morphology0.86608811
78MP0005645_abnormal_hypothalamus_physiol0.86443031
79MP0001984_abnormal_olfaction0.84394233
80MP0003195_calcinosis0.84227613
81MP0003937_abnormal_limbs/digits/tail_de0.83888431
82MP0002928_abnormal_bile_duct0.82701853
83MP0000462_abnormal_digestive_system0.81804873
84MP0005253_abnormal_eye_physiology0.79650570
85MP0006072_abnormal_retinal_apoptosis0.78709075
86MP0002184_abnormal_innervation0.78315416
87MP0001502_abnormal_circadian_rhythm0.77214021
88MP0005174_abnormal_tail_pigmentation0.75415745
89MP0004019_abnormal_vitamin_homeostasis0.75296609
90MP0000367_abnormal_coat/_hair0.74700504
91MP0005394_taste/olfaction_phenotype0.73284860
92MP0005499_abnormal_olfactory_system0.73284860
93MP0003698_abnormal_male_reproductive0.73004197
94MP0008961_abnormal_basal_metabolism0.72809513
95MP0004147_increased_porphyrin_level0.68944389
96MP0000762_abnormal_tongue_morphology0.67491263
97MP0002210_abnormal_sex_determination0.67110338
98MP0002557_abnormal_social/conspecific_i0.66743631
99MP0005410_abnormal_fertilization0.66470216
100MP0008995_early_reproductive_senescence0.66265428

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.34881244
2Absent/shortened dynein arms (HP:0200106)5.34881244
3Abnormal respiratory motile cilium morphology (HP:0005938)4.96360829
4Abnormal respiratory epithelium morphology (HP:0012253)4.96360829
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.78244927
6Abnormal ciliary motility (HP:0012262)4.68116881
7Abnormal respiratory motile cilium physiology (HP:0012261)4.57175705
8Concave nail (HP:0001598)4.35875012
9Pancreatic cysts (HP:0001737)4.09941547
10Rhinitis (HP:0012384)3.84733784
11True hermaphroditism (HP:0010459)3.69893334
12Pancreatic fibrosis (HP:0100732)3.69493581
13Molar tooth sign on MRI (HP:0002419)3.49848938
14Abnormality of midbrain morphology (HP:0002418)3.49848938
15Type II lissencephaly (HP:0007260)3.46125879
16Tubular atrophy (HP:0000092)3.40296527
17Chronic bronchitis (HP:0004469)3.37511786
18Cystic liver disease (HP:0006706)3.26473900
19Amelogenesis imperfecta (HP:0000705)3.18949434
20Nephronophthisis (HP:0000090)3.17330199
21Abnormality of the renal cortex (HP:0011035)3.16591911
22Abnormality of the renal medulla (HP:0100957)3.04191705
23Furrowed tongue (HP:0000221)2.86437023
24Bronchiectasis (HP:0002110)2.77346486
25Congenital stationary night blindness (HP:0007642)2.68757538
26Septate vagina (HP:0001153)2.62290578
27Pili torti (HP:0003777)2.51114594
28Hyperventilation (HP:0002883)2.39518913
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.36364102
30Sclerocornea (HP:0000647)2.30935655
31Medial flaring of the eyebrow (HP:0010747)2.27943109
32Occipital encephalocele (HP:0002085)2.23425478
33Cerebellar dysplasia (HP:0007033)2.20347662
34Chronic hepatic failure (HP:0100626)2.19473337
35Tubulointerstitial nephritis (HP:0001970)2.15201093
36Lip pit (HP:0100267)2.11297957
37Curly hair (HP:0002212)2.10943913
38Right ventricular cardiomyopathy (HP:0011663)2.10873868
39Abnormal hair laboratory examination (HP:0003328)2.09947586
40Renal dysplasia (HP:0000110)2.09926908
41Woolly hair (HP:0002224)2.07679115
42Male pseudohermaphroditism (HP:0000037)2.06114817
43Pendular nystagmus (HP:0012043)2.05130159
44Congenital hepatic fibrosis (HP:0002612)2.05024449
45Large for gestational age (HP:0001520)2.04911468
46Abnormal drinking behavior (HP:0030082)1.97785952
47Polydipsia (HP:0001959)1.97785952
48Abnormal biliary tract physiology (HP:0012439)1.96172153
49Bile duct proliferation (HP:0001408)1.96172153
50Decreased circulating renin level (HP:0003351)1.94635092
51Hyperglycinuria (HP:0003108)1.94583838
52Infertility (HP:0000789)1.92722489
53Clumsiness (HP:0002312)1.92357032
54Breast carcinoma (HP:0003002)1.91943931
55Attenuation of retinal blood vessels (HP:0007843)1.91881890
56Anencephaly (HP:0002323)1.89237829
57Postaxial foot polydactyly (HP:0001830)1.88682956
58Gait imbalance (HP:0002141)1.88342341
59Severe muscular hypotonia (HP:0006829)1.88302281
60Congenital primary aphakia (HP:0007707)1.87277619
61Aplasia/hypoplasia of the uterus (HP:0008684)1.86040991
62Patellar aplasia (HP:0006443)1.84058318
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83571389
64Aplasia/Hypoplasia of the patella (HP:0006498)1.82975388
65Hypotrichosis (HP:0001006)1.80735184
66Hypoplastic labia majora (HP:0000059)1.80615719
67Abnormal rod and cone electroretinograms (HP:0008323)1.80403456
68Congenital, generalized hypertrichosis (HP:0004540)1.76535536
69Lissencephaly (HP:0001339)1.76467822
70Abnormality of nail color (HP:0100643)1.75038986
71Tubulointerstitial fibrosis (HP:0005576)1.74824786
72Increased corneal curvature (HP:0100692)1.72705177
73Keratoconus (HP:0000563)1.72705177
74Renal salt wasting (HP:0000127)1.72522514
75Retinal dysplasia (HP:0007973)1.71547778
76Nephrogenic diabetes insipidus (HP:0009806)1.69352626
77Abnormality of the proximal phalanges of the hand (HP:0009834)1.66645001
78Flat capital femoral epiphysis (HP:0003370)1.66026531
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.65755318
80Decreased central vision (HP:0007663)1.65290907
81Ketoacidosis (HP:0001993)1.64964644
82Ketosis (HP:0001946)1.64730816
83Chronic sinusitis (HP:0011109)1.64216516
84Microretrognathia (HP:0000308)1.63775060
85Testicular atrophy (HP:0000029)1.63747355
86Hypoplasia of the pons (HP:0012110)1.62756707
87Abnormality of the pons (HP:0007361)1.62581280
88Bony spicule pigmentary retinopathy (HP:0007737)1.62394120
89Preaxial hand polydactyly (HP:0001177)1.61942712
90Vaginal atresia (HP:0000148)1.60521278
91Alopecia of scalp (HP:0002293)1.59964827
92Abnormality of the labia majora (HP:0012881)1.58847470
93Genital tract atresia (HP:0001827)1.58657837
94Sparse lateral eyebrow (HP:0005338)1.58641039
95Nasal polyposis (HP:0100582)1.54929701
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54886946
97Hamartoma of the eye (HP:0010568)1.54340323
98Tubulointerstitial abnormality (HP:0001969)1.53192459
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53031129
100Hyperalaninemia (HP:0003348)1.53031129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.20866680
2MAPKAPK34.05511861
3FRK3.95436500
4MAPK153.78365110
5MUSK2.58044998
6TRIB32.44709607
7RPS6KB22.41086279
8WNK42.30032902
9TLK12.20650711
10SIK12.16964600
11GRK12.08283142
12PKN22.01899628
13STK391.98982349
14PINK11.92136830
15MST41.89785718
16ADRBK21.88601089
17NME11.86951626
18ZAK1.76670208
19PIK3CA1.75479970
20PRKCI1.75327765
21MST1R1.72172778
22MAP2K21.71214766
23FER1.49576040
24NUAK11.46514178
25BMPR1B1.43639869
26VRK21.41753839
27TSSK61.40991303
28CASK1.32847967
29STK38L1.28595185
30MAP4K21.28117361
31PNCK1.19505617
32CHUK1.18347626
33INSRR1.12814588
34BRSK21.12526217
35WEE11.08073238
36TAOK31.07455958
37OXSR11.06330091
38NEK61.04123730
39LATS11.03784688
40MET0.99052986
41WNK30.95737874
42MAPK130.95337766
43GRK60.89683807
44PRKD30.87811062
45MAPKAPK50.87773296
46MAP2K10.83806381
47TNK20.82987308
48TAF10.80658586
49FGFR20.79115384
50MAP2K60.76049357
51PAK30.71671466
52PHKG10.69679714
53PHKG20.69679714
54EIF2AK10.66504516
55ADRBK10.65862450
56ERBB20.64690896
57AKT30.64372240
58TRIM280.59541767
59EEF2K0.58380925
60PRKCE0.57159993
61IKBKB0.56244238
62SCYL20.55630834
63MAP2K70.55125591
64ILK0.50753828
65ACVR1B0.49242407
66IRAK10.48781767
67NEK20.47945594
68TGFBR10.47931072
69CDK70.46285279
70CAMKK10.45141203
71CDK80.44705557
72CSNK1A10.44520588
73PTK2B0.43437316
74PTK60.41467450
75STK240.40191597
76EIF2AK20.40163731
77CAMK1D0.39906368
78CAMK2D0.39573694
79RPS6KB10.39567610
80PRKCZ0.39460240
81PRKAA20.39113797
82RPS6KA20.37315894
83CAMK2G0.35013052
84BCKDK0.34858396
85CAMK2B0.34762363
86STK30.34310234
87MAP3K20.33510316
88CSNK1D0.32083471
89RPS6KA50.31747267
90PRKCG0.31029729
91CSNK1A1L0.30860070
92RPS6KA60.29790400
93TRPM70.29259406
94CHEK20.29180735
95CSNK1G30.29120637
96SMG10.29014627
97PRKAA10.28653072
98DYRK20.28310934
99HIPK20.26887060
100DAPK20.26185576

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93180185
2Linoleic acid metabolism_Homo sapiens_hsa005912.83391984
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.78298282
4Phototransduction_Homo sapiens_hsa047442.53918503
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50266911
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.43990126
7Nitrogen metabolism_Homo sapiens_hsa009102.20338412
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02184206
9Histidine metabolism_Homo sapiens_hsa003402.01339480
10Chemical carcinogenesis_Homo sapiens_hsa052041.97016228
11ABC transporters_Homo sapiens_hsa020101.96564887
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90675292
13Caffeine metabolism_Homo sapiens_hsa002321.86834129
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86553765
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84907356
16Selenocompound metabolism_Homo sapiens_hsa004501.78366242
17Butanoate metabolism_Homo sapiens_hsa006501.67140806
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.66981648
19Phenylalanine metabolism_Homo sapiens_hsa003601.63833274
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63809200
21beta-Alanine metabolism_Homo sapiens_hsa004101.62706720
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.60900223
23Tryptophan metabolism_Homo sapiens_hsa003801.58054935
24Ether lipid metabolism_Homo sapiens_hsa005651.53735045
25Basal transcription factors_Homo sapiens_hsa030221.50587375
26Fanconi anemia pathway_Homo sapiens_hsa034601.47481577
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39879187
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38869757
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37853011
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37777186
31Sulfur relay system_Homo sapiens_hsa041221.36103214
32Ovarian steroidogenesis_Homo sapiens_hsa049131.34244096
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.32918457
34Peroxisome_Homo sapiens_hsa041461.31114441
35Tyrosine metabolism_Homo sapiens_hsa003501.28812287
36Taste transduction_Homo sapiens_hsa047421.28223105
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26689939
38Sphingolipid metabolism_Homo sapiens_hsa006001.24551585
39Homologous recombination_Homo sapiens_hsa034401.22799906
40Steroid biosynthesis_Homo sapiens_hsa001001.22308721
41Oxidative phosphorylation_Homo sapiens_hsa001901.19844919
42RNA polymerase_Homo sapiens_hsa030201.15023524
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06503710
44Huntingtons disease_Homo sapiens_hsa050161.01584609
45Fatty acid biosynthesis_Homo sapiens_hsa000610.97751305
46Arachidonic acid metabolism_Homo sapiens_hsa005900.96169754
47Retinol metabolism_Homo sapiens_hsa008300.93756342
48Vitamin digestion and absorption_Homo sapiens_hsa049770.92952722
49Glutathione metabolism_Homo sapiens_hsa004800.91460367
50One carbon pool by folate_Homo sapiens_hsa006700.90650878
51Protein export_Homo sapiens_hsa030600.88231218
52Sulfur metabolism_Homo sapiens_hsa009200.86612197
53Olfactory transduction_Homo sapiens_hsa047400.84492212
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81344392
55Tight junction_Homo sapiens_hsa045300.79692316
56Nicotine addiction_Homo sapiens_hsa050330.77545591
57Propanoate metabolism_Homo sapiens_hsa006400.76905243
58Hippo signaling pathway_Homo sapiens_hsa043900.75961165
59Metabolic pathways_Homo sapiens_hsa011000.74457541
60Hedgehog signaling pathway_Homo sapiens_hsa043400.71381334
61RNA degradation_Homo sapiens_hsa030180.70702664
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.69996345
63Collecting duct acid secretion_Homo sapiens_hsa049660.69890457
64Axon guidance_Homo sapiens_hsa043600.66508088
65Basal cell carcinoma_Homo sapiens_hsa052170.66122615
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64131952
67Salivary secretion_Homo sapiens_hsa049700.63243164
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61940728
69Regulation of autophagy_Homo sapiens_hsa041400.60740964
70N-Glycan biosynthesis_Homo sapiens_hsa005100.59608349
71Mineral absorption_Homo sapiens_hsa049780.58239628
72Insulin secretion_Homo sapiens_hsa049110.58053283
73Circadian rhythm_Homo sapiens_hsa047100.55317450
74Arginine and proline metabolism_Homo sapiens_hsa003300.54247031
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.52614801
76Nucleotide excision repair_Homo sapiens_hsa034200.49383206
77Serotonergic synapse_Homo sapiens_hsa047260.49343182
78Parkinsons disease_Homo sapiens_hsa050120.48560238
79Purine metabolism_Homo sapiens_hsa002300.48175454
80Proteasome_Homo sapiens_hsa030500.48165738
81p53 signaling pathway_Homo sapiens_hsa041150.48044872
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46525345
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45325608
84Pyrimidine metabolism_Homo sapiens_hsa002400.44295368
85Glutamatergic synapse_Homo sapiens_hsa047240.41579639
86Glycerolipid metabolism_Homo sapiens_hsa005610.40849584
87Circadian entrainment_Homo sapiens_hsa047130.40502932
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.39548791
89AMPK signaling pathway_Homo sapiens_hsa041520.39516352
90Alzheimers disease_Homo sapiens_hsa050100.39013790
91Insulin resistance_Homo sapiens_hsa049310.37382184
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36456862
93Cardiac muscle contraction_Homo sapiens_hsa042600.35807300
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33221934
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32594717
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32024482
97Fatty acid metabolism_Homo sapiens_hsa012120.31676266
98Lysine degradation_Homo sapiens_hsa003100.30858072
99Choline metabolism in cancer_Homo sapiens_hsa052310.29618885
100Calcium signaling pathway_Homo sapiens_hsa040200.27454768

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